GPR161

Functionⁱ

Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).By similarity

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: UniProtKB

Complete GO annotation...

GO - Biological processⁱ

G-protein coupled receptor signaling pathway Source: UniProtKB
multicellular organism development Source: UniProtKB-KW
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: UniProtKB
positive regulation of cAMP biosynthetic process Source: UniProtKB

Complete GO annotation...

Keywordsⁱ

Molecular function	Developmental protein, G-protein coupled receptor, Receptor, Transducer

Molecular function

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5610787. Hedgehog 'off' state. R-HSA-5632684. Hedgehog 'on' state.

Reactomeⁱ

R-HSA-5610787. Hedgehog 'off' state.
R-HSA-5632684. Hedgehog 'on' state.

Protein family/group databases

TCDBⁱ

9.A.14.1.11. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: G-protein coupled receptor 161 Alternative name(s): G-protein coupled receptor RE2
Gene namesⁱ	Name:GPR161
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23694. GPR161.

HGNCⁱ

HGNC:23694. GPR161.

Subcellular locationⁱ

Cell projection › cilium membrane By similarity; Multi-pass membrane protein By similarity
Cell membrane By similarity; Multi-pass membrane protein By similarity

Note:

Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity).By similarity

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 30	ExtracellularSequence analysisAdd BLAST	30
Transmembraneⁱ	31 – 51	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	52 – 64	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	65 – 85	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	86 – 101	ExtracellularSequence analysisAdd BLAST	16
Transmembraneⁱ	102 – 123	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	124 – 143	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	144 – 164	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	165 – 190	ExtracellularSequence analysisAdd BLAST	26
Transmembraneⁱ	191 – 211	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	212 – 269	CytoplasmicSequence analysisAdd BLAST	58
Transmembraneⁱ	270 – 290	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	291 – 306	ExtracellularSequence analysisAdd BLAST	16
Transmembraneⁱ	307 – 327	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	328 – 529	CytoplasmicSequence analysisAdd BLAST	202

GO - Cellular componentⁱ

ciliary membrane Source: Reactome
cilium Source: UniProtKB
endocytic vesicle membrane Source: Reactome
integral component of membrane Source: UniProtKB-KW
recycling endosome Source: UniProtKB

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cilium, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23432.
MalaCards human disease database More...MalaCardsⁱ	GPR161.
Open Targets More...OpenTargetsⁱ	ENSG00000143147.
PharmGKBⁱ	PA134931474.

Polymorphism and mutation databases

BioMutaⁱ	GPR161.
DMDMⁱ	48428085.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069646	1 – 529	G-protein coupled receptor 161Add BLAST		529

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	4	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	15	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	100 ↔ 178	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8N6U8.
PeptideAtlas More...PeptideAtlasⁱ	Q8N6U8.
PRIDEⁱ	Q8N6U8.
TopDownProteomicsⁱ	Q8N6U8-1. [Q8N6U8-1]

PTM databases

iPTMnetⁱ	Q8N6U8.
PhosphoSitePlusⁱ	Q8N6U8.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000143147.
CleanExⁱ	HS_GPR161.
ExpressionAtlasⁱ	Q8N6U8. baseline and differential.
Genevisibleⁱ	Q8N6U8. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA015576. HPA072047.

HPAⁱ

HPA015576.
HPA072047.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	117000. 16 interactors.
IntActⁱ	Q8N6U8. 1 interactor.
STRINGⁱ	9606.ENSP00000271357.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N6U8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656. Eukaryota. ENOG410XRW9. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137933.
HOGENOMⁱ	HOG000112777.
HOVERGENⁱ	HBG051789.
InParanoidⁱ	Q8N6U8.
KEGG Orthology (KO) More...KOⁱ	K08439.
OMAⁱ	IWCALLP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G56.
PhylomeDBⁱ	Q8N6U8.
TreeFamⁱ	TF331895.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequences (6)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8N6U8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MSLNSSLSCR KELSNLTEEE GGEGGVIITQ FIAIIVITIF VCLGNLVIVV 
        60         70         80         90        100
TLYKKSYLLT LSNKFVFSLT LSNFLLSVLV LPFVVTSSIR REWIFGVVWC 
       110        120        130        140        150
NFSALLYLLI SSASMLTLGV IAIDRYYAVL YPMVYPMKIT GNRAVMALVY 
       160        170        180        190        200
IWLHSLIGCL PPLFGWSSVE FDEFKWMCVA AWHREPGYTA FWQIWCALFP 
       210        220        230        240        250
FLVMLVCYGF IFRVARVKAR KVHCGTVVIV EEDAQRTGRK NSSTSTSSSG 
       260        270        280        290        300
SRRNAFQGVV YSANQCKALI TILVVLGAFM VTWGPYMVVI ASEALWGKSS 
       310        320        330        340        350
VSPSLETWAT WLSFASAVCH PLIYGLWNKT VRKELLGMCF GDRYYREPFV 
       360        370        380        390        400
QRQRTSRLFS ISNRITDLGL SPHLTALMAG GQPLGHSSST GDTGFSCSQD 
       410        420        430        440        450
SGTDMMLLED YTSDDNPPSH CTCPPKRRSS VTFEDEVEQI KEAAKNSILH 
       460        470        480        490        500
VKAEVHKSLD SYAASLAKAI EAEAKINLFG EEALPGVLVT ARTVPGGGFG 
       510        520 
GRRGSRTLVS QRLQLQSIEE GDVLAAEQR

Length:529

Mass (Da):58,559

Last modified:October 1, 2002 - v1

Checksum:ⁱFC7D1AC0894DC3F3

GO

Isoform 2 (identifier: Q8N6U8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
403-407: TDMML → NLRAL
408-529: Missing.

« Hide

        10         20         30         40         50
MSLNSSLSCR KELSNLTEEE GGEGGVIITQ FIAIIVITIF VCLGNLVIVV 
        60         70         80         90        100
TLYKKSYLLT LSNKFVFSLT LSNFLLSVLV LPFVVTSSIR REWIFGVVWC 
       110        120        130        140        150
NFSALLYLLI SSASMLTLGV IAIDRYYAVL YPMVYPMKIT GNRAVMALVY 
       160        170        180        190        200
IWLHSLIGCL PPLFGWSSVE FDEFKWMCVA AWHREPGYTA FWQIWCALFP 
       210        220        230        240        250
FLVMLVCYGF IFRVARVKAR KVHCGTVVIV EEDAQRTGRK NSSTSTSSSG 
       260        270        280        290        300
SRRNAFQGVV YSANQCKALI TILVVLGAFM VTWGPYMVVI ASEALWGKSS 
       310        320        330        340        350
VSPSLETWAT WLSFASAVCH PLIYGLWNKT VRKELLGMCF GDRYYREPFV 
       360        370        380        390        400
QRQRTSRLFS ISNRITDLGL SPHLTALMAG GQPLGHSSST GDTGFSCSQD 

SGNLRAL

Note: No experimental confirmation available.

Show »

Length:407

Mass (Da):45,363

Checksum:ⁱ00078B8EB5BC1F21

GO

Isoform 3 (identifier: Q8N6U8-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-132: Missing.

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        10         20         30         40         50
MVYPMKITGN RAVMALVYIW LHSLIGCLPP LFGWSSVEFD EFKWMCVAAW 
        60         70         80         90        100
HREPGYTAFW QIWCALFPFL VMLVCYGFIF RVARVKARKV HCGTVVIVEE 
       110        120        130        140        150
DAQRTGRKNS STSTSSSGSR RNAFQGVVYS ANQCKALITI LVVLGAFMVT 
       160        170        180        190        200
WGPYMVVIAS EALWGKSSVS PSLETWATWL SFASAVCHPL IYGLWNKTVR 
       210        220        230        240        250
KELLGMCFGD RYYREPFVQR QRTSRLFSIS NRITDLGLSP HLTALMAGGQ 
       260        270        280        290        300
PLGHSSSTGD TGFSCSQDSG TDMMLLEDYT SDDNPPSHCT CPPKRRSSVT 
       310        320        330        340        350
FEDEVEQIKE AAKNSILHVK AEVHKSLDSY AASLAKAIEA EAKINLFGEE 
       360        370        380        390 
ALPGVLVTAR TVPGGGFGGR RGSRTLVSQR LQLQSIEEGD VLAAEQR

Note: No experimental confirmation available.

Show »

Length:397

Mass (Da):43,906

Checksum:ⁱ426288987F5CF53F

GO

Isoform 4 (identifier: Q8N6U8-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-47: MSLNSSLSCR...TIFVCLGNLV → MGGRRCVPGT...APRLESVRTS
48-125: Missing.

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        10         20         30         40         50
MGGRRCVPGT LPMRAAPPGA KRLHVPLRAK GVGRSGHAPR LESVRTSYYA 
        60         70         80         90        100
VLYPMVYPMK ITGNRAVMAL VYIWLHSLIG CLPPLFGWSS VEFDEFKWMC 
       110        120        130        140        150
VAAWHREPGY TAFWQIWCAL FPFLVMLVCY GFIFRVARVK ARKVHCGTVV 
       160        170        180        190        200
IVEEDAQRTG RKNSSTSTSS SGSRRNAFQG VVYSANQCKA LITILVVLGA 
       210        220        230        240        250
FMVTWGPYMV VIASEALWGK SSVSPSLETW ATWLSFASAV CHPLIYGLWN 
       260        270        280        290        300
KTVRKELLGM CFGDRYYREP FVQRQRTSRL FSISNRITDL GLSPHLTALM 
       310        320        330        340        350
AGGQPLGHSS STGDTGFSCS QDSGTDMMLL EDYTSDDNPP SHCTCPPKRR 
       360        370        380        390        400
SSVTFEDEVE QIKEAAKNSI LHVKAEVHKS LDSYAASLAK AIEAEAKINL 
       410        420        430        440        450
FGEEALPGVL VTARTVPGGG FGGRRGSRTL VSQRLQLQSI EEGDVLAAEQ 

R

Note: No experimental confirmation available.

Show »

Length:451

Mass (Da):49,701

Checksum:ⁱ0FAEB6C663961C79

GO

Isoform 5 (identifier: Q8N6U8-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-125: MSLNSSLSCR...LTLGVIAIDR → MLVPVGWMNES

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        10         20         30         40         50
MLVPVGWMNE SYYAVLYPMV YPMKITGNRA VMALVYIWLH SLIGCLPPLF 
        60         70         80         90        100
GWSSVEFDEF KWMCVAAWHR EPGYTAFWQI WCALFPFLVM LVCYGFIFRV 
       110        120        130        140        150
ARVKARKVHC GTVVIVEEDA QRTGRKNSST STSSSGSRRN AFQGVVYSAN 
       160        170        180        190        200
QCKALITILV VLGAFMVTWG PYMVVIASEA LWGKSSVSPS LETWATWLSF 
       210        220        230        240        250
ASAVCHPLIY GLWNKTVRKE LLGMCFGDRY YREPFVQRQR TSRLFSISNR 
       260        270        280        290        300
ITDLGLSPHL TALMAGGQPL GHSSSTGDTG FSCSQDSGTD MMLLEDYTSD 
       310        320        330        340        350
DNPPSHCTCP PKRRSSVTFE DEVEQIKEAA KNSILHVKAE VHKSLDSYAA 
       360        370        380        390        400
SLAKAIEAEA KINLFGEEAL PGVLVTARTV PGGGFGGRRG SRTLVSQRLQ 
       410 
LQSIEEGDVL AAEQR

Show »

Length:415

Mass (Da):46,021

Checksum:ⁱDCC21C091A3A3B4B

GO

Isoform 6 (identifier: Q8N6U8-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MSARGVVQHALPTPRRGALTM

« Hide

        10         20         30         40         50
MSARGVVQHA LPTPRRGALT MSLNSSLSCR KELSNLTEEE GGEGGVIITQ 
        60         70         80         90        100
FIAIIVITIF VCLGNLVIVV TLYKKSYLLT LSNKFVFSLT LSNFLLSVLV 
       110        120        130        140        150
LPFVVTSSIR REWIFGVVWC NFSALLYLLI SSASMLTLGV IAIDRYYAVL 
       160        170        180        190        200
YPMVYPMKIT GNRAVMALVY IWLHSLIGCL PPLFGWSSVE FDEFKWMCVA 
       210        220        230        240        250
AWHREPGYTA FWQIWCALFP FLVMLVCYGF IFRVARVKAR KVHCGTVVIV 
       260        270        280        290        300
EEDAQRTGRK NSSTSTSSSG SRRNAFQGVV YSANQCKALI TILVVLGAFM 
       310        320        330        340        350
VTWGPYMVVI ASEALWGKSS VSPSLETWAT WLSFASAVCH PLIYGLWNKT 
       360        370        380        390        400
VRKELLGMCF GDRYYREPFV QRQRTSRLFS ISNRITDLGL SPHLTALMAG 
       410        420        430        440        450
GQPLGHSSST GDTGFSCSQD SGTDMMLLED YTSDDNPPSH CTCPPKRRSS 
       460        470        480        490        500
VTFEDEVEQI KEAAKNSILH VKAEVHKSLD SYAASLAKAI EAEAKINLFG 
       510        520        530        540 
EEALPGVLVT ARTVPGGGFG GRRGSRTLVS QRLQLQSIEE GDVLAAEQR

Show »

Length:549

Mass (Da):60,659

Checksum:ⁱ6FDA02198DEB9F8F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	193	Q → R in BAH12873 (PubMed:14702039).Curated	1
Sequence conflictⁱ	195	W → R in BAH13082 (PubMed:14702039).Curated	1
Sequence conflictⁱ	324	Y → N in BAH12873 (PubMed:14702039).Curated	1
Sequence conflictⁱ	421	C → S in BAH13082 (PubMed:14702039).Curated	1
Sequence conflictⁱ	500	G → V in BAH12873 (PubMed:14702039).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_035561	1 – 132	Missing in isoform 3. 1 PublicationAdd BLAST	132
Alternative sequenceⁱVSP_045329	1 – 125	MSLNS…IAIDR → MLVPVGWMNES in isoform 5. 1 PublicationAdd BLAST	125
Alternative sequenceⁱVSP_044778	1 – 47	MSLNS…LGNLV → MGGRRCVPGTLPMRAAPPGA KRLHVPLRAKGVGRSGHAPR LESVRTS in isoform 4. 1 PublicationAdd BLAST	47
Alternative sequenceⁱVSP_046299	1	M → MSARGVVQHALPTPRRGALT M in isoform 6. 1 Publication	1
Alternative sequenceⁱVSP_044779	48 – 125	Missing in isoform 4. 1 PublicationAdd BLAST	78
Alternative sequenceⁱVSP_010560	403 – 407	TDMML → NLRAL in isoform 2. 1 Publication	5
Alternative sequenceⁱVSP_010561	408 – 529	Missing in isoform 2. 1 PublicationAdd BLAST	122

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY275468 mRNA. Translation: AAP32300.1. AF091890 mRNA. Translation: AAC61598.1. AK056040 mRNA. Translation: BAG51611.1. AK122656 mRNA. Translation: BAG53646.1. AK298797 mRNA. Translation: BAH12873.1. AK298850 mRNA. Translation: BAH12884.1. AK299634 mRNA. Translation: BAH13082.1. AL033532 Genomic DNA. Translation: CAI22622.1. AL033532 Genomic DNA. Translation: CAI22623.1. BC028163 mRNA. Translation: AAH28163.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1268.1. [Q8N6U8-1] CCDS58042.1. [Q8N6U8-3] CCDS58043.1. [Q8N6U8-6] CCDS58044.1. [Q8N6U8-4] CCDS58045.1. [Q8N6U8-5]
NCBI Reference Sequences More...RefSeqⁱ	NP_001254538.1. NM_001267609.1. [Q8N6U8-6] NP_001254539.1. NM_001267610.1. [Q8N6U8-1] NP_001254541.1. NM_001267612.1. [Q8N6U8-3] NP_001254542.1. NM_001267613.1. [Q8N6U8-4] NP_001254543.1. NM_001267614.1. [Q8N6U8-5] NP_722561.1. NM_153832.2. [Q8N6U8-1] XP_005245112.1. XM_005245055.2. [Q8N6U8-6] XP_005245113.1. XM_005245056.2. [Q8N6U8-1] XP_005245114.1. XM_005245057.4. [Q8N6U8-1] XP_011507677.1. XM_011509375.2. [Q8N6U8-1] XP_011507678.1. XM_011509376.2. [Q8N6U8-1] XP_011507679.1. XM_011509377.1. [Q8N6U8-1] XP_011507680.1. XM_011509378.1. [Q8N6U8-1] XP_016856348.1. XM_017000859.1. [Q8N6U8-6] XP_016856349.1. XM_017000860.1. [Q8N6U8-1] XP_016856350.1. XM_017000861.1. [Q8N6U8-1] XP_016856351.1. XM_017000862.1. [Q8N6U8-1]
UniGeneⁱ	Hs.271809.

Genome annotation databases

Ensemblⁱ	ENST00000367835; ENSP00000356809; ENSG00000143147. [Q8N6U8-1] ENST00000367836; ENSP00000356810; ENSG00000143147. [Q8N6U8-3] ENST00000367838; ENSP00000356812; ENSG00000143147. [Q8N6U8-1] ENST00000537209; ENSP00000441039; ENSG00000143147. [Q8N6U8-6] ENST00000539777; ENSP00000437576; ENSG00000143147. [Q8N6U8-4] ENST00000546300; ENSP00000444348; ENSG00000143147. [Q8N6U8-5]
GeneIDⁱ	23432.
KEGGⁱ	hsa:23432.
UCSC genome browser More...UCSCⁱ	uc001gfb.5. human. [Q8N6U8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q8N6U8	Q8N6U8-3 UPI0007DC7DF4	Homo sapiens (Human)	529	UniRef100_Q8N6U8	Cluster: G-protein coupled receptor 161	3

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q8N6U8	B2RPY5-3 Q8N6U8-3 UPI0007DC7DF4 A0A140T8Q9 B2RPY5-2	Homo sapiens (Human) Mus musculus (Mouse)	558	UniRef90_B2RPY5-3	Cluster: Isoform 3 of G-protein coupled receptor 161	6
Q8N6U8-4	A0A1D5QQN4 UPI0002ADB5FB UPI0004F05C59 UPI0005F4408F F6V447 UPI00045DA64B UPI0005334F66 A0A1U7UKF4 UPI0005F45E77 UPI0005F41965 +13	Macaca mulatta (Rhesus macaque) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Pan paniscus (Pygmy chimpanzee) (Bonobo) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Callithrix jacchus (White-tufted-ear marmoset) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Tarsius syrichta (Philippine tarsier) Macaca nemestrina (Pig-tailed macaque) Mandrillus leucophaeus (Drill) (Papio leucophaeus) And more	451	UniRef90_Q8N6U8-4	Cluster: Isoform 4 of G-protein coupled receptor 161	24
Q8N6U8-5	Q8N6U8-4 A0A1D5QQN4 UPI0002ADB5FB UPI0004F05C59 UPI0005F4408F F6V447 UPI00045DA64B UPI0005334F66 A0A1U7UKF4 UPI0005F45E77 +13	Macaca mulatta (Rhesus macaque) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Pan paniscus (Pygmy chimpanzee) (Bonobo) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Callithrix jacchus (White-tufted-ear marmoset) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Tarsius syrichta (Philippine tarsier) Macaca nemestrina (Pig-tailed macaque) Mandrillus leucophaeus (Drill) (Papio leucophaeus) And more	451	UniRef90_Q8N6U8-4	Cluster: Isoform 4 of G-protein coupled receptor 161	24
Q8N6U8-6	UPI000643A00A UPI0001774C4B A0A1D5QRN0 UPI00083C44B6	Microcebus murinus (Lesser mouse lemur) (Gray Mouse Lemur) Macaca mulatta (Rhesus macaque) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)	549	UniRef90_Q8N6U8-6	Cluster: Isoform 6 of G-protein coupled receptor 161	5

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q8N6U8	B2RPY5 UPI0005F55EE2 UPI0005F56C23 UPI00083C6E60 UPI00083C7B81 UPI0000E05E7C UPI00045DEEC2 UPI00077DD1B4 UPI0007045271 UPI0002C5455B +301	Mus musculus (Mouse) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Homo sapiens (Human) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Peromyscus maniculatus bairdii (prairie deer mouse) Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus) Odobenus rosmarus divergens (Pacific walrus) Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli) Papio anubis (Olive baboon) And more	545	UniRef50_B2RPY5	Cluster: G-protein coupled receptor 161	312
Q8N6U8-2	UPI0003339E17 UPI00042CA83A G3HE60 UPI0004543CBC UPI0003502388 UPI0007687661 F7A4B9 UPI0006D8E38D UPI00064D51FA F6U8L1 +3	Echinops telfairi (Lesser hedgehog tenrec) Bubalus bubalis (Domestic water buffalo) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Heterocephalus glaber (Naked mole rat) Pteropus alecto (Black flying fox) Ornithorhynchus anatinus (Duckbill platypus) Latimeria chalumnae (West Indian ocean coelacanth) Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) Pteropus vampyrus (Large flying fox)	407	UniRef50_Q8N6U8-2	Cluster: Isoform 2 of G-protein coupled receptor 161	14
Q8N6U8-4	UPI0005F4408F UPI0002ADB5FB UPI0004F05C59 A0A1D5QQN4 F6V447 UPI00045DA64B UPI0005334F66 A0A1U7UKF4 UPI0005F41965 UPI0005F45E77 +87	Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Pan paniscus (Pygmy chimpanzee) (Bonobo) Macaca mulatta (Rhesus macaque) Callithrix jacchus (White-tufted-ear marmoset) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Tarsius syrichta (Philippine tarsier) Macaca nemestrina (Pig-tailed macaque) Loxodonta africana (African elephant) And more	451	UniRef50_Q8N6U8-4	Cluster: Isoform 4 of G-protein coupled receptor 161	98
Q8N6U8-5	Q8N6U8-4 UPI0005F4408F UPI0002ADB5FB UPI0004F05C59 A0A1D5QQN4 F6V447 UPI00045DA64B UPI0005334F66 A0A1U7UKF4 UPI0005F41965 +87	Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Pan paniscus (Pygmy chimpanzee) (Bonobo) Macaca mulatta (Rhesus macaque) Callithrix jacchus (White-tufted-ear marmoset) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Tarsius syrichta (Philippine tarsier) Macaca nemestrina (Pig-tailed macaque) Loxodonta africana (African elephant) And more	451	UniRef50_Q8N6U8-4	Cluster: Isoform 4 of G-protein coupled receptor 161	98

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY275468 mRNA. Translation: AAP32300.1. AF091890 mRNA. Translation: AAC61598.1. AK056040 mRNA. Translation: BAG51611.1. AK122656 mRNA. Translation: BAG53646.1. AK298797 mRNA. Translation: BAH12873.1. AK298850 mRNA. Translation: BAH12884.1. AK299634 mRNA. Translation: BAH13082.1. AL033532 Genomic DNA. Translation: CAI22622.1. AL033532 Genomic DNA. Translation: CAI22623.1. BC028163 mRNA. Translation: AAH28163.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1268.1. [Q8N6U8-1] CCDS58042.1. [Q8N6U8-3] CCDS58043.1. [Q8N6U8-6] CCDS58044.1. [Q8N6U8-4] CCDS58045.1. [Q8N6U8-5]
NCBI Reference Sequences More...RefSeqⁱ	NP_001254538.1. NM_001267609.1. [Q8N6U8-6] NP_001254539.1. NM_001267610.1. [Q8N6U8-1] NP_001254541.1. NM_001267612.1. [Q8N6U8-3] NP_001254542.1. NM_001267613.1. [Q8N6U8-4] NP_001254543.1. NM_001267614.1. [Q8N6U8-5] NP_722561.1. NM_153832.2. [Q8N6U8-1] XP_005245112.1. XM_005245055.2. [Q8N6U8-6] XP_005245113.1. XM_005245056.2. [Q8N6U8-1] XP_005245114.1. XM_005245057.4. [Q8N6U8-1] XP_011507677.1. XM_011509375.2. [Q8N6U8-1] XP_011507678.1. XM_011509376.2. [Q8N6U8-1] XP_011507679.1. XM_011509377.1. [Q8N6U8-1] XP_011507680.1. XM_011509378.1. [Q8N6U8-1] XP_016856348.1. XM_017000859.1. [Q8N6U8-6] XP_016856349.1. XM_017000860.1. [Q8N6U8-1] XP_016856350.1. XM_017000861.1. [Q8N6U8-1] XP_016856351.1. XM_017000862.1. [Q8N6U8-1]
UniGeneⁱ	Hs.271809.

3D structure databases

ProteinModelPortalⁱ	Q8N6U8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117000. 16 interactors.
IntActⁱ	Q8N6U8. 1 interactor.
STRINGⁱ	9606.ENSP00000271357.

Protein family/group databases

TCDBⁱ	9.A.14.1.11. the g-protein-coupled receptor (gpcr) family.
GPCRDBⁱ	Search...

PTM databases

iPTMnetⁱ	Q8N6U8.
PhosphoSitePlusⁱ	Q8N6U8.

Polymorphism and mutation databases

BioMutaⁱ	GPR161.
DMDMⁱ	48428085.

Proteomic databases

PaxDbⁱ	Q8N6U8.
PeptideAtlas More...PeptideAtlasⁱ	Q8N6U8.
PRIDEⁱ	Q8N6U8.
TopDownProteomicsⁱ	Q8N6U8-1. [Q8N6U8-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23432.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000367835; ENSP00000356809; ENSG00000143147. [Q8N6U8-1] ENST00000367836; ENSP00000356810; ENSG00000143147. [Q8N6U8-3] ENST00000367838; ENSP00000356812; ENSG00000143147. [Q8N6U8-1] ENST00000537209; ENSP00000441039; ENSG00000143147. [Q8N6U8-6] ENST00000539777; ENSP00000437576; ENSG00000143147. [Q8N6U8-4] ENST00000546300; ENSP00000444348; ENSG00000143147. [Q8N6U8-5]
GeneIDⁱ	23432.
KEGGⁱ	hsa:23432.
UCSC genome browser More...UCSCⁱ	uc001gfb.5. human. [Q8N6U8-1]

Organism-specific databases

CTDⁱ	23432.
DisGeNET More...DisGeNETⁱ	23432.
GeneCardsⁱ	GPR161.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23694. GPR161.
Human Protein Atlas More...HPAⁱ	HPA015576. HPA072047.
MalaCards human disease database More...MalaCardsⁱ	GPR161.
MIMⁱ	612250. gene.
neXtProtⁱ	NX_Q8N6U8.
Open Targets More...OpenTargetsⁱ	ENSG00000143147.
PharmGKBⁱ	PA134931474.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656. Eukaryota. ENOG410XRW9. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137933.
HOGENOMⁱ	HOG000112777.
HOVERGENⁱ	HBG051789.
InParanoidⁱ	Q8N6U8.
KEGG Orthology (KO) More...KOⁱ	K08439.
OMAⁱ	IWCALLP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G56.
PhylomeDBⁱ	Q8N6U8.
TreeFamⁱ	TF331895.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5610787. Hedgehog 'off' state. R-HSA-5632684. Hedgehog 'on' state.

Reactomeⁱ

R-HSA-5610787. Hedgehog 'off' state.
R-HSA-5632684. Hedgehog 'on' state.

Miscellaneous databases

ChiTaRSⁱ	GPR161. human.
GeneWikiⁱ	GPR161.
GenomeRNAiⁱ	23432.
Protein Ontology More...PROⁱ	PR:Q8N6U8.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000143147.
CleanExⁱ	HS_GPR161.
ExpressionAtlasⁱ	Q8N6U8. baseline and differential.
Genevisibleⁱ	Q8N6U8. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GP161_HUMAN
Accessionⁱ	Q8N6U8Primary (citable) accession number: Q8N6U8 Secondary accession number(s): B3KV34 Q5TGK2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
	Last sequence update:	October 1, 2002
	Last modified:	June 7, 2017
	This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q8N6U8 (GP161_HUMAN)

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G-protein coupled receptor 161

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href="https://web.archive.org/help/function_section" target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href="https://web.archive.org/help/gene_ontology" target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href="https://web.archive.org/help/gene_ontology" target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href="https://web.archive.org/help/names_and_taxonomy_section" target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href="https://web.archive.org/help/subcellular_location_section" target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href="https://web.archive.org/help/gene_ontology" target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href="https://web.archive.org/help/pathology_and_biotech_section" target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href="https://web.archive.org/help/ptm_processing_section" target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href="https://web.archive.org/help/expression_section" target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href="https://web.archive.org/help/interaction_section" target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href="https://web.archive.org/help/structure_section" target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href="https://web.archive.org/help/family_and_domains_section" target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href="https://web.archive.org/help/sequence_similarities" target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href="https://web.archive.org/help/cross_references_section" target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href="https://web.archive.org/help/entry_information_section" target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href="https://web.archive.org/help/miscellaneous_section" target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ