Fort Myers in Lee County has been the spring-training home of the Boston Red Sox since 1993, when the team moved from Winter Haven (now the spring-training home of the Cleveland Indians). The Red Sox train at City of Palms Park, while the minor-league facility, featuring five full fields, is a short distance away. 

The stadium is done in a pure Florida style, with a main covered grandstand and palm trees past the outfield fence. There are two sections separated by a concourse: the section closest to the action contains box seats and the section past the concourse contains bleachers. The complex contains a 9,000-square-foot visiting-team clubhouse, and four enclosed batting tunnels. The facility also features administrative offices, three executive booths, and complete media facilities. It was designed by HOK Sport, the architect of many other pro stadiums across the country.

The stadium is also used by the Gulf Coast Rookie League's Red Sox.

The Minnesota Twins also spend spring training in Fort Myers.

The Boston Red Sox have trained in the following locations: Charlottesville, Va. (1901); Augusta, Ga. (1902); Macon, Ga. (1903-1906); Little Rock (1907-1908); Hot Springs, Ark. (1909-1910); Redondo Beach, Cal. (1911); Hot Springs, Ark. (1912-1918); Tampa (1919); Hot Springs, Ark. (1920-1923); San Antonio (1924); New Orleans (1925-1927); Bradenton (1928-1929); Pensacola, Fla. (1930-1931); Savannah (1932); Sarasota (1933-1942); Medford, Mass. (1943-1944); Atlantic City (1945); Sarasota (1946-1958); Scottsdale (1959-1965); Winter Haven (1966-1992); Ft. Myers (1993-present).

The Red Sox have been training at City of Palms Park since the ballpark opened.