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> endobj 3421 0 obj <

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> endobj 3454 0 obj <

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> endobj 3465 0 obj <

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-0.002 Tw 12 0 0 12 93.3487 702.9103 Tm [(H)4 (E)3 (R)-1 (Z)13 (U)4 (M)1 (A)4 ( is)1 ( in)2 (d)2 (ic)-4 (a)6 (te)6 (d)2 (: )]TJ EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 0 Tw 3 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 0.002 Tc -0.002 Tw 1.5 0 Td [(I)15 (n )-8 (c)6 (o)2 (mb)2 (in)2 (a)6 (tio)2 (n)2 ( w)4 (ith)2 ( p)2 (a)6 (c)6 (l)-10 (ita)6 (x)-8 (e)6 (l f)5 (o)2 (r)5 ( f)5 (ir)5 (s)1 (t)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc -0.002 Tw 15.86 0 Td [(lin)2 (e)6 ( tr)5 (e)6 (a)6 (tm)-10 (e)6 (n)2 (t o)2 (f)5 ( H)4 (E)3 (R)-1 (2)]TJ 0 Tc 0 Tw 9.36 0 Td [(-)3 (ove)-6 (r)3 (e)4 (x)-10 (pr)3 (e)4 (s)-1 (s)-1 (i)-2 (ng )]TJ -0.004 Tc 0.004 Tw -25.22 -1.17 Td [(m)-6 (et)-6 (as)-5 (t)-6 (at)-6 (i)-6 (c b)-4 (r)-1 (eas)-5 (t )-16 (can)-4 (c)-10 (er )]TJ EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 0 Tw -1.5 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 0.002 Tc -0.002 Tw 1.5 0 Td [(A)4 (s)1 ( a)6 ( s)1 (in)2 (g)12 (le )-4 (a)-4 (g)12 (e)6 (n)2 (t f)5 (o)-8 (r)5 ( tr)5 (e)6 (a)-4 (tme)6 (n)2 (t o)2 (f)5 ( H)4 (E)3 (R)-1 (2)]TJ 0 Tc 0 Tw 16.13 0 Td [(-)3 (ove)4 (r)3 (e)4 (x)-10 (pr)-7 (e)4 (s)-1 (s)-1 (i)-2 (ng)10 ( br)-7 (e)4 (a)4 (s)-1 (t)-2 ( c)-6 (a)4 (nc)4 (e)-6 (r)3 ( i)-2 (n pa)-6 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (ho )]TJ -0.004 Tc 0.004 Tw -16.13 -1.17 Td [(h)-4 (av)-4 (e r)-1 (e)-10 (cei)-6 (v)-4 (ed)-4 ( o)-4 (n)-14 (e o)-4 (r)-1 ( m)-6 (o)-4 (r)-11 (e ch)-4 (em)-6.1 (o)-3.9 (t)-6 (h)-4 (er)-11 (ap)-24 (y)16 ( r)-11 (e)-10 (g)6 (i)-6 (m)-6 (en)-14 (s)-5 ( f)-1 (o)-4 (r)-1 ( m)-6 (et)-6 (as)-5 (t)-6 (at)-6 (i)-6 (c d)-4 (i)-6 (s)-5 (eas)-15 (e. )]TJ EMC /P <>BDC -4.5 -1.66 Td [(S)-8 (el)-6 (ect)-6 ( p)-4 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( f)-1 (o)-4 (r)-1 ( t)-6 (h)-4 (e)-10 (r)-0.9 (ap)-14 (y )6 (b)-4 (as)-15 (ed)-4 ( o)-4 (n)-4 ( an )-14 (F)2 (D)-2 (A)]TJ 0 Tc 0 Tw 17.68 0 Td [(-)-7 (a)4 (ppr)-7 (ove)4 (d c)4 (om)-2 (pa)4 (ni)-2 (on di)-2 (a)-6 (g)10 (nos)-11 (t)-2 (i)-2 (c)4 ( f)3 (or)3 ( a )]TJ 11.52 0 0 11.52 491.1487 613.6303 Tm [(t)-3.2 (ra)-3.9 (s)3.6 (t)-3.3 (uz)6.5 (um)-3.2 (a)-3.9 (b )]TJ -34.531 -1.219 Td [(produc)-4 (t )]TJ /TT3 1 Tf 12 0 0 12 131.6287 599.5903 Tm [([)-1 (s)-1 (e)4 (e)4 ( D)2 (os)-1 (age)4 ( and A)1 (dm)2 (i)-2 (ni)-2 (s)-1 (t)-2 (r)-1 (at)-2 (i)-2 (on \()13 (2.1)]TJ -0.033 Tc 0.033 Tw 14.8 0 Td (\)])Tj /TT0 1 Tf 0 Tc 0 Tw 0.73 0 Td (. )Tj EMC /P <>BDC /TT1 1 Tf 14.04 0 0 14.04 93.3487 559.8703 Tm (2 )Tj -0.004 Tc 0.002 Tw 3.846 0 Td [(DO)-3.7 (S)-3.6 (AG)-3.8 (E)-3.7 ( AND AD)-8.5 (MI)-8.2 (NI)-8.1 (S)]TJ 0 Tc 0 Tw 11.308 0 Td [(TR)4.1 (A)4 (TI)4.4 (ON )]TJ EMC /Span <>BDC -0.002 Tc 0.002 Tw -15.153 -2 Td [(2)-6.3 (.1 )]TJ EMC /Span <>BDC -0.004 Tc 0.004 Tw 3.846 0 Td [(Pa)-8.3 (t)]TJ 0.001 Tc -0.003 Tw 1.444 0 Td [(i)-3 (e)0.5 (n)10 (t)0.7 ( S)1.5 (e)0.5 (l)5.5 (e)0.6 (c)0.6 (t)0.6 (i)5.6 (o)-3.3 (n )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw 12 0 0 12 93.3487 511.3903 Tm [(S)-4 (e)4 (l)-2 (e)4 (c)4 (t)-2 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( f)3 (or)3 ( H)2 (E)1 (R)-13 (Z)1 (U)2 (M)-1 (A)2 ( t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( b)-10 (a)4 (s)-1 (e)4 (d on )-10 (H)2 (E)1 (R)-3 (2 pr)3 (ot)-2 (e)4 (i)-2 (n ove)4 (r)3 (e)4 (x)-10 (pr)3 (e)4 (s)-11 (s)-1 (i)-2 (on or)3 ( H)2 (E)1 (R)-3 (2 g)10 (e)4 (n)-10 (e )]TJ 0.002 Tc -0.002 Tw 0 -1.16 TD [(a)6 (mp)2 (lif)5 (ic)6 (a)6 (tio)2 (n)2 ( in)2 ( tu)2 (mo)2 (r)5 ( s)1 (p)2 (e)6 (c)6 (ime)6 (n)2 (s )]TJ /TT3 1 Tf 0 Tc 0 Tw 13.66 0 Td [([)-1 (s)-1 (e)4 (e )-6 (I)3 (ndi)-2 (c)4 (at)-2 (i)-2 (ons)-1 ( and U)2 (s)-1 (ag)]TJ -0.004 Tc 0.014 Tw (e \()Tj 0 Tc 0 Tw 11.55 0 Td [(1)-10 (\))13 ( and C)-3 (l)-2 (i)-2 (ni)-2 (c)-6 (al)-2 ( St)-2 (udi)-2 (e)4 (s)-1 ( \()13 (14)]TJ -0.033 Tc 0.033 Tw 10.79 0 Td (\)])Tj /TT0 1 Tf 0 Tc 0 Tw 0.73 0 Td (. )Tj 0.001 Tc -0.001 Tw -36.73 -1.17 Td [(A)3 (sse)5 (ss)]TJ 0 Tc 0 Tw [(m)-2 (e)4 (nt)-2 ( of)3 ( H)2 (E)1 (R)-3 (2 pr)3 (o)-10 (t)-2 (e)4 (i)-2 (n ove)4 (r)3 (e)4 (x)-10 (pr)3 (e)4 (s)-1 (s)-1 (i)-2 (on a)4 (nd )-10 (H)2 (E)1 (R)-3 (2 g)10 (e)4 (n)-10 (e )4 (a)4 (m)-2 (pl)-2 (i)-2 (f)3 (i)-2 (c)4 (a)4 (t)-2 (i)-2 (on)-10 ( s)-1 (houl)-2 (d be)4 ( pe)4 (r)3 (f)3 (or)3 (m)-12 (e)4 (d )]TJ 0 -1.17 TD [(us)-1 (i)-2 (ng)10 ( F)-4 (D)2 (A)2 (-)3 (a)4 (pp)-10 (r)3 (ove)4 (d t)-2 (e)4 (s)-1 (t)-12 (s)-1 ( s)-1 (pe)4 (c)4 (i)-2 (f)3 (i)-2 (c)4 ( f)3 (or )-7 (br)3 (e)-6 (a)4 (s)-1 (t)-2 ( c)4 (a)4 (nc)-6 (e)4 (r)3 ( b)-20 (y)20 ( l)-2 (a)4 (bor)-7 (a)4 (t)-2 (or)3 (i)-2 (e)4 (s)-1 ( w)2 (i)-2 (t)-2 (h de)-6 (m)-2 (ons)-1 (t)-2 (r)3 (a)4 (t)-2 (e)4 (d )]TJ 0 -1.16 TD [(pr)3 (of)3 (i)-2 (c)4 (i)-2 (e)4 (nc)-16 (y)20 (. )-20 (I)13 (nf)3 (or)3 (m)-2 (a)4 (t)-2 (i)-2 (on )-10 (on t)-2 (he)4 ( F)6 (D)2 (A)-8 (-)3 (a)4 (ppr)3 (ov)-10 (e)4 (d t)-2 (e)4 (s)-11 (t)-2 (s)-1 ( f)3 (or)3 ( t)-2 (he)4 ( de)4 (t)-2 (e)4 (c)4 (t)-2 (i)-2 (on of )-7 (H)2 (E)-9 (R)-3 (2 pr)3 (ot)-2 (e)4 (i)-2 (n )]TJ 0 -1.17 TD [(ove)4 (r)3 (e)4 (x)-10 (pr)3 (e)4 (s)-1 (s)-1 (i)-2 (on a)4 (nd H)2 (E)1 (R)-13 (2 g)10 (e)4 (n)-10 (e)4 ( a)4 (m)-2 (pl)-2 (i)-2 (f)3 (i)-2 (c)4 (a)4 (t)-2 (i)-2 (on i)-2 (s)-1 ( a)-6 (va)4 (i)-2 (l)]TJ -0.004 Tc 0.004 Tw 21.33 0 Td [(ab)-4 (l)-6 (e at)-6 (: )]TJ EMC /Link <>BDC 0 Tc 0 Tw -21.33 -1.17 Td [(ht)-2 (t)-2 (p:)-2 (/)-2 (/)-2 (w)2 (w)2 (w)2 (.f)3 (da)4 (.g)10 (ov/)-2 (C)-3 (om)-12 (pa)4 (ni)-2 (onD)2 (i)-2 (a)-6 (g)10 (nos)-1 (t)-2 (i)-2 (c)4 (s)]TJ EMC /P <>BDC 17.5 0 Td (. )Tj EMC /P <>BDC -17.5 -1.66 Td [(I)13 (m)-2 (pr)3 (op)-10 (e)4 (r)3 ( a)4 (s)-1 (s)-11 (a)-16 (y)20 ( pe)4 (r)-7 (f)3 (or)3 (m)-2 (a)-6 (nc)4 (e)4 (, i)-2 (nc)4 (l)-2 (udi)-2 (n)-10 (g)10 ( us)-1 (e)4 ( of)3 ( s)-1 (ub)-10 (opt)-2 (i)-2 (m)-2 (a)4 (l)-2 (l)-12 (y )20 (f)3 (i)-2 (x)-10 (e)4 (d t)-2 (i)-2 (s)-1 (s)-1 (ue)4 (, f)3 (a)4 (i)-2 (l)-2 (ur)3 (e)4 ( t)-2 (o ut)-2 (i)-2 (l)-2 (i)-2 (z)-6 (e )]TJ T* [(s)-1 (pe)4 (c)4 (i)-2 (f)3 (i)-2 (e)4 (d r)-7 (e)4 (a)-6 (g)10 (e)4 (nt)-2 (s)-1 (, d)-10 (e)4 (vi)-2 (a)4 (t)-12 (i)-2 (on f)3 (r)3 (om)-2 ( s)-1 (pe)4 (c)4 (i)-2 (f)3 (i)-2 (c )-6 (a)4 (s)-1 (s)-1 (a)-16 (y)20 ( i)-12 (ns)-1 (t)-2 (r)3 (uc)4 (t)-2 (i)-2 (ons)-1 (, a)4 (nd f)3 (a)4 (i)-2 (l)-2 (ur)3 (e)4 ( t)-2 (o)-10 ( i)-2 (nc)4 (l)-2 (ude)4 ( a)4 (ppr)3 (opr)3 (i)-12 (a)4 (t)-2 (e )]TJ T* [(c)4 (ont)-2 (r)3 (ol)-2 (s)-1 ( f)3 (or)3 ( a)4 (s)-1 (s)-1 (a)-16 (y)20 ( v)-10 (a)4 (l)-2 (i)-2 (da)4 (t)-12 (i)-2 (on, c)4 (a)4 (n l)-2 (e)4 (a)4 (d t)-2 (o unr)-7 (e)4 (l)-2 (i)-2 (a)4 (bl)-2 (e)4 ( r)3 (e)4 (s)-1 (ul)-2 (t)-2 (s)-1 (. )]TJ EMC /Span <>BDC /TT1 1 Tf -0.002 Tc 14.04 0 0 14.04 93.3487 351.6703 Tm [(2)-6.3 (.2 )]TJ EMC /Span <>BDC -0.001 Tc -0.001 Tw 3.846 0 Td [(R)3 (e)-1.4 (c)-1.5 (o)-5.3 (m)3 (m)11.5 (e)-1.5 (n)-0.6 (de)-1.5 (d D)3 (o)-5.2 (s)-5.2 (e)7.1 (s)-5.2 ( a)-5.2 (n)-0.6 (d)-0.6 ( S)-0.6 (c)7.1 (h)-0.6 (e)-1.4 (d)-0.6 (u)8 (l)-5.1 (e)-1.4 (s )]TJ EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 0 Tw 12 0 0 12 129.3487 330.6703 Tm <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT1 1 Tf 1.5 0 Td [(D)2 (o n)-4 (ot)3 ( ad)-4 (m)13 (i)-2 (n)-4 (i)-2 (s)-1 (t)3 (e)4 (r)4 ( as)-1 ( an)-14 ( i)-2 (n)-4 (t)3 (r)4 (ave)4 (n)-4 (ou)-4 (s)-1 ( p)-4 (u)-4 (s)9 (h)-4 ( or)4 ( b)-4 (o)10 (l)-2 (u)-4 (s)-1 (. D)2 (o n)-4 (ot)3 ( m)13 (i)-2 (x H)-2 (E)-3 (R)2 (Z)-3 (U)2 (M)4 (A)2 ( w)-8 (i)-2 (t)3 (h )]TJ -0.004 Tc 0.004 Tw T* [(o)-4 (t)-1 (h)-8 (er d)-8 (ru)-8 (g)-4 (s)-5 (. )]TJ EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 0 Tw -1.5 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT1 1 Tf -0.003 Tc 0.003 Tw 1.5 0 Td [(D)-1 (o)-3 ( n)-7 (o)-3 (t s)-4 (u)-7 (b)-7.1 (s)-3.9 (ti)-5 (tu)-7 (te)1 ( H)-5 (E)-6 (R)-1 (Z)4 (U)-1 (M)-9 (A)-1 ( \(t)-10 (r)1 (a)-3.1 (s)-4 (tu)-7 (z)1 (u)-17 (m)10 (a)-3 (b)]TJ 0 Tc 0 Tw 18.78 0 Td (-)Tj 0.004 Tc -0.004 Tw 0.33 0 Td [(pkr)8 (b)]TJ -0.004 Tc 0.004 Tw [(\))-1 ( f)-11 (o)-4 (r o)-4 (r w)-12 (i)-6 (t)-1 (h )]TJ 0 Tc 0 Tw 7.57 0 Td [(ad)-4 (o-)]TJ 0.004 Tc -0.004 Tw 1.89 0 Td [(t)7 (r)8 (a)4 (s)3 (t)7 (uz)8 (um)17 (a)4 (b )]TJ 0 Tw -28.57 -1.17 Td [(e)-2 (m)17 (t)7 (a)4 (ns)3 (i)2 (ne)8 (. )]TJ EMC /P <>BDC /TT3 1 Tf 0 Tc -4.5 -1.67 Td [(A)1 (dj)-2 (uv)4 (ant)-2 ( T)-4 (r)-1 (e)4 (at)-2 (m)2 (e)4 (nt)-2 (, B)1 (r)-1 (e)-6 (as)-1 (t)-2 ( C)-3 (anc)4 (e)4 (r)-1 (: )]TJ EMC /P <>BDC /TT0 1 Tf 0 -1.66 TD [(A)2 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 ( a)4 (c)4 (c)4 (or)3 (di)-2 (n)-10 (g)10 ( t)-2 (o )-10 (t)-2 (he)4 ( f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng)10 ( dos)-1 (e )-6 (a)4 (nd s)-1 (c)-6 (he)4 (dul)-2 (e)4 ( f)3 (or )-7 (a)4 ( t)-2 (ot)-2 (a)4 (l)-2 ( of)3 ( 52 w)-8 (e)4 (e)4 (ks)-1 ( of)3 ( H)2 (E)1 (R)-13 (Z)11 (U)2 (M)-1 (A )]TJ -0.004 Tc 0 -1.17 TD [(t)-6 (h)-4 (er)-1 (ap)-24 (y)16 (: )]TJ EMC /P <>BDC 0 Tc 0 -1.67 TD [(D)2 (ur)3 (i)-2 (ng a)4 (nd f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (n)-10 (g)10 ( pa)-6 (c)4 (l)-2 (i)-2 (t)-2 (a)4 (x)-10 (e)4 (l)-2 (, doc)4 (e)4 (t)-2 (a)4 (x)-10 (e)4 (l)-2 (, or)3 ( doc)4 (e)4 (t)-2 (a)4 (x)-10 (e)4 (l )-2 (a)4 (nd c)4 (a)-6 (r)3 (bopl)-2 (a)4 (t)-2 (i)-2 (n: )]TJ EMC /Lbl <>BDC /C2_0 1 Tf 3 -1.71 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(I)13 (ni)-2 (t)-2 (i)-2 (a)4 (l)-2 ( dos)-1 (e)4 ( of)3 ( 4 m)-12 (g)10 (/)-2 (k)-10 (g)10 ( a)4 (s)-11 ( a)4 (n i)-2 (nt)-2 (r)3 (a)4 (ve)4 (nous)-1 ( i)-2 (nf)3 (us)-1 (i)-2 (on )-10 (ove)4 (r)3 ( 90 )]TJ 0.002 Tc -0.002 Tw [(min)2 (u)2 (te)6 (s)1 ( th)2 (e)6 (n)2 ( a)6 (t 2 )]TJ -0.01 Tc 0.01 Tw 30.47 0 Td [(m)-12 (g/)-12 (k)-20 (g a)-6 (s )]TJ 0 Tc 0 Tw -30.47 -1.17 Td [(a)4 (n i)-2 (nt)-2 (r)3 (a)4 (ve)4 (nous)-1 ( i)-2 (nf)3 (us)-1 (i)-2 (on o)-10 (ve)4 (r)3 ( 30 m)-2 (i)-2 (nut)-2 (e)4 (s)-1 ( w)2 (e)4 (e)4 (kl)-22 (y)20 ( d)-10 (ur)3 (i)-2 (ng)10 ( c)4 (h)-10 (e)4 (m)-2 (ot)-2 (he)4 (r)-7 (a)4 (p)-20 (y)20 ( f)3 (or)3 ( t)-12 (he)4 ( f)3 (i)-2 (r)3 (s)-1 (t )]TJ 0 -1.17 TD (12 )Tj -0.004 Tc 0.004 Tw [(w)-2 (eek)-4 (s)-5 ( \()-1 (p)-14 (acl)-6 (i)-6 (t)-6 (ax)-14 (el)-6 ( o)-4 (r)-1 ( d)-4 (o)-4 (cet)-6 (ax)-13.9 (el)-6 (\))-1 ( o)-4 (r)-1 ( 1)-4 (8 )-4 (w)-2 (e)-10 (ek)-4 (s)-5 ( \()-1 (d)-14 (o)-4 (cet)-6 (ax)-14 (el )-6 (an)-4 (d )]TJ 0 Tc 0 Tw 25.15 0 Td [(c)4 (a)-6 (r)3 (bopl)-2 (a)4 (t)-2 (i)-2 (n\))-7 (. )]TJ EMC /Lbl <>BDC /C2_0 1 Tf -26.65 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(O)2 (ne)4 ( w)2 (e)-6 (e)4 (k f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (n)-10 (g)10 ( t)-2 (he)4 ( l)-2 (a)4 (s)-1 (t)-2 ( w)2 (e)4 (e)4 (kl)-22 (y)20 ( dos)-1 (e)4 ( o)-10 (f)3 ( H)2 (E)1 (R)-13 (Z)11 (U)2 (M)-1 (A)2 (, )-10 (a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)]TJ -0.002 Tc 0.002 Tw 27.16 0 Td [(r)1 ( HE)-1 (R)-15 (Z)9 (UM)-3 (A )-10 (a)2 (t )]TJ 0 Tc 0 Tw -27.16 -1.17 Td [(6 m)-2 (g)10 (/)-2 (k)-10 (g)10 ( a)4 (s)-1 ( a)4 (n i)-2 (nt)-2 (r)-7 (a)4 (ve)4 (nou)-10 (s)-1 ( i)-2 (nf)3 (us)-1 (i)-2 (on ove)4 (r)3 ( 30\22690 )]TJ -0.004 Tc 0.004 Tw [(m)-6 (i)-6 (n)-4 (u)-4 (t)-6 (es)-5 ( ev)-4 (er)-21 (y)16 ( t)-6 (h)-4 (r)-11 (ee w)-12 (eek)-3.9 (s)-5.1 (. )]TJ EMC /Artifact <>BDC 0 Tc 0 Tw 14.75 -5.8 Td (3)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 31.3487 26.3903 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4538 0 obj <>>>/Resources 4507 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 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This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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q 1 0 0 1 -21.168182 -16.96875 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 104.4482 439.2487 Tm ( )Tj 17.282 0 Td ( )Tj 9.163 0 Td ( )Tj 10.631 0 Td ( )Tj ET Q 72 435.72 0.72 0.72 re f 72.72 435.72 48.96 0.72 re f 121.68 435.72 0.72 0.72 re f 122.4 435.72 162 0.72 re f 284.4 435.72 0.72 0.72 re f 285.12 435.72 116.64 0.72 re f 401.76 435.72 0.72 0.72 re f 402.48 435.72 116.64 0.72 re f 519.12 435.72 0.72 0.72 re f 72 417 0.72 18.72 re f 72 416.28 0.72 0.72 re f 72 416.28 0.72 0.72 re f 72.72 416.28 48.96 0.72 re f 121.68 417 0.72 18.72 re f 121.68 416.28 0.72 0.72 re f 122.4 416.28 162 0.72 re f 284.4 417 0.72 18.72 re f 284.4 416.28 0.72 0.72 re f 285.12 416.28 116.64 0.72 re f 401.76 417 0.72 18.72 re f 401.76 416.28 0.72 0.72 re f 402.48 416.28 116.64 0.72 re f 519.12 417 0.72 18.72 re f 519.12 416.28 0.72 0.72 re f 519.12 416.28 0.72 0.72 re f q 1 0 0 1 -21.168182 -16.96875 cm BT /TT0 1 Tf 3 Tr 9.96 0 0 9.96 96.0482 423.8888 Tm ( )Tj /C2_0 1 Tf 0.003 Tc 23 0 Td <0003>Tj 8.181 0 Td <0003>Tj /TT0 1 Tf 0 Tc 6.313 0 Td ( )Tj -37.458 -1.157 Td ( )Tj 0.006 Tc -0.003 Tw 11.699 0 Td ( )Tj 0 Tc 0 Tw 9.747 0 Td ( )Tj -21.482 -1.157 Td ( )Tj 0.006 Tc -0.003 Tw 7.373 0 Td [( )-1783.1 ( )-1783.2 ( )]TJ 16.289 0 Td ( )Tj 7.554 0 Td ( )Tj 0 Tc 0 Tw 8.482 0 Td [( )-3557.9 ( )]TJ /TT1 1 Tf 12 0 0 12 122.5682 375.2887 Tm [( )-830 ( )]TJ 18.2 0 Td ( )Tj 15.57 0 Td ( )Tj 11.04 0 0 11.04 124.0082 352.6087 Tm ( )Tj 8.348 0 Td ( )Tj 20.457 0 Td ( )Tj ET Q 72 349.08 0.72 0.72 re f 72 349.08 0.72 0.72 re f 72.72 349.08 60.24 0.72 re f 132.96 349.08 0.72 0.72 re f 133.68 349.08 122.76 0.72 re f 256.44 349.08 0.72 0.72 re f 257.16 349.08 282.12 0.72 re f 539.28 349.08 0.72 0.72 re f 539.28 349.08 0.72 0.72 re f 72 330.36 0.72 18.72 re f 132.96 330.36 0.72 18.72 re f 256.44 330.36 0.72 18.72 re f 539.28 330.36 0.72 18.72 re f q 1 0 0 1 -21.168182 -16.96875 cm BT /TT1 1 Tf 3 Tr 11.04 0 0 11.04 124.0082 333.2887 Tm ( )Tj 8.348 0 Td ( )Tj 14.5 0 Td ( )Tj 13.196 0 Td ( )Tj ET Q 72 329.64 0.72 0.72 re f 72.72 329.64 60.24 0.72 re f 132.96 329.64 0.72 0.72 re f 133.68 329.64 122.76 0.72 re f 256.44 329.64 0.72 0.72 re f 257.16 329.64 140.64 0.72 re f 397.8 329.64 0.72 0.72 re f 398.52 329.64 140.76 0.72 re f 539.28 329.64 0.72 0.72 re f 72 310.92 0.72 18.72 re f 132.96 310.92 0.72 18.72 re f 256.44 310.92 0.72 18.72 re f 397.8 310.92 0.72 18.72 re f 539.28 310.92 0.72 18.72 re f q 1 0 0 1 -21.168182 -16.96875 cm BT /TT1 1 Tf 3 Tr 11.04 0 0 11.04 137.6868 313.8487 Tm ( )Tj 8.359 0 Td ( )Tj 10.598 0 Td [( )-4935 ( )]TJ 12.805 0 Td [( )-4935 ( )]TJ ET Q 72 310.2 0.72 0.72 re f 72.72 310.2 60.24 0.72 re f 132.96 310.2 0.72 0.72 re f 133.68 310.2 122.76 0.72 re f 256.44 310.2 0.72 0.72 re f 257.16 310.2 73.68 0.72 re f 330.84 310.2 0.72 0.72 re f 331.56 310.2 66.24 0.72 re f 397.8 310.2 0.72 0.72 re f 398.52 310.2 73.68 0.72 re f 472.2 310.2 0.72 0.72 re f 472.92 310.2 66.36 0.72 re f 539.28 310.2 0.72 0.72 re f 72 291.6 0.72 18.6 re f 132.96 291.6 0.72 18.6 re f 256.44 291.6 0.72 18.6 re f 330.84 291.6 0.72 18.6 re f 397.8 291.6 0.72 18.6 re f 472.2 291.6 0.72 18.6 re f 539.28 291.6 0.72 18.6 re f q 1 0 0 1 -21.168182 -16.96875 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 104.4482 294.5287 Tm ( )Tj 1.87 -1.152 Td ( )Tj 12.392 0.576 Td ( )Tj 5.739 0 Td ( )Tj 6.152 0 Td ( )Tj 6.652 0 Td ( )Tj 6.152 0 Td ( )Tj ET Q 72 290.88 0.72 0.72 re f 72.72 290.88 60.24 0.72 re f 132.96 290.88 0.72 0.72 re f 133.68 290.88 122.76 0.72 re f 256.44 290.88 0.72 0.72 re f 257.16 290.88 73.68 0.72 re f 330.84 290.88 0.72 0.72 re f 331.56 290.88 66.24 0.72 re f 397.8 290.88 0.72 0.72 re f 398.52 290.88 73.68 0.72 re f 472.2 290.88 0.72 0.72 re f 472.92 290.88 66.36 0.72 re f 539.28 290.88 0.72 0.72 re f 72 259.56 0.72 31.32 re f 132.96 259.56 0.72 31.32 re f 256.44 259.56 0.72 31.32 re f 330.84 259.56 0.72 31.32 re f 397.8 259.56 0.72 31.32 re f 472.2 259.56 0.72 31.32 re f 539.28 259.56 0.72 31.32 re f q 1 0 0 1 -21.168182 -16.96875 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 104.4482 262.4887 Tm ( )Tj 4.033 -1.152 Td ( )Tj 10.229 0.576 Td ( )Tj 5.739 0 Td ( )Tj 6.152 0 Td ( )Tj 6.402 0 Td ( )Tj 6.402 0 Td ( )Tj ET Q 72 258.84 0.72 0.72 re f 72.72 258.84 60.24 0.72 re f 132.96 258.84 0.72 0.72 re f 133.68 258.84 122.76 0.72 re f 256.44 258.84 0.72 0.72 re f 257.16 258.84 73.68 0.72 re f 330.84 258.84 0.72 0.72 re f 331.56 258.84 66.24 0.72 re f 397.8 258.84 0.72 0.72 re f 398.52 258.84 73.68 0.72 re f 472.2 258.84 0.72 0.72 re f 472.92 258.84 66.36 0.72 re f 539.28 258.84 0.72 0.72 re f 72 227.52 0.72 31.32 re f 132.96 227.52 0.72 31.32 re f 256.44 227.52 0.72 31.32 re f 330.84 227.52 0.72 31.32 re f 397.8 227.52 0.72 31.32 re f 472.2 227.52 0.72 31.32 re f 539.28 227.52 0.72 31.32 re f q 1 0 0 1 -21.168182 -16.96875 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 104.4482 229.7287 Tm ( )Tj 14.402 0 Td ( )Tj 5.348 0 Td ( )Tj 6.597 0 Td ( )Tj 6.207 0 Td ( )Tj 6.597 0 Td ( )Tj ET Q 72 226.8 0.72 0.72 re f 72.72 226.8 60.24 0.72 re f 132.96 226.8 0.72 0.72 re f 133.68 226.8 122.76 0.72 re f 256.44 226.8 0.72 0.72 re f 257.16 226.8 73.68 0.72 re f 330.84 226.8 0.72 0.72 re f 331.56 226.8 66.24 0.72 re f 397.8 226.8 0.72 0.72 re f 398.52 226.8 73.68 0.72 re f 472.2 226.8 0.72 0.72 re f 472.92 226.8 66.36 0.72 re f 539.28 226.8 0.72 0.72 re f 72 206.88 0.72 19.92 re f 72 206.16 0.72 0.72 re f 72 206.16 0.72 0.72 re f 72.72 206.16 60.24 0.72 re f 132.96 206.88 0.72 19.92 re f 132.96 206.16 0.72 0.72 re f 133.68 206.16 122.76 0.72 re f 256.44 206.88 0.72 19.92 re f 256.44 206.16 0.72 0.72 re f 257.16 206.16 73.68 0.72 re f 330.84 206.88 0.72 19.92 re f 330.84 206.16 0.72 0.72 re f 331.56 206.16 66.24 0.72 re f 397.8 206.88 0.72 19.92 re f 397.8 206.16 0.72 0.72 re f 398.52 206.16 73.68 0.72 re f 472.2 206.88 0.72 19.92 re f 472.2 206.16 0.72 0.72 re f 472.92 206.16 66.36 0.72 re f 539.28 206.88 0.72 19.92 re f 539.28 206.16 0.72 0.72 re f 539.28 206.16 0.72 0.72 re f q 1 0 0 1 -21.168182 -16.96875 cm BT /TT0 1 Tf 3 Tr 9.96 0 0 9.96 96.0482 213.7687 Tm ( )Tj 0.002 Tc 0.001 Tw 7.013 0 Td ( )Tj 19.075 0 Td [( )-2759 ( )]TJ 0 Tc 0 Tw 3.274 0 Td ( )Tj -29.325 -1.157 Td ( )Tj 0.006 Tc -0.003 Tw 11.361 0 Td ( )Tj 0 Tc 0 Tw 15.482 0 Td ( )Tj -26.879 -1.157 Td ( )Tj -0.001 Tc 0.004 Tw 9.409 0 Td ( )Tj 0 Tc 0 Tw 2.036 0 Td ( )Tj 7.037 0 Td ( )Tj 12 0 0 12 134.0882 165.1687 Tm ( )Tj 6.55 0 Td ( )Tj 3.3 -1.16 Td ( )Tj 6.25 0 Td ( )Tj 10.26 0 Td [( )-4860 ( )]TJ -18.75 -1.17 Td ( )Tj ET Q EMC 1 0 0 1 -21.168182 -16.96875 cm BT /Span <>BDC /TT0 1 Tf 12 0 0 12 93.1682 725.5688 Tm [(S)-4 (t)-2 (ud)-10 (y)30 ( 4, )-10 (a)4 ( t)-2 (ot)-2 (a)4 (l)-2 ( of)3 ( 2.9%)3 ( \()-7 (31/)-2 (1056\))3 ( of)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( i)-2 (n t)-2 (he)4 ( T)1 (C)-3 (H)2 ( \()3 (doc)4 (e)4 (t)-12 (a)4 (x)-10 (e)4 (l)-2 (, c)4 (a)4 (r)3 (bo)-10 (pl)-2 (a)4 (t)-2 (i)-2 (n, t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b\) )]TJ 0 -1.16 TD [(a)4 (r)3 (m)-2 ( \()3 (1.5%)3 ( dur)3 (i)-2 (n)-10 (g)10 ( t)-2 (he )-6 (c)4 (he)-6 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( pha)4 (s)-1 (e )-6 (a)4 (nd 1.4)-10 (%)3 ( dur)3 (i)-2 (ng)10 ( t)-2 (h)-10 (e)4 ( m)-2 (onot)-2 (he)4 (r)3 (a)4 (p)-10 (y )10 (pha)4 (s)-11 (e)4 (\))3 ( a)4 (nd 5.7)-10 (% )]TJ 0 -1.17 TD [(\()3 (61/)-2 (1068\))3 ( of)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( i)-2 (n t)-2 (he)4 ( A)2 (C)-3 (-)3 (T)1 (H)2 ( a)-6 (r)3 (m)-2 ( \()3 (1.5%)3 ( du)-10 (r)3 (i)-2 (ng)10 ( t)-2 (he )-6 (c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)-7 (a)4 (p)-20 (y)20 ( p)-10 (ha)4 (s)-1 (e)4 ( a)4 (nd 4.2%)3 ( du)-10 (r)3 (i)-2 (n)-10 (g )]TJ T* [(t)-2 (he)4 ( m)-2 (onot)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( pha)4 (s)]TJ 0.01 Tw 8.83 0 Td [(e)4 (\))3 ( di)-2 (s)-1 (c)4 (ont)-2 (i)-2 (nue)4 (d )]TJ 0 Tw 6.39 0 Td [(t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b )]TJ -0.004 Tc 0.004 Tw [(d)-4 (u)-4 (e t)-6 (o)-4 ( car)-1 (d)-4 (i)-6 (a)-10 (c t)-6 (o)-4 (x)-14 (i)-6 (ci)-6 (t)-16 (y)26 (. )]TJ EMC /P <>BDC 0 Tc 0 Tw -15.22 -1.66 Td [(A)2 (m)-2 (ong)10 ( 64 pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( r)-7 (e)4 (c)-6 (e)4 (i)-2 (vi)-2 (ng)10 ( a)4 (dj)-2 (uva)4 (nt )-12 (c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)-7 (a)4 (p)-10 (y )10 (\()3 (S)-4 (t)-2 (udi)-2 (e)4 (s)-1 ( 1 a)4 (nd 2\))3 ( w)2 (h)-10 (o de)4 (ve)4 (l)-2 (ope)4 (d )]TJ T* [(c)4 (onge)4 (s)-1 (t)-2 (i)-2 (ve)4 ( he)4 (a)-6 (r)3 (t)-2 ( f)3 (a)4 (i)-2 (l)-2 (ur)-7 (e)4 (, )-10 (one )4 (pa)4 (t)-2 (i)-2 (e)4 (nt)-2 ( di)-2 (e)4 (d of)3 ( c)-6 (a)4 (r)3 (di)-2 (o)-10 (m)-12 (y)20 (opa)4 (t)-2 (h)-20 (y)20 (, one)4 ( p)-10 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 ( di)-2 (e)4 (d s)-1 (udde)4 (nl)-22 (y)20 ( w)2 (i)-2 (t)-2 (hout )]TJ T* [(doc)4 (um)-2 (e)4 (nt)-2 (e)4 (d e)4 (t)-2 (i)-2 (ol)-2 (o)-10 (g)-10 (y)20 ( a)4 (nd)-10 ( 3)]TJ 0.002 Tc -0.002 Tw [(3)2 ( p)2 (a)6 (tie)6 (n)2 (ts)1 ( w)4 (e)6 (r)5 (e )-4 (r)5 (e)6 (c)-4 (e)6 (iv)2 (in)2 (g)12 ( c)-4 (a)6 (r)5 (d)2 (ia)-4 (c)6 ( me)6 (d)2 (ic)6 (a)6 (tio)2 (n)2 ( a)6 (t )-9.9 (la)6.1 (s)0.9 (t f)5.1 (o)2 (llo)2 (w)]TJ 0 Tc 0 Tw 34.18 0 Td [(-)3 (up. )]TJ EMC /P <>BDC /C2_0 1 Tf -34.18 -1.16 Td [<0024>2 <005300530055>3 <0052005B>-10 <004C>-2 <0050>-2 <0044>4 <0057>-2 <0048>4 <004F>-12 <005C>30 <000300150017>-10 <0008>3 <000300520049>3 <00030057>-12 <004B0048>4 <00030056>-1 <00580055>3 <0059004C>-2 <0059004C>-2 <0051004A>10 <00030053>-10 <0044>4 <0057>-2 <004C>-2 <0048>4 <00510057>-2 <0056>-1 <0003004B0044>4 <0047>-10 <00030055>3 <0048>4 <0046>4 <005200590048>-6 <0055>-17 <005C>20 <00030057>-2 <005200030044>4 <0003005100520055>3 <0050>-2 <0044>4 <004F0003>-12 <002F>11 <0039>-18 <0028>1 <0029>6 <0003000B>3 <00470048>-6 <0049>3 <004C>-2 <00510048>4 <004700030044>4 <0056>-1 <00030095>-1 <0003001800130008>-7 <000C0003>]TJ EMC /P <>BDC /TT0 1 Tf 0.002 Tc -0.002 Tw T* [(a)6 (n)2 (d)2 ( n)2 (o)2 ( s)-9 (y)22 (mp)2 (to)2 (ms)1 ( o)2 (n)2 ( c)6 (o)2 (n)-8 (tin)2 (u)2 (in)2 (g)12 ( me)6 (d)2 (ic)6 (a)6 (l ma)6 (n)2 (a)-4 (g)2 (e)-4 (me)6 (n)2 (t a)5.9 (t th)2 (e)5.9 ( time)6 ( o)2 (f)5 ( la)6 (s)1 (t f)-5 (o)2 (llo)2 (w)]TJ 0 Tc 0 Tw 31.67 0 Td [(-)3 (up. )-10 (I)23 (n)-10 (c)4 (i)-2 (de)4 (nc)-6 (e)4 ( of )]TJ -31.67 -1.17 Td [(c)4 (onge)4 (s)]TJ 0.002 Tc -0.002 Tw 2.77 0 Td [(tiv)2 (e)6 ( h)2 (e)6 (a)-4 (r)5 (t f)5 (a)6 (ilu)2 (r)-5 (e)6 ( \()]TJ -0.002 Tc 0.002 Tw 7.2 0 Td [(C)-5 (HF)]TJ -0.004 Tc 0.004 Tw 1.94 0 Td [(\))-1 ( i)-6 (s)-5 ( p)-4 (r)-1 (es)-5 (en)-4 (t)-6 (ed)-4 ( i)-6 (n )-4 (T)-3 (ab)-14 (l)-6 (e )]TJ 0 Tc 0 Tw [(1. T)1 (he)4 ( s)-1 (a)4 (f)-7 (e)4 (t)-12 (y)20 ( o)-10 (f)3 ( c)4 (ont)-2 (i)-2 (n)-10 (ua)4 (t)-2 (i)-2 (on or)3 ( r)3 (e)4 (s)-1 (um)-2 (pt)-2 (i)-2 (on )]TJ -0.002 Tc 0.002 Tw -11.91 -1.16 Td [(o)-2 (f)1 ( HE)-1 (R)-5 (Z)-1 (UM)-3 (A )]TJ 0.002 Tc -0.002 Tw [(in)2 ( p)2 (a)6 (tie)6 (n)2 (t)-10 (s)1 ( w)4 (ith )2 (tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ -0.003 Tc 0.003 Tw 17.84 0 Td [(p)-3 (ro)]TJ 0 Tc 0 Tw 1.33 0 Td [(duc)4 (t)-2 (-)3 (i)-2 (nduc)4 (e)4 (d l)-2 (e)-6 (f)3 (t)-2 ( ve)4 (nt)-2 (r)3 (i)-2 (c)4 (ul)-2 (a)-6 (r)3 ( c)4 (a)4 (r)3 (di)-12 (a)4 (c)4 ( d)-20 (y)20 (s)-1 (f)3 (un)-10 (c)4 (t)-2 (i)-2 (on )]TJ -19.17 -1.17 Td [(ha)4 (s)-1 ( not)-2 ( be)4 (e)4 (n s)-1 (t)-2 (udi)-2 (e)4 (d. )]TJ EMC /P <>BDC /TT1 1 Tf 0 -2.17 TD [(T)-3 (ab)-4 (l)-2 (e )4 (1: )]TJ -0.004 Tc 0.004 Tw 6 0 Td [(I)-5 (n)-8 (ci)-6 (d)-8 (en)-8 (ce o)-4 (f)-11 ( C)-2 (o)-4 (n)-8 (g)-4 (es)-5 (t)-1 (i)-6 (v)-4 (e H)-6 (ea)-3.9 (rt )-11 (F)7 (a)-4 (i)-6 (l)-6 (u)-8 (re i)-6 (n)-8 ( A)-2 (d)-8 (j)-1 (u)-8 (v)-4 (a)-4 (n)-8 (t)-1 ( B)-7 (rea)-4 (s)-5 (t)-1 ( C)-2 (a)-4 (n)-8 (ce)-10 (r S)-8 (t)-1 (u)-8 (d)-8 (i)-6 (es )]TJ EMC /TH <>BDC 0.002 Tc -0.002 Tw 11.04 0 0 11.04 381.6405 516.8888 Tm [(In)3.6 (ci)-2.6 (d)14.5 (en)3.7 (ce o)12.9 (f)-2 ( C)6.6 (H)8.3 (F )]TJ EMC /TD <>BDC -0.002 Tc 0 Tw -25.097 -1.761 Td [(St)-6 (udy )]TJ EMC /TD <>BDC 0.002 Tc 8.989 0 Td [(R)6.6 (eg)2 (i)-2.7 (m)9 (en )]TJ EMC /TD <>BDC -0.002 Tc 11.685 0 Td [(T)2 (r)-3.7 (a)-2 (s)-4.3 (t)-5.9 (uz)7.2 (um)-6 (a)-2 (b )]TJ EMC /TD <>BDC 0 Tc 11.848 0 Td [(C)4.6 (on)1.7 (t)-4 (r)-1.6 (ol )]TJ EMC /TD <>BDC /TT0 1 Tf -0.006 Tc 0.006 Tw -33.033 -1.75 Td [(1)-6 ( & 2)]TJ 0 Tc 0 Tw 6.96 0 0 6.96 124.0082 482.0887 Tm (a )Tj EMC /TD <>BDC -0.005 Tc 11.04 0 0 11.04 156.1634 478.1288 Tm (AC)Tj 0 Tc 6.96 0 0 6.96 171.4082 482.0887 Tm (b)Tj /C2_0 1 Tf 11.04 0 0 11.04 174.8882 478.1288 Tm <013A>Tj /TT0 1 Tf 0.002 Tc [(P)3.7 (acl)8.2 (i)-2.6 (t)-2.6 (a)11.2 (x)2 (el)8.2 (+)11.7 (T)-6.6 (r)-2 (a)11.3 (st)-2.6 (u)2 (z)11.3 (u)12.8 (m)19.1 (ab )]TJ EMC /TD <>BDC 0 Tc -0.011 Tw 13.913 0 Td [(3.2%)-4 ( \()-4 (64/)6.3 (2000)10.9 (\))]TJ 0 Tw 6.96 0 0 6.96 397.6082 482.0887 Tm (c )Tj EMC /TD <>BDC -0.011 Tw 11.04 0 0 11.04 447.4068 478.1288 Tm [(1.3%)-4 ( \()-3.9 (21/)6.2 (1655)10.9 (\) )]TJ EMC /TD <>BDC 0 Tw -31.565 -1.761 Td (4 )Tj EMC /TD <>BDC -0.005 Tc 5.13 0 Td (AC)Tj 0 Tc 6.96 0 0 6.96 170.8082 462.6487 Tm (b)Tj /C2_0 1 Tf 11.04 0 0 11.04 174.2882 458.6888 Tm <013A>Tj /TT0 1 Tf 0.002 Tc [(D)6.6 (o)2 (cet)-2.6 (ax)12.9 (el)8.2 (+)11.7 (T)-6.6 (r)-2 (a)11.3 (st)-2.6 (u)2 (z)11.3 (u)12.8 (m)19.1 (ab )]TJ EMC /TD <>BDC 0 Tc 14.478 0 Td [(2%)-4 ( \()7 (20/)-4.7 (1)10.9 (068\) )]TJ EMC /TD <>BDC -0.011 Tw 10.511 0 Td [(0.3%)-4 ( \()-3.9 (3/)-4.7 (1)10.9 (050\) )]TJ EMC /TD <>BDC 0 Tw -31.815 -1.761 Td (4 )Tj EMC /TD <>BDC 4.978 0 Td [(D)4.6 (oc)-1.6 (e)-1.7 (t)-4.6 (a)9.2 (xe)-1.6 (l)6.2 (+)-1.2 (C)4 (a)-1.7 (r)6.9 (bo+)9.7 (T)-8.6 (r)6.9 (a)-1.6 (s)8.5 (t)-4.6 (uz)9.2 (um)17.2 (a)-1.7 (b )]TJ EMC /TD <>BDC -0.011 Tw 16.206 0 Td [(0.4%)-4 ( \()-4 (4/)-4.6 (1)10.9 (056\) )]TJ EMC /TD <>BDC 10.631 0 Td [(0.3%)-4 ( \()-3.9 (3/)-4.7 (1)10.9 (050\) )]TJ EMC /StyleSpan <>BDC 0 Tw 6.48 0 0 6.48 93.1682 427.3687 Tm (a )Tj EMC /P <>BDC -0.001 Tc 0.004 Tw 9.96 0 0 9.96 98.5681 423.8888 Tm [(M)-3.6 (e)-2.8 (d)-7 (ia)-2.8 (n)5 ( f)6.7 (o)-7.1 (llo)-19.1 (w)]TJ 0 Tc 0 Tw 5.928 0 Td (-)Tj /C2_0 1 Tf 0.003 Tc -0.003 Tw 0.337 0 Td [<0058>9 <0053>-3 <00030047>-3 <0058>9 <0055>-1.3 <0044>1.2 <0057>3.9 <004C>3.9 <0052>-15.1 <0051>9.1 <00030049>-1.4 <0052>-3 <0055>-1.4 <00030056>6.5 <0057>3.9 <0058>9 <0047>-3 <004C>3.9 <0048>1.2 <0056>6.5 <00030014>-3 <00030044>1.2 <0051>9 <0047>-3 <00030015>-3 <00030046>1.2 <0052>-3 <0050>21.9 <0045>-3 <004C>-8.1 <0051>9 <0048>1.2 <00470003>-15 <005A>14.1 <0044>1.2 <0056>6.5 <0003001B>-3 <00110016>-3 <0003005C>21.1 <0048>1.3 <0044>1.2 <0055>-1.4 <0056>6.5 <0003004C>-8.2 <0051>9.1 <00030057>3.9 <004B>9 <00480003>-10.8 <0024>2.1 <0026>7.3 <013A>3 <0037>-12.5 <002B>2.2 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(u)12.1 (dde)4.2 (n)12 ( de)4.2 (a)4.2 (t)6.9 (h w)17.1 (i)-5.2 (t)6.9 (h)12.1 (o)-12.1 (u)12 (t)6.9 ( doc)4.2 (um)25 (e)-7.9 (n)12.1 (t)6.8 (e)4.2 (d )]TJ -0.001 Tc 0.001 Tw 39.699 0 Td [(e)-2.8 (tio)-7.1 (lo)-7 (g)-7 (y)5 (.)]TJ /T1_0 1 Tf (\002 )Tj EMC /P <>BDC /TT1 1 Tf 0 Tc 0 Tw 12 0 0 12 93.1682 375.2887 Tm [(T)-3 (ab)-4 (l)-2 (e )4 (2: )]TJ -0.004 Tc 0.004 Tw 6 0 Td [(I)-5 (n)-8 (ci)-6 (d)-8 (en)-8 (ce o)-4 (f)-11 ( C)-2 (a)-4 (rd)-8 (i)-6 (a)-4 (c D)-2 (y)-4 (s)-4.9 (f)-11 (u)1.9 (n)-7.9 (ct)-1 (i)-6 (o)-4 (n)]TJ EMC /StyleSpan <>BDC 0 Tc 0 Tw 8.04 0 0 8.04 336.8882 379.2487 Tm (a )Tj EMC /P <>BDC -0.004 Tc 0.004 Tw 12 0 0 12 343.9682 375.2887 Tm [(i)4 (n)-8 ( Met)-1 (a)-4 (s)-5 (t)-1 (a)-4 (t)-1 (i)-16 (c B)-7 (rea)-4 (s)-5 (t)-1 ( C)-2 (a)-4 (n)-7.9 (c)-10 (er S)-8 (t)-1 (u)-8 (d)-8 (i)-6 (es )]TJ EMC /TH <>BDC 0.002 Tc 0 Tw 11.04 0 0 11.04 396.7735 352.6087 Tm [(In)3.6 (ci)-2.6 (d)14.5 (en)3.7 (ce )]TJ EMC /TD <>BDC -0.005 Tc 0.005 Tw -6.87 -1.75 Td [(NY)-11.3 (H)-9.6 (A 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61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4548 0 obj <> endobj 4549 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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-1.72 Td ( )Tj /TT0 1 Tf 33.75 0 Td ( )Tj /TT3 1 Tf -33.75 -1.72 Td ( )Tj /TT0 1 Tf -0.004 Tc 0.004 Tw 3.81 0 Td ( )Tj 16.97 0 Td ( )Tj 11.28 0 Td ( )Tj /TT2 1 Tf 0 Tc 0 Tw -12.53 -1.17 Td ( )Tj /TT0 1 Tf 15.77 0 Td ( )Tj /TT3 1 Tf -35.3 -1.71 Td ( )Tj /TT0 1 Tf 17.33 0 Td [( )-3570 ( )]TJ 16.15 0 Td ( )Tj -27.51 -1.18 Td [( )-1530 ( )]TJ 14.76 0 Td ( )Tj 12.73 -1.66 Td ( )Tj 0.002 Tc -0.002 Tw -17.74 -1.17 Td ( )Tj EMC /P <>BDC /TT1 1 Tf 0 Tc 0 Tw 0 Tr 14.04 0 0 14.04 94.5558 723.3103 Tm (3 )Tj -0.004 Tc 0.002 Tw 3.846 0 Td [(DO)-3.7 (S)-3.6 (AG)-3.8 (E)-3.7 ( FO)-3.7 (RMS)-3.5 ( AND S)]TJ 0 Tc 0 Tw 11.265 0 Td [(TR)4.1 (EN)4.1 (GTHS )]TJ EMC /P <>BDC /TT0 1 Tf 12 0 0 12 94.5558 702.9103 Tm [(F)6 (or)3 ( i)-2 (nj)-2 (e)4 (c)4 (t)-2 (i)-2 (on:)-2 ( 420 m)-2 (g)10 ( o)-10 (f )-7 (H)2 (E)1 (R)-3 (Z)11 (U)2 (M)-1 (A )-8 (a)4 (s)-1 ( a)4 (n of)-7 (f)3 (-)]TJ 0.002 Tc -0.002 Tw 18.99 0 Td [(w)4 (h)-8 (ite)6 ( to)2 ( p)2 (a)6 (le )-4 (y)22 (e)6 (llo)-8 (w)4 (,)2 ( p)2 (r)5 (e)6 (s)-9 (e)6 (r)-5 (v)2 (a)6 (tiv)2 (e)]TJ 0 Tc 0 Tw 13.53 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.33 0 Td [(f)-1 (r)-11 (ee )]TJ 0 Tc 0 Tw -32.85 -1.17 Td [(l)-12 (y)20 (ophi)-2 (l)-2 (i)-2 (z)-6 (e)4 (d pow)2 (de)4 (r)3 ( i)-2 (n a )-6 (m)-2 (ul)-2 (t)-2 (i)-2 (pl)-2 (e)4 (-)3 (dos)-1 (e)4 ( vi)-2 (a)4 (l)-2 (. )]TJ EMC /Span <>BDC /TT1 1 Tf 14.04 0 0 14.04 94.5558 649.2703 Tm (4 )Tj EMC /Span <>BDC -0.004 Tc 3.846 0 Td [(CO)-3.7 (NT)-3.6 (RAI)-8.2 (NDI)-8.2 (CAT)-3.7 (I)-8.2 (O)-3.7 (NS )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 12 0 0 12 94.5558 628.7503 Tm [(N)2 (one)4 (. )]TJ EMC /P <>BDC /TT1 1 Tf 14.04 0 0 14.04 94.5558 589.1503 Tm (5 )Tj -0.004 Tc 0.002 Tw 3.846 0 Td [(W)-4 (ARNI)-8.2 (NG)-3.7 (S)-3.6 ( AND )-8.4 (PRE)-3.6 (CA)]TJ 0.004 Tw [(UT)-3.6 (I)-8.2 (O)-3.8 (NS )]TJ EMC /Span <>BDC -0.002 Tc 0.002 Tw -3.846 -2 Td [(5)-6.3 (.1 )]TJ EMC /Span <>BDC 0.004 Tc 0 Tw 3.846 0 Td [(C)8.1 (ar)3.5 (d)4.5 (i)8.5 (om)16.5 (yop)13 (at)3.7 (h)13 (y )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 12 0 0 12 94.5558 540.6703 Tm [(T)1 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (s )-1 (c)4 (a)-6 (n c)4 (a)4 (us)-1 (e)4 ( l)-2 (e)-6 (f)3 (t)-2 ( ve)4 (nt)-2 (r)3 (i)-2 (c)4 (ul)-2 (a)4 (r)-7 ( c)-6 (a)4 (r)3 (di)-2 (a)4 (c)4 ( d)-20 (y)20 (s)-1 (f)3 (un)-10 (c)4 (t)-2 (i)-2 (on, a)4 (r)3 (r)3 (h)-20 (y)10 (t)-2 (hm)-2 (i)-2 (a)4 (s)-1 (, h)-10 (y)20 (pe)4 (r)3 (t)-12 (e)4 (ns)-1 (i)-2 (on, )]TJ -0.004 Tc 0.004 Tw 0 -1.17 TD [(d)-4 (i)-6 (s)-5 (ab)-4 (l)-6 (i)-6 (n)-4 (g)6 ( ca)-10 (r)-1 (d)-4 (i)-6 (ac )-10 (f)-1 (ai)-6 (l)-6 (u)-4 (r)-1 (e, )-13.9 (car)-1 (d)-4 (i)-6 (o)-4 (m)-26 (y)16 (o)-4 (p)-4 (at)-6 (h)-24 (y)16 (,)-4 ( an)-4 (d )-14 (car)-11 (d)-4 (i)-6 (ac d)-4 (eat)-6 (h )]TJ /TT2 1 Tf 0.001 Tc -0.001 Tw 24.39 0 Td [([se)-5 (e )]TJ 0 Tc 0.01 Tw 1.92 0 Td [(B)0.9 (ox)-6 (e)4.1 (d W)3 (ar)-1 (ni)-2 (ng)]TJ 0 Tw (: )Tj -26.31 -1.17 Td [(C)-3 (ar)-1 (di)-2 (om)2 (y)4 (opat)-2 (hy)]TJ 0.041 Tc -0.041 Tw 6.7 0 Td (]. )Tj /TT0 1 Tf 0 Tc 0 Tw 0.92 0 Td [(T)1 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (s )]TJ -0.004 Tc 0.004 Tw 9.16 0 Td [(can)-4 ( al)-6 (s)-5 (o )-14 (cau)-4 (s)-5 (e as)-25 (y)16 (m)-6 (p)-4 (t)-6 (o)-4 (m)-6 (at)-6 (i)-5.9 (c d)-13.9 (ecl)-16 (i)-6 (n)-4 (e i)-6 (n)-4 ( l)-6 (ef)-1 (t)-6 ( v)-4 (en)-4 (t)-6 (r)-1 (i)-6 (cu)-4 (l)-6 (ar )]TJ -16.78 -1.17 Td [(ej)-6 (ect)-6 (i)-6 (o)-4 (n)-4 ( f)-1 (r)-11 (act)-6 (i)-6 (o)-4 (n)-4 ( \()-11 (L)7 (V)-2 (E)-13 (F)2.1 (\))-1 (. )]TJ EMC /P <>BDC 0 -1.66 TD [(T)-3 (h)-4 (er)-1 (e i)-6 (s)-5 ( a 4)]TJ 0 Tc 0 Tw 4.68 0 Td [(\2266 )-10 (f)3 (ol)-2 (d i)-2 (nc)4 (r)3 (e)-6 (a)4 (s)-1 (e)4 ( i)-2 (n t)-2 (he)4 ( i)-2 (nc)4 (i)-2 (de)4 (nc)-6 (e)4 ( of)3 ( s)-21 (y)10 (m)-2 (pt)-2 (om)-2 (a)4 (t)-2 (i)-2 (c)4 ( m)-12 (y)20 (oc)4 (a)-6 (r)3 (di)-2 (a)4 (l)-2 ( d)-10 (y)20 (s)-11 (f)3 (un)-10 (c)4 (t)-2 (i)-2 (on a)4 (m)-2 (ong )]TJ 0.002 Tc -0.002 Tw -4.68 -1.17 Td [(p)2 (a)6 (tie)6 (n)2 (ts)1 ( r)5 (e)6 (c)-4 (e)6 (iv)2 (in)2 (g)12 ( tr)-5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 12.47 0 Td [(pr)3 (oduc)4 (t)-2 (s )-1 (a)4 (s)-1 ( a)4 ( s)-1 (i)-2 (n)-10 (g)10 (l)-12 (e)4 ( a)-6 (g)10 (e)4 (nt)-2 ( or)3 ( i)-2 (n c)4 (om)-2 (bi)-2 (na)4 (t)-2 (i)-2 (on)-10 ( t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( c)4 (om)-2 (pa)-6 (r)3 (e)4 (d )]TJ -12.47 -1.16 Td [(w)2 (i)-2 (t)-2 (h t)-2 (hos)-1 (e)4 ( not)-2 ( r)3 (e)4 (c)4 (e)4 (i)-2 (vi)-2 (n)-10 (g)10 ( t)-12 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (s)-1 (. T)1 (he)4 ( hi)-2 (g)10 (h)-10 (e)4 (s)-1 (t)-2 ( a)4 (bs)-1 (ol)-2 (ut)-2 (e)4 ( i)-2 (nc)4 (i)-2 (de)-6 (nc)4 (e)4 ( oc)-6 (c)4 (ur)3 (s)-1 ( w)2 (he)4 (n )-10 (a )]TJ 0 -1.17 TD [(t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t )]TJ 0.002 Tc -0.002 Tw 8.44 0 Td [(is)1 ( a)6 (d)2 (min)2 (is)1 (te)6 (r)5 (e)6 (d)2 ( w)4 (ith)2 ( a)6 (n)2 ( a)6 (n)2 (th)-8 (r)5 (a)6 (c)-14 (y)22 (c)6 (lin)2 (e)6 (. )]TJ EMC /P <>BDC 0 Tw -8.44 -1.67 Td [(W)-4 (it)]TJ /C2_0 1 Tf 0 Tc [<004B004B0052004F>-2 <00470003002B>2 <0028>1 <0035>-3 <003D>11 <0038>2 <0030>-1 <0024>2 <00030049>3 <0052>-10 <0055>3 <00030095>-1 <0003001400190008>3 <00030044>4 <00450056>-1 <0052004F>-2 <00580057>-2 <0048>4 <000300470048>-6 <0046>4 <0055>3 <0048>-6 <0044>4 <0056>-11 <0048>4 <0003004C>-2 <00510003>-10 <002F>21 <0039>-8 <0028>1 <00290003>-4 <0049>3 <0055>3 <00520050>-2 <000300530055>3 <0048>]TJ /TT0 1 Tf 28.05 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.33 0 Td [(t)-6 (r)-1 (eat)-16 (m)-6 (en)-4 (t)-6 ( v)-4 (al)-6 (u)-4 (es)-5 ( o)-4 (r)-1 ( an )]TJ /C2_0 1 Tf 0 Tc 0 Tw -28.38 -1.16 Td [<002F>11 <0039>2 <0028>-9 <0029>6 <000300590044>4 <004F>-2 <0058>-10 <0048>4 <000300450048>4 <004F>-2 <0052005A>2 <0003004C>-2 <00510056>-1 <0057>-2 <004C>-2 <0057>-2 <00580057>-2 <004C>-2 <005200510044>4 <004F>-2 <0003004F>-2 <004C>-2 <0050>-2 <004C>-2 <0057>-2 <0056>-1 <000300520049>3 <0003005100520055>3 <0050>-2 <0044>4 <004F>-2 <00030044>4 <0051004700030095>-1 <0003001400130008>3 <00030044>4 <00450056>-1 <0052004F>-2 <00580057>-2 <0048>4 <000300470048>4 <0046>-6 <0055>3 <0048>-6 <0044>4 <0056>-1 <0048>4 <0003004C>-2 <00510003>-10 <002F>11 <0039>2 <0028>-9 <0029>6 <00030049>3 <0055>3 <005200500003>]TJ EMC /P <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw T* [(p)-4 (r)-1 (et)-6 (r)-1 (e)-10 (at)-6 (m)-6 (en)-4 (t)-6 ( v)-4 (al)-6 (u)-4 (es )]TJ /TT2 1 Tf 0 Tc 0 Tw 8.1 0 Td [([)-1 (s)-1 (e)4 (e )-6 (D)2 (os)-1 (age)4 ( and A)1 (dm)2 (i)-2 (ni)-2 (s)-1 (t)-2 (r)-1 (at)-2 (i)-2 (on \()13 (2.3)]TJ -0.023 Tc 0.023 Tw 14.81 0 Td (\)])Tj /TT0 1 Tf 0 Tc 0 Tw 0.74 0 Td [(. T)1 (he)4 ( s)-1 (a)4 (f)3 (e)4 (t)-12 (y)20 ( of )-7 (c)-6 (ont)-2 (i)-2 (nua)4 (t)-2 (i)-2 (on )]TJ -0.003 Tc 0.003 Tw [(o)-3 (r )]TJ 0 Tc 0 Tw -23.65 -1.17 Td [(r)3 (e)4 (s)-1 (um)-2 (pt)-2 (i)-2 (on of)3 ( H)2 (E)1 (R)-3 (Z)1 (U)2 (M)-11 (A)2 ( i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)4 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (-)3 (i)-2 (nduc)-6 (e)4 (d l)-2 (e)-6 (f)3 (t)-2 ( ve)4 (nt)-2 (r)3 (i)-2 (c)4 (ul)-2 (a)4 (r )-7 (c)4 (a)4 (r)3 (di)-2 (a)-6 (c )]TJ T* [(d)-10 (y)20 (s)-1 (f)3 (un)-10 (c)4 (t)-2 (i)-2 (on ha)4 (s)-1 ( not)-2 ( be)4 (e)4 (n )-10 (s)-1 (t)-2 (udi)-2 (e)4 (d. )]TJ EMC /P <>BDC -0.004 Tc 0.004 Tw 0 -1.66 TD [(P)-8 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( w)-2 (h)-4 (o)-4 ( r)-1 (ecei)-6 (v)-14 (e an)-4 (t)-16 (h)-3.9 (r)-1 (ac)-20.1 (y)16.1 (cl)-6 (i)-6 (n)-4 (e )-10 (af)-1 (t)-6 (e)-10 (r)-1 ( s)-5 (t)-6 (o)-4 (p)-4 (p)-4 (i)-6 (n)-4 (g )-4 (H)-2 (E)]TJ -0.011 Tc 0.011 Tw 21.27 0 Td [(R)-14 (ZU)-9 (M)-12 (A )]TJ -0.004 Tc 0.004 Tw 3.85 0 Td [(m)-16 (a)-20 (y)16 ( al)-6 (s)-5 (o)-4 ( b)-4 (e )-10 (at)-6 ( i)-6 (n)-4 (cr)-1 (eas)-15 (ed)-4 ( r)-0.9 (i)-6.1 (s)-4.9 (k)-4 ( o)-4 (f )]TJ 0 Tc 0 Tw -25.12 -1.17 Td [(c)4 (a)4 (r)3 (di)-2 (a)-6 (c)4 ( d)-20 (y)20 (s)-1 (f)3 (unc)4 (t)-2 (i)-2 (on )]TJ /TT2 1 Tf -0.004 Tc 0.004 Tw [([)-5 (s)-5 (ee )]TJ 0 Tc 0 Tw 10.02 0 Td [(D)2 (r)-1 (ug I)3 (nt)-2 (e)4 (r)-1 (ac)4 (t)-2 (i)-2 (ons )-11 (\()13 (7)-10 (\) )]TJ /TT0 1 Tf -0.004 Tc 0.004 Tw 8.85 0 Td [(an)-14 (d )]TJ /TT2 1 Tf 0 Tc 0 Tw 1.7 0 Td [(C)-3 (l)-2 (i)-2 (ni)-2 (c)4 (al)-2 ( P)1 (har)-1 (m)2 (ac)4 (ol)-2 (ogy)4 ( \()13 (12.3)-10 (\))]TJ 0.041 Tc -0.041 Tw 12 0 Td (]. )Tj EMC /P <>BDC 0 Tc 0 Tw -32.57 -1.67 Td [(C)-3 (ar)-1 (di)-2 (ac)4 ( M)3 (oni)-2 (t)-2 (or)-1 (i)-2 (ng )]TJ EMC /P <>BDC /TT0 1 Tf T* [(C)-3 (onduc)4 (t)-2 ( t)-2 (hor)3 (oug)10 (h c)-6 (a)4 (r)3 (di)-2 (a)-6 (c)4 ( a)4 (s)-1 (s)-1 (e)4 (s)-1 (s)-1 (m)-2 (e)4 (nt)-2 (, i)-2 (nc)4 (l)-2 (udi)-2 (n)-10 (g)10 ( h)-10 (i)-2 (s)-1 (t)-2 (or)-7 (y)20 (, ph)-20 (y)20 (s)-1 (i)-2 (c)4 (a)4 (l)-2 ( e)4 (x)-10 (a)4 (m)-2 (i)-2 (na)4 (t)-12 (i)-2 (on, a)4 (nd )]TJ 0 -1.17 TD [(de)4 (t)-2 (e)4 (r)3 (m)-2 (i)-2 (na)4 (t)-2 (i)-2 (on of )-7 (L)11 (V)2 (E)-9 (F)6 ( b)-10 (y )10 (e)-6 (c)4 (hoc)-6 (a)4 (r)3 (di)-2 (o)-10 (g)10 (r)3 (a)4 (m)-2 ( or)3 ( M)-11 (U)-8 (G)2 (A)2 ( s)-1 (c)4 (a)4 (n. T)1 (h)-10 (e)4 ( f)3 (ol)-2 (l)-2 (o)]TJ -0.004 Tc 0.004 Tw [(w)-2 (i)-6 (n)-14 (g )-4 (s)-5 (ch)-4 (ed)-4 (u)-4 (l)-6 (e i)-6 (s )]TJ 0 Tw T* [(r)-1 (eco)-4 (m)-6 (m)-6 (en)-4 (d)-4 (ed)-4 (: )]TJ EMC /Lbl <>BDC /C2_1 1 Tf 0 Tc 3 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 0.002 Tc -0.002 Tw 1.5 0 Td [(B)9 (a)6 (s)1 (e)6 (lin)2 (e )-4 (L)13 (V)-6 (E)3 (F)8 ( m)-10 (e)6 (a)6 (s)1 (u)2 (r)-5 (e)-4 (me)6 (n)2 (t imme)6 (d)2 (ia)6 (te)6 (l)-10 (y)22 ( p)2 (r)5 (io)2 (r)5 ( t)-10 (o)2 ( in)2.1 (itia)6 (tio)2 (n)2 ( o)2 (f)5 ( H)4 (E)3 (R)-1 (Z)13 (U)4 (M)-9 (A )]TJ EMC /Lbl <>BDC /C2_1 1 Tf 0 Tc 0 Tw -1.5 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(L)11 (V)2 (E)-9 (F)6 ( m)-2 (e)-6 (a)4 (s)-1 (ur)3 (e)4 (m)-2 (e)4 (nt)-2 (s)-1 ( e)4 (v)-10 (e)-6 (r)-7 (y)20 ( 3 m)-2 (ont)-2 (hs)-1 ( dur)3 (i)-2 (n)-10 (g)10 ( a)4 (nd u)-10 (pon c)4 (om)-2 (pl)-2 (e)4 (t)-2 (i)-2 (on of)3 ( H)2 (E)1 (R)-3 (Z)1 (U)2 (M)-1 (A )]TJ EMC /Lbl <>BDC /C2_1 1 Tf -1.5 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 1.5 0 Td [(R)-7 (ep)-4 (eat )-16 (L)7 (V)-2 (E)-13 (F)2 ( m)-6 (eas)-5 (u)-4 (r)-11 (em)-15.9 (en)-4.1 (t)-5.9 ( at)-6 ( 4)-4 ( w)-2.1 (eek)-4 ( i)-6 (n)-4 (t)-6 (e)-10 (r)-1 (v)-4 (al)-6 (s)-5 ( i)-6 (f )-11 (H)-2 (E)-3 (R)-7 (Z)7 (U)-2 (M)-5 (A)-2 ( i)-6 (s)-5 ( w)-2 (i)-6 (t)-6 (h)-4 (h)-4 (el)-6 (d)-4 ( f)-11 (o)-4 (r )]TJ 0.002 Tc -0.002 Tw T* [(s)1 (ig)12 (n)2 (if)5 (ic)6 (a)6 (n)2 (t l)]TJ -0.004 Tc 0.004 Tw [(e)-10 (f)-1 (t)-6 ( v)-4 (en)-4 (t)-6 (r)-1 (i)-6 (cu)-4 (l)-6 (a)-10 (r)-1 ( car)-1 (d)-4 (i)-16 (ac d)-23.9 (y)15.9 (s)-5 (f)-1 (u)-4 (n)-13.9 (ct)-6 (i)-6 (o)-4 (n )]TJ /TT2 1 Tf 0 Tc 0 Tw 18.74 0 Td [([)-1 (s)-1 (e)4 (e)4 ( D)2 (os)-1 (age)4 ( and A)1 (dm)2 (i)-2 (ni)-2 (s)-1 (t)-2 (r)-1 (at)-2 (i)-2 (on \()13 (2.3)]TJ -0.033 Tc 0.033 Tw 14.8 0 Td (\)] )Tj EMC /Lbl <>BDC /C2_1 1 Tf 0 Tc 0 Tw -35.04 -1.71 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(L)11 (V)2 (E)-9 (F)6 ( m)-2 (e)-6 (a)4 (s)-1 (ur)3 (e)4 (m)-2 (e)4 (nt)-2 (s)-1 ( e)4 (v)-10 (e)-6 (r)-7 (y)20 ( 6 m)-2 (ont)-2 (hs)-1 ( f)3 (or )-7 (a)4 (t)-2 ( l)-2 (e)4 (a)4 (s)-1 (t)-2 ( 2 )-20 (y)20 (e)-6 (a)4 (r)3 (s)-1 ( f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (n)-10 (g)10 ( c)4 (om)-2 (pl)-2 (e)4 (t)-12 (i)-2 (on of )]TJ 0 -1.18 TD [(H)2 (E)1 (R)-3 (Z)11 (U)2 (M)-1 (A )-8 (a)4 (s)-1 ( a )-6 (c)4 (om)-2 (pone)4 (nt)-2 ( of)3 ( a)4 (dj)-2 (uva)4 (nt)-2 ( t)-2 (he)4 (r)-7 (a)4 (p)-20 (y)20 (. )]TJ EMC /Span <>BDC -4.5 -1.66 Td [(I)13 (n S)-4 (t)-2 (ud)-20 (y)20 ( 1, 15%)3 ( \()3 (158/)-2 (10)-10 (31\))3 ( of)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( di)-2 (s)-1 (c)4 (ont)-2 (i)-2 (nue)4 (d t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b due)4 ( t)-2 (o c)4 (l)-2 (i)-2 (ni)-2 (c)4 (a)4 (l)-2 ( e)4 (vi)-2 (de)4 (nc)-6 (e)4 ( of )]TJ 0.002 Tc -0.002 Tw 0 -1.17 TD [(m)-10 (y)22 (o)2 (c)-4 (a)6 (r)5 (d)2 (ia)6 (l d)-18 (y)22 (s)1 (f)5 (u)2 (n)2 (c)6 (tio)2 (n)2 ( o)-8 (r)5 ( s)1 (ig)12 (n)2 (if)5 (ic)-4 (a)6 (n)2 (t d)2 (e)6 (c)6 (lin)2 (e)6 ( in )-8 (L)2.9 (V)4 (E)3.1 (F)8 ( a)-4 (f)5 (te)5.9 (r)5 ( a)6 ( m)-10 (e)6 (d)2 (ia)6 (n)2 ( f)5 (o)2 (llo)-8 (w)]TJ 0 Tc 0 Tw 30.77 0 Td [(-)3 (up dur)3 (a)4 (t)-2 (i)-2 (on of)3 ( 8.7 )]TJ -30.77 -1.16 Td [(y)20 (e)-6 (a)-6 (r)3 (s)-1 ( i)-2 (n t)-2 (he)4 ( A)2 (C)-3 (-)3 (T)-9 (H)2 ( \()3 (a)4 (nt)-2 (h)-10 (r)3 (a)4 (c)-16 (y)20 (c)4 (l)-2 (i)-2 (ne)4 (, )-10 (c)-16 (y)20 (c)4 (l)-2 (ophos)-1 (pha)-6 (m)-2 (i)-2 (de)4 (, pa)4 (c)4 (l)-2 (i)-2 (t)-2 (a)4 (x)-10 (e)4 (l)-2 (, a)4 (nd t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b\))3 ( a)4 (r)3 (m)-2 (. )-10 (I)23 (n )]TJ EMC /Artifact <>BDC 19.25 -3.75 Td (6)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 32.5558 26.3903 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4552 0 obj <>>>/Resources 4510 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4553 0 obj <> endobj 4554 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
 endstream endobj 4555 0 obj <> endobj 4556 0 obj <>stream q 1 0 0 1 21.398712 16.390259 cm 0 0 612 792 re W n /Artifact <>BDC q 1 0 0 1 -21.398712 -16.390259 cm BT /CS0 cs 0 scn /TT0 1 Tf 3 Tr 12 0 0 12 93.3987 55.0303 Tm ( )Tj 19.75 0 Td ( )Tj 19.25 0 Td ( )Tj /TT1 1 Tf 14.04 0 0 14.04 110.9206 723.3103 Tm ( )Tj 16.06 0 Td ( )Tj /TT0 1 Tf 12 0 0 12 559.1187 702.9103 Tm ( )Tj -34.51 -2.33 Td ( )Tj 1.48 -1.67 Td ( )Tj 7.4 -1.66 Td ( )Tj 11.2 0 Td ( )Tj 9.86 0 Td ( )Tj -15.59 -1.17 Td ( )Tj -2.68 -1.17 Td ( )Tj 0.002 Tc -0.002 Tw 22.63 -1.16 Td ( )Tj 0 Tc 0 Tw -37.44 -1.17 Td ( )Tj 27.47 0 Td ( )Tj -27.11 -1.67 Td ( )Tj -0.01 Tw 4.79 0 Td ( )Tj 0 Tw 7.09 0 Td ( )Tj 7.11 0 Td [( )-1220 ( )-3870 ( )]TJ 11.29 0 Td [( )-2250 ( )]TJ /TT2 1 Tf -28.34 -1.72 Td ( )Tj /TT0 1 Tf 0.002 Tc -0.002 Tw 21.09 0 Td ( )Tj 14 0 Td ( )Tj 0 Tc 0 Tw -26.4 -1.17 Td ( )Tj 25.15 0 Td ( )Tj -16.99 -1.16 Td ( )Tj 0.41 -1.17 Td ( )Tj /TT2 1 Tf -17.26 -1.73 Td ( )Tj /TT0 1 Tf 0.002 Tc -0.002 Tw 17.68 0 Td ( )Tj 0 Tc 0 Tw 8.17 0 Td ( )Tj /TT2 1 Tf -25.85 -1.71 Td ( )Tj /TT0 1 Tf 19.98 -1.17 Td ( )Tj /TT2 1 Tf -19.98 -1.72 Td ( )Tj /TT0 1 Tf -0.004 Tc 0.004 Tw 7.17 0 Td ( )Tj 0 Tc 0 Tw 3.69 0 Td ( )Tj 24.42 -1.17 Td ( )Tj -24.81 -1.16 Td ( )Tj 22.62 0 Td ( )Tj -0.004 Tc 0.004 Tw -25.01 -1.17 Td ( )Tj 0 Tc 0 Tw 17.2 0 Td [( )-2980 ( )]TJ /TT2 1 Tf -25.28 -1.72 Td ( )Tj ET Q /CS0 cs 0 scn 126 339.36 381.12 0.599 re f q 1 0 0 1 -21.398712 -16.390259 cm BT /TT0 1 Tf 3 Tr 12 0 0 12 554.5587 343.6304 Tm ( )Tj ET Q 330.96 325.32 202.2 0.599 re f q 1 0 0 1 -21.398712 -16.390259 cm BT /TT0 1 Tf 3 Tr 12 0 0 12 388.7187 329.5903 Tm ( )Tj /TT1 1 Tf -0.004 Tc 0.004 Tw 9.63 0 Td ( )Tj /TT0 1 Tf 0 Tc 0 Tw 4.7 0 Td ( )Tj /TT3 1 Tf -35.61 -1.67 Td ( )Tj /TT2 1 Tf 0.13 -1.71 Td ( )Tj /TT0 1 Tf -0.004 Tc 0.004 Tw 11 0 Td ( )Tj 6.28 0 Td ( )Tj /TT3 1 Tf 0 Tc 0 Tw 1.91 0 Td ( )Tj /TT0 1 Tf 7.61 -2.34 Td ( )Tj 7.86 0 Td ( )Tj -23.35 -1.16 Td ( )Tj /TT1 1 Tf -0.002 Tc 0.002 Tw 20.94 0 Td ( )Tj 0 Tc 0 Tw -25.68 -1.17 Td ( )Tj /TT2 1 Tf -6.57 -1.73 Td ( )Tj /TT0 1 Tf 12.36 0 Td [( )-4930 ( )]TJ /TT2 1 Tf -12.36 -1.71 Td ( )Tj /TT0 1 Tf 35.19 0 Td ( )Tj -32.33 -1.17 Td ( )Tj 13.93 0 Td ( )Tj -8.09 -1.17 Td ( )Tj 21.9 0 Td ( )Tj ET Q EMC 1 0 0 1 -21.398712 -16.390259 cm BT /Span <>BDC /TT1 1 Tf -0.002 Tc 14.04 0 0 14.04 93.3987 723.3103 Tm [(2)-6.3 (.4 )]TJ EMC /Span <>BDC 0.004 Tc -0.006 Tw 3.846 0 Td [(P)8.2 (r)3.5 (e)3.6 (p)4.4 (ar)12.1 (at)12.2 (ion)4.5 ( f)12.2 (or)3.6 ( A)8.1 (d)13 (m)16.5 (in)4.5 (ist)3.7 (r)12.1 (at)3.7 (i)8.5 (on )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw 12 0 0 12 93.3987 702.9103 Tm [(T)1 (o pr)3 (e)4 (ve)4 (nt)-2 ( m)-2 (e)4 (di)-2 (c)-6 (a)4 (t)-2 (i)-2 (on e)4 (r)-7 (r)3 (or)3 (s)-1 (, i)-2 (t)-2 ( i)-2 (s)-1 ( i)-2 (m)-2 (por)3 (t)-2 (a)4 (nt)-2 ( t)-2 (o c)4 (he)4 (c)4 (k t)-2 (he)4 ( vi)-2 (a)4 (l)-2 ( l)-2 (a)4 (be)4 (l)-2 (s)-1 ( t)-2 (o e)4 (ns)-11 (ur)3 (e)4 ( t)-2 (ha)4 (t)-2 ( t)-2 (he)4 ( dr)3 (u)-10 (g)10 ( b)-10 (e)4 (i)-2 (ng )]TJ 0 -1.16 TD [(pr)3 (e)4 (pa)4 (r)-7 (e)4 (d a)4 (nd )-10 (a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)-6 (d i)-2 (s)-1 ( H)2 (E)1 (R)-3 (Z)11 (U)2 (M)-1 (A)2 ( \()3 (t)-12 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b-)3 (pkr)3 (b\))3 ( a)-6 (nd not)-2 ( a)4 (do-)-7 (t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b )]TJ -0.004 Tc 0 -1.17 TD [(em)-6 (t)-6 (an)-4 (s)-5 (i)-6 (n)-4 (e. )]TJ EMC /P <>BDC /TT3 1 Tf 0.002 Tc 0 -1.67 TD [(R)3 (e)6 (c)6 (o)2 (n)2 (s)1 (titu)2 (tio)2 (n )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 -1.66 TD [(R)-3 (e)4 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (e)4 ( e)4 (a)4 (c)4 (h 420 m)-12 (g)10 ( vi)-2 (a)4 (l)-2 ( of )-7 (H)2 (E)1 (R)-3 (Z)1 (U)2 (M)-1 (A)2 ( w)2 (i)-2 (t)-12 (h 20 m)-12 (L)21 ( of )-7 (B)7 (a)-6 (c)4 (t)-2 (e)4 (r)3 (i)-2 (os)-1 (t)-2 (a)4 (t)-2 (i)-2 (c)-6 ( W)-6 (a)4 (t)-2 (e)4 (r)3 ( f)3 (or )-7 (I)13 (nj)-2 (e)-6 (c)4 (t)-2 (i)-2 (on )]TJ 0 -1.17 TD [(\()3 (B)7 (W)-6 (F)-4 (I)13 (\))-7 (, U)2 (S)-4 (P)-4 (, c)4 (ont)-2 (a)4 (i)-2 (ni)-2 (ng 1.1%)3 ( be)4 (nz)-16 (y)20 (l)-2 ( a)4 (l)-2 (c)4 (ohol )-12 (a)4 (s)-1 ( a)-6 ( pr)3 (e)4 (s)-1 (e)4 (r)3 (v)-10 (a)4 (t)-2 (i)-2 (ve)4 ( t)-2 (o )-10 (y)20 (i)-12 (e)4 (l)-2 (d a)4 ( m)-12 (ul)-2 (t)-2 (i)-2 (pl)-2 (e)4 (-)3 (dos)-1 (e)4 ( s)-1 (ol)-2 (ut)-2 (i)-2 (on )]TJ T* [(c)4 (ont)-2 (a)4 (i)-2 (ni)-2 (ng)10 ( 21 m)-12 (g)10 (/)-2 (m)-12 (L)11 ( t)-2 (r)3 (a)-6 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b-)3 (pkr)3 (b t)-2 (ha)4 (t)-2 ( de)4 (l)-2 (i)-2 (ve)4 (r)3 (s)-1 ( 20 m)-12 (L)11 ( \()3 (420 m)-12 (g)10 ( t)-2 (r)3 (a)4 (s)-1 (t)]TJ -0.004 Tc 0.004 Tw 29.6 0 Td [(u)-14 (z)-10 (u)-4 (m)-6 (ab)]TJ 0 Tc 0 Tw 3.18 0 Td [(-)3 (pkr)3 (b)]TJ 0.01 Tw [(\))3 (. I)13 (n )]TJ 0.002 Tc -0.002 Tw -32.78 -1.16 Td [(p)2 (a)6 (tie)6 (n)2 (ts)1 ( w)4 (ith)2 ( k)2 (n)2 (o)2 (w)4 (n)2 ( h)-8 (y)22 (p)-8 (e)6 (r)5 (s)1 (e)6 (n)2 (s)1 (itiv)2 (it)-10 (y)22 ( to)2 ( b)2 (e)6 (n)2 (z)-14 (y)22 (l )-10 (a)6 (lc)6 (o)2 (h)2 (o)2 (l,)2 ( r)5 (e)5.9 (c)6 (o)2 (n)2 (s)1 (titu)2 (te)6 ( w)4 (ith)2 ( 2)-8 (0)2 ( m)-10 (L)23 ( o)2 (f)5 ( S)-2 (te)6 (r)5 (ile)6 ( W)-4 (a)6 (te)-4 (r )]TJ 0 Tc 0 Tw T* [(f)3 (or )-7 (I)13 (nj)-2 (e)4 (c)4 (t)-2 (i)-2 (on \()3 (S)-4 (W)-6 (F)-4 (I)13 (\))-7 ( w)2 (i)-2 (t)-2 (hout)-2 ( pr)3 (e)4 (s)-1 (e)4 (r)3 (va)4 (t)-2 (i)-2 (ve)4 ( t)-2 (o )-20 (y)20 (i)-2 (e)4 (l)-2 (d)-10 ( a)4 ( s)-1 (i)-2 (ng)10 (l)-2 (e)4 ( us)-11 (e)4 ( s)-1 (ol)-2 (ut)-2 (i)-2 (on. )]TJ EMC /P <>BDC -0.012 Tc 0.012 Tw 0 -1.67 TD [(Us)-3 (e )]TJ 0 Tc -0.01 Tw 1.78 0 Td [(a)4 (ppr)3 (opr)3 (i)-2 (a)14 (t)-2 (e )-6 (a)14 (s)-1 (e)4 (p)10 (t)8 (i)-2 (c)4 ( t)8 (e)4 (c)4 (hn)10 (i)-2 (que )]TJ 0 Tw 11.87 0 Td [(w)2 (he)4 (n )]TJ -0.003 Tc 0.003 Tw [(p)-3 (e)1 (rfo)7 (rm)5 (i)-5 (n)6.9 (g )]TJ 0 Tc 0 Tw 7.11 0 Td [(t)-2 (he )4 (f)3 (ol)-2 (l)-2 (ow)12 (i)-2 (ng )]TJ -0.004 Tc 0.004 Tw 5.59 0 Td [(r)-1 (eco)]TJ 0.002 Tc -0.002 Tw 1.7 0 Td [(n)2 (s)11 (ti)10 (tu)12 (ti)10 (o)2 (n )]TJ -0.014 Tc 0.014 Tw 4 0 Td [(s)-15 (t)-16 (ep)-14 (s)-5 (: )]TJ EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 0 Tw -29.05 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 0.002 Tc -0.002 Tw 1.5 0 Td [(U)4 (s)1 (in)2 (g)12 ( a)6 ( s)1 (te)-4 (r)5 (ile)6 ( s)-19 (y)22 (r)5 (in)-8 (g)12 (e)6 (,)2 ( s)1 (l)-10 (o)2 (w)4 (l)-10 (y)22 ( in)2 (je)6 (c)6 (t th)2 (e)6 ( 2)2 (0)2 ( m)-10 (L)13 ( o)-8 (f )-5 (d)2 (ilu)2.1 (e)6 (n)2 (t in)2 (to)2 ( th)2 (e)6 ( v)2 (ia)6 (l c)6 (o)2 (n)2 (ta)6 (in)2 (in)2 (g)12 ( th)2 (e )]TJ 0 Tc 0 Tw 0 -1.17 TD [(l)-12 (y)20 (ophi)-2 (l)-2 (i)-2 (z)-6 (e)4 (d c)4 (a)4 (ke)4 ( of )-7 (H)2 (E)1 (R)-3 (Z)11 (U)2 (M)-1 (A)2 (. )-10 (T)1 (he)4 ( s)-1 (t)-2 (r)3 (e)-6 (a)4 (m)-2 ( of)3 ( di)-12 (l)-2 (ue)4 (nt)-2 ( s)-1 (houl)-2 (d be)4 ( di)-2 (r)3 (e)4 (c)4 (t)-2 (e)4 (d i)-12 (nt)-2 (o t)-2 (he )]TJ 0 -1.16 TD [(l)-12 (y)20 (ophi)-2 (l)-2 (i)-2 (z)-6 (e)4 (d c)4 (a)4 (ke)4 (. T)1 (h)-10 (e)4 ( r)3 (e)-6 (c)-6 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (e)4 (d vi)-2 (a)4 (l )-12 (y)30 (i)-12 (e)4 (l)-2 (ds)-1 ( a)4 ( s)-1 (o)-10 (l)-2 (ut)-2 (i)-2 (on f)3 (or)3 ( m)-2 (ul)-2 (t)-2 (i)-2 (pl)-2 (e)4 (-)3 (dos)-1 (e)4 ( us)-1 (e)4 (, )]TJ 0 -1.17 TD [(c)4 (ont)-2 (a)4 (i)-2 (ni)-2 (ng)10 ( 21 m)-12 (g)10 (/)-2 (m)-12 (L)11 ( t)-2 (r)3 (a)-6 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b-)3 (pkr)3 (b. )]TJ EMC /Lbl <>BDC /C2_0 1 Tf -1.5 -1.73 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 0.002 Tc -0.002 Tw 1.5 0 Td [(S)-2 (w)4 (ir)5 (l th)2 (e)6 ( v)2 (ia)6 (l g)12 (e)6 (n)2 (tl)-20 (y)22 ( to)2 ( a)6 (i)-10 (d)2 ( r)5 (e)6 (c)6 (o)2 (n)2 (s)1 (titu)2 (tio)2 (n)2 (. )]TJ /TT1 1 Tf -0.002 Tc 0.002 Tw 16.89 0 Td [(DO)-4 ( NO)-4 (T)-5 ( S)-6 (H)-4 (AK)6 (E)-5 (. )]TJ EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 0 Tw -18.39 -1.71 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(S)-4 (l)-2 (i)-2 (g)10 (ht)-2 ( f)3 (oa)4 (m)-2 (i)-2 (ng)10 ( o)-10 (f)3 ( t)-2 (he)4 ( pr)3 (o)-10 (duc)4 (t)-2 ( m)-2 (a)-6 (y)20 ( b)-10 (e)4 ( pr)3 (e)4 (s)-11 (e)4 (nt)-2 ( upo)-10 (n r)3 (e)4 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (i)-2 (on. A)2 (l)-2 (l)-2 (ow)2 ( t)-2 (he)4 ( vi)-2 (a)4 (l)-2 ( t)-2 (o )]TJ T* [(s)-1 (t)-2 (a)4 (nd undi)-2 (s)-1 (t)-2 (ur)3 (be)4 (d f)3 (or)3 ( a)4 (pp)-10 (r)3 (ox)-10 (i)-2 (m)-2 (a)4 (t)-2 (e)4 (l)-12 (y)30 ( 5 m)-2 (i)-2 (nut)-2 (e)4 (s)-1 (. )]TJ EMC /Lbl <>BDC /C2_0 1 Tf -1.5 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 1.5 0 Td [(P)-8 (ar)-1 (en)-4 (t)-6 (er)-11 (al)-6 ( d)-4 (r)-1 (u)-14 (g )]TJ 0 Tc 0 Tw 6.38 0 Td [(pr)3 (oduc)4 (t)-2 (s )-11 (s)-1 (houl)-2 (d be)4 ( i)-2 (ns)-1 (pe)4 (c)4 (t)-2 (e)4 (d vi)-2 (s)-1 (ua)4 (l)-2 (l)-12 (y)20 ( f)3 (o)-10 (r)3 ( pa)4 (r)3 (t)-2 (i)-2 (c)4 (ul)-2 (a)4 (t)-12 (e)4 ( m)-2 (a)4 (t)-2 (t)-2 (e)4 (r)-7 ( a)4 (nd )]TJ -6.38 -1.17 Td [(di)-2 (s)-1 (c)4 (ol)-2 (or)3 (a)4 (t)-2 (i)-2 (on pr)3 (i)-2 (or)3 ( t)-2 (o a)4 (d)-10 (m)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (r)3 (a)4 (t)-2 (i)-2 (on, w)2 (he)4 (ne)4 (ve)4 (r)3 ( s)-11 (ol)-2 (ut)-2 (i)-2 (on a)4 (nd c)4 (ont)-2 (a)4 (i)-2 (ne)4 (r)3 ( pe)-6 (r)-7 (m)-2 (i)-2 (t)-2 (. )-10 (I)23 (ns)-1 (pe)4 (c)4 (t )]TJ 0 -1.16 TD [(vi)-2 (s)-1 (ua)4 (l)-2 (l)-12 (y)20 ( f)3 (or)3 ( p)-10 (a)4 (r)3 (t)-2 (i)-2 (c)4 (ul)-2 (a)4 (t)-2 (e)4 (s )-11 (a)-6 (nd di)-2 (s)-1 (c)4 (ol)-2 (or)3 (a)4 (t)-2 (i)-2 (on. T)1 (he)4 ( s)-1 (ol)-2 (ut)-2 (i)-2 (on s)-1 (houl)-2 (d be)4 ( f)3 (r)3 (e)4 (e)4 ( of)3 ( vi)-12 (s)-1 (i)-2 (bl)-2 (e )]TJ -0.004 Tc 0.004 Tw 0 -1.17 TD [(p)-4 (ar)-1 (t)-6 (i)-6 (cu)-4 (l)-6 (at)-6 (es)-5 (,)-4 ( cl)-6 (e)-10 (ar )]TJ 0 Tc 0 Tw 7.29 0 Td [(t)-2 (o s)-1 (l)-2 (i)-2 (ght)-2 (l)-12 (y)20 ( opa)4 (l)-2 (e)4 (s)-1 (c)-6 (e)4 (nt)-2 ( a)4 (nd c)4 (ol)-2 (o)-10 (r)-7 (l)-2 (e)4 (s)-1 (s)-1 ( t)-2 (o pa)4 (l)-2 (e )-6 (y)20 (e)-6 (l)-2 (l)-2 (ow)2 (. )]TJ EMC /Lbl <>BDC /C2_0 1 Tf -8.79 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /StyleSpan <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 1.5 0 Td [(S)-8 (t)-6 (o)-4 (r)-1 (e r)-1 (eco)-4 (n)-4 (s)-5 (t)-6 (i)-6 (t)-6 (u)-4 (t)-6 (ed)-4 ( H)-2 (E)-3 (R)-16.9 (Z)6.9 (U)-1.9 (M)-5.1 (A)-2 ( i)-5.9 (n)-4 ( t)-6 (h)-4 (e )-10 (r)-1 (ef)-11 (r)-1 (i)-16 (g)6 (er)-11 (at)-6 (o)-4 (r)-1 ( at)-6 ( 2)]TJ EMC /StyleSpan <>BDC /C2_1 1 Tf 0 Tc 0 Tw 8.04 0 0 8.04 408.2787 362.2303 Tm <017C>Tj EMC /StyleSpan <>BDC /TT0 1 Tf 12 0 0 12 413.0787 357.6703 Tm [(C)-3 ( t)-2 (o 8)]TJ EMC /StyleSpan <>BDC /C2_1 1 Tf 8.04 0 0 8.04 442.4787 362.2303 Tm <017C>Tj EMC /StyleSpan <>BDC /TT0 1 Tf 12 0 0 12 447.2787 357.6703 Tm [(C)-3 ( \()3 (36\260F)6 ( t)-2 (o )-10 (46\260F)6 (\))]TJ EMC /LBody <>BDC -0.002 Tw 6.77 0 Td (; )Tj 0 Tw -31.76 -1.17 Td [(di)-2 (s)-1 (c)4 (a)4 (r)3 (d unus)-1 (e)4 (d H)2 (E)1 (R)-13 (Z)11 (U)-8 (M)-1 (A)2 ( a)4 (f)3 (t)-2 (e)4 (r)3 ( 28 d)-10 (a)-16 (y)20 (s)-1 (. )]TJ EMC /StyleSpan <>BDC 0.002 Tc -0.002 Tw 17.08 0 Td [(I)15 (f)5 ( H)-6 (E)-7 (R)-1 (Z)13 (U)4 (M)1 (A)4 ( is)1 ( r)-5 (e)6 (c)6 (o)2 (n)2 (s)1 (titu)2 (te)6 (d)2 ( w)4 (ith)2 ( S)-2 (W)-4 (F)-2 (I )]TJ EMC /LBody <>BDC 0 Tc 0 Tw -17.08 -1.17 Td [(w)2 (i)-2 (t)-2 (hout)-2 ( pr)3 (e)4 (s)-1 (e)4 (r)3 (va)4 (t)-2 (i)-2 (ve)4 (, us)-11 (e)-6 ( i)-2 (m)-2 (m)-2 (e)4 (di)-2 (a)4 (t)-2 (e)4 (l)-12 (y)20 ( a)4 (nd di)-2 (s)-1 (c)-6 (a)4 (r)3 (d )-10 (a)4 (n)-10 (y)20 ( unus)-11 (e)4 (d por)3 (t)-2 (i)-2 (on. )]TJ /TT1 1 Tf -0.004 Tc 0.004 Tw [(D)-2 (o )-14 (n)-8 (o)-4 (t)-1 ( f)-11 (reeze. )]TJ EMC /P <>BDC /TT3 1 Tf 0.002 Tc 0 Tw -4.5 -1.67 Td [(D)4 (ilu)2 (tio)2 (n )]TJ EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 3 -1.71 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 1.5 0 Td [(D)-2 (et)-6 (er)-1 (m)-6 (i)-6 (n)-4 (e t)-6 (h)-4 (e d)-4 (o)-4 (s)-15 (e \()-1 (m)-16 (g)6 (\) )-11 (o)-4 (f)-1 ( H)-1.9 (E)-3 (R)-7.1 (Z)-2.9 (U)-2 (M)-5 (A )]TJ /TT3 1 Tf 0 Tc 0 Tw 16.49 0 Td [([)-1 (s)-1 (e)4 (e )-6 (D)2 (os)-11 (age)4 ( and A)1 (dm)2 (i)-2 (ni)-2 (s)-1 (t)-2 (r)-1 (at)-2 (i)-2 (on \()3 (2.2)]TJ -0.033 Tc 0.033 Tw (\)])Tj /TT0 1 Tf 0 Tc 0 Tw 15.55 0 Td (. )Tj -32.04 -1.17 Td [(C)-3 (a)4 (l)-2 (c)4 (ul)-2 (a)4 (t)-2 (e)4 ( t)-2 (he)4 ( vol)-2 (um)-2 (e)4 ( of)3 ( t)-12 (he)4 ( 21 m)-2 (g)10 (/)-2 (m)-12 (L)11 ( r)-7 (e)4 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (e)4 (d H)2 (E)1 (R)-3 (Z)1 (U)2 (M)-1 (A)2 ( s)-1 (ol)-2 (ut)-2 (i)-2 (on ne)4 (e)4 (de)4 (d, )]TJ T* [(w)2 (i)-2 (t)-2 (hdr)3 (a)4 (w)2 ( t)-2 (hi)-2 (s)-1 ( a)4 (m)-2 (ount)-2 ( f)3 (r)3 (o)-10 (m)-2 ( t)-2 (he)4 ( vi)-2 (a)4 (l)-2 ( a)4 (nd a)4 (dd i)-2 (t)-2 ( t)-2 (o a)4 (n i)-2 (nf)3 (us)-1 (i)-2 (on ba)4 (g c)4 (ont)-2 (a)4 (i)-2 (ni)-2 (ng 250 m)-12 (L )]TJ 0 -1.16 TD [(of)3 ( 0.9%)3 ( S)-4 (odi)-2 (um)-2 ( C)-3 (hl)-2 (or)3 (i)-2 (d)10 (e )-6 (I)13 (nj)-2 (e)4 (c)4 (t)-2 (i)-2 (on, U)2 (S)-4 (P)-4 (. )]TJ /TT1 1 Tf -0.002 Tc 0.002 Tw [(DO)-4 ( N)-10 (O)-4 (T)-5 ( US)-6 (E)-5 ( DE)-5 (XT)-5 (RO)-4 (S)4 (E)-5 ( \()1 (5)-2 (%)-12 (\) )]TJ 0 -1.17 TD [(S)-6 (O)-4 (L)-5 (UT)-5 (I)-3 (O)-4 (N. )]TJ EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 0 Tw -1.5 -1.73 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(G)2 (e)4 (nt)-2 (l)-12 (y)20 ( i)-2 (nve)-6 (r)3 (t)-2 ( t)-2 (he)4 ( ba)-6 (g)10 ( t)-2 (o )-10 (m)-2 (i)-2 (x t)-2 (he)4 ( s)-1 (ol)-2 (ut)-2 (i)-2 (on. )]TJ EMC /Lbl <>BDC /C2_0 1 Tf -1.5 -1.71 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(T)1 (he)4 ( s)-1 (ol)-2 (ut)-2 (i)-2 (on of)3 ( H)2 (E)1 (R)-3 (Z)11 (U)-8 (M)-1 (A)2 ( f)3 (or)3 ( i)-2 (nf)3 (us)-1 (i)-2 (on di)-2 (l)-2 (ut)-2 (e)4 (d i)-2 (n pol)-12 (y)20 (vi)-2 (n)-20 (y)30 (l)-12 (c)4 (hl)-2 (or)3 (i)-2 (de)4 ( or)3 ( po)-10 (l)-12 (y)20 (e)4 (t)-2 (h)-20 (y)20 (l)-2 (e)4 (n)-10 (e )]TJ T* [(ba)4 (g)10 (s )-11 (c)4 (ont)-2 (a)4 (i)-2 (ni)-2 (ng)10 ( 0.9)-10 (%)3 ( S)-4 (odi)-2 (um)-2 ( C)-3 (hl)-2 (or)3 (i)-2 (de )-6 (I)23 (nj)-2 (e)4 (c)4 (t)-2 (i)-2 (on, )-10 (U)2 (S)-4 (P)-4 (, s)-1 (houl)-2 (d be)4 ( s)-1 (t)-2 (or)3 (e)4 (d a)4 (t)-2 ( 2\260C)-3 ( t)-2 (o )]TJ T* [(8\260C)-3 ( \()3 (36\260F)6 ( t)-2 (o 46\260F)6 (\) )-7 (f)3 (or)3 ( n)-10 (o m)-2 (or)3 (e)4 ( t)-2 (ha)4 (n 24 hour)3 (s)-1 ( pr)3 (i)-12 (or)3 ( t)-2 (o us)-1 (e)4 (. )]TJ /TT1 1 Tf -0.004 Tc 0.004 Tw [(D)-2 (o)-4 ( n)-8 (o)-4 (t)-1 ( f)-11 (reez)-10 (e. )]TJ EMC /Artifact <>BDC /TT0 1 Tf 0 Tc 0 Tw 14.75 -9.05 Td (5)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 31.3987 26.3903 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4557 0 obj <>>>/Resources 4509 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4558 0 obj <> endobj 4559 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
 endstream endobj 4560 0 obj <> endobj 4561 0 obj <>stream q 1 0 0 1 22.88446 17.268738 cm 0 0 612 792 re W n 1 0 0 1 -22.88446 -17.268738 cm BT /Artifact <>BDC /CS0 cs 0 scn /TT0 1 Tf 3 Tr 12 0 0 12 94.8845 55.9087 Tm ( )Tj 19.75 0 Td ( )Tj 19.25 0 Td ( )Tj /TT1 1 Tf -35.54 55.78 Td ( )Tj /TT0 1 Tf 17.75 0 Td [( )-2640 ( )]TJ /TT2 1 Tf -12.77 -1.17 Td ( )Tj /TT0 1 Tf 2.81 0 Td ( )Tj 3.97 -1.67 Td ( )Tj /TT1 1 Tf -11.76 -1.72 Td ( )Tj /TT0 1 Tf 0.002 Tc -0.002 Tw 10.97 0 Td ( )Tj 9.78 0 Td ( )Tj 14.33 0 Td ( )Tj 0 Tc 0 Tw -33.54 -1.16 Td ( )Tj 29.26 0 Td [( )-2890 ( )]TJ -25.71 -1.17 Td ( )Tj 27.48 0 Td ( )Tj /TT3 1 Tf 14.04 0 0 14.04 112.4064 614.8687 Tm ( )Tj 16.897 0 Td ( )Tj /TT0 1 Tf -0.013 Tc 0.013 Tw 12 0 0 12 102.8045 594.4687 Tm ( )Tj 0 Tc 0 Tw 37.6 0 Td ( )Tj -1.11 -1.16 Td ( )Tj 1.47 -1.17 Td ( )Tj -7.78 -1.17 Td ( )Tj -21.12 -1.17 Td ( )Tj 19.56 -1.66 Td ( )Tj 7.53 0 Td ( )Tj 1.75 -1.17 Td ( )Tj -1.57 -1.16 Td ( )Tj 1.36 -1.17 Td ( )Tj -19.19 -1.17 Td ( )Tj -11.69 -1.67 Td ( )Tj 14.47 -1.66 Td ( )Tj /TT1 1 Tf -18.48 -1.73 Td ( )Tj /TT0 1 Tf 21.08 0 Td ( )Tj 7.4 0 Td ( )Tj /TT1 1 Tf -28.48 -1.72 Td ( )Tj /TT0 1 Tf 20.56 0 Td ( )Tj 13.59 0 Td ( )Tj /TT1 1 Tf -34.15 -1.72 Td ( )Tj /TT0 1 Tf 22.78 0 Td ( )Tj 7.65 0 Td ( )Tj -27.17 -1.67 Td ( )Tj 15.22 -1.66 Td ( )Tj 0.002 Tc -0.002 Tw 10.49 -1.67 Td ( )Tj 5.75 0 Td ( )Tj 0 Tc 0 Tw -14.06 -1.16 Td ( )Tj 13.06 0 Td ( )Tj -33.01 -1.17 Td ( )Tj /TT1 1 Tf -0.71 -1.73 Td ( )Tj /C2_0 1 Tf 10.94 0 Td <0003>Tj /TT0 1 Tf 14.43 0 Td ( )Tj /TT1 1 Tf -25.37 -1.71 Td ( )Tj /C2_0 1 Tf 33.58 0 Td <0003>Tj /TT0 1 Tf -22.24 -1.17 Td ( )Tj -6.7 -1.67 Td ( )Tj 13.79 0 Td [( )-2490 ( )]TJ 15.59 0 Td ( )Tj /C2_0 1 Tf -30.47 -1.17 Td <0003>Tj /TT0 1 Tf 9.79 0 Td ( )Tj -0.004 Tc 0.004 Tw -1.7 -1.66 Td ( )Tj 0 Tc 0 Tw 8.1 0 Td ( )Tj -0.004 Tc 0.004 Tw 3.08 0 Td ( )Tj 8.39 0 Td ( )Tj 0 Tc 0 Tw -9.26 -1.17 Td ( )Tj 7.01 0 Td ( )Tj EMC /Lbl <>BDC /C2_1 1 Tf 0 Tr -29.42 48.01 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(E)1 (x)-10 (t)-2 (e)4 (ndi)-2 (ng)10 ( a)4 (dj)-2 (uva)4 (nt)-2 ( t)-2 (r)3 (e)4 (a)4 (t)-12 (m)-2 (e)4 (nt)-2 ( be)-6 (y)20 (ond on)-10 (e )-16 (y)20 (e)-6 (a)4 (r)3 ( i)-2 (s )-11 (not)-2 ( r)3 (e)4 (c)4 (om)-2 (m)-2 (e)4 (nde)4 (d )]TJ /TT2 1 Tf -0.004 Tc 0.004 Tw [([)-5 (s)-5 (e)-10 (e A)-13 (d)-4 (ver)-5 (s)-5 (e )]TJ 0 Tc 0 Tw 0 -1.17 TD [(R)1 (e)4 (ac)4 (t)-2 (i)-2 (ons )-11 (\()13 (6.1)]TJ -0.033 Tc 0.033 Tw 5.78 0 Td (\)])Tj /TT0 1 Tf 0 Tc 0 Tw 0.73 0 Td (. )Tj EMC /P <>BDC /TT2 1 Tf -11.01 -1.67 Td [(M)3 (e)4 (t)-2 (as)-1 (t)-2 (at)-2 (i)-2 (c)4 ( T)-4 (r)-1 (e)4 (at)-2 (m)2 (e)4 (nt)-2 (, B)1 (r)-1 (e)4 (as)-1 (t)-2 ( C)-3 (anc)4 (e)4 (r)-1 (: )]TJ EMC /Span <>BDC /C2_1 1 Tf 3 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /Span <>BDC /TT0 1 Tf 0.002 Tc -0.002 Tw 1.5 0 Td [(A)4 (d)2 (min)2 (is)1 (te)6 (r)5 ( H)4 (E)3 (R)-1 (Z)13 (U)4 (M)1 (A)4 (, )-8 (a)6 (lo)2 (n)2 (e)6 ( o)2 (r)5 ( in)2 ( c)6 (o)2 (mb)2 (in)2 (a)6 (tio)2 (n )-8 (w)4 (ith)2.1 ( p)2.1 (a)5.9 (c)6.1 (lita)5.9 (x)-8 (e)6 (l,)2 ( a)6 (t a)6 (n)2 ( in)2 (iti)10 (a)6 (l d)2 (o)2 (s)1 (e)6 ( o)2 (f )]TJ 0 Tc 0 Tw 0 -1.16 TD (4 )Tj -0.01 Tc 0.01 Tw [(m)-12 (g/)-12 (k)-20 (g a)-6 (s)-11 ( a)-6 ( 9)-9.9 (0)]TJ 0 Tc 0 Tw 6.33 0 Td [(-)3 (m)-2 (i)-2 (nut)-2 (e)4 ( i)-2 (nt)-2 (r)3 (a)4 (ve)4 (nous)-1 ( i)-2 (nf)3 (us)-1 (i)-2 (on f)3 (ol)-2 (l)-2 (ow)2 (e)4 (d b)-20 (y)20 ( s)-1 (ubs)-1 (e)4 (que)4 (nt)-2 ( onc)-6 (e )-6 (w)2 (e)4 (e)4 (kl)-22 (y )]TJ -6.33 -1.17 Td [(dos)-1 (e)4 (s)-1 ( of)3 ( 2 )]TJ -0.01 Tc 0.01 Tw [(m)-12 (g/)-12 (k)-20 (g )-10 (a)-6 (s)-11 ( 3)-10 (0)]TJ 0 Tc 0 Tw 9.19 0 Td [(-)-7 (m)-2 (i)-2 (nut)-2 (e)4 ( i)-2 (nt)-2 (r)3 (a)4 (ve)4 (nous)-1 ( i)-2 (nf)3 (us)-1 (i)-2 (ons)-1 ( unt)-2 (i)-2 (l)-2 ( di)-2 (s)-1 (e)4 (a)4 (s)-1 (e)4 ( pr)3 (ogr)3 (e)4 (s)-11 (s)-1 (i)-2 (on. )]TJ EMC /Span <>BDC /TT3 1 Tf -0.002 Tc 14.04 0 0 14.04 94.8845 614.8687 Tm [(2)-6.3 (.3 )]TJ EMC /Span <>BDC 0.004 Tc -0.006 Tw 3.846 0 Td [(Im)16.5 (p)4.5 (or)3.5 (t)3.7 (an)4.5 (t)3.6 ( D)16.6 (os)8.4 (in)13 (g C)8 (on)4.5 (s)8.4 (id)4.5 (e)3.5 (r)12.1 (at)12.2 (i)8.5 (on)4.4 (s )]TJ EMC /P <>BDC /TT0 1 Tf -0.013 Tc 0.013 Tw 12 0 0 12 94.8845 594.4687 Tm (If )Tj 0 Tc 0 Tw 0.91 0 Td [(t)-2 (he)4 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 ( ha)4 (s)-1 ( m)-2 (i)-2 (s)-1 (s)-1 (e)4 (d )-10 (a)4 ( dos)-1 (e)4 ( of)3 ( H)2 (E)1 (R)-13 (Z)11 (U)2 (M)-1 (A)2 ( b)-20 (y)10 ( one)4 ( w)2 (e)4 (e)4 (k o)-10 (r)3 ( l)-2 (e)4 (s)-1 (s)-1 (, t)-2 (he)4 (n t)-2 (h)-10 (e)4 ( us)-1 (ua)4 (l)-2 ( m)-2 (a)4 (i)-2 (nt)-2 (e)4 (na)4 (nc)-6 (e )]TJ -0.91 -1.16 Td [(dos)-1 (e)4 ( \()3 (w)2 (e)-6 (e)4 (kl)-12 (y)20 ( s)]TJ 0.002 Tc -0.002 Tw 5.94 0 Td [(c)6 (h)2 (e)6 (d)2 (u)2 (le)6 (: 2)-8 ( mg)12 (/k)-8 (g)12 (; th)2 (r)5 (e)6 (e)]TJ 0 Tc 0 Tw 9.47 0 Td [(-)3 (w)2 (e)-6 (e)4 (kl)-12 (y)20 ( s)-11 (c)4 (h)-10 (e)4 (dul)-2 (e)4 (:)-2 ( 6 m)-2 (g)10 (/)-2 (k)-10 (g)10 (\))3 ( s)-1 (houl)-2 (d b)-10 (e)4 ( a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d a)4 (s )]TJ -15.41 -1.17 Td [(s)-1 (oon a)4 (s)-1 ( pos)-1 (s)-1 (i)-2 (bl)-2 (e)4 (. D)2 (o not)-2 ( w)2 (a)4 (i)-2 (t)-2 ( unt)-2 (i)-2 (l)-2 ( t)-2 (he)4 ( ne)4 (x)-10 (t)-2 ( pl)-2 (a)4 (nne)14 (d c)-6 (y)20 (c)-6 (l)-2 (e)4 (. S)-4 (ubs)-1 (e)4 (que)4 (nt)-2 ( H)2 (E)1 (R)-13 (Z)11 (U)2 (M)-1 (A)2 ( m)-12 (a)4 (i)-2 (nt)-2 (e)4 (na)4 (nc)-6 (e )]TJ 0 -1.17 TD [(dos)-1 (e)4 (s)-1 ( s)-1 (houl)-2 (d be)4 ( a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d 7 da)-16 (y)20 (s)-1 ( o)-10 (r)3 ( 21 da)-16 (y)20 (s)-1 ( l)-2 (a)4 (t)-12 (e)4 (r)3 ( a)4 (c)-6 (c)4 (or)3 (di)-2 (n)-10 (g)10 ( t)-2 (o t)-2 (he)4 ( w)-8 (e)4 (e)4 (kl)-12 (y )10 (or)3 ( t)-2 (hr)-7 (e)4 (e)4 (-)]TJ -0.004 Tc 0.004 Tw 34.52 0 Td [(w)-2 (ee)]TJ -0.02 Tc 0.02 Tw [(k)-20 (l)-42 (y )]TJ -0.004 Tc 0.004 Tw -34.52 -1.17 Td [(s)-5 (ch)-4 (ed)-4 (u)-4 (l)-6 (es)-5 (,)-4 ( r)-1 (es)-5 (p)-14 (ect)-6 (i)-6 (v)-4 (el)-25.9 (y)]TJ 0 Tc 0 Tw 9.21 0 Td (. )Tj EMC /P <>BDC -9.21 -1.66 Td [(I)13 (f)-7 ( t)-2 (he)4 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 ( ha)4 (s)-1 ( m)-2 (i)-2 (s)-1 (s)-1 (e)4 (d )-10 (a)4 ( dos)-1 (e)4 ( of)3 ( H)2 (E)1 (R)-13 (Z)11 (U)2 (M)-1 (A)2 ( b)-20 (y)10 ( m)-2 (or)3 (e)4 ( t)-2 (ha)4 (n one)4 ( w)-8 (e)4 (e)4 (k, a )-6 (r)-7 (e)4 (-)3 (l)-2 (oa)4 (di)-2 (n)-10 (g)10 ( dos)-1 (e)4 ( of )]TJ T* [(H)2 (E)1 (R)-3 (Z)11 (U)2 (M)-1 (A)2 ( s)-1 (houl)-2 (d b)-10 (e)4 ( a)-6 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d ove)4 (r)3 ( a)4 (pp)-10 (r)3 (ox)-10 (i)8 (m)-2 (a)4 (t)-2 (e)4 (l)-12 (y)20 ( 90 m)-2 (i)-2 (nut)-2 (e)4 (s)-1 ( \()3 (w)-8 (e)4 (e)4 (k)-10 (l)-12 (y)20 ( s)-1 (c)4 (he)4 (dul)-12 (e)4 (:)-2 ( 4 m)-2 (g)10 (/)-2 (k)-10 (g)10 (\) )]TJ 0 -1.16 TD [(a)4 (s)-1 ( s)-1 (oon a)4 (s)-1 ( pos)-1 (s)-1 (i)-2 (bl)-2 (e)4 (. S)-4 (ubs)-1 (e)4 (que)4 (nt)-2 ( H)2 (E)1 (R)-13 (Z)11 (U)2 (M)-1 (A)2 ( m)-2 (a)4 (i)-2 (n)-10 (t)-2 (e)4 (na)4 (nc)4 (e)4 ( dos)-11 (e)4 (s)-1 ( \()3 (w)2 (e)-6 (e)4 (kl)-22 (y)20 ( s)-1 (c)-6 (he)4 (dul)-2 (e)4 (:)-2 ( 2 m)-2 (g)10 (/)-2 (k)-10 (g)10 (; )]TJ -0.004 Tc 0.004 Tw 0 -1.17 TD [(t)-6 (h)-4 (r)-1 (ee)]TJ 0 Tc 0 Tw [(-)3 (w)-8 (e)4 (e)4 (kl)-22 (y)20 ( s)-1 (c)4 (h)-10 (e)4 (dul)-2 (e)4 ( 6 )-10 (m)-2 (g)10 (/)-2 (k)-10 (g)10 (\))3 ( s)-1 (houl)-2 (d be)4 ( a)4 (dm)-2 (i)-2 (ni)-12 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d 7 da)-16 (y)20 (s)-1 ( or)3 ( 21 d)-10 (a)-16 (y)20 (s)-1 ( l)-12 (a)4 (t)-2 (e)4 (r)3 ( a)-6 (c)4 (c)4 (or)3 (di)-2 (n)-10 (g)10 ( t)-2 (o t)-2 (he )]TJ -0.004 Tc 0.004 Tw T* [(w)-2 (eek)-4 (l)-26 (y)16 ( o)-4 (r)-1 ( t)-6 (h)-4 (r)-11 (ee)]TJ 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 6.54 0 Td [(w)-12 (eek)-4 (l)-26 (y)16 ( s)-15 (ch)-4 (ed)-4 (u)-4 (l)-6 (es)-5 (,)-4 ( r)-11 (es)-5 (p)-4 (ect)-5.9 (i)-6.1 (v)-4 (el)-26 (y)]TJ 0 Tc 0 Tw 12.36 0 Td (. )Tj EMC /P <>BDC /TT2 1 Tf -18.9 -1.67 Td [(I)3 (nf)-2 (us)-1 (i)-2 (on R)1 (e)4 (ac)4 (t)-2 (i)-2 (ons)]TJ /T1_0 1 Tf (\002 )Tj /TT2 1 Tf -0.004 Tc 0.004 Tw 0 -1.66 TD [([)-5 (s)-5 (ee )]TJ 0 Tc 0.02 Tw [(B)1 (ox)4 (e)4 (d W)13 (ar)-1 (ni)-2 (ng)]TJ 0 Tw [(, )-10 (W)13 (a)-10 (r)-1 (ni)-2 (ngs)-1 ( and P)1 (r)-1 (e)4 (c)4 (aut)-2 (i)-2 (on)]TJ 0.001 Tc -0.001 Tw (s \()Tj 0 Tc 0 Tw 19.97 0 Td (5.2)Tj -0.033 Tc 0.033 Tw (\)])Tj /T1_0 1 Tf (\002 )Tj EMC /Lbl <>BDC /C2_1 1 Tf 0 Tc 0 Tw -16.97 -1.73 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(D)2 (e)4 (c)4 (r)-7 (e)4 (a)4 (s)-1 (e)4 ( t)-2 (h)-10 (e)4 ( r)3 (a)4 (t)-2 (e)4 ( o)-10 (f)3 ( i)-2 (nf)3 (us)-11 (i)-2 (on f)3 (or)3 ( m)-2 (i)-2 (l)-2 (d or)3 ( m)-2 (ode)4 (r)3 (a)4 (t)-2 (e )-6 (i)-2 (nf)3 (us)-1 (i)-2 (on r)3 (e)4 (a)4 (c)4 (t)-2 (i)-2 (ons )]TJ EMC /Lbl <>BDC /C2_1 1 Tf -1.5 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(I)13 (nt)-2 (e)-6 (r)3 (r)3 (upt)-2 ( t)-2 (he)4 ( i)-2 (nf)3 (us)-1 (i)-2 (on i)-2 (n )-10 (pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h d)-10 (y)20 (s)-1 (pne)-6 (a)4 ( or )-7 (c)4 (l)-2 (i)-2 (ni)-2 (c)4 (a)4 (l)-2 (l)-12 (y)20 ( s)-1 (i)-12 (g)10 (ni)-2 (f)3 (i)-2 (c)4 (a)4 (nt)-2 ( h)-20 (y)20 (p)-10 (ot)-2 (e)4 (ns)-1 (i)-2 (on )]TJ EMC /Lbl <>BDC /C2_1 1 Tf -1.5 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(D)2 (i)-2 (s)-1 (c)4 (ont)-2 (i)-2 (nue)4 ( H)2 (E)1 (R)-3 (Z)1 (U)2 (M)-1 (A)-8 ( f)3 (or)3 ( s)-1 (e)4 (ve)-6 (r)3 (e)4 ( or)3 ( l)-2 (i)-2 (f)-7 (e)4 (-)3 (t)-2 (hr)3 (e)-6 (a)4 (t)-2 (e)-6 (ni)-2 (ng )10 (i)-2 (nf)3 (us)-1 (i)-2 (on r)3 (e)-6 (a)4 (c)4 (t)-2 (i)-2 (ons)-1 (. )]TJ EMC /P <>BDC /TT2 1 Tf -4.5 -1.67 Td [(C)-3 (ar)-1 (di)-2 (om)2 (y)4 (opat)-2 (hy )]TJ EMC /P <>BDC T* ([)Tj /TT0 1 Tf 0.39 0 Td (s)Tj /TT2 1 Tf -0.004 Tc 0.004 Tw 0.39 0 Td (ee )Tj 0 Tc 0.02 Tw [(B)1 (ox)4 (e)4 (d W)13 (ar)-1 (ni)-2 (ng)]TJ 0 Tw [(, )-10 (W)13 (a)-10 (r)-1 (ni)-2 (ngs)-1 ( and P)1 (r)-1 (e)4 (c)4 (aut)-2 (i)-2 (ons)-1 ( \()3 (5.1)]TJ -0.033 Tc 0.033 Tw (\)] )Tj EMC /P <>BDC /TT0 1 Tf 0.002 Tc -0.002 Tw -0.78 -1.67 Td [(A)4 (s)1 (s)1 (e)6 (s)1 (s)1 ( le)6 (f)5 (t v)2 (e)6 (n)2 (tr)5 (ic)6 (u)2 (la)-4 (r)5 ( e)6 (j)-10 (e)6 (c)6 (tio)2 (n)2 ( f)5 (r)5 (a)-4 (c)6 (tio)2 (n)2 ( \()-5 (L)13 (V)4 (E)-7 (F)7.9 (\))5.1 ( p)-7.9 (r)5 (io)2 (r)5.1 ( to)2 ( in)2 (itia)6 (tio)2 (n)2 ( o)2 (f)5 ( H)4 (E)3 (R)-1 (Z)13 (U)4 (M)1 (A )-6 (a)6 (n)2 (d)2 ( a)6 (t r)-5 (e)-4 (g)12 (u)2 (la)6 (r )]TJ 0 Tc 0 Tw 0 -1.16 TD [(i)-2 (nt)-2 (e)4 (r)3 (va)4 (l)-2 (s)-1 ( dur)3 (i)-2 (ng)10 ( t)-12 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (n)-10 (t)-2 (. W)-6 (i)-2 (t)-2 (hhol)-2 (d H)2 (E)1 (R)-3 (Z)11 (U)2 (M)-1 (A)2 ( dos)-1 (i)-2 (ng)10 ( f)3 (or )-7 (a)4 (t)-2 ( l)-2 (e)4 (a)4 (s)-1 (t)-2 ( 4 w)2 (e)-6 (e)-6 (ks)-1 ( f)3 (or)3 ( e)4 (i)-2 (t)-2 (he)4 (r)3 ( o)-10 (f)3 ( t)-2 (he )]TJ 0 -1.17 TD [(f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng)10 (: )]TJ EMC /Lbl <>BDC /C2_1 1 Tf 3 -1.73 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /C2_0 1 Tf 1.5 0 Td [<0095>-1 <0003001400190008>3 <00030044>4 <00450056>-1 <0052004F>-2 <00580057>-2 <0048>4 <000300470048>4 <0046>-6 <0055>3 <0048>4 <0044>4 <0056>-11 <00480003>-6 <004C>-2 <00510003>-10 <002F>21 <0039>2 <0028>-9 <0029>6 <00030049>3 <0055>3 <00520050>-2 <00030053>-10 <0055>3 <0048>]TJ /TT0 1 Tf 17.4 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.33 0 Td [(t)-6 (r)-11 (eat)-6 (m)-16 (en)-4 (t)-6 ( v)-4 (al)-6 (u)-4 (es )]TJ EMC /Lbl <>BDC /C2_1 1 Tf 0 Tc 0 Tw -19.23 -1.71 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /C2_0 1 Tf 1.5 0 Td [<002F>11 <0039>2 <0028>-9 <0029>6 <000300450048>4 <004F>-2 <0052005A>2 <0003004C>-2 <00510056>-1 <0057>-2 <004C>-2 <0057>-2 <00580057>-2 <004C>-2 <005200510044>4 <004F>-2 <0003004F>-2 <004C>-2 <0050>-2 <004C>-2 <0057>-2 <0056>-1 <000300520049>3 <0003005100520055>3 <0050>-2 <0044>4 <004F>-2 <00030044>4 <0051004700030095>-1 <0003001400130008>3 <00030044>4 <00450056>-1 <0052004F>-2 <00580057>-2 <0048>4 <000300470048>4 <0046>-6 <0055>3 <0048>4 <0044>4 <0056>-11 <0048>4 <0003004C>-2 <00510003>-10 <002F>11 <0039>2 <0028>-9 <00290003>]TJ EMC /P <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw T* [(f)-1 (r)-1 (o)-4 (m)-6 ( p)-4 (r)-1 (et)-6 (r)-11 (eat)-6 (m)-6 (en)-4 (t)-6 ( v)-4 (al)-6 (u)-4 (es)-15 (. )]TJ -0.002 Tc 0.002 Tw -4.5 -1.67 Td [(HE)-1 (R)-5 (Z)9 (UM)-3 (A m)-14 (a)-18 (y)18 ( b)-2 (e )]TJ 0.002 Tc -0.002 Tw 8.35 0 Td [(r)-5 (e)6 (s)1 (u)-8 (me)6 (d)2 ( if)5 (,)2 ( w)4 (ith)2 (in)2 ( 4)]TJ 0 Tc 0 Tw 8.07 0 Td [(\2268 w)2 (e)4 (e)4 (ks)-11 (, t)-2 (he )-6 (L)21 (V)-8 (E)1 (F )-4 (r)3 (e)4 (t)-2 (ur)3 (ns)-1 ( t)-2 (o nor)-7 (m)-2 (a)4 (l)-2 ( l)-2 (i)-2 (m)-2 (i)-2 (t)-2 (s)-1 ( a)4 (nd t)-2 (he )]TJ EMC /P <>BDC /C2_0 1 Tf -16.42 -1.17 Td [<0044>4 <00450056>-1 <0052004F>-2 <00580057>-2 <0048>4 <000300470048>4 <0046>4 <0055>-7 <0048>4 <0044>4 <0056>-1 <00480003>-6 <0049>3 <0055>3 <00520050>-2 <00030045>-10 <0044>4 <0056>-1 <0048>4 <004F>-2 <004C>-2 <00510048>4 <0003004C>-2 <0056>-1 <00030094>-1 <0003001400180008>3 <00110003>]TJ EMC /P <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 0 -1.66 TD [(P)-8 (er)-1 (m)-6 (an)-4 (en)-4 (t)-6 (l)-16 (y)16 ( d)-4 (i)-6 (s)-15 (co)-4 (n)-4 (t)-6 (i)-6 (n)-4 (u)-4 (e )-9.9 (H)-2.1 (E)-3 (R)-6.9 (Z)7 (U)-2 (M)-5 (A )-12 (f)-1 (o)-4 (r)-1 ( a p)-14 (er)-1 (s)-5 (i)-6 (s)-5 (t)-16 (en)-4 (t)-6 ( \()-1 (> 8 )-4 (w)-12 (eek)-4 (s)-5 (\) )-11 (L)7 (V)-12 (E)-3 (F)2 ( d)-14 (e)-10 (cl)-6 (i)-6 (n)-4 (e o)-4 (r)-1 ( f)-1 (o)-4 (r )]TJ 0 Tc 0 Tw 0 -1.17 TD [(s)-1 (us)-1 (pe)4 (ns)-1 (i)-2 (on of)3 ( H)2 (E)1 (R)-3 (Z)1 (U)2 (M)-11 (A)2 ( dos)-1 (i)-2 (ng)10 ( on m)-2 (or)3 (e)4 ( t)-2 (h)-10 (a)4 (n 3 )-10 (oc)4 (c)4 (a)4 (s)-1 (i)-2 (ons)-1 ( f)3 (or )-7 (c)4 (a)4 (r)3 (di)-2 (om)-22 (y)20 (o)-10 (pa)4 (t)-2 (h)-10 (y)20 (. )]TJ EMC /Artifact <>BDC 19.25 -7.77 Td (4)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 32.8845 27.2687 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4562 0 obj <>>>/Resources 4508 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4563 0 obj <> endobj 4564 0 obj <>stream /
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560.3892 494.2303 Tm ( )Tj ET Q Q q 1 0 0 1 -26.388794 -22.390259 cm BT /CS0 cs 0 scn /TT1 1 Tf 3 Tr 12 0 0 12 503.6288 480.1903 Tm ( )Tj 0.002 Tc -0.002 Tw 2.79 -1.16 Td ( )Tj ET Q q 72.48 297.24 467.041 394.2 re W n q 1 0 0 1 -26.388794 -22.390259 cm BT /CS0 cs 0 scn /TT1 1 Tf 0.004 Tc -0.004 Tw 3 Tr 12 0 0 12 396.5888 452.2303 Tm ( )Tj 13.68 0 Td ( )Tj ET Q Q q 1 0 0 1 -26.388794 -22.390259 cm BT /CS0 cs 0 scn /TT2 1 Tf 0.001 Tc -0.001 Tw 3 Tr 12 0 0 12 218.5091 424.1503 Tm ( )Tj /TT1 1 Tf 0 Tc 0 Tw 15.81 0 Td ( )Tj -15.68 -1.66 Td ( )Tj 0.004 Tc -0.004 Tw 8.35 -1.67 Td ( )Tj 0 Tc 0 Tw -6.77 -1.16 Td ( )Tj 0.004 Tc -0.004 Tw 20.77 -1.17 Td ( )Tj /TT2 1 Tf 0 Tc 0 Tw -2.58 -1.17 Td ( )Tj /TT0 1 Tf -27.27 -1.17 Td ( )Tj ET Q /CS0 cs 0 scn 72 691.44 0.48 0.48 re f 72 691.44 0.48 0.48 re f 72.48 691.44 467.041 0.48 re f 539.52 691.44 0.48 0.48 re f 539.52 691.44 0.48 0.48 re f 72 297.24 0.48 394.2 re f 72 296.76 0.48 0.481 re f 72 296.76 0.48 0.481 re f 72.48 296.76 467.041 0.481 re f 539.52 297.24 0.48 394.2 re f 539.52 296.76 0.48 0.481 re f 539.52 296.76 0.48 0.481 re f q 1 0 0 1 -26.388794 -22.390259 cm BT /TT1 1 Tf 3 Tr 14.04 0 0 14.04 105.3526 282.0704 Tm ( )Tj 16.204 0 Td ( )Tj -15.453 -2.009 Td ( )Tj 13.008 0 Td ( )Tj /TT0 1 Tf 12 0 0 12 338.2688 233.5903 Tm ( )Tj 17.94 0 Td ( )Tj -24.44 -1.17 Td ( )Tj 8.49 0 Td ( )Tj -0.004 Tc 0.004 Tw 14.57 0 Td ( )Tj 0 Tc 0 Tw -33.94 -1.17 Td ( )Tj /TT3 1 Tf 0.85 -1.72 Td ( )Tj /TT0 1 Tf -0.004 Tc 0.004 Tw 13.01 0 Td ( )Tj 0 Tc 0 Tw -0.39 -1.17 Td ( )Tj /TT3 1 Tf -12.62 -1.73 Td ( )Tj /TT0 1 Tf 25.56 0 Td ( )Tj -0.004 Tc 0.004 Tw -18.57 -1.65 Td [( )-4730 ( )]TJ 0 Tc 0 Tw -7.4 -1.17 Td [( )-1660 ( )]TJ 16.04 0 Td ( )Tj ET Q EMC 1 0 0 1 -26.388794 -22.390259 cm BT /P <>BDC /TT1 1 Tf -0.004 Tc 0.002 Tw 14.04 0 0 14.04 98.3888 717.3103 Tm [(FUL)-3.6 (L)-3.7 ( PRE)-3.6 (S)-3.6 (CRI)-8.1 (B)-3.7 (I)-8.2 (NG)-3.8 ( I)-8.2 (NFO)-3.8 (RMAT)-3.7 (I)-8.1 (O)4.7 (N)]TJ /T1_0 1 Tf (\002 )Tj EMC /P <>BDC /TT1 1 Tf 2.966 -1.607 Td [(W)-4 (ARNI)-8.2 (NG)-3.7 (:)-4.4 ( CARD)-8.4 (I)-8.2 (O)-3.8 (MYO)-3.8 (PAT)-3.6 (H)-3.8 (Y,)-1.9 ( I)-8.1 (NFUS)-3.5 (I)-8.2 (O)-3.7 (N RE)-3.7 (ACT)-3.6 (I)-8.2 (O)-3.8 (NS)-3.6 (,)]TJ /T1_0 1 Tf (\002 )Tj /TT1 1 Tf 0.004 Tw -0.137 -1.145 Td [(E)-3.7 (MB)-3.7 (RYO)]TJ 0 Tc 0 Tw 4.487 0 Td (-)Tj -0.002 Tw [(F)4.1 (ETA)4 (L TOX)4 (I)-4.1 (C)4 (I)-4.2 (TY)4 (, )]TJ -0.009 Tc 0.009 Tw 9.455 0 Td [(a)-13.3 (nd )]TJ -0.004 Tc 0.002 Tw 1.853 0 Td [(PUL)-3.6 (MO)-3.8 (NARY T)-3.7 (O)-3.8 (XI)-8.2 (CI)-8.2 (T)-3.7 (Y)]TJ /T1_0 1 Tf (\002 )Tj EMC /P <>BDC /TT1 1 Tf 0 Tc 0 Tw 12 0 0 12 104.0288 658.1503 Tm [(C)2 (ar)4 (d)-4 (i)-2 (om)13 (yop)-4 (at)3 (h)-4 (y )]TJ EMC /P <>BDC 0.004 Tc -0.004 Tw 0 -1.66 TD [(A)6 (dm)17 (i)2 (ni)2 (s)3 (t)7 (r)8 (a)4 (t)7 (i)2 (o)4 (n o)4 (f)-3 ( t)7 (r)8 (a)4 (s)3 (t)-3 (uz)7.9 (um)17.1 (a)3.9 (b pr)8 (o)4 (duc)8 (t)7 (s)3 ( c)8 (a)4 (n r)-2 (e)8 (s)3 (ul)2 (t)7 ( i)2 (n s)3 (ub)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc -0.002 Tw 24.99 0 Td [(c)6 (li)10 (n)-2 (ic)6 (a)2 (l a)2 (n)-2 (d)8 ( c)6 (lin)-2 (ic)6 (a)2 (l c)6 (a)2 (r)6 (d)-2 (ia)2 (c )]TJ -0.004 Tc 0.004 Tw -24.99 -1.17 Td [(f)-11 (a)-4 (i)-6 (l)4 (u)-8 (re.)-4 ( T)-7 (h)-8 (e i)-6 (n)-8 (ci)-6 (d)-8 (en)-8 (ce a)-3.9 (n)-8.1 (d)-7.9 ( s)-5.1 (ev)-3.9 (eri)-6 (t)-1 (y)-4 ( w)-12 (a)-4 (s)-5 ( h)-8 (i)-6 (g)-4 (h)-8 (es)-5 (t )9 (i)-6 (n)-8 ( p)-8 (a)-4 (t)-1 (i)-6 (en)-8 (t)-1 (s)-5 ( recei)-6 (v)-4 (i)-6 (n)-8 (g)-4 ( t)-1 (ra)-14 (s)-5 (t)-1 (u)-8 (zu)-8.1 (m)9.1 (a)-4 (b)-8 ( w)-12 (i)-6 (t)-1 (h )]TJ 0 -1.17 TD [(a)-4 (n)-8 (t)-1 (h)-8 (ra)-4 (cy)-4 (cl)-6 (i)-6 (n)-8 (e)]TJ 0 Tc 0 Tw [(-)3 (c)4 (on)-4 (t)3 (ai)-2 (n)-4 (i)-2 (n)-4 (g c)4 (h)-4 (e)-6 (m)13 (ot)3 (h)-4 (e)4 (r)4 (ap)-4 (y r)-6 (e)4 (gi)-12 (m)13 (e)-6 (n)-4 (s)-1 (. )]TJ EMC /P <>BDC 0.004 Tc -0.004 Tw 0 -1.66 TD [(E)1 (v)4 (a)4 (l)2 (ua)4 (t)7 (e)8 ( l)2 (e)8 (f)-3 (t)7 ( v)4 (e)8 (nt)7 (r)8 (i)2 (c)8 (ul)2 (a)3.9 (r)8.1 ( f)-3 (unc)8 (t)7 (i)2 (o)4 (n i)12 (n a)4 (l)2 (l)2 ( pa)4 (t)7 (i)2 (e)8 (nt)17 (s)3 ( pr)8 (i)2 (o)4 (r)8 ( t)7 (o)4 ( a)4 (nd dur)8 (i)2 (ng)4 ( t)7 (r)18 (e)8 (a)4 (t)-3 (m)16.9 (e)8.1 (nt)7 ( w)-4.1 (i)2 (t)7 (h )]TJ -0.004 Tc 0.004 Tw 0 -1.17 TD [(H)-6 (E)-7 (R)-2 (Z)3 (U)-2 (MA)-2 (.)-4 ( D)-2 (i)-6 (s)-15 (co)-4 (n)-8 (t)-1 (i)-6 (n)-8 (u)-8 (e H)-6 (E)-6.9 (R)-2 (Z)3 (U)-2.1 (MA )-11.9 (t)-1 (rea)-14 (t)-11 (m)9 (e)-10 (n)-8 (t)-1 ( i)-6 (n)-8 ( p)-8 (a)-4 (t)-1 (i)-6 (en)]TJ 0 Tc 0 Tw 24.73 0 Td [(t)3 (s)-1 ( r)4 (e)4 (c)4 (e)4 (i)-2 (vi)-2 (n)-4 (g ad)-4 (j)3 (u)-4 (van)-4 (t)3 ( t)3 (h)-4 (e)4 (r)4 (ap)-4 (y )]TJ 0.002 Tc -0.002 Tw -24.73 -1.16 Td [(a)2 (n)-2 (d )8 (w)-6 (it)5 (h)-2 (h)-2 (o)2 (l)10 (d)-2 ( HE)-1 (R)4 (Z)9 (U)4 (M)6 (A)4 ( in)-2 ( p)-2 (a)2 (t)5 (ie)6 (n)-2 (t)5 (s)1 ( w)-6 (it)5 (h)-2 ( m)15 (e)-4 (t)5 (a)2 (s)1 (t)5 (a)2 (t)5 (ic)6.1 ( d)-2.1 (is)0.9 (e)6 (a)2.1 (s)0.9 (e)6.1 ( f)-5.1 (o)2 (r)6 ( c)6 (lin)-2 (ic)6 (a)2 (lly)2 ( s)1 (ig)2 (n)-2 (i)10 (f)-5 (ic)6 (a)2 (n)-2 (t )]TJ -0.004 Tc 0.004 Tw T* [(d)-8 (ecrea)-4 (s)-5 (e i)-6 (n)-8 ( l)-6 (ef)-11 (t)-1 ( v)-4 (en)-8 (t)-1 (ri)-16 (cu)-7.9 (l)-6.1 (a)-4 (r f)-10.9 (u)-8 (n)-8 (ct)-1 (i)-6 (o)-4 (n )]TJ /TT2 1 Tf 0 Tc 0 Tw 15.48 0 Td [([)3 (s)-1 (e)4 (e)4 ( D)2 (os)-1 (age)4 ( an)-4 (d A)-3 (d)10 (m)-12 (i)-2 (n)6 (i)-2 (s)-1 (t)-2 (r)-1 (at)-2 (i)-2 (o)10 (n)-4 ( \()3 (2.3)10 (\))3 ( an)-4 (d W)-1 (ar)-1 (n)-4 (i)-2 (n)-4 (gs )]TJ -15.48 -1.17 Td [(an)-4 (d P)1 (r)-1 (e)4 (c)4 (au)-4 (t)-2 (i)-2 (on)-4 (s)-1 ( \()3 (5.1)]TJ -0.003 Tc 0.003 Tw (\)])Tj /TT1 1 Tf 0 Tc 0 Tw (. )Tj EMC /P <>BDC 0 -1.67 TD [(I)-1 (n)-4 (f)3 (u)-4 (s)-1 (i)-2 (on)-4 ( R)2 (e)4 (ac)4 (t)3 (i)-2 (on)-4 (s)-1 (;)3 ( P)11 (u)-4 (l)-2 (m)13 (on)-4 (ar)4 (y T)-3 (oxi)-2 (c)4 (i)-2 (t)3 (y )]TJ EMC ET /P <>BDC q 1 0 0 1 26.388794 22.390259 cm 72.48 297.24 467.041 394.2 re W n 1 0 0 1 -26.388794 -22.390259 cm BT 0.004 Tc -0.004 Tw 12 0 0 12 104.0288 494.2303 Tm [(A)6 (dm)17 (i)2 (ni)2 (s)3 (t)7 (r)8 (a)4 (t)7 (i)2 (o)4 (n o)4 (f)-3 ( t)7 (r)8 (a)4 (s)3 (t)-3 (uz)7.9 (um)17.1 (a)3.9 (b pr)8 (o)4 (duc)8 (t)7 (s)3 ( c)8 (a)4 (n r)-2 (e)8 (s)3 (ul)2 (t)7 ( i)2 (n s)3 (e)8 (r)8 (i)2 (o)4 (us)3 ( a)4 (nd )10 (f)-3 (a)4 (t)7 (a)14 (l)2 ( i)2 (n)10 (f)-3 (us)2.9 (i)2 (o)14 (n r)8 (e)8 (a)4 (c)8 (t)7 (i)2 (o)4 (ns )]TJ ET Q BT 12 0 0 12 104.0288 480.1903 Tm [(an)-4 (d)-4 ( p)6 (u)-4 (l)-2 (m)13 (on)-4 (ar)4 (y t)3 (oxi)-2 (c)4 (i)-2 (t)3 (y)-10 (. S)-4 (ym)13 (p)-4 (t)3 (o)-10 (m)13 (s)-1 ( u)-4 (s)-1 (u)-4 (al)-2 (l)-2 (y oc)4 (c)-6 (u)-4 (r)4 ( d)-4 (u)-4 (r)4 (i)-2 (n)-4 (g or)4 ( w)2 (i)-2 (t)3 (h)-4 (i)-2 (n)-4 ( 24 )10 (h)-4 (ou)-4 (r)4 (s)-1 ( of )]TJ 0.002 Tc -0.002 Tw 0 -1.16 TD [(HE)-1 (R)4 (Z)9 (U)4 (M)6 (A)4 ( a)2 (d)-12 (m)15 (in)-2 (is)1 (t)5 (r)6 (a)-8 (t)5 (io)2 (n)-2 (.)2 ( I)1 (n)-2 (t)5 (e)6 (r)6 (r)6 (u)-2 (p)-2 (t)5 ( HE)-1 (R)4 (Z)9 (U)-6 (M)6 (A)4 ( in)-2 (f)-5.1 (u)-2 (s)1 (io)11.9 (n)-2 ( f)-5.1 (o)2.1 (r)5.9 ( d)-1.9 (y)1.9 (s)11 (p)-2 (n)-2 (e)16 (a)2 ( o)2 (r)6 ( c)6 (lin)-2 (ic)6 (a)2 (lly )]TJ 0 Tc 0 Tw 0 -1.17 TD [(s)-1 (i)-2 (gn)]TJ ET q 1 0 0 1 26.388794 22.390259 cm 72.48 297.24 467.041 394.2 re W n 1 0 0 1 -26.388794 -22.390259 cm BT 0.004 Tc -0.004 Tw 12 0 0 12 124.7888 452.2303 Tm [(i)12 (f)-3 (i)2 (c)8 (a)4 (nt)7 ( hy)4 (po)4 (t)7 (e)8 (ns)3 (i)2 (o)14 (n.)14 ( M)8 (o)3.9 (ni)2.1 (t)6.9 (o)4 (r)8 ( pa)4 (t)7 (i)2 (e)8 (nt)7 (s)3 ( unt)7 (i)2 (l)2 ( s)3 (y)4 (m)17 (pt)7 (o)-6 (m)17 (s )-7 (c)8 (o)-6 (m)17 (pl)2 (e)8 (t)-3 (e)8 (l)2 (y)4 ( r)-2 (e)8 (s)3 (o)4 (l)2 (v)4 (e)8 (.)4 ( D)6 (i)1.9 (s)3.1 (c)8 (o)3.9 (nt)7 (i)2 (nue )]TJ ET Q BT 12 0 0 12 104.0288 438.1903 Tm [(H)-2 (E)-3 (R)2 (Z)7 (U)2 (M)4 (A)2 ( f)-7 (or)4 ( an)-4 (ap)-4 (h)-4 (yl)-2 (axi)-2 (s)-1 (, an)-4 (gi)-2 (oe)4 (d)-4 (e)4 (m)13 (a, i)-2 (n)-4 (t)3 (e)4 (r)-6 (s)-1 (t)3 (i)-2 (t)3 (i)-2 (al)-2 ( p)-4 (n)-4 (e)4 (u)-4 (m)13 (on)-4 (i)-2 (t)3 (i)-2 (s)-1 (, or)4 ( ac)4 (u)-4 (t)3 (e)4 ( r)4 (e)4 (s)-1 (p)-4 (i)-2 (r)4 (at)-7 (or)4 (y )]TJ -0.004 Tc 0.004 Tw T* [(d)-8 (i)-6 (s)-5 (t)-1 (res)-5 (s)-5 ( s)-5 (y)-4 (n)-8 (d)-8 (ro)-4 (m)9 (e )]TJ /TT2 1 Tf 0.001 Tc -0.001 Tw 7.94 0 Td [([)4 (se)5 (e )-5 (Wa)1 (rn)-2.9 (i)-1 (n)-3 (g)1 (s a)11 (n)-3 (d)1 ( P)2 (re)5 (c)5 (a)1 (u)-3 (t)-0.9 (i)-1 (o)11 (n)-3 (s \()]TJ 0 Tc 0 Tw 13.5 0 Td (5.2, 5.4)Tj -0.003 Tc 0.003 Tw (\)])Tj /TT1 1 Tf 0 Tc 0 Tw (. )Tj ET EMC BT /P <>BDC 12 0 0 12 104.0288 404.2303 Tm [(E)-3 (m)13 (b)-4 (r)4 (yo )-10 (F)1 (e)4 (t)3 (al)-2 ( T)-3 (oxi)-2 (c)4 (i)-2 (t)3 (y )]TJ EMC /P <>BDC 0 -1.67 TD [(E)-3 (xp)-4 (o)]TJ 0.004 Tc -0.004 Tw [(s)3 (ur)8 (e)8 ( t)7 (o)4 ( t)7 (r)8 (a)4 (s)3 (t)7 (uz)8 (u)-10 (m)7 (a)4 (b pr)8 (o)4 (duc)8 (t)7 (s)3 ( dur)8 (i)2 (ng )14 (pr)8 (e)8 (g)4 (na)4 (nc)8 (y)4 ( c)8 (a)4 (n r)8 (e)8 (s)3 (ul)2 (t)7 ( i)2 (n o)4 (l)2 (i)12 (g)4 (o)4 (hy)4 (dr)8 (a)4 (m)17 (ni)2 (o)4 (s)2.9 ( a)4 (nd )]TJ 0 Tc 0 Tw 0 -1.16 TD [(ol)-2 (i)-2 (goh)-4 (yd)-4 (r)4 (am)13 (n)-4 (i)-2 (os)-1 ( s)-1 (e)4 (q)-4 (u)-4 (e)4 (n)-4 (c)4 (e )-6 (m)13 (an)-4 (i)-2 (f)-7 (e)4 (s)-1 (t)3 (i)-2 (n)-4 (g as)-1 ( p)-4 (u)6 (l)8 (m)13 (on)-4 (ar)4 (y h)-4 (yp)-4 (op)-4 (l)-2 (as)-1 (i)-2 (a, s)-1 (k)-4 (e)4 (l)-2 (e)4 (t)3 (al)-2 ( ab)-4 (n)-4 (or)4 (m)13 (al)-2 (i)-2 (t)3 (i)-2 (e)4 (s)-1 (, )]TJ 0.004 Tc -0.004 Tw 0 -1.17 TD [(a)4 (nd ne)8 (o)4 (na)4 (t)7 (a)4 (l)2 ( de)8 (a)4 (t)7 (h.)4 ( A)6 (d)10 (v)4 (i)1.9 (s)3 (e)8 ( pa)4 (t)6.9 (i)2 (e)8 (nt)7 (s)3 ( o)4 (f)-3 ( t)7 (he)8 (s)3 (e)8 ( r)8 (i)2 (s)3 (ks)3 ( a)4 (nd t)7 (he)8 ( ne)8 (e)8 (d )10 (f)-3 (o)4 (r)8 ( e)8 (f)-3 (f)-3 (e)18 (c)8 (t)7 (i)2 (v)4 (e )]TJ -0.004 Tc 0.004 Tw T* [(co)-4 (n)-8 (t)-1 (ra)-4 (cep)-8 (t)-1 (i)-6 (o)]TJ 0.004 Tc -0.004 Tw 5.32 0 Td (n )Tj /TT2 1 Tf 0 Tc 0 Tw [([)3 (s)-1 (e)-6 (e)4 ( W)-1 (ar)-11 (n)-4 (i)-2 (n)-4 (gs)-1 ( an)-4 (d P)1 (r)-1 (e)4 (c)4 (au)-4 (t)-2 (i)-2 (o)10 (n)-4 (s)-1 ( \()13 (5.3\))3 ( an)-4 (d U)2 (s)-1 (e)4 ( i)-2 (n)-4 ( S)-4 (pe)4 (c)4 (i)-2 (f)3 (i)-2 (c )-6 (P)1 (opu)-4 (l)-2 (at)-2 (i)-2 (on)-4 (s)-1 ( \()3 (8.1, )]TJ -5.32 -1.17 Td (8.3)Tj -0.003 Tc 0.003 Tw (\)])Tj /TT1 1 Tf 0 Tc 0 Tw (. )Tj EMC /P <>BDC 14.04 0 0 14.04 98.3888 282.0704 Tm (1 )Tj -0.004 Tc 0.002 Tw 3.846 0 Td [(I)-8.2 (NDI)-8.2 (CAT)-3.7 (I)-8.1 (O)-3.8 (NS)-3.5 ( AND US)]TJ 0.004 Tw 10.692 0 Td [(AG)-3.7 (E )]TJ EMC /Span <>BDC -0.002 Tc 0.002 Tw -14.539 -2.009 Td [(1)-6.3 (.1 )]TJ EMC /Span <>BDC -0.004 Tc 3.846 0 Td [(Ad)-3.5 (j)-4.3 (u)-3.6 (v)-8.3 (an)-3.5 (t)-4.4 ( B)-3.7 (r)-4.4 (e)4.1 (a)-8.3 (st)-4.4 ( Can)-3.5 (c)-4.5 (e)-4.4 (r )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw 12 0 0 12 98.3888 233.5903 Tm [(H)2 (E)1 (R)-3 (Z)11 (U)2 (M)-1 (A)2 ( i)-2 (s)-1 ( i)-2 (ndi)-2 (c)-6 (a)4 (t)-2 (e)4 (d )-10 (f)3 (or)3 ( a)4 (dj)-2 (uva)4 (nt)-2 ( t)-2 (r)3 (e)-6 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( of )-7 (H)2 (E)1 (R)-3 (2 ove)4 (r)3 (e)4 (x)-10 (pr)3 (e)4 (s)-1 (s)-1 (i)-2 (ng)10 ( no)-10 (de)4 ( pos)-1 (i)-2 (t)-2 (i)-2 (ve)4 ( or)3 ( node )]TJ T* [(ne)4 (ga)4 (t)-2 (i)-2 (ve)4 ( \()3 (E)1 (R)-3 (/)-2 (P)-4 (R)-3 ( ne)4 (ga)4 (t)-2 (i)-2 (ve)4 ( or)3 ( w)2 (i)-2 (t)-2 (h one)4 ( hi)-12 (g)10 (h r)3 (i)-2 (s)-1 (k f)3 (e)-6 (a)4 (t)-2 (ur)3 (e )]TJ /TT4 1 Tf 0.002 Tc -0.002 Tw 22.23 0 Td [([)1 (s)1 (e)6 (e)6 ( C)-1 (lin)2 (ic)6 (a)2 (l S)2 (tu)2 (d)2 (ie)-4 (s)1 ( \()]TJ 0 Tc 0 Tw 8.86 0 Td (14.1)Tj -0.033 Tc 0.033 Tw 1.76 0 Td (\)])Tj /TT0 1 Tf -0.004 Tc 0.004 Tw 0.74 0 Td [(\))-1 ( b)-4 (r)-1 (eas)-5 (t )]TJ -33.59 -1.17 Td [(can)-4 (c)-10 (er )]TJ EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 0 Tw 3 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 1.5 0 Td [(as)-5 ( p)-4 (ar)-1 (t)-6 ( o)-4 (f)-1 ( a t)-16 (r)-1 (eat)-6 (m)-6 (en)-4 (t)-6 ( r)-11 (e)-10 (g)-4 (i)-6 (m)-5.9 (en )]TJ 0 Tc 0 Tw 12.22 0 Td [(c)4 (ons)-1 (i)-2 (s)-1 (t)-2 (i)-1.9 (ng)9.9 ( of)3 ( dox)-9.9 (or)2.9 (ubi)-1.9 (c)3.9 (i)-2 (n, c)-6 (y)20 (c)-5.9 (l)-2.1 (ophos)-0.9 (pha)3.9 (m)-2 (i)-1.9 (de)3.9 (, a)4 (nd )]TJ -0.004 Tc 0.004 Tw -12.22 -1.17 Td [(ei)-6 (t)-6 (h)-4 (er)-1 ( p)-4 (acl)-6 (i)-6 (t)-6 (ax)-14 (el)-6 ( o)-4 (r)-1 ( d)-4 (o)-4 (cet)-16 (ax)-14 (el )]TJ EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 0 Tw -1.5 -1.73 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 1.5 0 Td [(as)-5 ( p)-4 (ar)-1 (t)-6 ( o)-4 (f)-1 ( a t)-16 (r)-1 (eat)-6 (m)-6 (en)-4 (t)-6 ( r)-11 (e)-10 (g)-4 (i)-6 (m)-5.9 (en)-4.1 ( w)-1.9 (i)-6 (t)-6 (h)-4 ( d)-4 (o)-4 (cet)-6 (ax)-14 (el)-6 ( an)-4 (d)-4 ( car)-1 (b)-4 (o)-4 (p)-4 (l)-6 (at)-6 (i)-6 (n )]TJ EMC /P <>BDC -4.5 -1.65 Td [(S)-8 (el)-6 (ect)-6 ( p)-4 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( f)-1 (o)-4 (r)-1 ( t)-6 (h)-4 (e)-10 (r)-0.9 (ap)-14 (y )6 (b)-4 (as)-15 (ed)-4 ( o)-4 (n)-4 ( an )-14 (F)2 (D)-2 (A)]TJ 0 Tc 0 Tw 17.68 0 Td [(-)-7 (a)4 (ppr)-7 (ove)4 (d c)4 (om)-2 (pa)4 (ni)-2 (on di)-2 (a)-6 (g)10 (nos)-11 (t)-2 (i)-2 (c)4 ( f)3 (or)3 ( a)4 ( t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b )]TJ -17.68 -1.17 Td [(pr)3 (oduc)4 (t )]TJ /TT4 1 Tf 0.001 Tc -0.001 Tw 3.3 0 Td [([se)5 (e )]TJ 0 Tc 0 Tw 1.91 0 Td [(D)2 (os)-1 (ag)-10 (e)4 ( an)]TJ 0.002 Tc -0.002 Tw [(d)-8 ( A)3 (d)2 (m)4 (in)2 (is)1 (tr)1 (a)2 (tio)]TJ 0 Tc 0 Tw 10.58 0 Td [(n \()13 (2.1)]TJ -0.033 Tc 0.033 Tw 2.33 0 Td (\)])Tj /TT0 1 Tf 0 Tc 0 Tw 0.73 0 Td (. )Tj EMC /Artifact <>BDC 0.4 -4.6 Td (2)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 36.3888 32.3903 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4567 0 obj <>>>/Resources 4506 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4568 0 obj <> endobj 4569 0 obj <>stream /
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521.6214 137.4197 Tm ( )Tj /TT5 1 Tf -14 -0.837 Td ( )Tj /TT0 1 Tf 8.04 0 0 8.04 420.578 128.1797 Tm ( )Tj -6.656 -1.134 Td [( )-3735.3 ( )]TJ /TT4 1 Tf 11.04 0 0 11.04 339.4614 109.8197 Tm ( )Tj 15.076 0 Td ( )Tj /TT0 1 Tf 8.04 0 0 8.04 331.4214 100.5797 Tm ( )Tj /TT1 1 Tf -0.004 Tc 0.008 Tw 10.238 -1.134 Td ( )Tj /TT0 1 Tf 0 Tc 0 Tw -4.462 -1.149 Td ( )Tj /TT1 1 Tf -41.597 -2.284 Td ( )Tj ET Q 34.56 60.36 542.88 1.44 re f* EMC 1 0 0 1 -7.421356 0.580322 cm BT /P <>BDC /CS0 cs 0 scn /TT1 1 Tf -0.002 Tc 0.006 Tw 8.04 0 0 8.04 43.4214 747.8597 Tm [(HI)-1.1 (GHL)-6.7 (I)-1 (GH)14.8 (T)-6.7 (S)1.8 ( O)14.8 (F)-3 ( P)-2.9 (R)18.5 (E)-6.7 (S)1.8 (C)3.6 (R)3.6 (I)-1.1 (B)-6.6 (I)-1.1 (N)18.5 (G I)-1.1 (N)3.6 (F)-3 (OR)3.6 (M)1.7 (A)3.6 (T)-6.7 (I)-1 (ON )]TJ -0.004 Tc 0.008 Tw 0 -1.134 TD [(T)-8.6 (he)-7.7 (s)-3.1 (e)7.2 ( hi)5.3 (g)-11.4 (hl)5.4 (i)-9.6 (g)-11.4 (ht)0.7 (s)-3.1 ( d)14.7 (o)-11.5 ( n)14.7 (o)-11.5 (t)0.6 ( i)-9.6 (n)14.7 (c)-7.8 (l)-9.5 (ud)14.7 (e )7.5 (a)-11.5 (l)-9.6 (l)5.4 ( t)15.6 (he)-7.8 ( i)-9.6 (n)14.7 (f)0.6 (o)-11.4 (r)-7.8 (m)23 (a)-11.4 (t)0.6 (i)-9.6 (o)-11.4 (n n)14.7 (e)-7.8 (e)-7.7 (de)-7.7 (d)14.7 ( t)0.7 (o)-11.5 ( us)11.9 (e )]TJ -0.006 Tc 0.006 Tw 0 -1.149 TD [(H)-4.1 (E)-10.6 (RZ)4.3 (UM)-2.3 (A )]TJ 0.004 Tc -0.015 Tw 5.448 0 Td [(s)4.9 (a)11.5 (f)-6.3 (e)15.2 (l)-1.6 (y )-3.3 (a)-3.4 (n)7.7 (d)7.8 ( e)15.1 (f)-6.3 (f)8.7 (ect)8.7 (i)-1.6 (v)26.4 (el)13.4 (y)-3.5 (. S)7.7 (ee f)-6.3 (u)7.8 (l)13.3 (l )-16.3 (p)7.7 (r)15.2 (es)5 (c)15.1 (ri)-1.6 (b)22.7 (i)-1.6 (n)7.8 (g)-3.5 ( i)-1.6 (n)22.7 (f)-6.3 (o)11.5 (rm)31 (a)-3.4 (t)8.6 (i)-1.6 (o)-3.5 (n)7.8 ( f)8.6 (o)-3.4 (r )]TJ -0.006 Tc 0.006 Tw -5.448 -1.149 Td [(H)-4.1 (E)-10.6 (RZ)4.3 (UM)-2.3 (A)]TJ 0 Tc 0 Tw (. )Tj EMC /P <>BDC -0.006 Tc 0.006 Tw 0 -2.283 TD [(H)-4.1 (E)-10.6 (RZ)4.3 (UM)-2.3 (A)]TJ EMC /StyleSpan <>BDC 0 Tc 0 Tw 5.04 0 0 5.04 85.1814 704.8997 Tm (\256 )Tj EMC /P <>BDC -0.005 Tc 0.005 Tw 8.04 0 0 8.04 90.9436 701.8997 Tm [(\(tr)-8.8 (a)-12.5 (s)-4 (tu)-1.2 (z)-8.8 (u)-1.2 (m)22 (a)-12.5 (b)]TJ 0 Tc 0 Tw 5.746 0 Td (-)Tj -0.034 Tc 0.034 Tw 0.328 0 Td [(p)-45.2 (kr)-37.8 (b)]TJ 0.004 Tc -0.015 Tw 2.09 0 Td [(\) )-6.1 (f)-6.3 (o)-3.4 (r i)-1.6 (n)7.8 (j)8.6 (ect)23.5 (i)-1.5 (o)-3.5 (n)22.7 (, f)-6.3 (o)11.5 (r i)-1.5 (n)7.7 (t)8.6 (ra)-3.5 (v)11.5 (en)22.7 (o)-3.5 (u)7.8 (s )-9.8 (u)7.8 (s)19.8 (e )]TJ 0.006 Tc -0.002 Tw -14.074 -1.149 Td [(I)6.9 (n)9.8 (it)10.6 (i)0.5 (a)13.4 (l U)11.6 (.)2.3 (S)24.6 (.)2.3 ( A)11.5 (p)9.8 (p)9.7 (r)17.2 (o)-1.5 (v)13.5 (a)13.5 (l: )]TJ -0.007 Tc 0.007 Tw 9.493 0 Td [(2)0.5 (01)-14.5 (8 )]TJ EMC /P <>BDC /TT0 1 Tf 0.006 Tc -0.002 Tw -9.493 -2.283 Td [(H)11.6 (E)5 (R)1.4 (Z)20 (U)11.5 (MA)26.5 ( \()10.6 (t)0.5 (r)10.6 (a)2.2 (s)7 (tu)-1.5 (z)17.2 (u)13.4 (m)7.9 (a)17.2 (b)]TJ 0 Tc 0 Tw 10.373 0 Td (-)Tj -0.007 Tc 0.007 Tw 0.328 0 Td [(p)0.5 (k)-14.5 (r)-2.4 (b)]TJ 0.006 Tc -0.002 Tw 1.836 0 Td [(\) )25.8 (is )22.2 (b)-1.5 (i)15.4 (o)13.4 (s)6.9 (i)0.5 (m)7.8 (il)15.4 (a)2.2 (r)10.7 (*)13.4 ( to)13.5 ( H)11.6 (E)20 (R)1.3 (C)1.4 (E)5.1 (P)9.7 (T)5.1 (I)40.5 (N)11.5 ( \()10.6 (t)0.5 (r)10.6 (a)2.2 (s)7 (tu)-1.5 (z)17.2 (u)-1.5 (m)22.8 (a)2.3 (b)-1.5 (\))10.6 (. )]TJ EMC /Span <>BDC -0.005 Tc 0 Tw -12.537 -1.149 Td (\(1)Tj 0 Tc 0.836 0 Td (\) )Tj EMC ET /P <>BDC q 1 0 0 1 7.421356 -0.580322 cm 36.48 488.76 251.041 165.6 re W n 1 0 0 1 -7.421356 0.580322 cm BT /TT1 1 Tf -0.006 Tc 0.01 Tw 8.04 0 0 8.04 59.5014 646.2197 Tm [(W)8.9 (ARNI)-5.1 (NG)-4.1 (:)-1.4 ( CAR)-15.4 (DI)-5 (O)-4.2 (M)-2.2 (YO)-4.1 (P)-6.9 (AT)-10.7 (H)10.8 (Y,)-9.7 ( I)-5.1 (NF)-6.9 (US)-2.2 (I)-5 (O)-4.2 (N RE)-10.7 (ACT)4.3 (I)-5.1 (O)-4.1 (NS)-2.2 (, )]TJ ET EMC Q BT /P <>BDC /TT1 1 Tf -0.006 Tc 0.006 Tw 8.04 0 0 8.04 58.4214 636.9797 Tm [(E)-10.6 (M)-2.3 (B)-10.7 (RYO)]TJ 0 Tc 0 Tw 4.493 0 Td (-)Tj -0.006 Tc 0.01 Tw 0.328 0 Td [(F)8 (E)-10.6 (T)-10.7 (AL)4.3 ( T)-10.6 (O)-4.1 (X)14.5 (I)-5 (CI)-5 (T)-10.7 (Y, )5.5 (a)-13.5 (n)12.7 (d)-2.2 ( P)-6.9 (UL)-10.6 (M)-2.3 (O)-4.1 (NARY )]TJ -0.001 Tc 0.001 Tw [(T)9.2 (O)0.9 (X)19.5 (IC)4.6 (IT)-5.6 (Y )]TJ EMC /P <>BDC /TT2 1 Tf 0.008 Tc -0.019 Tw -3.463 -1.134 Td [(S)11.8 (e)4.2 (e )-10.5 (f)12.6 (u)11.8 (l)17.3 (l)2.4 ( p)0.6 (r)8.9 (e)4.2 (s)23.9 (c)4.2 (r)9 (i)17.3 (b)0.5 (i)2.5 (n)26.6 (g)0.6 ( i)2.4 (n)11.7 (f)12.7 (o)0.5 (r)23.9 (m)-5.1 (a)15.5 (t)17.3 (i)17.4 (o)0.5 (n )-3 (f)12.6 (o)0.6 (r)23.8 ( c)4.3 (o)15.4 (m)-5 (p)15.4 (l)17.4 (e)4.2 (t)17.3 (e)4.3 ( b)0.5 (o)15.5 (x)0.5 (e)19.2 (d)0.5 ( w)18.3 (a)0.5 (r)8.9 (n)11.8 (i)2.4 (n)26.7 (g )]TJ EMC /P <>BDC /TT1 1 Tf -0.004 Tc 0.008 Tw -2.522 -2.298 Td [(C)1.6 (a)-11.5 (r)-7.7 (di)5.4 (o)-11.5 (m)23.1 (y)-11.5 (o)-11.5 (pa)-11.5 (t)0.7 (h)14.7 (y)-11.5 (:)0.6 ( T)6.3 (r)-7.8 (a)3.5 (s)-3.1 (t)0.7 (uz)-7.7 (um)23 (a)-11.5 (b pr)-7.7 (o)-11.5 (duc)-7.7 (t)0.6 (s )12.2 (c)-7.8 (a)-11.5 (n )15.2 (r)-7.8 (e)-7.7 (s)-3.1 (u)14.7 (l)-9.6 (t)0.7 ( i)-9.6 (n)14.7 ( s)-3.1 (ubc)-7.8 (l)5.4 (i)-9.6 (ni)5.4 (c)-7.8 (a)3.5 (l )5.6 (a)-11.5 (nd )]TJ 0.004 Tc 0 Tw 0 -1.134 TD [(cl)-1.5 (i)-1.6 (n)22.6 (i)-1.5 (c)15.1 (a)-3.4 (l)13.3 ( c)15.1 (a)-3.4 (rd)22.7 (i)-1.6 (a)11.5 (c )15.2 (f)-6.3 (a)11.5 (i)-1.6 (l)-1.6 (u)22.7 (re m)31 (a)-3.4 (n)7.7 (i)13.4 (f)-6.3 (es)5 (t)8.6 (i)-1.6 (n)22.7 (g )11.7 (a)-3.4 (s)4.9 ( C)9.6 (H)5.8 (F)18 (, )15.2 (a)-3.5 (n)7.8 (d)7.7 ( d)7.8 (e)15.1 (cre)15.1 (a)-3.4 (s)4.9 (ed)22.7 ( L)-0.6 (V)24.5 (E)-0.7 (F)3.1 (, )]TJ -0.004 Tc 0.008 Tw 0 -1.149 TD [(w)-13.3 (i)-9.6 (t)0.6 (h )15.2 (g)-11.5 (r)7.2 (e)7.1 (a)-11.4 (t)0.6 (e)-7.7 (s)-3.1 (t)0.7 ( r)7.2 (i)-9.6 (s)-3 (k)29.6 ( w)-13.3 (he)-7.7 (n a)-11.4 (dm)23.1 (i)-9.6 (ni)-9.6 (s)-3.1 (t)0.7 (e)-7.8 (r)7.2 (e)7.1 (d c)-7.8 (o)-11.5 (n)14.7 (c)-7.7 (ur)-7.7 (r)7.1 (e)-7.7 (nt)0.7 (l)5.3 (y )3.8 (w)-13.4 (i)-9.6 (t)0.7 (h )]TJ 0.004 Tc 0 Tw T* [(a)-3.5 (n)7.8 (t)8.6 (h)7.8 (ra)11.5 (cy)11.5 (cl)13.4 (i)-1.6 (n)7.7 (es)19.8 (. E)-0.7 (v)26.4 (a)-3.4 (l)-1.6 (u)22.6 (a)-3.4 (t)8.6 (e )15.2 (ca)11.4 (rd)7.7 (i)13.4 (a)-3.5 (c)15.2 ( f)-6.2 (u)22.6 (n)7.8 (ct)8.7 (i)-1.6 (o)-3.5 (n)22.7 ( p)7.8 (ri)13.3 (o)-3.5 (r)15.2 ( t)8.6 (o)11.5 ( a)-3.5 (n)7.7 (d)7.8 ( d)7.7 (u)22.7 (ri)-1.6 (n)22.6 (g )]TJ 0.008 Tc -0.004 Tw 0 -1.134 TD [(t)12.6 (r)4.3 (e)4.2 (a)0.5 (t)12.7 (m)35 (e)4.2 (n)11.8 (t)12.6 (.)4.3 ( D)13.6 (i)2.4 (s)9 (c)19.2 (o)0.5 (n)11.7 (t)12.7 (i)2.4 (n)11.7 (u)11.8 (e)19.2 ( H)9.9 (E)3.3 (R)13.6 (Z)18.3 (U)13.6 (M)11.7 (A)13.6 ( f)12.7 (o)0.5 (r)19.2 ( c)19.2 (a)0.5 (r)4.2 (d)11.8 (i)17.3 (o)0.6 (m)35 (y)0.5 (o)0.6 (p)11.7 (a)0.6 (t)12.6 (h)26.7 (y)0.5 (.)4.3 ( \()27.5 (2)0.6 (.)19.1 (3)0.6 (,)19.1 ( 5)15.5 (.)4.2 (1)]TJ 0 Tc 0 Tw 27.746 0 Td (\) )Tj EMC /P <>BDC 0.008 Tc -0.004 Tw -27.747 -2.298 Td [(I)8.9 (n)11.8 (f)-2.3 (u)11.8 (s)8.9 (i)17.3 (o)0.6 (n)11.7 ( R)13.6 (e)19.1 (a)0.6 (c)4.2 (t)27.6 (i)2.4 (o)0.5 (n)11.8 (s)23.8 (,)4.3 ( P)7 (u)26.7 (l)2.4 (m)35 (o)0.6 (n)11.7 (a)0.5 (r)4.3 (y)15.4 ( T)18.3 (o)0.5 (x)30.4 (i)2.4 (c)4.3 (i)2.4 (t)27.5 (y)0.6 (:)12.6 ( D)13.5 (i)2.4 (s)23.9 (c)4.3 (o)0.5 (n)11.7 (t)27.6 (i)2.4 (n)11.8 (u)11.7 (e)4.3 ( H)24.8 (E)3.4 (R)13.6 (Z)18.2 (U)13.6 (M)11.7 (A)13.6 ( f)12.6 (o)0.5 (r )]TJ T* [(a)0.5 (n)11.8 (a)0.5 (p)11.8 (h)26.7 (y)0.5 (l)17.3 (a)0.6 (x)15.4 (i)2.4 (s)9 (,)19.2 ( a)0.6 (n)26.6 (g)0.6 (i)17.3 (o)15.5 (e)4.2 (d)11.8 (e)4.2 (m)35 (a)0.6 (,)4.2 ( i)2.4 (n)11.8 (t)12.6 (e)19.2 (r)4.2 (s)8.9 (t)12.7 (i)2.4 (t)12.6 (i)17.4 (a)0.5 (l)2.4 ( p)11.7 (n)26.7 (e)4.2 (u)11.8 (m)35 (o)0.6 (n)11.7 (i)2.4 (t)12.7 (i)2.4 (s)8.9 (, )19.5 (o)0.5 (r)19.2 ( a)15.5 (c)4.2 (u)11.8 (t)12.6 (e )]TJ 0.004 Tc 0 -1.149 TD [(res)4.9 (p)7.8 (i)13.3 (r)]TJ 0 Tw [(a)-3.5 (t)23.5 (o)-3.4 (r)15.1 (y)-3.4 ( d)22.7 (i)-1.6 (s)5 (t)8.6 (res)4.9 (s)19.9 ( s)4.9 (y)-3.5 (n)7.8 (d)22.7 (ro)-3.5 (m)31.1 (e. \()]TJ -0.011 Tc 0.015 Tw 13.552 0 Td [(5)-3.5 (.)-14.8 (2)-3.5 (, 5)-18.4 (.4)]TJ 0 Tc 0 Tw 2.985 0 Td (\) )Tj EMC ET /P <>BDC BT -0.027 Tc 0.027 Tw 8.04 0 0 8.04 49.0614 517.4597 Tm [(E)-31.6 (mb)-23.2 (r)-30.8 (y)-34.4 (o)]TJ 0 Tc 0 Tw 3.493 0 Td (-)Tj -0.004 Tc 0.008 Tw 0.328 0 Td [(F)-4.9 (e)-7.8 (t)15.6 (a)-11.5 (l )5.6 (T)6.3 (o)-11.4 (x)3.4 (i)-9.6 (c)7.2 (i)-9.6 (t)0.7 (y)-11.5 (: )15.8 (E)-8.6 (x)3.5 (po)-11.4 (s)-3.1 (ur)7.1 (e)-7.7 ( t)15.5 (o)-11.4 ( t)0.7 (r)7.1 (a)-11.4 (s)-3.1 (t)0.7 (uz)-7.7 (um)23.1 (a)-11.5 (b pr)-7.8 (o)-11.4 (du)14.7 (c)-7.7 (t)0.6 (s)-3.1 ( dur)-7.7 (i)-9.6 (n)14.7 (g )]TJ 0.004 Tc 0 Tw -3.821 -1.149 Td [(p)7.8 (reg)-3.4 (n)22.7 (a)-3.5 (n)7.7 (c)15.2 (y )11.7 (ca)-3.5 (n)22.7 ( re)15.2 (s)4.9 (u)7.7 (l)-1.5 (t )23.8 (i)-1.6 (n)7.8 ( o)11.5 (l)-1.6 (i)13.4 (g)11.4 (o)-3.4 (h)7.7 (y)-3.5 (d)22.7 (ra)11.4 (m)16.1 (n)7.8 (i)-1.6 (o)-3.5 (s)5 (, )15.2 (i)-1.5 (n)7.7 ( s)19.8 (o)-3.4 (m)31 (e ca)-3.4 (s)4.9 (es)19.8 ( c)15.1 (o)-3.4 (m)31 (p)7.8 (l)-1.6 (i)-1.6 (ca)-3.4 (t)8.6 (ed )]TJ -0.004 Tc 0.008 Tw T* [(by)-11.5 ( pul)-9.6 (m)23.1 (o)-11.5 (na)-11.5 (r)7.2 (y)-11.5 ( h)14.6 (y)-11.4 (p)14.7 (o)-11.5 (pl)5.3 (a)-11.4 (s)-3.1 (i)5.4 (a )3.7 (a)-11.5 (nd ne)7.1 (o)-11.4 (n)14.7 (a)-11.5 (t)0.7 (a)3.4 (l)-9.6 ( de)7.1 (a)-11.4 (t)0.6 (h.)-7.7 ( A)1.6 (dv)3.4 (i)-9.5 (s)11.8 (e)-7.7 ( p)14.7 (a)-11.4 (t)0.6 (i)-9.6 (e)-7.7 (nt)0.7 (s )12.1 (o)3.5 (f)-14.3 ( t)0.6 (he)-7.8 (s)11.9 (e )]TJ ET q 1 0 0 1 7.421356 -0.580322 cm 36.48 488.76 251.041 165.6 re W n 1 0 0 1 -7.421356 0.580322 cm BT 8.04 0 0 8.04 49.0614 489.8597 Tm [(r)-7.8 (i)-9.5 (s)-3.1 (k)29.6 (s)-3 ( a)-11.4 (nd t)0.6 (he)-7.8 ( ne)-7.7 (e)-7.8 (d)14.7 ( f)]TJ ET Q q 1 0 0 1 7.421356 -0.580322 cm 36.48 488.76 251.041 165.6 re W n 1 0 0 1 -7.421356 0.580322 cm BT 0.004 Tc 0 Tw 8.04 0 0 8.04 115.7814 489.8597 Tm [(o)-3.5 (r)15.2 ( e)15.1 (f)8.7 (f)-6.3 (e)15.1 (ct)8.6 (i)-1.6 (v)11.5 (e )15.2 (co)-3.5 (n)7.7 (t)23.6 (ra)-3.5 (c)15.2 (ep)7.7 (t)8.7 (i)13.3 (o)-3.4 (n)7.7 (. \()]TJ ET Q q 1 0 0 1 7.421356 -0.580322 cm 36.48 488.76 251.041 165.6 re W n 1 0 0 1 -7.421356 0.580322 cm BT 0.008 Tc -0.019 Tw 8.04 0 0 8.04 209.5014 489.8597 Tm [(5)0.5 (.)19.2 (3)0.6 (,)4.2 ( 8)0.6 (.)19.1 (1)0.6 (, )4.4 (8)15.5 (.)4.2 (3)]TJ ET Q q 1 0 0 1 7.421356 -0.580322 cm 36.48 488.76 251.041 165.6 re W n 1 0 0 1 -7.421356 0.580322 cm BT 0 Tc 0 Tw 8.04 0 0 8.04 247.6614 489.8597 Tm (\) )Tj ET EMC Q BT /P <>BDC -0.006 Tc 0.01 Tw 8.04 0 0 8.04 117.9442 470.8937 Tm [(I)-5.1 (NDI)-5 (CAT)-10.6 (I)-5.1 (O)-4.1 (NS)-2.2 ( AND US)-2.2 (AG)]TJ 0 Tc 0 Tw 12.164 0 Td (E )Tj EMC /P <>BDC /TT0 1 Tf 0.008 Tc -0.004 Tw -21.433 -1.134 Td [(H)13.6 (E)7 (R)3.4 (Z)22 (U)13.5 (M)1.5 (A)28.5 ( i)2.4 (s)8.9 ( a)4.2 ( H)13.6 (E)22 (R)18.3 (2)0.5 (/)17.3 (n)0.5 (e)19.2 (u)0.5 ( r)12.7 (e)19.1 (c)4.2 (e)19.2 (p)0.5 (t)2.4 (o)15.5 (r )27.8 (a)19.2 (n)0.5 (t)17.4 (a)4.2 (g)15.4 (o)15.5 (n)0.5 (i)2.5 (s)23.8 (t)2.4 ( i)17.3 (n)15.5 (d)0.5 (i)17.4 (c)4.2 (a)4.2 (t)2.5 (e)34 (d)0.6 ( f)12.7 (o)15.4 (r)12.7 (: )]TJ EMC /Span <>BDC /C2_1 1 Tf 0 Tc 0 Tw 0 -1.209 TD <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /Span <>BDC /TT0 1 Tf -0.011 Tc 0.015 Tw 1.12 0 Td [(t)-16.6 (h)-18.5 (e t)-16.6 (r)-6.4 (ea)-14.8 (t)-1.6 (m)-9.1 (en)-18.5 (t)-16.5 ( o)-3.5 (f)-6.4 ( H)-5.4 (E)3 (R)-0.8 (2)]TJ 0 Tc 0 Tw 9.045 0 Td (-)Tj -0.011 Tc 0.328 0 Td [(o)-3.5 (v)-3.6 (er)-21.3 (ex)-3.6 (p)-18.4 (r)-6.4 (es)-10.1 (s)-10.1 (i)-16.5 (n)-18.5 (g )-18.3 (b)-18.4 (r)-6.4 (ea)-14.8 (s)-10.1 (t)-16.5 ( c)-14.8 (an)-18.4 (c)-14.8 (er)-6.4 (. )-29.4 (\()-6.4 (1)-3.5 (.)-14.8 (1)-3.5 (,)-14.8 ( 1)-18.4 (.2)]TJ 0 Tc 15.313 0 Td (\) )Tj EMC /P <>BDC -0.011 Tc 0.015 Tw -25.806 -2.298 Td [(S)-7.2 (el)-16.6 (ec)-14.8 (t)-16.6 ( p)-3.5 (a)-14.8 (t)-16.6 (i)-16.5 (e)15 (n)-18.4 (t)-16.6 (s)-10.1 ( f)-6.4 (o)-3.5 (r)-6.4 ( t)-1.7 (h)-18.4 (er)-6.3 (a)-14.8 (p)-18.4 (y)11.4 ( b)-18.5 (as)-10 (ed)-18.5 ( o)-3.5 (n)-3.6 ( an)-18.5 ( F)7.6 (D)-5.4 (A)]TJ 0 Tc 0 Tw 17.597 0 Td (-)Tj -0.007 Tc 0.011 Tw 0.328 0 Td [(a)-10.8 (p)-14.4 (p)-14.5 (r)-2.4 (o)0.5 (v)0.5 (e)4.1 (d)-14.4 ( c)-10.8 (o)0.5 (m)9.8 (p)-14.5 (a)4.2 (n)-14.5 (i)-12.6 (o)0.5 (n )]TJ 0.007 Tw 8.642 0 Td [(d)0.5 (i)-12.6 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(r)-6.4 (ee )-14.6 (w)9.5 (e)-14.8 (ek)-18.5 (s)-10 ( t)-16.6 (o)-3.5 ( c)-14.8 (o)-3.5 (m)5.8 (p)-18.5 (l)-1.6 (et)-16.6 (e a)-14.8 ( t)-16.6 (o)-3.6 (t)-1.6 (a)-14.8 (l)-1.6 ( o)-3.5 (f)-6.4 ( 5)-18.5 (2)-3.5 ( w)9.5 (e)-14.8 (ek)-18.5 (s)-10.1 ( o)-3.5 (f)-6.4 ( t)-16.6 (h)]TJ 0.011 Tw 25.388 0 Td [(er)-6.4 (ap)-18.5 (y)]TJ 0 Tc 0 Tw 2.179 0 Td (. )Tj EMC /P <>BDC /TT1 1 Tf -0.005 Tc -0.006 Tw -28.686 -2.283 Td [(M)-1.3 (e)-8.8 (ta)-12.5 (s)-4.1 (ta)-12.5 (t)14.6 (i)-10.6 (c)-8.8 ( H)-3.1 (E)-9.7 (R)15.5 (2)]TJ 0 Tc 0 Tw 7.388 0 Td (-)Tj 0.004 Tc 0.328 0 Td [(O)5.9 (v)11.4 (erex)11.5 (p)7.8 (r)15.1 (es)4.9 (s)4.9 (i)-1.5 (n)22.6 (g )11.8 (B)14.2 (rea)11.5 (s)4.9 (t)8.7 ( C)9.6 (a)-3.5 (n)22.7 (cer)15.2 ( \()8.7 (2)-3.5 (.)15.2 (2)]TJ 0 Tc 14.821 0 Td (\) )Tj EMC /Span <>BDC /C2_1 1 Tf -22.538 -1.209 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /Span <>BDC /TT0 1 Tf 0.008 Tc -0.004 Tw 1.12 0 Td [(I)27.6 (n)0.5 (i)2.4 (t)2.4 (i)2.4 (a)4.3 (l )32.5 (d)0.5 (o)15.5 (s)8.9 (e)19.2 ( o)15.4 (f)12.7 ( 4)0.6 ( m)9.9 (g)15.4 (/)17.4 (k)0.5 (g)15.5 ( a)4.3 (s)23.8 ( a )19.4 (9)15.5 (0)0.5 ( m)24.8 (i)2.4 (n)15.5 (u)15.4 (t)2.4 (e )4.5 (I)42.5 (V)13.6 ( i)2.4 (n)0.5 (f)12.7 (u)0.5 (s)8.9 (i)2.4 (o)30.4 (n)0.6 ( f)12.7 (o)15.4 (l)17.4 (l)17.3 (o)0.5 (w)13.6 (e)19.2 (d)0.5 ( b)0.5 (y)30.4 ( s)9 (u)0.5 (b)15.5 (s)8.9 (e)19.2 (q)0.5 (u)0.5 (e)19.2 (n)15.5 (t )]TJ 0 -1.164 TD [(w)13.6 (e)19.1 (e)19.2 (k)0.5 (l)2.4 (y)30.4 ( d)0.5 (o)15.5 (s)8.9 (e)19.2 (s)8.9 ( o)0.5 (f)12.6 ( 2)0.5 ( m)9.9 (g)15.4 (/)17.4 (k)0.5 (g)15.5 ( a)4.2 (s)23.8 ( 3)15.5 (0)0.5 ( m)24.8 (i)2.4 (n)15.4 (u)15.5 (t)17.3 (e )4.5 (I)27.6 (V)13.6 ( i)2.5 (n)0.5 (f)12.6 (u)0.6 (s)23.8 (i)2.4 (o)15.5 (n)0.5 (s)23.9 (. )]TJ EMC /P <>BDC /TT1 1 Tf -0.006 Tc 0.01 Tw 6.164 -2.284 Td [(DO)-4.1 (S)-2.3 (AG)-4.1 (E)-10.6 ( F)-6.9 (O)-4.1 (RM)-2.3 (S)-2.3 ( AND S)12.7 (T)-10.6 (R)]TJ 0.005 Tc -0.005 Tw [(EN)10.6 (G)21.8 (TH)6.9 (S)]TJ EMC /Span <>BDC /C2_1 1 Tf 0 Tc 0 Tw -7.283 -1.209 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj 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(y)30.4 ( m)9.9 (e)19.2 (a)4.2 (n)0.5 (i)17.4 (n)0.5 (g)15.5 (f)12.6 (u)0.6 (l )]TJ T* [(d)0.5 (i)2.5 (f)12.6 (f)12.6 (e)19.2 (r)12.6 (e)19.2 (n)0.5 (c)4.2 (e)19.2 (s)8.9 ( b)0.5 (e)19.2 (t)2.4 (w)28.5 (e)4.3 (e)19.1 (n)0.5 ( t)17.4 (h)0.5 (e)19.1 ( b)0.6 (i)2.4 (o)15.4 (s)23.9 (i)2.4 (m)9.9 (i)2.4 (l)17.3 (a)4.3 (r )27.8 (p)0.5 (r)27.6 (o)15.4 (d)0.6 (u)0.5 (c)19.2 (t )17.6 (a)4.2 (n)15.5 (d )15.7 (t)2.4 (h)0.5 (e)19.2 ( r)12.6 (e)19.1 (f)12.7 (e)19.1 (r)12.7 (e)19.1 (n)0.6 (c)4.2 (e)19.2 ( p)0.5 (r)12.6 (o)15.5 (d)0.5 (u)0.5 (c)19.2 (t)2.4 (. )]TJ 0.006 Tc -0.002 Tw 0 -1.149 TD [(B)1.4 (io)13.4 (s)7 (im)22.8 (il)15.3 (a)2.3 (r)10.6 (ity)28.4 ( o)13.4 (f)10.7 ( H)11.5 (E)5.1 (R)1.3 (Z)20 (U)11.6 (MA)26.5 ( h)-1.4 (a)2.2 (s )22.2 (b)-1.5 (e)17.2 (e)17.1 (n)13.5 ( d)-1.4 (e)17.1 (m)7.9 (o)13.5 (n)-1.5 (s)6.9 (t)0.5 (r)25.5 (a)2.3 (te)17.1 (d)-1.4 ( f)10.7 (o)13.4 (r )25.9 (th)-1.5 (e)17.2 ( c)2.3 (o)28.3 (n)-1.4 (d)13.4 (i)0.5 (t)15.3 (io)13.5 (n)-1.5 (\()10.6 (s)7 (\))10.6 ( o)13.5 (f 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Tw 24.179 -2.298 Td [(R)9.6 (ev)11.5 (i)-1.6 (s)4.9 (ed)7.7 (: )]TJ 0.008 Tc -0.008 Tw 3.896 0 Td [(1)0.5 (2)]TJ 0 Tc 0 Tw 1 0 Td (/)Tj -0.007 Tc 0.007 Tw 0.284 0 Td [(2)0.5 (01)-14.5 (8 )]TJ EMC /P <>BDC -0.006 Tc 0.01 Tw -65.184 -3.35 Td [(F)-6.9 (UL)-10.6 (L)4.3 ( P)-7 (RE)-10.6 (S)-2.3 (CRI)-5 (B)-10.7 (I)-5 (NG)10.8 ( I)-5 (NF)-6.9 (O)-4.1 (RM)-2.3 (A)14.5 (T)-10.6 (I)-5.1 (O)-4.1 (N:)-1.4 ( CO)-4.2 (NT)4.3 (E)-10.6 (NT)-10.7 (S)12.7 (* )]TJ EMC /Link <>BDC 0 -2.283 TD [(W)8.9 (ARNI)-5.1 (NG)-4.1 (:)-1.4 ( CAR)-15.4 (DI)-5 (O)-4.2 (M)-2.2 (YO)-4.1 (P)-6.9 (AT)-10.7 (H)10.8 (Y,)-9.7 ( I)-5.1 (NF)-6.9 (US)-2.2 (I)-5 (O)-4.2 (N RE)-10.7 (ACT)4.3 (I)]TJ 0.006 Tw 25.045 0 Td [(O)-4.1 (NS)-2.3 (, )]TJ EMC /Link <>BDC -25.045 -1.149 Td [(E)-10.6 (M)-2.3 (B)-10.7 (RYO)]TJ 0 Tc 0 Tw 4.493 0 Td (-)Tj 0.005 Tc -0.001 Tw 0.328 0 Td [(F)19 (ETA)10.6 (L)15.3 ( TO)6.9 (X)25.5 (I)6 (C)10.6 (I)5.9 (T)]TJ -0.006 Tc 0.01 Tw [(Y,)-9.8 ( A)14.5 (ND P)-6.9 (UL)-10.7 (M)-2.2 (O)-4.2 (NARY T)-10.7 (O)-4.1 (X)]TJ -0.001 Tc 0.001 Tw 20.478 0 Td [(IC)4.6 (IT)-5.6 (Y )]TJ EMC /Link <>BDC 0 Tc 0 Tw -25.299 -1.15 Td (1 )Tj -0.006 Tc 0.01 Tw 2.687 0 Td [(I)-5.1 (NDI)-5 (CAT)-10.6 (I)-5.1 (O)-4.1 (NS)-2.2 ( AND US)-2.2 (AG)]TJ 0 Tc 0 Tw 12.164 0 Td (E )Tj EMC /Span <>BDC /TT0 1 Tf -0.011 Tc -12.164 -1.134 Td [(1)-18.5 (.1 )]TJ EMC /Span <>BDC -0.007 Tc -0.004 Tw 2.687 0 Td [(A)13.5 (d)-14.5 (j)-12.6 (u)-14.4 (va)-10.7 (nt)-12.5 ( B)-11.6 (r)-2.4 (e)]TJ -0.011 Tc 0 Tw 5.388 0 Td [(a)-14.8 (s)-10 (t)-16.6 ( C)-15.7 (an)-18.5 (c)-14.7 (er )]TJ EMC /Span <>BDC -8.075 -1.149 Td [(1)-18.5 (.2 )]TJ EMC /Span <>BDC 0.004 Tc 2.687 0 Td [(M)-2.5 (e)15.1 (t)-1.5 (as)19.8 (t)-1.5 (at)13.3 (i)-1.5 (c)15.1 ( B)-0.7 (r)8.7 (e)15.2 (as)4.9 (t)13.4 ( C)14.3 (an)11.5 (ce)15.2 (r )]TJ EMC /Link <>BDC /TT1 1 Tf 0 Tc -5.373 -1.149 Td (2 )Tj -0.006 Tc 0.01 Tw 2.687 0 Td [(DO)-4.1 (S)-2.3 (AG)-4.1 (E)-10.6 ( AND ADM)-2.3 (I)-5 (NI)-5.1 (S)-2.2 (T)-10.7 (R)]TJ -0.017 Tc 0.017 Tw [(A)-11.4 (T)-21.6 (I)-16.1 (ON )]TJ EMC /Span <>BDC /TT0 1 Tf -0.011 Tc 0 Tw 0 -1.134 TD [(2)-18.5 (.1 )]TJ EMC /Span <>BDC 0.006 Tc -0.002 Tw 2.687 0 Td [(P)9.8 (a)2.2 (tie)17.2 (n)13.4 (t)0.5 ( S)9.8 (e)17.1 (l)15.4 (e)17.1 (c)2.3 (tio)13.5 (n )]TJ EMC /Span <>BDC -0.011 Tc 0 Tw -2.687 -1.149 Td [(2)-18.5 (.2 )]TJ EMC /Span <>BDC 0.015 Tw 2.687 0 Td [(R)-15.6 (ec)-14.7 (o)-3.6 (m)-9.1 (m)-9.1 (en)-18.4 (d)-18.5 (ed)-18.5 ( D)-5.4 (o)-3.6 (s)-10 (es)-10 ( an)-3.6 (d)-18.4 ( S)-7.3 (ch)-18.5 (ed)-3.6 (u)-18.4 (l)-1.7 (e)]TJ 0 Tc 0 Tw (s )Tj EMC /Span <>BDC -0.011 Tc -2.687 -1.149 Td [(2)-18.5 (.3 )]TJ EMC /Span <>BDC 0.008 Tc -0.019 Tw 2.687 0 Td [(I)27.6 (m)9.8 (p)0.6 (o)15.4 (r)12.7 (t)2.4 (a)4.2 (n)0.5 (t )-12.3 (D)13.6 (o)15.5 (s)8.9 (i)17.3 (n)0.6 (g)15.4 ( C)3.4 (o)15.4 (n)0.6 (s)23.8 (i)2.4 (d)0.6 (e)19.1 (r)12.7 (a)4.2 (t)17.3 (i)2.5 (o)15.4 (n)0.6 (s )]TJ EMC /Link <>BDC -0.011 Tc 0 Tw -2.687 -1.134 Td [(2)-18.5 (.4 )]TJ 0.006 Tc -0.002 Tw 2.687 0 Td [(P)9.8 (r)10.6 (e)17.2 (p)-1.5 (a)2.2 (r)10.7 (a)2.2 (tio)28.4 (n)-1.5 ( f)10.7 (o)13.4 (r)10.7 ( A)26.5 (d)-1.5 (m)7.9 (i)0.5 (n)13.4 (is)7 (tr)25.5 (a)2.3 (t)15.3 (io)13.5 (n )]TJ EMC /Link <>BDC /TT1 1 Tf 0 Tc 0 Tw -5.373 -1.149 Td (3 )Tj -0.006 Tc 0.01 Tw 2.687 0 Td [(DO)-4.1 (S)-2.3 (AG)-4.1 (E)-10.6 ( F)-6.9 (O)-4.1 (RM)-2.3 (S)-2.3 ( AND S)12.7 (T)-10.6 (R)]TJ 0.005 Tc -0.005 Tw [(EN)10.6 (G)21.8 (TH)6.9 (S )]TJ EMC /Link <>BDC 0 Tc 0 Tw -2.687 -1.134 Td (4 )Tj -0.006 Tc 2.687 0 Td [(CO)-4.1 (NT)-10.7 (RAI)-5.1 (NDI)-5.1 (CAT)-10.6 (I)-5.1 (O)-4.1 (NS )]TJ EMC /Link <>BDC 0 Tc -2.687 -1.149 Td (5 )Tj -0.006 Tc 0.01 Tw 2.687 0 Td [(W)8.9 (ARNI)-5.1 (NG)-4.1 (S)-2.2 ( AND P)-7 (RE)-10.6 (CAUT)]TJ 0.006 Tw 13.045 0 Td [(I)-5.1 (O)-4.1 (NS )]TJ EMC /Span <>BDC /TT0 1 Tf -0.011 Tc 0 Tw -13.045 -1.149 Td [(5)-18.5 (.1 )]TJ EMC /Span <>BDC -0.007 Tc 2.687 0 Td [(C)-11.6 (a)-10.8 (r)-2.4 (d)0.5 (i)-12.6 (o)0.5 (m)-5.2 (y)15.4 (o)0.5 (p)-14.5 (a)-10.7 (t)-12.6 (h)-14.5 (y )]TJ EMC /Span <>BDC -0.011 Tc -2.687 -1.134 Td [(5)-18.5 (.2 )]TJ EMC /Span <>BDC 0.008 Tc -0.019 Tw 2.687 0 Td [(I)27.6 (n)0.5 (f)12.6 (u)0.6 (s)8.9 (i)2.4 (o)15.5 (n)0.5 ( R)3.4 (e)19.1 (a)4.2 (c)4.3 (t)17.3 (i)2.4 (o)15.5 (n)0.5 (s )]TJ EMC /Span <>BDC -0.011 Tc 0 Tw -2.687 -1.149 Td [(5)-18.5 (.3 )]TJ EMC /Span <>BDC -0.022 Tc 0.022 Tw 2.687 0 Td [(E)-22.9 (m)-20.2 (b)-29.4 (r)-17.4 (yo)]TJ 0 Tc 0 Tw 3.194 0 Td (-)Tj 0.006 Tc -0.002 Tw 0.343 0 Td [(F)9.8 (e)17.1 (ta)2.3 (l)15.3 ( T)20 (o)13.4 (x)13.5 (ic)2.2 (ity )]TJ EMC /Span <>BDC -0.011 Tc 0 Tw -6.224 -1.149 Td [(5)-18.5 (.4 )]TJ EMC /Span <>BDC 0.006 Tc -0.002 Tw 2.687 0 Td [(P)9.8 (u)-1.5 (l)15.3 (m)7.9 (o)13.5 (n)-1.5 (a)2.2 (r)10.7 (y)28.4 ( T)20 (o)-1.5 (x)13.5 (ic)2.3 (ity )]TJ EMC /Span <>BDC -0.011 Tc 0.011 Tw -2.687 -1.134 Td [(5)-18.5 (.5 )]TJ EMC /Span <>BDC -0.007 Tc 2.687 0 Td [(E)-7.9 (xa)-10.8 (c)-10.7 (e)4.1 (r)-2.3 (b)-14.5 (a)4.2 (t)-12.6 (i)-12.6 (o)0.5 (n of)-2.3 ( C)3.2 (h)-14.4 (e)4.1 (m)-5.1 (o)0.5 (t)-12.6 (h)-14.5 (e)4.2 (r)-2.4 (a)-10.8 (p)-14.4 (y)]TJ 0 Tc 0 Tw 12.433 0 Td (-)Tj 0.008 Tc -0.004 Tw 0.343 0 Td [(I)42.5 (n)0.5 (d)0.6 (u)0.5 (c)19.1 (e)19.2 (d)0.5 ( N)13.6 (e)19.1 (u)0.6 (t)2.4 (r)12.6 (o)15.5 (p)0.5 (e)19.2 (n)0.5 (i)17.3 (a )]TJ EMC /Link <>BDC /TT1 1 Tf 0 Tc 0 Tw -18.149 -1.149 Td (6 )Tj -0.006 Tc 0.01 Tw 2.687 0 Td [(ADVE)-10.7 (RS)-2.2 (E)-10.7 ( RE)-10.7 (ACT)-10.6 (I)9.8 (O)-4.1 (NS )]TJ EMC /Span <>BDC /TT0 1 Tf -0.011 Tc 0 Tw 0 -1.149 TD [(6)-18.5 (.1 )]TJ EMC /Span <>BDC 0.004 Tc 2.687 0 Td [(C)-0.6 (l)13.3 (i)-1.6 (n)11.5 (i)-1.6 (cal)13.3 ( T)17.9 (r)8.7 (i)-1.6 (al)13.4 (s)4.9 ( E)3 (x)26.4 (p)-3.4 (e)15.1 (r)8.7 (i)-1.6 (e)15.2 (n)-3.5 (ce )]TJ EMC /Link <>BDC /TT1 1 Tf 0 Tc 30.448 24.03 Td (8 )Tj -0.006 Tc 0.01 Tw 2.687 0 Td [(US)-2.2 (E)-10.7 ( I)-5.1 (N S)-2.3 (P)8 (E)-10.6 (CI)-5.1 (F)-6.9 (I)-5.1 (C P)-7 (O)10.8 (P)-6.9 (U)]TJ -0.021 Tc 0.021 Tw [(L)-25.6 (A)-15.4 (T)-10.8 (I)-20 (O)-19.1 (NS )]TJ EMC /Span <>BDC /TT0 1 Tf -0.011 Tc 0 Tw T* [(8)-18.5 (.1 )]TJ EMC /Span <>BDC 0.004 Tc 2.687 0 Td [(P)7.8 (r)8.6 (e)15.2 (g)11.4 (n)-3.4 (an)-3.5 (cy )]TJ EMC /Span <>BDC -0.011 Tc -2.687 -1.134 Td [(8)-18.5 (.2 )]TJ EMC /Span <>BDC 0.004 Tc 2.687 0 Td [(L)32.9 (act)-1.6 (at)-1.5 (i)-1.6 (o)11.4 (n )]TJ EMC /Span <>BDC -0.011 Tc -2.687 -1.149 Td [(8)-18.5 (.3 )]TJ EMC /Span <>BDC 0.015 Tw 2.687 0 Td [(F)-7.2 (em)-9.1 (a)-14.8 (l)-1.6 (es)-10 ( a)-14.8 (n)-18.5 (d )-3.2 (M)-17.6 (a)-14.7 (l)-1.7 (es)-10.1 ( o)-3.6 (f)-6.3 ( R)-15.6 (ep)-18.5 (r)-6.4 (o)-3.5 (d)-3.6 (u)-18.4 (ct)-16.6 (i)-16.6 (v)-3.6 (e P)-7.3 (o)-3.5 (t)-16.6 (en)-18.5 (t)-16.6 (i)-1.6 (a)-14.8 (l )]TJ EMC /Span <>BDC 0 Tw -2.687 -1.149 Td [(8)-18.5 (.4 )]TJ EMC /Span <>BDC 0.006 Tc -0.002 Tw 2.687 0 Td [(P)9.8 (e)17.1 (d)-1.4 (ia)2.2 (tr)25.6 (ic)2.2 ( U)11.6 (s)6.9 (e )]TJ EMC /Span <>BDC -0.011 Tc 0 Tw -2.687 -1.134 Td [(8)-18.5 (.5 )]TJ EMC /Span <>BDC 0.006 Tc -0.002 Tw 2.687 0 Td [(G)11.6 (e)17.1 (r)10.7 (ia)2.2 (tr)10.7 (ic)2.2 ( U)11.6 (s)6.9 (e )]TJ EMC /Link <>BDC /TT1 1 Tf 0.008 Tc 0 Tw -5.373 -1.149 Td [(1)0.5 (0 )]TJ -0.006 Tc 2.687 0 Td [(O)-4.1 (VE)-10.7 (RDO)-4.1 (S)-2.3 (AG)-4.1 (E )]TJ EMC /Link <>BDC 0.008 Tc -2.687 -1.149 Td [(1)0.5 (1 )]TJ -0.006 Tc 2.687 0 Td [(DE)-10.7 (S)-2.2 (CRI)-5.1 (P)-6.9 (T)-10.7 (I)-5 (O)-4.1 (N )]TJ EMC /Link <>BDC 0.008 Tc -2.687 -1.134 Td [(1)0.5 (2 )]TJ -0.006 Tc 0.01 Tw 2.687 0 Td [(CL)-10.7 (I)-5 (NI)-5.1 (CAL)-10.6 ( P)-6.9 (H)-4.1 (ARM)-2.3 (ACO)-4.1 (L)4.3 (O)-4.1 (G)]TJ 0 Tc 0 Tw 13.418 0 Td (Y )Tj EMC /Span <>BDC /TT0 1 Tf -0.007 Tc -13.418 -1.149 Td [(1)-14.5 (2)0.5 (.)-10.7 (1 )]TJ EMC /Span <>BDC 0.006 Tc -0.002 Tw 2.687 0 Td [(Me)17.1 (c)2.3 (h)13.4 (a)2.3 (n)13.4 (is)7 (m)7.9 ( o)13.5 (f)10.6 ( A)26.5 (c)2.2 (ti)0.5 (o)28.3 (n )]TJ EMC /Span <>BDC -0.007 Tc 0 Tw -2.687 -1.149 Td [(1)-14.5 (2)0.5 (.)-10.7 (2 )]TJ EMC /Span <>BDC 0.004 Tc 2.687 0 Td [(P)7.8 (h)-3.5 (ar)8.7 (m)5.8 (a)15.2 (co)11.5 (d)-3.5 (y)26.4 (n)-3.4 (am)5.9 (i)13.3 (cs )]TJ EMC /Span <>BDC -0.007 Tc -2.687 -1.134 Td [(1)-14.5 (2)0.5 (.)-10.7 (3 )]TJ EMC /Span <>BDC 0.004 Tc 2.687 0 Td [(P)7.8 (h)-3.5 (ar)8.7 (m)5.8 (a)15.2 (co)11.5 (k)11.5 (i)-1.6 (n)-3.5 (e)15.2 (t)13.3 (i)-1.6 (cs )]TJ EMC /Link <>BDC /TT1 1 Tf 0.008 Tc -5.373 -1.149 Td [(1)0.5 (3 )]TJ -0.006 Tc 0.01 Tw 2.687 0 Td [(NO)-4.1 (NCL)-10.6 (I)-5.1 (NI)-5 (CAL)-10.6 ( T)-10.7 (O)-4.1 (X)14.5 (I)-5 (CO)-4.2 (L)-10.6 (O)]TJ -0.002 Tc 0.002 Tw 12.925 0 Td (GY )Tj EMC /Span <>BDC /TT0 1 Tf -0.007 Tc 0 Tw -12.925 -1.134 Td [(1)-14.5 (3)0.5 (.)-10.7 (1 )]TJ EMC /Span <>BDC 0.006 Tc -0.002 Tw 2.687 0 Td [(C)1.4 (a)2.2 (r)10.6 (c)17.2 (in)-1.5 (o)13.5 (g)13.5 (e)17.1 (n)-1.4 (e)17.1 (s)6.9 (i)0.5 (s)6.9 (, )17.5 (M)14.4 (u)-1.5 (t)15.3 (a)2.3 (g)13.4 (e)17.2 (n)-1.5 (e)17.2 (s)6.9 (is)7 (,)2.2 ( I)40.5 (m)7.9 (p)-1.5 (a)2.2 (ir)10.7 (m)7.9 (e)17.1 (n)-1.4 (t o)13.4 (f)10.6 ( F)24.7 (e)17.2 (r)10.6 (til)15.4 (it)]TJ 0 Tc 0 Tw (y )Tj EMC /Link <>BDC /TT1 1 Tf 0.008 Tc -5.373 -1.149 Td [(1)0.5 (4 )]TJ -0.006 Tc 0.01 Tw 2.687 0 Td [(CL)-10.7 (I)-5 (NI)-5.1 (CAL)-10.6 ( S)-2.2 (T)-10.7 (UDI)9.9 (E)-10.7 (S )]TJ EMC /Span <>BDC /TT0 1 Tf -0.007 Tc 0 Tw T* [(1)-14.5 (4)0.5 (.)-10.7 (1 )]TJ EMC /Span <>BDC -0.011 Tc 2.687 0 Td [(A)9.5 (d)-18.5 (j)-16.5 (u)-18.5 (v)-3.6 (a)-14.7 (n)-3.6 (t)-16.5 ( B)-15.7 (r)-6.3 (ea)-14.7 (s)-10.1 (t)-16.6 ( C)-15.6 (an)-18.4 (c)-14.8 (er )]TJ EMC /Span <>BDC -0.007 Tc -2.687 -1.134 Td [(1)-14.5 (4)0.5 (.)-10.7 (2 )]TJ EMC /Span <>BDC 0.004 Tc 2.687 0 Td [(M)-2.5 (e)15.1 (t)-1.5 (as)19.8 (t)-1.5 (at)13.3 (i)-1.5 (c)15.1 ( B)-0.7 (r)8.7 (e)15.2 (as)4.9 (t)13.4 ( C)14.3 (an)11.5 (ce)15.2 (r )]TJ EMC /Link <>BDC /TT1 1 Tf 0.008 Tc -5.373 -1.149 Td [(1)0.5 (6 )]TJ -0.006 Tc 0.01 Tw 2.687 0 Td [(H)-4.1 (O)-4.1 (W)8.9 ( S)-2.3 (UP)-6.9 (P)-7 (L)-10.6 (I)-5 (E)-10.7 (D)14.5 (/)-11.6 (S)-2.2 (T)-10.6 (O)-4.1 (RAG)10.8 (E )-12 (AND)14.5 ( H)-4.1 (ANDL)-10.8 (I)-5 (NG )]TJ EMC /Span <>BDC /TT0 1 Tf -0.007 Tc 0 Tw T* [(1)-14.5 (6)0.5 (.)-10.7 (1 )]TJ EMC /Span <>BDC 0.008 Tc -0.004 Tw 2.687 0 Td [(H)13.6 (o)0.5 (w)28.5 ( S)11.7 (u)0.6 (p)15.4 (p)0.6 (l)17.3 (i)2.4 (e)19.2 (d )]TJ EMC /Span <>BDC -0.007 Tc 0 Tw -2.687 -1.134 Td [(1)-14.5 (6)0.5 (.)-10.7 (2 )]TJ EMC /Span <>BDC 2.687 0 Td [(S)-3.2 (t)-12.6 (or)-2.3 (a)-10.8 (g)0.5 (e )]TJ EMC /Link <>BDC /TT1 1 Tf 0.008 Tc -5.373 -1.149 Td [(1)0.5 (7 )]TJ -0.006 Tc 0.01 Tw 2.686 -0.001 Td [(P)-6.9 (AT)-10.6 (I)-5 (E)-10.7 (N)14.5 (T)-10.6 ( CO)-4.1 (UNS)-2.2 (E)4.2 (L)-10.6 (I)-5 (NG)-4.1 ( I)]TJ 0.006 Tw 12.015 0 Td [(NF)-7 (O)-4.1 (R)14.5 (M)-2.3 (AT)-10.6 (I)-5.1 (O)-4.1 (N )]TJ EMC /Span <>BDC /TT0 1 Tf -0.011 Tc 0 Tw -47.836 -2.284 Td [(6)-18.5 (.2 )]TJ EMC /Link <>BDC 0.008 Tc 2.687 0 Td [(I)27.6 (m)9.8 (m)9.9 (u)0.5 (n)0.6 (o)15.4 (g)15.5 (e)19.1 (n)0.6 (i)2.4 (c)4.2 (i)17.4 (t)2.4 (y)]TJ /T1_0 1 Tf (\003 )Tj EMC /Span <>BDC /TT1 1 Tf -0.004 Tc 0.008 Tw 30.448 0 Td [(*)-11.5 (Se)-7.7 (c)-7.8 (t)15.5 (i)-9.5 (o)-11.5 (ns)11.8 ( o)3.5 (r)-7.8 ( s)-3.1 (ubs)-3.1 (e)7.2 (c)-7.8 (t)0.7 (i)5.3 (o)-11.5 (ns )12.1 (o)-11.4 (m)23 (i)-9.6 (t)0.7 (t)0.6 (e)-7.7 (d f)-14.3 (r)7.2 (o)3.4 (m)23.1 ( t)0.7 (he)-7.7 ( f)-14.2 (ul)-9.6 (l)-9.5 ( p)14.7 (r)-7.7 (e)-7.8 (s)-3.1 (c)7.2 (r)-7.7 (i)-9.6 (b)14.7 (i)-9.6 (ng)3.5 ( i)-9.6 (n)14.7 (f)0.6 (o)-11.4 (r)-7.8 (m)23 (a)-11.4 (t)0.6 (i)-9.6 (o)-11.4 (n )]TJ EMC /Span <>BDC /TT0 1 Tf -0.011 Tc 0 Tw -33.134 -1.15 Td [(6)-18.5 (.3 )]TJ EMC /Link <>BDC -0.007 Tc 0.007 Tw 2.687 0 Td [(P)-3.2 (os)-6 (t)]TJ 0 Tc 0 Tw 1.716 0 Td (-)Tj 0.008 Tc -0.004 Tw 0.328 0 Td [(M)1.5 (a)4.2 (r)27.6 (k)0.5 (e)19.2 (t)2.4 (i)17.3 (n)0.6 (g)15.4 ( E)7 (x)15.5 (p)0.5 (e)19.2 (r)12.6 (i)2.4 (e)19.2 (n)0.5 (c)4.3 (e )]TJ EMC /Span <>BDC /TT1 1 Tf -0.004 Tc 0.008 Tw 28.404 0.001 Td [(a)-11.5 (r)-7.7 (e)7.1 ( no)-11.5 (t)15.6 ( l)-9.5 (i)5.3 (s)-3 (t)0.6 (e)-7.8 (d.)]TJ /T1_0 1 Tf (\002 )Tj EMC /Link <>BDC /TT1 1 Tf -0.006 Tc 0.01 Tw -33.134 -1.15 Td [(DRUG)-4.2 ( I)-5 (NT)-10.6 (E)-10.7 (RACT)-10.6 (I)-5.1 (O)-4.1 (NS)]TJ /T1_0 1 Tf (\002 )Tj EMC /P <>BDC /CS0 cs 0 scn /TT0 1 Tf 0 Tc 0 Tw 12 0 0 12 274.4214 38.0597 Tm (1 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 17.4214 9.4197 Tm (Reference ID: 4363704 )Tj EMC /Artifact <>BDC /CS1 cs 0 scn /TT1 1 Tf 8.04 0 0 8.04 43.4214 72.9797 Tm (7 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4572 0 obj <>>>/Resources 4504 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4573 0 obj <> endobj 4574 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
 endstream endobj 4575 0 obj <> endobj 4576 0 obj <>stream q 1 0 0 1 25.200867 16.96875 cm 0 0 612 792 re W n /Artifact <>BDC q 1 0 0 1 -25.200867 -16.96875 cm BT /CS0 cs 0 scn /TT0 1 Tf 3 Tr 12 0 0 12 97.2009 55.6088 Tm ( )Tj 20 0 Td ( )Tj 19 0 Td ( )Tj -30.72 55.83 Td ( )Tj /TT1 1 Tf 14.04 0 0 14.04 121.6867 697.8487 Tm ( )Tj 5.368 0 Td ( )Tj /TT0 1 Tf 12 0 0 12 297.9609 677.5688 Tm ( )Tj 16.95 0 Td ( )Tj -27.93 -1.17 Td ( )Tj /TT1 1 Tf 14.04 0 0 14.04 111.2409 623.8088 Tm ( )Tj 21.906 0 Td ( )Tj /TT0 1 Tf 12 0 0 12 177.8409 603.4088 Tm ( )Tj /TT2 1 Tf -3.26 -1.72 Td ( )Tj /TT0 1 Tf 10.56 -1.17 Td ( )Tj 20.13 0 Td [( )-1230 ( )]TJ -8.47 -1.16 Td ( )Tj 11.23 0 Td ( )Tj -14.89 -1.17 Td ( )Tj /TT3 1 Tf 8.75 0 Td ( )Tj /TT0 1 Tf 7.62 0 Td ( )Tj -29.2 -1.67 Td ( )Tj /TT2 1 Tf -5.73 -1.72 Td ( )Tj /TT0 1 Tf 32.95 0 Td ( )Tj 1.83 -1.17 Td ( )Tj -1.01 -1.16 Td ( )Tj -28.85 -1.17 Td ( )Tj 20.36 0 Td ( )Tj /TT2 1 Tf -25.28 -1.72 Td ( )Tj /TT0 1 Tf 32.27 0 Td ( )Tj -4.8 -1.17 Td ( )Tj /TT3 1 Tf 0.001 Tc -0.001 Tw 1.91 0 Td [( )-2599.9 ( )]TJ /TT0 1 Tf 0 Tc 0 Tw -17.29 -1.17 Td ( )Tj /TT1 1 Tf 8.04 0 0 8.04 97.2009 393.4087 Tm ( )Tj ET Q /CS0 cs 0 scn 70.56 372.24 470.88 1.44 re f* q 1 0 0 1 -25.200867 -16.96875 cm BT /TT1 1 Tf 3 Tr 12 0 0 12 165.8409 371.9288 Tm ( )Tj /TT0 1 Tf 8.82 0 Td ( )Tj -14.54 -1.65 Td ( )Tj 7.14 -1.65 Td ( )Tj 1 -1.65 Td ( )Tj -1.39 -1.65 Td ( )Tj 1.36 -1.15 Td ( )Tj 2.27 -1.15 Td ( )Tj 0.01 Tw -5.25 -1.15 Td ( )Tj 0 Tw 4.87 0 Td ( )Tj -4.56 -1.65 Td ( )Tj -0.004 Tc 0.004 Tw 17.24 0 Td ( )Tj 0 Tc 0 Tw 1.79 0 Td ( )Tj -24.47 -1.65 Td ( )Tj 5.36 -1.65 Td ( )Tj /TT1 1 Tf 4.1 -1.65 Td [( )-4150 ( )]TJ /TT0 1 Tf 0.15 -1.65 Td ( )Tj ET Q EMC 1 0 0 1 -25.200867 -16.96875 cm BT /P <>BDC /TT0 1 Tf 12 0 0 12 97.2009 725.5688 Tm [(N)2 (D)2 (C)-3 ( 63459-)3 (305-)3 (47. )]TJ EMC /Span <>BDC /TT1 1 Tf 0.004 Tc 14.04 0 0 14.04 97.2009 697.8487 Tm [(16.)14.7 (2 )]TJ EMC /Span <>BDC 3.847 0 Td [(S)4.4 (t)3.7 (or)12.1 (ag)8.3 (e )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 12 0 0 12 97.2009 677.5688 Tm [(S)-4 (t)-2 (or)3 (e)4 ( H)2 (E)1 (R)-3 (Z)11 (U)2 (M)-11 (A)2 ( vi)-2 (a)4 (l)-2 (s)-1 ( i)-2 (n t)-2 (he)4 ( r)3 (e)4 (f)3 (r)3 (i)-12 (ge)4 (r)3 (a)4 (t)-2 (or )-7 (a)4 (t)-2 ( 2\260C)-3 ( t)-2 (o 8\260C)-3 ( \()3 (36\260F)6 ( t)-2 (o 46\260F)6 (\))3 ( unt)-2 (i)-12 (l)-2 ( t)-2 (i)-2 (m)-2 (e)4 ( of )]TJ 0 -1.17 TD [(r)3 (e)4 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (i)-2 (on. )]TJ EMC /P <>BDC /TT1 1 Tf 0.004 Tc 14.04 0 0 14.04 97.2009 623.8088 Tm (17 )Tj -0.004 Tc 0.002 Tw 3.846 0 Td [(PAT)-3.6 (I)-8.2 (E)-3.7 (NT)-3.7 ( CO)-3.8 (UNS)-3.5 (E)-3.7 (L)-3.7 (I)-8.1 (NG)-3.7 ( I)-8.2 (NFO)-3.8 (RMAT)-3.6 (I)-8.2 (O)-3.8 (N )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw 12 0 0 12 97.2009 603.4088 Tm [(C)-3 (a)4 (r)3 (di)-2 (om)-12 (y)20 (opa)4 (t)-2 (h)-20 (y )]TJ EMC /Span <>BDC /C2_0 1 Tf 3 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /Span <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 1.5 0 Td [(A)-2 (d)-4 (v)-4 (i)-6 (s)-5 (e p)-4 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( t)-6 (o)-4 ( co)-4 (n)-4 (t)-6 (ac)-9.9 (t)-6.1 ( a h)-4 (eal)-6 (t)-6 (h)-4 ( ca)-10 (r)-1 (e p)-4 (r)-1 (o)-14 (f)-1 (es)-5 (s)-5 (i)-6 (o)-4 (n)-14 (al)-6 ( i)-6 (m)-6 (m)-6 (ed)-4 (i)-6 (at)-6 (el)-16 (y)16 ( f)-1 (o)-14 (r)-1 ( an)-24 (y)16 ( o)-4 (f)-11 ( t)-5.9 (h)-4 (e )]TJ 0 Tc 0 Tw T* [(f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng)10 (:)-2 ( ne)4 (w)2 ( ons)-11 (e)4 (t)-2 ( or )-7 (w)2 (or)3 (s)-1 (e)4 (ni)-2 (n)-10 (g)10 ( s)-1 (hor)3 (t)-2 (ne)4 (s)-1 (s)-1 ( of)3 ( b)-10 (r)3 (e)4 (a)4 (t)-2 (h, c)4 (ou)-10 (g)10 (h, s)-1 (w)-8 (e)4 (l)-2 (l)-2 (i)-2 (ng)10 ( of )-7 (t)-2 (he )]TJ 0 -1.16 TD [(a)4 (nkl)-2 (e)4 (s)-1 (/)-2 (l)-2 (e)4 (g)10 (s)-1 (, s)-11 (w)2 (e)4 (l)-2 (l)-2 (i)-2 (ng)10 ( o)-10 (f)3 ( t)-2 (he)4 ( f)3 (a)4 (c)-6 (e)4 (, pa)4 (l)-2 (pi)-2 (t)-2 (a)4 (t)-2 (i)-2 (ons)-1 (, w)2 (e)4 (i)-12 (g)10 (ht )-12 (g)10 (a)4 (i)-2 (n of)3 ( m)-2 (or)-7 (e)4 ( t)-2 (ha)4 (n 5 p)-10 (ounds )-1 (i)-2 (n )]TJ 0 -1.17 TD [(24 hour)3 (s)-1 (, di)-2 (z)-6 (z)-6 (i)-2 (ne)4 (s)-1 (s)-1 ( or)3 ( l)-2 (os)9 (s)-1 ( of)3 ( c)4 (ons)-1 (c)4 (i)-2 (ous)-1 (ne)4 (s)-1 (s )]TJ /TT3 1 Tf -0.004 Tc 0.004 Tw 17.77 0 Td [([)-5 (s)-5 (ee )]TJ 0 Tc 0.01 Tw 1.92 0 Td [(B)-9 (ox)4 (e)4 (d W)13 (ar)-1 (ni)-2 (ng)]TJ 0 Tw [(: )3 (C)-3 (ar)-1 (di)-2 (om)2 (y)-6 (opat)-2 (hy)24 (])]TJ /TT0 1 Tf 13.97 0 Td (. )Tj EMC /P <>BDC -0.02 Tc 0.02 Tw -38.16 -1.67 Td [(E)-19 (m)-22 (b)-20 (r)-27 (yo)]TJ 0 Tc 0 Tw 3.21 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.34 0 Td [(F)-8 (et)-6 (al)-6 ( T)-3 (o)]TJ 0.002 Tc -0.002 Tw 3.36 0 Td [(x)-8 (ic)6 (it)-10 (y )]TJ EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 0 Tw -3.91 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(A)2 (dvi)-2 (s)-1 (e)4 ( pr)3 (e)-6 (g)10 (na)4 (nt)-2 ( w)2 (om)-12 (e)4 (n )-10 (a)4 (nd f)3 (e)4 (m)-2 (a)4 (l)-2 (e)4 (s)-1 ( o)-10 (f)3 ( r)3 (e)4 (p)-10 (r)3 (oduc)4 (t)-12 (i)-2 (ve)4 ( pot)-2 (e)4 (nt)-2 (i)-2 (a)4 (l)-2 ( t)-2 (ha)4 (t)-2 ( H)2 (E)1 (R)-3 (Z)1 (U)2 (M)-1 (A )]TJ T* [(e)4 (x)-10 (pos)-1 (ur)3 (e)4 ( dur)3 (i)-2 (ng)10 ( pr)-7 (e)-6 (g)10 (na)4 (n)-10 (c)-6 (y)20 ( o)-10 (r)3 ( w)2 (i)-2 (t)-2 (hi)-2 (n 7 m)-2 (ont)-2 (hs)-1 ( pr)3 (i)-2 (or)3 ( t)-2 (o c)4 (onc)4 (e)4 (pt)-2 (i)-2 (on c)-6 (a)4 (n r)3 (e)4 (s)-1 (u)-10 (l)-2 (t)-2 ( i)-2 (n f)3 (e)4 (t)-2 (a)4 (l )]TJ 0.002 Tc -0.002 Tw 0 -1.16 TD [(h)2 (a)6 (r)5 (m.)2 ( A)4 (d)2 (v)2 (is)1 (e)6 ( f)-5 (e)6 (ma)6 (le)6 ( p)2 (a)6 (ti)-10 (e)6 (n)2 (ts)1 ( to)2 ( c)6 (o)2 (n)2 (ta)6 (c)6 (t th)2 (e)6 (ir)5 ( h)2 (e)-4 (a)5.9 (lth)2.1 (c)]TJ 0 Tc 0 Tw 21.1 0 Td [(a)4 (r)3 (e)4 ( p)-10 (r)3 (ovi)-2 (de)4 (r)3 ( w)2 (i)-2 (t)-2 (h a)4 ( kn)-10 (ow)2 (n or )]TJ -0.004 Tc 0.004 Tw -21.1 -1.17 Td [(s)-5 (u)-4 (s)-5 (p)-4 (ect)-6 (ed )]TJ 0 Tc 0 Tw 4.13 0 Td [(pr)3 (e)-6 (gna)4 (nc)-16 (y)20 ( [)]TJ /TT3 1 Tf 4.75 0 Td [(s)-1 (e)4 (e)-6 ( U)2 (s)-1 (e)4 ( i)-2 (n Spe)4 (c)4 (i)-2 (f)-2 (i)-2 (c)4 ( P)1 (opul)-2 (at)-2 (i)-2 (ons)-1 ( \()13 (8.1)-10 (\))]TJ /TT0 1 Tf 0.007 Tc 14.76 0 Td (]. )Tj EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc -25.14 -1.72 Td <0078>Tj /T1_0 1 Tf 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Tf 8 0 0 8 35.2009 26.9688 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4577 0 obj <>>>/Resources 4536 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4578 0 obj <> endobj 4579 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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322.3072 688.8386 Tm [(f)-25.8 (or )-23.6 (T)-7.1 (i)-4.7 (m)-15 (e)-12.6 ( t)-15 (o )]TJ 0.002 Tc -0.013 Tw -4.946 -1.141 Td [(D)6.6 (i)-2.6 (sea)2 (s)10.6 (e P)-6.6 (ro)2 (g)12.9 (res)10.5 (si)-2.6 (o)2 (n )]TJ 0 Tc 0 Tw 2.218 -1.152 Td [(\()-4 (95%)10.9 ( C)4.6 (I)-2.3 (\) )]TJ EMC /TH <>BDC 0.002 Tc -0.002 Tw 11 1.728 Td [(R)6.6 (el)-2.7 (a)2 (t)9 (i)-2.7 (v)2 (e R)17.5 (i)-2.6 (sk)]TJ 0 Tc 0 Tw 6.96 0 0 6.96 476.3886 686.5586 Tm (b )Tj -0.011 Tc 0.011 Tw 11.04 0 0 11.04 482.8672 682.5986 Tm [(f)-25.8 (or)-12.6 ( M)-12.7 (or)-12.7 (t)-14.9 (al)-15.6 (i)-4.8 (t)-15 (y )]TJ 0 Tc 0 Tw -2.327 -1.163 Td [(\()-4 (95%)10.9 ( C)4.6 (I)-2.3 (\) )]TJ EMC /TH <>BDC /TT0 1 Tf -0.011 Tc 0.011 Tw -32.358 -2.315 Td [(C)-7 (T)-19.6 (A)-6.4 ( 2)-11 (+)-12.2 ( or )]TJ 0 Tc 0 Tw 0 -1.152 TD (3+ )Tj EMC /TD <>BDC 8.25 0.565 Td (469 )Tj EMC /TD <>BDC 7.848 0 Td [(0.49 \()-3.9 (0.)10.8 (40, 0.61)10.9 (\) )]TJ EMC /TD <>BDC 14.945 0 Td [(0.80 \()-3.9 (0.)10.8 (64, 1.00)10.9 (\) )]TJ EMC /TH <>BDC -0.018 Tc 0.018 Tw -29.956 -2.326 Td [(F)-27.2 (IS)-16.4 (H)-13.4 ( \()-22 (+)-19.2 (\))]TJ 0 Tc 0 Tw 6.96 0 0 6.96 152.1486 615.9986 Tm (a )Tj EMC /TD <>BDC 11.04 0 0 11.04 191.0286 612.0386 Tm (325 )Tj EMC /TD <>BDC 7.848 0 Td [(0.44 \()-3.9 (0.)10.8 (34, 0.57)10.9 (\) )]TJ EMC /TD <>BDC 14.945 0 Td [(0.70 \()-3.9 (0.)10.8 (53, 0.91)10.9 (\) )]TJ EMC /TH <>BDC -0.018 Tc -29.956 -1.761 Td [(F)-27.2 (IS)-16.4 (H )]TJ /C2_0 1 Tf 0.001 Tc 2.402 0 Td [<000B>-2.9 <00ED000C>]TJ /TT0 1 Tf 0 Tc 6.96 0 0 6.96 152.1486 596.5586 Tm (a )Tj EMC /TD <>BDC 11.04 0 0 11.04 191.0286 592.5986 Tm (126 )Tj EMC /TD <>BDC 7.848 0 Td [(0.62 \()-3.9 (0.)10.8 (42, 0.94)10.9 (\) )]TJ EMC /TD <>BDC 14.945 0 Td [(1.06 \()-3.9 (0.)10.8 (70, 1.63)10.9 (\) )]TJ EMC /TH <>BDC -0.005 Tc 0.005 Tw -31.043 -1.75 Td [(C)-1 (T)-13.6 (A 2)-5 (+ )]TJ EMC /TD <>BDC 0 Tc 0 Tw 8.25 0 Td (120 )Tj EMC /TD <>BDC 7.848 0 Td [(0.76 \()-3.9 (0.)10.8 (50, 1.15)10.9 (\) )]TJ EMC /TD <>BDC 14.945 0 Td [(1.26 \()-3.9 (0.)10.8 (82, 1.94)10.9 (\) )]TJ EMC /TH <>BDC -0.018 Tc 0.018 Tw -29.956 -1.761 Td [(F)-27.2 (IS)-16.4 (H)-13.4 ( \()-22 (+)-19.2 (\) )]TJ EMC /TD <>BDC 0 Tc 0 Tw 7.413 0 Td (32 )Tj EMC /TD <>BDC 7.598 0 Td [(0.54 \()-4 (0.)10.9 (21, 1.35)10.9 (\) )]TJ EMC /TD <>BDC 14.945 0 Td [(1.31 \()-4 (0.)10.9 (53, 3.27)10.9 (\) )]TJ EMC /TH <>BDC -0.018 Tc 0.018 Tw -29.956 -1.761 Td [(F)-27.2 (IS)-16.4 (H)-13.4 ( \()]TJ 0 Tc 0 Tw 2.739 0 Td (\226\) )Tj EMC /TD <>BDC 4.674 0 Td (83 )Tj EMC /TD <>BDC 7.598 0 Td [(0.77 \()-4 (0.)10.9 (48, 1.25)10.9 (\) )]TJ EMC /TD <>BDC 14.945 0 Td [(1.11 \()-4 (0.)10.9 (68, 1.82)10.9 (\) )]TJ EMC /TH <>BDC -0.005 Tc 0.005 Tw -31.043 -1.75 Td [(C)-1 (T)-13.6 (A 3)-5 (+ )]TJ EMC /TD <>BDC 0 Tc 0 Tw 8.25 0 Td (349 )Tj EMC /TD <>BDC 7.848 0 Td [(0.42 \()-3.9 (0.)10.8 (33, 0.54)10.9 (\) )]TJ EMC /TD <>BDC 14.945 0 Td [(0.70 \()-3.9 (0.)10.8 (51, 0.90)10.9 (\) )]TJ EMC /TH <>BDC -0.018 Tc 0.018 Tw -29.956 -1.761 Td [(F)-27.2 (IS)-16.4 (H)-13.4 ( \()-22 (+)-19.2 (\) )]TJ EMC /TD <>BDC 0 Tc 0 Tw 7.163 0 Td (293 )Tj EMC /TD <>BDC 7.848 0 Td [(0.42 \()-4 (0.)10.9 (32, 0.55)10.9 (\) )]TJ EMC /TD <>BDC 14.945 0 Td [(0.67 \()-4 (0.)10.9 (51, 0.89)10.9 (\) )]TJ EMC /TH <>BDC -0.018 Tc 0.018 Tw -29.956 -1.761 Td [(F)-27.2 (IS)-16.4 (H)-13.4 ( \()]TJ 0 Tc 0 Tw 2.739 0 Td (\226\) )Tj EMC /TD <>BDC 4.674 0 Td (43 )Tj EMC /TD <>BDC 7.598 0 Td [(0.43 \()-4 (0.)10.9 (20, 0.94)10.9 (\) )]TJ EMC /TD <>BDC 14.945 0 Td [(0.88 \()-4 (0.)10.9 (39, 1.98)10.9 (\) )]TJ EMC /StyleSpan <>BDC 6.48 0 0 6.48 94.1886 464.3186 Tm (a )Tj EMC /P <>BDC 0.002 Tc 0.001 Tw 9.96 0 0 9.96 99.5885 460.8386 Tm [(F)3.8 (I)-2.4 (S)3.8 (H)1.1 ( t)2.9 (es)5.5 (t)2.9 (i)-9.2 (n)-4 (g)8 ( r)-2.3 (es)5.4 (u)8 (l)-9.1 (t)2.9 (s )-6.6 (w)13.1 (er)-2.3 (e av)-4 (ai)2.9 (l)2.9 (ab)-4 (l)2.9 (e f)9.7 (o)-4 (r)-2.4 ( 4)-4 (5)-4 (1 )]TJ 0.006 Tc -0.003 Tw 17.482 0 Td [(of)13.7 ( t)6.9 (h)12.1 (e)4.2 ( 469 pa)4.2 (t)6.9 (i)6.9 (e)4.2 (n)12 (t)6.9 (s)9.5 ( e)-7.9 (n)12.1 (r)1.6 (ol)6.9 (l)6.9 (e)4.2 (d on)12 ( s)9.4 (t)6.9 (u)12 (d)-12 (y)12 (.)]TJ /T1_0 1 Tf (\002 )Tj EMC /StyleSpan <>BDC /TT0 1 Tf 0 Tc 0 Tw 6.48 0 0 6.48 94.1886 452.7987 Tm (b )Tj EMC /P <>BDC 0.002 Tc 0.001 Tw 9.96 0 0 9.96 99.9485 449.3186 Tm [(T)-13.5 (h)8 (e r)-2.3 (el)2.9 (at)2.9 (i)2.9 (v)8 (e r)-2.3 (i)2.9 (s)5.4 (k)8 ( r)-2.3 (ep)-4 (r)-2.4 (es)5.5 (en)8 (t)-9.1 (s)5.4 ( t)-9.1 (h)8 (e r)-2.4 (i)2.9 (s)-6.6 (k)8.1 ( o)-4.1 (f)9.7 ( p)-4 (r)-2.3 (o)-4.1 (g)8 (r)-2.3 (es)5.5 (s)5.4 (i)2.9 (o)-4 (n)8 ( o)-4 (r)-2.4 ( d)-4 (eat)2.9 (h)-4 ( i)2.9 (n)8 ( t)2.9 (h)8 (e t)2.9 (r)-2.3 (as)-6.6 (t)2.9 (u)8 (z)-11.8 (u)-4.1 (m)9 (ab)-4 ( p)-4 (l)2.9 (u)8 (s)5.5 ( c)-11.9 (h)8.1 (e)-11.9 (m)-3.1 (o)-4 (t)2.9 (h)8 (er)-2.3 (ap)-16.1 (y)20.1 ( ar)-14.4 (m)20.9 ( v)8.1 (er)-14.4 (s)5.4 (u)-4 (s)5.5 ( t)2.9 (h)8 (e )]TJ /T1_0 1 Tf (\002)Tj /TT0 1 Tf -0.578 -1.157 Td [(ch)8 (e)-11.8 (m)21 (o)-4.1 (t)-9.1 (h)8 (er)-2.3 (ap)-16.1 (y)20.1 ( ar)-14.4 (m)21 (.)]TJ /T1_0 1 Tf (\002 )Tj EMC /P <>BDC /TT2 1 Tf -0.004 Tc 0.004 Tw 12 0 0 12 94.1886 412.2386 Tm [(P)-3 (r)-5 (evi)-6 (o)-4 (u)-4 (s)-5 (l)-6 (y T)-8 (r)-5 (ea)-4 (t)-6 (ed)-4 ( M)-1 (et)-6 (a)-13.9 (s)-5.1 (t)-5.9 (a)-4 (t)-6.1 (i)-5.9 (c B)-3 (r)-5 (ea)-4 (s)-5 (t)-6 ( C)-7 (a)-4 (n)-4 (cer)-5 ( \()9 (S)-4 (t)-6 (u)-14 (d)-4 (y 6)-14 (\) )]TJ EMC /P <>BDC /TT0 1 Tf 0 -1.66 TD [(T)-3 (r)-1 (as)-5 (t)-6 (u)-4 (z)-10 (u)-4 (m)-6 (ab )-4 (w)-2 (as)-5 ( s)-5 (t)-6 (u)-4 (d)-4 (i)-6 (ed)-4 ( as)-5 ( a )]TJ 0.002 Tc -0.002 Tw [(s)1 (in)2 (g)12 (l)-10 (e)6 ( a)-4 (g)12 (e)6 (n)2 (t in)2 ( a)6 ( mu)-8 (ltic)6 (e)6 (n)2 (te)6 (r)5 (,)2 ( o)2 (p)2 (e)6 (n)]TJ 0 Tc 0 Tw 25.95 0 Td (-)Tj 0.002 Tc -0.002 Tw 0.33 0 Td [(la)6 (b)-8 (e)6 (l,)2 ( s)1 (in)2 (g)2 (le)]TJ 0 Tc 0 Tw 4.84 0 Td (-)Tj 0.002 Tc -0.002 Tw 0.33 0 Td [(a)6 (r)5 (m c)6 (lin)2 (ic)6 (a)6 (l tr)5 (i)-10 (a)6 (l )]TJ -0.003 Tc 0.003 Tw -31.45 -1.17 Td [(\(S)-7 (t)-5 (u)-3 (d)-13 (y )]TJ -0.004 Tc 0.004 Tw 2.91 0 Td [(6)-4 (\))-1 ( i)-6 (n)-4 ( p)-4 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( w)-2 (i)-6 (t)-6 (h)-14 ( H)-2 (E)-3 (R)-7 (2)-4 ( o)-3.9 (v)-4 (er)-1 (ex)-14 (p)-4 (r)-1 (es)-5 (s)-5 (i)-6 (n)-4 (g)6 ( m)-16 (et)-6 (as)-5 (t)-6 (at)-6 (i)-6 (c b)-4 (r)-1 (e)-10 (as)-5 (t)-6 ( can)-14 (cer)-1 ( w)-12 (h)-4 (o)-4 ( h)-4 (ad)-4 ( r)-1 (el)-6 (ap)-3.9 (s)-15 (ed )]TJ 0 Tc 0 Tw -2.91 -1.17 Td [(f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng)10 ( one)4 ( o)-10 (r)3 ( t)-2 (w)2 (o pr)3 (i)-12 (or)3 ( c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)-7 (a)4 (p)-20 (y)20 ( r)3 (e)-6 (g)10 (i)-2 (m)-2 (e)-6 (ns)-1 ( f)3 (or)3 ( m)-2 (e)4 (t)-2 (a)4 (s)-1 (t)-2 (a)4 (t)-2 (i)-2 (c)4 ( di)-2 (s)-1 (e)4 (a)4 (s)-11 (e)4 (.)-10 ( O)2 (f)3 ( 222 )]TJ 0.002 Tc -0.002 Tw [(p)2 (a)6 (tie)6 (n)2 (ts )]TJ 0 Tc 0 Tw 0 -1.16 TD [(e)4 (nr)3 (ol)-2 (l)-2 (e)4 (d, 66%)3 ( ha)4 (d )-10 (r)3 (e)4 (c)-6 (e)4 (i)-2 (v)-10 (e)4 (d pr)3 (i)-2 (or)3 ( a)4 (dj)-2 (uva)4 (nt )-12 (c)4 (he)4 (m)-2 (ot)-12 (he)4 (r)3 (a)4 (p)-20 (y)20 (, 68%)3 ( h)-10 (a)4 (d r)-7 (e)4 (c)4 (e)4 (i)-2 (ve)-6 (d t)-2 (w)2 (o pr)3 (i)-2 (or )]TJ -0.004 Tc 0.004 Tw 0 -1.17 TD [(ch)-4 (em)-6 (o)-4 (t)-6 (h)-4 (er)-1 (ap)-24 (y )6 (r)-1 (e)-10 (g)6 (i)-6 (m)-6 (en)-4 (s)-5 ( f)-10.9 (o)-4 (r)-1 ( m)-6.1 (et)-5.9 (as)-5 (t)-6 (at)-6 (i)-6 (c d)-4 (i)-6 (s)-5 (eas)-15 (e,)-4 ( an)-4 (d)-14 ( 2)-4 (5)-4 (%)-1 ( h)-4 (ad)-4 ( r)-1 (e)-10 (cei)-6 (v)-4 (ed)-4 ( p)-14 (r)-1 (i)-6 (o)-4 (r )-11 (m)-16 (y)16 (el)-6 (o)-4 (ab)-4 (l)-15.9 (at)-6 (i)-6 (v)-4 (e )]TJ T* [(t)-6 (r)-1 (eat)-6 (m)-6 (en)-4 (t)-6 ( w)-2 (i)-6 (t)-6 (h)-4 ( h)-4 (em)-6 (at)-6 (o)-4 (p)-4 (o)-13.9 (i)-6.1 (et)-6 (i)-5.9 (c r)-1 (es)-5 (cu)-14 (e.)-4 ( P)-8 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( w)-2 (er)-11 (e t)-6 (r)-1 (eat)-6 (ed )-14 (w)-2 (i)-6 (t)-6 (h)-4 ( a l)-6 (o)-4 (ad)-4 (i)-6 (n)-14 (g)6 ( d)-14 (o)-3.9 (s)-5 (e o)-3.9 (f)-1 ( 4 )]TJ -0.01 Tc 0.03 Tw 33.49 0 Td [(m)-12 (g/)-12 (k)-20 (g I)3 (V )]TJ -0.003 Tc 0.003 Tw -33.49 -1.17 Td (fo)Tj 0 Tc 0 Tw 0.83 0 Td [(l)-2 (l)-2 (ow)2 (e)4 (d b)-20 (y)20 ( w)2 (e)-6 (e)4 (kl)-12 (y)20 ( dos)-11 (e)-6 (s)-1 ( of)3 ( t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b a)4 (t)-2 ( 2 )]TJ -0.01 Tc 0.02 Tw [(m)-12 (g/)-22 (k)-10 (g I)3 (V)-17.9 (. )]TJ EMC /P <>BDC 0 Tc 0 Tw -0.83 -1.66 Td [(T)1 (he)4 ( O)2 (R)-3 (R)-3 ( \()3 (c)4 (om)-2 (pl)-2 (e)4 (t)-2 (e)4 ( r)-7 (e)4 (s)-1 (p)-10 (ons)-1 (e)4 ( +)4 ( pa)4 (r)3 (t)-2 (i)-2 (a)4 (l)-2 ( r)-7 (e)4 (s)-1 (pons)-1 (e)4 (\))3 (, )-10 (a)4 (s)-1 ( de)4 (t)-2 (e)4 (r)3 (m)-2 (i)-2 (ne)4 (d b)-20 (y )10 (a)4 (n )-10 (I)13 (nde)-6 (pe)4 (nde)4 (nt)-2 ( R)-3 (e)4 (s)-1 (pons)-1 (e )]TJ T* [(E)1 (va)4 (l)-2 (ua)4 (t)-2 (i)-2 (on C)-3 (om)-2 (m)-2 (i)-2 (t)-2 (t)-2 (e)4 (e)4 (, w)2 (a)4 (s)-1 ( 14%)3 (, w)2 (i)-2 (t)-2 (h a)4 ( 2% )-7 (c)4 (om)-12 (pl)-2 (e)4 (t)-2 (e)4 ( r)3 (e)4 (s)-1 (pons)-1 (e )-6 (r)3 (a)4 (t)-2 (e )-6 (a)4 (nd a )-6 (12%)3 ( pa)4 (r)3 (t)-2 (i)-2 (a)4 (l)-2 ( r)3 (e)4 (s)-1 (pons)-11 (e )]TJ -0.004 Tc 0.004 Tw 0 -1.16 TD [(r)-1 (at)-6 (e.)-4 ( C)-7 (o)-4 (m)-6 (p)-4 (l)-6 (et)-6 (e )]TJ 0 Tc 0 Tw [(r)3 (e)4 (s)-1 (pons)-11 (e)4 (s)-11 ( w)2 (e)4 (r)3 (e)4 ( obs)-11 (e)4 (r)3 (ve)4 (d onl)-22 (y)20 ( i)-2 (n p)-10 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h di)-2 (s)-1 (e)4 (a)4 (s)-1 (e)4 ( l)-2 (i)-2 (m)-2 (i)-2 (t)-2 (e)4 (d t)-2 (o s)-1 (ki)-2 (n a)4 (nd l)-12 (y)20 (m)-2 (ph )]TJ 0 -1.17 TD [(node)4 (s)-1 (. T)1 (he)4 ( ove)-6 (r)3 (a)4 (l)-2 (l)-2 ( r)3 (e)4 (s)-1 (po)-10 (ns)-1 (e)4 ( r)3 (a)4 (t)-2 (e)4 ( i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (hos)-11 (e)4 ( t)-2 (um)-2 (or)3 (s)-1 ( t)-2 (e)4 (s)-1 (t)-2 (e)4 (d a)4 (s)-1 ( C)-3 (T)1 (A)2 ( 3)-10 (+)4 ( w)2 (a)4 (s)-1 ( 18%)3 ( w)2 (hi)-2 (l)-2 (e)4 ( i)-2 (n )]TJ -0.004 Tc 0.004 Tw T* [(t)-6 (h)-4 (o)-4 (s)-5 (e t)-6 (h)-4 (at)-6 ( t)-6 (es)-5 (t)-6 (ed)-4 ( as)-5 ( C)-7 (T)-3 (A )-12 (2)-3.9 (+,)-4 ( i)-6 (t)-6.1 ( w)-1.9 (as)-5 ( 6)-4 (%)-1 (. )]TJ EMC /Span <>BDC /TT1 1 Tf 0.004 Tc 0 Tw 14.04 0 0 14.04 94.1886 192.5186 Tm (16 )Tj EMC /Span <>BDC 0 Tc -0.002 Tw 3.846 0 Td [(HOW SU)4.1 (P)4.1 (P)4.2 (LI)-4.1 (ED)4 (/)-4 (S)9 (TOR)]TJ -0.004 Tc 0.002 Tw 10.726 0 Td [(AG)-3.7 (E)-3.7 ( AND H)-3.8 (A)-8.5 (NDL)-3.7 (I)-8.1 (NG )]TJ EMC /Span <>BDC 0.004 Tc 0 Tw -14.572 -2 Td [(16.)14.7 (1 )]TJ EMC /Span <>BDC 0 Tc 3.847 0 Td (Ho)Tj -0.001 Tc -0.01 Tw 1.274 0 Td [(w)-14.1 ( Su)-0.6 (p)-0.6 (p)8 (l)-5 (i)-5.1 (e)-1.4 (d )]TJ EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.012 Tw 12 0 0 12 94.1886 144.0386 Tm [(HE)-1 (R)-5 (Z)9 (UM)-3 (A \()1 (t)-4 (r)1 (a)2 (s)-3 (t)-4 (u)-2 (z)-8 (u)-2 (m)-4 (a)-8 (b)]TJ 0 Tc 0 Tw 10.42 0 Td [(-)3 (pkr)3 (b)]TJ 0.002 Tc -0.002 Tw [(\))5 ( f)5 (o)-8 (r )-5 (I)15 (n)2 (je)6 (c)6 (tio)2 (n)2 ( 4)2 (2)2 (0 )-8 (mg)12 (/v)2 (ia)6 (l is)1 ( s)1 (u)2 (p)2 (p)2 (lie)6 (d)2 ( in)2 ( a)6 ( mu)2 (ltip)2 (le)]TJ 0 Tc 0 Tw 22.64 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.33 0 Td [(d)-4 (o)-4 (s)-5 (e v)-4 (i)-6 (al)-6 ( as)-5 ( a )]TJ 0 Tc 0 Tw -33.39 -1.16 Td [(w)2 (hi)-2 (t)-2 (e)4 ( t)-2 (o pa)4 (l)-2 (e )-16 (y)20 (e)4 (l)-2 (l)-2 (ow)2 ( l)-22 (y)20 (op)-10 (hi)-2 (l)-2 (i)-2 (z)-6 (e)4 (d s)-1 (t)-2 (e)4 (r)3 (i)-2 (l)-2 (e)4 ( pow)2 (de)4 (r)3 (, unde)4 (r)3 ( va)4 (c)4 (uum)-2 (. E)-9 (a)4 (c)4 (h )-10 (c)4 (a)4 (r)3 (t)-2 (on )-10 (c)4 (ont)-2 (a)4 (i)-2 (ns)-1 ( one )]TJ 0.002 Tc -0.002 Tw T* [(mu)2 (ltip)2 (le)]TJ 0 Tc 0 Tw 3.34 0 Td [(-)3 (dos)-1 (e)4 ( vi)-2 (a)4 (l)-2 ( of)3 ( H)2 (E)-9 (R)-3 (Z)11 (U)2 (M)-1 (A )-8 (a)4 (nd one)4 ( vi)-2 (a)4 (l)-2 ( \()3 (2)-10 (0 m)-12 (L)21 (\))3 ( of )-7 (B)-3 (a)4 (c)4 (t)-2 (e)4 (r)3 (i)-2 (os)]TJ 0.002 Tc 0.008 Tw 23.98 0 Td [(ta)6 (tic)6 ( W)-4 (a)6 (te)6 (r )15 (f)5 (o)2 (r)5 ( I)15 (n)2 (je)-4 (c)6 (tio)2 (n )]TJ 0 Tc 0 Tw -27.32 -1.17 Td [(\()3 (B)7 (W)-6 (F)-4 (I)13 (\))-7 (, U)2 (S)-4 (P)-4 (, c)4 (ont)-2 (a)4 (i)-2 (ni)-2 (ng 1.1%)3 ( be)4 (nz)-16 (y)20 (l )]TJ -0.004 Tc 0.004 Tw 15.71 0 Td [(al)-6 (co)-4 (h)-4 (o)-4 (l )-16 (as)-5 ( a)-10 ( p)-4 (r)-1 (es)-5 (er)-1 (v)-14 (at)-6 (i)-6 (v)-3.9 (e. )]TJ EMC /Artifact <>BDC 0 Tc 0 Tw 3.29 -3.88 Td (31)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 32.1886 26.8386 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4582 0 obj <>>>/Resources 4535 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4583 0 obj <> endobj 4584 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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<004C>3.9 <0052>-3.1 <0051>9.1 <0003000B>-1.4 <002B>2.1 <0028>-12.5 <0035>7.4 <0015>-3 <0012>3.9 <0026>7.3 <00280033>-7.3 <0014>-3 <001A>-3 <00030055>10.7 <0044>1.2 <0057>3.9 <004C>3.9 <0052>-3 <00030095>-2.2 <00030015>-3.1 <00110013>9.1 <000C>-1.4 <00030044>1.2 <0056>6.5 <00030053>-3 <0048>1.2 <0055>-1.3 <0049>10.7 <0052>-3.1 <0055>-1.3 <0050>22 <0048>1.2 <0047>-3 <00030044>1.2 <0057>3.9 <00030044>1.2 <00030046>1.2 <0048>1.2 <0051>9.1 <0057>3.9 <0055>-1.4 <0044>1.2 <004F>3.9 <0003004F>3.9 <0044>1.3 <0045>-3.1 <0052>-3 <0055>-1.3 <0044>1.2 <0057>3.9 <0052>-3 <0055>-1.4 <005C>]TJ /TT0 1 Tf 0 Tc 42.217 0 Td (. )Tj EMC /Span <>BDC /TT1 1 Tf 0.004 Tc -0.004 Tw 14.04 0 0 14.04 92.6886 623.5176 Tm [(14.)14.7 (2 )]TJ EMC /Span <>BDC 3.847 0 Td [(M)7.8 (e)3.6 (t)3.6 (as)8.4 (t)3.6 (at)12.3 (ic )]TJ 0.001 Tc -0.003 Tw 4.744 0 Td [(B)1.3 (r)9.1 (e)0.6 (a)5.3 (s)-3.2 (t)0.7 ( C)13.6 (a)-3.2 (n)1.4 (c)0.6 (e)0.6 (r )]TJ EMC /P <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 12 0 0 12 92.6886 603.1176 Tm [(T)-3 (h)-4 (e s)-5 (af)-1 (et)-26 (y )6 (an)-4 (d)-4 ( ef)-11 (f)-1 (i)-6 (ca)-10 (c)-20 (y)16 ( o)-13.9 (f)-1 ( t)-6.1 (r)-1 (as)-4.9 (t)-6 (u)-4 (z)-10 (u)-4 (m)-6 (ab)-4 ( i)-6 (n)-4 ( t)-6 (r)-1 (eat)-6 (m)-6 (e)-10 (n)-4 (t)-6 ( o)-4 (f)-1 ( w)-2 (o)-4 (m)-6 (en)-4 ( w)-2 (i)-6 (t)-6 (h)-4 ( m)-6 (et)-6 (as)-5 (t)-6 (at)-6 (i)-6 (c b)-3.9 (r)-1 (eas)-5 (t )-15.9 (can)-4 (c)-10 (er)-1 ( w)-12 (er)-1 (e )]TJ 0 Tc 0 Tw 0 -1.16 TD [(s)-1 (t)-2 (udi)-2 (e)4 (d i)-2 (n a)4 ( r)3 (a)4 (ndom)-2 (i)-2 (z)-6 (e)4 (d, c)4 (ont)-2 (r)3 (ol)-2 (l)-2 (e)4 (d c)4 (l)-2 (i)-2 (ni)-2 (c)4 (a)4 (l)-2 ( t)-2 (r)3 (i)-2 (a)4 (l)-2 ( i)-2 (n)-10 ( c)4 (om)-2 (bi)-2 (na)4 (t)-2 (i)-2 (on w)2 (i)-2 (t)-2 (h c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( \()3 (S)-4 (t)-2 (ud)-20 (y)20 ( 5, )]TJ 0 -1.17 TD [(n = )4 (469 pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 (\))3 ( a)4 (nd )-10 (a)4 (n )-10 (ope)4 (n-)]TJ 0.002 Tc -0.002 Tw 12.17 0 Td [(la)6 (b)2 (e)6 (l s)1 (in)-8 (g)12 (le)6 ( a)-4 (g)2 (e)6 (n)2 (t c)-4 (li)]TJ 0 Tc 0 Tw [(ni)-2 (c)4 (a)4 (l)-2 ( t)-2 (r)3 (i)-2 (a)4 (l)-2 ( \()3 (S)-4 (t)-2 (ud)-10 (y)20 ( 6, n = )-6 (222 pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 (\))3 (. B)7 (ot)-2 (h )]TJ -12.17 -1.17 Td [(t)-2 (r)3 (i)-2 (a)4 (l)-2 (s)-1 ( s)-1 (t)-2 (udi)-2 (e)4 (d pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h m)-2 (e)4 (t)-2 (a)4 (s)-1 (t)-2 (a)4 (t)-2 (i)-2 (c)4 ( br)3 (e)4 (a)4 (s)-1 (t )-12 (c)4 (a)4 (nc)-6 (e)-6 (r)3 ( w)2 (hos)-1 (e)4 ( t)-2 (um)-2 (or)3 (s)-1 ( ove)4 (r)-7 (e)4 (x)-10 (pr)3 (e)4 (s)-1 (s)-1 ( t)-2 (he)4 ( H)2 (E)1 (R)-3 (2 pr)3 (ot)-2 (e)4 (i)-2 (n. )]TJ 0 -1.16 TD [(P)-4 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (e)4 (r)3 (e)4 ( e)4 (l)-2 (i)-12 (g)10 (i)-2 (bl)-2 (e)4 ( i)-2 (f)3 ( t)-12 (he)-6 (y)20 ( h)-10 (a)4 (d 2 or)3 ( 3 l)-2 (e)4 (v)-10 (e)4 (l)-2 (s)-1 ( of)3 ( o)-10 (ve)4 (r)3 (e)4 (x)-10 (pr)3 (e)4 (s)-1 (s)-1 (i)-2 (on \()3 (ba)4 (s)-1 (e)4 (d on )-10 (a)4 ( 0 t)-2 (o 3 s)-1 (c)4 (a)4 (l)-2 (e)4 (\))3 ( b)-20 (y )]TJ 0.002 Tc -0.002 Tw 0 -1.17 TD [(immu)2 (n)2 (o)2 (h)2 (is)1 (to)2 (c)6 (h)2 (e)6 (mic)6 (a)6 (l a)6 (s)1 (s)1 (e)6 (s)1 (s)1 (me)6 (n)2 (t o)2 (f)5 ( tu)2 (mo)2 (r)5 ( tis)1 (s)1 (u)2 (e)6 ( p)2 (e)6 (r)5 (f)5 (o)2 (r)5 (me)6 (d)2 ( b)-18 (y )12 (a)6 ( c)-4 (e)6 (n)2 (tr)4.9 (a)6.1 (l te)-3.9 (s)0.9 (tin)2.1 (g)11.9 ( la)6 (b)2 (. )]TJ EMC /P <>BDC /TT2 1 Tf 0 Tc 0 Tw 0 -1.67 TD [(P)1 (r)-1 (e)4 (v)4 (i)-2 (ous)-1 (l)-2 (y)4 ( U)2 (nt)-2 (r)-1 (e)4 (at)-2 (e)4 (d M)-7 (e)-6 (t)-2 (as)-1 (t)-2 (at)-2 (i)-2 (c)4 ( B)1 (r)-1 (e)4 (as)-1 (t)-2 ( C)-3 (anc)4 (e)4 (r)-1 ( \()13 (S)-10 (t)-2 (udy)4 ( 5\) )]TJ EMC /P <>BDC /TT0 1 Tf 0 -1.66 TD [(S)-4 (t)-2 (ud)-10 (y)30 ( 5 )-10 (w)2 (a)4 (s)-1 ( a)4 ( m)-2 (ul)-2 (t)-2 (i)-2 (c)4 (e)4 (nt)-2 (e)-6 (r)3 (, r)3 (a)4 (ndom)-2 (i)-2 (z)-6 (e)4 (d, ope)4 (n-)]TJ 0.002 Tc -0.002 Tw 18.37 0 Td [(la)6 (b)-8 (e)-4 (l c)6 (lin)2 (ic)6 (a)6 (l tr)5 (ia)6 (l c)6 (o)2 (n)2 (d)2 (u)2 (c)6 (te)6 (d)2 ( i)-10 (n)2 ( 4)2 (6)2 (9 )]TJ 0 Tc 0 Tw 14.4 0 Td [(w)2 (om)-2 (e)4 (n w)2 (i)-2 (t)-2 (h )]TJ -0.004 Tc 0.004 Tw -32.77 -1.17 Td [(m)-6 (et)-6 (as)-5 (t)-6 (at)-6 (i)-6 (c b)-4 (r)-1 (eas)-5 (t )-16 (can)-4 (c)-10 (er )-11 (w)-1.9 (h)-4 (o)-4 ( h)-4 (ad)-4 ( n)-4 (o)-4 (t)-6 ( b)-4 (een )-4 (p)-14 (r)-1 (ev)-4 (i)-6 (o)-14 (u)-4 (s)-5 (l)-16 (y)16 ( t)-6 (r)-1 (e)-10 (at)-6 (ed)-4 ( w)-2 (i)-6 (t)-6 (h)-3.9 ( ch)-4 (em)-6.1 (o)-3.9 (t)-16 (h)-4 (er)-1 (ap)-24 (y)16 ( f)-1 (o)-14 (r)-1 ( m)-6 (et)-6 (as)-5 (t)-6 (at)-6 (i)-6 (c )]TJ 0 -1.17 TD [(d)-4 (i)-6 (s)-5 (eas)-5 (e.)-4 ( T)-3 (u)-4 (m)-6 (o)-4 (r)-1 ( s)-5 (p)-4 (e)-10 (ci)-6 (m)-6 (en)-14 (s)-4.9 ( w)-2.1 (er)-0.9 (e t)-6 (es)-5 (t)-6 (ed )-14 (b)-24 (y )6 (I)9 (H)-2 (C)-7 ( \()-1 (C)-7 (l)-6 (i)-6 (n)-4 (i)-6 (cal)-6 ( T)-3 (r)-1 (i)-6 (al)-6 ( A)-2 (s)-5 (s)-5 (a)-20 (y)16 (,)-4 ( C)-7 (T)-3 (A)-2 (\) )-11 (an)-4 (d)-4 ( s)-5 (co)-4 (r)-1.1 (ed )-14 (as)-5 ( 0)-4 (,)-4 ( 1)-4 (+, )]TJ 0 Tc 0 Tw 0 -1.16 TD [(2+)4 (, or)3 ( 3+)4 (, w)2 (i)-2 (t)-2 (h 3+)4 ( i)-2 (ndi)-2 (c)-6 (a)-6 (t)-2 (i)-2 (ng)10 ( t)-2 (he)4 ( s)-1 (t)-2 (r)3 (on)-10 (g)10 (e)4 (s)-1 (t)-2 ( pos)-1 (i)-2 (t)-2 (i)-2 (vi)-2 (t)-12 (y)20 (. O)2 (nl)-22 (y)20 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h 2+ )-6 (or)3 ( 3+)4 ( pos)-1 (i)-2 (t)-2 (i)-2 (ve)4 ( t)-2 (um)-2 (or)3 (s )]TJ -0.004 Tc 0.014 Tw 0 -1.17 TD [(w)-2 (er)-1 (e el)-6 (i)-6 (g)6 (i)]TJ 0 Tc 0 Tw 3.96 0 Td [(bl)-2 (e )-6 (\()3 (a)4 (bout)-2 ( 33%)-7 ( of)3 ( t)-2 (hos)-1 (e)4 ( s)-1 (c)4 (r)3 (e)-6 (e)4 (ne)4 (d)-10 (\))3 (. P)-4 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (e)4 (r)3 (e)4 ( r)-7 (a)4 (ndom)-2 (i)-2 (z)-6 (e)4 (d t)-2 (o r)3 (e)4 (c)4 (e)4 (i)-2 (ve )-6 (c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)-7 (a)4 (p)-20 (y )]TJ -3.96 -1.17 Td [(a)4 (l)-2 (one)4 ( or)3 ( i)-2 (n c)4 (om)-2 (bi)-2 (na)4 (t)-2 (i)-2 (on )-10 (w)2 (i)-2 (t)-2 (h t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b g)10 (i)-2 (ve)4 (n i)-12 (nt)-2 (r)3 (a)4 (ve)4 (nous)-1 (l)-22 (y)20 ( a)4 (s)-1 ( a)4 ( 4 m)-12 (g)10 (/)-2 (k)-10 (g)10 ( l)-2 (oa)4 (di)-2 (n)-10 (g)10 ( dos)-1 (e )]TJ 0 -1.16 TD [(f)3 (ol)-2 (l)-2 (ow)2 (e)4 (d b)-20 (y)20 ( w)2 (e)-6 (e)4 (kl)-12 (y)20 ( dos)-11 (e)-6 (s)-1 ( of)3 ( t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b a)4 (t)-2 ( 2 m)-2 (g)10 (/)-12 (kg)10 (. )-10 (F)6 (or)3 ( t)-2 (hos)-1 (e)4 ( w)2 (ho h)-10 (a)4 (d r)3 (e)-6 (c)4 (e)4 (i)-2 (ve)4 (d pr)3 (i)-2 (or )]TJ 0 -1.17 TD [(a)4 (nt)-2 (hr)3 (a)4 (c)-16 (y)20 (c)4 (l)-2 (i)-2 (n)-10 (e)4 ( t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( i)-2 (n t)-12 (he)4 ( a)4 (dj)-2 (uva)4 (nt)-2 ( s)-1 (e)4 (t)-2 (t)-2 (i)-2 (ng)10 (, )-10 (c)4 (he)4 (m)-12 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( c)4 (ons)-1 (i)-2 (s)-1 (t)-2 (e)4 (d of)3 ( p)-10 (a)4 (c)-6 (l)-2 (i)-2 (t)-2 (a)4 (x)-10 (e)4 (l)-2 ( \()3 (175 )]TJ 0.002 Tc -0.002 Tw [(mg)12 (/m)]TJ EMC /StyleSpan <>BDC 0 Tc 0 Tw 8.04 0 0 8.04 545.9286 399.7176 Tm (2 )Tj EMC /P <>BDC 12 0 0 12 92.6886 381.1176 Tm [(ove)4 (r)3 ( 3 hour)3 (s)-1 ( e)4 (v)-10 (e)4 (r)-17 (y)20 ( 21 )]TJ -0.004 Tc 0.004 Tw [(d)-4 (a)-10 (y)16 (s)-15 ( f)-1 (o)-14 (r)-1 ( at)-6 ( l)-6 (eas)-5 (t)-6 ( s)-5 (i)-6 (x)-14 ( c)-10 (y)16 (cl)-16 (es)-5.1 (\))-1 (;)-16 ( f)-0.9 (o)-4 (r)-1 ( al)-6 (l)-6 ( o)-4 (t)-6 (h)-4 (er)-1 ( p)-4 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 (, )-14 (ch)-4 (e)-10 (m)-6 (o)-4 (t)-6 (h)-4 (er)-1 (ap)-24 (y)16 ( co)-4 (n)-4 (s)-5 (i)-6 (s)-5 (t)-6 (ed )]TJ 0 Tc 0 Tw 0 -1.16 TD [(of)3 ( a)4 (nt)-2 (hr)3 (a)-6 (c)-16 (y)20 (c)4 (l)-2 (i)-2 (ne)4 ( pl)-2 (us)-1 ( c)-16 (y)20 (c)-6 (l)-2 (ophos)-1 (pha)4 (m)-2 (i)-2 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This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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S)-4 (t)-2 (ud)-10 (y )]TJ -0.004 Tc 0.004 Tw 12.73 0 Td [(2)-4 (, )-14 (w)-2 (h)-4 (er)-11 (e c)-10 (en)-4 (t)-6 (r)-1 (al)-6 ( l)-6 (a)-10 (b)-4 (o)-4 (r)-1 (at)-6 (o)-4 (r)-21 (y)16 ( t)-6 (es)-5.1 (t)-5.9 (i)-6.1 (n)-3.9 (g)6 ( d)-14 (at)-6 (a w)-12 (er)-11 (e av)-4 (ai)-6 (l)-6 (ab)-4 (l)-6 (e. )]TJ 0 Tc 0 Tw -12.73 -1.17 Td [(T)1 (he )4 (r)3 (e)4 (s)-1 (ul)-2 (t)-2 (s)-1 ( a)4 (r)-7 (e)4 ( s)-1 (how)2 (n i)-2 (n )]TJ -0.004 Tc 0.004 Tw 10.03 0 Td [(T)-3 (ab)-4 (l)-6 (e )]TJ 0 Tc 0 Tw [(8. T)1 (he)4 ( num)-2 (be)-6 (r)3 ( of)3 ( e)-6 (ve)4 (nt)-2 (s)-1 ( i)-2 (n S)-4 (t)-2 (ud)-10 (y )]TJ 0.002 Tc -0.002 Tw 16.12 0 Td [(2 )-8 (w)4 (a)6 (s)1 ( s)1 (ma)-4 (ll w)4 (ith)2 ( th)2 (e)6 ( e)6 (x)-8 (c)6 (e)6 (p)2 (tio)2 (n )]TJ 0 Tc 0 Tw -26.15 -1.16 Td [(of)3 ( t)-2 (he )-6 (I)13 (H)2 (C )-3 (3+)4 (/)-12 (F)-4 (I)23 (S)-14 (H)2 (+)4 ( s)-1 (u)-10 (bg)10 (r)3 (oup, )-10 (w)2 (hi)-2 (c)4 (h c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (e)-6 (d 81%)3 ( of)3 ( t)-2 (hos)-1 (e)4 ( w)2 (i)-2 (t)-2 (h da)4 (t)-2 (a)4 (.)-10 ( D)2 (e)4 (f)3 (i)-2 (ni)-2 (t)-2 (i)-2 (ve )]TJ T* [(c)4 (onc)4 (l)-2 (us)-1 (i)-2 (ons)-1 ( c)4 (a)4 (nnot)-2 ( be)4 ( dr)-7 (a)4 (w)2 (n r)3 (e)-6 (ga)4 (r)3 (di)-2 (n)-10 (g)10 ( e)4 (f)-7 (f)3 (i)-2 (c)4 (a)-6 (c)-16 (y)20 ( w)-8 (i)-2 (t)-2 (hi)-2 (n ot)-2 (he)4 (r)3 ( s)-1 (ubg)10 (r)3 (oups)-1 ( due)-6 ( t)-2 (o t)-2 (h)]TJ 0.002 Tc -0.002 Tw [(e)6 ( s)1 (ma)6 (ll n)2 (u)2 (mb)2 (e)6 (r )]TJ 0 Tc 0 Tw T* [(of)3 ( e)4 (ve)4 (nt)-2 (s)-1 (. )]TJ EMC /P <>BDC /TT1 1 Tf 0 -2.16 TD [(T)-3 (ab)-4 (l)-2 (e )4 (8:)]TJ /T1_0 1 Tf (\003 )Tj /TT1 1 Tf -0.004 Tc 0.004 Tw 6 0 Td [(T)-7 (rea)-4 (t)-11 (m)9 (en)-8 (t)-1 ( O)-6 (u)-8 (t)-11 (co)-14 (m)9 (es)-5 ( i)-6 (n)-18 ( S)-8 (t)-1 (u)-7.9 (d)]TJ 0 Tc 0 Tw 12.43 0 Td [(y 2 as)-1 ( a F)11 (u)-4 (n)-4 (c)4 (t)3 (i)-2 (on)-4 ( of)-7 ( H)-2 (E)-3 (R)2 (2 O)-2 (ve)4 (r)4 (e)4 (xp)-4 (r)4 (e)4 (s)-1 (s)-1 (i)-2 (on)-4 ( or )]TJ 0.002 Tc -12.43 -1.17 Td [(A)-6 (m)15 (p)-2 (lif)-5 (ic)6 (a)2 (t)5 (io)2 (n )]TJ EMC /TH <>BDC -0.002 Tc 0.002 Tw 11.04 0 0 11.04 370.4766 285.8786 Tm [(St)-6 (udy)-2 ( 2 )]TJ EMC /TD <>BDC 0.002 Tc -0.002 Tw -23.065 -1.935 Td [(H)-2.6 (E)5.9 (R)6.7 (2)2 ( A)6.6 (ssa)2 (y)2 ( R)17.4 (esu)3.6 (l)8.3 (t)]TJ 0 Tc 0 Tw 6.96 0 0 6.96 208.2366 268.4786 Tm (a )Tj EMC /TD <>BDC 0.004 Tc -0.015 Tw 11.04 0 0 11.04 264.158 264.5186 Tm [(N)8.6 (u)5.7 (mb)5.6 (e)2.4 (r )-8.7 (o)14.9 (f P)-4.6 (a)14.9 (ti)-0.6 (e)2.4 (n)16.5 (ts )]TJ EMC /TD <>BDC 0 Tc 0 Tw 12.239 0 Td [(H)-4.6 (az)9.2 (ar)-1.6 (d)1.6 ( R)4.6 (at)6.9 (i)-4.6 (o D)15.5 (F)-8.6 (S)1.7 ( \()-4 (9)10.9 (5% )]TJ -0.005 Tc 0.005 Tw 10.739 0 Td [(CI)-7.3 (\) )]TJ EMC /TD <>BDC /TT0 1 Tf -0.007 Tc 0.007 Tw -37.739 -1.935 Td [(IH)-2.4 (C)-3 ( 3)-7 (+ )]TJ EMC /TD <>BDC -0.002 Tc 0.002 Tw 1 -2.337 Td [(FI)15.7 (SH)2.6 ( \()-6 (+)-3.2 (\) )]TJ EMC /TD <>BDC 0 Tc 0 Tw 16.913 0 Td (1170 )Tj EMC /TD <>BDC 14.304 0.587 Td (0.42 )Tj -1.457 -1.152 Td [(\()-4 (0.27, 0.)10.9 (64\) )]TJ EMC /TD <>BDC /C2_0 1 Tf -0.002 Tc 0.002 Tw -29.76 -2.337 Td [<0029002C>15.7 <0036002B0003>0.6 <000B>-6 <00ED>-3.2 <000C0003>]TJ EMC /TD <>BDC /TT0 1 Tf 0 Tc 0 Tw 17.413 0 Td (51 )Tj EMC /TD <>BDC 13.804 0.587 Td (0.71 )Tj -1.707 -1.152 Td [(\()-4 (0.04, 1)10.9 (1.79\) )]TJ EMC /TD <>BDC -0.005 Tc 0.005 Tw -29.51 -2.337 Td [(F)-3.3 (I)12.7 (S)-3.3 (H Un)-15.9 (k)5.9 (n)-5 (o)-5 (wn )]TJ EMC /TD <>BDC 0 Tc 0 Tw 17.413 0 Td (51 )Tj EMC /TD <>BDC 13.804 0.587 Td (0.69 )Tj -1.457 -1.152 Td [(\()-4 (0.09, 5.)10.9 (14\) )]TJ EMC /TD <>BDC 0.001 Tc -0.001 Tw -30.76 -1.75 Td [(I)7.9 (H)5.6 (C)5 ( < 3)1 (+ / )]TJ -0.018 Tc 0.018 Tw 0 -1.163 TD [(F)-27.2 (IS)-16.4 (H )]TJ 0.001 Tc -0.001 Tw 2.402 0 Td [(\()-3 (+\) )]TJ EMC /TD <>BDC 0 Tc 0 Tw 15.761 0.576 Td (174 )Tj EMC /TD <>BDC 14.054 0.587 Td (1.01 )Tj -1.457 -1.163 Td [(\()-4 (0.18, 5.)10.9 (65\) )]TJ EMC /Artifact <>BDC 12 0 0 12 323.4366 65.4386 Tm (28 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 33.4366 36.7986 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS1 gs /Fm0 Do Q EMC endstream endobj 4597 0 obj <>>>/Resources 4532 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4598 0 obj <> endobj 4599 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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-1.66 Td ( )Tj 34.25 0 Td ( )Tj 0.002 Tc -0.002 Tw -35.14 -1.17 Td ( )Tj 9.3 0 Td [( )-2750 ( )]TJ 15.08 0 Td ( )Tj 11.25 0 Td ( )Tj -0.004 Tc 0.004 Tw -28.99 -1.17 Td ( )Tj 0 Tc 0 Tw 21.56 -1.16 Td ( )Tj -22.2 -2.34 Td [( )-560 ( )-1510 ( )]TJ 0.002 Tc -0.002 Tw 11.04 0 Td ( )Tj 0 Tc 0 Tw 1.76 0 Td ( )Tj 0.002 Tc -0.002 Tw 3.6 0 Td ( )Tj 7.22 0 Td ( )Tj 0 Tc 0 Tw 0.26 0 Td ( )Tj 3.25 -1.66 Td ( )Tj /C2_0 1 Tf -0.004 Tc -32.37 -1.17 Td <0003>Tj 7.18 0 Td [<0003>-3244 <0003>-3904 <0003>-1674 <0003>]TJ /TT0 1 Tf 0 Tc 14.7 0 Td ( )Tj /C2_0 1 Tf -0.004 Tc 6.86 0 Td <0003>Tj /TT0 1 Tf 0 Tc -26.09 -1.17 Td ( )Tj 13.44 0 Td ( )Tj 13.2 0 Td [( )-2670 ( )]TJ -23.94 -1.16 Td ( )Tj -0.004 Tc 0.004 Tw 20.25 0 Td ( )Tj 0 Tc 0 Tw 1.59 0 Td ( )Tj -21.84 -1.17 Td [( )-440 ( )-4120 ( )]TJ 0.002 Tc -0.002 Tw 11.4 0 Td ( )Tj 17.15 0 Td ( )Tj 0 Tc 0 Tw -27.56 -1.17 Td ( )Tj 6.49 0 Td [( )-1550 ( )]TJ 8.94 0 Td ( )Tj 0.002 Tc -0.002 Tw 13.25 0 Td ( )Tj 0 Tc 0 Tw -25.78 -1.16 Td ( )Tj 12.41 0 Td ( )Tj 8.48 0 Td ( )Tj -20.83 -1.17 Td ( )Tj 20.65 0 Td ( )Tj /TT2 1 Tf -15.02 -1.17 Td ( )Tj /TT0 1 Tf 19.31 0 Td ( )Tj -23.84 -1.16 Td ( )Tj 24.38 0 Td ( )Tj -22.88 -1.17 Td ( )Tj 22.66 0 Td ( )Tj -22.27 -1.17 Td ( )Tj 22.1 0 Td ( )Tj -17.72 -1.16 Td ( )Tj 12.97 0 Td [( )-3510 ( )]TJ -23.03 -1.17 Td ( )Tj -4.42 -1.67 Td ( )Tj 23.32 0 Td ( )Tj 8.25 0 Td ( )Tj -31.69 -1.16 Td ( )Tj /C2_0 1 Tf 31.88 0 Td <0003>Tj /TT0 1 Tf -23.61 -2.34 Td ( )Tj /C2_0 1 Tf 15.53 0 Td <0003>Tj 7.35 0 Td <0003>Tj /TT0 1 Tf -32.22 -1.16 Td ( )Tj 15.78 0 Td ( )Tj -0.004 Tc 0.004 Tw -15.77 -1.17 Td [( )-4639.9 ( )]TJ 0 Tc 0 Tw 31.5 0 Td ( )Tj -29.5 -1.17 Td ( )Tj 13.2 0 Td ( )Tj 17.02 0 Td ( )Tj EMC /P <>BDC 0 Tr -37.12 51.85 Td [(A)2 ( f)3 (e)4 (r)3 (t)-2 (i)-2 (l)-2 (i)-2 (t)-12 (y)20 ( s)-1 (t)-2 (ud)-20 (y)20 ( w)2 (a)4 (s )-11 (c)4 (on)-10 (duc)4 (t)-2 (e)4 (d i)-2 (n f)3 (e)4 (m)-2 (a)4 (l)-2 (e)4 ( C)-23 (y)20 (nom)-12 (ol)-2 (g)10 (us)-1 ( m)-2 (onke)-16 (y)20 (s)-1 ( a)4 (t)-2 ( dos)-1 (e)4 (s)-1 ( u)-10 (p t)-2 (o 25 )]TJ 0.002 Tc -0.002 Tw [(time)6 (s)1 ( th)2 (e )]TJ -0.004 Tc 0.004 Tw 0 -1.16 TD [(w)-2 (eek)-4 (l)-26 (y )]TJ 0 Tc 0 Tw 3.13 0 Td [(r)3 (e)-6 (c)4 (om)-2 (m)-2 (e)4 (nde)4 (d hu)-10 (m)-2 (a)4 (n dos)-1 (e)4 ( of)3 ( 2 m)-12 (g)10 (/)-2 (kg)10 ( o)-10 (f)3 ( t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b a)4 (nd ha)4 (s)-1 ( r)3 (e)4 (v)]TJ -0.004 Tc 0.004 Tw 26.38 0 Td [(e)-10 (al)-6 (ed)-4 ( n)-4 (o)-4 ( ev)-4 (i)-6 (d)-4 (en)-14 (ce o)-4 (f )]TJ -29.51 -1.17 Td [(i)-6 (m)-6 (p)-4 (ai)-6 (r)-1 (ed)-4 ( f)-1 (er)-1 (t)-6 (i)-6 (l)-6 (i)-6 (t)-16 (y)16 (, )-14 (as)-5 ( m)-6 (ea)-9.9 (s)-5 (u)-4 (r)-1 (ed)-4 ( b)-24 (y)16 ( m)-6 (en)-4 (s)-5 (t)-6 (r)-1 (u)-4 (al)-6 ( c)-20 (y)16 (c)-10 (l)-6 (e )-10 (d)-4 (u)-4 (r)-1 (at)-6 (i)-6 (o)-4 (n)-4 ( an)-4 (d)-4 ( f)-1 (em)-16 (al)-6 (e s)-5 (ex)-14 ( h)-4 (o)-3.9 (r)-1 (m)-6.1 (o)-4 (n)-4 (e l)-6 (ev)-4 (el)-6 (s)-5 (. )]TJ EMC /Span <>BDC /TT1 1 Tf 0.004 Tc 0 Tw 14.04 0 0 14.04 92.6827 657.8887 Tm (14 )Tj EMC /Span <>BDC -0.004 Tc 0.002 Tw 3.846 0 Td [(CL)-3.6 (I)-8.2 (NI)-8.2 (CAL)-3.6 ( S)-3.6 (T)-3.6 (UDIE)-3.7 (S )]TJ EMC /Span <>BDC 0.004 Tc 0 Tw -3.846 -2 Td [(14.)14.7 (1 )]TJ EMC /Span <>BDC -0.004 Tc 0.002 Tw 3.847 0 Td [(Ad)-3.5 (j)-4.3 (u)-3.6 (v)-8.3 (an)-3.5 (t)-4.4 ( B)-3.7 (r)-4.4 (e)4.1 (a)-8.3 (st)-4.4 ( Can)-3.5 (c)-4.5 (e)-4.4 (r )]TJ EMC /P <>BDC /TT0 1 Tf 0.004 Tw 12 0 0 12 92.6827 609.4088 Tm [(T)-3 (h)-4 (e s)-5 (af)-1 (et)-26 (y )6 (an)-4 (d)-4 ( ef)-11 (f)-1 (i)-6 (ca)-10 (c)-20 (y)16 ( o)-13.9 (f)-1 ( t)-6.1 (r)-1 (as)-4.9 (t)-6 (u)-4 (z)-10 (u)-4 (m)-6 (ab)-4 ( i)-6 (n)-4 ( w)-2 (o)-4 (m)-6 (en)-4 ( r)-1 (ecei)-6 (v)-4 (i)-6 (n)-14 (g)6 ( ad)-4 (j)-6 (u)-4 (v)-14 (an)-4 (t)-6 ( ch)-4 (em)-16 (o)-4 (t)-6 (h)-4 (er)-0.9 (ap)-24.1 (y)16 ( f)-1 (o)-4 (r )-11 (H)-2 (E)-3 (R)-7 (2 )]TJ 0 -1.17 TD [(o)-4 (v)-4 (er)-1 (ex)-14 (p)-4 (r)-1 (es)-5 (s)-5 (i)-6 (n)-4 (g)6 ( b)-14 (r)-1 (e)-10 (as)-5 (t)-6 ( ca)-10 (n)-4 (cer)-1 ( w)-12 (er)-0.9 (e )-10 (ev)-4 (al)-6 (u)-4 (at)-16 (ed)-4 ( i)-6 (n)-4 ( an)-14 ( i)-6 (n)-4 (t)-6 (eg)6 (r)-11 (at)-6 (ed)-4 ( an)-14 (al)-16 (y)16 (s)-5 (i)-6 (s)-5 ( o)-4 (f)-1 ( t)-6 (w)-12 (o)-4 ( r)-1 (an)-4 (d)-4 (o)-4 (m)-6 (i)-6 (z)-9.9 (ed)-4 (, )]TJ 0 Tc 0 Tw 0 -1.16 TD [(ope)4 (n-)]TJ 0.002 Tc -0.002 Tw 2.27 0 Td [(la)6 (b)2 (e)6 (l,)2 ( c)6 (lin)2 (ic)-4 (a)6 (l tr)5 (ia)6 (ls)1 ( \()5 (S)-2 (tu)2 (d)2 (ie)6 (s )]TJ 0 Tc 0 Tw 11.42 0 Td [(1 a)4 (nd 2\))3 ( w)2 (i)-2 (t)-2 (h a)4 ( t)-2 (ot)-2 (a)4 (l)-2 ( of)3 ( 4063 w)2 (om)-2 (e)4 (n a)4 (t)-2 ( t)-2 (h)-10 (e)4 ( pr)3 (ot)-2 (oc)4 (ol)-2 (-)]TJ -0.004 Tc 0.004 Tw 20.9 0 Td [(s)-5 (p)-4 (e)-10 (ci)-6 (f)-1 (i)-6 (ed )]TJ 0 Tc 0 Tw -34.59 -1.17 Td [(f)3 (i)-2 (na)4 (l)-2 ( ove)4 (r)3 (a)4 (l)-2 (l)-2 ( s)-1 (ur)3 (vi)-2 (va)4 (l )-12 (a)4 (na)-6 (l)-12 (y)20 (s)-1 (i)-2 (s)-1 (, a)4 ( t)-2 (hi)-2 (r)3 (d r)3 (a)4 (ndom)-2 (i)-2 (z)-6 (e)4 (d,)-10 ( ope)4 (n-)]TJ 0.002 Tc -0.002 Tw 22.63 0 Td [(la)6 (b)2 (e)6 (l,)2 ( c)6 (lin)2 (ic)-4 (a)6 (l tr)5 (ia)6 (l \()5 (S)-2 (tu)2 (d)-8 (y )22 (3)2 (\))5 ( w)4 (ith)2 ( a)6 ( to)2 (ta)6 (l )]TJ 0 Tc 0 Tw -22.63 -1.17 Td [(of)3 ( 3386 )]TJ 0.002 Tc -0.002 Tw [(w)4 (o)2 (me)6 (n)2 ( a)6 (t d)2 (e)-4 (f)5 (in)2 (itiv)2 (e)6 ( D)4 (is)1 (e)6 (a)6 (s)1 (e)]TJ 0 Tc 0 Tw 14.68 0 Td [(-)-7 (F)6 (r)-7 (e)4 (e)4 ( S)-4 (ur)3 (vi)-2 (va)-6 (l)-2 ( a)4 (na)4 (l)-12 (y)20 (s)-1 (i)-2 (s)-1 ( f)3 (o)-10 (r)3 ( one)4 (-)]TJ 0.002 Tc -0.002 Tw 12.68 0 Td [(y)22 (e)-4 (a)6 (r)5 ( tr)-5 (a)-4 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b)2 ( tr)5 (e)6 (a)6 (tme)6 (n)2 (t )]TJ 0 Tc 0 Tw -27.36 -1.16 Td [(ve)4 (r)3 (s)-1 (us)-1 ( obs)-1 (e)4 (r)3 (v)-10 (a)4 (t)-2 (i)-2 (on, a)4 (nd a)-6 ( f)3 (our)3 (t)-2 (h r)3 (a)4 (ndom)-2 (i)-2 (z)-6 (e)4 (d, ope)4 (n)-10 (-)]TJ 0.002 Tc -0.002 Tw 20.55 0 Td [(la)6 (b)2 (e)6 (l c)6 (lin)2 (ic)6 (a)6 (l tr)5 (ia)6 (l w)4 (ith)2 ( a)-4 ( to)2 (ta)6 (l o)2 (f)5 ( 3)2 (2)2 (2)2 (2 )2 (p)2 (a)6 (tie)6 (n)2 (ts )]TJ -0.003 Tc 0.003 Tw -20.55 -1.17 Td [(\(S)-7 (t)-5 (u)-3 (d)-13 (y )17 (4)-3 (\). )]TJ EMC /P <>BDC /TT2 1 Tf 0 Tc 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(i)-6 (z)-10 (at)-6 (i)-6 (o)-4 (n)-4 ( \()-1 (S)-8 (t)-6 (u)-4 (d)-14 (y)26 ( 2)-14 (\) )-10.9 (o)-4 (r)-1 ( w)-2.1 (as)-4.9 ( r)-11 (eq)-4 (u)-4 (i)-6 (r)-1 (ed)-4 ( t)-6 (o)-4 ( b)-4 (e p)-14 (er)-11 (f)-1 (o)-4 (r)-1 (m)-6 (ed)-4 ( at)-6 ( a )-10 (r)-1 (ef)-11 (er)-1 (en)-14 (ce l)-6 (a)]TJ 0 Tc 0 Tw [(b)-10 (or)3 (a)4 (t)-2 (or)-17 (y)20 ( \()3 (S)-4 (t)-2 (ud)-20 (y)20 ( 1\))3 (. )]TJ 0 -1.16 TD [(P)-4 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h a)4 ( hi)-2 (s)-1 (t)-2 (or)-7 (y)20 ( of)-7 ( a)4 (c)4 (t)-2 (i)-2 (ve)4 ( c)-6 (a)4 (r)3 (di)-2 (a)4 (c)4 ( di)-2 (s)-1 (e)-6 (a)4 (s)-1 (e)4 ( b)-10 (a)-6 (s)-1 (e)4 (d on s)-11 (y)20 (m)-2 (pt)-2 (om)-2 (s)-1 (, a)4 (bnor)-7 (m)-2 (a)4 (l )]TJ 0 -1.17 TD [(e)4 (l)-2 (e)4 (c)4 (t)-2 (r)3 (oc)-6 (a)4 (r)3 (di)-2 (o)-10 (g)10 (r)-7 (a)4 (phi)-2 (c)4 (, r)3 (a)4 (d)-10 (i)-2 (ol)-2 (og)10 (i)-2 (c)4 (, or)3 ( l)-2 (e)-6 (f)3 (t)-2 ( ve)4 (nt)-2 (r)3 (i)-2 (c)4 (ul)-2 (a)-6 (r)3 ( e)4 (j)-2 (e)4 (c)4 (t)-2 (i)-2 (on f)3 (r)-7 (a)4 (c)4 (t)-2 (i)-2 (on f)3 (i)-2 (ndi)-2 (n)-10 (g)10 (s)-1 ( or)3 ( un)-10 (c)4 (ont)-2 (r)3 (ol)-2 (l)-2 (e)4 (d )]TJ T* [(h)-10 (y)20 (pe)-6 (r)3 (t)-2 (e)4 (ns)-1 (i)-2 (on \()3 (di)-2 (a)4 (s)-1 (t)-2 (ol)-2 (i)-2 (c )4 (> )-6 (100 )]TJ 0.002 Tc -0.002 Tw [(mm H)4 (g)12 ( o)2 (r)5 ( s)-19 (y)22 (s)1 (to)2 (lic)6 ( > )-4 (2)2 (0)2 (0 )2 (mm H)4 (g)12 (\) )5 (w)-6 (e)6 (r)5 (e)6 ( n)2 (o)2 (t )-10 (e)6 (lig)12 (ib)2 (le)6 (. )]TJ EMC /P <>BDC 0 Tc 0 Tw 0 -1.66 TD [(P)-4 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (e)4 (r)3 (e)4 ( r)-7 (a)4 (ndom)-2 (i)-2 (z)-6 (e)4 (d \()3 (1:)-2 (1\))3 ( t)-2 (o r)3 (e)4 (c)-6 (e)4 (i)-2 (ve)4 ( dox)-10 (or)3 (ubi)-2 (c)4 (i)-2 (n a)4 (nd c)-16 (y)20 (c)4 (l)-2 (ophos)-1 (pha)4 (m)-12 (i)-2 (de)4 ( f)3 (ol)-2 (l)-2 (ow)2 (e)4 (d b)-20 (y )]TJ /C2_0 1 Tf -0.004 Tc 0.004 Tw 0 -1.17 TD [<0053>-4 <00440046004F>-6 <004C>-6 <0057>-6 <0044005B>-14 <0048004F0003>-10 <000B>-1 <0024>-2 <0026>-7 <013A>-4 <0053>-4 <00440046004F>-6 <004C>-6 <0057>-6 <0044005B>-3.9 <0048004F>-6 <000C0003>-4.9 <0044004F>-6 <0052>-4 <0051>-4 <00480003>-4 <0052>-4 <00550003>-5 <0053>-14 <00440046004F>-6 <004C>-6 <0057>-6 <0044005B>-14 <0048004F0003>-10 <0053>-4 <004F>-6 <0058>-4 <00560003>]TJ /TT0 1 Tf 0.002 Tc 0 Tw 20.88 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ /C2_0 1 Tf -0.004 Tc 0.004 Tw 5.14 0 Td [<000B>-1 <0024>-2 <0026>-7 <013A>-4 <0053>-4 <00440046004F>-6 <004C>-6 <0057>-6 <0044005B>-14 <0048004F0003>-10 <000E0003>]TJ /TT0 1 Tf 0.002 Tc -0.002 Tw -26.02 -1.17 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b)]TJ -0.023 Tc 0.033 Tw 4.89 0 Td [(\))-20 (.)-23 ( In )]TJ 0 Tc 0 Tw 1.9 0 Td [(bot)-2 (h t)-2 (r)3 (i)-2 (a)-6 (l)-2 (s)-1 (, pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( r)3 (e)4 (c)4 (e)4 (i)-2 (ve)4 (d )-10 (f)3 (our )-7 (21-)]TJ -0.02 Tc 0.02 Tw 14.78 0 Td [(d)-20 (a)-36 (y c)-36 (yc)-16 (l)-32 (e)-16 (s)-21 ( o)]TJ 0 Tc 0 Tw 4.94 0 Td [(f)3 ( dox)-10 (or)3 (ubi)-2 (c)4 (i)-2 (n 60 )]TJ 0.002 Tc -0.002 Tw [(mg)12 (/m)]TJ EMC 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T)1 (r)3 (a)-6 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b )]TJ 0.002 Tc -0.002 Tw [(tr)5 (e)6 (a)6 (tme)6 (n)2 (t )]TJ 0 Tc 0 Tw -25.79 -1.17 Td [(w)2 (a)4 (s)-1 ( pe)4 (r)3 (m)-2 (a)4 (n)-10 (e)4 (nt)-2 (l)-12 (y)20 ( di)-2 (s)-1 (c)4 (ont)-2 (i)-12 (nue)4 (d i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (ho de)4 (v)-10 (e)4 (l)-2 (ope)4 (d c)4 (on)-10 (g)10 (e)4 (s)-1 (t)-2 (i)-2 (ve)4 ( h)-10 (e)4 (a)4 (r)3 (t)-2 ( f)-7 (a)4 (i)-2 (l)-2 (ur)3 (e)4 (, or )]TJ -0.004 Tc 0.014 Tw T* [(p)-4 (er)-1 (s)-5 (i)-6 (s)-5 (t)-6 (en)-4 (t)-6 (/)-6 (r)-1 (ecu)-4 (r)-11 (r)-1 (en)-4 (t)-6 ( L)7.1 (V)-2 (E)]TJ 0.004 Tw 9.91 0 Td [(F)2 ( d)-4 (ecl)-6 (i)-6 (n)-4 (e )]TJ /TT2 1 Tf [([)-5 (s)-15 (ee D)-2 (o)-4 (s)-5 (a)-4 (g)-14 (e )]TJ 0 Tc 0 Tw [(an)-10 (d A)1 (dm)2 (i)-2 (ni)-2 (s)-1 (t)-2 (r)-1 (at)-2 (i)-2 (on \()13 (2.3)]TJ -0.033 Tc 0.033 Tw 18.76 0 Td (\)])Tj /TT0 1 Tf 0 Tc 0 Tw 0.73 0 Td [(. )10 (R)-3 (a)4 (di)-2 (a)4 (t)-2 (i)-2 (on t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 (, i)-2 (f )]TJ 0.002 Tc -0.002 Tw -29.4 -1.16 Td [(a)6 (d)2 (min)2 (is)1 (te)6 (r)5 (e)6 (d)2 (,)2 ( w)4 (a)6 (s)1 ( in)2 (itia)6 (te)6 (d)2 ( a)6 (f)5 (te)-4 (r)5 ( th)2 (e )]TJ 0 Tc 0 Tw 14.54 0 Td [(c)4 (om)-2 (pl)-2 (e)4 (t)-2 (i)-2 (on o)-10 (f)3 ( c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)-7 (a)4 (p)-20 (y)20 (. P)-4 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h E)1 (R)-3 (+)4 ( a)4 (nd/)-2 (or)3 ( P)-4 (R)-3 (+ )]TJ -14.54 -1.17 Td [(t)-2 (um)-2 (or)3 (s)-1 ( r)3 (e)4 (c)4 (e)4 (i)-2 (ve)4 (d ho)-10 (r)3 (m)-2 (ona)-6 (l)-2 ( t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 (. 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This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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0.72 re f 72 378.96 0.72 31.44 re f 72 378.24 0.72 0.72 re f 72 378.24 0.72 0.72 re f 72.72 378.24 112.92 0.72 re f 185.64 378.96 0.72 31.44 re f 185.64 378.24 0.72 0.72 re f 186.36 378.24 62.28 0.72 re f 248.64 378.96 0.72 31.44 re f 248.64 378.24 0.72 0.72 re f 249.36 378.24 91.44 0.72 re f 340.8 378.96 0.72 31.44 re f 340.8 378.24 0.72 0.72 re f 341.52 378.24 87.12 0.72 re f 428.64 378.96 0.72 31.44 re f 428.64 378.24 0.72 0.72 re f 429.36 378.24 100.319 0.72 re f 529.68 378.96 0.72 31.44 re f 529.68 378.24 0.72 0.72 re f 529.68 378.24 0.72 0.72 re f q 1 0 0 1 -21.698883 -16.838623 cm BT /TT0 1 Tf 3 Tr 9.96 0 0 9.96 191.2571 385.7186 Tm ( )Tj -9.506 -1.145 Td ( )Tj /C2_0 1 Tf -0.001 Tc 25.204 0 Td [<0003>-3558.1 <0003>-1003.9 <0003>]TJ 13.168 0 Td [<0003>-847.4 <0003>]TJ 7.144 0 Td <0003>Tj 0.004 Tc -40.902 -1.157 Td <0003>Tj /TT0 1 Tf 0 Tc 4.916 0 Td ( )Tj -9.494 -1.156 Td ( )Tj 0.002 Tc 0.001 Tw 32.75 0 Td ( )Tj 0.006 Tc -0.003 Tw 11.683 0 Td ( )Tj 0 Tc 0 Tw -38.964 -1.157 Td [( )-3 ( )]TJ -5.505 -1.156 Td ( )Tj -0.006 Tc 0.009 Tw 15.434 0 Td ( )Tj 0.006 Tc -0.003 Tw 7.361 0 Td ( )Tj 12.952 0 Td ( )Tj 0 Tc 0 Tw 1.096 0 Td ( )Tj /C2_0 1 Tf 0.002 Tc -31.916 -1.157 Td <0003>Tj /TT0 1 Tf 0 Tc 2.397 0 Td ( )Tj -7.288 -1.144 Td ( )Tj 0.002 Tc 0.001 Tw 10.58 0 Td ( )Tj 33.003 0 Td ( )Tj 0 Tc 0 Tw -26.029 -1.157 Td ( )Tj -17.59 -1.156 Td [( )-3557 ( )]TJ 9.373 0 Td ( )Tj -9.445 -1.157 Td ( )Tj /C2_0 1 Tf 0.006 Tc 2.578 0 Td [<0003>-4707.8 <0003>-4852.3 <0003>]TJ 19.554 0 Td [<0003>-4816.3 <0003>-3840.2 <0003>-3695.9 <0003>-828.3 <0003>-3840.3 <0003>-1659.7 <0003>]TJ 0.002 Tc -17.445 -1.157 Td [<0003>-4687.8 <0003>-3833.2 <0003>-1447.1 <0003>-4519.9 <0003>-1663.6 <0003>-4917.1 <0003>]TJ /TT0 1 Tf 0 Tc 25.771 0 Td ( )Tj -30.362 -1.144 Td ( )Tj 22.373 0 Td ( )Tj 12 0 0 12 93.6989 228.2786 Tm ( )Tj ET Q EMC 1 0 0 1 -21.698883 -16.838623 cm BT /P <>BDC /TT1 1 Tf 12 0 0 12 93.6989 725.4386 Tm [(T)-3 (ab)-4 (l)-2 (e )4 (7: )-1407 (E)-3 (f)3 (f)-7 (i)-2 (c)4 (ac)4 (y R)2 (e)4 (s)-1 (u)-4 (l)-2 (t)3 (s)-1 ( f)-7 (r)4 (om)13 ( A)-8 (d)-4 (j)3 (u)-4 (van)-4 (t)3 ( T)-3 (r)4 (e)4 (at)-7 (m)13 (e)4 (n)-4 (t)3 ( of)-7 ( B)-3 (r)4 (e)4 (as)-1 (t)3 ( C)2 (an)-4 (c)-6 (e)4 (r)4 ( \()3 (S)-4 (t)3 (u)-4 (d)-4 (i)-2 (e)4 (s)-1 ( 1 )-10 (+ 2 an)-4 (d )]TJ 0.004 Tc -0.004 Tw 5.19 -1.17 Td [(St)7 (udy)4 ( 4)4 (\) )]TJ EMC /TH <>BDC -0.005 Tc 0 Tw 11.04 0 0 11.04 228.6951 676.2343 Tm [(DF)-13.6 (S )]TJ 0.002 Tc -0.38 -1.152 Td [(ev)2 (en)3.6 (t)9 (s )]TJ EMC /TH <>BDC -0.002 Tc -0.009 Tw 5.685 2.293 Td [(D)2.6 (F)-10.6 (S H)-6.6 (a)-2 (z)7.2 (a)-2 (r)-3.7 (d )]TJ -0.006 Tc 0 Tw 1.652 -1.141 Td [(r)-7.6 (a)-6 (t)-10 (io )]TJ 0 Tc -0.979 -1.141 Td [(\()-4 (95%)10.9 ( C)4.6 (I)-2.3 (\) )]TJ 0.424 -1.163 Td [(p)2 (-)-4 (val)-4.6 (u)12.5 (e )]TJ EMC /TH <>BDC -0.005 Tc 8.261 2.304 Td [(De)-6.7 (a)-5 (t)-8.9 (h)-3.4 (s )]TJ 0.002 Tc -0.013 Tw -0.989 -1.152 Td [(\()-2 (O)-2.6 (S)3.7 ( ev)2 (en)14.6 (t)-2 (s\) )]TJ EMC /TH <>BDC 0 Tc 0 Tw 7.456 1.152 Td [(O)-4.6 (S)1.6 ( H)6.3 (az)9.2 (ar)-1.6 (d)1.6 ( r)-1.6 (at)6.9 (i)-4.6 (o )]TJ 1.967 -1.152 Td [(p)2 (-)-4 (val)-4.6 (u)12.5 (e )]TJ EMC /TD <>BDC /TT0 1 Tf -34.803 -2.902 Td [(S)1.7 (t)-4.7 (udi)6.3 (e)-1.6 (s)-2.4 ( 1 )10.9 (+)-1.2 ( 2)]TJ 6.96 0 0 6.96 157.4189 635.4386 Tm (a )Tj EMC /TD <>BDC /C2_0 1 Tf -0.005 Tc 11.04 0 0 11.04 99.4589 612.1586 Tm [<00240026>-1 <013A>-5 <0037>-13.6 <002B0003>]TJ /TT0 1 Tf 0 Tc 0 -1.152 TD [(\()-4 (n =)-1.2 ( 18)10.9 (72\))]TJ 6.96 0 0 6.96 146.1389 603.3986 Tm (b )Tj 11.04 0 0 11.04 99.4531 586.7205 Tm [(\()-4 (n =)-1.2 ( 20)10.9 (31\))]TJ 6.96 0 0 6.96 146.1389 590.6786 Tm (c )Tj EMC /TD <>BDC 11.04 0 0 11.04 229.1789 599.3152 Tm (133)Tj 6.96 0 0 6.96 245.7389 603.2786 Tm (b )Tj EMC /TD <>BDC 11.04 0 0 11.04 301.9018 612.1581 Tm (0.48)Tj 0.009 Tw 6.96 0 0 6.96 321.2189 616.1186 Tm [(b,)-8.6 ( d )]TJ 0 Tw 11.04 0 0 11.04 291.0979 599.4405 Tm [(\()-4 (0.39, 0.)10.9 (59\) )]TJ 0.163 -1.152 Td [(p<)-1.2 ( 0.0001)]TJ 6.96 0 0 6.96 337.6589 590.6786 Tm (e )Tj EMC /TD <>BDC 11.04 0 0 11.04 396.9408 599.3152 Tm (289)Tj 6.96 0 0 6.96 413.4989 603.2786 Tm (c )Tj EMC /TD <>BDC 11.04 0 0 11.04 486.4594 612.1581 Tm (0.64)Tj -0.009 Tc 0.018 Tw 6.96 0 0 6.96 505.7789 616.1186 Tm [(c)-13.3 (, d )]TJ 0 Tc 0 Tw 11.04 0 0 11.04 475.4194 599.4405 Tm [(\()-4 (0.55, 0.)10.9 (74\) )]TJ 0.163 -1.152 Td [(p<)-1.2 ( 0.0001)]TJ 6.96 0 0 6.96 521.9789 590.6786 Tm (e )Tj EMC /TD <>BDC /C2_0 1 Tf -0.005 Tc 11.04 0 0 11.04 99.4589 567.3986 Tm [<00240026>-1 <013A>-5 <00370003>]TJ /TT0 1 Tf 0 Tc 0 -1.141 TD [(\()-4 (n =)-1.2 ( 18)10.9 (80\))]TJ 6.96 0 0 6.96 146.1389 558.7586 Tm (b )Tj 11.04 0 0 11.04 99.4546 542.0805 Tm [(\()-4 (n =)-1.2 ( 20)10.9 (32\))]TJ 6.96 0 0 6.96 146.1389 546.0386 Tm (c )Tj EMC /TD <>BDC 11.04 0 0 11.04 229.1789 554.6752 Tm (261)Tj 6.96 0 0 6.96 245.7389 558.6386 Tm (b )Tj EMC /TD <>BDC 11.04 0 0 11.04 396.9451 554.6786 Tm (418)Tj 6.96 0 0 6.96 413.4989 558.6386 Tm (c )Tj EMC /TD <>BDC 11.04 0 0 11.04 99.4589 522.6386 Tm [(S)1.7 (t)-4.7 (udy)10.9 ( 4)]TJ 6.96 0 0 6.96 133.4189 526.5986 Tm (f )Tj EMC /TD <>BDC -0.004 Tc 11.04 0 0 11.04 99.4589 497.0787 Tm [(T)-12.6 (CH )]TJ 0 Tc 0 -1.163 TD [(\()-4 (n =)-1.2 ( 10)10.9 (75\) )]TJ EMC /TD <>BDC 11.902 0.576 Td (134 )Tj EMC /TD <>BDC 6.913 1.152 Td (0.67 )Tj -1.707 -1.141 Td [(\()-4 (0.54 \226 )11 (0.84\) )]TJ 0.217 -1.163 Td [(p=)-1.2 (0.0006)]TJ -0.013 Tc 0.013 Tw 6.96 0 0 6.96 332.8589 481.8386 Tm (e, )Tj 0 Tc 0 Tw 0.948 0 Td (g )Tj EMC /TD <>BDC 11.04 0 0 11.04 401.2536 490.5967 Tm (56 )Tj EMC /TD <>BDC /C2_0 1 Tf -0.005 Tc -27.336 -3.467 Td [<00240026>-1 <013A>-5 <0037>-13.6 <002B0003>]TJ /TT0 1 Tf 0 Tc 0 -1.152 TD [(\()-4 (n =)-1.2 ( 10)10.9 (74\) )]TJ EMC /TD <>BDC 11.902 0.565 Td (121 )Tj EMC /TD <>BDC 6.913 1.163 Td (0.60 )Tj -1.707 -1.152 Td [(\()-4 (0.48 \226 )11 (0.76\) )]TJ 0.152 -1.152 Td [(p<)-1.2 ( 0.0001)]TJ 0.004 Tc -0.004 Tw 6.96 0 0 6.96 334.7789 437.1986 Tm (e, )Tj 0 Tc 0 Tw 0.966 0 Td (f )Tj EMC /TD <>BDC 11.04 0 0 11.04 401.2546 445.8352 Tm (49 )Tj EMC /TD <>BDC /C2_0 1 Tf -0.005 Tc -27.337 -2.891 Td [<00240026>-1 <013A>-5 <00370003>]TJ /TT0 1 Tf 0 Tc T* [(\()-4 (n =)-1.2 ( 10)10.9 (73\) )]TJ EMC /TD <>BDC 11.902 0.576 Td (180 )Tj EMC /TD <>BDC 15.435 0 Td (80 )Tj EMC /P <>BDC 0.002 Tc 0.001 Tw 9.96 0 0 9.96 93.6989 385.7186 Tm [(C)6.4 (I)-2.4 ( = co)-4 (n)8 (f)9.7 (i)2.9 (d)-4 (e)-11.8 (n)8 (ce i)2.9 (n)8 (t)2.9 (er)-14.4 (v)8.1 (al )]TJ EMC /StyleSpan <>BDC 0 Tc 0 Tw 6.48 0 0 6.48 93.6989 377.7987 Tm (a )Tj EMC /P <>BDC 0.006 Tc -0.003 Tw 9.96 0 0 9.96 99.0988 374.3186 Tm [(S)7.8 (t)6.9 (u)12 (di)6.8 (e)4.3 (s)9.4 ( 1 a)4.2 (n)12 (d 2 r)1.6 (e)4.2 (g)12.1 (i)-5.2 (m)12.9 (e)4.2 (ns)9.5 (:)6.8 ( dox)12 (or)1.6 (u)12 (bi)6.9 (c)4.2 (i)6.9 (n)12 ( a)-7.8 (n)12 (d )]TJ /C2_0 1 Tf -0.001 Tc 0.001 Tw [<0046>-14.8 <005C>17.1 <0046>-2.8 <004F0052>-7 <0053>-7 <004B>5 <0052>-7 <0056>2.4 <0053>-19.1 <004B>5.1 <0044>-14.9 <0050>5.9 <004C0047>-7 <00480003>-6.8 <0049>6.7 <0052>-7.1 <004F004F0052>-19.1 <005A>22.2 <0048>-2.8 <00470003>-11 <0045>-19.1 <005C0003>13.1 <0053>-7.1 <0044>-2.8 <0046>-2.8 <004F004C00570044>-14.9 <005B>5.1 <0048>-2.8 <004F0003>-4 <000B>-17.5 <0024>-1.9 <0026>3.4 <013A>-1 <0037>-16.5 <000C0003>-9.4 <0052>-7 <00550003>2.6 <0053>-7 <0044>-2.8 <0046>-2.8 <004F004C00570044>-2.8 <005B>5 <0048>-2.8 <004F0003>-4 <0053>-7 <004F0058>5 <00560003>]TJ 0.004 Tc -0.004 Tw -0.542 -1.157 Td [<0057>4.9 <00550044>2.2 <0056>7.5 <0057>4.9 <0058>10 <005D>-9.8 <0058>-2.1 <0050>11 <0044>2.2 <00450003>-1.1 <000B0024>3.1 <0026>8.4 <013A>3.9 <0037>-11.5 <002B>3.1 <000C00110003>]TJ EMC /StyleSpan <>BDC /TT0 1 Tf 0 Tc 0 Tw 6.48 0 0 6.48 93.6989 354.7586 Tm (b )Tj EMC /P <>BDC 0.002 Tc 0.001 Tw 9.96 0 0 9.96 99.4588 351.2786 Tm [(E)-1.5 (f)9.7 (f)9.7 (i)2.9 (cac)-11.9 (y)8 ( e)-11.8 (v)8 (al)2.9 (u)8.1 (ab)-4 (l)2.8 (e p)-4.1 (o)-4 (p)-4 (u)8 (l)2.9 (at)2.9 (i)2.9 (o)-16.1 (n)8 (,)-1 ( f)9.7 (o)-4 (r)-2.4 ( t)2.9 (h)8.1 (e p)-4.1 (r)-2.3 (i)-9.2 (m)21 (ar)-14.4 (y)8 ( D)1.1 (F)-8.2 (S)3.8 ( an)8 (al)-9.2 (y)8.1 (s)5.4 (i)-9.1 (s)5.4 (,)-1 ( f)9.7 (o)-4 (l)2.9 (l)2.8 (o)-16 (w)13.1 (i)-9.1 (n)8 (g)8 ( a )-12 (m)8.9 (ed)-4 (i)2.9 (an )-4.1 (f)9.8 (o)-4.1 (l)2.9 (l)2.9 (o)-16.1 (w)]TJ 0 Tc 0 Tw 35.373 0 Td (-)Tj 0.006 Tc -0.003 Tw 0.337 0 Td [(u)12 (p of)13.7 ( 2.)3 (0 y)24.1 (e)4.2 (a)4.2 (r)1.7 (s)9.4 ( i)-5.2 (n)12.1 ( t)-5.2 (h)12 (e )]TJ /C2_0 1 Tf 0.001 Tc 0 Tw -36.289 -1.157 Td [<00240026>5.4 <013A>1 <0037>-14.5 <002B0003>-2 <0044>-0.8 <0055>-15.4 <0050>]TJ /TT0 1 Tf 0 Tc 5.542 0 Td (. )Tj EMC /StyleSpan <>BDC 6.48 0 0 6.48 93.6989 331.7186 Tm (c )Tj EMC /P <>BDC -0.006 Tc 0.009 Tw 9.96 0 0 9.96 99.0988 328.2387 Tm [(E)-9.5 (f)1.7 (f)1.7 (i)-5.1 (c)-7.7 (a)-7.8 (c)-19.9 (y e)-19.9 (va)-7.8 (l)-5.1 (ua)-7.8 (b)-12 (l)-5.1 (e)-7.8 ( p)-12 (o)-12 (p)-12 (ul)-5.1 (a)-7.8 (t)-5.1 (i)-5.1 (o)-24.1 (n,)-9 ( f)1.7 (o)-12 (r)-10.3 ( t)-5.1 (he )-19.9 (f)1.8 (i)-17.2 (na)]TJ 0.006 Tc -0.003 Tw 17 0 Td [(l)6.9 ( O)5.1 (S)7.8 ( a)-7.8 (n)12 (a)4.2 (l)-5.1 (y)12 (s)9.4 (i)6.9 (s)9.5 (, )-9.1 (f)13.7 (o)-12.1 (l)6.9 (l)6.9 (o)-12.1 (w)29.2 (i)-5.1 (ng)12 ( 707 de)4.2 (a)4.2 (t)6.9 (h)12 (s)9.5 ( \()1.6 (8.)3 (3 y)24.1 (e)4.2 (a)4.2 (r)1.7 (s )-2.6 (of )]TJ -0.001 Tc 0.004 Tw 19.855 0 Td [(m)17.9 (e)-2.7 (d)-7.1 (ia)-14.8 (n)5 ( f)6.7 (o)-7.1 (llo)-19.1 (w)]TJ 0 Tc 0 Tw 5.807 0 Td (-)Tj -0.006 Tc 0.009 Tw 0.337 0 Td [(up)-12 ( i)-17.2 (n )]TJ EMC /P <>BDC /C2_0 1 Tf 0.002 Tc -0.002 Tw -43.542 -1.157 Td [<0057>2.9 <004B>8 <00480003>-13 <0024>13.1 <0026>-5.7 <013A>2 <0037>-13.5 <002B000300440055>-2.3 <0050>20.9 <000C>-2.3 <00110003>]TJ EMC /StyleSpan <>BDC /TT0 1 Tf 0 Tc 0 Tw 6.48 0 0 6.48 93.6989 308.7987 Tm (d )Tj EMC /P <>BDC 0.002 Tc 0.001 Tw 9.96 0 0 9.96 99.4588 305.3186 Tm [(H)1.1 (azar)-2.4 (d)-4 ( r)-2.4 (at)2.9 (i)2.9 (o)-4 ( es)5.5 (t)2.9 (i)2.8 (m)21 (a)-11.8 (t)2.9 (ed)-4 ( b)-4.1 (y )8 (C)-5.7 (o)-4 (x)8 ( r)-2.3 (eg)8 (r)-2.3 (es)5.4 (s)5.5 (i)2.9 (o)-16.1 (n)8 ( s)5.5 (t)2.9 (r)-2.4 (at)2.9 (i)-9.1 (f)9.7 (i)2.9 (ed)-4 ( b)-16 (y)20 ( cl)2.8 (i)-9.1 (n)-4 (i)2.9 (cal)2.9 ( t)2.9 (r)-2.4 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This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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)-16 (d)-4 (o)-4 (cet)-6 (ax)-14 (el)-6 ( 1)-4 (0)-4 (0 )]TJ 0.002 Tc -0.002 Tw 8.86 0 Td [(mg)12 (/m)]TJ EMC /StyleSpan <>BDC 0 Tc 0 Tw 8.04 0 0 8.04 309.1688 570.1686 Tm (2 )Tj EMC /P <>BDC -0.004 Tc 0.004 Tw 12 0 0 12 316.2488 565.6086 Tm [(w)-2 (as)-5 ( ad)-4 (m)-6 (i)-6 (n)-4 (i)-6 (s)-5 (t)-6 (er)-1 (ed)-4 ( ev)-4 (e)-10 (r)-21 (y)16 ( 3 )]TJ 0 Tc 0 Tw 10.43 0 Td [(w)-8 (e)4 (e)4 (ks)-1 ( f)3 (or )-7 (f)3 (our)3 ( c)-16 (y)20 (c)4 (l)-12 (e)4 (s)-1 (. )-10 (I)13 (n )]TJ -0.004 Tc 0.004 Tw -29.04 -1.17 Td [(t)-6 (h)-4 (e T)-3 (C)-7 (H)-2 ( ar)-1 (m)-6 (,)-4 ( d)-4 (o)-4 (cet)-16 (ax)-14 (el)-6 ( 7)-4 (5 )]TJ 0.002 Tc -0.002 Tw 11.11 0 Td [(mg)12 (/m)]TJ EMC /StyleSpan <>BDC 0 Tc 0 Tw 8.04 0 0 8.04 254.2088 556.1286 Tm (2 )Tj EMC /P <>BDC -0.004 Tc 0.004 Tw 12 0 0 12 261.2888 551.5686 Tm [(an)-4 (d)-4 ( car)-1 (b)-4 (o)-4 (p)-4 (l)-6 (at)-6 (i)-16 (n)-4 ( \()-1 (at)-6 ( a t)-6 (ar)-10.9 (g)-4 (et)-6.1 ( A)-1.9 (U)-2 (C)-7 ( o)]TJ -0.003 Tc 0.003 Tw 13.82 0 Td (f 6 )Tj 0.002 Tc -0.002 Tw 1.34 0 Td [(mg)12 (/m)-10 (L)23 (/min)2 ( a)6 (s )-9 (a)6 ( 3)2 (0)]TJ 0 Tc 0 Tw 7.8 0 Td [(-)-247 (t)-2 (o )]TJ -36.99 -1.16 Td [(60-)3 (m)-2 (i)-2 (nut)-2 (e)4 ( i)-2 (nf)3 (us)-1 (i)-2 (on\) )]TJ -0.004 Tc 0.004 Tw 8.22 0 Td [(w)-2 (er)-1 (e)-10 ( ad)-4 (m)-6 (i)-6 (n)-4 (i)-6 (s)-5 (t)-6 (er)-1 (ed)-4 ( ev)-4 (e)-10 (r)-21 (y)16 ( 3 )-3.9 (w)-2 (e)-10 (ek)-4 (s)-5.1 ( f)-0.9 (o)-4.1 (r)-0.9 ( s)-5.1 (i)-6 (x)-13.9 ( c)-10.1 (y)16 (cl)-16 (es)-5 (.)-3.9 ( T)-3 (r)-1 (as)-5 (t)-6 (u)-14 (z)-10 (u)-4 (m)-6 (ab )-4 (w)-2 (as )]TJ 0.002 Tc -0.002 Tw -8.22 -1.17 Td [(a)6 (d)2 (min)2 (is)1 (te)6 (r)5 (e)6 (d)2 ( w)4 (e)-4 (e)6 (k)2 (l)-10 (y )12 (\()5 (in)2 (itia)6 (l )]TJ 0 Tc 0 Tw [(dos)-1 (e)4 ( of)3 ( 4 m)-2 (g)10 (/)-2 (k)-10 (g)10 ( f)3 (ol)-2 (l)-2 (o)-10 (w)2 (e)4 (d b)-20 (y)20 ( w)2 (e)-6 (e)4 (kl)-12 (y)20 ( dos)-11 (e)4 ( of)3 ( 2 )]TJ -0.004 Tc 0.004 Tw 30.3 0 Td [(m)-6 (g)6 (/)-6 (k)-14 (g)6 (\))-1 ( co)-4 (n)-14 (cu)-4 (r)-1 (r)-11 (en)-4 (t)-6 (l)-16 (y )]TJ 0 Tc 0 Tw -30.3 -1.17 Td [(w)2 (i)-2 (t)-2 (h e)4 (i)-2 (t)-2 (he)4 (r)3 ( T)1 ( or)3 ( T)1 (C)-3 (, a)4 (nd )-10 (t)-2 (he)4 (n e)4 (ve)4 (r)-17 (y)20 ( 3 )-10 (w)2 (e)4 (e)4 (ks )-11 (\()3 (6 )]TJ 0.002 Tc -0.002 Tw [(mg)12 (/k)-8 (g)]TJ 0 Tc 0 Tw 21.54 0 Td [(\))3 ( a)4 (s)-1 ( m)-2 (onot)-2 (he)-6 (r)3 (a)4 (p)-20 (y)20 ( f)3 (o)-10 (r)-7 ( a)4 ( t)-2 (ot)-2 (a)4 (l)-2 ( of)3 ( 52 )]TJ -0.004 Tc 0.004 Tw [(w)-2 (eek)-4 (s)-5 (. )]TJ 0.002 Tc -0.002 Tw -21.54 -1.16 Td [(R)-1 (a)6 (d)2 (ia)6 (tio)2 (n)2 ( th)2 (e)6 (r)5 (a)6 (p)-18 (y)22 (,)2 ( if)5 ( a)6 (d)2 (m)-10 (in)2 (is)1 (te)6 (r)5 (e)6 (d)2 (,)2 ( w)4 (a)6 (s)1 ( in)2 (itia)6 (te)6.1 (d)2 ( a)5.9 (f)-5 (te)6.1 (r)5 ( c)6 (o)2 (mp)2 (le)6 (tio)2 (n)2 ( o)2 (f)5 ( c)6 (h)-8 (e)6 (mo)2 (th)2 (e)6 (r)5 (a)6 (p)-18 (y)22 (.)2 ( P)-2 (a)6 (tie)6 (n)2 (ts)1 ( w)4 (ith )]TJ -0.004 Tc 0.004 Tw T* [(E)-3 (R)-7 (+ an)-4 (d)-4 (/)-6 (o)-4 (r)-1 ( P)-8 (R)-7 (+ )]TJ 0 Tc 0 Tw (t)Tj -0.004 Tc 0.004 Tw 7.21 0 Td [(u)-4 (m)-6 (o)-4 (r)-1 (s)-5 ( r)-1 (ecei)-6 (v)-14 (ed)-4 ( h)-4 (o)-4 (r)-1 (m)-6 (o)-4 (n)-4 (al)-6 ( t)-6 (h)-3.9 (er)-11 (ap)-14 (y)16 (.)-14 ( D)-2 (i)-6 (s)-5 (e)-10 (as)-5 (e)]TJ 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 17.41 0 Td [(F)2 (r)-11 (ee S)-8 (u)-4 (r)-1 (v)-4 (i)-6 (v)-4 (al )-16 (\()-1 (D)-2 (F)2 (S)-8 (\))-1 ( w)-12 (as)-5 ( t)-6 (h)-3.9 (e m)-6.1 (ai)-5.9 (n )]TJ -24.62 -1.17 Td [(o)-4 (u)-4 (t)-6 (co)-4 (m)-6 (e m)-6 (eas)-5 (u)-4 (r)-11 (e. )]TJ EMC /P <>BDC 0 Tc 0 Tw 0 -1.66 TD [(A)2 (m)-2 (ong)10 ( t)-2 (he )4 (3222 p)-10 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( r)3 (a)4 (ndom)-2 (i)-2 (z)-6 (e)4 (d, t)-2 (he)4 ( m)-2 (e)4 (di)-2 (a)4 (n )-10 (a)4 (ge)4 ( w)2 (a)4 (s)-1 ( 49 )-10 (\()3 (r)3 (a)4 (n)-10 (ge)4 ( 22 t)-2 (o )-10 (74 )]TJ -0.003 Tc 0.003 Tw 31.26 0 Td [(y)17 (e)-9 (a)1 (rs)-4 (;)-5 ( 6)-3 (% )]TJ /C2_0 1 Tf 0 Tc 0 Tw -31.26 -1.17 Td <00950003>Tj /TT0 1 Tf 0.8 0 Td [(65 )-10 (y)20 (e)-6 (a)4 (r)3 (s)-1 (\))3 (. D)2 (i)-2 (s)-11 (e)4 (a)4 (s)-1 (e )-6 (c)4 (ha)4 (r)-7 (a)4 (c)4 (t)-2 (e)4 (r)3 (i)-2 (s)-1 (t)-2 (i)-2 (c)4 (s)-1 ( i)-2 (nc)4 (l)-2 (ude)4 (d 54)-10 (% )-7 (E)1 (R)-3 (+)4 ( a)4 (nd/)-2 (or)3 ( P)-4 (R)-3 (+)4 ( a)4 (nd 71)-10 (%)3 ( node)4 ( pos)-1 (i)-2 (t)-2 (i)-2 (ve)4 (. P)-4 (r)3 (i)-2 (or )]TJ -0.8 -1.17 Td [(t)-2 (o r)3 (a)4 (ndom)-2 (i)-2 (z)-6 (a)4 (t)-2 (i)-2 (on, a)4 (l)-2 (l)-2 ( pa)4 (t)-2 (i)8 (e)4 (nt)-2 (s)-1 ( unde)4 (r)3 (w)2 (e)4 (nt)-2 ( p)-10 (r)3 (i)-2 (m)-2 (a)4 (r)-17 (y)20 ( s)-11 (ur)3 (ge)4 (r)-17 (y)20 ( f)3 (o)-10 (r)3 ( br)3 (e)-6 (a)4 (s)-1 (t)-2 ( c)4 (a)4 (n)-10 (c)4 (e)4 (r)3 (. )]TJ EMC /P <>BDC -0.004 Tc 0.004 Tw T* [(T)-3 (h)-4 (e r)-1 (es)-5 (u)-4 (l)-6 (t)-6 (s )]TJ 0 Tc 0 Tw 4.66 0 Td [(f)3 (or)3 ( D)-8 (F)6 (S)-4 ( f)3 (or)3 ( t)-12 (he)4 ( i)-2 (nt)-2 (e)4 (gr)3 (a)4 (t)-2 (e)4 (d )-10 (a)4 (na)4 (l)-22 (y)20 (s)-1 (i)-2 (s)-1 ( of )-7 (S)-4 (t)-2 (udi)-2 (e)4 (s )-1 (1 a)4 (nd 2 a)4 (nd S)-4 (t)-2 (udy )10 (4 a)4 (nd )-10 (O)2 (S)-4 ( r)3 (e)4 (s)-1 (ul)-2 (t)-2 (s)-1 ( f)3 (or )]TJ -4.66 -1.17 Td [(t)-2 (he)4 ( i)-2 (nt)-2 (e)4 (g)10 (r)-7 (a)4 (t)-2 (e)4 (d a)4 (n)-10 (a)4 (l)-22 (y)20 (s)-1 (i)-2 (s)-1 ( of)-7 ( S)-4 (t)-2 (udi)-2 (e)4 (s)-1 ( 1 a)4 (nd 2 a)4 (r)3 (e)4 ( pr)-7 (e)4 (s)-1 (e)-6 (nt)-2 (e)4 (d i)-2 (n )]TJ -0.004 Tc 0.004 Tw [(T)-3 (ab)-4 (l)-6 (e )]TJ 0 Tc 0 Tw [(7. F)6 (o)-10 (r)3 ( S)-4 (t)-2 (udi)-2 (e)4 (s )-1 (1 a)4 (nd 2, t)-2 (he )]TJ 0 -1.17 TD [(dur)3 (a)4 (t)-2 (i)-2 (on of)3 ( D)2 (F)6 (S)-4 ( f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (n)-10 (g)10 ( a)4 ( m)-12 (e)4 (di)-2 (a)4 (n f)3 (ol)-2 (l)-2 (ow)2 (-)]TJ /C2_0 1 Tf 17.71 0 Td [<005800530003005200490003>-7 <0015001100130003>-10 <005C>20 <0048>-6 <0044>4 <0055>3 <0056>-1 <0003004C>-2 <005100030057>-2 <004B0048>4 <00030024>2 <0026>-3 <013A0037>1 <002B>-8 <00030044>4 <0055>3 <00500003>]TJ /TT0 1 Tf 14.47 0 Td [(i)-2 (s)-1 ( pr)3 (e)4 (s)-1 (e)4 (nt)-2 (e)4 (d i)-2 (n )]TJ -0.01 Tc 0.01 Tw -32.18 -1.16 Td [(F)-4 (i)-12 (gu)-20 (r)-7 (e )]TJ 0 Tc 0 Tw 2.85 0 Td [(3, )-10 (a)4 (nd t)-2 (he)4 ( dur)3 (a)4 (t)-2 (i)-2 (o)-10 (n of)3 ( O)2 (S)-4 ( a)4 (f)3 (t)-2 (e)4 (r )-7 (a)4 ( m)-2 (e)4 (di)-2 (a)4 (n f)3 (o)-10 (l)-2 (l)-2 (ow)2 (-)]TJ /C2_0 1 Tf 19.28 0 Td [<00580053000300520049>3 <0003001B001100160003>-10 <005C>20 <0048>-6 <0044>-6 <0055>3 <0056>-1 <0003004C>-2 <005100030057>-2 <004B0048>4 <00030024>2 <0026>-3 <013A0037>1 <002B0003>]TJ /TT0 1 Tf 0.002 Tc -0.002 Tw 12.66 0 Td [(a)6 (r)5 (m is )]TJ -0.004 Tc 0.004 Tw -34.79 -1.17 Td [(p)-4 (r)-1 (es)-5 (en)-4 (t)-6 (ed)-4 ( i)-6 (n )-14 (F)2 (i)-6 (g)6 (u)-14 (r)-1 (e )]TJ 0 Tc 0 Tw [(4. T)1 (h)-10 (e)4 ( dur)3 (a)4 (t)-2 (i)-2 (on of)3 ( D)-8 (F)6 (S)-4 ( f)3 (or)3 ( S)-4 (t)-2 (ud)-10 (y )20 (4 i)-2 (s)-1 ( pr)3 (e)4 (s)-11 (e)4 (nt)-2 (e)4 (d i)-2 (n F)6 (i)-12 (g)10 (ur)-7 (e )4 (5. A)2 (c)4 (r)3 (os)-1 (s )-11 (a)4 (l)-2 (l)-2 ( f)3 (our )]TJ 0.002 Tc -0.002 Tw T* [(s)1 (tu)2 (d)2 (ie)6 (s)1 (,)2 ( a)6 (t th)2 (e)6 ( time)6 ( o)2 (f)5 ( d)2 (e)6 (f)-5 (in)2 (itiv)2 (e)6 ( D)4 (F)8 (S)-2 ( a)6 (n)2 (a)6 (l)-20 (y)32 (s)1 (is)1 (,)2 ( th)2 (e)-4.1 (r)-5 (e)6.1 ( w)3.9 (e)6.1 (r)-5 (e)6 ( in)1.9 (s)1.1 (u)2 (f)5 (f)5 (ic)5.9 (ie)6 (n)2.1 (t n)1.9 (u)2 (mb)-8 (e)6.1 (r)5 (s)0.9 ( o)2 (f)5 ( p)2 (a)6.1 (tie)6 (n)2 (ts)0.9 ( w)4 (ith)2.1 (in )]TJ 0 -1.16 TD [(e)6 (a)6 (c)6 (h)2 ( o)2 (f)5 ( th)-8 (e)6 ( f)5 (o)2 (llo)2 (w)4 (in)-8 (g)12 ( s)1 (u)2 (b)2 (g)12 (r)5 (o)2 (u)2 (p)2 (s)1 ( to)2 ( d)2 (e)6 (t)-10 (e)6 (r)5 (min)2 (e)6 ( if)5 ( th)-8.1 (e)6.1 ( tr)4.9 (e)6.1 (a)5.9 (tme)5.9 (n)2 (t e)-4 (f)5 (f)5 (e)-4 (c)6 (t w)4 (a)6 (s)1 ( d)2 (if)-5 (f)5 (e)6 (r)5 (e)6 (n)2 (t f)-5 (r)5 (o)2 (m th)2 (a)6 (t o)2 (f )]TJ 0 -1.17 TD [(th)2 (e)6 ( o)2 (v)2 (e)6 (r)5 (a)6 (ll p)2 (a)6 (tie)6 (n)2 (t p)2 (o)2 (p)2 (u)2 (la)-4 (tio)2 (n)2 (: p)2 (a)6 (tie)6 (n)2 (ts)1 ( w)4 (ith)2 ( lo)2 (w)3.9 ( tu)11.9 (mo)2 (r)5 ( g)12.1 (r)-5.1 (a)6 (d)2 (e)6 (,)2 ( p)-8 (a)6 (tie)6 (n)2 (ts)1 ( w)4 (ith)2 (in)2 ( s)1 (p)2 (e)6 (c)6 (if)5 (ic )]TJ 0 Tc 0 Tw T* [(e)4 (t)-2 (hni)-2 (c)4 (/)-2 (r)3 (a)4 (c)4 (i)-2 (a)4 (l)-2 ( s)-1 (ub)-10 (g)10 (r)3 (oups )]TJ -0.004 Tc 0.004 Tw 9.55 0 Td [(\()-11 (B)3 (l)-6 (ack)-4 (,)-4 ( H)-2 (i)-6 (s)-5 (p)-14 (an)-4 (i)-6 (c,)-4 ( A)-2 (s)-5 (i)-6 (an)-4 (/)-6 (P)-8 (aci)-5.9 (f)-1 (i)-6 (c )-10 (I)9 (s)-5 (l)-6 (an)-4 (d)-14 (er)-1 ( p)-14 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 (\))-1 (, )-14 (an)-4 (d)-4 ( p)-4 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( > )]TJ 0 Tc 0 Tw -9.55 -1.16 Td [(65 )-10 (y)20 (e)-6 (a)4 (r)3 (s)-1 ( of )-7 (a)-6 (g)10 (e)4 (. )-10 (F)6 (or)3 ( S)-4 (t)-2 (udi)-2 (e)4 (s)-1 ( 1 a)4 (nd 2, t)-2 (he)4 ( O)2 (S)-4 ( ha)4 (z)-6 (a)4 (r)-7 (d r)3 (a)4 (t)-2 (i)-2 (o w)2 (a)4 (s)-1 ( 0.64 \()3 (95%)3 ( C)-13 (I)3 (:)-2 ( 0.55, 0.74\))3 (. A)2 (t)-2 ( 8.3 )]TJ EMC /P <>BDC /C2_0 1 Tf T* [<005C>20 <0048>-6 <0044>-6 <0055>3 <0056>-1 <000300520049>3 <00030050>-2 <0048>4 <0047004C>-12 <0044>4 <005100030049>3 <0052004F>-2 <004F>-2 <0052005A>2 <00030058>-10 <00530003003E>-7 <0024>2 <0026>-3 <013A0037>1 <002B>2 <0040>-7 <000F00030057>-2 <004B0048>4 <00030056>-1 <00580055>3 <0059004C>-2 <00590044>14 <004F>-2 <00030055>3 <0044>4 <0057>-2 <0048>4 <0003005A>2 <0044>4 <00560003>-11 <0048>4 <0056>-1 <0057>-2 <004C>-2 <0050>-2 <0044>4 <0057>-2 <0048>4 <004700030057>-2 <0052000300450048>-6 <0003001B00190011001C0008>3 <0003004C>-2 <005100030057>-2 <004B00480003>]TJ -0.002 Tc T* [<00240026>-5 <013A>-2 <0037>-1 <002B0003>-2 <0044>]TJ 0 Tc 4.41 0 Td [<0055>3 <0050>-2 <00030044>4 <005100470003001A001C001100170008>-7 <0003004C>-2 <005100030057>-2 <004B0048>4 <00030024>2 <0026>-3 <013A0037>1 <00030044>4 <0055>3 <0050>-2 <001100030037>1 <004B0048>4 <00030049>-7 <004C>-2 <00510044>4 <004F>-2 <00030032>2 <0036>-4 <00030044>4 <00510044>4 <004F>-12 <005C>20 <0056>-1 <004C>-2 <0056>-1 <00030055>-7 <0048>4 <0056>-1 <0058004F>-2 <0057>-2 <0056>-1 <00030049>3 <0055>3 <00520050>-2 <00030036>-4 <0057>-2 <00580047004C>-2 <0048>4 <0056>-1 <0003001400030044>4 <00510047000300150003>]TJ EMC /P <>BDC /TT0 1 Tf -4.41 -1.16 Td [(i)-2 (ndi)-2 (c)4 (a)4 (t)-2 (e)4 ( t)-2 (ha)4 (t)-2 ( O)2 (S)-4 ( be)4 (ne)4 (f)3 (i)-2 (t)-2 ( b)-10 (y )10 (a)-6 (ge)4 (, hor)3 (m)-2 (one )-6 (r)3 (e)4 (c)-6 (e)4 (pt)-2 (or )-7 (s)-1 (t)-2 (a)4 (t)-2 (us)-1 (, num)-2 (be)4 (r)3 ( of)3 ( pos)-1 (i)-2 (t)-2 (i)-2 (ve)4 ( l)-12 (y)20 (m)-2 (ph node)4 (s)-1 (, t)-2 (um)-2 (or )]TJ -0.004 Tc 0.004 Tw T* [(s)-5 (i)-6 (z)-10 (e an)-4 (d)-4 ( g)6 (r)-11 (ad)-4 (e,)-4 ( an)-4 (d)-4 ( s)-5 (u)-14 (r)-11 (g)6 (e)-9.9 (r)-11 (y)15.9 (/)-6 (r)-10.9 (ad)-4.1 (i)-5.9 (at)-6 (i)-6 (o)-4 (n)-4 ( t)-6 (h)-4 (er)-1 (ap)-24 (y )6 (w)-2 (as )-15 (co)-4 (n)-4 (s)-5 (i)-6 (s)-5 (t)-6 (en)-4 (t)-6 ( w)-2 (i)-6 (t)-6 (h)-4 ( t)-6 (h)-4 (e t)-6 (r)-1 (eat)-16 (m)-5.9 (en)-4 (t )-6 (ef)-1 (f)-1.1 (e)-9.9 (ct)-6 ( i)-6.1 (n)-4 ( t)-6 (h)-4 (e )]TJ EMC /P <>BDC /C2_0 1 Tf 0 Tc -0.004 Tw T* [<005200590048>4 <0055>3 <0044>4 <004F>-2 <004F>-2 <00030053005200530058004F>-2 <0044>4 <0057>-2 <004C>-2 <0052005100110003>-10 <002C>13 <0051000300530044>4 <0057>-12 <004C>-2 <0048>4 <00510057>-2 <0056>-1 <00030094>-1 <0003001800130003>-10 <005C>20 <0048>-6 <0044>4 <0055>3 <0056>-1 <000300520049>3 <00030044>-6 <004A0048>4 <0003000B>3 <0051>-10 <00030020>4 <000300150014001C001A000C>3 <000F00030057>-2 <004B0048>4 <00030032>2 <0036>-4 <0003004B0044>4 <005D>-6 <0044>4 <0055>3 <00470003>-10 <0055>-7 <0044>4 <0057>-2 <004C>-2 <00520003005A>2 <0044>4 <0056>-1 <000300130011001900180003000B>3 <001C001800080003>]TJ EMC /Lbl <>BDC /TT0 1 Tf 0 Tw 0 -1.16 TD [(C)-13 (I)23 (:)-2 ( )]TJ EMC /LBody <>BDC [(0.52, 0.81\) )-7 (a)4 (nd i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( >)4 ( 50 )-10 (y)20 (e)-6 (a)4 (r)3 (s)-1 ( o)-10 (f)3 ( a)-6 (g)10 (e )-6 (\()3 (n)-10 ( =)4 ( 1866\))3 (, t)-2 (he)4 ( O)2 (S)-4 ( ha)4 (z)-6 (a)4 (r)3 (d )-10 (r)-7 (a)4 (t)-2 (i)-2 (o w)2 (a)4 (s)-1 ( 0.63 \()3 (95% )]TJ EMC /Lbl <>BDC 0 -1.17 TD [(C)-13 (I)23 (:)-2 ( )]TJ EMC /LBody <>BDC [(0.51, 0.78\))3 (. )-10 (I)13 (n t)-2 (h)-10 (e)4 ( s)-1 (u)-10 (bg)10 (r)3 (oup o)-10 (f)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h hor)3 (m)-2 (one)4 ( r)3 (e)-6 (c)4 (e)4 (pt)-2 (or)3 (-)3 (pos)-1 (i)-2 (t)-2 (i)-2 (ve)-6 ( di)-2 (s)-1 (e)4 (a)4 (s)-1 (e)4 ( \()3 (E)1 (R)-3 (-)3 (pos)-1 (i)-2 (t)-2 (i)-2 (ve )]TJ T* [(a)4 (nd/)-2 (or)3 ( P)-4 (R)-3 (-)3 (pos)-1 (i)-2 (t)-2 (i)-2 (ve)4 (\))3 ( \()3 (n = )-6 (2223\))3 (, t)-2 (he)4 ( ha)4 (z)-6 (a)4 (r)3 (d r)-7 (a)4 (t)-2 (i)-2 (o f)3 (o)-10 (r)3 ( O)2 (S)-4 ( w)2 (a)4 (s)-1 ( 0.63 \()3 (95%)3 ( C)-13 (I)13 (: )-12 (0.51, 0.78\))3 (. )-10 (I)13 (n t)-2 (he )]TJ 0 -1.16 TD [(s)-1 (ubg)10 (r)3 (oup o)-10 (f)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h hor)3 (m)-2 (one)4 ( r)3 (e)-6 (c)4 (e)4 (pt)-2 (or)3 (-)]TJ -0.004 Tc 0.004 Tw 17.84 0 Td [(n)-14 (e)-10 (g)6 (at)-6 (i)-16 (v)-4 (e d)-4 (i)-6 (s)-5 (eas)-5 (e \()-11 (E)-3 (R)]TJ 0 Tc 0 Tw 8.4 0 Td [(-)3 (ne)-6 (g)10 (a)4 (t)-2 (i)-2 (ve )-6 (a)4 (nd P)-4 (R)-3 (-)3 (ne)4 (ga)4 (t)-2 (i)-2 (ve)4 (\))3 ( \()3 (n )]TJ -26.24 -1.17 Td [(=)4 ( 1830\))3 (, t)-2 (he)4 ( ha)4 (z)-6 (a)4 (r)3 (d )-10 (r)3 (a)4 (t)-2 (i)-2 (o )-10 (f)3 (or)3 ( O)2 (S)-4 ( w)2 (a)4 (s)-1 ( 0.64 \()3 (95)-10 (%)3 ( C)-13 (I)3 (:)-2 ( 0.52, 0.80\))3 (. )-10 (I)23 (n t)-2 (h)-10 (e)4 ( s)-1 (ub)-10 (g)10 (r)-7 (oup of)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h )]TJ EMC /P <>BDC /C2_0 1 Tf -0.004 Tw 0 -1.17 TD [<0057>-2 <00580050>-2 <00520055>3 <00030056>-1 <004C>-2 <005D>-6 <0048>4 <00030094>-1 <0003001500030046>4 <0050>-2 <0003000B>3 <005100030020>4 <00030014001900130017000C>3 <000F00030057>-2 <004B0048>4 <0003004B0044>4 <005D>-6 <0044>4 <0055>3 <004700030055>-7 <0044>4 <0057>-2 <004C>-2 <005200030049>3 <005200550003>-7 <0032>2 <0036>-4 <0003005A>2 <0044>4 <0056>-1 <000300130011001800150003000B>3 <001C00180008>3 <00030026>-13 <002C>13 <001D>-2 <000300130011>-10 <0016001C000F000300130011001A0014000C>3 <00110003>-10 <002C>13 <005100030057>-2 <004B00480003>]TJ EMC /P <>BDC /TT0 1 Tf 0 Tw 0 -1.16 TD [(s)-1 (ubg)10 (r)3 (oup o)-10 (f)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h t)-2 (um)-2 (or)3 ( s)-1 (i)-2 (z)-6 (e)4 ( >)4 ( 2 c)4 (m )-2 (\()3 (n =)4 ( 2)-10 (448\))3 (, t)-2 (he)4 ( ha)4 (z)-6 (a)4 (r)3 (d r)-7 (a)4 (t)-2 (i)-2 (o f)3 (or )-7 (O)2 (S)-4 ( w)2 (a)4 (s)-1 ( 0.67 )]TJ -0.003 Tc 0.003 Tw [(\(9)-3 (5)-3 (% )]TJ EMC /Span <>BDC 0 Tc 0 Tw 0 -1.17 TD [(C)-13 (I)23 (:)-2 ( )]TJ EMC /Span <>BDC [(0.56, 0.80\))3 (. )]TJ EMC /Artifact <>BDC 19 -3 Td (25)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 30.9288 26.9686 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4620 0 obj <>>>/Resources 4529 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4621 0 obj <> endobj 4622 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
 endstream endobj 4623 0 obj <> endobj 4624 0 obj <>stream q 1 0 0 1 21.00119 16.968689 cm 0 0 612 792 re W n 1 0 0 1 -21.00119 -16.968689 cm BT /Artifact <>BDC /CS0 cs 0 scn /TT0 1 Tf 3 Tr 12 0 0 12 93.0012 55.6087 Tm ( )Tj 20 0 Td ( )Tj 19 0 Td ( )Tj -0.004 Tc 0.004 Tw -0.24 55.83 Td ( )Tj 0 Tc 0 Tw -29.02 -1.16 Td ( )Tj -0.06 -2.34 Td ( )Tj 25.78 0 Td ( )Tj /C2_0 1 Tf -0.004 Tc -29.18 -1.17 Td <0003>Tj /TT0 1 Tf 0 Tc 5.95 0 Td ( )Tj -0.004 Tc 0.004 Tw 2.05 0 Td ( )Tj 0 Tc 0 Tw 0.26 0 Td ( )Tj /TT1 1 Tf -12.32 -2.16 Td ( )Tj /TT0 1 Tf 0.75 0 Td ( )Tj 32.24 -1.67 Td [( )-3140 ( )]TJ 0.002 Tc -0.002 Tw -26.17 -1.16 Td ( )Tj 8.58 0 Td ( )Tj 12.27 -1.17 Td ( )Tj 0 Tc 0 Tw -27.29 -1.17 Td [( )-830 ( )-2500 ( )]TJ 33.31 0 Td ( )Tj -2.37 -1.16 Td ( )Tj -23.93 -1.17 Td [( )-1510 ( )]TJ 0.002 Tc -0.002 Tw 9.75 0 Td ( )Tj 0 Tc 0 Tw 2.57 0 Td ( )Tj 0.002 Tc -0.002 Tw 10.83 0 Td ( )Tj 0 Tc 0 Tw 0.26 0 Td ( )Tj -11.03 -1.67 Td [( )-4890 ( )]TJ 14.91 -2.33 Td ( )Tj -27 -1.17 Td [( )-3580 ( )]TJ 26.46 0 Td ( )Tj -0.02 Tc 0.02 Tw 1.97 0 Td ( )Tj 0 Tc 0 Tw -32.36 -1.16 Td ( )Tj -0.004 Tc 0.004 Tw 6.86 0 Td [( )-3190 ( )]TJ 0 Tc 0 Tw 8.58 0 Td ( )Tj -0.01 Tc 0.01 Tw 13.18 0 Td ( )Tj 0 Tc 0 Tw 3.58 -1.17 Td ( )Tj -1.88 -1.17 Td ( )Tj -7.05 -1.17 Td ( )Tj -0.02 Tc 0.02 Tw -2.74 -1.66 Td ( )Tj 0 Tc 0 Tw 5.15 0 Td ( )Tj 0.002 Tc -0.002 Tw 5.05 0 Td ( )Tj 0 Tc 0 Tw -4.4 -1.17 Td [( )-4890 ( )]TJ 6.61 -1.16 Td ( )Tj -15.45 -1.17 Td [( )-3480 ( )]TJ -14.36 -1.17 Td ( )Tj 10.58 0 Td ( )Tj -0.004 Tc 0.004 Tw 6.8 0 Td ( )Tj 0 Tc 0 Tw 3.79 0 Td ( )Tj -22.2 -1.16 Td ( )Tj 13.98 0 Td ( )Tj 9.77 0 Td ( )Tj 5.86 0 Td ( )Tj -35.85 -1.17 Td ( )Tj 18.05 0 Td ( )Tj 10.22 0 Td ( )Tj -11.06 -2.33 Td ( )Tj 18.03 0 Td ( )Tj /C2_0 1 Tf -15.25 -1.17 Td <0003>Tj 14.83 0 Td <0003>Tj /TT0 1 Tf 0.002 Tc -0.002 Tw -16.7 -1.17 Td ( )Tj 0 Tc 0 Tw 10.22 0 Td ( )Tj 8.56 0 Td ( )Tj -29.59 -1.17 Td ( )Tj -0.004 Tc 0.004 Tw 18 0 Td ( )Tj 10.09 0 Td ( )Tj 0 Tc 0 Tw 0.26 0 Td ( )Tj -27.75 -1.66 Td ( )Tj 0.006 Tc -0.006 Tw 17.08 0 Td ( )Tj 0 Tc 0 Tw 5.14 0 Td ( )Tj -21.68 -1.17 Td ( )Tj 20.04 0 Td ( )Tj -0.004 Tc 0.004 Tw 6.52 0 Td ( )Tj 0 Tc 0 Tw -28.51 -1.16 Td ( )Tj -1.92 -1.17 Td [( )-3940 ( )-4890 ( )]TJ 29.66 0 Td ( )Tj -14.44 -1.17 Td ( )Tj -0.02 Tc 0.02 Tw 8.07 0 Td ( )Tj 0 Tc 0 Tw 5.15 0 Td [( )-2550 ( )]TJ -0.02 Tc 0.02 Tw -31.36 -1.16 Td ( )Tj 0 Tc 0 Tw 5.14 0 Td ( )Tj 29.63 0 Td ( )Tj -20.93 -1.17 Td ( )Tj 21.61 0 Td ( )Tj -32.55 -1.17 Td [( )-10 ( )]TJ /TT1 1 Tf -4.17 -2.17 Td ( )Tj /TT0 1 Tf 0.75 0 Td ( )Tj EMC /Span <>BDC -0.004 Tc 0.004 Tw 0 Tr -2.97 50.67 Td [(H)-2 (i)-6 (s)-5 (p)-4 (an)-4 (i)-6 (c,)-4 ( an)-4 (d)-4 ( 4)-4 (%)-1 ( A)-2 (s)-5 (i)-16 (an)-4 (/)-6 (P)-7.9 (aci)-6 (f)-0.9 (i)-6 (c )-10 (I)9 (s)-5 (l)-6 (an)-4 (d)-4 (e)-10 (r)-1 (.)-4 ( D)-2 (i)-6 (s)-5 (eas)-15 (e )-10 (ch)-4 (ar)-1 (a)-10 (ct)-6 (er)-1 (i)-6 (s)-5 (t)-6 (i)-6 (cs)-5 ( i)-6 (n)-4 (cl)-6 (u)-4 (d)-4 (ed)-3.9 ( 9)-14.1 (0)-3.9 (%)-1 ( i)-6.1 (n)-3.9 (f)-1 (i)-6 (l)-6 (t)-6 (r)-1 (at)-6 (i)-6 (n)-4 (g)6 ( d)-4 (u)-4 (ct)-16 (al )]TJ 0 Tc 0 Tw 0 -1.16 TD [(hi)-2 (s)-1 (t)-2 (ol)-2 (ogy)20 (, 38)-10 (%)3 ( T)1 (1, 91% )-7 (noda)4 (l)-2 ( i)-2 (nvol)-2 (ve)4 (m)-2 (e)4 (nt)-2 (, 27%)3 ( i)-2 (nt)-2 (e)4 (r)3 (m)-2 (e)4 (di)-2 (a)4 (t)-2 (e)4 ( a)4 (nd 66)-10 (%)3 ( hi)-2 (g)10 (h )-10 (g)10 (r)-7 (a)4 (de)4 ( pa)4 (t)-2 (hol)-2 (o)-10 (g)-10 (y)20 (, )]TJ -0.004 Tc 0.004 Tw 0 -1.17 TD [(an)-4 (d)-4 ( 5)-4 (3)-4 (%)-1 ( E)-3 (R)-7 (+ an)-4 (d)-4 (/)-6 (o)-4 (r)-1 ( P)-8 (R)-17 (+ t)-6 (u)-4 (m)-6 (o)-3.9 (r)-1 (s)-5.1 (.)-3.9 ( S)-8 (i)-6 (m)-6 (i)-6 (l)-6 (ar)-1 ( d)-4 (em)-6 (o)-4 (g)-4 (r)-1 (ap)-4 (h)-4 (i)-6 (c an)-4 (d)-4 ( b)-14 (as)-5 (el)-6 (i)-6 (n)-4 (e ch)-14 (ar)-1 (a)-10 (ct)-6 (er)-1 (i)-6 (s)-5 (t)-5.9 (i)-6 (cs)-5 ( w)-2 (er)-11 (e )]TJ 0 Tc 0 Tw T* [(r)3 (e)4 (por)3 (t)-2 (e)4 (d f)3 (o)-10 (r)3 ( t)-2 (he)4 ( e)-6 (f)3 (f)3 (i)-2 (c)-6 (a)4 (c)-16 (y )10 (e)4 (va)4 (l)-2 (ua)4 (bl)-2 (e)4 ( popul)-2 (a)4 (t)-2 (i)-2 (on, a)-6 (f)3 (t)-2 (e)4 (r)3 ( 8.3 )-20 (y)20 (e)4 (a)-6 (r)3 (s)-1 ( of)3 ( m)-2 (e)4 (di)-2 (a)4 (n )-10 (f)3 (o)-10 (l)-2 (l)-2 (ow)2 (-)3 (up i)-2 (n t)-2 (he )]TJ /C2_0 1 Tf -0.004 Tc 0.004 Tw T* [<0024>-2 <0026>-7 <013A>-4 <0053>-4 <00440046004F>-6 <004C>-6 <0057>-6 <0044005B>-14 <0048004F0003>]TJ /TT0 1 Tf 6.53 0 Td (+ )Tj 0.002 Tc -0.002 Tw [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ -0.004 Tc 0.004 Tw 5.95 0 Td [(ar)-1 (m)-6 (. )]TJ EMC /P <>BDC /TT1 1 Tf 0 Tc 0 Tw -12.48 -2.16 Td [(St)-2 (udy )4 (3 )]TJ EMC /P <>BDC /TT0 1 Tf 0 -1.67 TD [(I)13 (n S)-4 (t)-2 (ud)-20 (y)20 ( 3, br)3 (e)-6 (a)4 (s)-1 (t)-2 ( t)-2 (um)-2 (or)3 ( s)-1 (pe)4 (c)4 (i)-2 (m)-2 (e)4 (ns)-1 ( w)2 (e)-6 (r)3 (e)4 ( r)-7 (e)4 (qui)-2 (r)3 (e)4 (d )-10 (t)-2 (o s)-1 (how)2 ( H)2 (E)1 (R)-3 (2 ove)4 (r)3 (e)4 (x)-10 (pr)3 (e)-6 (s)-1 (s)-1 (i)-2 (on \()3 (3+)4 ( b)-10 (y I)13 (H)2 (C)-3 (\))3 ( or )]TJ 0.002 Tc -0.002 Tw 0 -1.16 TD [(g)12 (e)6 (n)-8 (e)6 ( a)6 (mp)2 (lif)5 (ic)6 (a)6 (tio)2 (n)2 ( \()5 (b)-18 (y )12 (F)-2 (I)5 (S)-2 (H)4 (\))5 ( a)6 (s)1 ( d)2 (e)6 (te)6 (r)5 (min)2 (e)6 (d )-8 (a)6 (t a)6 ( c)-4 (e)5.9 (n)2.1 (tr)5.1 (a)5.9 (l la)5.9 (b)2.1 (o)1.9 (r)-5 (a)6 (to)2 (r)-15 (y)22 (.)2 ( P)-2 (a)6 (tie)6 (n)2 (ts)1 ( w)4 (ith)2 ( n)2 (o)2 (d)2 (e)]TJ 0 Tc 0 Tw 34.51 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.33 0 Td [(n)-4 (e)-10 (g)6 (at)-6 (i)-6 (v)-4 (e )]TJ /C2_0 1 Tf 0 Tc 0 Tw -34.84 -1.17 Td [<0047004C>-2 <0056>-1 <0048>4 <0044>4 <0056>-1 <0048>4 <0003005A>2 <0048>-6 <0055>3 <0048>4 <00030055>-7 <0048>4 <00540058004C>-2 <0055>3 <0048>4 <004700030057>-2 <00520003>-10 <004B0044>4 <00590048>4 <00030095>-1 <00030037>1 <00140046>4 <000300530055>3 <004C>-2 <0050>]TJ /TT0 1 Tf 0.002 Tc -0.002 Tw 16.56 0 Td [(a)-4 (r)-15 (y)22 ( tu)2 (mo)2 (r)5 (.)2 ( P)-2 (a)6 (tie)6 (n)2 (ts)1 ( w)4 (ith)2 ( a)6 ( h)2 (is)1 (to)2 (r)-5 (y )12 (o)2 (f)5 ( c)6 (o)2 (n)-8 (g)12 (e)6 (s)1 (tiv)2 (e)5.9 ( h)2 (e)-3.9 (a)6 (r)5 (t )]TJ -0.003 Tc 0.003 Tw -16.56 -1.17 Td [(fa)1 (i)-5 (l)-5 (u)-3 (re )]TJ 0 Tc 0 Tw 2.85 0 Td [(or )-7 (L)11 (V)-8 (E)1 (F )-4 (<)4 ( 55%)3 (, )-10 (unc)4 (ont)-2 (r)3 (ol)-2 (l)-2 (e)4 (d a)4 (r)3 (r)3 (h)-20 (y)20 (t)-2 (hm)-2 (i)-2 (a)4 (s)-11 (, a)4 (ng)10 (i)-2 (n)-10 (a)4 ( r)3 (e)4 (qui)-2 (r)3 (i)-2 (n)-10 (g)10 ( m)-2 (e)4 (di)-12 (c)4 (a)-6 (t)-2 (i)-2 (on, c)4 (l)-2 (i)-2 (ni)-2 (c)4 (a)4 (l)-2 (l)-12 (y )]TJ -2.85 -1.16 Td [(s)-1 (i)-2 (g)10 (ni)-2 (f)3 (i)-2 (c)4 (a)4 (nt)-2 ( v)-10 (a)4 (l)-2 (vul)-2 (a)4 (r)3 ( he)-6 (a)4 (r)3 (t)-12 ( di)-2 (s)-1 (e)4 (a)4 (s)-1 (e)4 (, e)4 (vi)-2 (de)4 (n)-10 (c)4 (e)4 ( of)3 ( t)-12 (r)3 (a)4 (n)-10 (s)-1 (m)-2 (ur)3 (a)4 (l)-2 ( i)-2 (nf)3 (a)4 (r)3 (c)4 (t)-2 (i)-2 (on on E)1 (C)-13 (G)2 (, poor)3 (l)-12 (y )10 (c)4 (ont)-2 (r)3 (ol)-2 (l)-2 (e)4 (d )]TJ 0 -1.17 TD [(h)-10 (y)20 (pe)-6 (r)3 (t)-2 (e)4 (ns)-1 (i)-2 (on \()3 (s)-21 (y)20 (s)-1 (t)-2 (ol)-2 (i)-2 (c)4 ( > )-6 (180 )]TJ 0.002 Tc -0.002 Tw [(mm H)4 (g)12 ( o)2 (r)5 ( d)2 (ia)6 (s)1 (to)2 (lic )-4 (>)6 ( 1)2 (0)2 (0 )2 (mm H)4 (g)2 (\))5 ( w)4 (e)6 (r)-5 (e)6 ( n)2 (o)2 (t )-10 (e)6 (lig)12 (ib)2 (le)6 (. )]TJ EMC /P <>BDC 0 Tc 0 Tw 0 -1.67 TD [(S)-4 (t)-2 (ud)-10 (y)30 ( 3 )-10 (w)2 (a)4 (s)-1 ( de)4 (s)-1 (i)-12 (g)10 (ne)4 (d t)-2 (o )-10 (c)4 (om)-2 (pa)4 (r)3 (e)4 ( on)-10 (e)4 ( a)4 (nd t)-2 (w)2 (o )-20 (y)20 (e)-6 (a)-6 (r)3 (s)-1 ( of )]TJ 0.002 Tc -0.002 Tw 22.24 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)-6 (nt)-2 ( ve)4 (r)3 (s)-1 (us)-1 ( obs)-1 (e)4 (r)3 (va)4 (t)-2 (i)-2 (on )]TJ -27.38 -1.16 Td [(i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h H)2 (E)1 (R)-3 (2 pos)-1 (i)-2 (t)-2 (i)-2 (ve)4 ( E)1 (B)7 (C)-3 ( f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng)10 ( s)-1 (ur)-7 (g)10 (e)-6 (r)-17 (y)20 (, e)4 (s)-1 (t)-2 (a)4 (bl)-2 (i)-2 (s)-1 (he)4 (d c)4 (h)-10 (e)4 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( a)4 (nd )]TJ -0.004 Tc 0.014 Tw 0 -1.17 TD [(r)-1 (ad)-4 (i)-6 (o)-4 (t)-6 (h)-4 (er)-1 (ap)-24 (y)16 ( \()]TJ 0 Tc 0 Tw 5.63 0 Td [(i)-2 (f)3 ( a)4 (ppl)-2 (i)-2 (c)-6 (a)4 (bl)-2 (e)4 (\))3 (. P)-4 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (e)4 (r)-7 (e)4 ( r)3 (a)4 (ndom)-2 (i)-12 (z)-6 (e)4 (d \()3 (1:)-2 (1:)-2 (1\))3 ( upon c)4 (om)-2 (pl)-2 (e)4 (t)-2 (i)-2 (on of)3 ( de)4 (f)3 (i)-2 (ni)-2 (t)-2 (i)-2 (ve )]TJ -5.63 -1.17 Td [(s)-1 (ur)3 (ge)4 (r)-17 (y)20 (, a)4 (nd )-10 (a)4 (t)-2 ( l)-2 (e)4 (a)4 (s)-1 (t)-2 ( f)3 (our )-7 (c)-6 (y)20 (c)-6 (l)-2 (e)4 (s)-1 ( of )-7 (c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)-7 (a)4 (p)-20 (y)20 ( t)-2 (o r)3 (e)4 (c)4 (e)4 (i)-2 (v)-10 (e)4 ( no a)4 (ddi)-2 (t)-2 (i)-2 (ona)4 (l)-2 ( t)-2 (r)-7 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 (, or)3 ( one )]TJ -0.02 Tc 0.02 Tw 36.63 0 Td [(ye)-26 (a)-16 (r )]TJ -0.003 Tc 0.003 Tw -36.63 -1.16 Td [(o)-3 (f )]TJ 0.002 Tc -0.002 Tw [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ -0.004 Tc 0.004 Tw 6.22 0 Td [(t)-6 (r)-1 (eat)-6 (m)-6 (en)-4 (t)-16 ( o)-4 (r)-1 ( t)-6 (w)-2 (o )-14 (y)16 (e)-10 (ar)-1 (s)-5 ( o)-14 (f )]TJ 0.002 Tc -0.002 Tw 10.3 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )2 (tr)5 (e)6 (a)6 (tme)6 (n)2 (t.)2 ( P)-2 (a)6 (tie)6 (n)2 (ts)1 ( u)2 (n)2 (d)2 (e)6 (r)-5 (g)]TJ -0.01 Tc 0.01 Tw 15.6 0 Td [(o)-10 (i)-12 (n)-20 (g a )]TJ 0 Tc 0 Tw -32.12 -1.17 Td [(l)-2 (um)-2 (pe)4 (c)4 (t)-2 (om)-12 (y)20 ( ha)4 (d )-10 (a)4 (l)-2 (s)-1 (o c)4 (o)-10 (m)-2 (pl)-2 (e)4 (t)-2 (e)4 (d s)-1 (t)-2 (a)4 (nda)4 (r)3 (d r)-7 (a)4 (di)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 (. P)-4 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h E)1 (R)-3 (+)-6 ( a)4 (nd/)-2 (or)3 ( P)-4 (g)10 (R)-3 (+)4 ( di)-2 (s)-1 (e)-6 (a)4 (s)-1 (e )]TJ T* [(r)3 (e)4 (c)4 (e)4 (i)-2 (v)-10 (e)4 (d s)-21 (y)30 (s)-1 (t)-12 (e)4 (m)-2 (i)-2 (c)4 ( a)4 (dj)-2 (uva)-6 (nt)-2 ( hor)3 (m)-2 (ona)4 (l)-2 ( t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( a)4 (t)-2 ( i)-2 (n)-10 (ve)4 (s)-1 (t)-2 (i)-2 (g)10 (a)4 (t)-2 (or)3 ( di)-2 (s)-1 (c)-6 (r)3 (e)4 (t)-2 (i)-2 (on. T)1 (he)-6 ( m)-2 (a)4 (i)-2 (n out)-2 (c)4 (om)-2 (e )]TJ -0.004 Tc 0.004 Tw T* [(m)-6 (eas)-5 (u)-4 (r)-1 (e w)-12 (as)-5 ( D)-2 (i)-6 (s)-5 (eas)-15 (e)]TJ 0 Tc 0 Tw [(-)-7 (F)6 (r)3 (e)-6 (e)4 ( S)-4 (ur)3 (vi)-2 (va)4 (l)-2 ( \()3 (D)2 (F)6 (S)-4 (\))3 (, d)-10 (e)4 (f)3 (i)-2 (ne)-6 (d a)4 (s)-1 ( i)-2 (n S)-4 (t)-2 (udi)-2 (e)4 (s)-1 ( 1 a)4 (nd 2. )]TJ EMC /P <>BDC 0.002 Tc -0.002 Tw 0 -1.66 TD [(A)4 ( p)2 (r)5 (o)2 (to)2 (c)6 (o)2 (l s)1 (p)2 (e)6 (c)6 (if)5 (ie)6 (d)2 ( in)2 (te)-4 (r)5 (im e)6 (f)5 (f)5 (ic)6 (a)-4 (c)-14.1 (y)22.1 ( a)6 (n)-8 (a)6 (l)-10 (y)22 (s)1 (is)0.9 ( c)6 (o)-8 (mp)2.1 (a)6 (r)5 (in)2 (g)12 ( o)2 (n)-8 (e)]TJ 0 Tc 0 Tw 24.45 0 Td (-)Tj -0.02 Tc 0.02 Tw 0.35 0 Td [(ye)-26 (a)-16 (r )]TJ 0.002 Tc -0.002 Tw 1.95 0 Td [(tr)-5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )2 (tr)5 (e)6 (a)6 (tme)6 (n)2 (t to )]TJ 0 Tc 0 Tw -26.75 -1.17 Td [(obs)-1 (e)4 (r)3 (va)4 (t)-2 (i)-2 (on w)2 (a)4 (s)-1 ( p)-10 (e)4 (r)3 (f)3 (or)3 (m)-12 (e)4 (d a)4 (t)-2 ( a)4 ( m)-2 (e)4 (di)-2 (a)4 (n )-10 (f)3 (ol)-2 (l)-2 (ow)2 (-)3 (up)-10 ( dur)3 (a)4 (t)-2 (i)-2 (on of)3 ( 12.6 m)-2 (ont)-2 (hs)-1 ( i)-2 (n t)-2 (he )]TJ 0.002 Tc -0.002 Tw 32.55 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw -32.55 -1.16 Td [(a)4 (r)3 (m)-2 ( a)4 (nd f)3 (or)3 (m)-12 (e)4 (d t)-2 (he)4 ( ba)4 (s)-1 (i)-2 (s)-11 ( f)3 (or)3 ( t)-2 (he)4 ( de)4 (f)3 (i)-2 (ni)-2 (t)-2 (i)-2 (ve)4 ( D)-8 (F)6 (S)-4 ( r)3 (e)-6 (s)-1 (ul)-2 (t)-2 (s)-1 ( f)3 (r)3 (om)-2 ( t)-2 (hi)-2 (s)-1 ( s)-1 (t)-2 (ud)-10 (y)30 (. A)2 (m)-12 (ong)10 ( t)-2 (he)4 ( 3386 p)-10 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s )]TJ 0 -1.17 TD [(r)3 (a)4 (ndom)-2 (i)-2 (z)-6 (e)4 (d t)-2 (o t)-2 (he)4 ( obs)-1 (e)4 (r)3 (v)-10 (a)4 (t)-2 (i)-2 (on \()3 (n =)4 ( 1693\))3 ( a)4 (nd )]TJ -0.004 Tc 0.004 Tw [(t)-6 (r)-11 (as)-5 (t)-16 (u)-4 (z)-10 (u)-4 (m)-6 (ab )]TJ 0 Tc 0 Tw 23.71 0 Td [(one)4 (-)-7 (y)20 (e)-6 (a)4 (r )-7 (\()3 (n =)4 ( 16)-10 (93\))3 ( t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( a)-6 (r)3 (m)-2 (s)-1 (, )]TJ -0.004 Tc 0.004 Tw -23.71 -1.17 Td [(t)-6 (h)-4 (e m)-6 (ed)-4 (i)-6 (an)-4 ( a)-10 (g)6 (e )-10 (w)-2 (as)-5 ( 4)-4 (9 )-24 (y)6 (ear)-1 (s)-5 ( \()-11 (r)-1 (an)-14 (g)6 (e 2)-4 (1)]TJ 0 Tc 0 Tw 15.51 0 Td [(\22680)-10 (\))3 (, 83% )]TJ -0.004 Tc 0.004 Tw 4.43 0 Td [(w)-2 (er)-1 (e C)-7 (au)-14 (cas)-5 (i)-6 (an)-4 (, )-14 (an)-4 (d)-4 ( 1)-4 (3)-14 (% )-1 (w)-2 (er)-11 (e A)-2 (s)-5 (i)-6 (an)-4 (.)-4 ( D)-2 (i)-6 (s)-5 (e)-10 (as)-4.9 (e )]TJ -19.94 -1.16 Td [(ch)-4 (ar)-1 (a)-10 (ct)-6 (er)-1 (i)-6 (s)-5 (t)-6 (i)-6 (cs)-5 (:)-6 ( 9)-4 (4)-4 (% )-1 (i)-6 (n)-3.9 (f)-1.1 (i)-6 (l)-16 (t)-6 (r)-1 (at)-6 (i)-6 (n)-3.9 (g)5.9 ( d)-4 (u)-4 (ct)-16 (al)-6 ( car)-10.9 (ci)]TJ 0 Tc 0.01 Tw 17.49 0 Td [(nom)-2 (a)4 (, 50% )]TJ 0 Tw 4.81 0 Td [(E)1 (R)-3 (+)4 ( a)4 (nd/)-2 (or)3 ( P)-14 (g)10 (R)-3 (+)4 (, )-10 (57% )3 (node)4 ( pos)-1 (i)-2 (t)-2 (i)-2 (ve)4 (, )]TJ -22.3 -1.17 Td [(32% )3 (node)4 ( ne)-6 (ga)4 (t)-2 (i)-2 (ve)4 (, a)4 (nd i)-12 (n 11%)3 ( of)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 (, noda)4 (l )-12 (s)-1 (t)-2 (a)4 (t)-2 (us)-1 ( w)2 (a)4 (s)-1 ( not)-2 ( a)4 (s)-1 (s)-1 (e)4 (s)-1 (s)-1 (a)4 (bl)-2 (e )-6 (due)4 ( t)-2 (o pr)3 (i)-2 (or)3 ( ne)4 (o\255)]TJ T* [(a)4 (dj)-2 (uva)4 (nt)-2 ( c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)-7 (a)4 (p)-20 (y)20 (. )-10 (N)2 (i)-2 (ne)4 (t)-12 (y)20 (-)3 (s)-1 (i)-2 (x)-10 ( pe)4 (r)3 (c)-6 (e)4 (nt)-2 ( \()3 (1055)-10 (/)-2 (1098\))3 ( of)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h node)4 (-)]TJ -0.004 Tc 0.004 Tw 31.46 0 Td [(n)-4 (e)-10 (g)6 (at)-6 (i)-6 (v)-4 (e d)-4 (i)-6 (s)-15 (eas)-5 (e )]TJ 0 Tc 0 Tw -31.46 -1.16 Td [(ha)4 (d hi)-2 (g)10 (h-)]TJ -0.003 Tc 0.003 Tw 3.8 0 Td [(ri)-5 (s)-4 (k)-3 ( fe)-9 (a)1 (t)-5.1 (u)-2.9 (re)1 (s)-4 (:)-5 ( a)]TJ 0 Tc 0 Tw 5.89 0 Td [(m)-2 (ong)10 ( t)-2 (he)4 ( 1098 pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s )-11 (w)2 (i)-2 (t)-2 (h node)4 (-)3 (ne)-6 (g)10 (a)4 (t)-2 (i)-2 (ve)4 ( di)-2 (s)-1 (e)-6 (a)-6 (s)-1 (e)4 (, 49%)3 ( \()3 (543\))3 ( w)-8 (e)4 (r)-7 (e )]TJ EMC /P <>BDC /C2_0 1 Tf -9.69 -1.17 Td [<0028>1 <0035>-3 <00ED>4 <00030044>4 <0051004700030033>-4 <004A>10 <0035>-3 <00ED>4 <000F0003>-10 <0044>4 <0051004700030017001A0008>-7 <0003000B>3 <001800140015000C>3 <0003005A>2 <0048>-6 <0055>3 <0048>4 <00030028>1 <0035>-3 <00030044>4 <005100470012>-2 <00520055>3 <00030033>-14 <004A>10 <0035>-3 <0003000E0003>-6 <0044>4 <005100470003004B0044>4 <004700030044>4 <0057>-2 <0003004F>-2 <0048>-6 <0044>4 <0056>-1 <0057>-2 <0003005200510048>-6 <000300520049>3 <00030057>-2 <004B0048>4 <00030049>3 <0052004F>-2 <004F>-2 <0052005A>2 <004C>-2 <0051004A0003>]TJ EMC /P <>BDC /TT0 1 Tf -0.01 Tc 0.01 Tw T* [(h)-10 (i)-12 (gh)]TJ 0 Tc 0 Tw 1.77 0 Td (-)Tj 0.002 Tc -0.002 Tw 0.33 0 Td [(r)5 (is)1 (k)2 ( f)-5 (e)6 (a)6 (tu)2 (r)-5 (e)6 (s)1 (: p)2 (a)6 (th)2 (o)2 (lo)2 (g)12 (ic)-4 (a)6 (l tu)2 (mo)2 (r)5 ( s)1 (iz)-4 (e)6 ( g)12 (r)5 (e)-4 (a)6 (te)6 (r )-5 (th)2.1 (a)6 (n)2 ( 2)2 ( c)6 (m,)2.1 ( G)4 (r)5 (a)6 (d)-8 (e)6 ( 2)]TJ 0 Tc 0 Tw 25.74 0 Td [(\2263, or )-7 (a)4 (ge)4 ( <)4 ( 35 )-20 (y)20 (e)-6 (a)4 (r)3 (s)-1 (. P)-4 (r)3 (i)-2 (or )]TJ -27.84 -1.17 Td [(t)-2 (o r)3 (a)4 (ndom)-2 (i)-2 (z)-6 (a)4 (t)-2 (i)-2 (on, 94% )3 (of)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( ha)4 (d r)3 (e)-6 (c)4 (e)4 (i)-2 (ve)4 (d )-10 (a)4 (nt)-2 (hr)3 (a)4 (c)-16 (y)20 (c)4 (l)-2 (i)-2 (ne)-6 (-)]TJ -0.004 Tc 0.004 Tw 24.87 0 Td [(b)-4 (as)-5 (ed )-14 (ch)-4 (em)-6 (o)-4 (t)-16 (h)-4 (er)-1 (ap)-24 (y)16 ( r)-11 (e)-10 (g)6 (i)-6 (m)-5.9 (en)-4.1 (s)-4.9 (. )]TJ EMC /P <>BDC 0 Tc 0 Tw -24.87 -1.66 Td [(A)2 (f)3 (t)-2 (e)4 (r)3 ( t)-2 (he)4 ( d)-10 (e)4 (f)3 (i)-2 (ni)-2 (t)-2 (i)-2 (ve)4 ( D)2 (F)6 (S )-14 (r)3 (e)4 (s)-1 (ul)-2 (t)-2 (s)-1 ( c)4 (om)-2 (pa)4 (r)3 (i)-2 (n)-10 (g)10 ( obs)-1 (e)4 (r)3 (v)-10 (a)4 (t)-2 (i)-2 (on t)-2 (o one)4 (-)]TJ 0.006 Tc -0.006 Tw 25.11 0 Td [(y)26 (ear )]TJ 0.002 Tc -0.002 Tw 1.96 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ -0.004 Tc 0.004 Tw 5.14 0 Td [(t)-6 (r)-1 (eat)-6 (m)-6 (en)-4 (t)-6 ( w)-2 (e)-10 (r)-1 (e )]TJ 0 Tc 0 Tw -32.21 -1.17 Td [(di)-2 (s)-1 (c)4 (l)-2 (os)-1 (e)4 (d, a)4 ( pr)3 (os)-1 (pe)-6 (c)4 (t)-2 (i)-2 (ve)4 (l)-2 (y )10 (pl)-2 (a)4 (nn)-10 (e)4 (d a)4 (na)4 (l)-22 (y)20 (s)-1 (i)-2 (s)-1 ( t)-2 (ha)4 (t)-2 ( i)-2 (n)-10 (c)4 (l)-2 (ude)4 (d c)4 (om)-2 (pa)4 (r)3 (i)-2 (s)-1 (on of)3 ( on)-10 (e )]TJ -0.004 Tc 0.004 Tw 30.58 0 Td [(y)16 (e)-10 (ar)-1 ( v)-14 (er)-1 (s)-5 (u)-4 (s)-5 ( t)-6 (w)-2 (o )]TJ -0.003 Tc 0.003 Tw -30.58 -1.16 Td [(y)17 (e)-9 (a)-9 (rs)-4 ( o)-3 (f )]TJ 0.002 Tc -0.002 Tw [(tr)-5 (a)5.9 (s)1.1 (tu)1.9 (z)-4 (u)2 (ma)6.1 (b )2 (tr)4.9 (e)6 (a)-4 (tme)6.1 (n)1.9 (t a)6.1 (t a)5.9 ( me)6 (d)2.1 (ia)5.9 (n)2 ( f)5.1 (o)1.9 (llo)2.1 (w)]TJ 0 Tc 0 Tw 20.08 0 Td [(-)3 (up dur)3 (a)4 (t)-2 (i)-2 (on of)3 ( 8 )-20 (y)20 (e)-6 (a)4 (r)3 (s)-1 ( w)-8 (a)4 (s)-1 ( pe)4 (r)3 (f)3 (o)-10 (r)3 (m)-2 (e)4 (d. )-10 (B)7 (a)4 (s)-1 (e)4 (d )]TJ -20.08 -1.17 Td [(on t)-2 (hi)-2 (s)-1 ( a)4 (na)4 (l)-12 (y)20 (s)-1 (i)-2 (s)-1 (, e)4 (x)-10 (t)-2 (e)4 (ndi)-2 (ng )]TJ 0.002 Tc -0.002 Tw 10.85 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(t)-2 (r)3 (e)-6 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( f)3 (or)3 ( a)4 ( dur)-7 (a)4 (t)-2 (i)-2 (on of)3 ( t)-2 (w)2 (o )-20 (y)20 (e)4 (a)-6 (r)3 (s)-1 ( di)-2 (d not)-2 ( s)-1 (how )]TJ -0.004 Tc 0.004 Tw -15.99 -1.17 Td [(ad)-4 (d)-4 (i)-6 (t)-6 (i)-6 (o)-4 (n)-4 (al)-6 ( b)-4 (en)-4 (ef)-1 (i)-6 (t)-6 ( o)-4 (v)-4 (er)-0.9 ( t)-6.1 (r)-10.9 (eat)-6 (m)-6 (en)-4 (t)-6 ( f)-1 (o)-4 (r)-1 ( o)-4 (n)-14 (e )-20 (y)16 (ea)-10 (r)-1 ( [)-11 (H)-2 (a)-10 (z)-10 (ar)-1 (d )]TJ 0.002 Tc -0.002 Tw 21.88 0 Td [(R)-1 (a)6 (tio)2 (s)1 ( o)2 (f)5 ( tw)4 (o)]TJ 0 Tc 0 Tw 5.39 0 Td (-)Tj -0.02 Tc 0.02 Tw 0.34 0 Td [(ye)-26 (a)-16 (r)-17 (s )]TJ 0.002 Tc -0.002 Tw 2.35 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(ve)4 (r)3 (s)-1 (us )]TJ -35.1 -1.16 Td [(one)4 (-)]TJ -0.02 Tc 0.02 Tw 1.79 0 Td [(ye)-16 (a)-26 (r )]TJ 0.002 Tc -0.002 Tw 1.95 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )2 (tr)5 (e)-4 (a)6 (tme)6 (n)2 (t in)2 ( th)2 (e)6 ( in)2 (te)6 (n)2 (t to)2 ( tr)5 (e)6 (a)6 (t \()-5 (I)15 (T)3 (T)3 (\))5 ( p)2 (o)2 (p)2 (u)2 (la)6 (tio)1.9 (n)2 ( f)5.1 (o)-8.1 (r)5.1 ( D)-6 (is)1 (e)6.1 (a)5.9 (s)1 (e)]TJ 0 Tc 0 Tw 28.77 0 Td [(-)-7 (F)6 (r)3 (e)-6 (e)4 ( S)-4 (ur)3 (vi)-2 (va)4 (l )]TJ -32.51 -1.17 Td [(\()3 (D)2 (F)6 (S)-4 (\))3 ( =)4 ( 0.99 )-10 (\()3 (95%)3 ( C)-13 (I)13 (:)-2 ( 0)-10 (.87, 1.13\))3 (, p-)3 (va)4 (l)-2 (ue )-6 (=)4 ( 0.90)-10 ( a)4 (nd O)2 (ve)4 (r)-7 (a)4 (l)-2 (l)-2 ( S)-4 (ur)3 (vi)-2 (va)4 (l)-2 ( \()3 (O)-8 (S)-4 (\))3 ( =)4 ( 0.98 \()3 (0.83, 1.15\))3 (; )]TJ T* [(p-)3 (va)4 (l)-2 (ue)4 ( =)4 ( 0.78])-7 (. )]TJ EMC /P <>BDC /TT1 1 Tf 0 -2.17 TD [(St)-2 (udy )4 (4 )]TJ EMC /Artifact <>BDC /TT0 1 Tf 19 -5.16 Td (24)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 31.0012 26.9687 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4625 0 obj <>>>/Resources 4528 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4626 0 obj <> endobj 4627 0 obj <>stream /
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0.72 re f 190.68 685.32 0.72 0.72 re f 191.4 685.32 32.04 0.72 re f 223.44 685.32 0.72 0.72 re f 224.16 685.32 50.04 0.72 re f 274.2 685.32 0.72 0.72 re f 274.92 685.32 49.919 0.72 re f 324.84 685.32 0.72 0.72 re f 325.56 685.32 68.64 0.72 re f 394.2 685.32 0.72 0.72 re f 394.92 685.32 53.04 0.72 re f 447.96 685.32 0.72 0.72 re f 448.68 685.32 64.561 0.72 re f 513.24 685.32 0.72 0.72 re f 513.24 685.32 0.72 0.72 re f 72 615.96 0.72 69.36 re f 125.04 615.96 0.72 69.36 re f 190.68 615.96 0.72 69.36 re f 223.44 615.96 0.72 69.36 re f 274.2 615.96 0.72 69.36 re f 324.84 615.96 0.72 69.36 re f 394.2 615.96 0.72 69.36 re f 447.96 615.96 0.72 69.36 re f 513.24 615.96 0.72 69.36 re f q 1 0 0 1 -20.688599 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 126.2776 580.8458 Tm ( )Tj 0.002 Tc -0.002 Tw 6.044 2.304 Td ( )Tj 0 Tc 0 Tw 0.021 -1.163 Td ( )Tj 4.152 0.576 Td ( )Tj 3.652 1.152 Td ( )Tj 0.043 -2.293 Td ( )Tj 4.435 2.293 Td ( )Tj 0.163 -2.293 Td ( )Tj 5.522 2.293 Td ( )Tj 0.435 -1.141 Td ( )Tj -0.272 -1.152 Td ( )Tj 4.913 1.141 Td ( )Tj 6.522 0.587 Td ( )Tj -0.522 -1.163 Td ( )Tj ET Q 72 615.24 0.72 0.72 re f 72.72 615.24 52.32 0.72 re f 125.04 615.24 0.72 0.72 re f 125.76 615.24 64.921 0.72 re f 190.68 615.24 0.72 0.72 re f 191.4 615.24 32.04 0.72 re f 223.44 615.24 0.72 0.72 re f 224.16 615.24 50.04 0.72 re f 274.2 615.24 0.72 0.72 re f 274.92 615.24 49.919 0.72 re f 324.84 615.24 0.72 0.72 re f 325.56 615.24 68.64 0.72 re f 394.2 615.24 0.72 0.72 re f 394.92 615.24 53.04 0.72 re f 447.96 615.24 0.72 0.72 re f 448.68 615.24 64.561 0.72 re f 513.24 615.24 0.72 0.72 re f 72 558.6 0.72 56.64 re f 72 557.88 0.72 0.72 re f 72 557.88 0.72 0.72 re f 72.72 557.88 52.32 0.72 re f 125.04 558.6 0.72 56.64 re f 125.04 557.88 0.72 0.72 re f 125.76 557.88 64.921 0.72 re f 190.68 558.6 0.72 56.64 re f 190.68 557.88 0.72 0.72 re f 191.4 557.88 32.04 0.72 re f 223.44 558.6 0.72 56.64 re f 223.44 557.88 0.72 0.72 re f 224.16 557.88 50.04 0.72 re f 274.2 558.6 0.72 56.64 re f 274.2 557.88 0.72 0.72 re f 274.92 557.88 49.919 0.72 re f 324.84 558.6 0.72 56.64 re f 324.84 557.88 0.72 0.72 re f 325.56 557.88 68.64 0.72 re f 394.2 558.6 0.72 56.64 re f 394.2 557.88 0.72 0.72 re f 394.92 557.88 53.04 0.72 re f 447.96 558.6 0.72 56.64 re f 447.96 557.88 0.72 0.72 re f 448.68 557.88 64.561 0.72 re f 513.24 558.6 0.72 56.64 re f 513.24 557.88 0.72 0.72 re f 513.24 557.88 0.72 0.72 re f q 1 0 0 1 -20.688599 -16.838623 cm BT /TT0 1 Tf 3 Tr 9.96 0 0 9.96 95.5686 565.3586 Tm ( )Tj 0.002 Tc 0.001 Tw 22.7 0 Td ( )Tj 0 Tc 0 Tw ( )Tj -22.664 -1.145 Td ( )Tj -0.001 Tc 0.004 Tw 9.409 0 Td ( )Tj 0 Tc 0 Tw 14.687 0 Td ( )Tj /TT2 1 Tf 12 0 0 12 191.6886 528.3986 Tm ( )Tj /TT0 1 Tf -0.004 Tc 0.004 Tw 25.68 -1.67 Td ( )Tj /C2_0 1 Tf 0 Tc 0 Tw -8.9 -1.16 Td <0003>Tj /TT0 1 Tf -23.38 -1.17 Td ( )Tj -0.004 Tc 0.004 Tw 17.1 0 Td ( )Tj 0 Tc 0 Tw -0.18 -1.17 Td ( )Tj 15.84 0 Td ( )Tj -2.86 -2.33 Td ( )Tj /TT2 1 Tf -21.61 -1.67 Td ( )Tj /TT0 1 Tf 0.002 Tc -0.002 Tw 27.69 -2.83 Td ( )Tj 0 Tc 0 Tw -19.41 -1.17 Td ( )Tj /TT2 1 Tf -7 -1.66 Td ( )Tj /TT0 1 Tf 24.66 0 Td ( )Tj -8.8 -1.17 Td ( )Tj 8.61 0 Td [( )-1950 ( )]TJ 0.002 Tc -0.002 Tw -4.91 -1.17 Td ( )Tj 6.73 0 Td ( )Tj 0 Tc 0 Tw -5.11 -1.17 Td ( )Tj -21.35 -1.66 Td ( )Tj 27.38 0 Td ( )Tj -18.94 -1.17 Td ( )Tj 17.14 0 Td ( )Tj -19.16 -1.17 Td ( )Tj /TT1 1 Tf 14.04 0 0 14.04 106.7286 220.7186 Tm ( )Tj 17.282 0 Td ( )Tj -16.538 -2.009 Td ( )Tj 24.812 0 Td ( )Tj /TT0 1 Tf 12 0 0 12 199.6086 172.1186 Tm ( )Tj 19.17 0 Td ( )Tj -14.32 -1.66 Td ( )Tj 24.31 -1.17 Td ( )Tj -32.71 -1.16 Td ( )Tj 9.1 0 Td ( )Tj 14.44 0 Td ( )Tj -26.29 -1.17 Td ( )Tj 27.24 0 Td [( )-4870 ( )]TJ -0.01 Tc 0.01 Tw 9 0 Td ( )Tj 0 Tc 0 Tw -33.71 -1.17 Td ( )Tj ET Q EMC 1 0 0 1 -20.688599 -16.838623 cm BT /Span <>BDC /TT1 1 Tf 12 0 0 12 92.6886 725.4386 Tm [(T)-3 (ab)-4 (l)-2 (e )4 (6: )]TJ 0.004 Tc -0.004 Tw 6 0 Td [(P)15 (o)4 (pul)2 (a)4 (t)7 (i)2 (o)4 (n P)15 (r)-2 (e)8 (di)2 (c)8 (t)7 (e)8 (d St)-3 (e)8 (a)4 (dy)3.9 ( St)7 (a)4 (t)7 (e )-2 (P)5 (K )12 (E)1 (x)4 (po)4 (s)3 (ur)8 (e)8 (s)3 ( \()7 (M)8 (e)8 (di)2 (a)4 (n w)-4 (i)2 (t)7 (h 5)]TJ EMC /StyleSpan <>BDC -0.005 Tc 0 Tw 8.04 0 0 8.04 496.8486 729.3986 Tm (th )Tj EMC /Span <>BDC 0 Tc 12 0 0 12 506.9286 725.4386 Tm (\226 95)Tj EMC /StyleSpan <>BDC -0.005 Tc 8.04 0 0 8.04 527.9286 729.3986 Tm (th )Tj EMC /Span <>BDC -0.004 Tc 0.004 Tw 12 0 0 12 164.6886 711.3986 Tm [(P)7 (e)-10 (rc)-10 (en)-8 (t)-1 (i)-6 (l)-6 (es)-5 (\))-1 ( i)-6 (n)-8 ( B)-7 (rea)-4 (s)-5 (t)-1 ( C)-12 (a)-3.9 (n)-8.1 (cer )-10 (P)7 (a)-4 (t)-1 (i)-6 (en)-8 (t)-1 (s )]TJ EMC /TH <>BDC -0.002 Tc 0 Tw 11.04 0 0 11.04 98.4486 663.5186 Tm [(Sc)-3.7 (he)-3.7 (dul)4.3 (e )]TJ EMC /TH <>BDC 0 Tc 5.478 0.576 Td [(P)-8.6 (r)9.3 (i)-4.7 (m)7 (ar)-1.7 (y )]TJ 0.004 Tc -0.004 Tw -0.554 -1.152 Td [(tu)5.7 (mo)14.9 (r)2.3 ( ty)4 (p)16.5 (e )]TJ EMC /TH <>BDC 0 Tc 0 Tw 6.456 0.576 Td (N )Tj EMC /TH <>BDC 2.76 0.576 Td (C)Tj -0.022 Tc 6.96 0 0 6.96 262.4886 668.9186 Tm [(m)-16.6 (i)-37.1 (n,)-30.6 (s)-29.6 (s)]TJ 0 Tc 2.707 0.707 Td (a )Tj 11.04 0 0 11.04 250.3734 657.1605 Tm [(\()-4 (\265g/)6.2 (m)-3.9 (L)3.9 (\) )]TJ EMC /TH <>BDC 4.913 1.152 Td (C)Tj -0.017 Tc 6.96 0 0 6.96 312.5286 668.9186 Tm [(m)-11.6 (a)-34.2 (x,)-25.6 (s)-24.6 (s )]TJ 0 Tc 2.879 0.707 Td (b )Tj 11.04 0 0 11.04 301.1286 657.1586 Tm [(\()-4 (\265g/)6.2 (m)-3.9 (L)3.9 (\) )]TJ EMC /TH <>BDC -0.005 Tc 5.131 1.728 Td (AUC)Tj 0.007 Tc 0.002 Tw 6.96 0 0 6.96 381.5286 675.2786 Tm [(ss)-0.6 (,)-1.6 ( 0)]TJ 0 Tc 0 Tw 1.81 0 Td [(-)5 (21 )]TJ -2.913 -1.81 Td [(d)4.3 (ays )]TJ 11.04 0 0 11.04 351.2857 650.7991 Tm [(\()-4 (\265g.d)1.6 (ay)10.9 (/)-4.6 (m)-4 (L)14.8 (\) )]TJ EMC /TH <>BDC 0.004 Tc -0.015 Tw 6.576 2.88 Td [(T)8 (i)-0.7 (me)2.3 ( to )]TJ 0.002 Tc -0.002 Tw 0.13 -1.152 Td [(st)-2 (ea)2 (d)3.6 (y)]TJ 0 Tc 0 Tw 2.717 0 Td (-)Tj 0.002 Tc -0.002 Tw -2.196 -1.141 Td [(st)-2 (a)2 (t)9 (e )]TJ -0.413 -1.163 Td [(\()8.9 (w)-4.2 (eek)3.7 (\) )]TJ EMC /TH <>BDC -0.004 Tc 0.004 Tw 4.837 4.022 Td [(To)-4 (t)-8 (a)-4 (l)-8.6 ( C)0.6 (L )]TJ 0 Tc 0 Tw 0.196 -1.141 Td [(r)-1.6 (an)1.6 (ge)-1.7 ( a)10.9 (t )]TJ 0.002 Tc -0.002 Tw 0.239 -1.141 Td [(st)-2 (ea)2 (d)3.6 (y)]TJ 0 Tc 0 Tw 2.717 0 Td (-)Tj 0.002 Tc -0.002 Tw -2.196 -1.152 Td [(st)-2 (a)2 (t)9 (e )]TJ -0.011 Tc 0.011 Tw -0.576 -1.152 Td [(\()-15 (L)-7 (/)-15.6 (d)-9.4 (a)-11 (y\) )]TJ EMC /TD <>BDC /TT0 1 Tf -34.661 -1.751 Td [(4)-11 ( m)-4.7 (g/)-15.6 (k)-11 (g )]TJ 0 Tc 0 Tw 0.978 -1.141 Td [(+)-1.2 ( 2 )]TJ -0.011 Tc 0.011 Tw -0.609 -1.152 Td [(m)-4.7 (g/)-15.6 (k)-11 (g )]TJ 0 Tc 0 Tw 0.663 -1.152 Td (qw )Tj EMC /TD <>BDC 0.002 Tc 4.706 2.304 Td [(B)6 (r)-2 (eas)10.6 (t )]TJ -0.022 -1.163 Td [(can)2 (ce)11.2 (r )]TJ EMC /TD <>BDC 0 Tc 4.761 0.576 Td (1195 )Tj EMC /TD <>BDC 3.902 1.152 Td (66.1 )Tj -0.685 -1.141 Td [(\()-4 (14.9 )11 (t)-4.6 (o )]TJ 0.641 -1.152 Td (142\) )Tj EMC /TD <>BDC 4.761 2.293 Td (109 )Tj -0.804 -1.141 Td [(\()-4 (51.0 )11 (t)-4.6 (o )]TJ 0.641 -1.152 Td (209\) )Tj EMC /TD <>BDC 5.359 2.293 Td (1765 )Tj -0.435 -1.141 Td [(\()-4 (647 )]TJ 0.005 Tc -0.005 Tw 2.076 0 Td (to )Tj 0 Tc 0 Tw -1.815 -1.152 Td (3578\) )Tj EMC /TD <>BDC 6.239 1.141 Td (12 )Tj EMC /TD <>BDC 4.25 0.587 Td (0.201 )Tj -0.006 Tc 0.006 Tw (to )Tj 0 Tc 0 Tw 0.511 -1.163 Td (0.244 )Tj EMC /StyleSpan <>BDC 6.48 0 0 6.48 92.6886 568.8386 Tm (a )Tj EMC /P <>BDC 0.002 Tc -0.002 Tw 9.96 0 0 9.96 98.0885 565.3586 Tm [(S)3.8 (t)2.9 (ead)-16.1 (y)]TJ 0 Tc 0 Tw 2.723 0 Td (-)Tj 0.002 Tc 0.001 Tw 0.337 0 Td [(s)5.5 (t)2.9 (at)2.9 (e t)2.9 (r)-2.4 (o)-4 (u)-4.1 (g)-4 (h)8 ( s)5.5 (er)-2.3 (u)-4.1 (m)9 ( co)-16.1 (n)8 (cen)8.1 (t)2.9 (r)-2.4 (at)-9.1 (i)2.9 (o)-4.1 (n)8.1 ( o)-4 (f)9.7 ( t)2.9 (r)-2.3 (as)5.4 (t)-9.1 (u)8 (z)-11.8 (u)-4.1 (m)8.9 (ab )]TJ EMC /StyleSpan <>BDC 0 Tc 0 Tw 6.48 0 0 6.48 92.6886 557.4386 Tm (b )Tj EMC /P <>BDC 0.002 Tc 0.001 Tw 9.96 0 0 9.96 98.4485 553.9586 Tm [(M)-0.6 (ax)8.1 (i)-9.2 (m)8.9 (u)-4 (m)8.9 ( s)-6.6 (t)2.9 (ead)-16 (y)]TJ 0 Tc 0 Tw 7 0 Td (-)Tj -0.001 Tc 0.004 Tw 0.325 0 Td [(s)2.4 (ta)-2.8 (te )-14.8 (s)2.4 (e)-2.8 (r)-5.3 (u)-7.1 (m)6 ( c)-2.8 (o)-7 (n)5 (c)-2.8 (e)-14.8 (n)5 (tr)-5.4 (a)-2.8 (tio)-7 (n)5 ( o)-7 (f)6.6 ( tr)-5.3 (a)-14.9 (s)2.5 (tu)5.1 (z)-14.9 (u)-7 (m)5.9 (a)-14.8 (b )]TJ EMC /P <>BDC /TT2 1 Tf 0 Tc 0 Tw 12 0 0 12 92.6886 528.3986 Tm [(Spe)4 (c)4 (i)-2 (f)-2 (i)-2 (c)4 ( P)1 (opul)-2 (at)-2 (i)-2 (ons )]TJ EMC /P <>BDC /TT0 1 Tf 0 -1.67 TD [(B)7 (a)4 (s)-1 (e)4 (d on )-10 (a)4 ( popul)-2 (a)4 (t)-2 (i)-2 (on )]TJ -0.004 Tc 0.004 Tw [(p)-4 (h)-14 (ar)-1 (m)-6 (aco)-4 (k)-4 (i)-6 (n)-4 (et)-6 (i)-6 (c )-10 (an)-4 (al)-26 (y)16 (s)-4.9 (i)-6.1 (s)-5 (,)-3.9 ( n)-13.9 (o)-4 ( cl)-6 (i)-6 (n)-4 (i)-6 (cal)-6 (l)-16 (y)16 ( s)-5 (i)-16 (g)6 (n)-4 (i)-6 (f)-1 (i)-6 (can)-4 (t)-6 ( d)-4 (i)-16 (f)-1 (f)-1 (er)-11 (en)-4 (ces )-15 (w)-2 (er)-11 (e )]TJ EMC /P <>BDC /C2_0 1 Tf 0 Tc -0.004 Tw 0 -1.16 TD [<005200450056>-1 <0048>4 <0055>3 <00590048>4 <00470003004C>-2 <005100030057>-2 <004B0048>4 <00030053004B0044>-6 <0055>3 <0050>-2 <0044>4 <0046>-6 <0052004E004C>-2 <00510048>4 <0057>-2 <004C>-2 <0046>4 <0056>-1 <000300520049>3 <00030057>-2 <0055>3 <0044>4 <0056>-1 <0057>-2 <0058005D>-6 <00580050>-2 <0044>4 <0045000300450044>4 <0056>-1 <0048>4 <004700030052005100030044>-6 <004A>10 <00480003>-6 <000B>3 <001F>4 <0003001900180003>-10 <000B>3 <00510020>4 <00140015>-10 <001C0017000C>3 <001E>-2 <00030095>-1 <0003001900180003000B>3 <00510020>4 <0015001B001B000C>3 <000C>3 <000F0003>]TJ EMC /P <>BDC /TT0 1 Tf 0 Tw 0 -1.17 TD [(r)3 (a)4 (c)4 (e )-6 (\()3 (A)2 (s)-1 (i)-2 (a)4 (n \()3 (n)-10 (=)4 (264\))3 (;)-2 ( non)-10 (-)]TJ -0.004 Tc 0.004 Tw 10.42 0 Td [(A)-2 (s)-5 (i)-6 (an)-4 ( \()-1 (n)-4 (=1)-4 (3)-4 (2)-4 (4)-14 (\))-1 (\))-1 ( an)-4 (d )-14 (r)-1 (en)-14 (al)-6 ( i)-5.9 (m)-6.1 (p)-3.9 (ai)-6 (r)-1 (m)-6 (en)-4 (t)-6 ( \()-1 (m)-6 (i)-6 (l)-6 (d)-4 ( \()-1 (cr)-1 (e)-10 (at)-6 (i)-6 (n)-4 (i)-6 (n)-4 (e cl)-6 (ear)-11 (an)-4 (c)-10 (e )]TJ -0.021 Tc 0.021 Tw -10.42 -1.17 Td [([)-28 (C)-24 (Lc)-27 (r)]TJ 0 Tc 0 Tw 2.38 0 Td [(])-7 ( 60 t)-2 (o 90 m)-12 (L)21 (/)-2 (m)-2 (i)-2 (n\))3 ( \()3 (n=)4 (636\))3 ( or)3 ( m)-2 (od)-10 (e)4 (r)3 (a)4 (t)-2 (e )-6 (\()3 (C)-3 (L)11 (c)-6 (r)3 ( 30 t)-2 (o 60 m)-12 (L)21 (/)-2 (m)-2 (i)-2 (n\))3 ( \()3 (n)-10 (=)4 (133\))3 (\))3 (. T)1 (h)-10 (e )]TJ -2.38 -1.16 Td [(pha)4 (r)3 (m)-2 (a)4 (c)4 (oki)-2 (ne)4 (t)-2 (i)-2 (c)4 (s)-1 ( o)-10 (f)3 ( t)-2 (r)3 (a)4 (s)-1 (t)-12 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (s)-1 ( i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h s)-1 (e)4 (ve)4 (r)3 (e)4 ( r)-7 (e)4 (na)4 (l)-2 ( i)-2 (m)-2 (pa)4 (i)-2 (r)3 (m)-2 (e)4 (nt)-2 (, e)4 (nd-)]TJ -0.004 Tc 0.004 Tw 35.56 0 Td [(s)-5 (t)-6 (a)-10 (g)-4 (e )]TJ 0 Tc 0 Tw -35.56 -1.17 Td [(r)3 (e)4 (na)4 (l)-2 ( di)-2 (s)-1 (e)4 (a)4 (s)-11 (e)4 ( w)2 (i)-2 (t)-2 (h or)3 ( w)2 (i)-2 (t)-12 (hout)-2 ( he)4 (m)-2 (odi)-2 (a)4 (l)-12 (y)20 (s)-1 (i)-2 (s)-1 (, or)3 ( he)-6 (pa)4 (t)-2 (i)-2 (c)4 ( i)-2 (m)-2 (pa)4 (i)-2 (r)3 (m)-2 (e)4 (nt)-2 ( i)-2 (s)-1 ( unknow)2 (n. )]TJ EMC /P <>BDC /TT2 1 Tf 0 -1.67 TD [(D)2 (r)-1 (ug I)3 (nt)-2 (e)4 (r)-1 (ac)4 (t)-2 (i)-2 (on St)-2 (udi)-2 (e)4 (s )]TJ EMC /P <>BDC /TT0 1 Tf 0 -1.66 TD [(T)1 (he)4 (r)3 (e)4 ( h)-10 (a)4 (ve)4 ( be)-6 (e)4 (n no f)3 (or)3 (m)-12 (a)4 (l)-2 ( dr)3 (ug)10 ( i)-2 (nt)-2 (e)-6 (r)3 (a)-6 (c)4 (t)-2 (i)-2 (on s)-1 (t)-2 (udi)-2 (e)4 (s)-1 ( pe)4 (r)3 (f)3 (or)3 (m)-2 (e)4 (d )-10 (w)2 (i)-2 (t)-2 (h t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (s)-1 ( i)-2 (n )]TJ 0.002 Tc -0.002 Tw 0 -1.17 TD [(h)2 (u)2 (ma)6 (n)2 (s)1 (.)2 ( C)-1 (lin)2 (ic)6 (a)6 (ll)-10 (y)22 ( s)1 (ig)12 (n)2 (if)-5 (ic)6 (a)6 (n)2 (t in)2 (te)6 (r)5 (a)6 (c)6 (tio)2 (n)2 (s)1 ( b)2 (e)5.9 (tw)-6 (e)5.9 (e)-3.9 (n)2 ( tr)5.1 (a)5.9 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b)2 ( a)6 (n)2 (d)2 ( c)6 (o)2 (n)2 (c)6 (o)-8 (mita)6 (n)2 (t me)6 (d)2 (ic)6 (a)6 (tio)2 (n)2 (s )]TJ 0 Tc 0 Tw T* [(us)-1 (e)4 (d i)-2 (n c)4 (l)-2 (i)-2 (ni)-2 (c)4 (a)4 (l)-2 ( t)-2 (r)3 (i)-2 (a)4 (l)-2 (s)-1 ( ha)4 (v)-10 (e)4 ( not)-2 ( be)4 (e)4 (n obs)-1 (e)-6 (r)3 (ve)4 (d. )]TJ EMC /P <>BDC /TT2 1 Tf 0 -1.66 TD [(P)1 (ac)4 (l)-2 (i)-2 (t)-2 (ax)4 (e)4 (l)-2 ( and dox)4 (or)-1 (ubi)-2 (c)-6 (i)-2 (n: )]TJ /TT0 1 Tf 11.47 0 Td [(C)-3 (onc)4 (e)4 (nt)-2 (r)3 (a)4 (t)-2 (i)-2 (ons)-1 ( of)3 ( pa)-6 (c)-6 (l)-2 (i)-2 (t)-2 (a)4 (x)-10 (e)4 (l)-2 ( a)4 (nd do)10 (x)-10 (or)3 (ubi)-2 (c)4 (i)-2 (n a)4 (nd t)-2 (he)4 (i)-2 (r)3 ( m)-2 (a)4 (j)-2 (or )]TJ 0.002 Tc -0.002 Tw -11.47 -1.17 Td [(me)6 (ta)6 (b)2 (o)2 (lite)6 (s)1 ( \()5 (i.)2 (e)6 (.)2 (,)2 ( 6)]TJ 0 Tc 0 Tw 7.41 0 Td (-)Tj /C2_0 1 Tf 0.33 0 Td [<012E>4 <0003004B>-20 <005C>20 <0047>-10 <0055>3 <0052005B>-20 <005C>30 <004F>]TJ /TT0 1 Tf 4.38 0 Td [(-)3 (p)-10 (a)4 (c)4 (l)-2 (i)-2 (t)-2 (a)4 (x)-10 (e)4 (l)-2 ( [)-7 (P)-4 (O)2 (H)2 (])-7 (, a)14 (nd dox)-10 (or)3 (ubi)-2 (c)4 (i)-2 (nol )8 ([)-7 (D)2 (O)-8 (L)21 (])-7 (, r)3 (e)4 (s)-1 (pe)4 (c)4 (t)-2 (i)-2 (ve)4 (l)-22 (y)20 (\) )-7 (w)2 (e)4 (r)-7 (e )]TJ -12.12 -1.17 Td [(not)-2 ( a)4 (l)-2 (t)-2 (e)4 (r)3 (e)4 (d i)-2 (n t)-2 (he)4 ( pr)-7 (e)4 (s)-1 (e)4 (nc)-6 (e)4 ( of)3 ( t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b w)2 (he)4 (n us)-11 (e)4 (d a)4 (s)-1 ( c)4 (om)-2 (bi)-2 (na)4 (t)-2 (i)-2 (on t)-2 (he)4 (r)-7 (a)]TJ 0.002 Tc -0.002 Tw 29.79 0 Td [(p)-8 (y )12 (in)2 ( c)6 (lin)2 (ic)6 (a)6 (l tr)5 (ia)6 (ls)1 (. )]TJ 0 Tc 0 Tw -29.79 -1.17 Td [(T)1 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b c)4 (onc)4 (e)4 (nt)-2 (r)-7 (a)4 (t)-2 (i)-2 (ons)-1 ( w)2 (e)4 (r)3 (e)4 ( not)-2 ( a)4 (l)-2 (t)-2 (e)-6 (r)3 (e)4 (d a)4 (s)-1 ( p)-10 (a)4 (r)3 (t)-2 ( of)3 ( t)-2 (hi)-2 (s)-1 ( c)4 (om)-2 (bi)-2 (na)4 (t)-2 (i)-2 (on t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 (. )]TJ EMC /P <>BDC /TT2 1 Tf T* [(D)2 (oc)4 (e)4 (t)-2 (ax)-6 (e)4 (l)-2 ( and c)4 (ar)-1 (bopl)-2 (at)-2 (i)-2 (n: )]TJ /TT0 1 Tf 11.3 0 Td [(W)-6 (he)4 (n t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b w)2 (a)4 (s)-1 ( a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d i)-2 (n c)4 (om)-2 (bi)-2 (na)4 (t)-2 (i)-2 (on w)2 (i)-2 (t)-2 (h doc)4 (e)4 (t)-2 (a)4 (x)-10 (e)4 (l )]TJ -11.3 -1.17 Td [(or)3 ( c)4 (a)4 (r)3 (bopl)-12 (a)4 (t)-2 (i)-2 (n, ne)4 (i)-2 (t)-2 (he)4 (r)3 ( t)-2 (h)-10 (e)4 ( pl)-2 (a)4 (s)-1 (m)-2 (a)4 ( c)4 (onc)-6 (e)4 (nt)-2 (r)3 (a)4 (t)-2 (i)-2 (ons )-11 (of)3 ( doc)4 (e)4 (t)-2 (a)4 (x)-10 (e)4 (l)-2 ( or)3 ( c)-6 (a)4 (r)3 (bopl)-2 (a)4 (t)-12 (i)-2 (n nor)3 ( t)-2 (he)4 ( pl)-2 (a)4 (s)-1 (m)-2 (a )]TJ -0.004 Tc 0.004 Tw 0 -1.17 TD [(co)-4 (n)-4 (cen)-4 (t)-6 (r)-11 (at)-6 (i)-6 (o)-4 (n)-4 (s)-5 ( o)-4 (f)-1 ( t)-6 (r)-1 (as)-5 (t)-6 (u)-4 (z)-9.9 (u)-4 (m)-6.1 (ab)-4 ( w)-2 (er)-1 (e )-10 (al)-6 (t)-6 (er)-11 (ed)-4 (. )]TJ EMC /P <>BDC /TT1 1 Tf 0.004 Tc 0 Tw 14.04 0 0 14.04 92.6886 220.7186 Tm (13 )Tj -0.004 Tc 0.002 Tw 3.846 0 Td [(NO)-3.7 (NCL)-3.7 (I)-8.2 (NI)-8.1 (CAL)-3.6 ( T)-3.6 (O)-3.8 (XI)-8.1 (C)]TJ 0 Tc 0 Tw (OLOGY )Tj EMC /Span <>BDC 0.004 Tc -3.846 -2.009 Td [(13.)14.7 (1 )]TJ EMC /Span <>BDC -0.006 Tw 3.847 0 Td [(C)8.1 (ar)3.5 (c)3.6 (i)8.5 (n)4.4 (o)8.3 (ge)3.6 (n)4.4 (e)12.1 (s)8.4 (is,)6.1 ( M)7.9 (u)13 (t)3.6 (ag)8.3 (e)3.6 (n)4.4 (e)12.1 (si)8.5 (s,)6.1 ( Im)16.5 (p)4.4 (air)3.5 (m)16.5 (e)3.6 (n)4.4 (t)3.7 ( of)3.7 ( F)8.1 (e)3.6 (r)3.5 (t)12.2 (il)8.5 (it)12.2 (y )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw 12 0 0 12 92.6886 172.1186 Tm [(T)1 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (s )-1 (ha)-6 (ve)4 ( not)-2 ( be)4 (e)4 (n t)-2 (e)4 (s)-1 (t)-2 (e)4 (d )-10 (f)3 (or)3 ( c)-6 (a)4 (r)-7 (c)4 (i)-2 (noge)4 (ni)-2 (c)4 ( pot)-2 (e)4 (nt)-2 (i)-2 (a)4 (l)-2 (. )]TJ EMC /P <>BDC 0 -1.66 TD [(N)2 (o e)4 (vi)-2 (de)4 (nc)-6 (e)4 ( of)3 ( m)-2 (ut)-2 (a)-6 (g)10 (e)4 (ni)-12 (c)4 ( a)4 (c)4 (t)-2 (i)-2 (vi)-2 (t)-12 (y )10 (w)2 (a)4 (s)-1 ( obs)-1 (e)4 (r)3 (v)-10 (e)4 (d )-10 (w)2 (he)4 (n t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b w)2 (a)4 (s)-1 ( t)-2 (e)-6 (s)-1 (t)-2 (e)4 (d i)-2 (n t)-2 (he)4 ( s)-1 (t)-2 (a)4 (nda)4 (r)3 (d )]TJ 0 -1.17 TD [(A)2 (m)-2 (e)4 (s)-1 ( ba)4 (c)4 (t)-2 (e)-6 (r)3 (i)-2 (a)4 (l)-2 ( a)4 (nd hum)-2 (a)-6 (n pe)4 (r)3 (i)-2 (phe)4 (r)-7 (a)4 (l)-2 ( bl)-2 (ood l)-12 (y)20 (m)-2 (ph)-10 (oc)-6 (y)20 (t)-12 (e)4 ( m)-2 (ut)-2 (a)-6 (g)10 (e)4 (ni)-2 (c)4 (i)-2 (t)-22 (y)20 ( a)4 (s)-1 (s)-1 (a)-16 (y)10 (s)-1 (, a)4 (t)-2 ( c)4 (onc)4 (e)4 (nt)-2 (r)-7 (a)4 (t)-2 (i)-2 (ons )]TJ 0 -1.16 TD [(of)3 ( up t)-2 (o 5000 m)-2 (c)4 (g)10 (/)-2 (m)-12 (L)11 (. )-10 (I)3 (n a)4 (n )]TJ /TT2 1 Tf -0.004 Tc 0.004 Tw [(i)-6 (n)-4 ( vi)-6 (vo )]TJ /TT0 1 Tf 0 Tc 0 Tw 14.71 0 Td [(m)-2 (i)-2 (c)4 (r)3 (onuc)4 (l)-12 (e)4 (u)-10 (s)-1 ( a)4 (s)-1 (s)-1 (a)-16 (y)20 (, no e)4 (vi)-2 (de)4 (n)-10 (c)4 (e)4 ( of )-7 (c)-6 (hr)3 (om)-2 (os)-1 (om)-2 (a)4 (l)-2 ( da)4 (m)-2 (a)-6 (g)10 (e)4 ( t)-2 (o )]TJ -14.71 -1.17 Td [(m)-2 (ous)-1 (e )4 (bone)4 ( m)-2 (a)4 (r)3 (r)3 (o)-10 (w)2 ( c)4 (e)4 (l)-2 (l)-12 (s)-1 ( w)2 (a)4 (s)-1 ( obs)-1 (e)4 (r)3 (ve)4 (d )-10 (f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng bol)-2 (us)-1 ( i)-2 (nt)-2 (r)3 (a)4 (ve)4 (nous)-1 ( dos)-1 (e)4 (s )-11 (of)3 ( up t)-2 (o 118 )]TJ -0.01 Tc 0.01 Tw [(m)-12 (g/)-12 (k)-20 (g o)-10 (f )]TJ 0 Tc 0 Tw 0 -1.17 TD [(t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b. )]TJ EMC /Artifact <>BDC 19 -3.39 Td (22)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 30.6886 26.8386 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4630 0 obj <>>>/Resources 4526 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4631 0 obj <> endobj 4632 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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44.04 re f 308.28 124.08 0.72 0.72 re f 309 124.08 69.241 0.72 re f 378.24 124.8 0.72 44.04 re f 378.24 124.08 0.72 0.72 re f 378.96 124.08 132.96 0.72 re f 511.92 124.8 0.72 44.04 re f 511.92 124.08 0.72 0.72 re f 511.92 124.08 0.72 0.72 re f q 1 0 0 1 -21.048737 -16.390259 cm BT /TT0 1 Tf 3 Tr 12 0 0 12 93.0487 123.0703 Tm ( )Tj ET Q EMC 1 0 0 1 -21.048737 -16.390259 cm BT /Span <>BDC /TT1 1 Tf 0.004 Tc 14.04 0 0 14.04 93.0487 723.3103 Tm (12 )Tj EMC /Span <>BDC -0.004 Tc 0.002 Tw 3.846 0 Td [(CL)-3.6 (I)-8.2 (NI)-8.2 (CAL)-3.6 ( PH)-3.8 (ARMACO)]TJ 0 Tc 0 Tw 11.214 0 Td (LOGY )Tj EMC /Span <>BDC 0.004 Tc -15.06 -2 Td [(12.)14.7 (1 )]TJ EMC /Span <>BDC -0.004 Tc 0.002 Tw 3.847 0 Td [(Me)-4.4 (c)-4.4 (h)-3.6 (a)-8.3 (n)5 (i)-8 (s)-8.2 (m)8.5 ( o)-8.3 (f)-4.3 ( Ac)-4.4 (t)-4.4 (i)0.5 (on )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw 12 0 0 12 93.0487 674.8303 Tm [(T)1 (he)4 ( H)2 (E)1 (R)-3 (2 \()3 (or )-7 (c)4 (-)]TJ -0.003 Tc 0.013 Tw 6.74 0 Td [(e)-9 (rb)-3 (B)4 (2)-13 (\) p)-3 (ro)-3 (t)-5 (o)]TJ 0 Tc 0 Tw 5.15 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.33 0 Td [(o)-4 (n)-4 (co)-14 (g)6 (en)-14 (e en)-4 (co)-4 (d)-14 (es )-15 (a t)-6 (r)-1 (an)-4 (s)-4.9 (m)-6.1 (em)-6 (b)-3.9 (r)-1 (an)-14 (e r)-11 (ecep)-4 (t)-6 (o)-14 (r)-1 ( p)-4 (r)-1 (o)-4 (t)-6 (ei)-6 (n)-4 ( o)-4 (f)-1 ( 1)-4 (8)-4 (5 )]TJ 0 Tc 0 Tw 24.1 0 Td [(kD)-8 (a)4 (, )]TJ -0.004 Tc 0.004 Tw -36.32 -1.17 Td [(w)-2 (h)-4 (i)-6 (ch)-4 ( i)-6 (s)-5 ( s)-5 (t)-6 (r)-1 (u)-4 (ct)-6 (u)-4 (r)-1 (al)-6 (l)-26 (y)16 ( r)-1 (el)-6 (at)-16 (ed)-3.9 ( t)-6 (o)-4 ( t)-6 (h)-4 (e ep)-4 (i)-6 (d)-4 (er)-1 (m)-6 (al )-16 (g)-4 (r)-1 (o)-4 (w)-12 (t)-6 (h)-4 ( f)-1 (act)-6 (o)-4 (r)-1 ( r)-11 (ecep)-4 (t)-6 (o)-14 (r)-1 (. )]TJ 0 Tc 0 Tw 27.57 0 Td [(T)1 (r)3 (a)4 (s)-1 (t)-2 (u)-10 (z)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (s )-1 (ha)4 (ve )]TJ -27.57 -1.16 Td [(be)4 (e)4 (n s)-1 (how)2 (n, i)-2 (n bot)-2 (h )]TJ /TT2 1 Tf 0.002 Tc -0.002 Tw [(in)2 ( v)6 (itr)1 (o )]TJ /TT0 1 Tf 0 Tc 0 Tw 11.47 0 Td [(a)4 (s)-1 (s)-1 (a)-6 (y)20 (s )-11 (a)4 (nd i)-2 (n a)4 (ni)-2 (m)-2 (a)4 (l)-2 (s)-1 (, t)-2 (o i)-2 (nhi)-2 (bi)-2 (t)-2 ( t)-2 (he)4 ( pr)3 (ol)-2 (i)-2 (f)3 (e)4 (r)3 (a)4 (t)-2 (i)-2 (on of)3 ( hum)-2 (a)4 (n t)-2 (um)-2 (or )]TJ -0.004 Tc 0.004 Tw -11.47 -1.17 Td [(cel)-6 (l)-6 (s)-5 ( t)-6 (h)-4 (at)-6 ( o)-4 (v)-4 (er)-1 (ex)-14 (p)-4 (r)-1 (es)-5 (s)-5 ( H)-2 (E)-13 (R)-6.9 (2)-4 (. )]TJ EMC /P <>BDC 0 Tc 0 Tw 0 -1.67 TD [(T)1 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (s)-1 ( a)4 (r)-7 (e )4 (m)-2 (e)4 (di)-2 (a)4 (t)-2 (or)3 (s)-1 ( of)3 ( a)4 (nt)-2 (i)-2 (bod)-20 (y)20 (-)-7 (de)4 (pe)4 (nde)4 (nt)-2 ( c)-6 (e)4 (l)-2 (l)-2 (ul)-2 (a)4 (r)3 ( c)-16 (y)20 (t)-2 (ot)-2 (o)-10 (x)-10 (i)-2 (c)4 (i)-2 (t)-12 (y)30 ( \()3 (A)-8 (D)2 (C)-3 (C)-3 (\))3 (. )]TJ /TT2 1 Tf -0.003 Tc (In )Tj 0.002 Tc 0 -1.16 TD [(v)6 (itr)1 (o)]TJ /TT0 1 Tf 0 Tc 1.89 0 Td [(, t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (-)]TJ -0.004 Tc 0.004 Tw 9.02 0 Td [(m)-6 (ed)-4 (i)-6 (at)-6 (ed)-4 ( A)-2 (D)-2 (C)-7 (C)-7 ( h)-4 (as)-5 ( b)-14 (een)-4 ( s)-5 (h)-4 (o)-4 (w)-1.9 (n)-4 ( t)-6.1 (o)-3.9 ( b)-4 (e p)-4 (r)-11 (ef)-11 (er)-1 (en)-14 (t)-6 (i)-6 (al)-6 (l)-16 (y)16 ( ex)-14 (er)-1 (t)-6 (ed )]TJ 0 Tc 0 Tw 24.57 0 Td (on )Tj -35.48 -1.17 Td [(H)2 (E)1 (R)-3 (2 ove)4 (r)3 (e)4 (x)-10 (pr)3 (e)4 (s)-1 (s)-1 (i)-2 (ng c)4 (a)-6 (nc)4 (e)4 (r)3 ( c)-6 (e)4 (l)-2 (l)-2 (s)-1 ( c)4 (om)-2 (pa)4 (r)-7 (e)4 (d w)2 (i)-2 (t)-2 (h c)4 (a)4 (nc)-6 (e)4 (r)3 ( c)-6 (e)4 (l)-2 (l)-2 (s)-1 ( t)-2 (ha)4 (t)-2 ( do not)-2 ( ove)4 (r)3 (e)4 (x)-10 (pr)3 (e)4 (s)-1 (s)-1 ( H)2 (E)1 (R)-3 (2. )]TJ EMC /Span <>BDC /TT1 1 Tf 0.004 Tc 14.04 0 0 14.04 93.0487 557.1103 Tm [(12.)14.7 (2 )]TJ EMC /Span <>BDC 3.847 0 Td [(P)8.2 (h)4.4 (ar)3.6 (m)16.5 (ac)3.5 (od)13 (yn)13 (am)16.5 (ic)3.6 (s )]TJ EMC /P <>BDC /TT2 1 Tf 0 Tc 12 0 0 12 93.0487 536.7103 Tm [(C)-3 (ar)-1 (di)-2 (ac)4 ( E)1 (l)-2 (e)4 (c)4 (t)-2 (r)-1 (ophy)4 (s)-1 (i)-2 (ol)-2 (ogy )]TJ EMC /P <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 0 -1.66 TD [(T)-3 (h)-4 (e ef)-1 (f)-11 (ect)-6 (s)-5 ( o)-4 (f)-1 ( t)-6 (r)-11 (as)-5 (t)-6 (u)-4 (z)-10 (u)-4 (m)-6 (ab )]TJ 0 Tc 0 Tw 10.94 0 Td [(on e)4 (l)-2 (e)4 (c)4 (t)-2 (r)3 (oc)-6 (a)4 (r)3 (di)-2 (o)-10 (g)10 (r)-7 (a)4 (phi)-2 (c)-6 ( \()3 (E)1 (C)-3 (G)2 (\))3 ( e)4 (ndpoi)-2 (nt)-2 (s)-1 (, i)-2 (nc)4 (l)-2 (udi)-2 (ng)10 ( Q)2 (T)1 (c)4 ( i)-2 (nt)-2 (e)-6 (r)3 (va)4 (l )]TJ -10.94 -1.17 Td [(dur)3 (a)4 (t)-2 (i)-2 (on, w)2 (e)4 (r)-7 (e)4 ( e)4 (va)4 (l)-2 (u)-10 (a)4 (t)-2 (e)4 (d )-10 (i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h H)2 (E)1 (R)-3 (2 pos)-1 (i)-2 (t)-2 (i)-2 (ve)4 ( s)-1 (ol)-2 (i)-2 (d t)-2 (um)-2 (or)3 (s)-1 (. T)1 (r)3 (a)4 (s)-1 (t)8 (uz)-6 (um)-2 (a)4 (b ha)4 (d no )]TJ -0.004 Tc 0.004 Tw 0 -1.17 TD [(cl)-6 (i)-6 (n)-4 (i)-6 (cal)-6 (l)-16 (y)16 ( r)-11 (el)-6 (ev)-4 (an)-4 (t )-16 (ef)-1 (f)-11 (ect )-15.9 (o)-4.1 (n)-3.9 ( t)-6 (h)-4 (e Q)-2 (T)-3 (c i)-6 (n)-4 (t)-6 (er)-1 (v)-14 (al)-6 ( d)-4 (u)-4 (r)-1 (at)-16 (i)-6 (o)-4 (n)-4 ( an)-4 (d)-4 ( t)-6 (h)-4 (er)-1 (e w)-12 (as)-5 ( n)-4 (o)-4 ( ap)-4 (p)-14 (ar)-0.9 (en)-4 (t)-5.9 ( r)-11 (el)-6 (at)-6 (i)-6 (o)-4 (n)-4 (s)-5 (h)-4 (i)-6 (p )]TJ 0 -1.16 TD [(b)-4 (et)-6 (w)-2 (een )]TJ 0 Tc 0 Tw 3.57 0 Td [(s)-1 (e)-6 (r)3 (um)-2 ( t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b c)4 (onc)-6 (e)4 (nt)-2 (r)3 (a)4 (t)-2 (i)-2 (ons)-1 ( a)4 (nd c)4 (h)-10 (a)4 (nge)4 ( i)-2 (n Q)2 (T)1 (c)-6 (F)6 ( i)-2 (nt)-2 (e)4 (r)3 (v)-10 (a)4 (l)-2 ( dur)3 (a)4 (t)-2 (i)-2 (on i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h )]TJ -3.57 -1.17 Td [(H)2 (E)1 (R)-3 (2 pos)-1 (i)-2 (t)-2 (i)-2 (ve)4 ( s)-1 (ol)-2 (i)-2 (d t)-2 (um)8 (or)3 (s)-1 (. )]TJ EMC /Span <>BDC /TT1 1 Tf 0.004 Tc 14.04 0 0 14.04 93.0487 433.0303 Tm [(12.)14.7 (3 )]TJ EMC /Span <>BDC 3.847 0 Td [(P)8.2 (h)4.4 (ar)3.6 (m)16.5 (ac)3.5 (ok)21.5 (in)4.4 (e)3.5 (t)3.7 (ic)12.1 (s )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 12 0 0 12 93.0487 412.6304 Tm [(T)1 (he)4 ( pha)4 (r)3 (m)-2 (a)-6 (c)4 (oki)-2 (ne)4 (t)-2 (i)-2 (c)4 (s)-1 ( of )-7 (t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b w)2 (e)4 (r)3 (e)4 ( e)4 (v)-10 (a)4 (l)-2 (ua)4 (t)-12 (e)4 (d i)-2 (n a)4 ( pool)-2 (e)4 (d popul)-2 (a)4 (t)-2 (i)-2 (on)-10 ( pha)4 (r)3 (m)-2 (a)4 (c)4 (oki)-2 (ne)4 (t)-2 (i)-2 (c )]TJ 0 -1.17 TD [(\()3 (P)-4 (K)2 (\))3 ( m)-2 (ode)4 (l)-2 ( a)4 (na)4 (l)-22 (y)20 (s)-1 (i)-2 (s)-1 ( of)3 ( 1)-10 (,582 )]TJ -0.004 Tc 0.004 Tw [(s)-5 (u)-4 (b)-4 (j)-6 (ect)-6 (s)-5 ( w)-2 (i)-6 (t)-6 (h)-4 ( p)-4 (r)-1 (i)-6 (m)-6 (ar)-11 (i)-6 (l)-16 (y)16 ( b)-4 (r)-1 (e)-10 (as)-4.9 (t)-6 ( can)-14 (cer )]TJ 0 Tc 0 Tw 26.96 0 Td [(o)-10 (r)3 ( a)4 (not)-2 (h)-10 (e)4 (r)3 ( i)-2 (ndi)-2 (c)4 (a)4 (t)-2 (i)-2 (on )]TJ 0.002 Tc -0.002 Tw -26.96 -1.16 Td [(r)5 (e)6 (c)6 (e)6 (iv)2 (in)-8 (g)12 ( in)2 (tr)5 (a)6 (v)-8 (e)6 (n)2 (o)2 (u)2 (s)1 ( tr)5 (a)-4 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b)2 (.)2 ( T)3 (o)2 (ta)6 (l tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)11.9 (ma)6 (b )]TJ -0.004 Tc 0.004 Tw 21.77 0 Td [(cl)-6 (ear)-11 (an)-4 (c)-10 (e i)-6 (n)-4 (cr)-1 (e)-10 (as)-5 (es )-15 (w)-2 (i)-6 (t)-6 (h)-4 ( d)-4 (ecr)-0.9 (e)-10 (as)-5 (i)-6 (n)-4 (g )]TJ 0 Tc 0 Tw -21.77 -1.17 Td [(c)4 (onc)4 (e)4 (nt)-2 (r)-7 (a)4 (t)-2 (i)-2 (ons)-1 ( due)4 ( t)-2 (o pa)4 (r)-7 (a)4 (l)-2 (l)-2 (e)4 (l)-2 ( l)-2 (i)-2 (ne)4 (a)4 (r)3 ( a)4 (nd non)-10 (-)]TJ 0.002 Tc -0.002 Tw 18.1 0 Td [(lin)2 (e)6 (a)-4 (r)5 ( e)6 (limin)2 (a)6 (tio)2 (n)2 ( p)2 (a)6 (th)2 (w)4 (a)-14 (y)22 (s)1 (. )]TJ EMC /P <>BDC 0 Tc 0 Tw -18.1 -1.67 Td [(P)-4 (r)3 (e)4 (di)-2 (c)4 (t)-2 (e)4 (d t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b e)4 (x)-10 (pos)-1 (ur)3 (e)4 ( a)4 (nd P)-4 (K)2 ( pa)-6 (r)3 (a)4 (m)-2 (e)4 (t)-2 (e)-6 (r)-7 (s)-1 ( f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng)10 ( t)-2 (he)4 ( f)3 (i)-2 (r)3 (s)-1 (t)-2 ( t)-2 (r)-7 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b c)-6 (y)20 (c)4 (l)-12 (e)4 ( a)4 (nd a)4 (t )]TJ -0.004 Tc 0.004 Tw T* [(s)-5 (t)-6 (ead)-14 (y)16 ( s)-5 (t)-16 (at)-6 (e ex)-14 (p)-4 (o)-4 (s)-5 (u)-4 (r)-1 (e ar)-10.9 (e )-9.9 (d)-4.1 (es)-5 (cr)-1 (i)-6 (b)-4 (ed)-4 ( i)-6 (n )-4 (T)-3 (ab)-4 (l)-16 (es)-5 ( 5 )-4 (an)-4 (d )]TJ 0 Tc 0 Tw 20.69 0 Td (6)Tj -0.004 Tc 0.004 Tw [(,)-4 ( r)-1 (es)-5 (p)-4 (ect)-6 (i)-6 (v)-4 (el)-26 (y)16 (. )]TJ EMC /P <>BDC 0 Tc 0 Tw -20.69 -1.66 Td [(P)-4 (opul)-2 (a)4 (t)-2 (i)-2 (on P)-4 (K)2 ( ba)4 (s)-1 (e)4 (d s)-1 (i)-2 (m)8 (ul)-2 (a)4 (t)-2 (i)-2 (ons)-1 ( i)-2 (ndi)-2 (c)4 (a)4 (t)-2 (e)4 ( t)-2 (ha)4 (t)-2 ( f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng)10 ( di)-2 (s)-1 (c)4 (ont)-2 (i)-2 (nua)4 (t)-2 (i)-2 (on of)-7 ( t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b, )]TJ -0.004 Tc 0.004 Tw T* [(co)-4 (n)-4 (cen)-4 (t)-6 (r)-11 (at)-6 (i)-6 (o)-4 (n)-4 (s)-5 ( i)-6 (n)-4 ( at)-6 ( l)-6 (eas)-5 (t)-6 ( 9)-3.9 (5)-4 (%)-1 ( o)-4 (f)-1 ( b)-4 (r)-1 (e)-10 (as)-5 (t)-6 ( can)-14 (cer)-1 ( p)-14 (at)-6 (i)-6 (en)-4 (t)-6 (s )]TJ 0 Tc 0 Tw 22.18 0 Td [(a)4 (nd pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h a)4 (n)-10 (ot)-2 (he)4 (r)3 ( i)-2 (ndi)-2 (c)4 (a)4 (t)-2 (i)-2 (on )]TJ 0.002 Tc -0.002 Tw [(w)4 (ill )]TJ -0.004 Tc 0.004 Tw -22.18 -1.16 Td [(d)-4 (ecr)-1 (e)-10 (as)-5 (e t)-6 (o)-4 ( ap)-4 (p)-14 (r)-1 (o)-4 (x)-14 (i)-6 (m)-6 (at)-6 (el)-6 (y )6.1 (3)-4 (%)-1.1 ( o)-13.9 (f)-1 ( t)-6 (h)-4 (e )]TJ 0 Tc 0 Tw [(popul)-2 (a)4 (t)-2 (i)-2 (on p)-10 (r)3 (e)4 (di)-2 (c)4 (t)-2 (e)4 (d s)-1 (t)-2 (e)-6 (a)4 (d)-20 (y)20 (-)]TJ 0.002 Tc -0.002 Tw 26.27 0 Td [(s)1 (ta)6 (te )]TJ 0 Tc 0 Tw 2.08 0 Td [(t)-2 (r)3 (ou)-10 (g)10 (h s)-1 (e)-6 (r)3 (um )]TJ -28.35 -1.17 Td [(c)4 (onc)4 (e)4 (nt)-2 (r)-7 (a)4 (t)-2 (i)-2 (on \()3 (a)4 (ppr)3 (ox)-10 (i)-2 (m)-2 (a)4 (t)-2 (e)4 (l)-12 (y)20 ( 97)-10 (%)3 ( w)2 (a)4 (s)-1 (hout)-2 (\))3 ( b)-20 (y)20 ( 7 )-10 (m)-2 (ont)-2 (hs )]TJ /TT2 1 Tf -0.004 Tc 0.004 Tw 23.25 0 Td [([)-5 (s)-5 (ee )]TJ 0 Tc 0 Tw 1.92 0 Td [(W)23 (ar)-1 (ni)-2 (ngs)-1 ( a)-10 (nd P)1 (r)-1 (e)4 (c)4 (aut)-2 (i)-2 (ons )-11 (\()13 (5.1)-10 (\) )]TJ /TT0 1 Tf -25.17 -1.17 Td [(a)4 (nd )]TJ /TT2 1 Tf [(U)2 (s)-1 (e)4 ( i)-2 (n Spe)-6 (c)4 (i)-2 (f)-2 (i)-2 (c)4 ( P)1 (opul)-2 (at)-2 (i)-2 (ons)-1 ( \()13 (8.1, 8.3)-10 (\))33 (])]TJ /TT0 1 Tf 17.09 0 Td (. )Tj EMC /Span <>BDC /TT1 1 Tf -17.09 -1.66 Td [(T)-3 (ab)-4 (l)-2 (e )4 (5:)]TJ /T1_0 1 Tf (\003 )Tj /TT1 1 Tf 0.004 Tc -0.004 Tw 6 0 Td [(P)15 (o)4 (pul)2 (a)4 (t)7 (i)2 (o)4 (n P)15 (r)-2 (e)8 (di)2 (c)8 (t)7 (e)8 (d C)-4 (y)3.9 (c)8.1 (l)1.9 (e)8 ( 1 )-5.9 (P)14.9 (K)12 ( E)1 (x)4 (po)4 (s)3 (ur)8 (e)8 (s)3 ( \()-3 (M)8 (e)8 (di)2 (a)4 (n w)-4 (i)2 (t)7 (h 5)]TJ EMC /StyleSpan <>BDC -0.005 Tc 0 Tw 8.04 0 0 8.04 471.1687 244.6303 Tm (th )Tj EMC /Span <>BDC 0 Tc 12 0 0 12 481.2487 240.6703 Tm (\226 95)Tj EMC /StyleSpan <>BDC -0.005 Tc 8.04 0 0 8.04 502.2487 244.6303 Tm (th )Tj EMC /Span <>BDC -0.004 Tc 0.004 Tw 12 0 0 12 165.0487 226.6303 Tm [(P)7 (e)-10 (rc)-10 (en)-8 (t)-1 (i)-6 (l)-6 (es)-5 (\))-1 ( i)-6 (n )-8 (B)-7 (rea)-4 (s)-5 (t)-1 ( C)-12 (a)-4 (n)-8 (cer )-10 (P)7 (a)-4 (t)-1 (i)-6 (en)-8 (t)-1 (s )]TJ EMC /TH <>BDC -0.002 Tc 0 Tw 11.04 0 0 11.04 104.8087 197.5903 Tm [(Sc)-3.7 (he)-3.7 (dul)4.3 (e )]TJ EMC /TH <>BDC 0 Tc 6.108 0.587 Td [(P)-8.6 (r)9.3 (i)-4.7 (m)7 (ar)-1.7 (y )]TJ 0.004 Tc -0.004 Tw -0.565 -1.163 Td [(tu)5.7 (mo)14.9 (r)2.3 ( ty)4 (p)16.5 (e )]TJ EMC /TH <>BDC 0 Tc 0 Tw 6.608 0.576 Td (N )Tj EMC /TH <>BDC 4.163 0.587 Td (C)Tj -0.005 Tc 6.96 0 0 6.96 292.8487 203.1103 Tm [(mi)-20.1 (n )]TJ 0 Tc 11.04 0 0 11.04 275.3321 191.2308 Tm [(\()-4 (\265g/)6.2 (m)-3.9 (L)3.9 (\) )]TJ EMC /TH <>BDC 7.152 1.163 Td (C)Tj -0.005 Tc 6.96 0 0 6.96 362.2087 203.1103 Tm [(ma)-22.2 (x )]TJ 0 Tc 11.04 0 0 11.04 345.2849 191.2308 Tm [(\()-4 (\265g/)6.2 (m)-3.9 (L)3.9 (\) )]TJ EMC /TH <>BDC -0.005 Tc 8.707 1.163 Td (AUC)Tj 0 Tc 6.96 0 0 6.96 465.1687 203.1103 Tm [(0-)5 (2)-17.2 (1d)4.2 (ays )]TJ 11.04 0 0 11.04 437.2063 191.2308 Tm [(\()-4 (\265g.d)1.6 (ay)10.9 (/)-4.6 (m)-4 (L)14.8 (\) )]TJ EMC /TD <>BDC /TT0 1 Tf -0.011 Tc 0.011 Tw -30.25 -2.315 Td [(4)-11 ( m)-4.7 (g/)-15.6 (k)-11 (g + )]TJ 0 Tc 0 Tw -0.326 -1.152 Td (2 )Tj -0.011 Tc 0.011 Tw [(m)-4.7 (g/)-15.6 (k)-11 (g q)-11 (w )]TJ EMC /TD <>BDC 0.002 Tc 0 Tw 7.098 1.152 Td [(B)6 (r)-2 (eas)10.6 (t )]TJ -0.022 -1.152 Td [(can)2 (ce)11.2 (r )]TJ EMC /TD <>BDC 0 Tc 4.902 0.565 Td (1195 )Tj EMC /TD <>BDC 4.826 1.163 Td (37.7 )Tj -0.685 -1.152 Td [(\()-4 (12.3 )11 (t)-4.6 (o )]TJ 0.511 -1.152 Td (70.9\) )Tj EMC /TD <>BDC 6.5 1.728 Td (88.3 )Tj -1.337 -1.152 Td [(\()-4 (58 )]TJ -0.006 Tc 0.006 Tw (to )Tj 0 Tc 0 Tw 2.609 0 Td [(144)10.9 (\) )]TJ EMC /TD <>BDC 7.837 1.152 Td (1066 )Tj -1.718 -1.152 Td [(\()-4 (586 )11 (t)-4.6 (o 1754)10.9 (\) )]TJ EMC /Artifact <>BDC 12 0 0 12 321.0487 55.0303 Tm (21 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 31.0487 26.3903 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4635 0 obj <>>>/Resources 4525 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4636 0 obj <> endobj 4637 0 obj <>stream /
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 endstream endobj 4638 0 obj <> endobj 4639 0 obj <>stream q 1 0 0 1 20.928711 16.96875 cm 0 0 612 792 re W n /Artifact <>BDC q 1 0 0 1 -20.928711 -16.96875 cm BT /CS0 cs 0 scn /TT0 1 Tf 3 Tr 12 0 0 12 92.9287 55.6088 Tm ( )Tj 20 0 Td ( )Tj 19 0 Td ( )Tj -33.33 55.83 Td ( )Tj ET Q /CS0 cs 0 scn 72 706.68 68.04 0.6 re f q 1 0 0 1 -20.928711 -16.96875 cm BT /TT0 1 Tf 3 Tr 12 0 0 12 133.6087 705.5287 Tm ( )Tj 5.52 -1.66 Td ( )Tj -3.98 -2.33 Td ( )Tj 22.67 0 Td ( )Tj /TT1 1 Tf 0.001 Tc -0.001 Tw 1.92 0 Td ( )Tj 0 Tc 0 Tw -22.53 -1.17 Td ( )Tj 11.36 0 Td ( )Tj /TT0 1 Tf 3.31 0 Td ( )Tj /TT2 1 Tf 14.04 0 0 14.04 110.4506 615.8887 Tm ( )Tj 8.273 0 Td ( )Tj /TT0 1 Tf -0.004 Tc 0.004 Tw 12 0 0 12 143.0889 595.4887 Tm ( )Tj 8.25 0 Td ( )Tj 0 Tc 0 Tw 8.84 0 Td ( )Tj -16.58 -1.17 Td ( )Tj /TT2 1 Tf 14.04 0 0 14.04 110.4506 553.8487 Tm ( )Tj 8.333 0 Td ( )Tj /TT0 1 Tf 12 0 0 12 155.5687 533.4488 Tm ( )Tj 11.92 0 Td ( )Tj 8.76 0 Td ( )Tj 10.28 0 Td [( )-2250 ( )]TJ 1.24 -1.17 Td ( )Tj -0.004 Tc 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( )Tj -34.084 -2.438 Td ( )Tj ET Q EMC 1 0 0 1 -20.928711 -16.96875 cm BT /StyleSpan <>BDC /TT0 1 Tf 12 0 0 12 92.9287 725.5688 Tm [(C)-3 (ont)-2 (r)3 (a)4 (c)4 (e)4 (pt)-2 (i)-2 (on )]TJ EMC /P <>BDC /TT1 1 Tf -0.004 Tc 0 -1.67 TD [(F)-3 (em)-2 (a)-4 (l)-6 (es )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 -1.66 TD [(T)1 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (s )]TJ -0.004 Tc 0.004 Tw 9.16 0 Td [(ca)-10 (n)-4 ( cau)-4 (s)-5 (e em)-6 (b)-14 (r)-21 (y)16 (o)]TJ 0 Tc 0 Tw 7.16 0 Td [(-)3 (f)-7 (e)4 (t)-2 (a)4 (l)-2 ( ha)4 (r)-7 (m)-2 ( w)2 (he)4 (n a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d dur)-7 (i)-2 (ng)10 ( pr)3 (e)-6 (g)10 (n)-10 (a)4 (nc)-16 (y)20 (. )]TJ -16.32 -1.17 Td [(A)2 (dvi)-2 (s)-1 (e)4 ( f)3 (e)4 (m)-2 (a)4 (l)-2 (e)4 (s)-1 ( o)-10 (f)3 ( r)3 (e)4 (p)-10 (r)3 (od)-10 (uc)4 (t)-2 (i)-2 (ve)4 ( pot)-2 (e)4 (nt)-2 (i)-2 (a)4 (l)-2 ( t)-2 (o us)-1 (e)4 ( e)4 (f)3 (f)-7 (e)4 (c)4 (t)-2 (i)-2 (ve)4 ( c)4 (ont)-2 (r)-7 (a)4 (c)4 (e)4 (pt)-2 (i)-2 (on dur)3 (i)-12 (ng)10 ( t)-2 (r)3 (e)-6 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( w)2 (i)-2 (t)-2 (h )]TJ 0 -1.16 TD [(H)2 (E)1 (R)-3 (Z)11 (U)2 (M)-1 (A )-8 (a)4 (nd f)3 (or)3 ( 7 m)-12 (ont)-2 (hs)-1 ( f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng)10 ( t)-2 (he)4 ( l)-2 (a)4 (s)-1 (t)-2 ( d)-10 (os)-1 (e)4 ( of)3 ( H)2 (E)1 (R)-13 (Z)11 (U)2 (M)-1 (A )]TJ /TT1 1 Tf 0.001 Tc -0.001 Tw 27.85 0 Td [([se)-5 (e )]TJ -0.004 Tc 0.004 Tw 1.93 0 Td [(U)-2 (s)-5 (e i)-6 (n)-4 ( S)-4 (p)-4 (eci)-6 (f)-6 (i)-6 (c )]TJ 0 Tc 0 Tw -29.78 -1.17 Td [(P)1 (opul)-2 (at)-2 (i)-2 (ons)-1 ( \()13 (8.1)-10 (\) )13 (and C)-3 (l)-2 (i)-2 (ni)-2 (c)4 (al)-2 ( P)1 (har)-1 (m)2 (ac)4 (ol)-2 (ogy )-6 (\()13 (12.)-10 (3\))]TJ 0.041 Tc -0.041 Tw 20.99 0 Td (]. )Tj EMC /Span <>BDC /TT2 1 Tf -0.002 Tc 0 Tw 14.04 0 0 14.04 92.9287 615.8887 Tm [(8)-6.3 (.4 )]TJ EMC /Span <>BDC 0.004 Tc -0.006 Tw 3.846 0 Td [(P)8.2 (e)3.5 (d)4.4 (iat)12.2 (r)3.6 (ic)3.6 ( U)16.6 (se )]TJ EMC /P <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 12 0 0 12 92.9287 595.4887 Tm [(T)-3 (h)-4 (e s)-5 (af)-1 (et)-26 (y )6 (an)-4 (d)-4 ( ef)-11 (f)-1 (ect)-6 (i)-6 (v)-4 (en)-14.1 (es)-5 (s)-4.9 ( o)-4 (f )]TJ 0 Tc 0 Tw 12.68 0 Td [(t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (odu)-10 (c)4 (t)-2 (s )-0.9 (i)-2 (n pe)4 (di)-2 (a)4 (t)-2 (r)3 (i)-2 (c)4 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( h)-10 (a)4 (ve)4 ( not)-2 ( be)4 (e)4 (n )]TJ -0.004 Tc 0.004 Tw -12.68 -1.17 Td [(es)-5 (t)-6 (ab)-4 (l)-6 (i)-6 (s)-5 (h)-4 (ed)-4 (. )]TJ EMC /Span <>BDC /TT2 1 Tf -0.002 Tc 0 Tw 14.04 0 0 14.04 92.9287 553.8487 Tm [(8)-6.3 (.5 )]TJ EMC /Span <>BDC 0.001 Tc -0.003 Tw 3.846 0 Td [(G)1.2 (e)0.6 (r)0.5 (i)5.5 (a)-3.2 (t)0.7 (r)9.1 (i)-3.1 (c)0.6 ( U)5.1 (s)]TJ 0 Tc 0 Tw 5.299 0 Td (e )Tj EMC /P <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 12 0 0 12 92.9287 533.4488 Tm [(T)-3 (r)-1 (as)-5 (t)-6 (u)-4 (z)-10 (u)-4 (m)-6 (ab )]TJ 0 Tc 0 Tw 5.47 0 Td [(ha)4 (s)-1 ( be)4 (e)4 (n )-10 (a)4 (d)-10 (m)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d t)-2 (o 386 pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (ho w)2 (e)4 (r)3 (e)4 ( 65 )]TJ -0.003 Tc 0.003 Tw 20.7 0 Td [(y)17 (e)-9 (a)-9 (rs)-4 ( o)-3 (f a)-9 (g)6.9 (e)1 ( o)-13 (r o)-3 (v)-3 (e)1 (r )-10 (\(2)-3 (5)-3 (3 )]TJ 0 Tc 0 Tw 10.26 0 Td [(i)-2 (n t)-2 (he )]TJ 0.002 Tc -0.002 Tw -36.43 -1.17 Td [(a)6 (d)2 (ju)2 (v)2 (a)6 (n)2 (t tr)5 (e)6 (a)6 (tme)6 (n)2 (t a)6 (n)2 (d)2 ( 1)-8 (3)2 (3)2 ( in)2 ( me)6 (ta)6 (s)1 (ta)6 (tic)6 ( b)2 (r)5 (e)6 (a)6 (s)1 (t c)-3.9 (a)-4 (n)2 (c)5.9 (e)6.1 (r)5 ( tr)-5 (e)6.1 (a)5.9 (tme)6 (n)2 (t s)1 (e)6 (ttin)2 (g)12 (s)]TJ 0 Tc 0 Tw 29.07 0 Td [(\))3 (. )-10 (T)1 (he)4 ( r)3 (i)-2 (s)-1 (k of)3 ( c)-6 (a)4 (r)3 (di)-2 (a)4 (c )]TJ -0.004 Tc 0.004 Tw -29.07 -1.17 Td [(d)-14 (y)16 (s)-5 (f)-1 (u)-4 (n)-14 (ct)-6 (i)-6 (o)-4 (n)-4 ( w)-2 (as)-5 ( i)-6 (n)-4 (cr)-11 (eas)-4.9 (e)-10.1 (d)-4 ( i)-6 (n)-3.9 ( g)6 (er)-1 (i)-16 (at)-6 (r)-1 (i)-6 (c p)-4 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( as )-15 (co)-4 (m)-6 (p)-4 (ar)-1 (ed)-4 ( t)-6 (o )]TJ 0 Tc 0 Tw 25.08 0 Td [(y)20 (oun)-10 (g)10 (e)-6 (r)3 ( pa)4 (t)-12 (i)-2 (e)4 (nt)-2 (s)-1 ( i)-2 (n bot)-2 (h t)-2 (hos)-1 (e )]TJ -25.08 -1.16 Td [(r)3 (e)4 (c)4 (e)4 (i)-2 (vi)-2 (n)-10 (g)10 ( t)-2 (r)-7 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( f)3 (or)3 ( m)-12 (e)4 (t)-2 (a)4 (s)-1 (t)-2 (a)4 (t)-2 (i)-2 (c)4 ( di)-2 (s)-1 (e)4 (a)4 (s)-1 (e)4 ( i)-2 (n S)-4 (t)-2 (udi)-2 (e)4 (s)-1 ( 5 a)4 (nd 6, or)3 ( a)4 (dj)-2 (uv)-10 (a)4 (nt)-2 ( t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( i)-2 (n S)-4 (t)-2 (udi)-2 (e)4 (s)-1 ( 1 a)4 (nd )]TJ EMC /Span <>BDC 0 -1.17 TD (2. )Tj EMC /Span <>BDC 1.01 0 Td [(L)21 (i)-2 (m)-2 (i)-2 (t)-2 (a)4 (t)-2 (i)-2 (ons)-1 ( i)-2 (n da)4 (t)-2 (a)4 ( c)4 (ol)-12 (l)-2 (e)4 (c)4 (t)-2 (i)-2 (on a)4 (nd di)-2 (f)3 (f)3 (e)-6 (r)3 (e)4 (nc)-6 (e)4 (s)-1 ( i)-2 (n)-10 ( s)-1 (t)-2 (ud)-10 (y)20 ( de)4 (s)-1 (i)-12 (g)10 (n of)3 ( t)-2 (he)4 ( 4 s)-1 (t)-2 (u)-10 (di)-2 (e)4 (s)-1 ( of )]TJ 0.002 Tc -0.002 Tw 32.1 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw -33.11 -1.17 Td [(i)-2 (n a)4 (dj)-2 (uva)4 (nt)-2 ( t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( of )-7 (br)]TJ -0.004 Tc 0.004 Tw 10.66 0 Td [(eas)-5 (t)-6 ( c)-10 (an)-4 (ce)-10 (r)-1 ( p)-4 (r)-1 (e)-10 (cl)-6 (u)-4 (d)-4 (e a )-10 (d)-4 (et)-6 (er)-0.9 (m)-6.1 (i)-5.9 (n)-4 (at)-6 (i)-6 (o)-4 (n)-4 ( o)-4 (f)-1 ( w)-2 (h)-4 (et)-6 (h)-14 (er)-11 ( t)-6 (h)-4 (e t)-6 (o)-4 (x)-14 (i)-6 (ci)-6 (t)-16 (y)26 ( p)-4 (r)-1 (o)-4 (f)-1 (i)-6 (l)-6 (e o)-14 (f )]TJ 0 Tc 0 Tw -10.66 -1.16 Td [(t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b i)-2 (n ol)-2 (de)4 (r)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( i)-2 (s)-1 ( di)-2 (f)3 (f)3 (e)4 (r)3 (e)4 (nt)-2 ( f)-7 (r)3 (om )-12 (y)20 (ou)-10 (ng)10 (e)-6 (r)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 (. T)1 (he )-6 (r)3 (e)4 (por)3 (t)-12 (e)4 (d c)4 (l)-2 (i)-2 (ni)-2 (c)4 (a)4 (l)-2 ( e)4 (x)-10 (pe)4 (r)3 (i)-2 (e)4 (nc)-6 (e )]TJ T* [(i)-2 (s)-1 ( not)-2 ( a)4 (de)4 (qua)4 (t)-2 (e)4 ( t)-2 (o de)4 (t)-2 (e)-6 (r)3 (m)-2 (i)-2 (ne)4 ( w)2 (he)4 (t)-2 (he)4 (r)3 ( t)-2 (he )-6 (e)4 (f)3 (f)3 (i)-12 (c)4 (a)4 (c)-16 (y)20 ( i)-12 (m)-2 (pr)3 (ove)4 (m)-2 (e)4 (nt)-2 (s)-1 ( \()3 (O)2 (R)-3 (R)-3 (, T)1 (T)1 (P)-4 (, O)2 (S)-4 (, D)2 (F)6 (S)-4 (\))3 ( of )]TJ T* [(t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b )]TJ 0.002 Tc -0.002 Tw [(tr)5 (e)6 (a)6 (tme)6 (n)2 (t in)2 ( o)2 (ld)2 (e)6 (r)5 ( p)2 (a)6 (tie)6 (n)2 (ts)1 ( is)1 ( d)2 (if)5 (f)5 (e)6 (r)-5 (e)6 (n)2 (t)-10 ( f)5 (r)5 (o)2 (m th)1.9 (a)6.1 (t o)2.1 (b)2 (s)0.9 (e)6.1 (r)5 (v)2 (e)5.9 (d)2 ( in)2 ( p)-8 (a)-4 (tie)6 (n)2 (ts)1 ( <)6 ( 6)2 (5 )]TJ -0.003 Tc 0.003 Tw 34.74 0 Td [(y)17 (e)-9 (a)1 (rs)-4 ( o)-3 (f )]TJ -0.004 Tc 0.004 Tw -34.74 -1.17 Td [(ag)-4 (e f)-1 (o)-4 (r)-1 ( m)-16 (et)-6 (as)-5 (t)-6 (at)-6 (i)-6 (c d)-4 (i)-6 (s)-5 (eas)-15 (e an)-3.9 (d)-4 ( ad)-4 (j)-6 (u)-4 (v)-4 (an)-4 (t)-6 ( t)-6 (r)-11 (eat)-6 (m)-6 (en)-4 (t)-6 (. )]TJ EMC /P <>BDC /TT2 1 Tf 0.004 Tc 0 Tw 14.04 0 0 14.04 92.9287 367.7287 Tm (10 )Tj -0.004 Tc 0.004 Tw 3.846 0 Td [(O)-3.8 (VE)-3.7 (RDO)-3.8 (S)-3.5 (AG)-3.7 (E )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw 12 0 0 12 92.9287 347.3288 Tm [(T)1 (he)4 (r)3 (e)4 ( i)-2 (s)-1 ( no e)4 (x)-10 (pe)4 (r)3 (i)-2 (e)4 (n)-10 (c)4 (e)4 ( w)-8 (i)-2 (t)-2 (h ove)4 (r)3 (dos)-1 (a)-6 (g)10 (e)4 ( i)-2 (n hum)-2 (a)4 (n )-10 (c)4 (l)-2 (i)-2 (ni)-2 (c)4 (a)4 (l)-2 ( t)-2 (r)3 (i)-2 (a)4 (l)-2 (s)-1 (. S)-4 (i)-2 (ng)10 (l)-2 (e)4 ( dos)-11 (e)4 (s)-1 ( hi)-2 (g)10 (he)-6 (r)3 ( t)-2 (ha)4 (n )]TJ T* [(8 m)-2 (g)10 (/)-2 (k)-10 (g)10 ( ha)4 (ve)4 ( not)-2 ( b)-10 (e)4 (e)4 (n t)-2 (e)-6 (s)-1 (t)-2 (e)4 (d. )]TJ EMC /P <>BDC /TT2 1 Tf 0.004 Tc 14.04 0 0 14.04 92.9287 293.5688 Tm (11 )Tj -0.004 Tc 3.846 0 Td [(DE)-3.6 (S)-3.6 (CRI)-8.1 (PT)-3.6 (I)-8.2 (O)-3.8 (N )]TJ EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.012 Tw 12 0 0 12 92.9287 273.1687 Tm [(HE)-1 (R)-5 (Z)9 (UM)-3 (A \()1 (t)-4 (r)1 (a)2 (s)-3 (t)-4 (u)-2 (z)-8 (u)-2 (m)-4 (a)-8 (b)]TJ 0 Tc 0 Tw 10.42 0 Td [(-)3 (pkr)3 (b\))3 ( i)-2 (s)-1 ( a)4 ( hum)-2 (a)4 (ni)-2 (z)-6 (e)4 (d )-10 (I)3 (g)10 (G)2 (1 k)-10 (a)4 (ppa)4 ( m)-2 (onoc)4 (l)-2 (ona)4 (l )-12 (a)-6 (nt)-2 (i)-2 (bod)-10 (y)20 ( t)-2 (ha)4 (t )]TJ -10.42 -1.16 Td [(s)-1 (e)4 (l)-2 (e)4 (c)4 (t)-2 (i)-2 (ve)4 (l)-22 (y)20 ( bi)-2 (nds)-1 ( w)2 (i)-2 (t)-2 (h hi)-2 (g)10 (h a)-6 (f)3 (f)3 (i)-2 (ni)-2 (t)-12 (y)20 ( t)-2 (o t)-2 (he )-6 (e)4 (x)-10 (t)-2 (r)3 (a)4 (c)4 (e)4 (l)-12 (l)-2 (ul)-2 (a)4 (r)3 ( dom)-2 (a)4 (i)-2 (n of)3 ( t)-2 (he)4 ( hum)-2 (a)-6 (n e)4 (pi)-2 (de)4 (r)3 (m)-2 (a)4 (l )-12 (g)10 (r)3 (ow)2 (t)-2 (h )]TJ -0.004 Tc 0.004 Tw T* [(f)-1 (act)-6 (o)-4 (r)-1 ( r)-11 (ec)-10 (ep)-4 (t)-6 (o)-4 (r)-1 ( 2 )]TJ 0 Tc -0.01 Tw 11.52 0 0 11.52 175.1287 245.2087 Tm [(prot)-3.3 (e)-3.9 (i)-3.2 (n, H)3.2 (E)-3.6 (R2. )]TJ 0 Tw 6.333 0 Td [(T)-3.6 (ra)-3.9 (s)14 (t)-3.3 (uz)6.5 (um)-3.2 (a)-3.9 (b-)]TJ 12 0 0 12 312.0487 245.2087 Tm [(pkr)3 (b )]TJ 11.52 0 0 11.52 336.8887 245.2087 Tm [(i)-3.2 (s)3.5 ( produc)-3.9 (e)6.5 (d by)20.8 ( re)-3.9 (c)-3.9 (om)-3.3 (bi)-3.2 (na)6.4 (nt)-3.2 ( D)3.2 (N)3.3 (A)3.2 ( t)-3.2 (e)-3.9 (c)-3.9 (hno)10.4 (l)-3.3 (ogy)20.9 ( i)-3.3 (n )]TJ 0.004 Tc -0.004 Tw -21.177 -1.229 Td [(a m)0.7 (a)10.5 (m)0.8 (m)11.1 (al)11.2 (i)0.7 (an )14.4 (cel)11.2 (l)0.7 ( \()3.7 (C)4.3 (h)4 (i)11.2 (n)4 (es)18 (e H)7.3 (am)0.8 (s)7.6 (t)11.1 (er)3.7 ( O)7.2 (v)14.5 (ar)-6.7 (y)24.8 (\))3.7 ( cu)4 (l)0.7 (t)0.8 (u)3.9 (r)3.7 (e. )]TJ EMC /P <>BDC -0.002 Tc 0.012 Tw 12 0 0 12 92.9287 211.2487 Tm [(HE)-1 (R)-5 (Z)9 (UM)-3 (A \()1 (t)-4 (r)1 (a)2 (s)-3 (t)-4 (u)-2 (z)-8 (u)-2 (m)-4 (a)-8 (b)]TJ 0 Tc 0 Tw 10.42 0 Td [(-)3 (pkr)3 (b)]TJ -0.003 Tc 0.003 Tw (\) )Tj 0 Tc 0 Tw 11.52 0 0 11.52 250.8487 211.2487 Tm [(i)-3.2 (s)3.5 ( a)-3.9 ( s)3.6 (t)-3.2 (e)-4 (ri)-3.2 (l)7.1 (e)-3.9 (, w)3.3 (hi)-3.3 (t)7.2 (e )6.5 (t)-3.3 (o pa)-3.9 (l)7.2 (e)-3.9 ( y)20.8 (e)-3.9 (l)-3.3 (l)-3.2 (ow)3.2 (, pre)-3.9 (s)3.6 (e)-4 (rv)10.4 (a)-3.9 (t)-3.3 (i)-3.2 (v)10.4 (e)-5.3 (-f)10.1 (re)-3.9 (e)-3.9 ( l)-3.3 (y)20.9 (ophi)-3.3 (l)-3.2 (i)-3.3 (z)6.5 (e)-3.9 (d )]TJ -13.708 -1.229 Td [(pow)3.2 (de)-3.9 (r f)10.1 (or i)-3.2 (nj)-3.3 (e)6.5 (c)-3.9 (t)-3.2 (i)-3.3 (o)10.4 (n, f)10.1 (or i)-3.2 (nt)-3.3 (ra)-3.9 (v)10.4 (e)-3.9 (nous)3.5 ( a)-3.9 (d)10.4 (m)-3.2 (i)-3.3 (ni)-3.2 (s)3.6 (t)-3.3 (r)10.1 (a)-3.9 (t)7.1 (i)-3.2 (on. )]TJ EMC /P <>BDC 0.003 Tc -0.013 Tw 0 -1.729 TD [(E)-0.6 (a)-0.9 (c)-0.9 (h)3 ( mu)3 (l)10.2 (tip)13.4 (le)]TJ 0 Tc 0 Tw 5.583 0 Td [(-dos)3.5 (e)6.5 ( v)10.5 (i)-3.3 (a)-3.9 (l)-3.2 ( of)10 ( H)3.3 (E)-3.6 (RZ)17.3 (U)-7.2 (M)3.6 (A)3.2 ( de)-3.9 (l)-3.2 (i)-3.3 (v)10.5 (e)-4 (rs)3.6 ( 420 m)-3.3 (g)10.4 ( t)-3.2 (ra)-3.9 (s)3.5 (t)-3.2 (uz)6.5 (um)-3.3 (a)-3.9 (b-)]TJ 12 0 0 12 414.4087 177.1687 Tm [(pkr)3 (b)]TJ /C2_0 1 Tf 11.52 0 0 11.52 436.3687 177.1687 Tm [<000F0003001B0016001C>10.4 <00030050>-3.2 <004A>10.4 <0003012E>3.1 <000F012E>]TJ /TT0 1 Tf 5.052 0 Td [(-t)-3.3 (re)-3.9 (ha)-4 (l)-3.2 (os)3.6 (e )]TJ -34.865 -1.219 Td [(di)-3.2 (hy)20.8 (dra)-3.9 (t)-3.2 (e)-3.9 (, 9.5 m)-3.3 (g L)16.7 (-hi)-3.3 (s)3.6 (t)-3.2 (i)-3.3 (di)-3.2 (ne)-4 ( H)3.3 (Cl)-3.2 (, 6.1)10.4 ( m)-3.3 (g)10.5 ( L)16.7 (-hi)-3.3 (s)3.6 (t)-3.2 (i)-3.3 (di)-3.2 (ne)-4 (, a)-3.9 (nd 1.7 )10.4 (m)-3.2 (g)10.4 ( pol)-3.2 (y)10.4 (s)3.6 (orba)-3.9 (t)-3.2 (e )6.5 (20. Re)-3.9 (c)-3.9 (ons)3.5 (t)7.2 (i)-3.3 (t)-3.2 (u)10.4 (t)-3.2 (i)-3.3 (on )]TJ 0.001 -1.219 Td [(w)3.2 (i)-3.2 (t)-3.2 (h 20 m)-3.3 (L)17.2 ( of)10.1 ( t)-3.2 (he)-3.9 ( a)-3.9 (ppropr)10.1 (i)-3.2 (a)-4 (t)7.2 (e)-3.9 ( di)7.1 (l)-3.2 (ue)-3.9 (n)10.4 (t)-3.2 ( \(BW)6.5 (F)3.9 (I)10 ( or S)-6.5 (W)6.5 (F)3.9 (I)10.1 (\) )-10.4 (y)10.4 (i)-3.3 (e)-3.9 (l)-3.2 (ds)3.6 ( a)-4 ( s)3.6 (ol)-3.2 (ut)-3.3 (i)7.2 (on c)-3.9 (on)10.4 (t)-3.3 (a)6.5 (i)-3.2 (ni)-3.3 (ng)10.4 ( 21 m)-3.2 (g)10.4 (/)-3.2 (m)-3.3 (L )]TJ 0 -1.208 TD [(t)-3.2 (ra)-3.9 (s)3.6 (t)-3.3 (uz)6.5 (um)7.2 (a)-3.9 (b-)]TJ 12 0 0 12 153.0487 135.1687 Tm [(pkr)3 (b )]TJ 11.52 0 0 11.52 178.0087 135.1687 Tm [(t)-3.2 (ha)6.5 (t)-3.3 ( de)6.5 (l)-3.2 (i)7.1 (v)10.4 (e)-3.9 (rs)3.6 ( 20 m)-13.7 (L)17.2 ( \(420 m)-3.2 (g)10.4 ( t)-3.3 (ra)-3.9 (s)3.6 (t)-3.3 (u)10.4 (z)6.5 (um)-3.2 (a)-3.9 (b-)]TJ 12 0 0 12 372.1687 135.1687 Tm [(pkr)3 (b\))]TJ 11.52 0 0 11.52 398.0887 135.1687 Tm [(, a)-3.9 (t)-3.3 ( a )6.5 (pH)3.3 ( of)10.1 ( a)-3.9 (pproxi)-3.2 (m)7.1 (a)-3.9 (t)7.2 (e)-3.9 (l)-3.3 (y)20.8 ( 6. )-10.4 (If )]TJ -26.49 -1.219 Td [(H)3.2 (E)-3.5 (RZ)17.3 (U)-7.2 (M)3.6 (A)3.2 ( i)-3.2 (s)3.5 ( re)-3.9 (c)-3.9 (ons)3.6 (t)-3.3 (i)-3.2 (t)-3.3 (u)10.4 (t)7.2 (e)-3.9 (d w)3.2 (i)-3.2 (t)-3.3 (h S)3.9 (W)6.6 (F)3.9 (I)10 ( w)3.3 (i)-3.2 (t)-3.3 (hout)-3.3 ( pre)6.5 (s)3.6 (e)-3.9 (rv)10.5 (a)-3.9 (t)-3.3 (i)-3.3 (v)10.5 (e)-3.9 (, t)-3.3 (he)-3.9 ( r)10.1 (e)-3.9 (c)-4 (ons)3.6 (t)7.2 (i)-3.3 (t)-3.2 (u)10.4 (t)-3.3 (e)6.6 (d s)3.5 (ol)-3.2 (ut)-3.3 (i)-3.2 (on )10.4 (i)-3.3 (s)3.6 ( c)-3.9 (ons)3.6 (i)-3.2 (d)10.4 (e)-4 (re)-3.9 (d )]TJ 0.003 Tc 0 -1.219 TD [(s)6.6 (in)3.1 (g)13.4 (le)]TJ 0 Tc 2.385 0 Td [(-dos)3.5 (e)-3.9 (. )]TJ EMC /Artifact <>BDC 12 0 0 12 320.9287 55.6088 Tm (20)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 30.9287 26.9688 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4640 0 obj <>>>/Resources 4524 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4641 0 obj <> endobj 4642 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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5.48 0 Td ( )Tj -16.55 -1.16 Td [( )-4890 ( )]TJ 7.05 -1.17 Td ( )Tj 8.34 0 Td ( )Tj -17.9 -1.17 Td ( )Tj /TT1 1 Tf 14.04 0 0 14.04 110.6066 153.7687 Tm ( )Tj 21.906 0 Td ( )Tj /TT0 1 Tf 12 0 0 12 182.7247 133.3687 Tm ( )Tj ET Q 72 114.48 89.64 0.6 re f q 1 0 0 1 -21.084686 -16.96875 cm BT /TT0 1 Tf 0.002 Tc -0.002 Tw 3 Tr 12 0 0 12 516.0844 113.4488 Tm ( )Tj 0 Tc 0 Tw -30.06 -1.17 Td ( )Tj ET Q EMC 1 0 0 1 -21.084686 -16.96875 cm BT /StyleSpan <>BDC /TT0 1 Tf -0.004 Tc 12 0 0 12 93.0847 725.5688 Tm [(D)-2 (at)-6 (a )]TJ EMC /P <>BDC /TT2 1 Tf 0 Tc 0 -1.67 TD [(H)2 (um)2 (an D)2 (at)-2 (a )]TJ EMC /P <>BDC /TT0 1 Tf 0 -1.66 TD [(I)13 (n pos)-1 (t)-2 (-)3 (m)-12 (a)4 (r)3 (ke)4 (t)-2 (i)-2 (n)-10 (g)10 ( r)3 (e)4 (po)-10 (r)3 (t)-2 (s)-1 (, us)-1 (e)4 ( of )3 (t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b dur)3 (i)-2 (ng)10 ( pr)-7 (e)-6 (g)10 (na)4 (nc)-16 (y )10 (r)3 (e)4 (s)-1 (ul)-2 (t)-2 (e)4 (d i)-2 (n )-10 (c)4 (a)4 (s)-1 (e)4 (s)-1 ( of )]TJ 0 -1.17 TD [(ol)-2 (i)-2 (g)10 (oh)-20 (y)20 (dr)3 (a)4 (m)-2 (ni)-2 (os)-1 ( a)4 (nd of )-7 (ol)-2 (i)-2 (g)10 (oh)-20 (y)20 (dr)3 (a)4 (m)-2 (ni)-2 (os)-1 ( s)-1 (e)4 (que)4 (n)-10 (c)4 (e)4 (, m)-2 (a)4 (ni)-2 (f)3 (e)4 (s)-1 (t)-2 (i)-2 (n)-10 (g)10 ( i)-2 (n t)-2 (he)4 ( f)-7 (e)4 (t)-2 (us)-1 ( a)4 (s)-1 ( pul)-2 (m)-2 (ona)4 (r)-17 (y )]TJ -0.004 Tc 0.004 Tw 0 -1.16 TD [(h)-14 (y)16 (p)-4 (o)-4 (p)-4 (l)-6 (as)-5 (i)-6 (a,)-4 ( s)-5 (k)-14 (el)-6 (et)-6 (al)-6 ( ab)-3.9 (n)-4 (o)-14 (r)-1 (m)-6.1 (al)-6 (i)-6 (t)-6 (i)-6 (es)-5 (,)-4 ( an)-4 (d)-4 ( n)-4 (eo)-4 (n)-4 (at)-6 (al)-6 ( d)-14 (eat)-6 (h)-4 (.)-4 ( T)-3 (h)-4 (es)-5 (e )-10 (cas)-5 (e )-10 (r)-1 (ep)-4 (o)-4 (r)-1 (t)-6 (s )-14.9 (d)-4 (es)-5.1 (cr)-0.9 (i)-6 (b)-4 (ed )]TJ 0 Tc 0 Tw 0 -1.17 TD [(ol)-2 (i)-2 (g)10 (oh)-20 (y)20 (dr)3 (a)4 (m)-2 (ni)-2 (os)-1 ( i)-2 (n pr)3 (e)-6 (gna)4 (nt)-2 ( w)2 (om)-2 (e)4 (n w)2 (ho r)-7 (e)4 (c)4 (e)4 (i)-2 (ve)-6 (d t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b e)4 (i)-2 (t)-2 (he)4 (r)3 ( a)4 (l)-2 (on)-10 (e)4 ( or)3 ( i)-2 (n c)4 (om)-2 (bi)-2 (na)4 (t)-2 (i)-2 (on )]TJ T* [(w)2 (i)-2 (t)-2 (h c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 (. )-20 (I)13 (n s)-1 (om)-2 (e)4 ( c)4 (a)4 (s)-1 (e )-6 (r)3 (e)4 (por)3 (t)-2 (s)-1 (, a)4 (m)-2 (ni)-2 (ot)-2 (i)-2 (c)-6 ( f)3 (l)-2 (ui)-2 (d i)-2 (nde)4 (x)-10 ( i)-2 (nc)4 (r)3 (e)4 (a)4 (s)-1 (e)4 (d a)4 (f)3 (t)-12 (e)4 (r )3 (t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b )]TJ -0.004 Tc 0.004 Tw [(w)-2 (as )]TJ 0 Tc 0 Tw 0 -1.16 TD [(s)-1 (t)-2 (oppe)4 (d. )-10 (I)23 (n on)-10 (e)4 ( c)-6 (a)4 (s)-1 (e)4 (, t)-2 (r)3 (a)4 (s)-11 (t)-2 (uz)-6 (um)-2 (a)4 (b t)-2 (he)4 (r)3 (a)4 (p)-10 (y )10 (r)3 (e)4 (s)-1 (um)-2 (e)-6 (d a)4 (f)3 (t)-2 (e)4 (r )-7 (a)4 (m)-2 (ni)-2 (ot)-2 (i)-2 (c)4 ( i)-2 (nde)4 (x)-10 ( i)-2 (m)8 (pr)3 (ove)4 (d a)4 (nd )]TJ 0 -1.17 TD [(ol)-2 (i)-2 (g)10 (oh)-20 (y)20 (dr)3 (a)4 (m)-2 (ni)-2 (os)-1 ( r)3 (e)-6 (c)4 (ur)3 (r)-7 (e)-6 (d. )]TJ EMC /P <>BDC /TT2 1 Tf 0 -1.67 TD [(A)1 (ni)-2 (m)2 (al)-2 ( D)2 (at)-2 (a )]TJ EMC /P <>BDC /TT0 1 Tf 0 -1.66 TD [(I)13 (n s)-1 (t)-2 (udi)-2 (e)4 (s)-1 ( w)2 (h)-10 (e)4 (r)3 (e)4 ( t)-12 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b w)2 (a)4 (s)-1 ( a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d t)-2 (o )-10 (pr)3 (e)-6 (g)10 (na)4 (nt )-2 (C)-23 (y)20 (nom)-2 (ol)-2 (g)10 (us)-1 ( m)-12 (onke)-6 (y)20 (s)-1 ( du)-10 (r)3 (i)-2 (ng)10 ( t)-2 (h)-10 (e )]TJ 0 -1.17 TD [(pe)4 (r)3 (i)-2 (od of)3 ( or)-7 (g)10 (a)-6 (no)-10 (g)10 (e)4 (ne)4 (s)-1 (i)-2 (s )-11 (a)4 (t)-2 ( dos)-1 (e)4 (s)-1 ( up t)-2 (o 25 m)-2 (g)10 (/)-2 (k)-10 (g g)10 (i)-2 (ve)4 (n t)-2 (w)2 (i)-2 (c)-6 (e)4 ( w)2 (e)-6 (e)4 (kl)-22 (y)20 ( \()3 (up t)-12 (o 25 t)-2 (i)-2 (m)-2 (e)4 (s)-1 ( t)-2 (he )]TJ T* [(r)3 (e)4 (c)4 (om)-2 (m)-2 (e)4 (nde)4 (d )-10 (w)2 (e)4 (e)4 (kl)-22 (y)20 ( hu)-10 (m)-2 (a)4 (n dos)-1 (e)4 ( of)3 ( 2 m)-12 (g)10 (/)-2 (kg\))3 (, t)-2 (r)-7 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b c)4 (r)3 (os)-1 (s)-1 (e)4 (d t)-2 (he)4 ( pl)-12 (a)4 (c)4 (e)4 (nt)-2 (a)4 (l )]TJ -0.003 Tc 0.003 Tw 33.04 0 Td [(b)-13 (a)1 (rri)-5 (e)-9 (r d)-3.1 (u)-2.9 (ri)-5 (n)-13 (g )]TJ 0 Tc 0 Tw -33.04 -1.16 Td [(t)-2 (he)4 ( e)4 (a)4 (r)3 (l)-22 (y)20 ( \()-7 (G)2 (e)4 (s)-1 (t)-2 (a)4 (t)-2 (i)-2 (on D)2 (a)-16 (y)20 (s)-11 ( 20 t)-2 (o 50\))3 ( a)4 (nd l)-2 (a)4 (t)-2 (e)4 ( \()3 (G)-8 (e)4 (s)-1 (t)-2 (a)-6 (t)-2 (i)-2 (on D)2 (a)-6 (y)20 (s)-1 ( 120 t)-2 (o 150\))3 ( ph)-10 (a)4 (s)-1 (e)4 (s)-1 ( of )-7 (g)10 (e)4 (s)-1 (t)-2 (a)4 (t)-2 (i)-2 (on. T)1 (he )]TJ 0.002 Tc -0.002 Tw T* [(r)5 (e)6 (s)1 (u)2 (ltin)2 (g)12 ( c)6 (o)2 (n)-8 (c)6 (e)6 (n)2 (tr)-5 (a)6 (tio)2 (n)2 (s)1 ( o)2 (f)5 ( tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b)2 ( in)2 ( f)5 (e)6 (ta)5.9 (l s)1.1 (e)-4.1 (r)5.1 (u)2 (m a)6.1 (n)2 (d)1.9 ( a)6 (mn)2 (io)2 (tic)6 ( f)5 (lu)2 (id)2 ( w)-6 (e)6 (r)5 (e)6 ( a)6 (p)2 (p)-8 (r)5 (o)2 (x)-8 (ima)6 (te)6 (l)-10 (y )]TJ 0 Tc 0 Tw T* [(33%)3 ( a)4 (nd 25%)3 (, r)-7 (e)4 (s)-1 (pe)4 (c)4 (t)-2 (i)-2 (ve)-6 (l)-12 (y)20 (, of)3 ( t)-2 (hos)-1 (e)4 ( p)-10 (r)3 (e)4 (s)-1 (e)4 (nt)-2 ( i)-2 (n t)-2 (he )]TJ 0.002 Tc -0.002 Tw 20.52 0 Td [(ma)6 (te)6 (r)5 (n)2 (a)6 (l s)1 (e)6 (r)5 (u)2 (m b)2 (u)2 (t w)-6 (e)6 (r)5 (e)-4 ( n)2 (o)2 (t a)6 (s)1 (s)1 (o)2 (c)6 (ia)6 (te)6 (d)2 ( w)4 (ith )]TJ -0.004 Tc 0.004 Tw -20.52 -1.17 Td [(ad)-4 (v)-4 (er)-1 (s)-5 (e d)-14 (ev)-4 (el)-6 (o)-4 (p)-4 (m)-6 (en)-4 (t)-6 (al )-16 (ef)-11 (f)-1 (ect)-5.9 (s)-5 (. )]TJ EMC /Span <>BDC /TT1 1 Tf -0.002 Tc 0 Tw 14.04 0 0 14.04 93.0847 449.9288 Tm [(8)-6.3 (.2 )]TJ EMC /Span <>BDC 0.004 Tc 3.846 0 Td [(L)4.3 (ac)3.5 (t)12.2 (at)12.2 (ion )]TJ EMC /StyleSpan <>BDC /TT0 1 Tf 0.002 Tc -0.002 Tw 12 0 0 12 93.0847 429.5287 Tm [(R)-1 (is)1 (k)2 ( S)-2 (u)2 (mma)6 (r)-5 (y )]TJ EMC /P <>BDC 0 Tc 0 Tw 0 -1.67 TD [(T)1 (he)4 (r)3 (e)4 ( i)-2 (s)-1 ( no i)-2 (nf)3 (or)3 (m)-2 (a)4 (t)-2 (i)-2 (on r)-7 (e)4 (ga)4 (r)3 (di)-2 (n)-10 (g)10 ( t)-2 (he)4 ( pr)-7 (e)4 (s)-1 (e)4 (nc)-6 (e)4 ( of )-7 (t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (s)-1 ( i)-2 (n hum)-2 (a)4 (n m)-2 (i)-2 (l)-2 (k, t)-2 (he )]TJ 0 -1.16 TD [(e)4 (f)3 (f)3 (e)-6 (c)4 (t)-2 (s)-1 ( on t)-2 (he)4 ( br)3 (e)-6 (a)4 (s)-1 (t)-2 (f)3 (e)4 (d i)-12 (nf)3 (a)4 (nt)-2 (, or)3 ( t)-2 (he)4 ( e)-6 (f)3 (f)3 (e)-6 (c)4 (t)-2 (s)-1 ( on m)-2 (i)-2 (l)-2 (k pr)3 (oduc)4 (t)-2 (i)-2 (on. P)-4 (ubl)-2 (i)-2 (s)-1 (he)4 (d)10 ( da)4 (t)-2 (a)4 ( s)-1 (ugge)4 (s)-1 (t)-2 ( hum)-2 (a)4 (n )]TJ 0 -1.17 TD [(I)13 (gG)-8 ( i)-2 (s)-1 ( pr)3 (e)4 (s)-1 (e)4 (nt)-2 ( i)-2 (n hum)-2 (a)4 (n )-10 (m)-2 (i)-2 (l)-2 (k but)-2 ( doe)4 (s)-1 ( not)-2 ( e)4 (nt)-2 (e)4 (r)3 ( t)-2 (he)4 ( ne)4 (ona)4 (t)-2 (a)4 (l )-12 (a)4 (nd i)-2 (nf)3 (a)4 (nt)-2 ( c)4 (i)-2 (r)-7 (c)4 (ul)-2 (a)4 (t)-2 (i)-2 (on i)-2 (n s)-1 (ubs)-1 (t)-2 (a)4 (nt)-2 (i)-2 (a)4 (l )]TJ T* [(a)4 (m)-2 (ount)-2 (s)-1 (. T)1 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b w)2 (a)4 (s)-1 ( pr)3 (e)4 (s)-1 (e)4 (nt)-2 ( i)-2 (n t)-2 (he)4 ( m)-2 (i)-2 (l)-2 (k of)3 ( l)-12 (a)4 (c)4 (t)-2 (a)4 (t)-2 (i)-2 (n)-10 (g)10 ( C)-13 (y)20 (nom)-2 (ol)-12 (g)10 (us)-1 ( m)-2 (o)-10 (nke)-6 (y)20 (s)-1 ( but)-2 ( not )]TJ 0.002 Tc -0.002 Tw 0 -1.16 TD [(a)6 (s)1 (s)1 (o)2 (c)6 (ia)6 (te)6 (d)2 ( w)4 (ith)2 ( n)2 (e)6 (o)2 (n)-8 (a)6 (ta)6 (l )-10 (to)2 (x)-8 (ic)6 (it)-10 (y )]TJ /TT2 1 Tf 0.001 Tc -0.001 Tw 13.33 0 Td [([se)5 (e )]TJ -0.002 Tc 0.002 Tw 1.91 0 Td [(Da)-2 (t)-4 (a)]TJ 0 Tc 0 Tw 1.98 0 Td [(])-41 (. )]TJ /TT0 1 Tf [(C)-3 (ons)9 (i)-2 (de)4 (r)3 ( t)-2 (he)4 ( de)4 (ve)4 (l)-2 (opm)-2 (e)4 (nt)-12 (a)4 (l)-2 ( a)-6 (nd he)4 (a)4 (l)-2 (t)-2 (h be)4 (ne)4 (f)3 (i)-2 (t)-2 (s)-1 ( of )]TJ 0.002 Tc -0.002 Tw -17.22 -1.17 Td [(b)2 (r)5 (e)6 (a)6 (s)1 (tf)5 (e)-4 (e)6 (d)2 (in)-8 (g)12 ( a)6 (lo)2 (n)-8 (g)12 ( w)4 (ith )-8 (th)2 (e)6 ( mo)2 (th)2 (e)6 (r)5 (')12 (s )-9 (c)6 (lin)2 (ic)6 (a)6 (l n)2 (e)5.9 (e)6.1 (d)-8.1 ( f)4.9 (o)2 (r)5.1 ( H)4 (E)3.1 (R)-11.1 (Z)13 (U)4 (M)1 (A)4 ( tr)-5 (e)6 (a)6 (tme)-4 (n)2 (t a)6 (n)2 (d)2 ( a)6 (n)-18 (y)22 ( p)2 (o)2 (te)6 (n)2 (tia)6 (l )]TJ -0.004 Tc 0.004 Tw 0 -1.17 TD [(ad)-4 (v)-4 (er)-1 (s)-5 (e )-10 (ef)-1 (f)-11 (ect)-6 (s)-5 ( o)-4 (n)-4 ( t)-6 (h)-4 (e b)-4 (r)-10.9 (e)-10.1 (as)-5 (t)-6 (f)-0.9 (ed)-4 ( ch)-4 (i)-6 (l)-6 (d)-4 ( f)-1 (r)-1 (o)-4 (m)-6 ( H)-2 (E)-3 (R)-17 (Z)-3 (U)-2 (M)-5 (A)-2 ( o)-4 (r)-1 ( f)-1 (r)-1 (o)-4 (m)-6 ( t)-6 (h)-4 (e u)-4 (n)-4 (d)-14 (er)-1 (l)-16 (y)16 (i)-16 (n)-14 (g)6 ( m)-6 (at)-5.9 (er)-1.1 (n)-14 (al )]TJ 0 Tc 0 Tw 0 -1.16 TD [(c)4 (ondi)-2 (t)-2 (i)-2 (on. T)1 (hi)-2 (s)-1 ( c)4 (ons)-1 (i)-2 (de)4 (r)3 (a)-6 (t)-2 (i)-2 (on s)-1 (houl)-2 (d a)4 (l)-2 (s)-1 (o t)-2 (a)4 (ke)4 ( i)-2 (nt)-2 (o a)4 (c)4 (c)4 (ount)-2 ( t)-2 (he)4 ( t)-2 (r)-7 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 ( w)2 (a)4 (s)-1 (h out )]TJ 0 -1.17 TD [(pe)4 (r)3 (i)-2 (od of)3 ( 7 m)-2 (ont)-2 (hs )]TJ /TT2 1 Tf -0.004 Tc 0.004 Tw 7.83 0 Td [([)-5 (s)-5 (ee )]TJ 0 Tc 0 Tw 1.92 0 Td [(C)-3 (l)-2 (i)-2 (ni)-2 (c)4 (al)-2 ( P)1 (har)-1 (m)2 (ac)4 (ol)-2 (ogy)4 ( \()3 (12.3\))]TJ 0.041 Tc -0.041 Tw 11.99 0 Td (]. )Tj EMC /StyleSpan <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw -21.74 -2.17 Td [(D)-2 (at)-6 (a )]TJ EMC /P <>BDC 0 Tc 0 Tw 0 -1.66 TD [(I)13 (n l)-2 (a)-6 (c)4 (t)-2 (a)4 (t)-2 (i)-2 (n)-10 (g)10 ( C)-13 (y)20 (nom)-2 (ol)-12 (g)10 (us )-11 (m)-2 (onke)-6 (y)20 (s)-1 (, t)-2 (r)-7 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b w)2 (a)4 (s)-1 ( pr)3 (e)4 (s)-1 (e)4 (nt)-2 ( i)-2 (n br)-7 (e)4 (a)4 (s)-1 (t)-2 ( m)-2 (i)-2 (l)-2 (k a)4 (t)-2 ( a)4 (bout)-2 ( 0.3%)3 ( of )]TJ -0.004 Tc 0.004 Tw 0 -1.17 TD [(m)-6 (at)-6 (er)-1 (n)-4 (al)-6 ( s)-5 (er)]TJ 0 Tc 0 Tw 4.9 0 Td [(um )-12 (c)4 (onc)4 (e)4 (nt)-12 (r)-7 (a)4 (t)-2 (i)-2 (ons)-1 ( a)4 (f)3 (t)-2 (e)4 (r)3 ( pr)-7 (e)4 (-)-247 (\()3 (b)-10 (e)-6 (g)10 (i)-2 (nni)-2 (ng)10 ( G)-8 (e)4 (s)-1 (t)-2 (a)4 (t)-2 (i)-2 (on D)2 (a)-16 (y)20 ( 120\) )-7 (a)-6 (nd pos)-1 (t)-2 (-)3 (pa)4 (r)3 (t)-2 (um )]TJ -4.9 -1.17 Td [(\()3 (t)-2 (hr)3 (oug)10 (h P)-4 (os)-1 (t)-2 (-)3 (pa)-6 (r)3 (t)-2 (um)-2 ( D)2 (a)-6 (y )10 (28\))3 ( dos)-11 (e)4 (s)-1 ( of)3 ( 25 m)-12 (g)10 (/)-2 (kg a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d t)-2 (w)2 (i)-2 (c)4 (e)4 ( w)-8 (e)4 (e)4 (kl)-12 (y )10 (\()3 (25 t)-2 (i)-2 (m)-2 (e)4 (s)-1 ( t)-2 (he )]TJ 0 -1.16 TD [(r)3 (e)4 (c)4 (om)-2 (m)-2 (e)4 (nde)4 (d )-10 (w)2 (e)4 (e)4 (kl)-22 (y)20 ( hu)-10 (m)-2 (a)4 (n dos)-1 (e)4 ( of)3 ( 2 m)-12 (g)10 (/)-2 (kg)10 ( o)-10 (f )]TJ 0.002 Tc -0.002 Tw 19.82 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(pr)3 (oduc)4 (t)-2 (s)-1 (\))3 (. )-10 (I)13 (n)-10 (f)3 (a)4 (nt)-2 ( m)-2 (onke)-16 (y)20 (s)-1 ( w)2 (i)-2 (t)-2 (h )]TJ -0.004 Tc 0.004 Tw -24.96 -1.17 Td [(d)-4 (et)-6 (ect)-6 (a)]TJ 0 Tc 0 Tw [(bl)-2 (e)4 ( s)-11 (e)4 (r)3 (um)-2 ( l)-2 (e)4 (ve)4 (l)-2 (s)-1 ( o)-10 (f)3 ( t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b di)-2 (d not)-2 ( e)4 (x)-10 (h)10 (i)-2 (bi)-2 (t)-2 ( a)4 (n)-10 (y)20 ( a)4 (dv)-10 (e)4 (r)3 (s)-1 (e )-6 (e)4 (f)3 (f)-7 (e)4 (c)4 (t)-2 (s)-1 ( o)-10 (n g)10 (r)3 (o)-10 (w)2 (t)-2 (h or )]TJ 0 -1.17 TD [(de)4 (ve)4 (l)-2 (opm)-2 (e)4 (nt)-2 ( f)3 (r)3 (om)-2 ( bi)-2 (r)3 (t)-2 (h t)-12 (o 1 m)-2 (ont)-2 (h of)3 ( a)4 (ge)4 (. )]TJ EMC /Span <>BDC /TT1 1 Tf -0.002 Tc 14.04 0 0 14.04 93.0847 153.7687 Tm [(8)-6.3 (.3 )]TJ EMC /Span <>BDC 0.004 Tc -0.006 Tw 3.846 0 Td [(F)8.2 (e)3.5 (m)16.5 (ale)3.5 (s an)13 (d)4.4 ( M)7.8 (al)8.5 (e)3.6 (s )8.7 (of)3.7 ( R)8.1 (e)3.5 (p)4.5 (r)12.1 (od)4.4 (u)4.5 (c)3.5 (t)12.3 (iv)8.3 (e)3.5 ( P)8.1 (ot)12.3 (e)3.5 (n)4.5 (t)3.6 (i)8.5 (al )]TJ EMC /StyleSpan <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 12 0 0 12 93.0847 133.3687 Tm [(P)-8 (r)-1 (eg)6 (n)-14 (an)-4 (c)-20 (y)16 ( T)-13 (es)-5 (t)-6 (i)-6 (n)-4 (g )]TJ EMC /P <>BDC 0 Tc 0 Tw 0 -1.66 TD [(V)2 (e)4 (r)3 (i)-2 (f)-17 (y)20 ( t)-2 (he)4 ( pr)-7 (e)-6 (g)10 (na)4 (n)-10 (c)-16 (y)20 ( s)-1 (t)-2 (a)4 (t)-12 (us)-1 ( of)3 ( f)3 (e)4 (m)-2 (a)4 (l)-2 (e)4 (s)-1 ( o)-10 (f)3 ( r)3 (e)4 (p)-10 (r)3 (oduc)-6 (t)-2 (i)-2 (ve)4 ( pot)-2 (e)4 (nt)-2 (i)-2 (a)4 (l)-2 ( pr)]TJ 0.002 Tc -0.002 Tw 26.69 0 Td [(io)2 (r)5 ( to)2 ( th)2 (e)6 ( in)2 (itia)6 (tio)2 (n)2 ( o)2 (f )]TJ -0.002 Tc 0 Tw -26.69 -1.17 Td [(HE)-1 (R)-5 (Z)9 (UM)-3 (A. )]TJ EMC /Artifact <>BDC 0 Tc 19 -3.65 Td (19)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 31.0847 26.9688 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4645 0 obj <>>>/Resources 4523 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4646 0 obj <> endobj 4647 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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( )Tj /TT0 1 Tf 12 0 0 12 262.5489 504.1903 Tm ( )Tj 5.78 0 Td ( )Tj 10.79 0 Td [( )-950 ( )]TJ 6.94 -1.17 Td ( )Tj -0.004 Tc 0.004 Tw -34.2 -1.16 Td ( )Tj /TT3 1 Tf 0.001 Tc -0.001 Tw 1.92 0 Td ( )Tj 0 Tc 0 Tw 9.61 0 Td ( )Tj /TT0 1 Tf -0.023 Tc 0.033 Tw 4.22 0 Td ( )Tj 0 Tc 0 Tw -7.73 -1.17 Td ( )Tj 23.42 0 Td ( )Tj -0.004 Tc 0.004 Tw -20.06 -1.17 Td ( )Tj 0 Tc 0 Tw 19.25 0 Td ( )Tj /TT1 1 Tf 14.04 0 0 14.04 102.7127 408.4303 Tm ( )Tj 19.009 0 Td ( )Tj -18.256 -2 Td ( )Tj 7.136 0 Td ( )Tj /TT0 1 Tf 12 0 0 12 167.3889 359.9503 Tm ( )Tj ET Q /CS0 cs 0 scn 72 341.64 71.64 0.6 re f q 1 0 0 1 -23.748901 -16.390259 cm BT /TT0 1 Tf 3 Tr 12 0 0 12 202.6689 340.0303 Tm ( )Tj -4.87 -1.17 Td ( )Tj 5.96 0 Td ( )Tj 27.33 0 Td ( )Tj -17.57 -1.17 Td ( )Tj -0.004 Tc 0.004 Tw -12.27 -1.16 Td ( )Tj 0 Tc 0 Tw 29.32 0 Td ( )Tj 0.002 Tc -0.002 Tw -26.99 -1.17 Td [( )-450 ( )]TJ 0 Tc 0 Tw 9.14 0 Td ( )Tj 17.27 0 Td ( )Tj -2.69 -1.17 Td ( )Tj -26.79 -1.17 Td ( )Tj -0.004 Tc 0.004 Tw 27.9 -1.66 Td ( )Tj 0 Tc 0 Tw 3.25 -1.17 Td ( )Tj -31.25 -1.16 Td ( )Tj -1.57 -1.17 Td ( )Tj 4.34 -2.17 Td ( )Tj ET Q 72 149.64 113.04 0.599 re f q 1 0 0 1 -23.748901 -16.390259 cm BT /TT3 1 Tf 3 Tr 12 0 0 12 209.9889 147.9103 Tm ( )Tj /TT0 1 Tf 4.2 0 Td ( )Tj 21.48 -2.83 Td ( )Tj -0.004 Tc 0.014 Tw -24.65 -1.17 Td ( )Tj 0 Tc 0 Tw 21.69 0 Td ( )Tj ET Q EMC 1 0 0 1 -23.748901 -16.390259 cm BT /Span <>BDC /TT1 1 Tf -0.002 Tc 14.04 0 0 14.04 95.7489 723.3103 Tm [(6)-6.3 (.3 )]TJ EMC /Span <>BDC 0.004 Tc -0.004 Tw 3.846 0 Td [(P)8.2 (ost)]TJ 0 Tc 0 Tw 1.838 0 Td (-)Tj 0.001 Tc -0.003 Tw [(M)13.3 (a)-3.2 (r)0.5 (k)18.6 (e)0.6 (t)0.6 (i)-3 (n)1.4 (g)-3.2 ( E)9.9 (x)-3.3 (p)10 (e)0.6 (r)0.5 (i)-3 (e)0.6 (n)10 (c)0.5 (e )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw 12 0 0 12 95.7489 702.9103 Tm [(T)1 (he)4 ( f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng a)4 (dve)4 (r)3 (s)-11 (e)4 ( r)3 (e)-6 (a)4 (c)4 (t)-2 (i)-2 (ons)-1 ( ha)4 (ve)4 ( be)-6 (e)4 (n i)-2 (de)4 (nt)-2 (i)-2 (f)-7 (i)-2 (e)4 (d dur)3 (i)-2 (ng)10 ( pos)-1 (t)-2 (-)-7 (a)4 (ppr)3 (ova)4 (l )-12 (us)-1 (e)4 ( of )]TJ 0.002 Tc -0.002 Tw 32.73 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b)]TJ 0 Tc 0 Tw 4.89 0 Td (. )Tj -37.62 -1.16 Td [(B)7 (e)4 (c)-6 (a)4 (us)-1 (e)4 ( t)-2 (he)4 (s)-11 (e)4 ( r)3 (e)-6 (a)4 (c)4 (t)-2 (i)-2 (ons)-1 ( a)-6 (r)3 (e)4 ( r)3 (e)4 (po)-10 (r)3 (t)-2 (e)4 (d vol)-2 (unt)-2 (a)4 (r)3 (i)-2 (l)-22 (y)20 ( f)3 (r)-7 (om)-2 ( a)4 ( popul)-2 (a)4 (t)-2 (i)-2 (on of)3 ( unc)4 (e)4 (r)-7 (t)-2 (a)4 (i)-2 (n s)-1 (i)-2 (z)-6 (e)4 (, i)-2 (t)-2 ( i)-2 (s)-1 ( not )]TJ 0 -1.17 TD [(a)4 (l)-2 (w)2 (a)-16 (y)20 (s)-1 ( pos)-1 (s)-1 (i)-2 (bl)-2 (e)4 ( t)-2 (o r)3 (e)4 (l)-2 (i)-2 (a)4 (bl)-12 (y )10 (e)4 (s)-1 (t)-2 (i)-2 (m)-2 (a)4 (t)-2 (e)4 ( t)-2 (he)4 (i)-12 (r)3 ( f)3 (r)-7 (e)4 (que)4 (nc)-6 (y )10 (or )-7 (e)4 (s)-1 (t)-2 (a)4 (bl)-2 (i)-2 (s)-1 (h a)4 ( c)4 (a)4 (us)-11 (a)4 (l)-2 ( r)3 (e)4 (l)-12 (a)4 (t)-2 (i)-2 (ons)-1 (hi)-2 (p t)-2 (o dr)3 (ug )]TJ T* [(e)4 (x)-10 (pos)-1 (ur)3 (e)4 (. )]TJ EMC /Lbl <>BDC /C2_0 1 Tf 3 -1.73 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf -0.013 Tc 0.013 Tw 1.5 0 Td [(In)-23 (f)-10 (u)]TJ 0 Tc 0 Tw 1.66 0 Td [(s)-1 (i)-2 (on r)3 (e)4 (a)-6 (c)4 (t)-2 (i)-2 (on )]TJ /TT3 1 Tf [([)-1 (s)-1 (e)4 (e )-6 (W)3 (ar)-1 (ni)-2 (ngs)-1 ( and P)1 (r)-1 (e)4 (c)4 (aut)-2 (i)-2 (on)]TJ 0.001 Tc -0.001 Tw (s \()Tj 0 Tc 0 Tw 18.6 0 Td (5.2)Tj -0.023 Tc 0.023 Tw 1.26 0 Td (\)] )Tj EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 0 Tw -23.02 -1.71 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(O)2 (l)-2 (i)-2 (g)10 (oh)-20 (y)20 (dr)-7 (a)4 (m)-2 (ni)-2 (os)-1 ( or)3 ( ol)-2 (i)-2 (goh)-10 (y)20 (dr)-7 (a)4 (m)-2 (ni)-2 (os)-1 ( s)-1 (e)4 (que)4 (nc)-6 (e)4 (, i)-2 (nc)4 (l)-2 (udi)-2 (ng)10 ( pul)-2 (m)-2 (ona)4 (r)-17 (y)20 ( h)-20 (y)20 (p)-10 (opl)-2 (a)4 (s)-1 (i)-2 (a)4 (, )]TJ -0.004 Tc 0.004 Tw T* [(s)-5 (k)-4 (el)-6 (et)-6 (al)-6 ( ab)-4 (n)-4 (o)-4 (r)-1 (m)-6 (al)-6 (i)-6 (t)-6 (i)-6 (es)-5 (,)-3.9 ( an)-14 (d)-4 ( n)-4 (eo)-4 (n)-4 (at)-6 (al)-6 ( d)-4 (e)-10 (at)-6 (h )]TJ /TT3 1 Tf 0 Tc 0 Tw 16.99 0 Td [([)-1 (s)-1 (e)4 (e )-6 (W)13 (a)-10 (r)-1 (ni)-2 (ngs)-1 ( and P)1 (r)-1 (e)4 (c)4 (aut)-2 (i)-2 (ons)-1 ( \()3 (5.3\))33 (] )]TJ EMC /Lbl <>BDC /C2_0 1 Tf -18.49 -1.73 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(G)2 (l)-2 (om)-2 (e)4 (r)3 (ul)-2 (opa)4 (t)-2 (h)-10 (y )]TJ /TT3 1 Tf -0.004 Tc 0.004 Tw 6.79 0 Td [([)-5 (s)-15 (ee A)-3 (d)-14 (ver)-5 (s)-5 (e R)-3 (ea)-14 (ct)-6 (i)-6 (o)-4 (n)-4 (s )-15 (\()]TJ 0 Tc 0 Tw 9.92 0 Td (6.1)Tj -0.033 Tc 0.033 Tw 1.26 0 Td (\)] )Tj EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 0 Tw -19.47 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(I)13 (m)-2 (m)-2 (une)4 ( t)-2 (hr)3 (om)-2 (bo)-10 (c)-16 (y)30 (t)-2 (op)-10 (e)4 (n)-10 (i)-2 (a )]TJ EMC /P <>BDC /TT1 1 Tf 14.04 0 0 14.04 95.7489 524.5903 Tm (7 )Tj -0.004 Tc 0.002 Tw 3.846 0 Td [(DRUG)-3.8 ( I)-8.1 (NT)-3.7 (E)-3.6 (RACT)-12.2 (I)-8.1 (O)-3.8 (NS )]TJ EMC /P <>BDC /TT0 1 Tf 0.004 Tw 12 0 0 12 95.7489 504.1903 Tm [(P)-8 (at)-6 (i)]TJ 0 Tc 0 Tw 1.56 0 Td [(e)4 (nt)-2 (s)-1 ( w)2 (ho r)3 (e)4 (c)4 (e)4 (i)-2 (v)-10 (e)4 ( a)4 (nt)-12 (hr)3 (a)4 (c)-16 (y)20 (c)4 (l)-2 (i)-2 (ne )-6 (a)4 (f)3 (t)-2 (e)-6 (r)3 ( s)-1 (t)-2 (oppi)-2 (ng t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (s)-1 ( m)-2 (a)4 (y )10 (be )-6 (a)4 (t)-2 ( i)-2 (nc)4 (r)3 (e)-6 (a)4 (s)-1 (e)4 (d r)3 (i)-2 (s)-1 (k )]TJ -1.56 -1.17 Td [(of)3 ( c)4 (a)4 (r)3 (di)-12 (a)4 (c)4 ( d)-20 (y)20 (s)-1 (f)3 (un)-10 (c)4 (t)-2 (i)-2 (on be)-6 (c)4 (a)4 (us)-1 (e)4 ( of)3 ( t)-2 (r)-7 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b')10 (s)-1 ( l)-2 (o)-10 (ng)10 ( w)-8 (a)4 (s)-1 (hout)-2 ( pe)4 (r)3 (i)-2 (od ba)4 (s)-11 (e)4 (d )-10 (on popul)-2 (a)4 (t)-2 (i)-2 (on P)-4 (K )]TJ -0.004 Tc 0 -1.16 TD [(an)-4 (al)-26 (y)26 (s)-5 (i)-6 (s )]TJ /TT3 1 Tf 0.001 Tc -0.001 Tw 3.46 0 Td [([se)-5 (e )]TJ 0 Tc 0 Tw 1.92 0 Td [(C)-3 (l)-1.9 (i)-2.1 (ni)-1.9 (c)3.9 (al)-1.9 ( P)0.9 (har)-0.9 (m)2 (ac)3.9 (ol)-2 (ogy )-5.9 (\()13 (12.3)-10 (\))32.9 (])]TJ /TT0 1 Tf -0.023 Tc 0.033 Tw 12.43 0 Td [(.)-23 ( If )]TJ 0 Tc 0 Tw 1.4 0 Td [(p)-10 (os)-1 (s)-1 (i)-2 (bl)-2 (e)4 (, ph)-10 (y)20 (s)-1 (i)-2 (c)4 (i)-2 (a)4 (ns)-1 ( s)-1 (houl)-12 (d a)4 (voi)-2 (d )]TJ -0.004 Tc 0.004 Tw -19.21 -1.17 Td [(an)-4 (t)-6 (h)-4 (r)-1 (ac)-20 (y)16 (cl)-6 (i)-6 (n)-14 (e)]TJ 0 Tc 0 Tw [(-)3 (ba)4 (s)-11 (e)4 (d t)-2 (he)4 (r)-7 (a)4 (p)-10 (y )10 (f)3 (or)3 ( up t)-2 (o 7 m)-2 (ont)-2 (hs)-1 ( a)4 (f)-7 (t)-2 (e)4 (r)3 ( s)-1 (t)-2 (oppi)-2 (ng)10 ( t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b )-10 (pr)3 (oduc)4 (t)-2 (s)-1 (. )-10 (I)13 (f )]TJ -0.004 Tc 0.004 Tw 0 -1.17 TD [(an)-4 (t)-6 (h)-4 (r)-1 (ac)-20 (y)16 (cl)-6 (i)-6 (n)-14 (es)-5 ( ar)-11 (e u)-4 (s)-5 (ed)-3.9 (,)-4 ( t)-16 (h)-4 (e p)-4 (at)-6 (i)-6 (en)-4 (t)-16 (')6 (s )]TJ 0 Tc 0 Tw 14.84 0 Td [(c)4 (a)-6 (r)3 (di)-2 (a)4 (c)4 ( f)3 (un)-10 (c)4 (t)-2 (i)-2 (on s)-1 (houl)-2 (d be)4 ( m)-2 (oni)-2 (t)-2 (or)3 (e)4 (d c)-6 (a)4 (r)3 (e)4 (f)3 (ul)-2 (l)-22 (y)20 (. )]TJ EMC /P <>BDC /TT1 1 Tf 14.04 0 0 14.04 95.7489 408.4303 Tm (8 )Tj -0.004 Tc 0.002 Tw 3.846 0 Td [(US)-3.5 (E)-3.7 ( I)-8.2 (N S)-3.5 (PE)-3.7 (CI)-8.2 (FI)-8.2 (C PO)]TJ 0.004 Tw 9.838 0 Td [(PUL)-3.6 (AT)-3.7 (I)-8.1 (O)-3.8 (NS )]TJ EMC /Span <>BDC -0.002 Tc 0.002 Tw -13.683 -2 Td [(8)-6.3 (.1 )]TJ EMC /Span <>BDC 0.001 Tc 0 Tw 3.846 0 Td [(P)5.2 (r)0.5 (e)0.6 (g)-3.3 (n)10 (a)-3.2 (n)1.4 (c)9.1 (y )]TJ EMC /StyleSpan <>BDC /TT0 1 Tf 0.002 Tc -0.002 Tw 12 0 0 12 95.7489 359.9503 Tm [(R)-1 (is)1 (k)2 ( S)-2 (u)2 (mma)6 (r)-5 (y )]TJ EMC /P <>BDC 0 Tc 0 Tw 0 -1.66 TD [(T)1 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (s )-1 (c)4 (a)-6 (n c)4 (a)4 (us)-1 (e)4 ( f)-7 (e)4 (t)-2 (a)4 (l)-2 ( ha)4 (r)3 (m)-2 ( w)2 (h)-10 (e)4 (n )-10 (a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d t)-2 (o a)4 ( pr)3 (e)-6 (g)10 (n)-10 (a)-6 (nt)-2 ( w)2 (om)-2 (a)4 (n. )-10 (I)13 (n pos)-1 (t)-2 (-)]TJ 0 -1.17 TD [(m)-2 (a)4 (r)3 (ke)4 (t)-2 (i)-2 (ng r)3 (e)4 (por)3 (t)-2 (s)-1 (, us)-1 (e)4 ( o)-10 (f )-7 (t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b dur)3 (i)-2 (ng)10 ( pr)-7 (e)-6 (gna)4 (nc)-16 (y)20 ( r)3 (e)4 (s)-1 (ul)-2 (t)-2 (e)4 (d i)-2 (n )-10 (c)4 (a)4 (s)-1 (e)4 (s)-1 ( o)-10 (f)3 ( ol)-2 (i)-2 (g)10 (oh)-20 (y)20 (dr)-7 (a)4 (m)-2 (ni)-2 (os )]TJ T* [(a)4 (nd of)3 ( ol)-2 (i)-2 (g)10 (oh)-20 (y)20 (d)-10 (r)3 (a)4 (m)-2 (ni)-2 (os)-1 ( s)-1 (e)4 (que)4 (nc)-6 (e)4 (, m)-2 (a)4 (ni)-2 (f)3 (e)4 (s)-1 (t)-2 (i)-2 (n)-10 (g)10 ( a)4 (s )-11 (pul)-2 (m)-2 (ona)4 (r)-7 (y)20 ( h)-20 (y)20 (popl)-2 (a)4 (s)-1 (i)-12 (a)4 (, s)-1 (ke)4 (l)-2 (e)4 (t)-2 (a)4 (l)-2 ( a)4 (bnor)3 (m)-2 (a)4 (l)-2 (i)-2 (t)-2 (i)-2 (e)4 (s)-1 (, )]TJ -0.004 Tc 0.004 Tw 0 -1.16 TD [(an)-4 (d)-4 ( n)-4 (eo)-4 (n)-4 (at)-6 (al)-6 ( d)-14 (eat)-6 (h )]TJ /TT3 1 Tf 7.74 0 Td [([)-5 (s)-5 (ee )]TJ -0.002 Tc 0.002 Tw 1.92 0 Td [(Da)-2 (t)-4 (a)]TJ -0.01 Tc 0.01 Tw 1.98 0 Td [(])-51 (. )]TJ /TT0 1 Tf 0 Tc 0 Tw [(A)2 (ppr)3 (i)-2 (s)-1 (e)4 ( t)-2 (he)4 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 ( of)3 ( t)-2 (he)4 ( pot)-2 (e)4 (nt)-2 (i)-2 (a)4 (l)-2 ( r)3 (i)-2 (s)-1 (ks)-1 ( t)-2 (o a)4 ( f)3 (e)4 (t)-2 (us)-1 (. T)1 (he)-6 (r)3 (e)4 ( a)-6 (r)3 (e )]TJ 0.002 Tc -0.002 Tw -11.64 -1.17 Td [(c)6 (lin)2 (ic)6 (a)6 (l c)6 (o)2 (n)2 (s)1 (id)2 (e)6 (r)5 (a)6 (tio)2 (n)2 (s)1 ( if )-5 (a )]TJ 0 Tc 0 Tw 10.77 0 Td [(t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t )-2 (i)-2 (s)-1 ( us)-1 (e)4 (d i)-2 (n a)4 ( pr)3 (e)-6 (g)10 (n)-10 (a)4 (nt)-2 ( w)2 (om)-2 (a)-6 (n or)3 ( i)-2 (f)3 ( a)4 ( pa)4 (t)-2 (i)-2 (e)4 (nt )]TJ -10.77 -1.17 Td [(be)4 (c)4 (om)-2 (e)4 (s)-1 ( pr)-7 (e)-6 (g)10 (na)4 (nt)-2 ( w)2 (i)-2 (t)-2 (hi)-2 (n 7 m)-2 (ont)-2 (hs)-1 ( f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng)10 ( t)-2 (h)]TJ -0.004 Tc 0.004 Tw [(e l)-6 (as)-5 (t)-6 ( d)-4 (o)-4 (s)-5 (e o)-4 (f)-1 ( a )]TJ 0 Tc 0 Tw [(t)-2 (r)-7 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t )]TJ /TT3 1 Tf -0.004 Tc 0.004 Tw 33.79 0 Td [([)-5 (s)-5 (ee )]TJ 0.002 Tc -0.002 Tw [(C)-1 (lin)2 (ic)6 (a)2 (l )]TJ 0 Tc 0 Tw -33.79 -1.17 Td [(C)-3 (ons)-1 (i)-2 (de)4 (r)-1 (at)-2 (i)-2 (ons)]TJ 0.041 Tc -0.041 Tw 6.09 0 Td (]. )Tj EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw -6.09 -1.66 Td [(T)1 (he)4 ( e)4 (s)-1 (t)-2 (i)-2 (m)-2 (a)4 (t)-2 (e)4 (d ba)4 (c)-6 (k)-10 (g)10 (r)3 (oun)-10 (d r)3 (i)-2 (s)-1 (k of)3 ( m)-2 (a)4 (j)-2 (or)3 ( bi)-2 (r)3 (t)-2 (h de)4 (f)-7 (e)]TJ -0.004 Tc 0.004 Tw 20.14 0 Td [(ct)-6 (s)-5 ( an)-4 (d)-4 ( m)-6 (i)-6 (s)-5 (car)-1 (r)-1 (i)-16 (a)-10 (g)6 (e f)-1 (o)-14 (r)-1 ( t)-6 (h)-3.9 (e i)-6.1 (n)-4 (d)-3.9 (i)-6 (cat)-6 (ed )]TJ 0 Tc 0 Tw -20.14 -1.17 Td [(popul)-2 (a)4 (t)-2 (i)-2 (on i)-2 (s)-1 ( unknow)2 (n. )-10 (I)13 (n t)-2 (he)4 ( U)2 (.S)-4 (. g)10 (e)4 (n)-10 (e)4 (r)-7 (a)4 (l)-2 ( popul)-2 (a)4 (t)-2 (i)-2 (on, t)-2 (he)4 ( e)4 (s)-1 (t)-2 (i)-2 (m)-2 (a)4 (t)-2 (e)4 (d ba)4 (c)4 (k)-10 (gr)3 (ound r)3 (i)-2 (s)-1 (k of)3 ( m)-2 (a)4 (j)-2 (or )]TJ -0.004 Tc 0.004 Tw T* [(b)-4 (i)-6 (r)-1 (t)-6 (h)-4 ( d)-4 (ef)-1 (ect)-6 (s)-5 ( an)-4 (d )]TJ 0 Tc 0 Tw 6.9 0 Td [(m)-2 (i)-2 (s)-1 (c)-6 (a)4 (r)3 (r)3 (i)-12 (a)4 (ge)4 ( i)-2 (n c)4 (l)-2 (i)-2 (ni)-2 (c)4 (a)4 (l)-2 (l)-22 (y)20 ( r)3 (e)-6 (c)4 (o)-10 (g)10 (ni)-2 (z)-6 (e)4 (d pr)3 (e)-6 (g)10 (na)4 (n)-10 (c)4 (i)-2 (e)4 (s)-1 ( i)-2 (s)-1 ( 2%)3 ( t)-2 (o )-10 (4%)3 ( a)4 (nd 15%)3 ( t)-2 (o 20%)3 (, )]TJ -0.004 Tc 0.004 Tw -6.9 -1.17 Td [(r)-1 (es)-5 (p)-4 (ect)-6 (i)-6 (v)-4 (el)-26 (y)16 (. )]TJ EMC /StyleSpan <>BDC 0.002 Tc -0.002 Tw 0 -2.17 TD [(C)-1 (lin)2 (ic)6 (a)6 (l C)-1 (o)2 (n)2 (s)1 (id)]TJ -0.004 Tc 0.004 Tw 6.26 0 Td [(er)-1 (at)-6 (i)-6 (o)-4 (n)-4 (s )]TJ EMC /P <>BDC /TT3 1 Tf 0 Tc 0 Tw -6.26 -1.67 Td [(F)1 (e)4 (t)-2 (al)-2 (/)-2 (N)-3 (e)4 (onat)-2 (al)-2 ( A)1 (dv)4 (e)4 (r)-1 (s)-1 (e )-6 (R)1 (e)4 (ac)4 (t)-2 (i)-2 (ons )]TJ EMC /P <>BDC /TT0 1 Tf 0 -1.66 TD [(M)-1 (oni)-2 (t)-2 (or)3 ( w)2 (om)-2 (e)4 (n w)2 (ho r)3 (e)-6 (c)-6 (e)4 (i)-2 (ve)4 (d H)2 (E)1 (R)-13 (Z)11 (U)2 (M)-1 (A)2 ( dur)3 (i)-2 (n)-10 (g pr)3 (e)-6 (g)10 (na)4 (nc)-16 (y)20 ( o)-10 (r)3 ( w)2 (i)-2 (t)-2 (hi)-2 (n 7 m)-2 (ont)-2 (hs)-1 ( pr)3 (i)-2 (or)3 ( t)-2 (o )]TJ 0 -1.17 TD [(c)4 (onc)4 (e)4 (pt)-2 (i)-2 (on f)3 (or)3 ( ol)-2 (i)-12 (g)10 (oh)-20 (y)20 (dr)-7 (a)4 (m)-2 (ni)-2 (os)-1 (. )-10 (I)13 (f)3 ( ol)-2 (i)-2 (g)10 (oh)-20 (y)20 (dr)-7 (a)4 (m)-2 (ni)-2 (os)-1 ( oc)4 (c)4 (ur)3 (s)-1 (, pe)-6 (r)3 (f)3 (or)3 (m)-2 ( f)-7 (e)4 (t)-2 (a)4 (l)-2 ( t)-2 (e)4 (s)-1 (t)-2 (i)-2 (ng)10 ( t)-2 (ha)4 (t)-2 ( i)-2 (s )]TJ -0.004 Tc 0.014 Tw T* [(ap)-4 (p)-4 (r)-1 (o)-4 (p)-4 (r)-1 (i)-6 (at)-6 (e f)-1 (o)-4 (r)-1 ( g)6.1 (es)-4.9 (t)-6 (at)-6 (i)-6 (o)-4 (n)-14 (al )4 (a)-10 (g)6 (e )10 (an)-4 (d)-4 ( co)-4 (n)-4 (s)-5 (i)-6 (s)-5 (t)-6 (en)]TJ 0 Tc 0 Tw 17.85 0 Td [(t)-2 ( w)2 (i)-2 (t)-2 (h c)4 (om)-2 (m)-2 (uni)-2 (t)-12 (y)20 ( s)-1 (t)-2 (a)4 (nda)4 (r)3 (ds)-1 ( o)-10 (f)3 ( c)4 (a)4 (r)-7 (e)4 (. )]TJ EMC /Artifact <>BDC 1.15 -3.74 Td (18)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 33.7489 26.3903 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4650 0 obj <>>>/Resources 4522 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4651 0 obj <> endobj 4652 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
 endstream endobj 4653 0 obj <> endobj 4654 0 obj <>stream q 1 0 0 1 21.528534 16.968689 cm 0 0 612 792 re W n 1 0 0 1 -21.528534 -16.968689 cm BT /Artifact <>BDC /CS0 cs 0 scn /TT0 1 Tf 3 Tr 12 0 0 12 93.5285 55.6087 Tm ( )Tj 20 0 Td ( )Tj 19 0 Td ( )Tj -23.7 55.83 Td ( )Tj -0.004 Tc 0.004 Tw 23.2 0 Td ( )Tj 0 Tc 0 Tw -29.07 -1.16 Td ( )Tj 14.08 0 Td ( )Tj 13.16 0 Td ( )Tj -30.63 -1.17 Td ( )Tj 14 0 Td ( )Tj 17.05 0 Td ( )Tj -0.004 Tc 0.004 Tw -2.66 -2.33 Td ( )Tj 0 Tc 0 Tw -28.22 -1.17 Td ( )Tj 13.4 0 Td ( )Tj -10.61 -2.17 Td ( )Tj 29.78 -1.66 Td ( )Tj 0.002 Tc -0.002 Tw -30.68 -1.17 Td ( )Tj 0 Tc 0 Tw 5.15 0 Td ( )Tj 13.16 -1.17 Td [( )-840 ( )]TJ 11 0 Td ( )Tj -35.99 -1.17 Td ( )Tj 2.3 -2.16 Td ( )Tj 13.37 -1.67 Td ( )Tj 12.72 0 Td ( )Tj -11.3 -1.16 Td ( )Tj 17.86 0 Td ( )Tj -26.58 -1.17 Td ( )Tj -0.004 Tc 0.004 Tw 19.88 0 Td [( )-3720 ( )]TJ 0 Tc 0 Tw 9.12 0 Td ( )Tj -18.8 -1.17 Td ( )Tj -12.44 -1.16 Td ( )Tj 30.86 0 Td ( )Tj -18.92 -1.17 Td ( )Tj 7.33 0 Td [( )-4900 ( )]TJ -0.004 Tc 0.004 Tw 11.98 0 Td ( )Tj -18.93 -1.17 Td ( )Tj 0 Tc 0 Tw -9.85 -1.16 Td ( )Tj 0.002 Tc -0.002 Tw 8.35 0 Td ( )Tj 0 Tc 0 Tw 5.15 0 Td ( )Tj 14.2 0 Td ( )Tj -0.004 Tc 0.004 Tw -24.51 -1.17 Td ( )Tj 0 Tc 0 Tw 3.12 0 Td ( )Tj -10.53 -2.17 Td ( )Tj 19.43 -1.66 Td ( )Tj 6.5 0 Td [( )-4640 ( )]TJ -4.16 -1.17 Td ( )Tj 10.24 0 Td ( )Tj -36.81 -1.17 Td ( )Tj 0.002 Tc -0.002 Tw 10.33 0 Td ( )Tj 0 Tc 0 Tw 5.14 0 Td ( )Tj 20.66 0 Td ( )Tj -13.48 -1.16 Td ( )Tj 14.21 0 Td ( )Tj -15.84 -1.17 Td ( )Tj /TT1 1 Tf 14.04 0 0 14.04 111.0504 279.8887 Tm ( )Tj 9.581 0 Td ( )Tj /TT0 1 Tf 12 0 0 12 521.5684 259.4887 Tm ( )Tj -5.25 -1.16 Td [( )-2310 ( )]TJ -14.63 -1.17 Td [( )-3500 ( )]TJ 0.002 Tc -0.002 Tw 22.29 0 Td ( )Tj 0 Tc 0 Tw -9.05 -3.5 Td ( )Tj 8.67 0 Td ( )Tj -5.93 -1.17 Td ( )Tj -27.03 -1.66 Td ( )Tj -0.004 Tc 0.004 Tw 3.19 0 Td ( )Tj 8.97 0 Td [( )-2860 ( )]TJ 0 Tc 0 Tw -12.01 -1.17 Td ( )Tj -0.004 Tc 0.004 Tw 33.34 -1.17 Td ( )Tj 0 Tc 0 Tw -20.04 -1.17 Td ( )Tj EMC /Span <>BDC 0 Tr -18.19 51.01 Td [(A)2 (m)-2 (ong)10 ( w)2 (om)-2 (e)4 (n )-10 (r)3 (e)-6 (c)4 (e)4 (i)-2 (vi)-2 (ng )]TJ 0.002 Tc -0.002 Tw [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ -0.004 Tc 0.004 Tw 15.55 0 Td [(f)-1 (o)-4 (r)-1 ( t)-6 (r)-1 (eat)-6 (m)-6 (e)-10 (n)-4 (t)-6 ( o)-4 (f)-1 ( m)-6 (et)-6 (as)-5 (t)-6 (at)-6 (i)-6 (c b)-3.9 (r)-1 (e)-10 (as)-5 (t)-6 ( ca)-10 (n)-4 (cer)-1 (,)-4 ( t)-6 (h)-4 (e i)-6 (n)-4 (ci)-6 (d)-14 (en)-4 (ce o)-14 (f )]TJ 0 Tc 0 Tw -15.55 -1.16 Td [(pul)-2 (m)-2 (ona)4 (r)-7 (y)20 ( t)-2 (ox)-10 (i)-2 (c)4 (i)-2 (t)-12 (y)20 ( w)2 (a)4 (s )-11 (a)-6 (l)-2 (s)-1 (o i)-2 (nc)4 (r)3 (e)4 (a)4 (s)-1 (e)4 (d. P)-4 (ul)-2 (m)-2 (ona)4 (r)-17 (y)10 ( a)4 (dve)4 (r)3 (s)-1 (e )-6 (e)4 (ve)4 (nt)-2 (s)-1 ( ha)4 (v)-10 (e)4 ( be)4 (e)-6 (n r)3 (e)4 (por)3 (t)-2 (e)4 (d i)-2 (n t)-2 (he )]TJ 0 -1.17 TD [(pos)-1 (t)-2 (-)3 (m)-2 (a)4 (r)3 (ke)4 (t)-2 (i)-2 (ng e)4 (x)-10 (pe)4 (r)3 (i)-2 (e)4 (nc)-6 (e)4 ( a)4 (s)-1 ( pa)4 (r)3 (t)-2 ( of)3 ( t)-2 (h)-10 (e)4 ( s)-21 (y)30 (m)-2 (pt)-2 (om )-12 (c)4 (om)-2 (pl)-2 (e)4 (x)-10 ( of)3 ( i)-2 (nf)3 (us)-1 (i)-2 (on r)3 (e)4 (a)4 (c)-6 (t)-2 (i)-2 (ons)-1 (. P)-4 (ul)-2 (m)-2 (ona)4 (r)-7 (y )]TJ T* [(e)4 (ve)4 (nt)-2 (s)-1 ( i)-2 (nc)4 (l)-2 (ude)4 ( br)3 (on)-10 (c)4 (hos)-1 (pa)4 (s)-1 (m)-2 (, h)-10 (y)20 (pox)-10 (i)-2 (a)4 (, d)-10 (y)20 (s)-1 (pn)-10 (e)4 (a)4 (, p)-10 (ul)-2 (m)-2 (ona)4 (r)-7 (y)20 ( i)-2 (nf)3 (i)-2 (l)-2 (t)-2 (r)3 (a)4 (t)-12 (e)4 (s)-1 (, pl)-2 (e)4 (u)-10 (r)3 (a)4 (l)-2 ( e)4 (f)3 (f)3 (us)-1 (i)-2 (ons)-1 (, non\255)]TJ 0 -1.16 TD [(c)4 (a)4 (r)3 (di)-2 (o)-10 (g)10 (e)4 (ni)-2 (c)4 ( pul)-2 (m)-2 (ona)-6 (r)-17 (y)20 ( e)-6 (de)4 (m)-2 (a)4 (, a)4 (nd a)-6 (c)4 (ut)-2 (e)4 ( r)-7 (e)4 (s)-1 (pi)-2 (r)3 (a)4 (t)-2 (o)-10 (r)-7 (y)20 ( di)-2 (s)-1 (t)-2 (r)3 (e)4 (s)-1 (s)-1 ( s)-21 (y)20 (nd)]TJ -0.004 Tc 0.004 Tw 26.38 0 Td [(r)-1 (o)-4 (m)-6 (e.)-4 ( F)2 (o)-14 (r)-11 ( a d)-4 (et)-6 (ai)-6 (l)-6 (ed )]TJ 0 Tc 0 Tw -26.38 -1.17 Td [(de)4 (s)-1 (c)4 (r)3 (i)-2 (pt)-2 (i)-2 (on, s)-1 (e)4 (e )]TJ /TT2 1 Tf 6.47 0 Td [(W)13 (ar)-1 (ni)-2 (ng)-10 (s)-1 ( and P)1 (r)-1 (e)4 (c)4 (aut)-2 (i)-2 (on)]TJ 0.001 Tc 0.009 Tw (s \()Tj 0 Tc 0 Tw 11.3 0 Td [(5.4)-10 (\))]TJ /TT0 1 Tf 1.58 0 Td (. )Tj EMC /P <>BDC /TT2 1 Tf -19.35 -2.17 Td [(T)-4 (hr)-1 (om)2 (bos)-1 (i)-2 (s)-1 (/)-2 (E)1 (m)2 (bol)-2 (i)-2 (s)-1 (m )]TJ EMC /P <>BDC /TT0 1 Tf 0 -1.66 TD [(I)13 (n 4 )-10 (r)3 (a)4 (ndom)-2 (i)-2 (z)-6 (e)4 (d, c)4 (ont)-2 (r)3 (ol)-2 (l)-2 (e)4 (d c)4 (l)-2 (i)-2 (ni)-2 (c)4 (a)4 (l)-2 ( t)-2 (r)3 (i)-2 (a)4 (l)-2 (s)-1 (, t)-2 (he)4 ( i)-2 (nc)4 (i)-12 (de)4 (nc)4 (e)4 ( of)3 ( t)-2 (h)-10 (r)3 (om)-2 (bot)-2 (i)-2 (c)4 ( a)4 (dve)-6 (r)3 (s)-1 (e)4 ( e)4 (ve)4 (nt)-2 (s)-1 ( w)-8 (a)4 (s)-1 ( hi)-2 (g)10 (h)-10 (e)4 (r )]TJ 0.002 Tc -0.002 Tw 0 -1.17 TD [(in)2 ( p)2 (a)6 (tie)6 (n)2 (ts)1 ( r)5 (e)6 (c)6 (e)6 (iv)2 (in)-8 (g )]TJ -0.004 Tc 0.004 Tw 8.35 0 Td [(t)-6 (r)-1 (as)-5 (t)-16 (u)-4 (z)-10 (u)-4 (m)-6 (ab )-4 (an)-4 (d)-4 ( ch)-4 (em)-6 (o)-4 (t)-6 (h)-4 (er)-1 (a)-10 (p)-14 (y)16 ( co)-4 (m)-6 (p)-14 (ar)-0.9 (ed)-4 ( t)-6.1 (o)-3.9 ( ch)-14 (em)-6 (o)-4 (t)-6 (h)-4 (er)-1 (ap)-24 (y)16 ( al)-6 (o)-4 (n)-14 (e i)-6 (n)-4 ( t)-6 (h)-4 (r)-1 (ee )]TJ 0 Tc 0 Tw -8.35 -1.17 Td [(s)-1 (t)-2 (udi)-2 (e)4 (s)-1 ( \()3 (2.6%)3 ( vs)-1 (. 1.5%)3 ( [)-7 (S)-4 (t)-2 (ud)-10 (y)30 ( 1])-7 (, 2.5%)3 ( a)4 (nd 3.7)-10 (%)-7 ( vs)-1 (. 2.2%)3 ( [)-7 (S)-4 (t)-2 (ud)-10 (y )30 (4] )-7 (a)4 (nd 2)-10 (.1%)3 ( vs)-1 (. 0%)3 ( [)-7 (S)-4 (t)-2 (ud)-10 (y )]TJ -0.003 Tc T* [(5)-3 (])-10 (\). )]TJ EMC /P <>BDC /TT2 1 Tf 0 Tc 0 -2.16 TD [(D)2 (i)-2 (ar)-1 (r)-1 (he)4 (a )]TJ EMC /P <>BDC /TT0 1 Tf 0 -1.67 TD [(A)2 (m)-2 (ong)10 ( w)2 (om)-2 (e)4 (n )-10 (r)3 (e)-6 (c)4 (e)4 (i)-2 (vi)-2 (ng a)4 (dj)-2 (uva)4 (nt)-2 ( t)-2 (he)4 (r)3 (a)4 (p)-20 (y )10 (f)3 (or)3 ( br)-7 (e)-6 (a)4 (s)-1 (t)-2 ( c)4 (a)4 (nc)-6 (e)4 (r)3 (, t)-2 (he)4 ( i)-2 (nc)4 (i)-2 (de)4 (n)-10 (c)4 (e )-6 (of)3 ( N)2 (C)-13 (I)13 (-)]TJ -0.004 Tc 0.004 Tw 33.2 0 Td [(C)-7 (T)-3 (C)-7 ( G)-2 (r)-1 (ad)-14 (e )]TJ 0 Tc 0 Tw -33.2 -1.16 Td [(2\2265 di)-2 (a)4 (r)3 (r)3 (he)-6 (a)4 ( \()3 (6.7%)3 ( vs)-1 (. 5.)-10 (4%)3 ( [)-7 (S)-4 (t)-2 (ud)-10 (y)30 ( 1])-7 (\))3 ( a)4 (nd of )-7 (N)2 (C)-3 (I)13 (-)]TJ -0.004 Tc 0.004 Tw 20.81 0 Td [(C)-7 (T)-3 (C)-7 ( G)-12 (r)-1 (ad)-4 (e 3)]TJ 0 Tc 0 Tw 5.39 0 Td [(\2265 di)-12 (a)4 (r)3 (r)3 (h)-10 (e)-6 (a)4 ( \()3 (2.2%)3 ( vs)-1 (. 0% )]TJ -26.2 -1.17 Td [([)-7 (S)-4 (t)-2 (ud)-10 (y)30 ( 2])-7 (\))3 (, a)4 (nd of)3 ( G)-8 (r)3 (a)4 (de )-6 (1\226)]TJ -0.003 Tc 0.003 Tw [(4)-3 ( d)-3 (i)-5 (a)1 (rrh)-3 (e)-9.1 (a)1 ( \(7)-3 (% v)]TJ -0.004 Tc 0.004 Tw 17.73 0 Td [(s)-5 (.)-4 ( 1)-4 (%)-11 (\))-1 ( w)-2 (er)-11 (e h)-4 (i)-6 (g)6 (h)-14 (er)-1 ( i)-6 (n)-4 ( p)-4 (at)-6 (i)-6 (en)-3.9 (t)-6.1 (s )-14.9 (r)-1 (ecei)-6 (v)-4 (i)-6 (n)-14 (g )]TJ 0.002 Tc -0.002 Tw 16.16 0 Td [(tr)-5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6.1 (b )]TJ 0 Tc 0 Tw -33.89 -1.17 Td [(a)4 (s)-1 ( c)4 (om)-2 (pa)4 (r)-7 (e)4 (d t)-2 (o c)4 (ont)-2 (r)3 (ol)-2 (s)-1 (. )-10 (I)13 (n S)-4 (t)-2 (ud)-20 (y)20 ( 4, t)-2 (he)4 ( i)-2 (nc)4 (i)-2 (de)4 (n)-10 (c)4 (e )-6 (of)3 ( G)2 (r)3 (a)4 (d)-10 (e)4 ( 3\2264 di)-2 (a)4 (r)3 (r)3 (h)-10 (e)4 (a)4 ( w)-8 (a)-6 (s)-1 ( hi)-2 (g)10 (he)4 (r)3 ( [)-7 (5.7%)3 ( A)2 (C)-3 (\255)]TJ 0 -1.16 TD [(T)1 (H)2 (, 5.5%)3 ( T)1 (C)-3 (H)2 ( vs)-1 (. )]TJ 0.01 Tw [(3.0%)3 ( A)2 (C)]TJ 0 Tw 11.53 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.33 0 Td [(T)-3 (])-11 ( an)-4 (d)-4 ( o)-4 (f)-1 ( G)-2 (r)-1 (ad)-14 (e 1)]TJ 0 Tc 0 Tw 7.16 0 Td [(\2264 )-10 (w)2 (a)4 (s)-1 ( hi)-2 (g)10 (h)-10 (e)4 (r)3 ( [)-7 (51%)3 ( A)2 (C)-3 (-)3 (T)1 (H)-8 (, 63%)3 ( T)1 (C)-3 (H)2 ( vs)-1 (. 43% )]TJ -0.002 Tc 0.002 Tw -19.02 -1.17 Td (AC)Tj 0 Tc 0 Tw 1.39 0 Td [(-)3 (T)1 (])-7 ( a)4 (m)-2 (ong)10 ( w)2 (om)-2 (e)4 (n )-10 (r)3 (e)-6 (c)4 (e)4 (i)-2 (vi)-2 (n)]TJ -0.01 Tc 0.01 Tw (g )Tj 0.002 Tc -0.002 Tw [(tr)-5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b)]TJ 0 Tc 0 Tw 16.55 0 Td [(. O)2 (f )-7 (pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( r)3 (e)4 (c)-6 (e)4 (i)-2 (vi)-2 (ng )]TJ 0.002 Tc -0.002 Tw 9.13 0 Td [(tr)-5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ -0.004 Tc 0.004 Tw 5.15 0 Td [(as)-5 ( a s)-5 (i)-6 (n)-14 (g)6 (l)-6 (e a)-10 (g)-4 (en)-4 (t )]TJ -32.22 -1.17 Td [(f)-1 (o)-4 (r)-1 ( t)-6 (h)-4 (e t)-6 (r)-1 (e)-10 (at)-6 (m)-6 (en)-4 (t)-6 ( o)-4 (f)-1 ( m)-6 (et)-6 (a)-9.9 (s)-5.1 (t)-5.9 (at)-6.1 (i)-5.9 (c b)-4 (r)-1 (eas)-5 (t)-6 ( c)-10 (an)-4 (ce)-10 (r)-1 (,)-4 ( 2)-4 (5)-4 (% )-11 (ex)-14 (p)-4 (er)-1 (i)-6 (en)-4 (ced)-4 ( d)-4 (i)-6 (a)-10 (r)-1 (r)-1 (h)-4 (e)-10 (a.)-4 ( A)-2 (n)-14 ( i)-6 (n)-4 (cr)-0.9 (eas)-15 (ed)-4 ( i)-6 (n)-4 (ci)-6 (d)-4 (en)-4 (c)-10 (e )]TJ 0 Tc 0 Tw T* [(of)3 ( di)-2 (a)4 (r)3 (r)3 (he)-6 (a)4 ( w)2 (a)4 (s)-1 ( obs)-11 (e)4 (r)3 (ve)4 (d )]TJ 0.002 Tc -0.002 Tw 10.27 0 Td [(in)2 ( p)2 (a)6 (tie)6 (n)2 (ts)1 ( r)5 (e)6 (c)6 (e)6 (iv)2 (in)-8 (g )12 (tr)5 (a)6 (s)-9 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 13.5 0 Td [(i)-2 (n c)4 (om)-2 (bi)-2 (na)4 (t)-2 (i)-2 (on )10 (w)2 (i)-2 (t)-2 (h c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y )]TJ -23.77 -1.17 Td (f)Tj -0.004 Tc 0.004 Tw 0.33 0 Td [(o)-4 (r)-1 ( t)-6 (r)-1 (eat)-6 (m)-6 (en)-4 (t)-6 ( o)-14 (f)-1 ( m)-6 (et)-6 (as)-5 (t)-6 (at)-6 (i)-16 (c b)-3.9 (r)-1 (eas)-5 (t )-16 (can)-4 (c)-10 (er)-1 (. )]TJ EMC /P <>BDC /TT2 1 Tf 0.002 Tc -0.002 Tw -0.33 -2.17 Td [(R)3 (e)6 (n)2 (a)2 (l T)-2 (o)2 (x)6 (ic)6 (ity )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw 0 -1.66 TD [(I)13 (n t)-2 (he)4 ( pos)-1 (t)-12 (-)3 (m)-2 (a)4 (r)3 (ke)4 (t)-2 (i)-2 (n)-10 (g)10 ( s)-1 (e)4 (t)-12 (t)-2 (i)-2 (ng)10 (, r)3 (a)-6 (r)3 (e)4 ( c)-6 (a)4 (s)-1 (e)4 (s)-1 ( of)3 ( n)-10 (e)4 (phr)3 (o)-10 (t)-2 (i)-2 (c)4 ( s)-11 (y)20 (ndr)3 (om)-2 (e )-6 (w)2 (i)-2 (t)-2 (h pa)4 (t)-2 (hol)-2 (og)10 (i)-2 (c )-6 (e)4 (vi)-2 (de)4 (nc)-6 (e)4 ( of )]TJ 0 -1.17 TD [(g)10 (l)-2 (om)-2 (e)4 (r)3 (ul)-2 (opa)4 (t)-2 (h)-20 (y)20 ( h)-10 (a)4 (ve)4 ( be)-6 (e)-6 (n r)3 (e)4 (por)3 (t)-2 (e)4 (d. T)1 (h)-10 (e)4 ( t)-2 (i)-2 (m)-2 (e)4 ( t)-2 (o ons)-1 (e)4 (t)-2 ( r)3 (a)4 (n)-10 (g)10 (e)4 (d f)-7 (r)3 (om)-2 ( 4 m)-2 (ont)-2 (hs)-1 ( t)-2 (o a)4 (ppr)3 (ox)-10 (i)-2 (m)-2 (a)4 (t)-2 (e)4 (l)-12 (y )]TJ T* [(18 m)-2 (ont)-2 (hs)-1 ( f)3 (r)3 (om)-2 ( i)]TJ 0.002 Tc -0.002 Tw 6.92 0 Td [(n)2 (itia)6 (tio)12 (n)2 ( o)2 (f )5 (tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 9.8 0 Td [(t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 (.)-10 ( P)-4 (a)4 (t)-2 (hol)-2 (og)10 (i)-2 (c)4 ( f)3 (i)-2 (ndi)-2 (n)-10 (g)10 (s)-1 ( i)-2 (nc)4 (l)-12 (ude)4 (d m)-2 (e)4 (m)-2 (br)3 (a)4 (nous )]TJ -16.72 -1.16 Td [(g)10 (l)-2 (om)-2 (e)4 (r)3 (ul)-2 (one)4 (ph)-10 (r)3 (i)-2 (t)-2 (i)-2 (s)-1 (, f)3 (oc)4 (a)4 (l)-12 ( g)10 (l)-2 (om)-2 (e)4 (r)3 (ul)-2 (os)-1 (c)4 (l)-12 (e)4 (r)3 (os)-1 (i)-2 (s)-1 (, a)4 (nd )-10 (f)3 (i)-2 (br)3 (i)-2 (l)-2 (l)-2 (a)4 (r)-7 (y )10 (g)10 (l)-2 (om)-2 (e)-6 (r)3 (ul)-2 (one)4 (phr)-7 (i)-2 (t)-2 (i)-2 (s)-1 (. C)-3 (om)-2 (pl)8 (i)-2 (c)4 (a)4 (t)-2 (i)-2 (ons )]TJ T* [(i)-2 (nc)4 (l)-2 (ude)4 (d vol)-2 (um)-2 (e)4 ( ove)4 (r)3 (l)-2 (oa)-6 (d a)4 (nd c)4 (on)-10 (g)10 (e)4 (s)-1 (t)-2 (i)-2 (ve)4 ( he)-6 (a)4 (r)3 (t)-2 ( f)-7 (a)-6 (i)-2 (l)-2 (ur)3 (e)4 (. )]TJ EMC /Span <>BDC /TT1 1 Tf -0.002 Tc 14.04 0 0 14.04 93.5285 279.8887 Tm [(6)-6.3 (.2 )]TJ EMC /Span <>BDC 0.004 Tc 3.846 0 Td [(Im)8 (m)16.5 (u)4.4 (n)4.4 (oge)3.5 (n)13 (ic)3.5 (i)8.5 (t)3.7 (y )]TJ EMC /P <>BDC /TT0 1 Tf 0.002 Tc -0.002 Tw 12 0 0 12 93.5285 259.4887 Tm [(A)4 (s)1 ( w)4 (ith)2 ( a)6 (ll )]TJ 0 Tc 0 Tw [(t)-2 (he)4 (r)3 (a)4 (pe)4 (ut)-2 (i)-2 (c)4 ( pr)-7 (ot)-2 (e)4 (i)-2 (ns)-1 (, t)-2 (he)4 (r)3 (e)4 ( i)-2 (s)-1 ( a)4 ( pot)-2 (e)4 (nt)-2 (i)-2 (a)-6 (l)-2 ( f)3 (or)3 ( i)-2 (m)-2 (m)-2 (unog)10 (e)4 (ni)-2 (c)4 (i)-2 (t)-22 (y)20 (. T)1 (h)-10 (e)4 ( de)4 (t)-2 (e)4 (c)4 (t)-2 (i)-2 (on of )]TJ 0 -1.16 TD [(a)4 (nt)-2 (i)-2 (bod)-10 (y)20 ( f)3 (o)-10 (r)3 (m)-2 (a)4 (t)-2 (i)-2 (on i)-2 (s)-1 ( hi)-2 (ghl)-12 (y)20 ( de)4 (p)-10 (e)4 (nde)4 (nt)-2 ( on t)-2 (he)4 ( s)-1 (e)4 (n)-10 (s)-1 (i)-2 (t)-2 (i)-2 (vi)-2 (t)-12 (y)30 ( a)4 (nd t)-2 (he)4 ( s)-1 (p)-10 (e)4 (c)4 (i)-2 (f)3 (i)-2 (c)4 (i)-2 (t)-12 (y )10 (of)3 ( t)-2 (he )-6 (a)4 (s)-1 (s)-1 (a)-16 (y)20 (. )]TJ 0 -1.17 TD [(A)2 (ddi)-2 (t)-2 (i)-2 (ona)4 (l)-2 (l)-12 (y)20 (, t)-2 (he)4 ( obs)-1 (e)4 (r)3 (v)-10 (e)-6 (d i)-2 (nc)4 (i)-2 (de)4 (nc)4 (e)4 ( of )-7 (a)4 (nt)-2 (i)-2 (bod)-10 (y )10 (\()-7 (i)-2 (nc)4 (l)-2 (udi)-2 (ng)10 ( ne)4 (ut)-2 (r)-7 (a)4 (l)-2 (i)-2 (z)-6 (i)-2 (ng)10 ( a)4 (n)-10 (t)-2 (i)-2 (bod)-10 (y)20 (\))3 ( p)]TJ 0.002 Tc -0.002 Tw [(o)2 (s)1 (itiv)2 (it)-10 (y)22 ( in )]TJ 0 Tc 0 Tw T* [(a)4 (n a)4 (s)-1 (s)-1 (a)-16 (y)20 ( m)-2 (a)-16 (y)20 ( b)-10 (e)4 ( i)-2 (nf)3 (l)-2 (ue)4 (nc)-6 (e)4 (d b)-10 (y)20 ( s)-11 (e)4 (ve)4 (r)-7 (a)4 (l)-2 ( f)3 (a)-6 (c)4 (t)-2 (or)3 (s)-1 ( i)-2 (nc)4 (l)-12 (udi)-2 (ng)10 ( a)4 (s)-1 (s)-1 (a)-16 (y)20 ( m)-12 (e)4 (t)-2 (hodol)-2 (og)-10 (y)10 (, s)-1 (a)4 (m)-2 (pl)-2 (e)4 ( ha)4 (ndl)-2 (i)-2 (ng)10 (, )]TJ 0 -1.16 TD [(t)-2 (i)-2 (m)-2 (i)-2 (ng)10 ( of)3 ( s)-1 (a)4 (m)-2 (pl)-2 (e)4 ( c)4 (ol)-2 (l)-2 (e)4 (c)4 (t)-2 (i)-12 (on, c)4 (onc)4 (om)-2 (i)-2 (t)-2 (a)4 (nt)-2 ( m)-2 (e)4 (di)-2 (c)4 (a)4 (t)-2 (i)-12 (ons)-1 (, a)4 (nd unde)4 (r)3 (l)-22 (y)20 (i)-2 (n)-10 (g)10 ( di)-2 (s)-1 (e)4 (a)-6 (s)-1 (e)4 (. F)6 (or)3 ( t)-2 (he)4 (s)-11 (e)4 ( r)3 (e)-6 (a)4 (s)-1 (ons)-1 (, )]TJ 0 -1.17 TD [(c)4 (om)-2 (pa)4 (r)3 (i)-2 (s)-1 (on of)3 ( t)-2 (he)4 ( i)-2 (nc)4 (i)-2 (de)-6 (nc)4 (e)4 ( of)3 ( a)4 (nt)-2 (i)-2 (bodi)-2 (e)4 (s)-1 ( i)-2 (n t)-2 (he)4 ( s)-11 (t)-2 (udi)-2 (e)4 (s)-1 ( de)4 (s)-1 (c)4 (r)3 (i)-2 (be)4 (d be)4 (l)-2 (ow )-8 (w)-8 (i)-2 (t)-2 (h t)-2 (he)4 ( i)-2 (nc)4 (i)-2 (de)4 (nc)4 (e)4 ( of )]TJ T* [(a)4 (nt)-2 (i)-2 (bodi)-2 (e)4 (s)-1 ( i)-2 (n ot)-2 (he)4 (r)3 ( s)-1 (t)-2 (udi)-2 (e)4 (s)-1 ( or)3 ( t)-2 (o ot)-2 (he)4 (r)3 ( t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (s)-1 ( m)-2 (a)-16 (y)20 ( be)4 ( m)-2 (i)-2 (s)-1 (l)-2 (e)4 (a)4 (d)-10 (i)-2 (ng)10 (. )]TJ EMC /P <>BDC 0 -1.66 TD [(A)2 (m)-2 (ong)10 ( 903 )]TJ -0.004 Tc 0.004 Tw [(w)-2 (o)-4 (m)-6 (en )-14 (w)-2 (i)-6 (t)-6 (h)-4 ( m)-6 (et)-6 (as)-5 (t)-6 (at)-6 (i)-6 (c b)-4 (r)-0.9 (eas)-5 (t )-15.9 (can)-4 (c)-10 (er)-1 (, )-14 (h)-4 (u)-4 (m)-6 (an)-4 ( an)-4 (t)-6 (i)]TJ 0 Tc 0 Tw 24.74 0 Td [(-)3 (hum)-2 (a)4 (n a)4 (nt)-2 (i)-2 (b)-10 (od)-10 (y)20 ( \()-7 (H)2 (A)2 (H)2 (A)-8 (\))3 ( t)-2 (o )]TJ 0.002 Tc -0.002 Tw -24.74 -1.17 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(w)2 (a)4 (s)-1 ( de)4 (t)-2 (e)4 (c)4 (t)-2 (e)-6 (d i)-2 (n one)4 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 ( us)-1 (i)-2 (ng)10 ( a)4 (n )-10 (e)4 (nz)]TJ -0.02 Tc 0.02 Tw 16.08 0 Td [(ym)-22 (e)]TJ 0 Tc 0 Tw 1.7 0 Td [(-)3 (l)-2 (i)-2 (nke)4 (d i)-2 (m)-2 (m)-2 (unos)-11 (or)3 (be)4 (nt)-2 ( a)4 (s)-1 (s)-1 (a)-16 (y)20 ( \()-7 (E)-9 (L)1 (I)13 (S)-4 (A)2 (\))3 (. )]TJ -0.004 Tc 0.004 Tw -22.92 -1.17 Td [(T)-3 (h)-4 (i)-6 (s)-5 ( p)-4 (at)-6 (i)-6 (en)-4 (t)-6 ( d)-4 (i)-6 (d)-4 ( n)-4 (o)-4 (t)-6 ( ex)-14 (p)-4 (e)10 (r)-0.9 (i)-6.1 (en)-3.9 (ce )-10 (an)-4 ( al)-6 (l)-6 (er)-11 (g)6 (i)-6 (c )-10 (r)-1 (e)-10 (act)-6 (i)-6 (o)-14 (n)-4 (.)-4 ( S)-8 (am)-6 (p)-4 (l)-6 (es)-5 ( f)-1 (o)-4 (r)-1 ( as)-5 (s)-5 (es)-5 (s)-5 (m)-6 (en)-14 (t)-6 ( o)-3.9 (f)-1 ( H)-2.1 (A)-2 (H)-1.9 (A)-2 ( w)-12 (er)-1 (e n)-4 (o)-4 (t )]TJ 0 Tc 0 Tw 0 -1.17 TD [(c)4 (ol)-2 (l)-2 (e)4 (c)4 (t)-2 (e)4 (d i)-2 (n s)-1 (t)-2 (udi)-2 (e)4 (s)-1 ( of)3 ( a)4 (dj)-12 (uva)4 (nt)-2 ( br)3 (e)4 (a)4 (s)-1 (t)-2 ( c)-6 (a)4 (nc)-6 (e)4 (r)3 (. )]TJ EMC /Artifact <>BDC 19 -4.82 Td (17)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 31.5285 26.9687 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4655 0 obj <>>>/Resources 4521 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4656 0 obj <> endobj 4657 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
 endstream endobj 4658 0 obj <> endobj 4659 0 obj <>stream q 1 0 0 1 21.372742 16.968567 cm 0 0 612 792 re W n 1 0 0 1 -21.372742 -16.968567 cm BT /Artifact <>BDC /CS0 cs 0 scn /TT0 1 Tf 3 Tr 12 0 0 12 93.3727 55.6086 Tm ( )Tj 20 0 Td ( )Tj 19 0 Td ( )Tj -34.11 55.83 Td ( )Tj 20.15 0 Td ( )Tj 12.95 0 Td ( )Tj 0.002 Tc -0.002 Tw -29.66 -1.16 Td ( )Tj 0 Tc 0 Tw 5.15 0 Td ( )Tj -0.004 Tc 0.004 Tw 25.4 0 Td ( )Tj -34.2 -1.17 Td ( )Tj -0.003 Tc 0.003 Tw 2.65 0 Td ( )Tj 0 Tc 0 Tw 0.26 0 Td ( )Tj -2.59 -2.17 Td ( )Tj 0.002 Tc -0.002 Tw -4.18 -1.66 Td ( )Tj 34.19 0 Td ( )Tj 0 Tc 0 Tw -15.21 -1.17 Td ( )Tj -0.004 Tc 0.004 Tw 10.23 -1.17 Td ( )Tj 0 Tc 0 Tw 5.14 0 Td ( )Tj -29.52 -1.16 Td ( )Tj 23.7 -1.17 Td ( )Tj 9.19 0 Td ( )Tj -32.58 -1.17 Td ( )Tj 10.61 0 Td ( )Tj 18.7 0 Td ( )Tj -24.39 -1.16 Td ( )Tj 22.71 0 Td ( )Tj -25.26 -1.17 Td ( )Tj -4.78 -1.67 Td ( )Tj 16.27 -1.66 Td ( )Tj 15.99 -2.34 Td ( )Tj -30.92 -1.16 Td ( )Tj 20.15 0 Td ( )Tj 12.59 0 Td ( )Tj -32.47 -2.34 Td ( )Tj -1.75 -1.66 Td ( )Tj 16.27 0 Td [( )-2550 ( )-3260 ( )-4360 ( )-4890 ( )]TJ 14.13 -1.17 Td ( )Tj -0.003 Tc 0.003 Tw -13.96 -1.17 Td ( )Tj 0 Tc 0 Tw -17.66 -1.17 Td ( )Tj 6.46 -2.83 Td [( )-4360 ( )]TJ 19.19 0 Td [( )-4900 ( )]TJ 7.41 -1.17 Td ( )Tj -27.33 -2.16 Td ( )Tj 1.68 -1.67 Td [( )-10 ( )]TJ 7.49 -1.66 Td ( )Tj 12.72 0 Td ( )Tj -9.01 -2.34 Td ( )Tj 16.8 0 Td ( )Tj 0.002 Tc -0.002 Tw -26.7 -1.16 Td ( )Tj 0 Tc 0 Tw 5.14 0 Td ( )Tj 19.74 0 Td ( )Tj 0.8 -1.17 Td ( )Tj -12.94 -1.17 Td ( )Tj 5.57 -1.66 Td [( )-4900 ( )]TJ -0.004 Tc 0.004 Tw 9.33 0 Td ( )Tj 0 Tc 0 Tw -21.11 -1.17 Td ( )Tj 12.36 0 Td ( )Tj 5.53 0 Td ( )Tj 0.002 Tc -0.002 Tw 3.36 0 Td ( )Tj -0.004 Tc 0.004 Tw -34.97 -1.17 Td ( )Tj 0 Tc 0 Tw 25.75 0 Td ( )Tj -0.004 Tc 0.004 Tw 6.31 0 Td ( )Tj 0 Tc 0 Tw -35.27 -1.17 Td ( )Tj -0.004 Tc 0.004 Tw 6.93 0 Td ( )Tj 0 Tc 0 Tw 8.59 0 Td ( )Tj -5.97 -2.16 Td ( )Tj EMC /Span <>BDC 0.002 Tc -0.002 Tw 0 Tr -10.05 51.33 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(a)4 (nd c)4 (he)4 (m)-2 (ot)-12 (he)4 (r)3 (a)4 (p)-20 (y)20 ( c)4 (om)-2 (p)-10 (a)4 (r)3 (e)4 (d )-10 (w)2 (i)-2 (t)-2 (h t)-2 (hos)-1 (e)4 ( r)3 (e)4 (c)-6 (e)4 (i)-2 (vi)-2 (ng c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)-7 (a)-6 (p)-10 (y)20 ( a)4 (l)-2 (on)-10 (e)4 (. F)6 (ol)-2 (l)-2 (ow)2 (i)-2 (n)-10 (g )]TJ 0.002 Tc -0.002 Tw -5.14 -1.16 Td [(th)2 (e)6 ( a)6 (d)2 (min)2 (is)1 (tr)5 (a)6 (tio)2 (n)2 ( o)2 (f )5 (tr)5 (a)6 (s)-9 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 13.73 0 Td [(a)4 (s)-1 ( a)4 ( s)-1 (i)-2 (ng)10 (l)-2 (e)4 ( a)-6 (ge)4 (n)-10 (t)-2 ( \()3 (S)-4 (t)-2 (ud)-10 (y)20 ( 6\))3 (, t)-2 (he)4 ( i)-2 (nc)4 (i)-2 (de)4 (n)-10 (c)4 (e)-6 ( of)3 ( N)2 (C)-13 (I)13 (-)]TJ -0.004 Tc 0.004 Tw 19.76 0 Td [(C)-7 (T)-3 (C)-7 ( G)-2 (r)-1 (ad)-14 (e 3 )]TJ -33.49 -1.17 Td [(an)-4 (em)-6 (i)-6 (a w)-2 (as )-15 (< 1)]TJ -0.003 Tc 0.003 Tw 6.25 0 Td (%. )Tj EMC /P <>BDC /TT1 1 Tf 0 Tc 0 Tw -6.25 -2.17 Td [(N)-3 (e)4 (ut)-2 (r)-1 (ope)4 (ni)-2 (a )]TJ EMC /P <>BDC /TT0 1 Tf 0.002 Tc -0.002 Tw 0 -1.66 TD [(I)15 (n )-8 (r)5 (a)6 (n)2 (d)2 (o)2 (miz)-4 (e)6 (d)2 ( c)6 (o)2 (n)2 (tr)5 (o)2 (lle)6 (d)-8 ( c)6 (lin)2 (ic)6 (a)6 (l tr)5 (ia)6 (ls)1 ( in)2 ( th)2 (e)5.9 ( a)6.1 (d)2 (ju)2 (v)2 (a)5.9 (n)2.1 (t s)0.9 (e)6 (ttin)2 (g)12 (,)2 ( th)2 (e)6 ( in)2 (c)6 (id)2 (e)6 (n)-8 (c)-4 (e)6 ( o)2 (f)5 ( s)1 (e)6 (le)-4 (c)6 (te)6 (d )]TJ -0.002 Tc 0.002 Tw 0 -1.17 TD [(NC)-15 (I)]TJ 0 Tc 0 Tw 1.72 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.33 0 Td [(C)-7 (T)-3 (C)-7 ( G)-2 (r)-1 (ad)-4 (e 4)]TJ 0 Tc 0 Tw 5.38 0 Td [(\2265 n)-10 (e)4 (u)-10 (t)-2 (r)3 (ope)4 (ni)-2 (a)4 ( \()3 (1.7%)3 ( vs)-1 (. 0.8)-10 (% )-7 ([)-7 (S)-4 (t)-2 (ud)-10 (y)30 ( 2])-7 (\))3 ( a)4 (nd of)3 ( s)-1 (e)4 (l)-12 (e)4 (c)4 (t)-2 (e)-6 (d G)2 (r)3 (a)4 (de)4 ( 2\2265 )]TJ -7.43 -1.17 Td [(ne)4 (ut)-2 (r)3 (ope)4 (ni)-2 (a)4 ( \()3 (6.4)-10 (%)3 ( vs)-1 (. 4.)-10 (3%)3 ( [)-7 (S)-4 (t)-2 (ud)-10 (y)30 ( 1])-7 (\))3 ( w)2 (e)-6 (r)3 (e)4 ( i)-2 (nc)4 (r)-7 (e)-6 (a)4 (s)-1 (e)4 (d i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( r)]TJ -0.004 Tc 0.004 Tw 26.63 0 Td [(e)-10 (cei)-6 (v)-4 (i)-6 (n)-14 (g )]TJ 0.002 Tc -0.002 Tw 3.65 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(a)4 (nd )]TJ -35.42 -1.16 Td [(c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y )10 (c)4 (om)-2 (pa)4 (r)-7 (e)4 (d )-10 (w)2 (i)-2 (t)-2 (h t)-2 (hos)-1 (e)4 ( r)3 (e)4 (c)4 (e)4 (i)-2 (vi)-2 (n)-10 (g)10 ( c)4 (h)-10 (e)-6 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( a)4 (l)-2 (one)4 (. )-20 (I)13 (n a)4 ( r)-7 (a)-6 (ndom)-2 (i)-2 (z)-6 (e)4 (d, c)4 (ont)-2 (r)3 (ol)-2 (l)-2 (e)4 (d )]TJ 0.002 Tc -0.002 Tw T* [(tr)5 (ia)6 (l in)2 ( p)2 (a)6 (tie)6 (n)2 (ts)1 ( w)4 (ith)2 ( me)6 (ta)6 (s)1 (ta)6 (tic)6 ( b)2 (r)5 (e)6 (a)6 (s)1 (t c)-4 (a)6 (n)2 (c)6 (e)-4 (r)5 (,)2 ( th)2 (e)6.1 ( i)-10 (n)2 (c)6 (id)2.1 (e)5.9 (n)2 (c)6 (e)6 (s)1 ( o)-8 (f)5 ( N)4 (C)-11 (I)]TJ 0 Tc 0 Tw 27.07 0 Td [(-)3 (C)-3 (T)1 (C )-13 (G)2 (r)3 (a)4 (de)4 ( 3/)-2 (4 ne)4 (ut)-12 (r)3 (ope)4 (ni)-2 (a )]TJ -27.07 -1.17 Td [(\()3 (32%)3 ( vs)-1 (. 22%)3 (\) )-7 (a)4 (nd of)3 ( f)-7 (e)-6 (br)3 (i)-2 (l)-2 (e)4 ( ne)4 (ut)-2 (r)3 (ope)4 (ni)-2 (a )-6 (\()3 (23%)3 ( v)-10 (s)-1 (. 17%)3 (\))3 ( w)2 (e)4 (r)-7 (e)4 ( a)4 (l)-2 (s)-1 (o i)-2 (nc)4 (r)-7 (e)4 (a)4 (s)-11 (e)4 (d i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s )]TJ 0 -1.16 TD [(r)3 (a)4 (ndom)-2 (i)-2 (z)-6 (e)4 (d t)-2 (o )]TJ -0.004 Tc 0.004 Tw [(t)-6 (r)-1 (as)-5 (t)-6 (u)-4 (z)-10 (u)-4 (m)4 (ab )]TJ 0 Tc 0 Tw 11.13 0 Td [(i)-2 (n c)4 (om)-2 (bi)-2 (na)4 (t)-2 (i)-2 (on w)2 (i)-2 (t)-2 (h m)-12 (y)20 (e)4 (l)-2 (os)-1 (uppr)-7 (e)4 (s)-1 (s)-1 (i)-2 (ve)4 ( c)4 (he)4 (m)-2 (o)-10 (t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( a)4 (s )-11 (c)4 (om)-2 (pa)4 (r)3 (e)4 (d t)-2 (o )]TJ -0.004 Tc 0.014 Tw -11.13 -1.17 Td [(ch)-4 (em)-6 (o)-4 (t)-6 (h)-4 (er)-1 (ap)-24 (y)16 ( al)-6 (o)-4 (n)-4 (e. )]TJ EMC /P <>BDC /TT1 1 Tf 0.002 Tc 0 Tw 0 -1.67 TD [(I)5 (n)2 (fe)6 (c)6 (tio)2 (n )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 -1.66 TD [(T)1 (he)4 ( ove)4 (r)-7 (a)4 (l)-2 (l)-2 ( i)-2 (nc)4 (i)-2 (de)4 (nc)4 (e)4 (s)-1 ( o)-10 (f)-7 ( i)-2 (nf)3 (e)4 (c)4 (t)-2 (i)-2 (on \()3 (46%)3 ( vs)-1 (. 30% )-7 ([)-7 (S)-4 (t)-2 (ud)-10 (y)30 ( 5])-7 (\))3 (, of)3 ( s)-1 (e)4 (l)-2 (e)-6 (c)4 (t)-2 (e)4 (d N)-8 (C)-13 (I)23 (-)]TJ -0.004 Tc 0.004 Tw 31.26 0 Td [(C)-7 (T)-3 (C)-7 ( G)-2 (r)-11 (ad)-4 (e 2)]TJ 0 Tc 0 Tw 5.39 0 Td (\2265 )Tj -36.65 -1.17 Td [(i)-2 (nf)3 (e)4 (c)4 (t)-2 (i)-2 (on/)-2 (f)3 (e)4 (br)3 (i)-2 (l)-2 (e)4 ( n)-10 (e)4 (ut)-2 (r)3 (ope)-6 (ni)-2 (a)4 ( \()3 (24.3%)3 ( vs)-1 (. 13.4%)3 ( [)-7 (S)-4 (t)-2 (ud)-10 (y)20 ( 1])-7 (\))3 ( a)4 (nd of)3 ( s)-11 (e)4 (l)-2 (e)4 (c)4 (t)-2 (e)4 (d )-10 (G)-8 (r)3 (a)4 (de)4 ( 3\2265 )]TJ 0 -1.17 TD [(i)-2 (nf)3 (e)4 (c)4 (t)-2 (i)-2 (on/)-2 (f)3 (e)4 (br)3 (i)-2 (l)-2 (e)4 ( n)-10 (e)4 (ut)-2 (r)3 (ope)-6 (ni)-2 (a)4 ( \()3 (2.9%)3 ( vs)-1 (. 1.4%)3 (\))3 ( [)-7 (S)-4 (t)-2 (ud)-10 (y)20 ( 2])-7 (\))3 ( w)2 (e)-6 (r)3 (e)4 ( hi)-12 (g)10 (he)4 (r)3 ( i)-2 (n p)-10 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( r)3 (e)4 (c)-6 (e)4 (i)-2 (vi)-2 (ng )]TJ 0.002 Tc -0.002 Tw 0 -1.16 TD [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(a)4 (nd c)4 (he)4 (m)-2 (ot)-12 (he)4 (r)3 (a)4 (p)-20 (y)20 ( c)4 (om)-2 (p)-10 (a)4 (r)3 (e)4 (d )-10 (w)2 (i)-2 (t)-2 (h t)-2 (hos)-1 (e)4 ( r)3 (e)4 (c)-6 (e)4 (i)-2 (vi)-2 (ng c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)-7 (a)-6 (p)-10 (y)20 ( a)4 (l)-2 (on)-10 (e)4 (. T)1 (he)4 ( m)-2 (os)-1 (t )]TJ -5.14 -1.17 Td [(c)4 (om)-2 (m)-2 (on s)-1 (i)-2 (t)-2 (e)4 ( of)3 ( i)-2 (nf)3 (e)4 (c)4 (t)-2 (i)-2 (on)-10 (s)-1 ( i)-2 (n t)-2 (he)4 ( a)4 (dj)-2 (uva)4 (nt)-2 ( s)-1 (e)4 (t)-2 (t)-2 (i)-2 (ng)10 ( i)-12 (nvol)-2 (ve)4 (d t)-2 (he)4 ( uppe)4 (r)3 ( r)-7 (e)4 (s)-1 (pi)-2 (r)3 (a)-6 (t)-2 (or)-7 (y)20 ( t)-2 (r)-7 (a)4 (c)4 (t)-2 (, s)-1 (ki)-2 (n, a)4 (nd )]TJ 0.002 Tc -0.002 Tw 0 -1.17 TD [(u)2 (r)5 (in)2 (a)6 (r)-15 (y)22 ( tr)5 (a)-4 (c)6 (t. )]TJ EMC /P <>BDC 0 Tc 0 Tw 0 -1.66 TD [(I)13 (n S)-4 (t)-2 (ud)-20 (y )20 (4, t)-2 (he)4 ( ove)-6 (r)3 (a)4 (l)-2 (l)-2 ( i)-2 (nc)4 (i)-2 (de)4 (nc)4 (e)4 ( o)-10 (f)3 ( i)-2 (nf)3 (e)-6 (c)4 (t)-2 (i)-2 (on w)2 (a)4 (s )-11 (hi)-2 (g)10 (he)4 (r )-7 (w)2 (i)-2 (t)-2 (h t)-2 (he )4 (a)4 (ddi)-2 (t)-2 (i)-2 (on of )]TJ 0.002 Tc -0.002 Tw 30.85 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(t)-2 (o )]TJ -0.002 Tc 0.002 Tw -35.99 -1.17 Td (AC)Tj 0 Tc 0 Tw 1.39 0 Td [(-)3 (T)1 ( but)-2 ( not)-2 ( t)-2 (o T)1 (C)-3 (H)2 ( [)-7 (4)10 (4%)3 ( \()3 (A)2 (C)-3 (-)]TJ -0.003 Tc 0.003 Tw 11.99 0 Td [(T)-2 (H)-1 (\),)-3 ( 3)-3 (7)-13 (% \(T)-2.1 (C)-6 (H)-11 (\),)-3 ( 3)-3 (8)-3 (% \(A)-1 (C)]TJ 0 Tc 0 Tw 11.22 0 Td [(-)3 (T)-9 (\))3 (])-7 (. T)1 (he)4 ( i)-2 (nc)4 (i)-2 (de)4 (nc)4 (e)4 (s)-1 ( of )-7 (N)2 (C)-13 (I)13 (-)]TJ 0.003 Tc -0.003 Tw 11.52 0 Td [(CT)4 (C )]TJ -0.004 Tc 0.004 Tw -36.12 -1.17 Td [(G)-2 (r)-1 (ad)-4 (e 3)]TJ 0 Tc 0 Tw 3.18 0 Td (\226)Tj 0.002 Tc -0.002 Tw [(4)2 ( in)2 (f)-5 (e)6 (c)6 (tio)2 (n)2 ( w)4 (e)-4 (r)5 (e)-4 ( s)1 (imila)6 (r)5 ( [)-5 (2)2 (5)2 (%)5 ( \()5 (A)4 (C)]TJ 0 Tc 0 Tw 14.43 0 Td (-)Tj -0.003 Tc 0.003 Tw 0.33 0 Td [(T)-2 (H)-1 (\), )-13 (2)-3 (1)-3 (% \(T)-2.1 (C)-6 (H)-1 (\),)-3 ( 2)-3 (3)-3 (% )-10 (\(A)-1 (C)]TJ 0 Tc 0 Tw 11.22 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.33 0 Td [(T)-13 (\))-1 (])-11 ( acr)-1 (o)-4 (s)-5 (s)-5 ( t)-6 (h)-4 (e t)-6 (h)-4 (r)-1 (e)-9.9 (e )]TJ -29.49 -1.17 Td [(ar)-1 (m)-6 (s)-5 (. )]TJ EMC /P <>BDC 0 Tc 0 Tw T* [(I)13 (n )-10 (a)4 ( r)3 (a)4 (ndom)-2 (i)-2 (z)-6 (e)4 (d, c)4 (ont)-2 (r)3 (ol)-2 (l)-12 (e)4 (d t)-2 (r)3 (i)-2 (a)4 (l)-2 ( i)-2 (n t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( of)3 ( m)]TJ -0.004 Tc 0.004 Tw 20.08 0 Td [(et)-6 (as)-5 (t)-6 (at)-6 (i)-6 (c b)-4 (r)-1 (e)-10 (as)-5 (t)-6 ( can)-14 (cer)-0.9 (,)-4 ( t)-6 (h)-14.1 (e r)-0.9 (ep)-4 (o)-4 (r)-1 (t)-16 (ed)-4 ( i)-6 (n)-4 (ci)-6 (d)-4 (en)-4 (c)-10 (e )]TJ 0 Tc 0 Tw -20.08 -1.17 Td [(of)3 ( f)3 (e)4 (br)3 (i)-2 (l)-2 (e)4 ( n)-10 (e)4 (ut)-2 (r)3 (ope)4 (ni)-2 (a )-6 (w)2 (a)-6 (s)-1 ( hi)-2 (g)10 (he)4 (r )-7 (\()3 (23%)3 ( vs)-1 (. 17%)-7 (\))3 ( i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( r)3 (e)4 (c)-6 (e)4 (i)-2 (vi)-2 (ng )]TJ 0.002 Tc -0.002 Tw 28.09 0 Td [(tr)-5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.15 0 Td [(i)-2 (n )]TJ -33.24 -1.17 Td [(c)4 (om)-2 (bi)-2 (na)4 (t)-2 (i)-2 (on w)2 (i)-2 (t)-2 (h m)-12 (y)20 (e)4 (l)-2 (os)-11 (uppr)3 (e)4 (s)-1 (s)-1 (i)-2 (ve)4 ( c)4 (h)-10 (e)4 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y)10 ( a)4 (s)-1 ( c)4 (om)-2 (pa)4 (r)-7 (e)4 (d t)-2 (o c)4 (he)4 (m)-2 (ot)-2 (h)-10 (e)4 (r)3 (a)4 (p)-20 (y)20 ( a)4 (l)-2 (on)-10 (e)4 (. )]TJ EMC /P <>BDC /TT1 1 Tf 0 -2.16 TD [(P)1 (ul)-2 (m)2 (onar)-1 (y)4 ( T)-4 (ox)4 (i)-2 (c)4 (i)-2 (t)-2 (y )]TJ EMC /P <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 0 -1.67 TD [(A)-2 (d)-4 (j)-6 (u)-4 (v)-4 (an)-4 (t)-6 ( B)3 (r)-11 (eas)-5 (t)-6 ( C)-7 (an)-4 (c)-10 (er )]TJ EMC /P <>BDC 0 Tc 0 Tw 0 -1.66 TD [(A)2 (m)-2 (ong)10 ( w)2 (om)-2 (e)4 (n )-10 (r)3 (e)-6 (c)4 (e)4 (i)-2 (vi)-2 (ng a)4 (dj)-2 (uva)4 (nt)-2 ( t)-2 (he)4 (r)3 (a)4 (p)-20 (y )10 (f)3 (or)3 ( br)-7 (e)-6 (a)4 (s)-1 (t)-2 ( c)4 (a)4 (nc)-6 (e)4 (r)3 (, t)-2 (he)4 ( i)-2 (nc)4 (i)-2 (de)4 (n)-10 (c)4 (e )-6 (of)3 ( s)-1 (e)4 (l)-2 (e)4 (c)4 (t)-2 (e)4 (d )-10 (N)2 (C)-13 (I)13 (-)]TJ 0.003 Tc -0.003 Tw 36.67 0 Td [(CT)4 (C )]TJ -0.004 Tc 0.004 Tw -36.67 -1.17 Td [(G)-2 (r)-1 (ad)-4 (e 2)]TJ 0 Tc 0 Tw 3.18 0 Td [(\2265 pul)-2 (m)-2 (ona)-6 (r)-17 (y)20 ( t)-2 (ox)-10 (i)-2 (c)4 (i)-2 (t)-12 (y)30 ( \()3 (14.3%)3 ( vs)-1 (. 5.4)-10 (%)3 ( [)-7 (S)-4 (t)-2 (ud)-10 (y)30 ( 1])-7 (\))3 ( a)4 (nd o)-10 (f)3 ( s)-1 (e)4 (l)-2 (e)-6 (c)4 (t)-2 (e)4 (d)-10 ( N)2 (C)-13 (I)13 (-)]TJ -0.004 Tc 0.004 Tw 28.67 0 Td [(C)-7 (T)-3 (C)-7 ( G)-2 (r)-1 (ad)-4 (e 3)]TJ 0 Tc 0 Tw 5.38 0 Td (\2265 )Tj -37.23 -1.17 Td [(pul)-2 (m)-2 (ona)4 (r)-7 (y)20 ( t)-2 (ox)-10 (i)-2 (c)4 (i)-2 (t)-12 (y)20 ( a)4 (nd s)-11 (pont)-2 (a)4 (ne)4 (ous)-1 ( r)3 (e)4 (po)-10 (r)3 (t)-2 (e)4 (d G)2 (r)-7 (a)-6 (de )4 (2 d)-10 (y)20 (s)-1 (pn)-10 (e)4 (a)4 ( \()3 (3.4)-10 (%)3 ( vs)-1 (. 0)-10 (.9%)3 ( [)-7 (S)-4 (t)-2 (ud)-10 (y)30 ( 2])-7 (\))3 ( w)2 (a)4 (s )]TJ 0.002 Tc -0.002 Tw 0 -1.16 TD [(h)2 (ig)12 (h)2 (e)6 (r)5 ( in)2 ( p)-8 (a)6 (tie)6 (n)2 (ts)1 ( r)5 (e)6 (c)-4 (e)6 (iv)2 (in)2 (g )12 (tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 16.29 0 Td [(a)4 (nd )-10 (c)4 (he)-6 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( c)4 (om)-2 (pa)-6 (r)3 (e)4 (d w)2 (i)-2 (t)-12 (h c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y )10 (a)4 (l)-2 (one)4 (. )]TJ -16.29 -1.17 Td [(T)1 (he)4 ( m)-2 (os)-1 (t)-2 ( c)4 (om)-2 (m)-2 (on pul)-2 (m)-2 (ona)4 (r)-17 (y)20 ( t)-2 (ox)-10 (i)-2 (c)4 (i)-2 (t)-12 (y)30 ( w)-8 (a)4 (s)-1 ( d)-20 (y)20 (s)-1 (pn)-10 (e)4 (a)4 ( \()3 (N)2 (C)-13 (I)13 (-)]TJ -0.004 Tc 0.004 Tw 23.35 0 Td [(C)-7 (T)-3 (C)-7 ( G)-12 (r)-1 (ad)-4 (e 2)]TJ 0 Tc 0 Tw 5.39 0 Td [(\2265:)-12 ( 11.8%)3 ( vs)-1 (. 4.6% )]TJ -28.74 -1.17 Td [([)-7 (S)-4 (t)-2 (ud)-10 (y)30 ( 1])-7 (;)-2 ( N)2 (C)-13 (I)23 (-)]TJ 0.003 Tc -0.003 Tw 6.32 0 Td [(CT)4 (C G)5 (r)-4 (a)-3 (d)3 (e)7 ( 2)]TJ 0 Tc 0 Tw 5.4 0 Td [(\2265:)-2 ( 2.4%)3 ( vs)-1 (. 0.2%)3 ( [)-7 (S)-4 (t)-2 (ud)-10 (y)20 ( 2])-7 (\))3 (. )]TJ EMC /P <>BDC -11.72 -1.66 Td [(P)-4 (ne)4 (um)-2 (oni)-2 (t)-2 (i)-2 (s)-1 (/)-2 (pul)8 (m)-2 (ona)4 (r)-7 (y)20 ( i)-12 (nf)3 (i)-2 (l)-2 (t)-2 (r)3 (a)4 (t)-2 (e)4 (s)-1 ( oc)4 (c)4 (u)-10 (r)3 (r)3 (e)4 (d i)-2 (n 0.7)-10 (%)3 ( of)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( r)3 (e)-6 (c)4 (e)4 (i)-2 (vi)-2 (n)-10 (g )]TJ 0.002 Tc -0.002 Tw 29.46 0 Td [(tr)-5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ -0.004 Tc 0.004 Tw 5.15 0 Td [(co)-4 (m)-6 (p)-4 (ar)-1 (ed )]TJ 0 Tc 0 Tw -34.61 -1.17 Td [(w)2 (i)-2 (t)-2 (h 0.3%)3 ( of)3 ( t)-2 (hos)-1 (e)4 ( r)3 (e)-6 (c)4 (e)4 (i)-12 (vi)-2 (ng)10 ( c)4 (h)-10 (e)4 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y )10 (a)4 (l)-2 (one)-6 (. F)6 (a)4 (t)-2 (a)4 (l)-2 ( r)-7 (e)4 (s)-1 (pi)-2 (r)3 (a)4 (t)-2 (or)-17 (y)20 ( f)-7 (a)4 (i)-2 (l)-2 (ur)3 (e )-6 (oc)4 (c)4 (ur)3 (r)-7 (e)4 (d i)-2 (n 3 )]TJ 0.002 Tc -0.002 Tw [(p)2 (a)6 (tie)6 (n)2 (ts )]TJ -0.004 Tc 0.004 Tw 0 -1.17 TD [(r)-1 (ecei)-6 (v)-4 (i)-6 (n)-14 (g )]TJ 0.002 Tc -0.002 Tw 3.96 0 Td [(tr)-5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b)]TJ 0 Tc 0 Tw 4.9 0 Td [(, one)4 ( a)4 (s)-1 ( a)4 ( c)4 (om)-2 (pon)-10 (e)4 (nt)-2 ( of)3 ( m)-2 (u)-10 (l)-2 (t)-2 (i)-2 (-)]TJ -0.004 Tc 0.004 Tw 12.2 0 Td [(o)-4 (r)-1 (g)6 (an)-4 ( s)-25 (y)16 (s)-5 (t)-6 (em)-6 ( f)-11 (ai)-6 (l)-6 (u)-4 (r)-1 (e, )-14 (as)-5 ( co)-4 (m)-6 (p)-4 (ar)-11 (ed)-4 ( t)-6 (o )]TJ 0 Tc 0 Tw -21.06 -1.17 Td (1 )Tj -0.004 Tc 0.004 Tw [(p)-4 (at)-6 (i)-6 (en)-4 (t)-6 ( r)-1 (ec)-10 (ei)-6 (v)-4 (i)-6 (n)-4 (g )-4 (ch)-4 (em)-16 (o)-3.9 (t)-6.1 (h)-4 (er)-0.9 (ap)-24 (y)16 ( al)-6 (o)-4 (n)-4 (e. )]TJ EMC /Span <>BDC 0 -2.16 TD [(M)-5 (et)-6 (as)-5 (t)-6 (at)-6 (i)-6 (c B)-7 (r)-1 (eas)-5 (t)-6 ( C)-7 (an)-14 (cer )]TJ EMC /Artifact <>BDC 0 Tc 0 Tw 19 -4.5 Td (16)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 31.3727 26.9686 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4660 0 obj <>>>/Resources 4520 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4661 0 obj <> endobj 4662 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
 endstream endobj 4663 0 obj <> endobj 4664 0 obj <>stream q 1 0 0 1 21.829681 16.838623 cm 0 0 612 792 re W n 1 0 0 1 -21.829681 -16.838623 cm BT /Artifact <>BDC /CS0 cs 0 scn /TT0 1 Tf 3 Tr 12 0 0 12 93.8297 55.4786 Tm ( )Tj 20 0 Td ( )Tj 19 0 Td ( )Tj /TT1 1 Tf -36.18 55.83 Td [( )-850 ( )]TJ 7.89 -1.16 Td ( )Tj 14.91 0 Td [( )-2000 ( )]TJ -9.95 -1.17 Td ( )Tj /TT0 1 Tf 22.87 -20.72 Td ( )Tj -23.76 -1.45 Td ( )Tj 0.002 Tc -0.002 Tw 22.71 -1.66 Td ( )Tj -0.004 Tc 0.004 Tw -28.2 -1.17 Td ( )Tj 24.65 0 Td ( )Tj -0.002 Tc 0.002 Tw -20.23 -1.17 Td ( )Tj -0.004 Tc 0.004 Tw 11.96 0 Td ( )Tj 0 Tc 0 Tw 10.72 0 Td ( )Tj -0.004 Tc 0.004 Tw -16.77 -1.16 Td ( )Tj 0.002 Tc -0.002 Tw 18.52 0 Td ( )Tj 0 Tc 0 Tw -27.64 -1.17 Td ( )Tj 5.29 0 Td ( )Tj 8.32 0 Td ( )Tj -16.64 -2.17 Td ( )Tj 0.002 Tc -0.002 Tw 4.25 -1.66 Td ( )Tj 0 Tc 0 Tw 17.94 0 Td ( )Tj 5.77 0 Td [( )-2180 ( )]TJ 0.002 Tc -0.002 Tw 2.64 -1.17 Td ( )Tj 0 Tc 0 Tw 0.3 -1.17 Td ( )Tj -33.48 -1.16 Td ( )Tj 16.1 0 Td [( )-4890 ( )]TJ 15.74 0 Td ( )Tj -31.57 -1.17 Td [( )-1340 ( )]TJ 0.66 -1.17 Td ( )Tj 32.05 -1.16 Td ( )Tj -27.6 -1.17 Td ( )Tj 13.66 0 Td [( )-4890 ( )]TJ 5.85 -1.17 Td ( )Tj 0.002 Tc -0.002 Tw 6.3 0 Td ( )Tj 0 Tc 0 Tw -22.73 -1.16 Td ( )Tj 16.2 0 Td ( )Tj -23.83 -1.17 Td ( )Tj -2.67 -2.17 Td ( )Tj 22.4 -1.66 Td ( )Tj 11.95 0 Td ( )Tj -2.23 -1.17 Td ( )Tj -21.62 -1.17 Td ( )Tj -0.004 Tc 0.004 Tw 6.27 0 Td ( )Tj 15.99 0 Td ( )Tj EMC /P <>BDC /TT1 1 Tf -0.011 Tc 0.011 Tw 0 Tr -35.81 52.5 Td [(Fi)-13 (g)-11 (u)-15 (r)-7 (e )]TJ 0 Tc 0 Tw 3.07 0 Td [(2)-10 (:)]TJ /T1_0 1 Tf (\003 )Tj /C2_0 1 Tf 2.93 0 Td [<0036>-4 <0057>3 <0058>-4 <0047>-4 <005C00030017001D>3 <00030026>2 <0058>-4 <0050>13 <0058>-4 <004F>-2 <00440057>3 <004C>-2 <00590048>4 <0003002C>-1 <0051>-4 <0046>4 <004C>-2 <0047>-4 <0048>4 <0051>-4 <0046>4 <0048>4 <000300520049>-7 <00030037>-3 <004C>-2 <0050>13 <0048>4 <00030057>3 <00520003>-10 <0029>11 <004C>-12 <0055>4 <0056>-1 <0057>-7 <0003002F>-3 <0039>2 <0028>-3 <0029>11 <00030027>2 <0048>-6 <0046>4 <004F>-2 <004C>-2 <0051>-4 <0048>4 <000300520049>-7 <00030095>-1 <0003001400130003>]TJ /TT1 1 Tf 0 -1.16 TD [(P)11 (e)-6 (r)4 (c)-6 (e)4 (n)-4 (t)3 (age )-6 (P)11 (oi)-2 (n)-4 (t)3 (s)-1 ( f)-7 (r)4 (o)-10 (m)3 ( B)-3 (as)-1 (e)4 (l)-2 (i)-2 (n)-4 (e)4 ( an)-4 (d)-4 ( t)3 (o B)-3 (e)4 (l)-2 (o)10 (w )2 (50% w)-8 (i)-2 (t)3 (h)-4 ( D)2 (e)4 (at)3 (h)-4 ( as)-1 ( a )]TJ 0.004 Tc -0.004 Tw 0 -1.17 TD [(C)6 (o)-6 (m)17 (pe)8 (t)7 (i)2 (ng)4 ( R)6 (i)2 (s)3 (k E)1 (v)4 (e)8 (nt )]TJ EMC ET /Figure <>BDC /ClipSpan BMC q /Clip BMC 1 0 0 1 21.829681 16.838623 cm 72 672 462.55 -239.6 re W n EMC q /GS0 gs 462.5500005 0 0 239.5999969 72 432.4000031 cm /Im0 Do Q EMC EMC Q BT /P <>BDC /TT0 1 Tf 0 Tc 0 Tw 12 0 0 12 93.8297 431.4386 Tm [(T)1 (i)-2 (m)-2 (e)4 ( 0 i)-2 (s)-1 ( t)-2 (he)4 ( da)4 (t)-2 (e)4 ( of)3 ( r)-7 (a)4 (n)-10 (dom)-2 (i)-2 (z)-6 (a)4 (t)-2 (i)-2 (on. )]TJ EMC /P <>BDC 0.002 Tc -0.002 Tw 0 -1.66 TD [(T)3 (h)2 (e)6 ( in)2 (c)6 (id)2 (e)6 (n)2 (c)-4 (e)6 ( o)2 (f)5 ( tr)5 (e)-4 (a)6 (tme)-4 (n)2 (t e)6 (me)6 (r)-5 (g)12 (e)6 (n)2 (t c)6 (o)2 (n)-8 (g)2 (e)6 (s)0.9 (tiv)2.1 (e)5.9 ( h)-8 (e)6 (a)6 (r)5.1 (t f)-4.9 (a)6 (ilu)1.9 (r)5 (e)6 ( a)6 (mo)2 (n)-8 (g)12 ( p)2 (a)6 (tie)6 (n)-8 (ts)1 ( in)2 ( th)2 (e)6 ( me)6 (ta)6 (s)1 (ta)6 (tic )]TJ -0.004 Tc 0.004 Tw 0 -1.17 TD [(b)-4 (r)-1 (eas)-5 (t)-6 ( c)-10 (an)-4 (ce)-10 (r)-1 ( t)-6 (r)-1 (i)-6 (al)-6 (s)-5 ( w)-2 (as )-14.9 (c)-10 (l)-6.1 (as)-4.9 (s)-5 (i)-6 (f)-1 (i)-6 (ed)-4 ( f)-1 (o)-4 (r)-1 ( s)-5 (ev)-14 (er)-1 (i)-6 (t)-16 (y)16 ( u)-4 (s)-5 (i)-6 (n)-14 (g)6 ( t)-6 (h)-4 (e N)-12 (ew)-2 ( Y)-2 (o)-14 (r)-1 (k)-4 ( H)-2 (e)-10 (ar)-1 (t)-6 ( A)-12 (s)-4.9 (s)-5.1 (o)-3.9 (ci)-6.1 (at)-5.9 (i)-6 (o)-4 (n )]TJ 0.002 Tc -0.002 Tw T* [(c)6 (la)6 (s)1 (s)1 (if)5 (ic)6 (a)6 (tio)2 (n)2 ( s)-19 (y)32 (s)1 (t)-10 (e)6 (m \()-5 (I)]TJ 0 Tc 0 Tw 9.21 0 Td (\226)Tj -0.002 Tc 0.002 Tw 0.51 0 Td [(I)1 (V,)-2 ( wh)-2 (e)2 (r)-9 (e )-8 (I)11 (V )]TJ -0.004 Tc 0.004 Tw [(i)-6 (s)-5 ( t)-6 (h)-4 (e m)-6 (o)-4 (s)-5 (t)-6 ( s)-5 (ev)-4 (er)-1 (e l)-16 (ev)-3.9 (el)-6 ( o)-4 (f )-11 (car)-1 (d)-4 (i)-6 (a)-10 (c f)-1 (ai)-6 (l)-16 (u)-4 (r)-1 (e\))-1 ( \()-1 (s)-15 (ee T)-3 (ab)-4 (l)-16 (e )]TJ 0 Tc 0 Tw (2)Tj 0.01 Tw [(\))3 (. I)13 (n )]TJ -0.004 Tc 0.004 Tw -9.72 -1.16 Td [(t)-6 (h)-4 (e m)-6 (et)-6 (as)-5 (t)-6 (at)-6 (i)-6 (c b)-4 (r)-1 (e)-9.9 (as)-5 (t)-6 ( can)-14 (cer)-1 ( t)-6 (r)-1 (i)-6 (al)-6 (s)-5 (,)-4 ( t)-6 (h)-4 (e p)-14 (r)-1 (o)-4 (b)-4 (ab)-4 (i)-6 (l)-6 (i)-6 (t)-16 (y )6 (o)-4 (f)-1 ( car)-1 (d)-4 (i)-16 (ac d)-24 (y)16 (s)-5 (f)-1 (u)-4 (n)-14 (c)]TJ 0.002 Tc -0.002 Tw [(tio)2 (n)2 ( w)4 (a)6 (s)1 ( h)2 (ig)12 (h)2 (e)6 (s)1 (t in)2 ( p)2 (a)6 (tie)6 (n)2 (ts )]TJ 0 Tc 0 Tw T* [(w)2 (ho r)3 (e)4 (c)-6 (e)4 (i)-2 (ve)4 (d )]TJ 0.002 Tc -0.002 Tw [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)-4 (b )]TJ 0 Tc 0 Tw 10.75 0 Td [(c)4 (onc)4 (ur)3 (r)-7 (e)4 (nt)-2 (l)-12 (y )10 (w)2 (i)-2 (t)-2 (h a)4 (nt)-2 (hr)-7 (a)4 (c)-16 (y)20 (c)4 (l)-2 (i)-2 (ne)4 (s)-1 (. )]TJ EMC /P <>BDC /TT2 1 Tf -10.75 -2.17 Td [(I)3 (nf)-2 (us)-1 (i)-2 (on R)1 (e)4 (ac)4 (t)-2 (i)-2 (ons )]TJ EMC /P <>BDC /TT0 1 Tf 0.002 Tc -0.002 Tw 0 -1.66 TD [(D)4 (u)2 (r)5 (in)2 (g)12 ( th)-8 (e)6 ( f)5 (ir)5 (s)1 (t in)2 (f)5 (u)2 (s)1 (io)2 (n)2 ( w)4 (ith )2 (tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b)]TJ 0 Tc 0 Tw 16.86 0 Td [(, t)-2 (he)4 ( s)-11 (y)10 (m)-2 (pt)-2 (om)-2 (s)-1 ( m)-2 (os)-1 (t)-2 ( c)4 (om)-2 (m)-2 (onl)-12 (y )20 (r)3 (e)4 (por)3 (t)-2 (e)4 (d w)-8 (e)4 (r)3 (e )-6 (c)4 (hi)-2 (l)-2 (l)-2 (s )]TJ -16.86 -1.17 Td [(a)4 (nd f)3 (e)4 (ve)-6 (r)3 (, oc)-6 (c)4 (ur)3 (r)3 (i)-2 (n)-10 (g)10 ( i)-2 (n a)-6 (ppr)3 (ox)-10 (i)-2 (m)-2 (a)4 (t)-2 (e)4 (l)-12 (y)30 ( 40)-10 (%)3 ( of)3 ( pa)4 (t)-12 (i)-2 (e)4 (nt)-2 (s)-1 ( i)-2 (n )]TJ 0.002 Tc -0.002 Tw [(c)6 (lin)2 (ic)6 (a)6 (l tr)5 (ia)6 (ls)1 (.)2 ( S)-12 (y)12 (mp)2 (to)2 (ms)1 ( w)4 (e)6 (r)5 (e)6 ( tr)5 (e)6 (a)6 (t)-10 (e)6 (d )]TJ 0 Tc 0 Tw 0 -1.17 TD [(w)2 (i)-2 (t)-2 (h a)4 (c)4 (e)4 (t)-2 (a)4 (m)-2 (i)-2 (nophe)4 (n, di)-2 (p)-10 (he)4 (nh)-10 (y)20 (d)-10 (r)3 (a)4 (m)-2 (i)-2 (ne)4 (, a)4 (nd m)-12 (e)4 (pe)-6 (r)3 (i)-2 (di)-2 (ne)4 ( \()3 (w)2 (i)-2 (t)-2 (h or)3 ( w)2 (i)-2 (t)-2 (hout)-2 ( r)3 (e)-6 (duc)4 (t)-2 (i)-2 (on i)-2 (n t)-2 (he)4 ( r)3 (a)4 (t)-2 (e)4 ( of )]TJ 0.002 Tc -0.002 Tw 0 -1.16 TD [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(i)-2 (nf)3 (us)-1 (i)-2 (on\))3 (;)-2 ( pe)4 (r)3 (m)-2 (a)4 (ne)4 (nt)-2 ( di)-2 (s)-1 (c)4 (ont)-2 (i)-2 (nua)4 (t)-2 (i)-2 (on of )]TJ 0.002 Tc -0.002 Tw 16.1 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(f)3 (or)3 ( i)-2 (nf)3 (us)-1 (i)-2 (on r)3 (e)4 (a)4 (c)4 (t)-2 (i)-2 (ons)-1 ( w)-8 (a)4 (s )]TJ -26.38 -1.17 Td [(r)3 (e)4 (qui)-2 (r)3 (e)4 (d i)-2 (n < )]TJ 0.01 Tc -0.01 Tw 5.41 0 Td (1% )Tj 0 Tc 0 Tw 1.59 0 Td [(of)3 ( pa)4 (t)-2 (i)-2 (e)-6 (nt)-2 (s)-1 (. O)2 (t)-2 (he)4 (r)3 ( s)-1 (i)-2 (g)10 (ns)-1 ( a)4 (nd/)-2 (o)-10 (r)3 ( s)-11 (y)10 (m)-2 (pt)-2 (om)-2 (s)-1 ( m)-2 (a)-6 (y)30 ( i)-2 (n)-10 (c)4 (l)-2 (ude)4 ( na)4 (u)-10 (s)-1 (e)4 (a)4 (, vom)-2 (i)-2 (t)-2 (i)-2 (ng)10 (, pa)4 (i)-2 (n )]TJ -7 -1.17 Td [(\()3 (i)-2 (n s)-1 (om)-2 (e)4 ( c)4 (a)4 (s)-1 (e)4 (s )-11 (a)4 (t)-2 ( t)-2 (um)-2 (or)3 ( s)-1 (i)-2 (t)-2 (e)4 (s)-1 (\))3 (, r)3 (i)-2 (g)10 (o)-10 (r)3 (s)-1 (, he)4 (a)4 (d)-10 (a)4 (c)4 (he)4 (, di)-12 (z)-6 (z)-6 (i)-2 (ne)4 (s)-1 (s)-1 (, d)-10 (y)30 (s)-1 (pne)-6 (a)4 (, h)-20 (y)20 (pot)-2 (e)-6 (ns)-1 (i)-2 (on, e)4 (l)-2 (e)4 (va)4 (t)-2 (e)4 (d bl)-2 (ood )]TJ T* [(pr)3 (e)4 (s)-1 (s)-1 (ur)3 (e)4 (, )-10 (r)3 (a)4 (s)-1 (h, a)4 (nd )-10 (a)4 (s)-1 (t)-2 (he)-6 (ni)-2 (a)4 (. )-10 (I)23 (n)-10 (f)3 (us)-1 (i)-2 (on r)3 (e)-6 (a)4 (c)4 (t)-2 (i)-2 (ons)-1 ( oc)-6 (c)4 (ur)3 (r)3 (e)4 (d i)-2 (n 21%)-7 ( a)4 (nd 35%)3 ( o)-10 (f)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 (, a)4 (nd w)2 (e)-6 (r)3 (e )]TJ 0.001 Tc -0.001 Tw 0 -1.17 TD (se)Tj 0 Tc 0 Tw 0.83 0 Td [(ve)4 (r)3 (e)4 ( i)-2 (n 1.4)-10 (%)3 ( a)4 (nd 9%)3 ( o)-10 (f )3 (pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 (, on s)-1 (e)4 (c)4 (ond or)3 ( s)-11 (ubs)-1 (e)4 (que)4 (nt )]TJ 0.002 Tc -0.002 Tw 23.35 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(i)-2 (nf)3 (us)-1 (i)-2 (ons)-1 ( a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d )]TJ -29.32 -1.17 Td [(a)4 (s)-1 ( m)-2 (onot)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( or)3 ( i)-2 (n c)4 (o)-10 (m)-2 (bi)-2 (na)4 (t)-2 (i)-2 (on w)2 (i)-2 (t)-2 (h c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 (, r)3 (e)4 (s)-1 (p)-10 (e)4 (c)4 (t)-2 (i)-2 (ve)4 (l)-22 (y)20 (. )-10 (I)13 (n t)-2 (he )-6 (pos)-1 (t)-2 (-)]TJ 0.002 Tc -0.002 Tw 32.04 0 Td [(ma)6 (r)5 (k)2 (e)6 (tin)2 (g )]TJ 0 Tc 0 Tw -32.04 -1.16 Td [(s)-1 (e)4 (t)-2 (t)-2 (i)-2 (ng)10 (, s)-1 (e)4 (ve)-6 (r)3 (e)4 ( i)-2 (nf)3 (us)-1 (i)-2 (on r)-7 (e)4 (a)4 (c)4 (t)-2 (i)-2 (ons)-1 (, i)-2 (nc)4 (l)-2 (udi)-2 (ng)10 ( h)-20 (y)20 (p)-10 (e)4 (r)-7 (s)-1 (e)4 (ns)-1 (i)-2 (t)-2 (i)-2 (vi)-2 (t)-12 (y)30 (, )-10 (a)4 (na)4 (ph)-20 (y)20 (l)-2 (a)4 (x)-10 (i)-2 (s)-1 (, )]TJ -0.004 Tc 0.004 Tw [(an)-4 (d)-4 ( an)-14 (g)6 (i)-6 (o)-4 (ed)-4 (em)-16 (a h)-4 (av)-4 (e )]TJ T* [(b)-4 (een)-4 ( r)-1 (ep)-4 (o)-14 (r)-1 (t)-6 (ed)-4 (. )]TJ EMC /P <>BDC /TT2 1 Tf 0 -2.17 TD [(A)-3 (n)-4 (em)-2 (i)-6 (a )]TJ EMC /Span <>BDC /TT0 1 Tf 0 Tc 0 Tw 0 -1.66 TD [(I)13 (n )-10 (r)3 (a)4 (ndom)-2 (i)-2 (z)-6 (e)4 (d c)4 (ont)-2 (r)3 (ol)-2 (l)-2 (e)4 (d)-10 ( c)4 (l)-2 (i)-2 (ni)-2 (c)4 (a)4 (l)-2 ( t)-2 (r)3 (i)-2 (a)4 (l)-2 (s)-1 (, t)-2 (he)4 ( ove)4 (r)-7 (a)4 (l)-2 (l)-2 ( i)-2 (nc)4 (i)-2 (de)4 (nc)4 (e)4 ( of )-7 (a)4 (ne)4 (m)-2 (i)-2 (a)4 ( \()-7 (30)-10 (%)3 ( vs)-1 (. 21%)3 ( [)-7 (S)-4 (t)-2 (ud)-10 (y )]TJ -0.004 Tc 0.004 Tw 0 -1.17 TD [(5)-4 (])-11 (\))-1 (,)-4 ( o)-4 (f)-1 ( s)-5 (el)-6 (ect)-6 (ed)-4 ( N)-2 (C)-17 (I)]TJ 0 Tc 0 Tw 7.93 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.33 0 Td [(C)-7 (T)-3 (C)-17 ( G)-2 (r)-1 (ad)-4 (e 2)]TJ 0 Tc 0 Tw 5.39 0 Td [(\2265 )-10 (a)4 (ne)4 (m)-2 (i)-2 (a)4 ( \()3 (12.3)-10 (%)3 ( vs)-1 (. 6.7%)3 ( [)-7 (S)-4 (t)-2 (ud)-10 (y)30 ( 1])-7 (\))3 (, a)-6 (nd of)3 ( a)4 (ne)4 (m)-2 (i)-2 (a )]TJ -13.65 -1.17 Td [(r)3 (e)4 (qui)-2 (r)3 (i)-2 (n)-10 (g)10 ( t)-2 (r)3 (a)4 (ns)-1 (f)3 (us)-1 (i)-2 (ons)-1 ( \()3 (0.)-10 (1%)3 ( vs)-1 (. 0 )]TJ -0.004 Tc 0.004 Tw [(p)-4 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( [)-11 (S)-8 (t)-6 (u)-4 (d)-14 (y )16 (2)-4 (])-11 (\))-1 ( w)-2 (er)-1 (e i)-6.1 (n)-3.9 (cr)-11 (eas)-5 (ed)-4 ( i)-6 (n)-4 ( p)-14 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( r)-1 (ec)-10 (ei)-6 (v)-4 (i)-6 (n)-4 (g )]TJ EMC /Artifact <>BDC 0 Tc 0 Tw 19 -3.33 Td (15)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 31.8297 26.8386 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS1 gs /Fm0 Do Q EMC endstream endobj 4665 0 obj <>>>/Resources 4519 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4666 0 obj <> endobj 4667 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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o)-13.9 (f)-1 ( at)-6 ( l)-6 (eas)-5 (t )]TJ -22.35 -1.17 Td [(2)-4 (%)-1 ( g)-4 (r)-1 (eat)-16 (er)-1 ( am)-6 (o)-4 (n)-14 (g)6 ( p)-4 (at)-6 (i)-6 (en)-14 (t)-6 (s)-4.9 ( r)-1 (ecei)-6 (v)-4 (i)-6 (n)-14 (g )]TJ 0.002 Tc -0.002 Tw 14.9 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ -0.004 Tc 0.004 Tw 5.15 0 Td [(p)-4 (l)-6 (u)-4 (s)-5 ( ch)-4 (em)-6 (o)-4 (t)-6 (h)-4 (er)-1 (ap)-24 (y )6 (as)-5 ( co)-14 (m)-6 (p)-4 (ar)-0.9 (ed)-4 ( t)-6 (o )]TJ 0 Tc 0 Tw -20.05 -1.16 Td [(c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y )10 (a)4 (l)-2 (one)4 (:)-2 ( f)-7 (a)4 (t)-2 (i)-2 (g)10 (ue )-6 (\()3 (29.5%)3 ( vs)-1 (. 22.4%)-7 (\))3 (, i)-2 (nf)3 (e)4 (c)4 (t)-2 (i)-2 (on \()3 (24.0%)3 ( vs)-1 (. 12.8)-10 (%)3 (\))3 (, hot)-2 ( f)3 (l)-2 (a)4 (s)-1 (he)4 (s)-1 ( \()3 (17.1)-10 (% )]TJ 0 -1.17 TD [(vs)-1 (. 15.0%)3 (\))3 (, a)4 (ne)4 (m)-2 (i)-2 (a )-6 (\()3 (12.3)-10 (%)3 ( vs)-1 (. 6.7%)3 (\))3 (, d)-20 (y)20 (s)-1 (pne)-6 (a)4 ( \()3 (1)-10 (1.8%)3 ( vs)-1 (. 4.6%)3 (\))3 (, r)-7 (a)4 (s)-1 (h/)-2 (de)4 (s)-11 (qua)4 (m)-2 (a)4 (t)-2 (i)-2 (on \()3 (10.9%)3 ( vs)-1 (. )]TJ T* [(7.6%)3 (\))3 (, l)-2 (e)4 (ukope)4 (ni)-2 (a )-6 (\()3 (10.5)-10 (%)3 ( vs)-1 (. 8.4%)3 (\))3 (, ne)4 (ut)-2 (r)3 (op)-10 (e)4 (ni)-2 (a)-6 ( \()3 (6.4%)3 ( vs)-1 (. 4.3%)3 (\))3 (, h)-10 (e)4 (a)4 (da)-6 (c)-6 (he)4 ( \()3 (6.2%)3 ( vs)-1 (. 3.8%)-7 (\))3 (, )]TJ 0 -1.16 TD [(pa)4 (i)-2 (n \()3 (5.5%)3 ( vs)-1 (. 3.0%)3 (\))3 (, )-10 (e)4 (d)-10 (e)4 (m)-2 (a)4 ( \()3 (4.7%)3 ( vs)-1 (. 2.7%)-7 (\))3 ( a)4 (nd)-10 ( i)-2 (ns)-1 (om)-2 (ni)-2 (a)4 ( \()3 (4.3%)3 ( vs)-1 (. 1.5%)3 (\))3 (. T)1 (he)4 ( m)-2 (a)4 (j)-2 (or)3 (i)-2 (t)-22 (y)20 ( of )]TJ -0.004 Tc 0.004 Tw 0 -1.17 TD [(t)-6 (h)-4 (es)-5 (e ev)-4 (en)-4 (t)-6 (s)-5 ( w)-12 (er)-1 (e )-10 (G)-2 (r)-1 (ad)-14 (e )-10 (2)-3.9 ( i)-6.1 (n)-3.9 ( s)-5.1 (ev)-3.9 (er)-1 (i)-6 (t)-16 (y)16 (. )]TJ EMC /P <>BDC 0.002 Tc -0.002 Tw 0 -1.67 TD [(I)15 (n)2 ( S)-2 (tu)2 (d)-18 (y)22 ( 2)2 (,)2 ( d)2 (a)6 (ta )-4 (c)6 (o)2 (lle)6 (c)6 (tio)-8 (n)2 ( w)4 (a)6 (s)1 ( limite)6 (d)2 ( to)2 ( th)2 (e)6 ( f)5 (o)2 (llo)2 (w)3.9 (in)2 (g)11.9 ( in)2 (v)2 (e)5.9 (s)1 (ti)-10 (g)12 (a)6 (to)2 (r)]TJ 0 Tc 0 Tw 27.02 0 Td (-)Tj 0.002 Tc -0.002 Tw 0.34 0 Td [(a)6 (ttr)5 (ib)2 (u)2 (te)6 (d)2 ( tr)5 (e)6 (a)6 (tme)6 (n)2 (t)]TJ 0 Tc 0 Tw (-)Tj -0.004 Tc 0.004 Tw 8.19 0 Td [(r)-1 (el)-6 (at)-6 (ed )]TJ -35.55 -1.16 Td [(ad)-4 (v)-4 (er)-1 (s)-5 (e )-10 (r)-1 (ea)-10 (ct)-6 (i)-6 (o)-4 (n)-4 (s)-5 (:)-6 ( N)-2 (C)-17 (I)]TJ 0 Tc 0 Tw 9.16 0 Td [(-)3 (C)-3 (T)1 (C)-3 ( G)2 (r)3 (a)4 (de)4 ( 4 a)-6 (nd 5 he)4 (m)-2 (a)4 (t)-12 (ol)-2 (og)10 (i)-2 (c)4 ( t)-2 (ox)-10 (i)-2 (c)4 (i)-2 (t)-2 (i)-2 (e)4 (s)-1 (, G)2 (r)3 (a)4 (de)4 ( 3)-10 (\2265 non-)]TJ -0.004 Tc 0.004 Tw 24.05 0 Td [(h)-4 (em)-6 (at)-6 (o)-4 (l)-6 (o)-4 (g)6 (i)-16 (c )]TJ -33.21 -1.17 Td [(t)-6 (o)-4 (x)-14 (i)-6 (ci)-6 (t)4 (i)-6 (es)-5 (,)-4 ( s)-5 (el)-6 (ect)-6 (ed)-4 ( G)-2 (r)-10.9 (ad)-4 (e)-9.9 ( 2)]TJ 0 Tc 0 Tw 10.83 0 Td (\2265 t)Tj -0.004 Tc 0.004 Tw 1.53 0 Td [(o)-4 (x)-14 (i)-6 (ci)-6 (t)4 (i)-6 (es)-5 ( as)-5 (s)-5 (o)-4 (ci)-6 (at)-6 (ed)-14 ( w)-2 (i)-6 (t)-5.9 (h)-4 ( t)-6.1 (ax)-13.9 (an)-4 (es)-5 ( \()-1 (m)-16 (y)16 (al)-16 (g)6 (i)-6 (a, )-14 (a)-10 (r)-1 (t)-6 (h)-4 (r)-1 (al)-16 (g)6 (i)-6 (as)-5 (,)-4 ( n)-4 (ai)-6 (l )]TJ 0 Tc 0 Tw -12.36 -1.17 Td [(c)4 (ha)4 (n)-10 (g)10 (e)4 (s)-1 (, m)-2 (ot)-2 (or)3 ( ne)4 (u)-10 (r)3 (opa)4 (t)-12 (h)-10 (y)20 (, s)-1 (e)4 (ns)-1 (o)-10 (r)-17 (y)20 ( ne)4 (ur)3 (op)-10 (a)4 (t)-2 (h)-10 (y)20 (\) )-17 (a)4 (nd G)2 (r)3 (a)4 (d)-10 (e)4 ( 1\226)]TJ -0.004 Tc 0.004 Tw [(5)-4 ( ca)-10 (r)-1 (d)-4 (i)-6 (ac t)-6 (o)-14 (x)-14 (i)-6 (ci)-6 (t)-6 (i)-6 (es)-5 ( o)-4 (ccu)-4 (r)-1 (r)-1 (i)-6.1 (n)-3.9 (g )]TJ 0 Tc 0 Tw 0 -1.16 TD [(dur)3 (i)-2 (ng)10 ( c)4 (h)-10 (e)4 (m)-2 (ot)-2 (he)4 (r)-7 (a)4 (p)-20 (y)20 ( a)4 (nd)-10 (/)-2 (or )]TJ 0.002 Tc -0.002 Tw 11.58 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (n)-10 (t)-2 (. T)1 (he)4 ( f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng)10 ( non-)]TJ -0.004 Tc 0.004 Tw 12.05 0 Td [(ca)-10 (r)-11 (d)-4 (i)-6 (ac ad)-4 (v)-4 (e)-10 (r)-1 (s)-5 (e r)-11 (eact)-6 (i)-6 (o)-3.9 (n)-4 (s )]TJ -28.77 -1.17 Td [(o)-4 (f)-1 ( G)-2 (r)-1 (ad)-14 (e 2)]TJ 0 Tc 0 Tw 4.27 0 Td (\226)Tj -0.004 Tc 0.004 Tw [(5)-4 ( o)-4 (ccu)-14 (r)-1 (r)-1 (ed )-14 (at)-16 ( an)-4 ( i)-6 (n)-4 (ci)-6 (d)-4 (en)-4 (c)-9.9 (e o)-4 (f)-1 ( at)-6 ( l)-6 (e)-10 (as)-5 (t)-6 ( 2)-4 (%)-1 ( g)-4 (r)-1 (eat)-16 (er)-1 ( am)-6 (o)-4 (n)-14 (g)6 ( p)-4 (at)-6 (i)-6 (en)-4 (t)-6 (s)-15 ( r)-1 (ecei)-6 (v)-4 (i)-6 (n)-14 (g )]TJ 0.002 Tc -0.002 Tw -4.27 -1.17 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(pl)-2 (us)-1 ( c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( a)4 (s )-11 (c)4 (om)-2 (pa)4 (r)-7 (e)4 (d t)-2 (o c)4 (h)-10 (e)4 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( a)4 (l)-2 (on)-10 (e)4 (:)-2 ( a)4 (r)3 (t)-2 (hr)-7 (a)-6 (l)-2 (g)10 (i)-2 (a)4 ( \()3 (12.2)-10 (%)3 ( vs)-1 (. )]TJ -5.14 -1.16 Td [(9.1%)3 (\))3 (, na)4 (i)-2 (l)-2 ( c)4 (ha)4 (n)-10 (ge)4 (s)-1 ( \()3 (11.5)-10 (% )3 (vs)-1 (. 6.8%)3 (\))3 (, d)-20 (y)20 (s)-1 (pne)-6 (a)4 ( \()3 (2.)-10 (4%)3 ( vs)-1 (. 0.2%)3 (\))3 (, a)4 (nd di)-2 (a)-6 (r)3 (r)3 (h)-10 (e)4 (a)4 ( \()3 (2.2%)3 ( vs)-1 (. 0)-10 (%)3 (\))3 (. )]TJ -0.001 Tc 0.001 Tw 0 -1.17 TD (Th)Tj -0.004 Tc 0.004 Tw 1.11 0 Td [(e m)-6 (aj)-6 (o)-4 (r)-1 (i)-6 (t)-16 (y)16 ( o)-14 (f)-1 ( t)-6 (h)-4 (es)-5 (e )-10 (ev)-4 (e)-10 (n)-4 (t)-6 (s)-4.9 ( w)-2.1 (er)-0.9 (e G)-12 (r)-1 (ad)-4 (e 2)-4 ( i)-6 (n)-4 ( s)-5 (ev)-14 (er)-11 (i)-6 (t)-16 (y)16 (. )]TJ EMC /P <>BDC -1.11 -1.67 Td [(S)-8 (af)-1 (et)-16 (y)16 ( d)-14 (at)-6 (a f)-11 (r)-1 (o)-4 (m)-6 ( S)-8 (t)-6 (u)-4 (d)-14 (y )16 (4)-14 ( r)-0.9 (ef)-1.1 (l)-6 (e)-10 (ct)-6 ( ex)-14 (p)-3.9 (o)-4.1 (s)-5 (u)-4 (r)-1 (e t)-6 (o )]TJ 0.002 Tc -0.002 Tw 17.94 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ -0.004 Tc 0.004 Tw 5.14 0 Td [(as)-5 ( p)-4 (ar)-1 (t)-6 ( o)-4 (f)-1 ( an)-4 ( ad)-4 (j)-6 (u)-14 (v)-4 (an)-4 (t)-6 ( t)-6 (r)-1 (eat)-5.9 (m)-6.1 (en)-3.9 (t )]TJ 0 Tc 0 Tw -23.08 -1.16 Td [(r)3 (e)-6 (g)10 (i)-2 (m)-2 (e)4 (n f)3 (r)3 (om)-2 ( 2124 )]TJ 0.002 Tc -0.002 Tw [(p)2 (a)6 (tie)-4 (n)2 (ts)1 ( r)5 (e)6 (c)6 (e)6 (iv)2 (in)-8 (g)12 ( a)6 (t le)-4 (a)6 (s)1 (t o)2 (n)2 (e )-4 (d)2 (o)2 (s)1 (e)6 ( o)2 (f)5 ( s)1 (tu)2 (d)-8 (y)22 ( tr)-5 (e)5.9 (a)6 (tme)5.9 (n)2.1 (t [)-5 (A)3.9 (C)]TJ 0 Tc 0 Tw 31.38 0 Td [(-)3 (T)1 (H)2 (:)-2 ( n =)4 ( 1068; )]TJ -31.38 -1.17 Td [(T)1 (C)-3 (H)2 (:)-2 ( n =)4 ( 1056])-7 (. T)1 (he)4 ( o)]TJ 0.002 Tc -0.002 Tw [(v)2 (e)6 (r)5 (a)6 (ll me)6 (d)2 (ia)6 (n)2 ( tr)5 (e)6 (a)6 (tme)6 (n)2 (t d)2 (u)-8 (r)-5 (a)6 (tio)2 (n)2 ( w)4 (a)6 (s)1 ( 5)2 (4 )]TJ 0 Tc 0 Tw 25.61 0 Td [(w)2 (e)-6 (e)4 (ks)-1 ( i)-2 (n bot)-2 (h t)-2 (he)4 ( A)2 (C)-3 (-)3 (T)1 (H)2 ( a)4 (nd )]TJ -0.004 Tc 0.004 Tw -25.61 -1.17 Td [(T)-3 (C)-7 (H)-2 ( ar)-1 (m)-6 (s)-5 (. )]TJ EMC /P <>BDC 0 Tc 0 Tw 0 -1.66 TD [(T)1 (he)4 ( m)-2 (e)4 (di)-2 (a)4 (n num)-2 (be)4 (r)3 ( o)-10 (f)3 ( i)-2 (nf)3 (us)-1 (i)-2 (ons)-1 ( w)2 (a)4 (s)-1 ( 26 i)-2 (n t)-2 (he)4 ( A)2 (C)-3 (-)3 (T)1 (H)2 ( a)4 (r)3 (m)-2 ( a)4 (nd )-10 (30 i)-2 (n t)-2 (he)4 ( T)-9 (C)-3 (H)2 ( a)4 (r)3 (m)-2 (, i)-2 (nc)4 (l)-2 (udi)-2 (ng )]TJ 0 -1.17 TD [(w)2 (e)4 (e)4 (kl)-22 (y)20 ( i)-2 (nf)3 (us)-1 (i)-2 (ons)-1 ( dur)3 (i)-2 (n)-10 (g)10 ( t)-2 (he)4 ( c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)-7 (a)4 (p)-20 (y)20 ( pha)4 (s)-11 (e)4 ( a)-6 (nd e)4 (ve)4 (r)-17 (y)20 ( t)-2 (hr)-7 (e)4 (e)4 ( w)-8 (e)4 (e)4 (k dos)-1 (i)-12 (ng)10 ( i)-2 (n t)-2 (he )]TJ T* [(m)-2 (onot)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( pe)4 (r)3 (i)-2 (od. A)2 (m)-12 (ong)10 ( t)-2 (he)4 (s)-1 (e)-6 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 (, t)-2 (he)4 ( m)-12 (e)4 (di)-2 (a)4 (n a)-6 (g)10 (e )-6 (w)2 (a)4 (s)-1 ( 49 )]TJ -0.004 Tc 0.004 Tw 27.12 0 Td [(y)16 (e)-10 (ar)-1 (s)-5 ( \()-11 (r)-11 (an)-4 (g)-4 (e 2)-4 (2 )]TJ 0 Tc 0 Tw 6.4 0 Td [(t)-2 (o 74 )]TJ -0.003 Tc 0.003 Tw 2.3 0 Td [(y)17 (e)1 (a)-9 (rs)-4 (\). )]TJ 0 Tc 0 Tw -35.82 -1.16 Td [(I)13 (n S)-4 (t)-2 (ud)-20 (y )]TJ 0.002 Tc -0.002 Tw 3.66 0 Td [(4)2 (,)2 ( th)2 (e)6 ( to)2 (x)-8 (ic)6 (it)-10 (y)32 ( p)-8 (r)5 (o)2 (f)5 (ile)6 ( w)4 (a)6 (s)1 ( s)1 (imila)6 (r)5 ( to)2 ( th)2 (a)6 (t )-10 (r)5 (e)6 (p)2 (o)2 (r)5 (te)6 (d)2 ( in)2.1 ( S)-1.9 (tu)2 (d)2 (ie)6 (s )]TJ 0 Tc 0 Tw 24.11 0 Td (1 )Tj -0.004 Tc 0.004 Tw [(an)-4 (d )]TJ 0 Tc 0 Tw 2.45 0 Td [(2 w)2 (i)-2 (t)-2 (h t)-2 (he)4 ( e)4 (x)-10 (c)4 (e)4 (pt)-2 (i)-2 (on )]TJ -30.22 -1.17 Td [(of)3 ( a)4 ( l)-2 (ow)2 ( i)-2 (nc)4 (i)-2 (de)4 (nc)-6 (e)4 ( of)3 ( C)-3 (H)-8 (F)6 ( i)-2 (n t)-2 (he)4 ( T)1 (C)-3 (H)2 ( a)4 (r)3 (m)-2 (. )]TJ EMC /P <>BDC /TT1 1 Tf 0 -1.67 TD [(M)3 (e)4 (t)-2 (as)-1 (t)-2 (at)-2 (i)-2 (c)4 ( B)1 (r)-1 (e)4 (as)-1 (t)-2 ( C)-3 (anc)4 (e)-6 (r)-1 ( St)-2 (u)]TJ -0.004 Tc 0.004 Tw [(d)-4 (i)-6 (es )]TJ EMC /P <>BDC /TT0 1 Tf 0 -1.66 TD [(T)-3 (h)-4 (e d)-4 (at)-6 (a b)-4 (el)-6 (o)-4 (w )-12 (r)-1 (ef)-1 (l)-16 (ect)-6 ( ex)-13.9 (p)-4 (o)-4 (s)-5.1 (u)-4 (r)-0.9 (e t)-6 (o )]TJ 0.002 Tc -0.002 Tw 14.1 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6.1 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(i)-2 (n one)4 ( r)3 (a)4 (ndom)-2 (i)-2 (z)-6 (e)4 (d, ope)4 (n-)3 (l)-2 (a)-6 (be)4 (l)-2 ( s)-1 (t)-2 (ud)-10 (y)20 (, S)-4 (t)-2 (ud)-10 (y)20 ( 5, o)-10 (f)]TJ /T1_0 1 Tf (\002 )Tj /TT0 1 Tf -19.24 -1.17 Td [(c)4 (he)4 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y )10 (w)2 (i)-2 (t)-2 (h \()3 (n = )-6 (235\))3 ( or)3 ( w)2 (i)-2 (t)-2 (hout)-2 ( \()3 (n =)4 ( 234\))-7 ( t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h m)-2 (e)4 (t)-2 (a)4 (s)-1 (t)-2 (a)4 (t)-2 (i)-2 (c)4 ( br)3 (e)4 (a)4 (s)-1 (t)]TJ /T1_0 1 Tf (\002 )Tj /TT0 1 Tf 0 -1.17 TD [(c)4 (a)4 (nc)-6 (e)4 (r)3 (, a)4 (nd on)-10 (e)4 ( s)-1 (i)-2 (ng)10 (l)-12 (e)4 (-)]TJ 0.002 Tc -0.002 Tw 9.21 0 Td [(a)-4 (r)-5 (m s)1 (tu)2 (d)-8 (y)22 ( \()5 (S)-2 (tu)2 (d)-8 (y)22 ( 6)2 (; n)2 ( =)6 ( 2)2 (2)-8 (2)2 (\))5 ( in)2 ( p)2 (a)6 (tie)6 (n)2 (ts)1 ( w)4 (ith)2 ( me)6 (ta)6 (s)0.9 (ta)6.1 (tic)6.1 ( b)2 (r)4.9 (e)6.1 (a)5.9 (s)1 (t )-10 (c)6 (a)6 (n)2 (c)-4 (e)6 (r)5 (.)]TJ /T1_0 1 Tf (\002 )Tj /TT0 1 Tf -0.004 Tc 0.004 Tw -9.21 -1.17 Td [(D)-2 (at)-6 (a i)-6 (n )-4 (T)-3 (ab)-4 (l)-6 (e )]TJ 0 Tc 0 Tw [(3 )-10 (a)4 (r)3 (e)4 ( b)-10 (a)4 (s)-1 (e)4 (d)-10 ( on S)-4 (t)-2 (udi)-2 (e)4 (s)-1 ( 5 a)4 (nd 6.)]TJ /T1_0 1 Tf (\002 )Tj EMC /P <>BDC /TT0 1 Tf 0 -1.66 TD [(A)2 (m)-2 (ong)10 ( t)-2 (he)4 ( 464 )]TJ 0.002 Tc -0.002 Tw [(p)-8 (a)6 (tie)6 (n)2 (ts)1 ( tr)5 (e)6 (a)6 (te)6 (d)2 ( in)2 ( S)-2 (tu)2 (d)-8 (y)22 ( 5)2 (,)2 ( th)-8 (e)6 ( me)-4 (d)2 (ia)6 (n)2 ( a)-4 (g)12 (e)6 ( w)-6 (a)6 (s)1 ( 5)2 (2 )]TJ -0.004 Tc 0.004 Tw 26.79 0 Td [(y)16 (ea)-10 (r)-1 (s)-5 ( \()-1 (r)-11 (a)-10 (n)-4 (g)6 (e:)-6 ( 2)-4 (5)]TJ 0 Tc 0 Tw 6.42 0 Td (\22677 )Tj -0.003 Tc 0.003 Tw 1.77 0 Td [(y)17 (e)-9 (a)1 (rs)-14 (\).)]TJ /T1_0 1 Tf (\002 )Tj /TT0 1 Tf -0.01 Tc 0.01 Tw -34.98 -1.17 Td [(E)-9 (i)-12 (gh)]TJ 0.022 Tc -0.022 Tw 1.88 0 Td (ty)Tj 0 Tc 0 Tw 0.78 0 Td [(-)3 (ni)-2 (ne)4 ( p)-10 (e)4 (r)3 (c)-6 (e)4 (nt)-2 ( w)2 (e)4 (r)-7 (e)-6 ( W)-6 (hi)-2 (t)-2 (e)4 (, 5% )3 (B)7 (l)-2 (a)4 (c)4 (k, 1% )3 (A)-8 (s)-1 (i)-2 (a)4 (n a)4 (nd 5% )3 (ot)-2 (he)4 (r )-7 (r)3 (a)4 (c)4 (i)-12 (a)4 (l)-2 (/)-2 (e)4 (t)-2 (hni)-2 (c)4 ( gr)3 (oups)-1 (.)]TJ /T1_0 1 Tf (\002 )Tj /TT0 1 Tf -0.002 Tc 0.002 Tw -2.66 -1.16 Td [(Al)-4 (l )]TJ -0.004 Tc 0.004 Tw 1.53 0 Td [(p)-4 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( r)-1 (ecei)-6 (v)-14 (ed)-4 ( 4 )]TJ 0.002 Tc -0.002 Tw 7.74 0 Td [(mg)12 (/k)-8 (g)12 ( in)2 (itia)6 (l d)2 (o)2 (s)1 (e)6 ( o)2 (f )5 (tr)5 (a)6 (s)1 (tu)-8 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 13.7 0 Td [(f)3 (ol)-2 (l)-2 (ow)2 (e)4 (d b)-10 (y)20 ( 2 m)-12 (g/)-2 (kg)10 ( w)2 (e)-6 (e)4 (kl)-22 (y)20 (. T)1 (he)]TJ /T1_0 1 Tf (\002 )Tj /TT0 1 Tf -0.004 Tc 0.004 Tw -22.97 -1.17 Td [(p)-4 (er)-1 (cen)-4 (t)-16 (a)-10 (g)6 (es)-5 ( o)-4 (f)-1 ( p)-14 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( w)-12 (h)-4 (o)-4 ( r)-1 (ecei)-6 (v)-14 (ed )]TJ 0.002 Tc -0.002 Tw 15.02 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ /C2_0 1 Tf 0 Tc 0 Tw 5.14 0 Td [<0057>-2 <0055>3 <0048>4 <0044>4 <0057>-2 <0050>-2 <0048>4 <00510057>-2 <00030049>3 <00520055>3 <00030095>-1 <0003001900030050>-2 <005200510057>-2 <004B00560003>-11 <0044>4 <0051004700030095>-1 <0003001400150003>]TJ /TT0 1 Tf [(m)-2 (ont)-2 (hs)]TJ /T1_0 1 Tf (\002 )Tj /TT0 1 Tf -20.16 -1.17 Td [(w)2 (e)4 (r)3 (e)4 ( 58)-10 (%)3 ( a)4 (nd 9%)3 (, )-10 (r)3 (e)4 (s)-1 (pe)-6 (c)4 (t)-2 (i)-2 (ve)4 (l)-12 (y)20 (.)]TJ /T1_0 1 Tf (\002 )Tj EMC /P <>BDC /TT0 1 Tf T* [(A)2 (m)-2 (ong)10 ( t)-2 (he)4 ( 352 )]TJ 0.002 Tc -0.002 Tw [(p)-8 (a)6 (tie)6 (n)2 (ts)1 ( tr)5 (e)6 (a)6 (te)6 (d)2 ( in)2 ( s)1 (in)-8 (g)12 (le)6 ( a)-4 (g)2 (e)6 (n)2 (t s)1 (tu)2 (d)2 (ie)6 (s)1 ( \()5 (2)2 (1)2 (3 )]TJ 0 Tc 0 Tw 23.99 0 Td [(pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( f)3 (r)3 (om)-2 ( S)-4 (t)-2 (ud)-10 (y)20 ( 6\))3 (, t)-2 (he)4 ( m)-2 (e)4 (di)-12 (a)4 (n )]TJ /T1_0 1 Tf (\002)Tj /TT0 1 Tf -0.004 Tc 0.004 Tw -23.99 -1.17 Td [(ag)-4 (e w)-2 (as)-5 ( 5)-4 (0 )]TJ 0.014 Tw 4.7 0 Td [(y)16 (e)-10 (ar)-1 (s)-5 ( \()-1 (r)-1 (an)-14 (g)-4 (e 2)-4 (8)]TJ 0 Tc 0 Tw 6.16 0 Td (\22686 )Tj -0.004 Tc 0.004 Tw 1.76 0 Td [(y)16 (e)-10 (ar)-1 (s)-5 (\))-1 (,)-4 ( 8)-4 (6)-14 (%)-1 ( w)-2 (e)-10 (r)-1 (e )-10 (W)-10 (h)-4 (i)-6 (t)-6 (e,)-4 ( 3)-3.9 (%)-1 ( w)-2.1 (er)-0.9 (e )-10 (B)3 (l)-6 (ack)-4 (,)-4 ( 3)-14 (%)-1 ( w)-2 (er)-11 (e A)-2 (s)-5 (i)-6 (an)-4 (,)-4 ( an)-4 (d)]TJ /T1_0 1 Tf (\002 )Tj /TT0 1 Tf 0 Tc 0 Tw -12.62 -1.17 Td [(8%)3 ( i)-2 (n ot)-2 (he)4 (r)3 ( r)3 (a)-6 (c)4 (i)-2 (a)4 (l)-2 (/)-2 (e)4 (t)-2 (hni)-2 (c )-6 (g)10 (r)3 (oups)-1 (. M)-1 (o)]TJ -0.004 Tc 0.004 Tw [(s)-5 (t)-6 ( o)-4 (f)-1 ( t)-6 (h)-4 (e p)-14 (at)-6 (i)-6 (e)-10 (n)-4 (t)-6 (s)-5 ( r)-1 (ecei)-6 (v)-3.9 (ed)-4 ( 4 )]TJ 0.002 Tc -0.002 Tw 25.93 0 Td [(m)-10 (g)12 (/k)-8 (g)12 ( in)2 (itia)6 (l d)2 (o)2 (s)1 (e)6 ( o)2 (f)]TJ /T1_0 1 Tf (\002 )Tj /TT0 1 Tf -25.93 -1.16 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(f)3 (ol)-2 (l)-2 (ow)2 (e)4 (d b)-10 (y )10 (2 )]TJ -0.004 Tc 0.004 Tw [(m)-6 (g)6 (/)-6 (k)-14 (g)6 ( w)-2 (e)-10 (ek)-4 (l)-16 (y)16 (.)-4 ( T)-3 (h)-14 (e p)-4 (e)-10 (r)-11 (cen)-3.9 (t)-6 (a)-10 (g)5.9 (es)-4.9 ( o)-14 (f)-1 ( p)-4 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( w)-2 (h)-4 (o )-14 (r)-1 (ecei)-6 (v)-14 (ed )]TJ 0.002 Tc -0.002 Tw 28.82 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b)]TJ /T1_0 1 Tf (\002 )Tj /C2_0 1 Tf 0 Tc 0 Tw -33.96 -1.17 Td [<0057>-2 <0055>3 <0048>4 <0044>4 <0057>-2 <0050>-2 <0048>4 <00510057>-2 <00030049>3 <00520055>3 <00030095>-1 <0003001900030050>-2 <005200510057>-2 <004B00560003>-11 <0044>4 <0051004700030095>-1 <0003001400150003>]TJ /TT0 1 Tf [(m)-2 (ont)-2 (hs)-1 ( w)2 (e)4 (r)3 (e)4 ( 31)-10 (%)3 ( a)4 (nd 16%)3 (, r)-7 (e)4 (s)-1 (pe)4 (c)4 (t)-2 (i)-2 (ve)4 (l)-22 (y)20 (.)]TJ /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC /TT0 1 Tf 19 -4.5 Td (10)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 31.5168 26.9687 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4677 0 obj <>>>/Resources 4514 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4678 0 obj <> endobj 4679 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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f 474.12 655.2 0.72 0.72 re f 474.84 655.2 64.44 0.72 re f 539.28 655.2 0.72 0.72 re f 72 636.48 0.72 18.72 re f 189.84 636.48 0.72 18.72 re f 256.32 636.48 0.72 18.72 re f 330.72 636.48 0.72 18.72 re f 399 636.48 0.72 18.72 re f 473.4 636.48 0.72 18.72 re f 539.28 636.48 0.72 18.72 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 155.6366 641.1459 Tm ( )Tj 8.663 0 Td ( )Tj 6.641 0 Td ( )Tj 6.456 0 Td ( )Tj 6.217 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 635.76 0.72 0.72 re f 72.72 635.76 117.12 0.72 re f 189.84 635.76 0.72 0.72 re f 190.56 635.76 65.76 0.72 re f 256.32 635.76 0.72 0.72 re f 257.04 635.76 73.68 0.72 re f 330.72 635.76 0.72 0.72 re f 331.44 635.76 67.559 0.72 re f 399 635.76 0.72 0.72 re f 399.72 635.76 73.68 0.72 re f 473.4 635.76 0.72 0.72 re f 474.12 635.76 65.16 0.72 re f 539.28 635.76 0.72 0.72 re f 72 617.16 0.72 18.6 re f 189.84 617.16 0.72 18.6 re f 256.32 617.16 0.72 18.6 re f 330.72 617.16 0.72 18.6 re f 399 617.16 0.72 18.6 re f 473.4 617.16 0.72 18.6 re f 539.28 617.16 0.72 18.6 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 135.7099 621.7059 Tm ( )Tj ET Q 77.76 601.32 37.32 0.481 re f q 190.2 597.72 66.48 18.6 re W n q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 243.9547 625.7859 Tm ( )Tj ET Q Q q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 314.5147 621.7059 Tm ( )Tj 6.457 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 616.44 0.72 0.72 re f 72.72 616.44 117.12 0.72 re f 189.84 616.44 0.72 0.72 re f 190.56 616.44 0.72 0.72 re f 191.28 616.44 65.04 0.72 re f 256.32 616.44 0.72 0.72 re f 257.04 616.44 0.72 0.72 re f 257.76 616.44 72.96 0.72 re f 330.72 616.44 0.72 0.72 re f 331.44 616.44 0.72 0.72 re f 332.16 616.44 66.839 0.72 re f 399 616.44 0.72 0.72 re f 399.72 616.44 0.72 0.72 re f 400.44 616.44 72.96 0.72 re f 473.4 616.44 0.72 0.72 re f 474.12 616.44 0.72 0.72 re f 474.84 616.44 64.44 0.72 re f 539.28 616.44 0.72 0.72 re f 72 597.72 0.72 18.72 re f 539.28 597.72 0.72 18.72 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 151.32 602.3859 Tm ( )Tj 9.304 0 Td ( )Tj 6.391 0 Td ( )Tj 6.456 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 597 0.72 0.72 re f 72.72 597 117.12 0.72 re f 189.84 597 0.72 0.72 re f 190.56 597 0.72 0.72 re f 191.28 597 65.04 0.72 re f 256.32 597 0.72 0.72 re f 257.04 597 0.72 0.72 re f 257.76 597 72.96 0.72 re f 330.72 597 0.72 0.72 re f 331.44 597 0.72 0.72 re f 332.16 597 66.839 0.72 re f 399 597 0.72 0.72 re f 399.72 597 0.72 0.72 re f 400.44 597 72.96 0.72 re f 473.4 597 0.72 0.72 re f 474.12 597 0.72 0.72 re f 474.84 597 64.44 0.72 re f 539.28 597 0.72 0.72 re f 72 578.28 0.72 18.72 re f 189.84 578.28 0.72 18.72 re f 256.32 578.28 0.72 18.72 re f 330.72 578.28 0.72 18.72 re f 399 578.28 0.72 18.72 re f 473.4 578.28 0.72 18.72 re f 539.28 578.28 0.72 18.72 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 153.1137 582.9459 Tm ( )Tj 9.142 0 Td ( )Tj 6.391 0 Td ( )Tj 6.456 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 577.56 0.72 0.72 re f 72.72 577.56 117.12 0.72 re f 189.84 577.56 0.72 0.72 re f 190.56 577.56 65.76 0.72 re f 256.32 577.56 0.72 0.72 re f 257.04 577.56 73.68 0.72 re f 330.72 577.56 0.72 0.72 re f 331.44 577.56 67.559 0.72 re f 399 577.56 0.72 0.72 re f 399.72 577.56 73.68 0.72 re f 473.4 577.56 0.72 0.72 re f 474.12 577.56 65.16 0.72 re f 539.28 577.56 0.72 0.72 re f 72 558.96 0.72 18.599 re f 189.84 558.96 0.72 18.599 re f 256.32 558.96 0.72 18.599 re f 330.72 558.96 0.72 18.599 re f 399 558.96 0.72 18.599 re f 473.4 558.96 0.72 18.599 re f 539.28 558.96 0.72 18.599 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 159.8318 563.5059 Tm ( )Tj 8.283 0 Td ( )Tj 6.641 0 Td ( )Tj 6.456 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 558.24 0.72 0.72 re f 72.72 558.24 117.12 0.72 re f 189.84 558.24 0.72 0.72 re f 190.56 558.24 65.76 0.72 re f 256.32 558.24 0.72 0.72 re f 257.04 558.24 73.68 0.72 re f 330.72 558.24 0.72 0.72 re f 331.44 558.24 67.559 0.72 re f 399 558.24 0.72 0.72 re f 399.72 558.24 73.68 0.72 re f 473.4 558.24 0.72 0.72 re f 474.12 558.24 65.16 0.72 re f 539.28 558.24 0.72 0.72 re f 72 539.52 0.72 18.72 re f 189.84 539.52 0.72 18.72 re f 256.32 539.52 0.72 18.72 re f 330.72 539.52 0.72 18.72 re f 399 539.52 0.72 18.72 re f 473.4 539.52 0.72 18.72 re f 539.28 539.52 0.72 18.72 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 159.8318 544.1859 Tm ( )Tj 8.283 0 Td ( )Tj 6.641 0 Td ( )Tj 6.456 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 538.8 0.72 0.72 re f 72.72 538.8 117.12 0.72 re f 189.84 538.8 0.72 0.72 re f 190.56 538.8 65.76 0.72 re f 256.32 538.8 0.72 0.72 re f 257.04 538.8 73.68 0.72 re f 330.72 538.8 0.72 0.72 re f 331.44 538.8 67.559 0.72 re f 399 538.8 0.72 0.72 re f 399.72 538.8 73.68 0.72 re f 473.4 538.8 0.72 0.72 re f 474.12 538.8 65.16 0.72 re f 539.28 538.8 0.72 0.72 re f 72 520.08 0.72 18.72 re f 189.84 520.08 0.72 18.72 re f 256.32 520.08 0.72 18.72 re f 330.72 520.08 0.72 18.72 re f 399 520.08 0.72 18.72 re f 473.4 520.08 0.72 18.72 re f 539.28 520.08 0.72 18.72 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 191.3952 524.7459 Tm ( )Tj 5.424 0 Td ( )Tj 6.641 0 Td ( )Tj 6.456 0 Td ( )Tj 6.217 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 519.36 0.72 0.72 re f 72.72 519.36 117.12 0.72 re f 189.84 519.36 0.72 0.72 re f 190.56 519.36 65.76 0.72 re f 256.32 519.36 0.72 0.72 re f 257.04 519.36 73.68 0.72 re f 330.72 519.36 0.72 0.72 re f 331.44 519.36 67.559 0.72 re f 399 519.36 0.72 0.72 re f 399.72 519.36 73.68 0.72 re f 473.4 519.36 0.72 0.72 re f 474.12 519.36 65.16 0.72 re f 539.28 519.36 0.72 0.72 re f 72 500.76 0.72 18.6 re f 189.84 500.76 0.72 18.6 re f 256.32 500.76 0.72 18.6 re f 330.72 500.76 0.72 18.6 re f 399 500.76 0.72 18.6 re f 473.4 500.76 0.72 18.6 re f 539.28 500.76 0.72 18.6 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 162.36 505.3059 Tm ( )Tj 8.054 0 Td ( )Tj 6.641 0 Td ( )Tj 6.206 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 500.04 0.72 0.72 re f 72.72 500.04 117.12 0.72 re f 189.84 500.04 0.72 0.72 re f 190.56 500.04 65.76 0.72 re f 256.32 500.04 0.72 0.72 re f 257.04 500.04 73.68 0.72 re f 330.72 500.04 0.72 0.72 re f 331.44 500.04 67.559 0.72 re f 399 500.04 0.72 0.72 re f 399.72 500.04 73.68 0.72 re f 473.4 500.04 0.72 0.72 re f 474.12 500.04 65.16 0.72 re f 539.28 500.04 0.72 0.72 re f 72 481.32 0.72 18.72 re f 189.84 481.32 0.72 18.72 re f 256.32 481.32 0.72 18.72 re f 330.72 481.32 0.72 18.72 re f 399 481.32 0.72 18.72 re f 473.4 481.32 0.72 18.72 re f 539.28 481.32 0.72 18.72 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 149.7528 485.9859 Tm ( )Tj ET Q 77.76 465.6 51.36 0.481 re f q 190.2 461.88 66.48 18.72 re W n q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 243.9547 489.946 Tm ( )Tj ET Q Q q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 314.5147 485.9859 Tm ( )Tj 6.457 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 480.6 0.72 0.72 re f 72.72 480.6 117.12 0.72 re f 189.84 480.6 0.72 0.72 re f 190.56 480.6 0.72 0.72 re f 191.28 480.6 65.04 0.72 re f 256.32 480.6 0.72 0.72 re f 257.04 480.6 0.72 0.72 re f 257.76 480.6 72.96 0.72 re f 330.72 480.6 0.72 0.72 re f 331.44 480.6 0.72 0.72 re f 332.16 480.6 66.839 0.72 re f 399 480.6 0.72 0.72 re f 399.72 480.6 0.72 0.72 re f 400.44 480.6 72.96 0.72 re f 473.4 480.6 0.72 0.72 re f 474.12 480.6 0.72 0.72 re f 474.84 480.6 64.44 0.72 re f 539.28 480.6 0.72 0.72 re f 72 461.88 0.72 18.72 re f 539.28 461.88 0.72 18.72 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 184.0757 466.5459 Tm ( )Tj 6.337 0 Td ( )Tj 6.391 0 Td ( )Tj 6.456 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 461.16 0.72 0.72 re f 72.72 461.16 117.12 0.72 re f 189.84 461.16 0.72 0.72 re f 190.56 461.16 0.72 0.72 re f 191.28 461.16 65.04 0.72 re f 256.32 461.16 0.72 0.72 re f 257.04 461.16 0.72 0.72 re f 257.76 461.16 72.96 0.72 re f 330.72 461.16 0.72 0.72 re f 331.44 461.16 0.72 0.72 re f 332.16 461.16 66.839 0.72 re f 399 461.16 0.72 0.72 re f 399.72 461.16 0.72 0.72 re f 400.44 461.16 72.96 0.72 re f 473.4 461.16 0.72 0.72 re f 474.12 461.16 0.72 0.72 re f 474.84 461.16 64.44 0.72 re f 539.28 461.16 0.72 0.72 re f 72 442.56 0.72 18.6 re f 189.84 442.56 0.72 18.6 re f 256.32 442.56 0.72 18.6 re f 330.72 442.56 0.72 18.6 re f 399 442.56 0.72 18.6 re f 473.4 442.56 0.72 18.6 re f 539.28 442.56 0.72 18.6 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 148.9133 447.1059 Tm ( )Tj 9.522 0 Td ( )Tj 6.391 0 Td ( )Tj 6.456 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 441.84 0.72 0.72 re f 72.72 441.84 117.12 0.72 re f 189.84 441.84 0.72 0.72 re f 190.56 441.84 65.76 0.72 re f 256.32 441.84 0.72 0.72 re f 257.04 441.84 73.68 0.72 re f 330.72 441.84 0.72 0.72 re f 331.44 441.84 67.559 0.72 re f 399 441.84 0.72 0.72 re f 399.72 441.84 73.68 0.72 re f 473.4 441.84 0.72 0.72 re f 474.12 441.84 65.16 0.72 re f 539.28 441.84 0.72 0.72 re f 72 423.12 0.72 18.72 re f 189.84 423.12 0.72 18.72 re f 256.32 423.12 0.72 18.72 re f 330.72 423.12 0.72 18.72 re f 399 423.12 0.72 18.72 re f 473.4 423.12 0.72 18.72 re f 539.28 423.12 0.72 18.72 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 145.1928 427.7859 Tm ( )Tj 9.859 0 Td ( )Tj 6.391 0 Td ( )Tj 6.206 0 Td ( )Tj 6.717 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 422.4 0.72 0.72 re f 72.72 422.4 117.12 0.72 re f 189.84 422.4 0.72 0.72 re f 190.56 422.4 65.76 0.72 re f 256.32 422.4 0.72 0.72 re f 257.04 422.4 73.68 0.72 re f 330.72 422.4 0.72 0.72 re f 331.44 422.4 67.559 0.72 re f 399 422.4 0.72 0.72 re f 399.72 422.4 73.68 0.72 re f 473.4 422.4 0.72 0.72 re f 474.12 422.4 65.16 0.72 re f 539.28 422.4 0.72 0.72 re f 72 403.68 0.72 18.72 re f 189.84 403.68 0.72 18.72 re f 256.32 403.68 0.72 18.72 re f 330.72 403.68 0.72 18.72 re f 399 403.68 0.72 18.72 re f 473.4 403.68 0.72 18.72 re f 539.28 403.68 0.72 18.72 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 160.5494 408.3459 Tm ( )Tj 8.467 0 Td ( )Tj 6.391 0 Td ( )Tj 6.456 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 402.96 0.72 0.72 re f 72.72 402.96 117.12 0.72 re f 189.84 402.96 0.72 0.72 re f 190.56 402.96 65.76 0.72 re f 256.32 402.96 0.72 0.72 re f 257.04 402.96 73.68 0.72 re f 330.72 402.96 0.72 0.72 re f 331.44 402.96 67.559 0.72 re f 399 402.96 0.72 0.72 re f 399.72 402.96 73.68 0.72 re f 473.4 402.96 0.72 0.72 re f 474.12 402.96 65.16 0.72 re f 539.28 402.96 0.72 0.72 re f 72 384.36 0.72 18.599 re f 189.84 384.36 0.72 18.599 re f 256.32 384.36 0.72 18.599 re f 330.72 384.36 0.72 18.599 re f 399 384.36 0.72 18.599 re f 473.4 384.36 0.72 18.599 re f 539.28 384.36 0.72 18.599 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 148.3171 388.9059 Tm ( )Tj 9.326 0 Td ( )Tj 6.641 0 Td ( )Tj 6.206 0 Td ( )Tj 6.717 0 Td ( )Tj 6.098 0 Td ( )Tj ET Q 72 383.64 0.72 0.72 re f 72.72 383.64 117.12 0.72 re f 189.84 383.64 0.72 0.72 re f 190.56 383.64 65.76 0.72 re f 256.32 383.64 0.72 0.72 re f 257.04 383.64 73.68 0.72 re f 330.72 383.64 0.72 0.72 re f 331.44 383.64 67.559 0.72 re f 399 383.64 0.72 0.72 re f 399.72 383.64 73.68 0.72 re f 473.4 383.64 0.72 0.72 re f 474.12 383.64 65.16 0.72 re f 539.28 383.64 0.72 0.72 re f 72 364.92 0.72 18.72 re f 189.84 364.92 0.72 18.72 re f 256.32 364.92 0.72 18.72 re f 330.72 364.92 0.72 18.72 re f 399 364.92 0.72 18.72 re f 473.4 364.92 0.72 18.72 re f 539.28 364.92 0.72 18.72 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 118.5537 369.5859 Tm ( )Tj ET Q 77.76 349.2 20.16 0.48 re f q 190.2 345.48 66.48 18.72 re W n q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 243.9547 373.5459 Tm ( )Tj ET Q Q q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 314.5147 369.5859 Tm ( )Tj 6.457 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 364.2 0.72 0.72 re f 72.72 364.2 117.12 0.72 re f 189.84 364.2 0.72 0.72 re f 190.56 364.2 0.72 0.72 re f 191.28 364.2 65.04 0.72 re f 256.32 364.2 0.72 0.72 re f 257.04 364.2 0.72 0.72 re f 257.76 364.2 72.96 0.72 re f 330.72 364.2 0.72 0.72 re f 331.44 364.2 0.72 0.72 re f 332.16 364.2 66.839 0.72 re f 399 364.2 0.72 0.72 re f 399.72 364.2 0.72 0.72 re f 400.44 364.2 72.96 0.72 re f 473.4 364.2 0.72 0.72 re f 474.12 364.2 0.72 0.72 re f 474.84 364.2 64.44 0.72 re f 539.28 364.2 0.72 0.72 re f 72 345.48 0.72 18.72 re f 539.28 345.48 0.72 18.72 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 132.3533 350.1459 Tm ( )Tj 11.022 0 Td ( )Tj 6.391 0 Td ( )Tj 6.456 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 344.76 0.72 0.72 re f 72.72 344.76 117.12 0.72 re f 189.84 344.76 0.72 0.72 re f 190.56 344.76 0.72 0.72 re f 191.28 344.76 65.04 0.72 re f 256.32 344.76 0.72 0.72 re f 257.04 344.76 0.72 0.72 re f 257.76 344.76 72.96 0.72 re f 330.72 344.76 0.72 0.72 re f 331.44 344.76 0.72 0.72 re f 332.16 344.76 66.839 0.72 re f 399 344.76 0.72 0.72 re f 399.72 344.76 0.72 0.72 re f 400.44 344.76 72.96 0.72 re f 473.4 344.76 0.72 0.72 re f 474.12 344.76 0.72 0.72 re f 474.84 344.76 64.44 0.72 re f 539.28 344.76 0.72 0.72 re f 72 326.16 0.72 18.6 re f 189.84 326.16 0.72 18.6 re f 256.32 326.16 0.72 18.6 re f 330.72 326.16 0.72 18.6 re f 399 326.16 0.72 18.6 re f 473.4 326.16 0.72 18.6 re f 539.28 326.16 0.72 18.6 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 179.1518 330.7059 Tm ( )Tj 6.533 0 Td ( )Tj 6.641 0 Td ( )Tj 6.206 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 325.44 0.72 0.72 re f 72.72 325.44 117.12 0.72 re f 189.84 325.44 0.72 0.72 re f 190.56 325.44 65.76 0.72 re f 256.32 325.44 0.72 0.72 re f 257.04 325.44 73.68 0.72 re f 330.72 325.44 0.72 0.72 re f 331.44 325.44 67.559 0.72 re f 399 325.44 0.72 0.72 re f 399.72 325.44 73.68 0.72 re f 473.4 325.44 0.72 0.72 re f 474.12 325.44 65.16 0.72 re f 539.28 325.44 0.72 0.72 re f 72 306.72 0.72 18.72 re f 189.84 306.72 0.72 18.72 re f 256.32 306.72 0.72 18.72 re f 330.72 306.72 0.72 18.72 re f 399 306.72 0.72 18.72 re f 473.4 306.72 0.72 18.72 re f 539.28 306.72 0.72 18.72 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 133.5566 311.386 Tm ( )Tj 10.663 0 Td ( )Tj 6.641 0 Td ( )Tj 6.206 0 Td ( )Tj 6.467 0 Td [( )-4935 ( )-1326 ( )]TJ ET Q 72 306 0.72 0.72 re f 72.72 306 117.12 0.72 re f 189.84 306 0.72 0.72 re f 190.56 306 65.76 0.72 re f 256.32 306 0.72 0.72 re f 257.04 306 73.68 0.72 re f 330.72 306 0.72 0.72 re f 331.44 306 67.559 0.72 re f 399 306 0.72 0.72 re f 399.72 306 73.68 0.72 re f 473.4 306 0.72 0.72 re f 474.12 306 65.16 0.72 re f 539.28 306 0.72 0.72 re f 72 287.28 0.72 18.72 re f 189.84 287.28 0.72 18.72 re f 256.32 287.28 0.72 18.72 re f 330.72 287.28 0.72 18.72 re f 399 287.28 0.72 18.72 re f 473.4 287.28 0.72 18.72 re f 539.28 287.28 0.72 18.72 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 145.4361 291.946 Tm ( )Tj ET Q 77.76 271.56 47.04 0.481 re f q 190.2 267.96 66.48 18.6 re W n q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 243.9547 295.9059 Tm ( )Tj ET Q Q q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 314.5147 291.946 Tm ( )Tj 6.457 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 286.56 0.72 0.72 re f 72.72 286.56 117.12 0.72 re f 189.84 286.56 0.72 0.72 re f 190.56 286.56 0.72 0.72 re f 191.28 286.56 65.04 0.72 re f 256.32 286.56 0.72 0.72 re f 257.04 286.56 0.72 0.72 re f 257.76 286.56 72.96 0.72 re f 330.72 286.56 0.72 0.72 re f 331.44 286.56 0.72 0.72 re f 332.16 286.56 66.839 0.72 re f 399 286.56 0.72 0.72 re f 399.72 286.56 0.72 0.72 re f 400.44 286.56 72.96 0.72 re f 473.4 286.56 0.72 0.72 re f 474.12 286.56 0.72 0.72 re f 474.84 286.56 64.44 0.72 re f 539.28 286.56 0.72 0.72 re f 72 267.96 0.72 18.6 re f 539.28 267.96 0.72 18.6 re f q 72.72 235.92 117.12 31.2 re W n q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 0.004 Tc 3.485 Tw 3 Tr 11.04 0 0 11.04 205.4344 272.6259 Tm ( )Tj ET Q Q q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 149.5094 259.9059 Tm ( )Tj 9.218 0.576 Td ( )Tj 6.641 0 Td ( )Tj 6.456 0 Td ( )Tj 6.467 0 Td ( )Tj 6.098 0 Td ( )Tj ET Q 72 267.24 0.72 0.72 re f 72.72 267.24 117.12 0.72 re f 189.84 267.24 0.72 0.72 re f 190.56 267.24 0.72 0.72 re f 191.28 267.24 65.04 0.72 re f 256.32 267.24 0.72 0.72 re f 257.04 267.24 0.72 0.72 re f 257.76 267.24 72.96 0.72 re f 330.72 267.24 0.72 0.72 re f 331.44 267.24 0.72 0.72 re f 332.16 267.24 66.839 0.72 re f 399 267.24 0.72 0.72 re f 399.72 267.24 0.72 0.72 re f 400.44 267.24 72.96 0.72 re f 473.4 267.24 0.72 0.72 re f 474.12 267.24 0.72 0.72 re f 474.84 267.24 64.44 0.72 re f 539.28 267.24 0.72 0.72 re f 72 235.8 0.72 31.44 re f 72 235.08 0.72 0.72 re f 72 235.08 0.72 0.72 re f 72.72 235.08 117.12 0.72 re f 189.84 235.8 0.72 31.44 re f 189.84 235.08 0.72 0.72 re f 190.56 235.08 65.76 0.72 re f 256.32 235.8 0.72 31.44 re f 256.32 235.08 0.72 0.72 re f 257.04 235.08 73.68 0.72 re f 330.72 235.8 0.72 31.44 re f 330.72 235.08 0.72 0.72 re f 331.44 235.08 67.559 0.72 re f 399 235.8 0.72 31.44 re f 399 235.08 0.72 0.72 re f 399.72 235.08 73.68 0.72 re f 473.4 235.8 0.72 31.44 re f 473.4 235.08 0.72 0.72 re f 474.12 235.08 65.16 0.72 re f 539.28 235.8 0.72 31.44 re f 539.28 235.08 0.72 0.72 re f 539.28 235.08 0.72 0.72 re f q 1 0 0 1 -20.634735 -18.705933 cm BT /TT0 1 Tf 3 Tr 9.96 0 0 9.96 95.5147 244.5459 Tm ( )Tj 0.002 Tc 0.001 Tw 3.567 0 Td ( )Tj 0 Tc 0 Tw 5.156 0 Td ( )Tj 0.006 Tc -0.003 Tw 2.639 0 Td [( )-2168.7 ( )-1951.8 ( )]TJ 0 Tc 0 Tw 25.855 0 Td ( )Tj -37.181 -1.157 Td ( )Tj 0.006 Tc -0.003 Tw 11.361 0 Td ( )Tj 0 Tc 0 Tw 15.482 0 Td ( )Tj 12 0 0 12 428.1547 207.4659 Tm ( )Tj -15.36 -1.17 Td [( )-1440 ( )]TJ 23.97 0 Td ( )Tj -29.85 -1.67 Td ( )Tj 13.07 -2.83 Td ( )Tj 13.86 0 Td ( )Tj -28.05 -1.16 Td [( )-1440 ( )]TJ 0.01 Tw 14.51 0 Td ( )Tj 0 Tw 18.89 0 Td ( )Tj 0.002 Tc -0.002 Tw -33.58 -1.17 Td ( )Tj 24.16 0 Td ( )Tj 8.87 0 Td ( )Tj /C2_0 1 Tf 0 Tc 0 Tw -15.35 -1.17 Td <0003>Tj /TT0 1 Tf 5.33 0 Td ( )Tj 9.22 0 Td ( )Tj ET Q EMC 1 0 0 1 -20.634735 -18.705933 cm BT /TH <>BDC /TT1 1 Tf -0.002 Tc 11.04 0 0 11.04 229.559 724.7806 Tm [(Si)-6.7 (ng)-2 (l)4.3 (e )]TJ -0.005 Tc -0.533 -1.152 Td [(Ag)-5 (e)-6.7 (n)-3.3 (t)]TJ 0 Tc 6.96 0 0 6.96 251.8747 716.0259 Tm (a )Tj 11.04 0 0 11.04 258.1147 712.0659 Tm (n )Tj -2.435 -1.152 Td [(= )5 (352 )]TJ EMC /TH <>BDC -0.002 Tc 4.663 2.304 Td [(T)2 (r)-3.7 (a)-2 (s)-4.3 (t)-5.9 (uz)7.2 (um)-6 (a)-2 (b )]TJ 0 Tc 0.391 -1.152 Td [(+)4.8 ( P)-8.6 (ac)9.2 (l)-4.6 (i)6.3 (t)-4 (ax)10.9 (e)-1.7 (l )]TJ 1.174 -1.152 Td [(n )2 (= )5 (91 )]TJ EMC /TH <>BDC 5.695 2.304 Td [(P)-8.6 (ac)9.3 (l)6.2 (i)-4.6 (t)-4 (ax)10.9 (e)-1.6 (l )]TJ -0.005 Tc 0.837 -1.152 Td [(Al)-9.6 (o)-5 (n)-3.4 (e )]TJ 0 Tc -0.065 -1.152 Td [(n )2 (= )5 (95 )]TJ EMC /TH <>BDC -0.002 Tc 4.891 2.304 Td [(T)2 (r)-3.7 (a)-2 (s)-4.3 (t)-5.9 (uz)7.2 (um)-6 (a)-2 (b )]TJ -0.005 Tc 0.005 Tw 1.576 -1.152 Td (+ AC)Tj 0 Tc 0 Tw 6.96 0 0 6.96 467.6347 716.0259 Tm (b )Tj 11.04 0 0 11.04 439.9099 699.3478 Tm [(n )2 (= )5 (143 )]TJ EMC /TH <>BDC -0.005 Tc 5.652 1.728 Td (AC)Tj 0 Tc 6.96 0 0 6.96 518.1547 722.3859 Tm (b )Tj -0.005 Tc 11.04 0 0 11.04 524.7547 718.4259 Tm [(Al)-9.6 (o)-5 (n)-3.4 (e )]TJ 0 Tc -1.326 -1.152 Td [(n )2 (= )5 (135 )]TJ EMC /TH <>BDC /TT0 1 Tf 0.002 Tc -37.294 -2.337 Td [(Mu)2 (scu)12.9 (l)-2.6 (o)2 (sk)12.9 (el)8.3 (et)8.3 (al )]TJ EMC /TH <>BDC 0 Tc 1.087 -1.75 Td [(B)4 (one)-1.7 ( pa)9.2 (i)-4.6 (n )]TJ EMC /TD <>BDC 11.435 0 Td (7% )Tj EMC /TD <>BDC 6.141 0 Td (24% )Tj EMC /TD <>BDC 6.456 0 Td (18% )Tj EMC /TD <>BDC 6.717 0 Td (7% )Tj EMC /TD <>BDC 6.348 0 Td (7% )Tj EMC /TH <>BDC 0.005 Tc -37.097 -1.761 Td [(A)9.6 (r)1.1 (th)5 (r)11.9 (a)3.3 (lg)15.9 (ia )]TJ EMC /TD <>BDC 0 Tc 11.435 0 Td (6% )Tj EMC /TD <>BDC 6.141 0 Td (37% )Tj EMC /TD <>BDC 6.456 0 Td (21% )Tj EMC /TD <>BDC 6.717 0 Td (8% )Tj EMC /TD <>BDC 6.348 0 Td (9% )Tj EMC /TH <>BDC -38.184 -1.761 Td [(N)4.6 (e)-1.6 (r)-4 (v)10.9 (ous )]TJ EMC /TH <>BDC 1.087 -1.75 Td [(I)17.8 (ns)-2.3 (o)-10.9 (m)17.1 (ni)-4.6 (a )]TJ EMC /TD <>BDC 11.185 0 Td (14% )Tj EMC /TD <>BDC 6.391 0 Td (25% )Tj EMC /TD <>BDC 6.456 0 Td (13% )Tj EMC /TD <>BDC 6.467 0 Td (29% )Tj EMC /TD <>BDC 6.348 0 Td (15% )Tj EMC /TH <>BDC -0.009 Tc -36.847 -1.761 Td [(D)-4.4 (i)-13.6 (zzi)-13.6 (n)-9 (e)-10.7 (s)-11.2 (s )]TJ EMC /TD <>BDC 0 Tc 11.185 0 Td (13% )Tj EMC /TD <>BDC 6.391 0 Td (22% )Tj EMC /TD <>BDC 6.456 0 Td (24% )Tj EMC /TD <>BDC 6.467 0 Td (24% )Tj EMC /TD <>BDC 6.348 0 Td (18% )Tj EMC /TH <>BDC 0.002 Tc -36.847 -1.761 Td [(P)3.7 (ar)-2 (es)10.5 (t)-2.6 (h)2 (e)11.3 (si)8.3 (a )]TJ EMC /TD <>BDC 0 Tc 11.435 0 Td (9% )Tj EMC /TD <>BDC 6.141 0 Td (48% )Tj EMC /TD <>BDC 6.456 0 Td (39% )Tj EMC /TD <>BDC 6.467 0 Td (17% )Tj EMC /TD <>BDC 6.348 0 Td (11% )Tj EMC /TH <>BDC 0.002 Tc -36.847 -1.75 Td [(D)6.6 (ep)2 (r)-2 (es)10.6 (si)-2.6 (o)12.9 (n )]TJ EMC /TD <>BDC 0 Tc 11.435 0 Td (6% )Tj EMC /TD <>BDC 6.141 0 Td (12% )Tj EMC /TD <>BDC 6.456 0 Td (13% )Tj EMC /TD <>BDC 6.467 0 Td (20% )Tj EMC /TD <>BDC 6.348 0 Td (12% )Tj EMC /TH <>BDC 0.002 Tc -0.013 Tw -36.847 -1.761 Td [(P)3.7 (er)-2 (i)-2.6 (p)12.9 (h)2 (er)9 (al)-2.6 ( n)2 (eu)2 (r)8.9 (i)8.3 (t)-2.6 (i)-2.6 (s )]TJ EMC /TD <>BDC 0 Tc 0 Tw 11.435 0 Td (2% )Tj EMC /TD <>BDC 6.141 0 Td (23% )Tj EMC /TD <>BDC 6.456 0 Td (16% )Tj EMC /TD <>BDC 6.717 0 Td (2% )Tj EMC /TD <>BDC 6.348 0 Td (2% )Tj EMC /TH <>BDC -37.097 -1.761 Td [(N)4.6 (e)-1.6 (ur)-4 (opa)9.2 (t)-4.6 (hy )]TJ EMC /TD <>BDC 11.435 0 Td (1% )Tj EMC /TD <>BDC 6.141 0 Td (13% )Tj EMC /TD <>BDC 6.706 0 Td (5% )Tj EMC /TD <>BDC 6.467 0 Td (4% )Tj EMC /TD <>BDC 6.348 0 Td (4% )Tj EMC /TH <>BDC 0.002 Tc -38.184 -1.75 Td [(R)6 (esp)2 (i)8.3 (r)-2 (at)8.3 (o)2 (r)-1.9 (y )]TJ EMC /TH <>BDC 0 Tc 1.087 -1.761 Td [(C)4 (oug)10.8 (h i)-4.6 (nc)-1.6 (r)-4 (e)9.2 (a)-1.6 (s)-2.3 (e)-1.7 (d )]TJ EMC /TD <>BDC 11.185 0 Td (26% )Tj EMC /TD <>BDC 6.391 0 Td (41% )Tj EMC /TD <>BDC 6.456 0 Td (22% )Tj EMC /TD <>BDC 6.467 0 Td (43% )Tj EMC /TD <>BDC 6.348 0 Td (29% )Tj EMC /TH <>BDC -36.847 -1.761 Td [(D)4.6 (y)10.9 (s)-2.3 (pne)-1.7 (a )]TJ EMC /TD <>BDC 11.185 0 Td (22% )Tj EMC /TD <>BDC 6.391 0 Td (27% )Tj EMC /TD <>BDC 6.456 0 Td (26% )Tj EMC /TD <>BDC 6.467 0 Td (42% )Tj EMC /TD <>BDC 6.348 0 Td (25% )Tj EMC /TH <>BDC -0.006 Tc -36.847 -1.75 Td [(R)-2 (h)-6 (i)-10.6 (n)-6 (it)-10.6 (is )]TJ EMC /TD <>BDC 0 Tc 11.185 0 Td (14% )Tj EMC /TD <>BDC 6.391 0 Td (22% )Tj EMC /TD <>BDC 6.706 0 Td (5% )Tj EMC /TD <>BDC 6.217 0 Td (22% )Tj EMC /TD <>BDC 6.348 0 Td (16% )Tj EMC /TH <>BDC 0.005 Tc -36.847 -1.761 Td [(P)6.7 (h)5 (a)3.3 (r)1.1 (y)15.8 (n)5 (g)15.9 (itis )]TJ EMC /TD <>BDC 0 Tc 11.184 0 Td (12% )Tj EMC /TD <>BDC 6.391 0 Td (22% )Tj EMC /TD <>BDC 6.456 0 Td (14% )Tj EMC /TD <>BDC 6.467 0 Td (30% )Tj EMC /TD <>BDC 6.348 0 Td (18% )Tj EMC /TH <>BDC 0.005 Tc -36.846 -1.761 Td [(S)6.7 (in)5 (u)5.1 (s)13.5 (it)11.3 (is )]TJ EMC /TD <>BDC 0 Tc 11.435 0 Td (9% )Tj EMC /TD <>BDC 6.141 0 Td (21% )Tj EMC /TD <>BDC 6.706 0 Td (7% )Tj EMC /TD <>BDC 6.217 0 Td (13% )Tj EMC /TD <>BDC 6.598 0 Td (6% )Tj EMC /TH <>BDC -0.011 Tc -38.184 -1.75 Td [(S)-9.3 (ki)-15.6 (n )]TJ EMC /TH <>BDC 0.002 Tc 1.087 -1.761 Td [(R)6 (ash )]TJ EMC /TD <>BDC 0 Tc 11.185 0 Td (18% )Tj EMC /TD <>BDC 6.391 0 Td (38% )Tj EMC /TD <>BDC 6.456 0 Td (18% )Tj EMC /TD <>BDC 6.467 0 Td (27% )Tj EMC /TD <>BDC 6.348 0 Td (17% )Tj EMC /TH <>BDC 0.002 Tc -0.013 Tw -36.847 -1.761 Td [(H)6.6 (er)-2 (p)2 (es si)-2.6 (m)19.1 (p)2 (l)-2.6 (ex )]TJ EMC /TD <>BDC 0 Tc 0 Tw 11.435 0 Td (2% )Tj EMC /TD <>BDC 6.141 0 Td (12% )Tj EMC /TD <>BDC 6.706 0 Td (3% )Tj EMC /TD <>BDC 6.467 0 Td (7% )Tj EMC /TD <>BDC 6.348 0 Td (9% )Tj EMC /TH <>BDC -0.005 Tc -37.097 -1.75 Td [(Ac)-6.7 (n)-5 (e )]TJ EMC /TD <>BDC 0 Tc 11.435 0 Td (2% )Tj EMC /TD <>BDC 6.141 0 Td (11% )Tj EMC /TD <>BDC 6.706 0 Td (3% )Tj EMC /TD <>BDC 6.467 0 Td (3% )Tj EMC /TD <>BDC 5.946 0 Td [(< )-1 (1% )]TJ EMC /TH <>BDC -37.782 -1.761 Td [(U)4.6 (r)-3.9 (og)10.8 (e)-1.6 (ni)-4.6 (t)-4.6 (a)9.2 (l )]TJ EMC ET /TH <>BDC q 1 0 0 1 20.634735 18.705933 cm 72.72 235.92 117.12 31.2 re W n 1 0 0 1 -20.634735 -18.705933 cm BT 0.004 Tc 3.485 Tw 11.04 0 0 11.04 110.3947 272.6259 Tm [(U)8.6 (ri)-0.7 (n)4 (a)13.3 (ry)14.9 ( t)-0.6 (ra)2.3 (c)13.2 (t )]TJ ET Q BT 11.04 0 0 11.04 110.3947 259.9059 Tm [(i)-4.6 (nf)-4 (e)9.3 (c)-1.7 (t)6.3 (i)-4.6 (on )]TJ ET EMC BT /TD <>BDC 11.04 0 0 11.04 236.6347 266.2659 Tm (5% )Tj EMC /TD <>BDC 6.141 0 Td (18% )Tj EMC /TD <>BDC 6.456 0 Td (14% )Tj EMC /TD <>BDC 6.467 0 Td (13% )Tj EMC /TD <>BDC 6.598 0 Td (7% )Tj EMC /StyleSpan <>BDC 6.48 0 0 6.48 92.6347 248.0259 Tm (a )Tj EMC /P <>BDC 0.002 Tc 0.001 Tw 9.96 0 0 9.96 98.0346 244.5459 Tm [(D)1.1 (at)2.9 (a f)9.7 (o)-4 (r )]TJ -0.001 Tc 3.567 0 Td [(tr)-5.3 (a)-2.8 (s)2.4 (tu)5 (z)-14.8 (u)-7 (m)5.9 (a)-2.8 (b )]TJ 0.006 Tc -0.003 Tw 5.156 0 Td [(s)9.5 (i)6.8 (ng)12 (l)6.9 (e )-7.8 (a)4.2 (g)12 (e)4.2 (n)12 (t )-5.1 (w)17.1 (e)4.2 (r)1.7 (e )-7.9 (f)13.7 (r)1.7 (o)-12.1 (m)24.9 ( 4 s)9.4 (t)-5.1 (u)12 (di)6.8 (e)4.3 (s)9.4 (,)3 ( i)6.9 (n)12 (c)-7.8 (l)6.8 (u)12.1 (di)6.9 (ng)12 ( 213 pa)4.2 (t)6.9 (i)6.9 (e)4.2 (n)12 (t)6.9 (s)9.4 ( f)13.7 (r)1.7 (o)-12.1 (m)12.9 ( S)7.7 (t)-5.1 (u)12 (dy)12 ( 6. )]TJ EMC /StyleSpan <>BDC 0 Tc 0 Tw 6.48 0 0 6.48 92.6347 236.5059 Tm (b )Tj EMC /P <>BDC 0.006 Tc -0.003 Tw 9.96 0 0 9.96 98.3946 233.0259 Tm [(A)5.1 (n)12 (t)-5.1 (h)12 (r)1.6 (a)4.3 (c)-7.9 (y)24.1 (c)4.2 (l)6.9 (i)-5.2 (n)12 (e)4.3 ( \()1.7 (dox)12 (or)1.7 (u)12 (bi)6.9 (c)4.2 (i)6.9 (n or)1.6 ( e)4.2 (pi)6.9 (r)1.6 (u)12.1 (bi)6.9 (c)4.2 (i)6.9 (n)12 (\))1.7 ( a)4.2 (n)12 (d c)-7.8 (y)24.1 (c)4.2 (l)6.9 (oph)12 (os)9.5 (ph)12 (a)-7.9 (m)12.9 (i)6.9 (de)]TJ 0 Tc 0 Tw 26.337 0 Td (. )Tj EMC /P <>BDC 12 0 0 12 92.6347 207.4659 Tm [(T)1 (he)4 ( f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng)10 ( s)-1 (ubs)-11 (e)4 (c)4 (t)-2 (i)-2 (on)-10 (s)-1 ( pr)3 (ovi)-2 (de)4 ( a)4 (ddi)-2 (t)-2 (i)-2 (ona)4 (l)-2 ( de)4 (t)-2 (a)4 (i)-12 (l)-2 ( r)3 (e)4 (ga)4 (r)3 (di)-2 (n)-10 (g)10 ( a)4 (dv)-10 (e)4 (r)3 (s)-1 (e )-6 (r)3 (e)4 (a)-6 (c)4 (t)-2 (i)-2 (ons)-1 ( obs)-1 (e)4 (r)3 (ve)4 (d i)-2 (n )]TJ 0.002 Tc -0.002 Tw 0 -1.17 TD [(c)6 (lin)2 (ic)6 (a)6 (l tr)5 (ia)6 (ls)1 ( o)2 (f)5 ( a)6 (d)2 (ju)2 (v)2 (a)6 (n)2 (t )-10 (b)2 (r)5 (e)6 (a)6 (s)1 (t )]TJ -0.004 Tc 0.004 Tw [(an)-4 (d )-4 (m)-6 (et)-16 (as)-5 (t)-6 (at)-6 (i)-6 (c b)-4 (r)-1 (e)-10 (as)-5 (t)-6 ( can)-4 (c)-10 (er)-1 (,)-4 ( o)-4 (r)-1 ( p)-3.9 (o)-4 (s)-5 (t)]TJ 0 Tc 0 Tw 27.34 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.33 0 Td [(m)-6 (a)-10 (r)-1 (k)-4 (e)-10 (t)-6 (i)-6 (n)-4 (g)6 ( ex)-14 (p)-4 (er)-1 (i)-6 (en)-4 (c)-10 (e. )]TJ EMC /P <>BDC /TT2 1 Tf 0 Tc 0 Tw -27.67 -1.67 Td [(C)-3 (ar)-1 (di)-2 (om)2 (y)4 (opat)-2 (hy )]TJ EMC /Span <>BDC /TT0 1 Tf 0.002 Tc -0.002 Tw 0 -1.66 TD [(S)-2 (e)6 (r)5 (ia)6 (l me)6 (a)6 (s)1 (u)2 (r)5 (e)6 (m)-10 (e)6 (n)2 (t o)2 (f)5 ( c)-4 (a)-4 (r)5 (d)2 (ia)6 (c)6 ( f)5 (u)2 (n)-8 (c)6 (tio)2 (n)2 ( \()-5 (L)13 (V)4 (E)3 (F)-2 (\))5 ( w)-6 (a)5.9 (s)1 ( o)2 (b)2 (ta)5.9 (in)2 (e)6.1 (d)1.9 ( in)2 ( c)6 (lin)2 (ic)6 (a)6 (l tr)5 (i)-10 (a)6 (ls)1 ( in)2 ( th)2 (e)6 ( a)6 (d)2 (ju)2 (v)2 (a)6 (n)2 (t )]TJ 0 Tc 0 Tw 0 -1.17 TD [(t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( of)3 ( br)-7 (e)4 (a)4 (s)-1 (t)-2 ( c)4 (a)4 (n)-10 (c)4 (e)-6 (r)3 (. )-10 (I)13 (n S)-4 (t)-2 (udi)-2 (e)4 (s)-1 ( 1 a)4 (nd 2, t)-2 (he )-6 (m)-2 (e)4 (di)-2 (a)4 (n dur)3 (a)4 (t)-2 (i)-2 (on of)3 ( f)3 (ol)-2 (l)-2 (o)-10 (w)2 (-)3 (up w)2 (a)4 (s )-1 (7.9 )-20 (y)20 (e)-6 (a)4 (r)3 (s)-1 ( i)-2 (n )]TJ -0.004 Tc 0.004 Tw 0 -1.16 TD [(t)-6 (h)-4 (e A)-2 (C)]TJ 0 Tc 0 Tw 2.86 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.33 0 Td [(T)-3 ( ar)-1 (m )-6 (an)-4 (d )]TJ 0 Tc 0 Tw 4.35 0 Td [(8.3 )-20 (y)20 (e)-16 (a)4 (r)3 (s)-1 ( i)-2 (n t)-2 (he)4 ( A)2 (C)-3 (-)]TJ 0.01 Tw 8.09 0 Td [(T)1 (H)2 ( a)4 (r)3 (m)-2 (. 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This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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0.72 re f 72 453.24 0.72 18.6 re f 189.84 453.24 0.72 18.6 re f 256.32 453.24 0.72 18.6 re f 330.72 453.24 0.72 18.6 re f 399 453.24 0.72 18.6 re f 473.4 453.24 0.72 18.6 re f 539.28 453.24 0.72 18.6 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 173.4575 456.0386 Tm ( )Tj 7.5 0 Td ( )Tj 6.391 0 Td ( )Tj 6.206 0 Td ( )Tj 6.717 0 Td ( )Tj 6.098 0 Td ( )Tj ET Q 72 452.52 0.72 0.72 re f 72.72 452.52 117.12 0.72 re f 189.84 452.52 0.72 0.72 re f 190.56 452.52 65.76 0.72 re f 256.32 452.52 0.72 0.72 re f 257.04 452.52 73.68 0.72 re f 330.72 452.52 0.72 0.72 re f 331.44 452.52 67.559 0.72 re f 399 452.52 0.72 0.72 re f 399.72 452.52 73.68 0.72 re f 473.4 452.52 0.72 0.72 re f 474.12 452.52 65.16 0.72 re f 539.28 452.52 0.72 0.72 re f 72 433.8 0.72 18.72 re f 189.84 433.8 0.72 18.72 re f 256.32 433.8 0.72 18.72 re f 330.72 433.8 0.72 18.72 re f 399 433.8 0.72 18.72 re f 473.4 433.8 0.72 18.72 re f 539.28 433.8 0.72 18.72 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 189.2999 436.5986 Tm ( )Tj 5.815 0 Td ( )Tj 6.641 0 Td ( )Tj 6.206 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 433.08 0.72 0.72 re f 72.72 433.08 117.12 0.72 re f 189.84 433.08 0.72 0.72 re f 190.56 433.08 65.76 0.72 re f 256.32 433.08 0.72 0.72 re f 257.04 433.08 73.68 0.72 re f 330.72 433.08 0.72 0.72 re f 331.44 433.08 67.559 0.72 re f 399 433.08 0.72 0.72 re f 399.72 433.08 73.68 0.72 re f 473.4 433.08 0.72 0.72 re f 474.12 433.08 65.16 0.72 re f 539.28 433.08 0.72 0.72 re f 72 414.36 0.72 18.72 re f 189.84 414.36 0.72 18.72 re f 256.32 414.36 0.72 18.72 re f 330.72 414.36 0.72 18.72 re f 399 414.36 0.72 18.72 re f 473.4 414.36 0.72 18.72 re f 539.28 414.36 0.72 18.72 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 186.7718 417.1586 Tm ( )Tj 6.043 0 Td ( )Tj 6.391 0 Td ( )Tj 6.456 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 413.64 0.72 0.72 re f 72.72 413.64 117.12 0.72 re f 189.84 413.64 0.72 0.72 re f 190.56 413.64 65.76 0.72 re f 256.32 413.64 0.72 0.72 re f 257.04 413.64 73.68 0.72 re f 330.72 413.64 0.72 0.72 re f 331.44 413.64 67.559 0.72 re f 399 413.64 0.72 0.72 re f 399.72 413.64 73.68 0.72 re f 473.4 413.64 0.72 0.72 re f 474.12 413.64 65.16 0.72 re f 539.28 413.64 0.72 0.72 re f 72 395.04 0.72 18.6 re f 189.84 395.04 0.72 18.6 re f 256.32 395.04 0.72 18.6 re f 330.72 395.04 0.72 18.6 re f 399 395.04 0.72 18.6 re f 473.4 395.04 0.72 18.6 re f 539.28 395.04 0.72 18.6 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 167.2204 397.8386 Tm ( )Tj ET Q 77.76 379.32 66.6 0.48 re f q 190.2 375.6 66.48 18.72 re W n q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 246.1761 401.7987 Tm ( )Tj ET Q Q q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 316.7361 397.8386 Tm ( )Tj 6.457 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 394.32 0.72 0.72 re f 72.72 394.32 117.12 0.72 re f 189.84 394.32 0.72 0.72 re f 190.56 394.32 0.72 0.72 re f 191.28 394.32 65.04 0.72 re f 256.32 394.32 0.72 0.72 re f 257.04 394.32 0.72 0.72 re f 257.76 394.32 72.96 0.72 re f 330.72 394.32 0.72 0.72 re f 331.44 394.32 0.72 0.72 re f 332.16 394.32 66.839 0.72 re f 399 394.32 0.72 0.72 re f 399.72 394.32 0.72 0.72 re f 400.44 394.32 72.96 0.72 re f 473.4 394.32 0.72 0.72 re f 474.12 394.32 0.72 0.72 re f 474.84 394.32 64.44 0.72 re f 539.28 394.32 0.72 0.72 re f 72 375.6 0.72 18.72 re f 539.28 375.6 0.72 18.72 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 166.9771 378.3986 Tm ( )Tj 7.837 0 Td ( )Tj 6.641 0 Td ( )Tj 6.206 0 Td ( )Tj 6.717 0 Td ( )Tj 6.098 0 Td ( )Tj ET Q 72 374.88 0.72 0.72 re f 72.72 374.88 117.12 0.72 re f 189.84 374.88 0.72 0.72 re f 190.56 374.88 0.72 0.72 re f 191.28 374.88 65.04 0.72 re f 256.32 374.88 0.72 0.72 re f 257.04 374.88 0.72 0.72 re f 257.76 374.88 72.96 0.72 re f 330.72 374.88 0.72 0.72 re f 331.44 374.88 0.72 0.72 re f 332.16 374.88 66.839 0.72 re f 399 374.88 0.72 0.72 re f 399.72 374.88 0.72 0.72 re f 400.44 374.88 72.96 0.72 re f 473.4 374.88 0.72 0.72 re f 474.12 374.88 0.72 0.72 re f 474.84 374.88 64.44 0.72 re f 539.28 374.88 0.72 0.72 re f 72 356.16 0.72 18.72 re f 189.84 356.16 0.72 18.72 re f 256.32 356.16 0.72 18.72 re f 330.72 356.16 0.72 18.72 re f 399 356.16 0.72 18.72 re f 473.4 356.16 0.72 18.72 re f 539.28 356.16 0.72 18.72 re f q 72.72 324.12 117.12 31.32 re W n q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 0.002 Tc 1.889 Tw 3 Tr 11.04 0 0 11.04 207.666 359.0787 Tm ( )Tj ET Q Q q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 141.298 346.3587 Tm ( )Tj 10.163 0.576 Td ( )Tj 6.641 0 Td ( )Tj 6.206 0 Td ( )Tj 6.717 0 Td ( )Tj 6.098 0 Td ( )Tj ET Q 72 355.44 0.72 0.72 re f 72.72 355.44 117.12 0.72 re f 189.84 355.44 0.72 0.72 re f 190.56 355.44 65.76 0.72 re f 256.32 355.44 0.72 0.72 re f 257.04 355.44 73.68 0.72 re f 330.72 355.44 0.72 0.72 re f 331.44 355.44 67.559 0.72 re f 399 355.44 0.72 0.72 re f 399.72 355.44 73.68 0.72 re f 473.4 355.44 0.72 0.72 re f 474.12 355.44 65.16 0.72 re f 539.28 355.44 0.72 0.72 re f 72 324.12 0.72 31.32 re f 189.84 324.12 0.72 31.32 re f 256.32 324.12 0.72 31.32 re f 330.72 324.12 0.72 31.32 re f 399 324.12 0.72 31.32 re f 473.4 324.12 0.72 31.32 re f 539.28 324.12 0.72 31.32 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 142.7337 326.9186 Tm ( )Tj ET Q 77.76 308.4 42.12 0.48 re f q 190.2 304.8 66.48 18.599 re W n q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 246.1761 330.8786 Tm ( )Tj ET Q Q q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 316.7361 326.9186 Tm ( )Tj 6.457 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 323.4 0.72 0.72 re f 72.72 323.4 117.12 0.72 re f 189.84 323.4 0.72 0.72 re f 190.56 323.4 0.72 0.72 re f 191.28 323.4 65.04 0.72 re f 256.32 323.4 0.72 0.72 re f 257.04 323.4 0.72 0.72 re f 257.76 323.4 72.96 0.72 re f 330.72 323.4 0.72 0.72 re f 331.44 323.4 0.72 0.72 re f 332.16 323.4 66.839 0.72 re f 399 323.4 0.72 0.72 re f 399.72 323.4 0.72 0.72 re f 400.44 323.4 72.96 0.72 re f 473.4 323.4 0.72 0.72 re f 474.12 323.4 0.72 0.72 re f 474.84 323.4 64.44 0.72 re f 539.28 323.4 0.72 0.72 re f 72 304.8 0.72 18.599 re f 539.28 304.8 0.72 18.599 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 145.0185 307.5986 Tm ( )Tj 10.076 0 Td ( )Tj 6.391 0 Td ( )Tj 6.206 0 Td ( )Tj 6.717 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 304.08 0.72 0.72 re f 72.72 304.08 117.12 0.72 re f 189.84 304.08 0.72 0.72 re f 190.56 304.08 0.72 0.72 re f 191.28 304.08 65.04 0.72 re f 256.32 304.08 0.72 0.72 re f 257.04 304.08 0.72 0.72 re f 257.76 304.08 72.96 0.72 re f 330.72 304.08 0.72 0.72 re f 331.44 304.08 0.72 0.72 re f 332.16 304.08 66.839 0.72 re f 399 304.08 0.72 0.72 re f 399.72 304.08 0.72 0.72 re f 400.44 304.08 72.96 0.72 re f 473.4 304.08 0.72 0.72 re f 474.12 304.08 0.72 0.72 re f 474.84 304.08 64.44 0.72 re f 539.28 304.08 0.72 0.72 re f 72 285.36 0.72 18.72 re f 189.84 285.36 0.72 18.72 re f 256.32 285.36 0.72 18.72 re f 330.72 285.36 0.72 18.72 re f 399 285.36 0.72 18.72 re f 473.4 285.36 0.72 18.72 re f 539.28 285.36 0.72 18.72 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 151.1347 288.1586 Tm ( )Tj 9.522 0 Td ( )Tj 6.391 0 Td ( )Tj 6.456 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 284.64 0.72 0.72 re f 72.72 284.64 117.12 0.72 re f 189.84 284.64 0.72 0.72 re f 190.56 284.64 65.76 0.72 re f 256.32 284.64 0.72 0.72 re f 257.04 284.64 73.68 0.72 re f 330.72 284.64 0.72 0.72 re f 331.44 284.64 67.559 0.72 re f 399 284.64 0.72 0.72 re f 399.72 284.64 73.68 0.72 re f 473.4 284.64 0.72 0.72 re f 474.12 284.64 65.16 0.72 re f 539.28 284.64 0.72 0.72 re f 72 265.92 0.72 18.72 re f 189.84 265.92 0.72 18.72 re f 256.32 265.92 0.72 18.72 re f 330.72 265.92 0.72 18.72 re f 399 265.92 0.72 18.72 re f 473.4 265.92 0.72 18.72 re f 539.28 265.92 0.72 18.72 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 154.7337 268.7186 Tm ( )Tj 9.196 0 Td ( )Tj 6.391 0 Td ( )Tj 6.456 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 265.2 0.72 0.72 re f 72.72 265.2 117.12 0.72 re f 189.84 265.2 0.72 0.72 re f 190.56 265.2 65.76 0.72 re f 256.32 265.2 0.72 0.72 re f 257.04 265.2 73.68 0.72 re f 330.72 265.2 0.72 0.72 re f 331.44 265.2 67.559 0.72 re f 399 265.2 0.72 0.72 re f 399.72 265.2 73.68 0.72 re f 473.4 265.2 0.72 0.72 re f 474.12 265.2 65.16 0.72 re f 539.28 265.2 0.72 0.72 re f 72 246.6 0.72 18.6 re f 189.84 246.6 0.72 18.6 re f 256.32 246.6 0.72 18.6 re f 330.72 246.6 0.72 18.6 re f 399 246.6 0.72 18.6 re f 473.4 246.6 0.72 18.6 re f 539.28 246.6 0.72 18.6 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 206.0918 249.3986 Tm [( )-4043 ( )]TJ 10.934 0 Td ( )Tj 6.456 0 Td ( )Tj 6.467 0 Td ( )Tj 6.098 0 Td ( )Tj ET Q 72 245.88 0.72 0.72 re f 72.72 245.88 117.12 0.72 re f 189.84 245.88 0.72 0.72 re f 190.56 245.88 65.76 0.72 re f 256.32 245.88 0.72 0.72 re f 257.04 245.88 73.68 0.72 re f 330.72 245.88 0.72 0.72 re f 331.44 245.88 67.559 0.72 re f 399 245.88 0.72 0.72 re f 399.72 245.88 73.68 0.72 re f 473.4 245.88 0.72 0.72 re f 474.12 245.88 65.16 0.72 re f 539.28 245.88 0.72 0.72 re f 72 227.16 0.72 18.72 re f 189.84 227.16 0.72 18.72 re f 256.32 227.16 0.72 18.72 re f 330.72 227.16 0.72 18.72 re f 399 227.16 0.72 18.72 re f 473.4 227.16 0.72 18.72 re f 539.28 227.16 0.72 18.72 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 153.5414 229.9586 Tm ( )Tj 9.304 0 Td ( )Tj 6.391 0 Td ( )Tj 6.456 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 226.44 0.72 0.72 re f 72.72 226.44 117.12 0.72 re f 189.84 226.44 0.72 0.72 re f 190.56 226.44 65.76 0.72 re f 256.32 226.44 0.72 0.72 re f 257.04 226.44 73.68 0.72 re f 330.72 226.44 0.72 0.72 re f 331.44 226.44 67.559 0.72 re f 399 226.44 0.72 0.72 re f 399.72 226.44 73.68 0.72 re f 473.4 226.44 0.72 0.72 re f 474.12 226.44 65.16 0.72 re f 539.28 226.44 0.72 0.72 re f 72 207.72 0.72 18.72 re f 189.84 207.72 0.72 18.72 re f 256.32 207.72 0.72 18.72 re f 330.72 207.72 0.72 18.72 re f 399 207.72 0.72 18.72 re f 473.4 207.72 0.72 18.72 re f 539.28 207.72 0.72 18.72 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 188.5718 210.5186 Tm ( )Tj ET Q 77.76 192 87.96 0.481 re f q 190.2 188.4 66.48 18.6 re W n q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 246.1761 214.5986 Tm ( )Tj ET Q Q q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 316.7361 210.5186 Tm ( )Tj 6.457 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 207 0.72 0.72 re f 72.72 207 117.12 0.72 re f 189.84 207 0.72 0.72 re f 190.56 207 0.72 0.72 re f 191.28 207 65.04 0.72 re f 256.32 207 0.72 0.72 re f 257.04 207 0.72 0.72 re f 257.76 207 72.96 0.72 re f 330.72 207 0.72 0.72 re f 331.44 207 0.72 0.72 re f 332.16 207 66.839 0.72 re f 399 207 0.72 0.72 re f 399.72 207 0.72 0.72 re f 400.44 207 72.96 0.72 re f 473.4 207 0.72 0.72 re f 474.12 207 0.72 0.72 re f 474.84 207 64.44 0.72 re f 539.28 207 0.72 0.72 re f 72 188.4 0.72 18.6 re f 539.28 188.4 0.72 18.6 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 147.4142 191.1986 Tm ( )Tj 9.609 0 Td ( )Tj 6.641 0 Td ( )Tj 6.206 0 Td ( )Tj 6.717 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 187.68 0.72 0.72 re f 72.72 187.68 117.12 0.72 re f 189.84 187.68 0.72 0.72 re f 190.56 187.68 0.72 0.72 re f 191.28 187.68 65.04 0.72 re f 256.32 187.68 0.72 0.72 re f 257.04 187.68 0.72 0.72 re f 257.76 187.68 72.96 0.72 re f 330.72 187.68 0.72 0.72 re f 331.44 187.68 0.72 0.72 re f 332.16 187.68 66.839 0.72 re f 399 187.68 0.72 0.72 re f 399.72 187.68 0.72 0.72 re f 400.44 187.68 72.96 0.72 re f 473.4 187.68 0.72 0.72 re f 474.12 187.68 0.72 0.72 re f 474.84 187.68 64.44 0.72 re f 539.28 187.68 0.72 0.72 re f 72 168.96 0.72 18.72 re f 189.84 168.96 0.72 18.72 re f 256.32 168.96 0.72 18.72 re f 330.72 168.96 0.72 18.72 re f 399 168.96 0.72 18.72 re f 473.4 168.96 0.72 18.72 re f 539.28 168.96 0.72 18.72 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 164.5814 171.7586 Tm ( )Tj 8.054 0 Td ( )Tj 6.641 0 Td ( )Tj 6.456 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 168.24 0.72 0.72 re f 72.72 168.24 117.12 0.72 re f 189.84 168.24 0.72 0.72 re f 190.56 168.24 65.76 0.72 re f 256.32 168.24 0.72 0.72 re f 257.04 168.24 73.68 0.72 re f 330.72 168.24 0.72 0.72 re f 331.44 168.24 67.559 0.72 re f 399 168.24 0.72 0.72 re f 399.72 168.24 73.68 0.72 re f 473.4 168.24 0.72 0.72 re f 474.12 168.24 65.16 0.72 re f 539.28 168.24 0.72 0.72 re f 72 149.64 0.72 18.599 re f 189.84 149.64 0.72 18.599 re f 256.32 149.64 0.72 18.599 re f 330.72 149.64 0.72 18.599 re f 399 149.64 0.72 18.599 re f 473.4 149.64 0.72 18.599 re f 539.28 149.64 0.72 18.599 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 145.2508 152.3186 Tm ( )Tj ET Q 77.76 133.8 44.64 0.48 re f q 190.2 130.2 66.48 18.599 re W n q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 246.1761 156.3986 Tm ( )Tj ET Q Q q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 316.7361 152.3186 Tm ( )Tj 6.457 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 148.92 0.72 0.72 re f 72.72 148.92 117.12 0.72 re f 189.84 148.92 0.72 0.72 re f 190.56 148.92 0.72 0.72 re f 191.28 148.92 65.04 0.72 re f 256.32 148.92 0.72 0.72 re f 257.04 148.92 0.72 0.72 re f 257.76 148.92 72.96 0.72 re f 330.72 148.92 0.72 0.72 re f 331.44 148.92 0.72 0.72 re f 332.16 148.92 66.839 0.72 re f 399 148.92 0.72 0.72 re f 399.72 148.92 0.72 0.72 re f 400.44 148.92 72.96 0.72 re f 473.4 148.92 0.72 0.72 re f 474.12 148.92 0.72 0.72 re f 474.84 148.92 64.44 0.72 re f 539.28 148.92 0.72 0.72 re f 72 130.2 0.72 18.72 re f 539.28 130.2 0.72 18.72 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 189.3163 132.9986 Tm ( )Tj 6.064 0 Td ( )Tj 6.391 0 Td ( )Tj 6.456 0 Td ( )Tj 6.467 0 Td ( )Tj 6.348 0 Td ( )Tj ET Q 72 129.48 0.72 0.72 re f 72.72 129.48 117.12 0.72 re f 189.84 129.48 0.72 0.72 re f 190.56 129.48 0.72 0.72 re f 191.28 129.48 65.04 0.72 re f 256.32 129.48 0.72 0.72 re f 257.04 129.48 0.72 0.72 re f 257.76 129.48 72.96 0.72 re f 330.72 129.48 0.72 0.72 re f 331.44 129.48 0.72 0.72 re f 332.16 129.48 66.839 0.72 re f 399 129.48 0.72 0.72 re f 399.72 129.48 0.72 0.72 re f 400.44 129.48 72.96 0.72 re f 473.4 129.48 0.72 0.72 re f 474.12 129.48 0.72 0.72 re f 474.84 129.48 64.44 0.72 re f 539.28 129.48 0.72 0.72 re f 72 110.76 0.72 18.72 re f 189.84 110.76 0.72 18.72 re f 256.32 110.76 0.72 18.72 re f 330.72 110.76 0.72 18.72 re f 399 110.76 0.72 18.72 re f 473.4 110.76 0.72 18.72 re f 539.28 110.76 0.72 18.72 re f q 1 0 0 1 -22.85614 -16.838623 cm BT /TT0 1 Tf 3 Tr 11.04 0 0 11.04 143.219 113.5586 Tm ( )Tj 9.989 0 Td ( )Tj 6.641 0 Td ( )Tj 6.206 0 Td ( )Tj 6.717 0 Td ( )Tj 6.098 0 Td ( )Tj ET Q 72 110.04 0.72 0.72 re f 72.72 110.04 117.12 0.72 re f 189.84 110.04 0.72 0.72 re f 190.56 110.04 65.76 0.72 re f 256.32 110.04 0.72 0.72 re f 257.04 110.04 73.68 0.72 re f 330.72 110.04 0.72 0.72 re f 331.44 110.04 67.559 0.72 re f 399 110.04 0.72 0.72 re f 399.72 110.04 73.68 0.72 re f 473.4 110.04 0.72 0.72 re f 474.12 110.04 65.16 0.72 re f 539.28 110.04 0.72 0.72 re f 72 91.32 0.72 18.72 re f 72 90.6 0.72 0.72 re f 72 90.6 0.72 0.72 re f 72.72 90.6 117.12 0.72 re f 189.84 91.32 0.72 18.72 re f 189.84 90.6 0.72 0.72 re f 190.56 90.6 65.76 0.72 re f 256.32 91.32 0.72 18.72 re f 256.32 90.6 0.72 0.72 re f 257.04 90.6 73.68 0.72 re f 330.72 91.32 0.72 18.72 re f 330.72 90.6 0.72 0.72 re f 331.44 90.6 67.559 0.72 re f 399 91.32 0.72 18.72 re f 399 90.6 0.72 0.72 re f 399.72 90.6 73.68 0.72 re f 473.4 91.32 0.72 18.72 re f 473.4 90.6 0.72 0.72 re f 474.12 90.6 65.16 0.72 re f 539.28 91.32 0.72 18.72 re f 539.28 90.6 0.72 0.72 re f 539.28 90.6 0.72 0.72 re f EMC 1 0 0 1 -22.85614 -16.838623 cm BT /P <>BDC /TT1 1 Tf 12 0 0 12 94.8561 725.4386 Tm [(T)-3 (ab)-4 (l)-2 (e )4 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/TD <>BDC 6.467 0 Td (56% )Tj EMC /TD <>BDC 6.348 0 Td (34% )Tj EMC /TH <>BDC 0.005 Tc -36.847 -1.75 Td [(C)9 (h)5 (il)11.2 (ls )]TJ EMC /TD <>BDC 0 Tc 11.184 0 Td (32% )Tj EMC /TD <>BDC 6.391 0 Td (41% )Tj EMC /TD <>BDC 6.706 0 Td (4% )Tj EMC /TD <>BDC 6.217 0 Td (35% )Tj EMC /TD <>BDC 6.348 0 Td (11% )Tj EMC /TH <>BDC 0.002 Tc -36.846 -1.761 Td [(H)6.6 (ead)2 (ach)12.9 (e )]TJ EMC /TD <>BDC 0 Tc 11.185 0 Td (26% )Tj EMC /TD <>BDC 6.391 0 Td (36% )Tj EMC /TD <>BDC 6.456 0 Td (28% )Tj EMC /TD <>BDC 6.467 0 Td (44% )Tj EMC /TD <>BDC 6.348 0 Td (31% )Tj EMC /TH <>BDC -36.847 -1.761 Td [(A)4.6 (bdom)17.1 (i)-4.6 (na)-1.6 (l)-4.6 ( pa)9.2 (i)-4.6 (n )]TJ EMC /TD <>BDC 11.185 0 Td (22% )Tj EMC /TD <>BDC 6.391 0 Td (34% )Tj EMC /TD <>BDC 6.456 0 Td (22% )Tj EMC /TD <>BDC 6.467 0 Td (23% )Tj EMC /TD <>BDC 6.348 0 Td (18% )Tj EMC /TH <>BDC 0.002 Tc -0.002 Tw -36.847 -1.75 Td [(B)6 (ack)12.8 ( p)2 (ai)-2.7 (n )]TJ EMC /TD <>BDC 0 Tc 0 Tw 11.185 0 Td (22% )Tj EMC /TD <>BDC 6.391 0 Td (34% )Tj 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(lle)14.2 (r)1.1 (g)15.8 (ic)3.4 ( r)11.9 (e)3.4 (a)3.3 (c)14.2 (tio)15.9 (n )]TJ EMC /TD <>BDC 0 Tc 0 Tw 11.434 0 Td (3% )Tj EMC /TD <>BDC 6.391 0 Td (8% )Tj EMC /TD <>BDC 6.456 0 Td (2% )Tj EMC /TD <>BDC 6.467 0 Td (4% )Tj EMC /TD <>BDC 6.348 0 Td (2% )Tj EMC /TH <>BDC 0.002 Tc -38.183 -1.75 Td [(C)6 (ar)-2 (d)2 (i)-2.6 (o)2 (v)12.9 (as)10.5 (cu)2 (l)8.2 (ar )]TJ EMC /TH <>BDC 1.087 -1.761 Td [(T)-6.6 (a)11.3 (ch)2 (y)12.9 (car)-2 (d)12.9 (i)-2.6 (a )]TJ EMC /TD <>BDC 0 Tc 11.435 0 Td (5% )Tj EMC /TD <>BDC 6.141 0 Td (12% )Tj EMC /TD <>BDC 6.706 0 Td (4% )Tj EMC /TD <>BDC 6.217 0 Td (10% )Tj EMC /TD <>BDC 6.598 0 Td (5% )Tj EMC ET /TH <>BDC q 1 0 0 1 22.85614 16.838623 cm 72.72 324.12 117.12 31.32 re W n 1 0 0 1 -22.85614 -16.838623 cm BT 0.002 Tc 1.889 Tw 11.04 0 0 11.04 112.6161 359.0787 Tm [(C)6 (o)2 (n)2 (g)12.8 (est)-2.7 (i)-2.6 (v)12.9 (e h)12.8 (ear)8.9 (t )]TJ ET Q BT -0.007 Tc 11.04 0 0 11.04 112.6161 346.3587 Tm [(f)-11 (a)-8.6 (i)-0.8 (l)-11.6 (u)-7 (re )]TJ ET EMC BT /TD 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(Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4687 0 obj <>>>/Resources 4515 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4688 0 obj <> endobj 4689 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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Tf 13.53 0 Td ( )Tj /TT2 1 Tf -25.67 -1.72 Td ( )Tj /TT0 1 Tf 9.06 0 Td ( )Tj /TT3 1 Tf 1.91 0 Td ( )Tj /TT0 1 Tf 13.53 0 Td ( )Tj /TT2 1 Tf -24.5 -1.71 Td ( )Tj /TT0 1 Tf 22.23 0 Td ( )Tj /TT3 1 Tf 1.91 0 Td ( )Tj 10.98 0 Td ( )Tj /TT0 1 Tf -31.77 -1.17 Td ( )Tj -0.004 Tc 0.004 Tw 30.11 -2.83 Td ( )Tj 0 Tc 0 Tw -33.6 -2.33 Td ( )Tj 33.8 0 Td ( )Tj -27.27 -1.17 Td ( )Tj 20.1 0 Td ( )Tj -20.63 -1.17 Td ( )Tj 16.04 0 Td ( )Tj /TT1 1 Tf 14.04 0 0 14.04 111.7707 351.7904 Tm ( )Tj 13.726 0 Td ( )Tj /TT0 1 Tf -0.004 Tc 0.004 Tw 12 0 0 12 335.2076 331.3903 Tm ( )Tj 16.9 0 Td ( )Tj 0.002 Tc -0.002 Tw -14.17 -1.16 Td ( )Tj 7.36 0 Td ( )Tj 7.95 0 Td ( )Tj 0 Tc 0 Tw -28.3 -1.17 Td ( )Tj 5.8 0 Td ( )Tj 10.71 0 Td ( )Tj /TT3 1 Tf -16.67 -1.67 Td ( )Tj /TT0 1 Tf 3.15 0 Td ( )Tj -6.66 -1.66 Td ( )Tj -0.02 Tc 0.02 Tw 11.44 0 Td ( )Tj 0 Tc 0 Tw 5.15 0 Td ( )Tj -0.004 Tc 0.014 Tw 5.99 0 Td ( )Tj 0 Tc 0 Tw 1.75 0 Td ( )Tj -0.004 Tc 0.004 Tw -26.27 -1.17 Td ( )Tj 0 Tc 0 Tw 7.23 0 Td [( )-1440 ( )]TJ 25.3 0 Td ( )Tj -31.24 -1.17 Td ( )Tj -0.4 -2.16 Td ( )Tj 6.01 0 Td [( )-4890 ( )]TJ -0.004 Tc 0.004 Tw 12.33 0 Td ( )Tj 8.82 0 Td [( )-3420 ( )]TJ 0 Tc 0 Tw -26.05 -1.17 Td ( )Tj -0.004 Tc 0.004 Tw 2.83 0 Td ( )Tj 19.8 0 Td ( )Tj 0.006 Tc -0.006 Tw 5.31 0 Td ( )Tj 0 Tc 0 Tw -29.26 -1.17 Td ( )Tj -0.02 Tc 0.02 Tw 19.87 0 Td ( )Tj 0 Tc 0 Tw 5.15 0 Td ( )Tj -0.004 Tc 0.004 Tw -10.21 -1.16 Td ( )Tj -0.02 Tc 0.02 Tw 13.72 0 Td ( )Tj 0 Tc 0 Tw 5.14 0 Td ( )Tj -0.02 Tc 0.02 Tw -18.05 -1.17 Td ( )Tj 0 Tc 0 Tw 5.14 0 Td ( )Tj -0.003 Tc 0.003 Tw 4.02 0 Td ( )Tj 0 Tc 0 Tw 5.56 0 Td ( )Tj -10.21 -1.67 Td [( )-4440 ( )-4760 ( )]TJ -0.004 Tc 0.004 Tw 13.33 0 Td ( )Tj 0 Tc 0 Tw -17.86 -1.16 Td ( )Tj 12.69 0 Td ( )Tj -0.004 Tc 0.004 Tw 5.44 0 Td ( )Tj 0 Tc 0 Tw -33.43 -1.17 Td ( )Tj -0.004 Tc 0.004 Tw 4.44 0 Td ( )Tj 0 Tc 0 Tw 6.72 0 Td ( )Tj 11.75 0 Td [( )-2580 ( )]TJ EMC /Span <>BDC /TT1 1 Tf -0.002 Tc 0 Tr 14.04 0 0 14.04 94.2488 723.3103 Tm [(5)-6.3 (.5 )]TJ EMC /Span <>BDC 0.004 Tc -0.015 Tw 3.846 0 Td [(E)4.3 (x)8.3 (ac)3.6 (e)3.5 (r)3.6 (b)13 (at)12.2 (ion)4.4 ( of )-5.2 (C)8.1 (h)13 (e)3.5 (m)16.5 (ot)3.7 (h)4.4 (e)3.6 (r)3.5 (ap)13 (y)]TJ 0 Tc 0 Tw (-)Tj -0.001 Tc -0.001 Tw 13.735 0 Td [(I)-5.2 (nd)-0.6 (u)-0.6 (c)-1.4 (e)7.1 (d)-0.6 ( N)3.1 (e)-1.5 (ut)-1.4 (r)-1.4 (o)-5.3 (p)-0.6 (e)-1.4 (n)8 (i)3.5 (a )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw 12 0 0 12 94.2488 702.9103 Tm [(I)13 (n )-10 (r)3 (a)4 (ndom)-2 (i)-2 (z)-6 (e)4 (d, c)4 (ont)-2 (r)3 (ol)-2 (l)-2 (e)-6 (d c)4 (l)-2 (i)-2 (ni)-2 (c)4 (a)4 (l)-2 ( t)-2 (r)3 (i)-2 (a)4 (l)-2 (s)-1 (, t)-2 (he)4 ( pe)4 (r)3 (-)]TJ -0.004 Tc 0.004 Tw 19.37 0 Td [(p)-14 (at)-6 (i)-6 (en)-4 (t)-6 ( i)-6 (n)-4 (ci)-6 (d)-4 (en)-4 (ces)-5 ( o)-14 (f)-1 ( N)-2 (C)-16.9 (I)]TJ 0 Tc 0 Tw 10.25 0 Td [(-)-7 (C)-3 (T)1 (C)-3 ( G)2 (r)3 (a)4 (de)4 ( 3 t)-2 (o 4 )]TJ -29.62 -1.16 Td [(ne)4 (ut)-2 (r)3 (ope)4 (ni)-2 (a)4 ( a)4 (nd o)-10 (f)3 ( f)3 (e)4 (b)-10 (r)3 (i)-2 (l)-2 (e)4 ( ne)4 (ut)-2 (r)3 (ope)4 (ni)-2 (a )-6 (w)2 (e)4 (r)-7 (e)4 ( hi)-12 (g)10 (he)-6 (r)3 ( i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( r)3 (e)4 (c)-6 (e)4 (i)-2 (vi)-2 (ng)10 ( t)-2 (r)-7 (a)-6 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b i)-2 (n )]TJ 0 -1.17 TD [(c)4 (om)-2 (bi)-2 (na)4 (t)-2 (i)-2 (on w)2 (i)-2 (t)-2 (h m)-12 (y)20 (e)4 (l)-2 (os)-11 (uppr)3 (e)4 (s)-1 (s)-1 (i)-2 (ve)4 ( c)4 (h)-10 (e)4 (m)-2 (ot)-2 (he)4 (r)3 (a)4 (p)-20 (y)10 ( a)4 (s)-1 ( c)4 (om)-2 (pa)4 (r)-7 (e)4 (d t)-2 (o t)-2 (hos)-1 (e)4 ( w)2 (h)-10 (o r)3 (e)4 (c)4 (e)4 (i)-2 (v)-10 (e)4 (d )]TJ -0.004 Tc 0.004 Tw T* [(ch)-4 (em)-6 (o)-4 (t)-6 (h)-4 (er)-1 (ap)-24 (y )6 (al)-6 (o)-4 (n)-4 (e.)-4 ( T)-3 (h)-14 (e)-9.9 ( i)-6.1 (n)-3.9 (ci)-6.1 (d)-3.9 (en)-4 (ce o)-4 (f)-1 ( s)-15 (ep)-4 (t)-6 (i)-6 (c d)-4 (e)-10 (at)-6 (h)-4 ( w)-2 (as)-5 ( s)-5 (i)-6 (m)-6 (i)-6 (l)-6 (ar)-1 ( am)-6 (o)-4 (n)-4 (g)6 ( p)-14 (at)-6 (i)-6 (e)-10 (n)-4 (t)-6 (s)-4.9 ( w)-2 (h)-4 (o)-4 ( r)-1.1 (ecei)-6 (v)-14 (ed )]TJ 0 Tc 0 Tw T* [(t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b a)4 (nd t)-2 (hos)-1 (e)4 ( w)2 (ho di)-2 (d not )]TJ /TT3 1 Tf -0.004 Tc 0.014 Tw 14.22 0 Td [([)-5 (s)-5 (ee )10 (A)-3 (d)-4 (ver)-5 (s)-5 (e R)-3 (ea)-4 (ct)-6.1 (i)-5.9 (o)-4 (n)-4 (s)-5 ( \()]TJ 0 Tc 0 Tw 9.9 0 Td (6.1)Tj -0.033 Tc 0.033 Tw 1.26 0 Td (\)])Tj /TT0 1 Tf 0 Tc 0 Tw 0.73 0 Td (. )Tj EMC /P <>BDC /TT1 1 Tf 14.04 0 0 14.04 94.2488 607.2703 Tm (6 )Tj -0.004 Tc 0.002 Tw 3.846 0 Td [(ADVE)-3.7 (RS)-3.5 (E)-3.7 ( RE)-3.6 (ACT)-12.2 (I)-8.2 (O)-3.8 (NS )]TJ EMC /P <>BDC /TT0 1 Tf 0.004 Tw 12 0 0 12 94.2488 586.7503 Tm [(T)-3 (h)-4 (e )]TJ 0 Tc 0 Tw [(f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng a)4 (dve)4 (r)3 (s)-11 (e)4 ( r)3 (e)-6 (a)4 (c)4 (t)-2 (i)-2 (ons)-1 ( a)4 (r)3 (e)4 ( di)-2 (s)-1 (c)4 (us)-1 (s)-11 (e)4 (d i)-2 (n gr)3 (e)4 (a)4 (t)-2 (e)-6 (r)3 ( de)4 (t)-2 (a)4 (i)-2 (l)-2 ( i)-2 (n ot)-2 (he)4 (r)3 ( s)-1 (e)-6 (c)4 (t)-2 (i)-2 (ons)-1 ( of)3 ( t)-2 (he)4 ( l)-2 (a)4 (be)4 (l)-2 (: )]TJ EMC /Lbl <>BDC /C2_0 1 Tf 3 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(C)-3 (a)4 (r)3 (di)-2 (om)-12 (y)20 (opa)4 (t)-2 (h)-20 (y )]TJ /TT3 1 Tf 6.96 0 Td [([)-1 (s)-1 (e)-6 (e )-6 (W)13 (a)-10 (r)-1 (ni)-2 (ngs)-1 ( and P)1 (r)-1 (e)4 (c)4 (aut)-2 (i)-2 (ons)-1 ( \()3 (5.1)]TJ -0.033 Tc 0.033 Tw (\)] )Tj EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 0 Tw -8.46 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(I)13 (n)-10 (f)3 (us)-1 (i)-2 (on R)-3 (e)4 (a)4 (c)4 (t)-2 (i)-2 (ons )]TJ /TT3 1 Tf 7.77 0 Td [([)-1 (s)-1 (e)4 (e )-6 (W)13 (ar)-1 (ni)-2 (ngs)-1 ( and P)1 (r)-1 (e)-6 (c)4 (aut)-2 (i)-2 (ons)-1 ( \()13 (5.2)]TJ -0.033 Tc 0.033 Tw 14.47 0 Td (\)] )Tj EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 0 Tw -23.74 -1.73 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf -0.001 Tc 0.001 Tw 1.5 0 Td [(Em)-3 (b)]TJ -0.02 Tc 0.02 Tw 1.89 0 Td [(r)-27 (yo)]TJ 0 Tc 0 Tw 1.32 0 Td (-)Tj 0.002 Tc -0.002 Tw 0.34 0 Td [(F)-2 (e)6 (ta)6 (l T)3 (o)2 (x)-8 (ic)6 (it)-10 (y )]TJ /TT3 1 Tf 0 Tc 0 Tw 5.88 0 Td [([)-1 (s)-11 (e)4 (e )-6 (W)13 (ar)-1 (ni)-2 (ngs)-1 ( and P)1 (r)-1 (e)-6 (c)4 (aut)-2 (i)-2 (ons)-1 ( \()13 (5.3)]TJ -0.033 Tc 0.033 Tw 14.48 0 Td (\)] )Tj EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 0 Tw -25.41 -1.72 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf 1.5 0 Td [(P)-4 (ul)-2 (m)-2 (ona)4 (r)-7 (y)20 ( T)1 (ox)-10 (i)-2 (c)4 (i)-2 (t)-12 (y )]TJ /TT3 1 Tf 8.27 0 Td [([)-1 (s)-1 (e)4 (e )-6 (W)13 (ar)-1 (ni)-2 (ngs)-1 ( and P)1 (r)-1 (e)-6 (c)4 (aut)-2 (i)-2 (ons)-1 ( \()13 (5.4)]TJ -0.033 Tc 0.033 Tw 14.47 0 Td (\)] )Tj EMC /Lbl <>BDC /C2_0 1 Tf 0 Tc 0 Tw -24.24 -1.71 Td <0078>Tj /T1_0 1 Tf (\003\003)Tj EMC /LBody <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 1.5 0 Td [(E)-3 (x)-14 (acer)-1 (b)-4 (at)-6 (i)-6 (o)-4 (n)-4 ( o)-4 (f)-1 ( C)-7 (h)-4 (em)-6 (o)-4 (t)-16 (h)-3.9 (er)-1.1 (ap)-23.9 (y)]TJ 0 Tc 0 Tw 12.49 0 Td [(-)3 (i)-2 (ndu)-10 (c)4 (e)4 (d N)-8 (e)4 (ut)-2 (r)3 (ope)-6 (ni)-2 (a )]TJ /TT3 1 Tf 8.95 0 Td [([)-1 (s)-1 (e)4 (e )-6 (W)13 (ar)-1 (ni)-2 (ngs)-1 ( and P)-9 (r)-1 (e)4 (c)4 (aut)-2 (i)-2 (ons )]TJ -21.44 -1.17 Td [(\()13 (5.5)]TJ -0.023 Tc 0.023 Tw 1.58 0 Td (\)] )Tj EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw -6.08 -1.66 Td [(T)1 (he)4 ( m)-2 (os)-1 (t)-2 ( c)4 (om)-2 (m)-2 (on a)4 (dve)4 (r)-7 (s)-1 (e)4 ( r)3 (e)4 (a)-6 (c)4 (t)-2 (i)-2 (ons)-1 ( i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( r)3 (e)-6 (c)4 (e)4 (i)-2 (vi)-2 (ng)10 ( t)-2 (r)-7 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (s)-1 ( i)-2 (n t)-2 (he)4 ( a)4 (dj)-2 (uva)4 (n)]TJ 0.002 Tc -0.002 Tw (t )Tj -0.004 Tc 0.004 Tw T* [(an)-4 (d)-4 ( m)-6 (et)-6 (as)-5 (t)-6 (at)-6 (i)-6 (c b)-4 (r)-1 (e)-10 (as)-5 (t)-6 ( can)-13.9 (cer)-0.9 ( s)-5 (et)-6 (t)-6 (i)-6 (n)-14 (g)6 ( ar)-11 (e f)-11 (ev)-4 (er)-1 (,)-4 ( n)-14 (au)-14 (s)-5 (ea,)-4 ( v)-4 (o)-4 (m)-6 (i)-6 (t)-6 (i)-6 (n)-4 (g)6 (,)-4 ( i)-6 (n)-4 (f)-1 (u)-4 (s)-5 (i)-6 (o)-4 (n)-4 ( r)-0.9 (e)-10 (act)-6.1 (i)-5.9 (o)-4 (n)-4 (s)-5 (,)-4 ( d)-4 (i)-6 (ar)-1 (r)-1 (h)-4 (e)-10 (a, )]TJ 0 Tc 0 Tw T* [(i)-2 (nf)3 (e)4 (c)4 (t)-2 (i)-2 (ons)-1 (, i)-2 (nc)4 (r)3 (e)-6 (a)4 (s)-1 (e)4 (d c)4 (ou)-10 (g)10 (h, he)-6 (a)4 (da)-6 (c)4 (he)4 (, f)-7 (a)4 (t)-2 (i)-2 (g)10 (u)-10 (e)4 (, d)-20 (y)10 (s)-1 (pne)4 (a)4 (, r)3 (a)4 (s)-1 (h, n)-10 (e)4 (ut)-2 (r)3 (ope)4 (ni)-2 (a)4 (, )-10 (a)4 (ne)4 (m)-2 (i)-2 (a)4 (, a)4 (nd m)-22 (y)20 (a)4 (l)-12 (g)10 (i)-2 (a)4 (. )]TJ 0 -1.16 TD [(A)2 (dve)4 (r)3 (s)-1 (e )-6 (r)3 (e)4 (a)-6 (c)4 (t)-2 (i)-2 (ons)-1 ( r)3 (e)4 (qui)-2 (r)3 (i)-12 (ng)10 ( i)-2 (nt)-2 (e)4 (r)-7 (r)3 (upt)-2 (i)-2 (on or)3 ( di)-2 (s)-1 (c)4 (ont)-2 (i)-2 (nua)4 (t)-2 (i)-2 (on of)3 ( t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 ( t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt )]TJ 0 -1.17 TD [(i)-2 (nc)4 (l)-2 (ude)4 ( C)-3 (H)2 (F)6 (, s)-1 (i)-12 (g)10 (ni)-2 (f)3 (i)-2 (c)4 (a)4 (nt )-12 (de)4 (c)4 (l)-2 (i)-2 (ne)4 ( i)-2 (n l)-2 (e)4 (f)3 (t)-2 ( ve)4 (nt)-2 (r)3 (i)-2 (c)4 (ul)-12 (a)4 (r)-7 ( c)4 (a)4 (r)3 (di)-2 (a)-6 (c)4 ( f)3 (unc)4 (t)-2 (i)-2 (on, s)-1 (e)4 (v)-10 (e)4 (r)3 (e )-6 (i)-2 (nf)3 (us)-1 (i)-2 (on r)3 (e)4 (a)4 (c)4 (t)-2 (i)-2 (ons)-1 (, )]TJ T* [(a)4 (nd pul)-2 (m)-2 (ona)4 (r)-17 (y)20 ( t)-2 (ox)-10 (i)-2 (c)4 (i)-2 (t)-12 (y )]TJ /TT3 1 Tf 9.57 0 Td [([)-11 (s)-1 (e)4 (e)4 ( D)2 (os)-1 (age)4 ( and A)1 (d)-10 (m)2 (i)-2 (ni)-2 (s)-1 (t)-2 (r)-1 (at)-2 (i)-2 (on \()13 (2.3)-10 (\))33 (])]TJ /TT0 1 Tf 15.55 0 Td (. )Tj EMC /Span <>BDC /TT1 1 Tf -0.002 Tc 14.04 0 0 14.04 94.2488 351.7904 Tm [(6)-6.3 (.1 )]TJ EMC /Span <>BDC 0.004 Tc -0.006 Tw 3.846 0 Td [(C)8.1 (lin)13 (ic)3.5 (a)8.3 (l T)4.3 (r)12.1 (i)8.5 (al)8.5 (s E)4.3 (xp)12.9 (e)12.1 (r)3.6 (ie)3.5 (n)4.4 (c)12.1 (e )]TJ EMC /P <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 12 0 0 12 94.2488 331.3903 Tm [(B)3 (ec)-10 (au)-4 (s)-5 (e )-10 (cl)-6 (i)-6 (n)-4 (i)-6 (cal)-6 ( t)-6 (r)-1 (i)-6 (al)-6 (s)-4.9 ( ar)-11 (e co)-3.9 (n)-4 (d)-4 (u)-4 (ct)-6 (ed)-4 ( u)-4 (n)-4 (d)-14 (er)-1 ( w)-2 (i)-6 (d)-4 (el)-16 (y )6 (v)-4 (a)-10 (r)-21 (y)26 (i)-6 (n)-14 (g)-4 ( co)-4 (n)-4 (d)-4 (i)-6 (t)-6 (i)-6 (o)-4 (n)-4 (s)-5 (,)-4 ( ad)-4 (v)-14 (er)-0.9 (s)-5.1 (e r)-11 (eact)-6 (i)-6 (o)-4 (n)-4 ( r)-11 (at)-6 (es )]TJ 0 Tc 0 Tw 0 -1.16 TD [(obs)-1 (e)4 (r)3 (ve)4 (d i)-2 (n t)-2 (he)4 ( c)4 (l)-2 (i)-2 (ni)-2 (c)-6 (a)4 (l)-2 ( t)-2 (r)3 (i)-2 (a)4 (l)-2 (s)-1 ( of)3 ( a)4 ( dr)3 (u)-10 (g)10 ( c)-6 (a)4 (nno)]TJ 0.002 Tc -0.002 Tw [(t b)2 (e)6 ( d)-8 (ir)5 (e)6 (c)6 (tl)-10 (y )12 (c)6 (o)2 (mp)2 (a)6 (r)-5 (e)6 (d)2 ( to)2 ( r)5 (a)6 (te)6 (s )-9 (in)2 ( th)2 (e)6 ( c)6 (lin)2 (ic)6 (a)6 (l tr)5 (ia)5.9 (ls )]TJ 0 Tc 0 Tw 0 -1.17 TD [(of)3 ( a)4 (not)-2 (he)4 (r)3 ( dr)3 (u)-10 (g a)4 (nd m)-2 (a)-16 (y )10 (not)-2 ( r)3 (e)4 (f)3 (l)-2 (e)4 (c)4 (t)-2 ( t)-2 (he )-6 (r)3 (a)4 (t)-2 (e)4 (s)-1 ( obs)-1 (e)-6 (r)-7 (ve)4 (d i)-2 (n pr)3 (a)4 (c)4 (t)-2 (i)-2 (c)-6 (e)4 (. )]TJ EMC /P <>BDC /TT3 1 Tf 0 -1.67 TD [(A)1 (dj)-2 (uv)4 (ant)-2 ( B)1 (r)-1 (e)4 (as)-1 (t)-2 ( C)-3 (anc)4 (e)4 (r )-11 (St)-2 (udi)-2 (e)4 (s )]TJ EMC /P <>BDC /TT0 1 Tf 0 -1.66 TD [(T)1 (he)4 ( da)4 (t)-2 (a)4 ( be)4 (l)-2 (ow )-8 (r)3 (e)4 (f)3 (l)-12 (e)4 (c)4 (t)-2 ( e)4 (x)-10 (pos)-1 (ur)3 (e)4 ( t)-2 (o one)4 (-)]TJ -0.02 Tc 0.02 Tw 15.89 0 Td [(ye)-26 (a)-16 (r )]TJ 0.002 Tc -0.002 Tw 1.95 0 Td [(tr)-5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ -0.004 Tc 0.014 Tw 5.15 0 Td [(t)-6 (h)-4 (er)-1 (ap)-14 (y)16 ( ac)-10 (r)-1 (o)-4 (s)-5 (s )]TJ -0.002 Tc 0.002 Tw 5.99 0 Td [(t)-4 (wo )]TJ 0 Tc 0 Tw 1.75 0 Td [(r)3 (a)4 (ndom)-2 (i)-2 (z)-6 (e)4 (d, )]TJ -30.73 -1.17 Td [(ope)4 (n-)]TJ -0.004 Tc 0.004 Tw 2.27 0 Td [(l)-6 (ab)-4 (el )]TJ 0 Tc 0 Tw 2.19 0 Td [(s)-1 (t)-2 (udi)-2 (e)4 (s)-1 (, S)-4 (t)-2 (udi)-2 (e)4 (s)-1 ( 1 )]TJ -0.004 Tc 0.004 Tw [(an)-4 (d )]TJ 0 Tc 0 Tw 8.92 0 Td [(2 w)2 (i)-2 (t)-2 (h or)3 ( w)2 (i)-2 (t)-2 (hou)-10 (t)-2 ( t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b i)-2 (n t)-2 (he)4 ( a)4 (dj)-2 (uva)4 (nt)-2 ( t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( of )]TJ -0.004 Tc 0.004 Tw -13.38 -1.17 Td [(b)-4 (r)-1 (eas)-5 (t)-6 ( c)-10 (an)-4 (ce)-10 (r)-1 (. )]TJ EMC /P <>BDC 0 Tc 0 Tw 0 -2.16 TD [(I)13 (n S)-4 (t)-2 (ud)-20 (y)20 ( 3, a )-6 (c)4 (om)-2 (pa)4 (r)3 (i)-2 (s)-1 (on)-10 ( of )]TJ 0.002 Tc -0.002 Tw 11.36 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ -0.004 Tc 0.004 Tw 5.14 0 Td [(t)-6 (r)-1 (eat)-6 (m)-6 (en)-14 (t)-6 ( f)-1 (o)-4 (r)-1 ( t)-6 (w)-2 (o )-14 (y)16 (e)-10 (ar)-1 (s)-5 ( v)-14 (er)-0.9 (s)-5.1 (u)-4 (s)-4.9 ( o)-4 (n)-14 (e )-10 (y)16 (e)-10 (ar )-11 (w)-2 (as)-5 ( al)-6 (s)-5 (o )]TJ 0 Tc 0.01 Tw -16.5 -1.17 Td [(pe)4 (r)3 (f)3 (or)3 (m)-2 (e)4 (d. T)1 (he )]TJ -0.004 Tc 0.004 Tw 6.46 0 Td [(r)-11 (at)-6 (e o)-4 (f )-11 (as)-5 (y)16 (m)-16 (p)-4 (t)-6 (o)-4 (m)-6 (at)-6 (i)-6 (c c)-10 (ar)-0.9 (d)-4 (i)-6.1 (ac d)-23.9 (y)16 (s)-15 (f)-11 (u)-4 (n)-4 (ct)-6 (i)-6 (o)-4 (n)-4 ( w)-2 (as)-5 ( i)-6 (n)-4 (cr)-1 (e)-10 (as)-5 (ed )]TJ 0 Tc 0 Tw 22.63 0 Td [(i)-2 (n )-10 (t)-2 (he)4 ( 2-)]TJ 0.006 Tc -0.006 Tw 3.35 0 Td [(y)26 (ear )]TJ 0.002 Tc -0.002 Tw -32.44 -1.17 Td [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ 0 Tc 0 Tw 5.14 0 Td [(t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( a)4 (r)-7 (m)-2 ( \()3 (8.1%)3 ( ve)4 (r)3 (s)-1 (us)-1 ( 4.6%)3 ( i)-2 (n t)-12 (he)4 ( one)4 (-)]TJ -0.02 Tc 0.02 Tw 17.92 0 Td [(ye)-26 (a)-16 (r )]TJ 0.002 Tc -0.002 Tw 1.95 0 Td [(tr)-5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b )]TJ -0.004 Tc 0.004 Tw 5.15 0 Td [(t)-6 (r)-1 (eat)-6 (m)-6 (en)-4 (t)-6 ( ar)-1 (m)-6 (\))-1 (.)-4 ( M)-5 (o)-14 (r)-1 (e )]TJ -30.16 -1.16 Td [(p)-4 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( ex)-14 (p)-4 (er)-1 (i)-6 (en)-4 (ced)-4 ( at)-6 ( l)-6 (e)-9.9 (as)-5.1 (t)-5.9 ( o)-4 (n)-4 (e ad)-4 (v)-4 (e)-10 (r)-1 (s)-5 (e r)-11 (eact)-6 (i)-6 (o)-4 (n )-14 (o)-4 (f)-1 ( G)-2 (r)-1 (ad)-14 (e 3)-4 ( o)-4 (r)-1 ( h)-4 (i)-16 (g)6 (h)-4 (er)-1 ( i)-6 (n)-4 ( t)-6 (h)-14 (e 2)]TJ 0 Tc 0 Tw 31.37 0 Td (-)Tj -0.02 Tc 0.02 Tw 0.35 0 Td [(ye)-16 (a)-26 (r )]TJ 0.002 Tc -0.002 Tw 1.95 0 Td [(tr)5 (a)6 (s)1 (tu)2 (z)]TJ -0.004 Tc 0.004 Tw 2.67 0 Td [(u)-4 (m)-6 (ab )]TJ 0 Tc 0 Tw -36.34 -1.17 Td [(t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( a)4 (r)3 (m)-2 ( \()3 (20.4)-10 (%)3 (\))3 ( c)-6 (om)-2 (pa)4 (r)3 (e)4 (d w)2 (i)-2 (t)-2 (h t)-2 (he)4 ( one)-6 (-)]TJ -0.02 Tc 0.02 Tw 18.81 0 Td [(ye)-26 (a)-16 (r )]TJ 0.002 Tc -0.002 Tw 1.95 0 Td (tr)Tj -0.004 Tc 0.004 Tw 0.61 0 Td [(as)-5 (t)-6 (u)-4 (z)-10 (u)-4 (m)-6 (ab )]TJ -0.003 Tc 0.003 Tw 4.53 0 Td [(t)-5 (re)1 (a)1 (t)-5 (m)-5 (e)1 (n)-3 (t )-15.1 (a)1 (rm)-5 ( \(1)-3 (6)-3 (.)-3 (3)-3 (%\). )]TJ EMC /P <>BDC 0 Tc 0 Tw -25.9 -1.67 Td [(T)1 (he)4 ( s)-1 (a)4 (f)3 (e)4 (t)-22 (y)20 ( d)-10 (a)4 (t)-2 (a)4 ( f)3 (r)3 (om)-2 ( S)-4 (t)-2 (u)-10 (di)-2 (e)4 (s)-1 ( 1 a)4 (nd 2 w)2 (e)4 (r)-7 (e)4 ( obt)-2 (a)4 (i)-2 (ne)-6 (d f)3 (r)3 (om)-2 ( 3655 pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 (, of )-7 (w)2 (hom)-2 ( 2000 )]TJ -0.004 Tc 0.004 Tw [(r)-1 (ec)-10 (ei)-6 (v)-4 (ed )]TJ 0.002 Tc -0.002 Tw 0 -1.16 TD [(tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b)2 (; th)2 (e)6 ( me)6 (d)2 (ia)6 (n)2 ( tr)5 (e)6 (a)6 (tme)6 (n)2 (t d)2 (u)2 (r)5 (a)6 (tio)2 (n)2 ( w)-6 (a)6 (s)1 ( 5)2 (1 )]TJ 0 Tc 0 Tw 20.74 0 Td [(w)2 (e)4 (e)4 (ks)-1 (. T)1 (he)4 ( m)-12 (e)4 (di)-2 (a)4 (n a)-6 (ge)-6 ( w)2 (a)4 (s)-1 ( 49 )]TJ -0.004 Tc 0.004 Tw 12.71 0 Td [(y)16 (ea)-10 (r)-1 (s)-5 ( \()-1 (r)-11 (an)-14 (g)6 (e: )]TJ 0 Tc 0 Tw -33.45 -1.17 Td [(24\22680\))3 (;)-2 ( 84% )]TJ -0.004 Tc 0.004 Tw 5.44 0 Td [(o)-4 (f)-1 ( p)-4 (at)-6 (i)-6 (en)-4 (t)-6 (s )-15 (w)-2 (er)-1 (e W)-10 (h)-4 (i)-6 (t)-6 (e,)-4 ( 7)]TJ 0 Tc 0 Tw 10.08 0 Td [(% )-7 (B)7 (l)-2 (a)4 (c)4 (k, 4)-10 (%)3 ( H)2 (i)-2 (s)-1 (pa)4 (ni)-2 (c)4 (, a)4 (nd 3)-10 (% )]TJ -0.004 Tc 0.004 Tw 12.83 0 Td [(A)-2 (s)-5 (i)-6 (an)-4 (. )]TJ EMC /Artifact <>BDC 0 Tc 0 Tw -9.1 -4.2 Td (9)Tj /T1_0 1 Tf (\002 )Tj EMC /Artifact <>BDC 0 g /T1_1 1 Tf 8 0 0 8 32.2488 26.3903 Tm (Reference ID: 4363704 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 120.6970062 785.2004395 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 4692 0 obj <>>>/Resources 4513 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 4693 0 obj <> endobj 4694 0 obj <>stream /
This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
 endstream endobj 4695 0 obj <> endobj 4696 0 obj <>stream q 1 0 0 1 21.552521 16.390259 cm 0 0 612 792 re W n 1 0 0 1 -21.552521 -16.390259 cm BT /Artifact <>BDC /CS0 cs 0 scn /TT0 1 Tf 3 Tr 12 0 0 12 93.5525 55.0303 Tm ( )Tj 19.75 0 Td ( )Tj 19.25 0 Td ( )Tj /TT1 1 Tf 14.04 0 0 14.04 111.0744 723.3103 Tm ( )Tj 10.548 0 Td ( )Tj /TT0 1 Tf 12 0 0 12 289.0325 674.9503 Tm ( )Tj 12.4 0 Td ( )Tj 6.98 -1.67 Td ( )Tj -25.93 -1.16 Td ( )Tj 25.11 0 Td ( )Tj -24.4 -1.17 Td ( )Tj 27.1 -1.17 Td ( )Tj -27.18 -1.16 Td ( )Tj 19.45 -1.17 Td ( )Tj 7.92 0 Td ( )Tj -30.74 -1.17 Td ( )Tj 1.68 -1.66 Td ( )Tj 0.002 Tc -0.002 Tw 9.18 0 Td ( )Tj -0.004 Tc 0.004 Tw 9.17 0 Td ( )Tj 8.45 0 Td ( )Tj 0 Tc 0 Tw -15.83 -1.17 Td ( )Tj 14.43 -2.33 Td ( )Tj -20.29 -1.17 Td ( )Tj 22.7 0 Td ( )Tj -34.17 -1.67 Td ( )Tj 17.19 0 Td ( )Tj 18.3 0 Td ( )Tj -34.24 -1.16 Td ( )Tj 0.002 Tc -0.002 Tw 5.78 0 Td ( )Tj -0.004 Tc 0.004 Tw 16.32 0 Td ( )Tj 13 0 Td ( )Tj 0 Tc 0 Tw -26.92 -1.17 Td ( )Tj 8.87 0 Td ( )Tj 15.01 0 Td ( )Tj 1.59 -1.17 Td ( )Tj 0.002 Tc -0.002 Tw -30.37 -1.16 Td ( )Tj 0 Tc 0 Tw 30.81 0 Td ( )Tj -30.97 -1.17 Td ( )Tj /TT1 1 Tf 14.04 0 0 14.04 111.0744 377.2303 Tm ( )Tj 12.325 0 Td ( )Tj /TT0 1 Tf 12 0 0 12 538.7525 356.8303 Tm ( )Tj -27.1 -1.17 Td ( )Tj 27.33 0 Td ( )Tj -19.99 -1.16 Td ( )Tj -11.29 -1.17 Td ( )Tj 0.002 Tc -0.002 Tw 29.2 -1.67 Td ( )Tj 0 Tc 0 Tw -11.98 -2.33 Td ( )Tj 15.1 -1.17 Td ( )Tj -19.08 -1.16 Td ( )Tj -6.63 -1.17 Td ( )Tj /TT1 1 Tf 14.04 0 0 14.04 111.0744 197.1103 Tm ( )Tj 11.102 0 Td ( )Tj /TT0 1 Tf 12 0 0 12 550.8725 176.7103 Tm ( )Tj -13.88 -2.33 Td ( )Tj 12.36 0 Td ( )Tj -22.88 -1.17 Td ( )Tj 12.66 0 Td ( )Tj -0.004 Tc 0.004 Tw -22.77 -1.16 Td ( )Tj 0.002 Tc -0.002 Tw 15.72 0 Td ( )Tj 19.52 0 Td ( )Tj 0 Tc 0 Tw -10.56 -1.17 Td ( )Tj 9 0 Td ( )Tj -0.004 Tc 0.004 Tw -28.88 -1.17 Td ( )Tj 0 Tc 0 Tw 0.26 0 Td ( )Tj EMC /Span <>BDC /TT1 1 Tf -0.002 Tc 0.002 Tw 0 Tr 14.04 0 0 14.04 93.5525 723.3103 Tm [(5)-6.3 (.2 )]TJ EMC /Span <>BDC -0.004 Tc 3.846 0 Td [(I)-8.2 (n)-3.5 (f)-4.4 (u)5 (s)-8.1 (i)0.5 (o)-8.3 (n)-3.5 ( Re)-4.4 (ac)-4.5 (t)-4.3 (i)0.5 (o)-8.3 (n)5 (s )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw 12 0 0 12 93.5525 702.9103 Tm [(I)13 (n)-10 (f)3 (us)-1 (i)-2 (on r)3 (e)4 (a)-6 (c)4 (t)-2 (i)-2 (ons)-1 ( c)4 (ons)-1 (i)-2 (s)-1 (t)-2 ( of)3 ( a)4 ( s)-21 (y)30 (m)-2 (pt)-2 (om)-2 ( c)4 (om)-2 (pl)-2 (e)4 (x)-10 ( c)-6 (ha)4 (r)3 (a)4 (c)4 (t)-12 (e)4 (r)3 (i)-2 (z)-6 (e)4 (d b)-20 (y)20 ( f)3 (e)4 (v)-10 (e)4 (r)3 ( a)4 (nd)-10 ( c)4 (hi)-2 (l)-2 (l)-2 (s)-1 (, a)4 (nd on )]TJ 0 -1.16 TD [(oc)4 (c)4 (a)4 (s)-1 (i)-2 (on i)-2 (nc)4 (l)-2 (ude)4 (d n)-10 (a)4 (us)-1 (e)4 (a)-6 (, vom)-2 (i)-2 (t)-2 (i)-2 (ng)10 (, pa)4 (i)-2 (n \()3 (i)-2 (n s)-1 (om)-2 (e)-6 ( c)4 (a)4 (s)-1 (e)4 (s)-1 ( a)4 (t)-2 ( t)-2 (um)-2 (or)3 ( s)-1 (i)-2 (t)-2 (e)4 (s)-1 (\))3 (, h)-10 (e)4 (a)-6 (da)4 (c)4 (he)4 (, di)-2 (z)-6 (z)-6 (i)-2 (ne)4 (s)-1 (s)-1 (, )]TJ 0 -1.17 TD [(d)-10 (y)20 (s)-1 (pne)-6 (a)4 (, h)-20 (y)20 (pot)-2 (e)4 (ns)-1 (i)-2 (on, r)3 (a)-6 (s)-1 (h, a)4 (nd a)4 (s)-1 (t)-2 (he)4 (ni)-2 (a )]TJ /TT2 1 Tf -0.004 Tc 0.004 Tw 16.54 0 Td [([)-5 (s)-5 (e)-10 (e A)-3 (d)-4 (v)-10 (er)-5 (s)-5 (e R)-3 (ea)-4 (ct)-6 (i)-6 (o)]TJ 0 Tc 0.01 Tw 8.44 0 Td [(ns)-1 ( \()]TJ 0 Tw 1.47 0 Td (6.1)Tj -0.023 Tc 0.023 Tw 1.26 0 Td [(\)])-64 (. )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw -27.71 -1.67 Td [(I)13 (n pos)-1 (t)-2 (-)3 (m)-12 (a)4 (r)3 (ke)4 (t)-2 (i)-2 (n)-10 (g)10 ( r)3 (e)4 (po)-10 (r)3 (t)-2 (s)-1 (, s)-1 (e)4 (r)3 (i)-2 (ous)-1 ( a)4 (nd f)3 (a)4 (t)-12 (a)4 (l)-2 ( i)-2 (nf)3 (us)-1 (i)-2 (on r)3 (e)4 (a)4 (c)4 (t)-2 (i)-2 (ons)-1 ( ha)4 (v)-10 (e)4 ( be)-6 (e)4 (n r)3 (e)4 (p)-10 (or)3 (t)-2 (e)4 (d. S)-4 (e)4 (ve)4 (r)-7 (e )]TJ 0 -1.16 TD [(r)3 (e)4 (a)4 (c)4 (t)-2 (i)-2 (ons)-1 (, w)2 (hi)-2 (c)4 (h i)-2 (n)-10 (c)4 (l)-2 (ude )-6 (br)3 (onc)4 (hos)-1 (pa)4 (s)-1 (m)-2 (, a)4 (n)-10 (a)4 (ph)-20 (y)30 (l)-12 (a)-6 (x)-10 (i)-2 (s)-1 (, a)4 (ng)10 (i)-2 (oe)4 (de)4 (m)-2 (a)4 (, h)-20 (y)20 (pox)-10 (i)-2 (a)4 (, a)4 (nd s)-1 (e)4 (ve)4 (r)-7 (e )]TJ 0 -1.17 TD [(h)-10 (y)20 (pot)-2 (e)4 (ns)-1 (i)-2 (on, w)-8 (e)4 (r)3 (e)4 ( us)-1 (u)-10 (a)4 (l)-2 (l)-2 (y )10 (r)-7 (e)4 (por)3 (t)-2 (e)4 (d dur)3 (i)-2 (n)-10 (g)10 ( o)-10 (r)3 ( i)-2 (m)-2 (m)-2 (e)4 (di)-2 (a)4 (t)-2 (e)4 (l)-22 (y)20 ( f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng)10 ( t)-2 (h)-10 (e)4 ( i)-2 (ni)-2 (t)-2 (i)-2 (a)4 (l)-2 ( i)-2 (nf)3 (us)-1 (i)-2 (on. )]TJ T* [(H)2 (ow)2 (e)4 (ve)-6 (r)3 (, t)-2 (he)4 ( ons)-1 (e)4 (t)-2 ( a)4 (nd )-10 (c)-6 (l)-2 (i)-2 (ni)-2 (c)4 (a)4 (l)-2 ( c)4 (our)3 (s)-1 (e)4 ( w)-8 (e)4 (r)3 (e)4 ( v)-10 (a)4 (r)3 (i)-2 (a)-6 (bl)-2 (e)4 (, i)-2 (nc)4 (l)-2 (udi)-2 (ng)10 ( pr)3 (o)-10 (gr)3 (e)4 (s)-1 (s)-1 (i)-2 (v)-10 (e)4 ( w)2 (or)3 (s)-1 (e)4 (ni)-2 (n)-10 (g)10 (, i)-2 (ni)-2 (t)-2 (i)-2 (a)4 (l )]TJ 0.002 Tc -0.002 Tw 0 -1.16 TD [(imp)2 (r)5 (o)]TJ 0 Tc 0 Tw 2.39 0 Td [(ve)4 (m)-2 (e)4 (nt)-2 ( f)3 (ol)-2 (l)-2 (ow)2 (e)4 (d b)-10 (y )10 (c)4 (l)-2 (i)-2 (ni)-2 (c)-6 (a)4 (l)-2 ( de)4 (t)-2 (e)4 (r)3 (i)-2 (or)-7 (a)4 (t)-2 (i)-2 (on, or)3 ( de)4 (l)-2 (a)-16 (y)20 (e)4 (d pos)-1 (t)-2 (-)3 (i)-2 (nf)3 (us)-1 (i)-2 (on e)-6 (ve)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h r)3 (a)4 (pi)-2 (d )]TJ -2.39 -1.17 Td [(c)4 (l)-2 (i)-2 (ni)-2 (c)4 (a)4 (l)-2 ( de)4 (t)-2 (e)4 (r)3 (i)-2 (or)-7 (a)4 (t)-2 (i)-2 (on. F)6 (or)-7 ( f)3 (a)4 (t)-2 (a)4 (l)-2 ( e)4 (ve)4 (nt)-2 (s)-1 (, d)-10 (e)4 (a)4 (t)-2 (h oc)4 (c)-6 (ur)-7 (r)3 (e)4 (d w)2 (i)-2 (t)-2 (hi)-2 (n hour)3 (s)-1 ( t)-2 (o da)-16 (y)20 (s )-11 (f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng)10 ( a)4 ( s)-11 (e)4 (r)3 (i)-2 (ous )]TJ 0 -1.17 TD [(i)-2 (nf)3 (us)-1 (i)-2 (on r)3 (e)4 (a)4 (c)4 (t)-2 (i)-2 (on. )]TJ EMC /P <>BDC 0 -1.66 TD [(I)13 (nt)-2 (e)-6 (r)3 (r)3 (upt)-2 ( H)2 (E)1 (R)-13 (Z)11 (U)2 (M)-1 (A )]TJ 0.002 Tc -0.002 Tw 8.93 0 Td [(in)2 (f)-5 (u)2 (s)1 (io)2 (n)2 ( in)2 ( a)6 (ll p)2 (a)6 (tie)6 (n)2 (ts )]TJ -0.004 Tc 0.004 Tw 9.18 0 Td [(ex)-14 (p)-4 (e)10 (r)-1 (i)-6 (en)-4 (ci)-6 (n)-14 (g)6 ( d)-24 (y)16 (s)-5 (p)-4 (n)-4 (ea, )-14 (cl)-6 (i)-6 (n)-4 (i)-6 (ca)-10 (l)-6 (l)-16 (y)16 ( s)-4.9 (i)-6 (g)6 (n)-4 (i)-6 (f)-1 (i)-16 (can)-4 (t )]TJ 0 Tc 0 Tw -18.11 -1.17 Td [(h)-10 (y)20 (pot)-2 (e)4 (ns)-1 (i)-2 (on, a)4 (nd i)-2 (nt)-2 (e)-6 (r)3 (ve)-6 (nt)-2 (i)-2 (on of)3 ( m)-2 (e)4 (di)-2 (c)4 (a)4 (l)-2 ( t)-2 (he)4 (r)3 (a)4 (p)-20 (y )10 (a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d \()3 (w)2 (hi)-2 (c)4 (h m)-2 (a)-16 (y)10 ( i)-2 (nc)4 (l)-2 (ude)4 ( e)4 (pi)-2 (ne)4 (phr)3 (i)-2 (ne)4 (, )]TJ 0 -1.17 TD [(c)4 (or)3 (t)-2 (i)-2 (c)4 (os)-1 (t)-2 (e)4 (r)3 (oi)-2 (ds)-1 (, di)-2 (phe)4 (nh)-20 (y)10 (dr)3 (a)4 (m)-2 (i)-2 (ne)4 (, br)3 (onc)4 (hodi)-2 (l)-2 (a)4 (t)-2 (or)3 (s)-11 (, a)4 (nd ox)-20 (y)20 (ge)4 (n\))3 (. P)-4 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( s)-11 (houl)-2 (d be)4 ( e)4 (va)4 (l)-2 (ua)4 (t)-2 (e)4 (d )]TJ 0 -1.16 TD [(a)4 (nd c)4 (a)4 (r)-7 (e)4 (f)3 (ul)-2 (l)-22 (y)20 ( m)-2 (oni)-2 (t)-2 (or)3 (e)4 (d )-10 (unt)-2 (i)-2 (l)-2 ( c)4 (om)-2 (pl)-2 (e)4 (t)-2 (e)4 ( r)3 (e)4 (s)-1 (ol)-2 (ut)-2 (i)-2 (on of)3 ( s)-1 (i)-2 (g)10 (ns)-1 ( a)4 (nd s)-21 (y)20 (m)-2 (pt)-2 (om)-2 (s)-1 (. )-10 (P)-4 (e)4 (r)3 (m)-2 (a)4 (ne)4 (nt )]TJ 0 -1.17 TD [(di)-2 (s)-1 (c)4 (ont)-2 (i)-2 (nua)4 (t)-2 (i)-2 (on s)-1 (houl)-2 (d b)10 (e)4 ( s)-1 (t)-2 (r)3 (ong)10 (l)-22 (y )10 (c)4 (ons)-1 (i)-2 (de)4 (r)3 (e)4 (d i)-2 (n )-10 (a)4 (l)-2 (l)-2 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h s)-1 (e)4 (ve)4 (r)3 (e)4 ( i)-2 (n)-10 (f)3 (us)-1 (i)-2 (on r)3 (e)4 (a)4 (c)4 (t)-2 (i)-2 (ons)-1 (. )]TJ EMC /P <>BDC 0 -1.67 TD [(T)1 (he)4 (r)3 (e )-6 (a)4 (r)3 (e)4 ( no d)-10 (a)4 (t)-2 (a)4 ( r)-7 (e)-6 (g)10 (a)4 (r)3 (di)-12 (ng)10 ( t)-2 (he)4 ( m)-2 (os)-1 (t)-2 ( a)4 (ppr)3 (op)-10 (r)3 (i)-2 (a)4 (t)-2 (e )-6 (m)-2 (e)4 (t)-2 (hod of)3 ( i)-2 (de)4 (nt)-2 (i)-2 (f)3 (i)-2 (c)4 (a)4 (t)-2 (i)-2 (on of)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (ho m)-2 (a)-16 (y )]TJ -0.004 Tc 0.004 Tw 0 -1.16 TD [(s)-5 (af)-1 (el)-26 (y)16 ( b)-4 (e )]TJ 0.002 Tc -0.002 Tw [(r)-5 (e)6 (tr)5 (e)-4 (a)6 (te)6 (d)2 ( w)4 (ith )]TJ 0 Tc 0 Tw 9.6 0 Td [(t)-2 (r)-7 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b )]TJ -0.004 Tc 0.004 Tw [(p)-4 (r)-1 (o)-4 (d)-4 (u)-4 (ct)-6 (s)-5 ( af)-1 (t)-6 (er)-11 ( ex)-14 (p)-4 (er)-1 (i)-5.9 (en)-3.9 (ci)-6 (n)-4 (g )-4 (a s)-5 (ev)-14 (er)-1 (e i)-6 (n)-14 (f)-1 (u)-4 (s)-5 (i)-6 (o)-4 (n)-4 ( r)-1 (eact)-6 (i)-6 (o)-4 (n)-4 (.)-4 ( P)-8 (r)-1 (i)-6 (o)-4 (r )]TJ 0 Tc 0 Tw -9.6 -1.17 Td [(t)-2 (o r)3 (e)4 (s)-1 (um)-2 (pt)-2 (i)-2 (on of)3 ( t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b i)-2 (nf)3 (us)-1 (i)-2 (on, t)-2 (he)4 ( m)-2 (a)4 (j)-2 (or)3 (i)-2 (t)-2 (y )10 (of)3 ( p)-10 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (ho e)4 (x)-10 (pe)4 (r)3 (i)-2 (e)-6 (nc)4 (e)4 (d a)4 ( s)-1 (e)4 (v)-10 (e)4 (r)-7 (e )]TJ 0 -1.17 TD [(i)-2 (nf)3 (us)-1 (i)-2 (on r)3 (e)4 (a)4 (c)4 (t)-2 (i)-2 (on w)2 (e)-6 (r)3 (e)4 ( pr)-7 (e)4 (-)]TJ 0.002 Tc -0.002 Tw 10.79 0 Td [(me)6 (d)2 (ic)6 (a)6 (t)-10 (e)6 (d)2 ( w)4 (ith)2 ( a)6 (n)2 (tih)2 (is)1 (ta)6 (min)2 (e)6 (s)1 ( a)6 (n)2 (d)2 (/o)2 (r)5 ( c)6 (o)2 (r)5 (tic)6 (o)2 (s)0.9 (t)-10 (e)6.1 (r)-5.1 (o)2 (i)]TJ 0 Tc 0 Tw [(ds)-0.9 (. W)-6.1 (hi)-2 (l)-1.9 (e)3.9 ( s)-0.9 (om)-2 (e )]TJ 0.002 Tc -0.002 Tw -10.79 -1.16 Td [(p)2 (a)6 (tie)6 (n)2 (ts)1 ( to)2 (le)6 (r)5 (a)6 (te)6 (d )]TJ 0 Tc 0 Tw 7.1 0 Td [(t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b i)-2 (nf)3 (us)-1 (i)-2 (ons)-1 (, ot)-2 (he)4 (r)3 (s)-1 ( ha)4 (d r)3 (e)4 (c)4 (u)-10 (r)3 (r)3 (e)4 (nt)-2 ( s)-11 (e)4 (ve)4 (r)-7 (e)4 ( i)-2 (nf)3 (us)-1 (i)-2 (on r)3 (e)4 (a)4 (c)4 (t)-2 (i)-2 (ons)-1 ( de)4 (s)-1 (pi)-2 (t)-2 (e )]TJ -0.003 Tc -7.1 -1.17 Td [(p)-3 (re)]TJ 0 Tc 1.27 0 Td (-)Tj 0.002 Tc 0.33 0 Td [(me)6 (d)2 (ic)-4 (a)6 (tio)2 (n)2 (s)1 (. )]TJ EMC /Span <>BDC /TT1 1 Tf -0.002 Tc 14.04 0 0 14.04 93.5525 377.2303 Tm [(5)-6.3 (.3 )]TJ EMC /Span <>BDC -0.012 Tc 0.012 Tw 3.846 0 Td [(E)-11.7 (m)0.5 (b)-11.5 (r)-12.4 (y)-16.3 (o)]TJ 0 Tc 0 Tw 3.496 0 Td (-)Tj 0.004 Tc -0.006 Tw [(F)8.1 (e)3.6 (t)12.2 (al T)12.9 (ox)8.3 (ic)12.1 (it)3.6 (y )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw 12 0 0 12 93.5525 356.8303 Tm [(T)1 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 (s)-1 ( c)4 (a)-6 (n c)4 (a)4 (us)-1 (e)4 ( f)-7 (e)4 (t)-2 (a)4 (l)-2 ( ha)4 (r)3 (m)-2 ( w)2 (h)-10 (e)4 (n )-10 (a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d t)-2 (o a)4 ( pr)3 (e)-6 (g)10 (n)-10 (a)-6 (nt)-2 ( w)2 (om)-2 (a)4 (n. )-10 (I)13 (n pos)-1 (t )]TJ 0.002 Tc 0.008 Tw T* [(ma)6 (r)5 (k)2 (e)6 (tin)2 (g)12 ( r)5 (e)]TJ 0 Tc 0 Tw 5.07 0 Td [(por)3 (t)-2 (s)-1 (, us)-1 (e)4 ( o)-10 (f )-7 (t)-2 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b dur)3 (i)-2 (ng)10 ( pr)-7 (e)-6 (gna)4 (nc)-16 (y)20 ( r)3 (e)4 (s)-1 (ul)-2 (t)-2 (e)4 (d i)-2 (n )-10 (c)4 (a)4 (s)-1 (e)4 (s)-1 ( o)-10 (f)3 ( ol)-2 (i)-2 (g)10 (oh)-20 (y)20 (dr)-7 (a)4 (m)-2 (ni)-2 (os )]TJ -5.07 -1.16 Td [(a)4 (nd ol)-2 (i)-2 (g)10 (oh)-20 (y)20 (dr)-7 (a)4 (m)-2 (ni)-2 (os)-1 ( s)-1 (e)4 (que)4 (nc)4 (e)4 ( m)-2 (a)4 (ni)-2 (f)-7 (e)4 (s)-1 (t)-2 (i)-2 (ng a)4 (s)-1 ( pul)-2 (m)-2 (ona)4 (r)-7 (y)20 ( h)-20 (y)20 (p)-10 (opl)-2 (a)4 (s)-1 (i)-2 (a)4 (, s)-1 (ke)4 (l)-2 (e)-6 (t)-2 (a)4 (l)-2 ( a)4 (bnor)3 (m)-2 (a)4 (l)-2 (i)-2 (t)-2 (i)-2 (e)4 (s)-1 (, a)4 (nd )]TJ T* [(ne)4 (ona)4 (t)-2 (a)4 (l)-2 ( de)-6 (a)4 (t)-2 (h. )]TJ EMC /P <>BDC 0 -1.67 TD [(V)2 (e)4 (r)3 (i)-2 (f)-17 (y)20 ( t)-2 (he)4 ( pr)-7 (e)-6 (g)10 (na)4 (n)-10 (c)-16 (y)20 ( s)-1 (t)-2 (a)4 (t)-12 (us)-1 ( of)3 ( f)3 (e)4 (m)-2 (a)4 (l)-2 (e)4 (s)-1 ( o)-10 (f)3 ( r)3 (e)4 (p)-10 (r)3 (oduc)-6 (t)-2 (i)-2 (ve)4 ( pot)-2 (e)4 (nt)-2 (i)-2 (a)4 (l)-2 ( p)]TJ 0.002 Tc -0.002 Tw [(r)5 (io)2 (r)5 ( to)2 ( th)2 (e)6 ( in)2 (itia)6 (tio)2 (n)2 ( o)2 (f )]TJ 0 Tc 0 Tw 0 -1.16 TD [(H)2 (E)1 (R)-3 (Z)11 (U)2 (M)-1 (A)2 (. )-10 (A)2 (dvi)-2 (s)-1 (e)4 ( pr)3 (e)-6 (g)10 (na)4 (nt)-2 ( w)2 (om)-12 (e)4 (n a)4 (nd f)-7 (e)4 (m)-2 (a)4 (l)-2 (e)-6 (s)-1 ( of)3 ( r)3 (e)4 (pr)3 (odu)-10 (c)4 (t)-2 (i)-2 (ve)4 ( pot)-2 (e)4 (nt)-2 (i)-2 (a)4 (l)-2 ( t)-2 (ha)4 (t)-2 ( e)4 (x)-10 (pos)-1 (ur)3 (e)4 ( t)-2 (o )]TJ 0 -1.17 TD [(H)2 (E)1 (R)-3 (Z)11 (U)2 (M)-1 (A)2 ( du)-10 (r)3 (i)-2 (n)-10 (g)10 ( pr)3 (e)-6 (gna)4 (nc)-16 (y)20 ( or)3 ( w)2 (i)-2 (t)-2 (hi)-2 (n 7 m)-2 (ont)-2 (hs)-1 ( pr)3 (i)-2 (or)3 ( t)-2 (o c)4 (onc)4 (e)4 (pt)-2 (i)-2 (on c)-6 (a)4 (n r)-7 (e)4 (s)-1 (ul)-2 (t)-2 ( i)-2 (n f)3 (e)4 (t)-2 (a)4 (l)-2 ( ha)4 (r)3 (m)-2 (. )]TJ -0.004 Tc 0.004 Tw T* [(A)-2 (d)-4 (v)-4 (i)-6 (s)-5 (e f)-1 (em)-6 (al)-6 (es)-5 ( o)-14 (f)-1 ( r)-1 (ep)-14 (r)-1 (o)-4 (d)-14 (u)-4 (ct)-5.9 (i)-6.1 (v)-3.9 (e p)-4 (o)-4 (t)-6 (en)-4 (t)-6 (i)-6 (al)-6 ( t)-6 (o)-4 ( u)-4 (s)-5 (e ef)-1 (f)-11 (ect)]TJ 0 Tc 0 Tw 21.46 0 Td [(i)-2 (ve)4 ( c)4 (ont)-2 (r)-7 (a)4 (c)4 (e)4 (pt)-2 (i)-2 (on dur)3 (i)-12 (ng)10 ( t)-2 (r)3 (e)-6 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( a)4 (nd f)3 (o)-10 (r )]TJ -21.46 -1.16 Td [(7 m)-2 (ont)-2 (hs)-1 ( f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng)10 ( t)-2 (he)4 ( l)-2 (a)4 (s)-1 (t)-2 ( dos)-1 (e)4 ( of)3 ( H)2 (E)1 (R)-13 (Z)11 (U)2 (M)-1 (A )]TJ /TT2 1 Tf 19.54 0 Td [([)-11 (s)-1 (e)4 (e)4 ( U)2 (s)-1 (e)4 ( i)-2 (n Spe)-6 (c)4 (i)-2 (f)-2 (i)-2 (c)4 ( P)1 (opul)-2 (at)-2 (i)-2 (ons)-1 ( \()13 (8.1, 8.3)-10 (\))13 ( and )]TJ -19.54 -1.17 Td [(C)-3 (l)-2 (i)-2 (ni)-2 (c)4 (al)-2 ( P)1 (har)-1 (m)2 (ac)4 (ol)-2 (ogy)4 ( \()3 (12.3\))]TJ 0.041 Tc -0.041 Tw 11.99 0 Td (]. )Tj EMC /Span <>BDC /TT1 1 Tf -0.002 Tc 0 Tw 14.04 0 0 14.04 93.5525 197.1103 Tm [(5)-6.3 (.4 )]TJ EMC /Span <>BDC 0.004 Tc -0.006 Tw 3.846 0 Td [(P)8.2 (u)4.4 (lm)16.5 (on)4.4 (ar)12.1 (y T)4.3 (o)8.3 (xi)8.5 (c)3.6 (it)12.2 (y )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw 12 0 0 12 93.5525 176.7103 Tm [(T)1 (r)3 (a)4 (s)-1 (t)-2 (uz)-6 (um)-2 (a)4 (b pr)3 (oduc)4 (t)-2 ( us)-1 (e)-6 ( c)4 (a)4 (n r)3 (e)4 (s)-1 (ul)-2 (t)-2 ( i)-2 (n s)-1 (e)4 (r)3 (i)-2 (ous)-1 ( a)4 (nd )-10 (f)3 (a)4 (t)-2 (a)4 (l)-2 ( pul)-2 (m)-2 (ona)4 (r)-17 (y)20 ( t)-2 (ox)-10 (i)-2 (c)4 (i)-2 (t)-12 (y)30 (. )-10 (P)-4 (ul)-2 (m)-2 (ona)4 (r)-7 (y)20 ( t)-2 (ox)-10 (i)-2 (c)4 (i)-2 (t)-12 (y )]TJ 0 -1.16 TD [(i)-2 (nc)4 (l)-2 (ude)4 (s)-1 ( d)-10 (y)20 (s)-1 (pn)-10 (e)4 (a)4 (, i)-2 (nt)-2 (e)4 (r)3 (s)-1 (t)-2 (i)-12 (t)-2 (i)-2 (a)4 (l)-2 ( pne)4 (um)-2 (oni)-2 (t)-2 (i)-2 (s)-1 (, pul)-2 (m)-2 (on)10 (a)4 (r)-17 (y)20 ( i)-2 (nf)3 (i)-2 (l)-2 (t)-2 (r)3 (a)4 (t)-2 (e)4 (s)-1 (, pl)-2 (e)4 (ur)-7 (a)4 (l)-2 ( e)4 (f)-7 (f)-7 (us)-1 (i)-2 (ons)-1 (, )]TJ 0 -1.17 TD [(non-)3 (c)4 (a)4 (r)3 (di)-2 (o)-10 (ge)4 (ni)-2 (c)4 ( pul)-2 (m)-2 (ona)4 (r)-17 (y)20 ( e)4 (de)4 (m)-12 (a)4 (, pul)-2 (m)-2 (ona)4 (r)-17 (y)20 ( i)-2 (n)-10 (s)-1 (uf)3 (f)3 (i)-2 (c)4 (i)-2 (e)4 (nc)-16 (y )10 (a)4 (nd h)-20 (y)20 (pox)-10 (i)-2 (a)4 (, a)4 (c)4 (ut)-2 (e)4 ( r)-7 (e)4 (s)-1 (pi)-2 (r)3 (a)4 (t)-2 (or)-17 (y )]TJ T* [(di)-2 (s)-1 (t)-2 (r)3 (e)4 (s)-1 (s)-1 ( s)-11 (y)20 (ndr)3 (om)-2 (e)4 (, )-10 (a)4 (nd p)-10 (ul)-2 (m)-2 (ona)4 (r)-7 (y )10 (f)3 (i)-2 (br)3 (os)-1 (i)-2 (s)-1 (. 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This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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76.919 0.72 re f 376.68 313.2 0.72 0.72 re f 377.4 313.2 81.121 0.72 re f 458.52 313.2 0.72 0.72 re f 459.24 313.2 80.04 0.72 re f 539.28 313.2 0.72 0.72 re f 72 281.88 0.72 31.32 re f 72 281.16 0.72 0.72 re f 72 281.16 0.72 0.72 re f 72.72 281.16 71.76 0.72 re f 144.48 281.88 0.72 31.32 re f 144.48 281.16 0.72 0.72 re f 145.2 281.16 76.2 0.72 re f 221.4 281.88 0.72 31.32 re f 221.4 281.16 0.72 0.72 re f 222.12 281.16 76.92 0.72 re f 299.04 281.88 0.72 31.32 re f 299.04 281.16 0.72 0.72 re f 299.76 281.16 76.919 0.72 re f 376.68 281.88 0.72 31.32 re f 376.68 281.16 0.72 0.72 re f 377.4 281.16 81.121 0.72 re f 458.52 281.88 0.72 31.32 re f 458.52 281.16 0.72 0.72 re f 459.24 281.16 80.04 0.72 re f 539.28 281.88 0.72 31.32 re f 539.28 281.16 0.72 0.72 re f 539.28 281.16 0.72 0.72 re f q 1 0 0 1 -22.093231 -16.96875 cm BT /TT0 1 Tf 3 Tr 9.96 0 0 9.96 96.9732 288.7687 Tm ( )Tj 5.602 0 Td [( )-1449 ( )]TJ 0.002 Tc 0.001 Tw -0.529 -1.157 Td ( )Tj 0 Tc 0 Tw 10.807 0 Td ( )Tj -15.844 -1.156 Td ( )Tj 34.422 0 Td ( )Tj -0.001 Tc 0.004 Tw 5.048 0 Td ( )Tj 6.048 0 Td ( )Tj 0.001 Tw -40.939 -1.157 Td ( )Tj 0 Tc 0 Tw 4.917 0 Td ( )Tj -9.531 -1.144 Td ( )Tj -0.001 Tc 0.004 Tw 7.988 0 Td ( )Tj 0.006 Tc -0.003 Tw 24.457 0 Td ( )Tj 0 Tc 0 Tw 6.06 0 Td ( )Tj -38.469 -1.157 Td ( )Tj /C2_1 1 Tf 0.006 Tc 2.578 0 Td [<0003>-4707.8 <0003>-4852.3 <0003>]TJ 19.554 0 Td [<0003>-4816.3 <0003>-3840.2 <0003>-3695.9 <0003>]TJ /TT0 1 Tf 0 Tc 14.205 0 Td ( )Tj 0.002 Tc 0.001 Tw 6.013 0 Td ( )Tj /C2_1 1 Tf 0 Tw -37.772 -1.157 Td [<0003>-4687.8 <0003>-3833.2 <0003>-1447.1 <0003>-4519.9 <0003>-1663.6 <0003>]TJ /TT0 1 Tf 0 Tc 25.77 0 Td ( )Tj 12 0 0 12 94.0932 200.2087 Tm ( )Tj ET Q EMC 1 0 0 1 -22.093231 -16.96875 cm BT /Span <>BDC /TT0 1 Tf 12 0 0 12 94.0932 725.5688 Tm [(f)3 (r)3 (om)-2 ( ba)4 (s)-1 (e)4 (l)-2 (i)-2 (ne)4 ( t)-2 (o e)4 (nd o)-10 (f )-7 (A)2 (C)-3 (\))3 (. F)6 (ol)-2 (l)-2 (o)]TJ 0.002 Tc -0.002 Tw [(w)4 (in)2 (g)12 ( in)2 (itia)6 (tio)2 (n)-8 ( o)2 (f)5 ( tr)5 (a)6 (s)1 (tu)2 (z)-4 (u)2 (ma)6 (b)2 ( th)2 (e)6 (r)5 (a)6 (p)-18 (y)22 (, )-8 (th)2 (e)6 ( in)2 (c)5.9 (id)2 (e)5.9 (n)2.1 (c)6 (e)5.9 ( o)-8 (f )]TJ -0.004 Tc 0.004 Tw 0 -1.16 TD [(n)-4 (ew)]TJ 0 Tc 0 Tw 1.66 0 Td [(-)3 (ons)-1 (e)4 (t)-2 ( dos)-1 (e)-6 (-)]TJ 0.002 Tc -0.002 Tw 4.86 0 Td [(limitin)2 (g)12 ( m)-10 (y)22 (o)2 (c)-4 (a)6 (r)5 (d)2 (ia)6 (l d)-18 (y)22 (s)1 (f)5 (u)2 (n)2 (c)6 (tio)2 (n )-8 (w)4 (a)6 (s)1 ( h)2 (ig)12 (h)-8 (e)6 (r)5 ( a)6 (mo)2 (n)-8 (g)11.9 ( p)-7.9 (a)5.9 (tie)5.9 (n)-8 (ts)0.9 ( r)5 (e)6 (c)6 (e)6 (iv)2 (in)-8 (g )]TJ -0.004 Tc 0.004 Tw -6.52 -1.17 Td [(t)-6 (r)-1 (as)-5 (t)-6 (u)-4 (z)-10 (u)-4 (m)-6 (ab)-4 ( an)-4 (d)-4 ( p)-4 (acl)-6 (i)-6 (t)-6 (ax)-13.9 (el)-6.1 ( as)-4.9 ( co)-4 (m)-6 (p)-4 (ar)-11 (ed)-4 ( t)-6 (o)-4 ( t)-6 (h)-4 (o)-4 (s)-5 (e r)-11 (ecei)-6 (v)-4 (i)-6 (n)-14 (g)6 ( p)-4 (a)-10 (cl)-6 (i)-6 (t)-6 (ax)-14 (el)-6 ( al)-6 (o)-4 (n)-4 (e i)-6 (n)-3.9 ( S)-8 (t)-5.9 (u)-4 (d)-4 (i)-6 (es)-5 ( 1)-4 ( an)-4 (d)-4 ( 2 )]TJ 0 -1.17 TD [(\()-1 (s)-5 (ee T)-3 (ab)-4 (l)-16 (e 4)]TJ 0 Tc 0 Tw 4.88 0 Td (, )Tj -0.01 Tc 0.01 Tw [(F)-4 (i)-22 (gu)-10 (r)-17 (e )]TJ 0 Tc 0 Tw 3.36 0 Td [(1\))3 (. T)-9 (he)4 ( pe)4 (r)3 (-)]TJ -0.004 Tc 0.004 Tw 4.74 0 Td [(p)-14 (at)-6 (i)-6 (en)-4 (t)-6 ( i)-6 (n)-4 (ci)-6 (d)-4 (en)-4 (c)-10 (e )-10 (o)-4 (f)-1 ( n)-4 (ew)]TJ 0 Tc 0 Tw 9.81 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.33 0 Td [(o)-4 (n)-4 (s)-15 (et)-6 ( car)-1 (d)-4 (i)-16 (ac d)-24 (y)16 (s)-15 (f)-1 (u)-4 (n)-4 (ct)-6 (i)-6 (o)-3.9 (n)-4.1 (,)-3.9 ( as)-5 ( m)-6 (eas)-5 (u)-4 (r)-11 (ed )]TJ 0.01 Tc -0.01 Tw -23.12 -1.16 Td (by )Tj -0.011 Tc 0.011 Tw 1.25 0 Td [(LV)-9 (E)-20 (F)-5 (, )]TJ -0.004 Tc 0.004 Tw 2.99 0 Td [(r)-11 (em)-6 (ai)-6 (n)-4 (ed)-4 ( s)-5 (i)-6 (m)-6 (i)-6 (l)-6 (ar)-1 ( w)-2 (h)-4 (en )-14 (co)-3.9 (m)-6.1 (p)-4 (ar)-10.9 (ed)-4 ( t)-6 (o)-4 ( t)-6 (h)-4 (e )-10 (an)-4 (al)-26 (y)26 (s)-5 (i)-6 (s)-5 ( p)-14 (er)-1 (f)-1 (o)-14 (r)-1 (m)-6 (ed)-4 ( at)-6 ( a )-10 (m)-6 (ed)-4 (i)-6 (an)-4 ( f)-1 (o)-4 (l)-6 (l)-6 (o)-3.9 (w)]TJ 0 Tc 0 Tw 31.47 0 Td [(-)3 (up of )]TJ EMC /Span <>BDC -35.71 -1.17 Td (2.0 )Tj EMC /Span <>BDC -0.004 Tc 0.004 Tw 1.51 0 Td [(y)16 (e)-10 (ar)-1 (s)-5 ( i)-6 (n)-4 ( t)-6 (h)-4 (e A)-2 (C)]TJ 0 Tc 0 Tw 6.23 0 Td [(-)3 (T)-9 (H)2 ( a)-6 (r)3 (m)-2 (. T)1 (hi)-2 (s)-1 ( a)4 (na)4 (l)-12 (y)20 (s)-1 (i)-2 (s)-1 ( a)4 (l)-2 (s)-1 (o s)-1 (h)-10 (ow)2 (e)4 (d e)4 (vi)-2 (de)4 (n)-10 (c)4 (e)4 ( of )-7 (r)3 (e)4 (ve)-6 (r)3 (s)-1 (i)-2 (bi)-2 (l)-2 (i)-2 (t)-12 (y)30 ( of )]TJ -0.004 Tc 0.004 Tw 25.68 0 Td [(l)-16 (ef)-1 (t )]TJ 0 Tc 0 Tw -33.42 -1.17 Td [(ve)4 (nt)-2 (r)3 (i)-2 (c)4 (ul)-2 (a)4 (r)3 ( d)-20 (y)20 (s)-1 (f)3 (un)-10 (c)4 (t)-2 (i)-2 (on, w)2 (i)-2 (t)-2 (h 64.5%)3 ( of)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)-8 (ho e)4 (x)-10 (pe)4 (r)3 (i)-2 (e)4 (nc)4 (e)4 (d s)-21 (y)20 (m)-2 (pt)-2 (om)-2 (a)4 (t)-2 (i)-2 (c)4 ( C)-3 (H)2 (F)6 ( i)-2 (n t)-2 (he)4 ( A)2 (C)-3 (\255)]TJ 0.002 Tc -0.002 Tw 0 -1.16 TD [(T)3 (H)4 ( g)2 (r)5 (o)2 (u)2 (p)2 ( b)2 (e)6 (in)-8 (g)12 ( a)6 (s)-19 (y)22 (mp)2 (to)-8 (ma)6 (tic)6 ( a)6 (t la)6 (te)6 (s)1 (t f)5 (o)2 (llo)2 (w)]TJ 0 Tc 0 Tw 18.44 0 Td [(-)3 (up,)-10 ( a)4 (nd 90.3%)3 ( ha)4 (vi)-2 (n)-10 (g)10 ( f)3 (ul)-2 (l)-2 ( or)-7 ( pa)4 (r)3 (t)-2 (i)-2 (a)4 (l )-12 (L)11 (V)2 (E)1 (F )]TJ -0.004 Tc -18.44 -1.17 Td [(r)-1 (eco)-4 (v)-4 (e)-10 (r)-21 (y)16 (. )]TJ EMC /P <>BDC /TT1 1 Tf 0 Tc 0 -2.17 TD [(T)-3 (ab)-4 (l)-2 (e )4 (4)]TJ EMC /StyleSpan <>BDC 8.04 0 0 8.04 132.4932 591.5287 Tm (a)Tj EMC /P <>BDC 12 0 0 12 136.5732 587.5688 Tm (:)Tj /T1_0 1 Tf (\003 )Tj /TT1 1 Tf -0.011 Tc 0.011 Tw 2.46 0 Td [(Pe)-17 (r)]TJ 0 Tc 0 Tw 1.49 0 Td (-)Tj -0.004 Tc 0.004 Tw 0.33 0 Td [(p)-8 (a)-4 (t)-1 (i)-6 (en)-8 (t)-1 ( I)-5 (n)-8 (ci)-6 (d)-8 (en)-8 (ce o)-14 (f)-11 ( N)-2 (ew)-11.9 ( O)-6.1 (n)2.1 (s)-5.1 (et)-0.9 ( My)-4 (o)-4 (ca)-4 (rd)-8 (i)-6 (a)-14 (l)-6 ( D)-2 (y)-4 (s)-5 (f)-11 (u)2 (n)-8 (ct)-1 (i)-6 (o)-4 (n)-8 ( \()-1 (b)-8 (y)-4 ( L)-7 (V)-2 (E)3 (F)7 (\) )]TJ 0 Tc 0 Tw -1.82 -1.17 Td [(S)-4 (t)3 (u)-4 (d)-4 (i)-2 (e)4 (s)-1 ( 1, 2, )]TJ 0.004 Tc -0.004 Tw [(a)4 (nd 4 )]TJ EMC /TH <>BDC -0.005 Tc 0.005 Tw 11.04 0 0 11.04 251.4132 550.9687 Tm [(L)-1 (VE)-1.1 (F)-13.6 ( < 5)-5 (0)-5 (% )]TJ 0.002 Tc -0.013 Tw -5.055 -1.152 Td [(a)2 (n)3.7 (d )-7.4 (A)6.6 (b)3.6 (so)1.9 (l)-2.6 (u)14.6 (t)-2 (e )-11.1 (D)6.6 (ec)11.2 (rea)12.9 (se f)-2 (r)11.2 (o)2.1 (m)-2 ( B)-4.9 (a)2 (s)10.5 (el)8.3 (i)-2.6 (n)3.6 (e )]TJ EMC /TH <>BDC -0.002 Tw 20.424 0.576 Td [(A)6.6 (b)3.7 (so)2 (l)-2.7 (u)3.7 (t)8.9 (e L)5.9 (V)6.6 (E)6 (F)-6.6 ( D)6.6 (e)11.2 (crea)12.8 (se )]TJ EMC /TD <>BDC -0.004 Tc 0 Tw -20.858 -2.337 Td [(LV)0.6 (EF )]TJ 0 Tc -0.087 -1.413 Td [(<)4.8 ( 50% )]TJ EMC /TD <>BDC /C2_0 1 Tf 7.011 1.413 Td [<0095>-5.3 <0003001400130008>]TJ /T1_0 1 Tf ( )Tj /TT1 1 Tf 0.002 Tc -0.435 -1.413 Td [(d)3.7 (ecrea)12.9 (se )]TJ EMC /TD <>BDC /C2_0 1 Tf 0 Tc 7.467 1.413 Td [<0095>-5.3 <0003001400190008>]TJ /T1_0 1 Tf ( )Tj /TT1 1 Tf 0.002 Tc -0.435 -1.413 Td [(d)3.7 (ecrea)12.9 (se )]TJ EMC /TD <>BDC /C2_0 1 Tf 0 Tc 6.326 1.293 Td [<001F>4.8 <0003001500130008>10.9 <000300440051>1.6 <0047>1.7 <00030095>]TJ /T1_0 1 Tf ( )Tj /TT1 1 Tf 1.739 -1.163 Td (10% )Tj EMC /TD <>BDC /C2_0 1 Tf 6.946 0.576 Td [<0095>-5.3 <0003001500130008>]TJ /T1_0 1 Tf ( )Tj EMC /TD <>BDC /TT1 1 Tf -0.002 Tc 0.002 Tw -36.771 -2.467 Td [(St)-6 (udi)-6.6 (e)7.2 (s )]TJ 0 Tc -0.011 Tw 3.359 0 Td [(1 & )-15 (2)]TJ -0.004 Tc 0.013 Tw 6.96 0 0 6.96 162.6132 487.7287 Tm [(b,)-12.6 ( c )]TJ EMC /TD <>BDC /C2_1 1 Tf -0.005 Tc 0 Tw 11.04 0 0 11.04 110.1732 464.5688 Tm [<00240026>-1 <013A>-5 <0037>-13.6 <002B0003>]TJ /TT0 1 Tf 0 Tc -0.26 -1.163 Td [(\()-4 (n =)-1.2 ( 18)10.9 (56\) )]TJ EMC /TD <>BDC 7.597 1.163 Td (23.1% )Tj 0.206 -1.163 Td [(\()-4 (428\) )]TJ EMC /TD <>BDC 6.793 1.163 Td (18.5% )Tj 0.206 -1.163 Td [(\()-4 (344\) )]TJ EMC /TD <>BDC 6.826 1.163 Td (11.2% )Tj 0.206 -1.163 Td [(\()-4 (208\) )]TJ EMC /TD <>BDC 7.022 1.163 Td (37.9% )Tj 0.206 -1.163 Td [(\()-4 (703\) )]TJ EMC /TD <>BDC 7.391 1.163 Td (8.9% )Tj -0.044 -1.163 Td [(\()-4 (166\) )]TJ EMC /TD <>BDC /C2_1 1 Tf -0.005 Tc -35.79 -1.739 Td [<00240026>-1 <013A>-5 <00370003>]TJ /TT0 1 Tf 0 Tc -0.62 -1.163 Td [(\()-4 (n =)-1.2 ( 11)10.9 (70\) )]TJ EMC /TD <>BDC 7.597 1.163 Td (11.7% )Tj 0.206 -1.163 Td [(\()-4 (137\) )]TJ EMC /TD <>BDC 7.043 1.163 Td (7.0% )Tj 0.206 -1.163 Td [(\()-4 (82\) )]TJ EMC /TD <>BDC 6.826 1.163 Td (3.0% )Tj 0.206 -1.163 Td [(\()-4 (35\) )]TJ EMC /TD <>BDC 6.772 1.163 Td (22.1% )Tj 0.206 -1.163 Td [(\()-4 (259\) )]TJ EMC /TD <>BDC 7.391 1.163 Td (3.4% )Tj 0.206 -1.163 Td [(\()-4 (40\) )]TJ EMC /TD <>BDC /TT1 1 Tf -0.002 Tc 0.002 Tw -37.333 -1.761 Td [(St)-6 (udy )]TJ 0 Tc 0 Tw 2.75 0 Td (4)Tj 6.96 0 0 6.96 135.7332 404.2088 Tm (d )Tj EMC /TD <>BDC /TT0 1 Tf -0.004 Tc 11.04 0 0 11.04 119.6532 381.0487 Tm [(T)-12.6 (CH )]TJ 0 Tc -1.12 -1.163 Td [(\()-4 (n =)-1.2 ( 10)10.9 (56\) )]TJ EMC /TD <>BDC 7.847 1.163 Td (8.5% )Tj 0.206 -1.163 Td [(\()-4 (90\) )]TJ EMC /TD <>BDC 6.793 1.163 Td (5.9% )Tj 0.206 -1.163 Td [(\()-4 (62\) )]TJ EMC /TD <>BDC 6.826 1.163 Td (3.3% )Tj 0.206 -1.163 Td [(\()-4 (35\) )]TJ EMC /TD <>BDC 6.772 1.163 Td (34.5% )Tj 0.206 -1.163 Td [(\()-4 (364\) )]TJ EMC /TD <>BDC 7.391 1.163 Td (6.3% )Tj 0.206 -1.163 Td [(\()-4 (67\) )]TJ EMC /TD <>BDC /C2_1 1 Tf -0.005 Tc -36.398 -1.739 Td [<00240026>-1 <013A>-5 <0037>-13.6 <002B0003>]TJ /TT0 1 Tf 0 Tc -0.26 -1.163 Td [(\()-4 (n =)-1.2 ( 10)10.9 (68\) )]TJ EMC /TD <>BDC 7.978 1.163 Td (17% )Tj -0.174 -1.163 Td [(\()-4 (182\) )]TJ EMC /TD <>BDC 6.793 1.163 Td (13.3% )Tj 0.206 -1.163 Td [(\()-4 (142\) )]TJ EMC /TD <>BDC 7.076 1.163 Td (9.8% )Tj -0.044 -1.163 Td [(\()-4 (105\) )]TJ EMC /TD <>BDC 7.022 1.163 Td (44.3% )Tj 0.206 -1.163 Td [(\()-4 (473\) )]TJ EMC /TD <>BDC 7.141 1.163 Td (13.2% )Tj 0.206 -1.163 Td [(\()-4 (141\) )]TJ EMC /TD <>BDC /C2_1 1 Tf -0.005 Tc -35.791 -1.739 Td [<00240026>-1 <013A>-5 <00370003>]TJ /TT0 1 Tf 0 Tc -0.62 -1.163 Td [(\()-4 (n =)-1.2 ( 10)10.9 (50\) )]TJ EMC /TD <>BDC 7.847 1.163 Td (9.5% )Tj -0.044 -1.163 Td [(\()-4 (100\) )]TJ EMC /TD <>BDC 7.043 1.163 Td (6.6% )Tj 0.206 -1.163 Td [(\()-4 (69\) )]TJ EMC /TD <>BDC 6.826 1.163 Td (3.3% )Tj 0.206 -1.163 Td [(\()-4 (35\) )]TJ EMC /TD <>BDC 7.141 1.163 Td (34% )Tj -0.163 -1.163 Td [(\()-4 (357\) )]TJ EMC /TD <>BDC 7.391 1.163 Td (5.5% )Tj 0.206 -1.163 Td [(\()-4 (58\) )]TJ EMC /StyleSpan <>BDC 6.48 0 0 6.48 94.0932 292.2487 Tm (a )Tj EMC /P <>BDC -0.002 Tc 0.005 Tw 9.96 0 0 9.96 99.4931 288.7687 Tm [(Fo)-8 (r)-6.4 ( St)-1.1 (u)4 (d)-8 (i)-1.1 (e)-3.8 (s)1.5 ( 1 )]TJ -0.006 Tc 0.006 Tw 5.602 0 Td [(a)-7.8 (nd )]TJ 0.002 Tc 0.001 Tw 1.699 0 Td [(2)-4 (,)-1 ( ev)8 (en)8 (t)-9.1 (s)5.4 ( ar)-2.3 (e co)-4 (u)8 (n)8 (t)2.9 (ed)-4.1 ( f)9.7 (r)-2.3 (o)-16.1 (m)21 ( t)-9.1 (h)8 (e b)-4 (eg)8 (i)-9.1 (n)-4.1 (n)8.1 (i)2.9 (n)-4.1 (g)-4 ( o)-4 (f)9.7 ( t)2.9 (r)-2.4 (as)5.5 (t)2.9 (u)8 (z)-11.8 (u)-4.1 (m)9 (ab)-4 ( t)2.9 (r)-2.3 (eat)-9.1 (m)20.9 (e)-11.8 (n)8 (t)2.9 (.)-1 ( F)3.8 (o)-4.1 (r)-2.3 ( S)3.8 (t)2.9 (u)8 (d)-16.1 (y)20.1 ( 4)-4.1 (,)-1 ( ev)8.1 (e)-11.9 (n)8 (t)3 (s)5.4 ( ar)-2.3 (e )]TJ /T1_0 1 Tf (\002)Tj /TT0 1 Tf -7.843 -1.157 Td [(co)-4 (u)8 (n)8 (t)2.9 (ed)-4 ( f)9.7 (r)-2.3 (o)-16.1 (m )8.9 (t)2.9 (h)8 (e d)-4 (at)2.9 (e o)-4 (f)9.7 ( r)-2.4 (an)8 (d)-16 (o)-4 (m)8.9 (i)2.9 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This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda
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