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Synthetic Biology

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  • Quantitative measurement of synthetic repression curves reveals design challenges for genetic circuit engineering under growth arrest
    John P Marken, Mark L Prator, Bruce A Hay, Richard M Murray
    bioRxiv 2026.02.01.703179; doi: https://doi.org/10.64898/2026.02.01.703179 New Results
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  • Fine-tuned synthetic transcription factors for production of 3′ phosphoadenosine-5′-phosphosulfate in yeast
    Madhushruti Borah, Shanna Gu, Essa M. Saied, Christoph Arenz, Mattheos A Koffas, Gita Naseri
    bioRxiv 2026.02.02.703094; doi: https://doi.org/10.64898/2026.02.02.703094 New Results
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  • Genome-wide screening reveals producer-cell modifications that improve virus-like particle production and delivery potency
    Diana Ly, Hyewon Jang, Adhiraj Goel, Arnav Singh, Aditya Raguram
    bioRxiv 2025.10.07.681010; doi: https://doi.org/10.1101/2025.10.07.681010 New Results
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  • Topological reprogramming transforms an integral membrane oligosaccharyltransferase into a water-soluble glycosylation catalyst
    Yong Hyun Kwon, Ljubica Mihaljevic, Keehun Kim, David Edwin Kim, Thomas C. Donahue, Erik J. Bidstrup, Chandra K. Bandi, Belen Sotomayor, Sophia W. Hulbert, Kathryn A. A. Myers, Anru Tian, Mariah Culpepper, Dario Mizrachi, Thapakorn Jaroentomeechai, Henrik Clausen, Michael Jewett, David Baker, Matthew P DeLisa
    bioRxiv 2026.01.30.702934; doi: https://doi.org/10.64898/2026.01.30.702934 New Results
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  • Molecular Bonsai: Elucidating the design principles for engineering plant organ size
    Tawni A Bull, Jared Van Blair, Sam Sutton, Hadley Colwell, Arjun Khakhar
    bioRxiv 2025.06.22.660808; doi: https://doi.org/10.1101/2025.06.22.660808 New Results
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  • Genome Position Does Not Impact Transgene Expression Efficiency in the Ancient Red Alga Cyanidioschyzon merolae
    Kaian Teles, Gordon B. Wellman, Yuhan Zhang, Bárbara Bastos de Freitas, Viktor A. Slat, Martha R. Stark, Lecong Zhou, Perry J. Blackshear, Stephen D. Rader, Kyle J. Lauersen
    bioRxiv 2026.01.31.703004; doi: https://doi.org/10.64898/2026.01.31.703004 New Results
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  • Development of a Fluorescent RNA Biosensor for Dual Detection of cGAMP and c-di-GMP Signals in Live Bacteria
    Madeline M. Mumbleau, Ming C. Hammond
    bioRxiv 2026.01.30.702909; doi: https://doi.org/10.64898/2026.01.30.702909 New Results
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  • Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation
    Tom Copeman, John H.C. Fong, Joshua Mayne, Thomas E Gorochowski, S Rodriguez-Conde, Tom Ellis, Francesca Ceroni
    bioRxiv 2025.12.15.694402; doi: https://doi.org/10.64898/2025.12.15.694402 New Results
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  • A coupled fluorescence assay for high-throughput screening of polyurethane-degrading enzymes
    Liujun Yang, Xianjun Deng, Renju Liu, Jianyang Li, Junyao Zhai, Xiaoxiao Ma, Arthur K.L. Lin, Jiguang Wang, Zongze Shao, Hongyuan Lu
    bioRxiv 2025.07.09.663332; doi: https://doi.org/10.1101/2025.07.09.663332 New Results
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  • Quantitative modeling reveals sources of variability in transcriptional activation assays
    Mark Greenwood, Kenneth F. Reardon, Ashok Prasad
    bioRxiv 2026.01.30.702786; doi: https://doi.org/10.64898/2026.01.30.702786 New Results
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