FORM GUIDE: Joe Cokanasiga tips the scales, Jonny May has been nicknamed 'Forrest Gump' and Owen Farrell will not get distracted

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Eddie Jones has rung the changes for England against Italy, with five players coming into the team that lost to Wales at the Principality Stadium.

Sportsmail's NIK SIMON takes at look at which players can make a difference in England's penultimate Six Nations clash. 

England will be looking to bounce back against Italy after defeat by Wales in their last game

ELLIOT DALY 

AGE: 26 CAPS: 28

Likely to step in as a second playmaker in a backline dominated by heavyweights.  

JOE COKANASIGA 

AGE: 21 CAPS: 3

Tips the scales at 18st 3lb and clocks speeds of 10metres per second over 50m.

Joe Cokanasiga is granted his Six Nations debut and is a powerful and direct runner

MANU TUILAGI 

AGE: 27 CAPS: 30

Eddie Jones compares centre pairing to Bok heavies Francois Steyn and Jaque Fourie.

BEN TE'O 

AGE: 32 CAPS: 16

Questions over fitness as league convert makes his first appearance since January. 

Worcester centre Ben Te'o has returned after seven weeks out injured and will start

JONNY MAY

AGE: 28 CAPS: 43

Speedster has been nicknamed Forrest Gump after running in 12 tries in 13 Tests. 

OWEN FARRELL

AGE: 27 CAPS: 68

Unlikely to be distracted by awkward questions about Saracens’ salary cap inquiry. 

Owen Farrell is unlikely to be distracted by the inquiry into Saracens' salary cap

BEN YOUNGS

AGE: 29 CAPS: 83

Surprise selection at No 9 given lack of Test experience for back-up Dan Robson. 

ELLIS GENGE

AGE: 24 CAPS: 7

Described as a streetfighter. Destructive carrier makes his first Six Nations start.  

Ellis Genge (left) and Kyle Sinckler will start in front row together for England for the first time

JAMIE GEORGE

AGE: 28 CAPS: 35

More tackles than any other front-row forward so far — missing just one in 54. 

KYLE SINCKLER

AGE: 25 CAPS: 20 

All eyes on his discipline after conceding costly penalties in defeat by Wales. 

JOE LAUNCHBURY

AGE: 27 CAPS: 25

Baby-faced assassin called up following injuries to Courtney Lawes and Maro Itoje.

Lock Joe Launchbury has been selected after injuries to Courtney Lawes and Maro Itoje

GEORGE KRUIS

AGE: 29 CAPS: 30

Heartbeat of England’s fine lineout which was one of few successes against Wales.

BRAD SHIELDS

AGE: 27 CAPS: 6

Opportunity to make a World Cup claim after stuttering start to career in England.

TOM CURRY

AGE: 20 CAPS: 8

Likely to overtake Mark Wilson as England’s top tackler after star showing in Wales.

Young flanker Tom Curry was brilliant against Wales and also added a try in the first half

BILLY VUNIPOLA

AGE: 26 CAPS: 39

Carried the ball 40 times in opening three rounds. Sinckler is second on 19.

SUBSTITUTES: Cowan-Dickie, Moon, Cole, Hughes, Wilson, Robson, Ford, Slade.

ITALY: Hayward; Padovani, Campagnaro, Morisi, Esposito; Allan, Tebaldi; Lovotti, Bigi, Ferrari, Ruzza, Budd, Negri, Parisse (capt), Steyn. Subs: Ghiraldini, Traore, Pasquali, Sisi, Polledri, Palazzani, McKinley, Castello.