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Syphilis News
Intro
Syphilis is a chronic bacterial sexually transmitted infection (STI); the syphilis syndemic refers to the clustering of syphilis, congenital syphilis, substance use disorder, mental illness, and other STIs including HIV, gonorrhea, and chlamydia. SAMHSA has issued a Dear Colleagues letter about the use of grant funds to address the syphilis syndemic. Please refer to the list of resources below for additional information.
January 30, 2024 Dear Colleague Letter – Syphilis (PDF | 270 KB).
May 15, 2024 Dear Opioid Treatment Program (OTP) Directors – Syphilis (PDF | 318 KB)
For questions regarding the use of SAMHSA grant funds to address the syphilis syndemic, please email syphilisFAQ@samhsa.hhs.gov.
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Strategic Plans and Calls to Action
General Facts and Information
Training
- National STD Curriculum
- NNPTC’s Clinical Consultation Network for licensed healthcare professionals and STD program staff
- Integrating Syphilis Programming Into Behavioral Healthcare Settings (One hour, 28 minutes): A webinar on SAMHSA’s funding and resources to address the syphilis syndemic and a detailed examination of congenital syphilis including an overview of syphilis (causes, transmission, stages), diagnosis and treatment options, trends, and resources that medical providers and behavioral health practitioners may use to meet the needs of individuals seeking services.
Screening, Testing, and Treatment
- STI Treatment Guidelines
- Guidelines and Best Practices and STD Treatment (Tx) Guide App
- CDC STI Screening Recommendations
- CDC's National HIV, STD, and Hepatitis Testing
- State Prenatal Syphilis Screenings Laws and Regulations
- Screening Syphilis Infection in Nonpregnant Adults and Adolescents
- U.S. Preventive Services Task Force STI Screening Recommendations for Syphilis Infections in Nonpregnant Adolescents and Adults
- Provider Resources to STI Treatment: Mobile App; Wall Chart; Pocket Guide
At-risk Populations
- Evidence-Based Toolkits for Rural Community Health
- Reduce the syphilis rate in females
- Reduce the syphilis rate in men who have sex with men
Pregnancy
- About Congenital Syphilis
- Blog: Effective Public Health Approaches to Reducing Congenital Syphilis
- Mother-to-child Transmission of Syphilis
People Impacted by the Criminal Justice System
Last Updated
Last Updated: 09/23/2025