EMD-31606

Single-particle
3.4 Å
EMD-31606
3D View Gallery
Deposition: 01/08/2021
Map released: 02/03/2022
Last modified: 16/03/2022
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-31606
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7fiy summary report (pdf.gz) Map and 7fiy FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the tirzepatide-bound human GIPR-Gs complex

EMD-31606

Single-particle
3.4 Å
EMD-31606
3D View Gallery
Deposition: 01/08/2021
Map released: 02/03/2022
Last modified: 16/03/2022
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct, Bos taurus, Rattus norvegicus
Sample: Cryo-EM structure of the tirzepatide-bound human GIPR-Gs complex
Fitted models: 7fiy

Deposition Authors: Zhao FH, Zhou QT, Cong ZT, Hang KN, Zou XY, Zhang C, Chen Y, Dai AT, Liang AY, Ming QQ, Wang M, Chen LN, Xu PY, Chang RL, Feng WB, Xia T, Zhang Y , Wu BL, Yang DH, Zhao LH, Xu HE , Wang MW
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P , Chang R, Feng W, Xia T, Zhang Y , Wu B , Yang D , Zhao L , Xu HE , Wang MW
(2022) Nat Commun , 13 , 1057 - 1057
PUBMED: 35217653
DOI: doi:10.1038/s41467-022-28683-0
ISSN: 2041-1723