Savannah Guthrie's missing mother Nancy does not have medication she needs to survive, worried Today show host Jenna Hager revealed on Monday.
Speaking 36 hours after the 84-year-old's disappearance from her $1 million home in Tucson, Arizona, Hager said: 'I know her personally. And we want to just report, too, that she takes daily medication and she needs them for survival.
'She's without her medication. We are thinking of our dearest, dearest Savannah and her whole family right now in our prayers.' The Daily Mail understands that Nancy does not have dementia or suffer from any form of cognitive decline.
Earlier on Monday, Today reported that the FBI is 'aware' of Nancy's disappearance, with homicide detectives investigating after 'concerning' evidence was found at her home.
The morning show made the disappearance of Nancy their top story on Monday.
NBC's top crime expert Tom Winter said: 'The FBI is also aware of this case... given the nature of what was found at the scene
'That's what has got them so concerned.'
Winter added: 'We are withholding some details, as we would do with any investigation, to make sure the investigation could go forward without us interfering in it.
Guthrie, 54, was not at work on Monday but issued a statement via Today, saying: 'I want to thank everyone for the thoughts, prayers, and messages of support. Right now, our focus remains on the safe return of our dear mom.
'We thank law enforcement for their hard work on this case and encourage anyone, anyone with information to contact the Pima County Sheriff's office at 520-351-4900.'
Nancy was last seen in the Catalina Foothills area of Tucson around 9:45pm MST Saturday night.
Jenna Bush Hager appeared tearful on Today Monday morning as she revealed Savannah Guthrie's missing mother Nancy, 84, does not have medication she needs to survive
Today host Savannah Guthrie with her 84-year-old mother Nancy, who went missing from her Arizona home on Saturday night. The disappearance was the top story on Monday's show
Today host Craig Melvin said Nancy Guthrie's disappearance was 'deeply personal' to the hosts and crew of the show and shared a statement from Savannah Guthrie herself
Host Craig Melvin looked concerned as he discussed the disappearance of Savannah Guthrie's mother Nancy, as co-host Sheinelle Jones looked on
No further details of the 'concerning evidence' found at Nancy's home have been shared.
Today revealed that Customs and Border Patrol have joined sheriff's deputies in the hunt for Nancy, whose home sits close to the Mexican border.
Drones and a sheriff's plane have been deployed to try and track her down.
Pima County Sheriff Chris Nanos said the search for Nancy is still being treated as a search and rescue operation but was unable to rule out the possibility of foul play.
Investigators said Nancy was not showing any signs of cognitive issues around the time of her disappearance.
Host Craig Melvin conveyed how close to home the story was to the Today team, telling viewers: 'This is very concerning to us.
'We don't typically get involved at a scene like this, but it's very concerning.'
Melvin opened the broadcast by saying Nancy's disappearance was 'deeply personal' to the hosts and crew of Today.
Nancy Guthrie is pictured enjoying a drink in a photo shared by her daughter Savannah on Instagram
Guthrie is very close to her mother and has been photographed with her on the set of Today.
She regularly shares photos of herself enjoying her free time with her mother.
Guthrie's father Charles died of a heart attack when she was 16-years-old.
She has two older siblings - a sister called Annie and a brother called Camron.
