Node.js is a JavaScript runtime built on Chrome's V8 engine that allows building scalable network applications using JavaScript on the server-side. It uses an event-driven, non-blocking I/O model that makes it lightweight and efficient, suitable for data-intensive real-time applications that run across distributed devices. Common uses of Node.js include building web servers, file upload clients, ad servers, chat servers, and any real-time data applications. The document provides an introduction to Node.js concepts like callbacks, blocking vs non-blocking code, the event loop, streams, events, and modules.