Cancer Biology

Altered Crosstalk of Bacterial Lipopolysaccharide with Immune Cells in Colorectal Cancer Compared to Paired Adjacent Intestinal Tissue
Asa Walberg, Anna Maria Reuss, Reihane Ziadlou, Celine Mamie, Claudia Gottier, Anna White, Mohammadmilad Ameri, Marie-Charlotte Brueggen, Matthias Turina, Michaela Ramser, Paulina Wawrzyniak, Maria Walker, Luca Truscello, Adriano Aguzzi, Anne Mueller, Barbara Hubeli, Yasser Morsy, Michael Scharl

bioRxiv 2026.02.01.701966; doi: https://doi.org/10.64898/2026.02.01.701966 New Results

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Epigenetic Gatekeeping of Intestinal Stem Cell Transformation
Alireza Lorzadeh, Sweta Sharma, George Ye, Sabrina Rabaya, Yun Jee Kang, Ramesh Shivdasani, Unmesh Jadhav

bioRxiv 2026.01.31.702974; doi: https://doi.org/10.64898/2026.01.31.702974 New Results

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Cross-species graph-embedding unmasks the ageing microenvironment as a key determinant of pancreatic cancer malignant cell biology and therapy response
Joaquin Araos Henriquez, Muntadher Jihad, Amir Jassim, Eloise G Lloyd, Weike Luo, Judhell S Manansala, Sneha Harish, Sara Pinto Teles, Priscilla SW Cheng, Gianluca Mucciolo, Wenlong Li, Marta Zaccaria, Debasmita Mukherjee, Rebecca Brais, Sally Mills, Paul M Johnson, Mireia Vallespinos, Richard J Gilbertson, Giulia Biffi

bioRxiv 2026.02.02.703350; doi: https://doi.org/10.64898/2026.02.02.703350 New Results

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YAP disrupts bile acid homeostasis to drive cancer-associated cachexia
Madeline L Webb, Mikaela Wong, Anthony P Karamalakis, Yuchen Liu, Kimberley J Evason, Kira X Sun, Kristin Brown, Jay R Black, Yingzi Yang, Andrew G Cox

bioRxiv 2026.02.01.702698; doi: https://doi.org/10.64898/2026.02.01.702698 New Results

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Functional genomics identifies therapeutic options, biomarkers, and resistance mechanisms for high-grade gliomas
Wan-Hsin Lin, Farhad Kosari, James B. Smadbeck, Michael T. Barrett, Ryan W. Feathers, Jamie Hall, Dorsay Sadeghian, Sotiris Sotiriou, Sarah H. Johnson, Faye R. Harris, Taylor Berry, Alexa F. McCune, Stephen James Murphy, Lindsey Kinsella, Lauren E. Haydu, Diogo Moniz-Garcia, Shannon P. Fortin Ensign, Lin Yang, Angela R. Emanuel, Leila A. Jones, Janet L. Schaefer-Klein, Christiane M. Ida, Marcela A. Salomao, Wendy J. Sherman, Alyx B. Porter, Steven S Rosenfeld, Sani H. Kizilbash, Kurt A. Jaeckle, Maciej M. Mrugala, Aaron S Mansfield, Mitesh S Borad, Bernard R. Bendok, Terry C. Burns, Alfredo Quinones-Hinojosa, John C. Cheville, George Vasmatzis, Panos Z Anastasiadis

bioRxiv 2026.02.01.701806; doi: https://doi.org/10.64898/2026.02.01.701806 New Results

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Clonal morphology-guided combination therapies overcome heterogeneity-driven drug tolerance
Xiaoxi Li, Ling Liu, Yuanyuan Yan, Mengfang Yang, Lingli Luo, Yong Jiang, Weijun Ren

bioRxiv 2026.01.31.703021; doi: https://doi.org/10.64898/2026.01.31.703021 New Results

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MNRR1 is required for Triple Negative Breast Cancer growth and metastasis and can be targeted by repurposed drugs.
Mrunal Sathe, Paige Minchella, Caleb Vegh, Mithra Modikuppam Dharmalingam, Vignesh Pasupathi, Yue Xi, Sagarika Rai, Mrunmayee Patil, Habiba Elshenawy, Sydney Rudolph, Gaurav Bhatti, Adi L Tarca, Neeraja Purandare, Andrew Fribley, Lawrence I. Grossman, Siddhesh Aras

bioRxiv 2026.01.31.703055; doi: https://doi.org/10.64898/2026.01.31.703055 New Results

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Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74⁺ lipid-associated macrophage niche driving polymetastatic breast cancer
Jacob Insua-Rodríguez, Pascal Naef, Hannah Savage, Isam Adam, Sung Kook Chun, Axel A Almet, Gautham Prabhakar, Sharon Kwon, Cassandra G Sweet, Sevilla Farah Hennessey, Angela Lincy Prem Antony Samy, Hamad Alshetaiwi, Maren Pein, Sharmila Mallya, Delia F Tifrea, Declan M Edwards, Angela Gomez-Arboledas, Zander Esh, Carina Sandoval, Katrina Taylor Evans, Alex Hsu, Victoria Chen Mai, Ngoc Bao Kim Nguyen, Erika Zagni, Aaron Longworth, Paige Vail Halas, Aaron Simon, Cholsoon Jang, Ahmed Mohyeldin, Robert Andrew Edwards, Qing Nie, Selma Masri, Kai Kessenbrock, Devon Ann Lawson

bioRxiv 2026.01.31.701004; doi: https://doi.org/10.64898/2026.01.31.701004 New Results

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Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition
Chiara Asselborn, Agata N Makar, Jair G Marques Jr., Aslihan B Akan, Athanasia Yiapanas, Carrie Jennings, Ana Perez Lopez, Jimi Wills, Asier Unciti-Broceta, Kevin B Myant, Alex von Kriegsheim

bioRxiv 2026.01.31.702998; doi: https://doi.org/10.64898/2026.01.31.702998 New Results

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Tumor cell-intrinsic stress states drive sensitivity to CAR T cell-therapy in pancreatic cancer
Julia Fröse, Evelyn Chen, Charles A. Whittaker, Paul Leclerc, Sean Doherty, Adam Langenbucher, Jasmine Shao, Riley D. Hellinger, Daniel Goulet, Tuomas Tammela, Francisco J. Sánchez-Rivera, Michael T. Hemann

bioRxiv 2025.07.24.666408; doi: https://doi.org/10.1101/2025.07.24.666408 New Results

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Cancer Biology

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