Papers by Hamid Golchoubian
Iranian Journal of Chemistry & Chemical Engineering-international English Edition, Jun 1, 2014
Nickel(II) complex of [NiL 2 ](ClO 4 ) 2 , where L is an unsymmetrical tridentate ligand of 2-(2-... more Nickel(II) complex of [NiL 2 ](ClO 4 ) 2 , where L is an unsymmetrical tridentate ligand of 2-(2-aminoethyl)imino-3-butanone oximehas been synthesized by a template condensation reaction. The complex was characterized on the basis of microanalytical, spectroscopic, and other physicochemical properties. X-ray diffraction study of the complex reveals nickel(II) center in a distorted octahedral environment through two amine nitrogen donors, two imine donors, and two nitrogen atoms of the oxime moieties of the ligand. The antibacterial activity of the complex has been tested against Gram(+) and Gram(-) bacteria. The results of the antibacterial screening indicated that the complex is effective against bacterial growth retardation activity to some extent and its effectiveness is higher forGram(+) bacteria.
A symmetric complex [NiL2(H2O)2]Cl2, where L = 2-picolylamine was synthesized and characterized b... more A symmetric complex [NiL2(H2O)2]Cl2, where L = 2-picolylamine was synthesized and characterized by spectroscopic and structural methods. Single crystal X-ray studies reveal that the Ni(II) center located in a pseudo-octahedral N4O2 environment with bidentate ligands L positioned in basal and two water molecules in the apical position. The complex is solvatochromic, ionochromic and thermochromic. The observed positive solvatochromism in polar solvents is due to the substitution of water molecules by the solvent. The complex demonstrated distinct ionochromism towards cyanide and bromide anions in the presence of other halides and pseudo-halide anions and can be served as a ‘‘naked-eye’’ indicator for the qualitative detection of these anions. The compound showed reversible thermochromism in solid-state from blue to green due to dehydration and hydration process.
Three new heteroleptic copper(II) complexes, [(tmen)Cu(dike)H2O]X where tmen = N,N,N',N'-... more Three new heteroleptic copper(II) complexes, [(tmen)Cu(dike)H2O]X where tmen = N,N,N',N'-tetramethylethylenediamine, dike = 2-acetylcyclopentanone anion and X= ClO4- (1), Cl- (2) and Br- (3) are prepared and characterized by elemental analyses, molar conductance measurements and IR and UV-Vis spectroscopy techniques. The complex 1 is fairly soluble in various organic solvents and demonstrates distinctive solvatochromism. However, the solubility of complexes 2 and 3 is less than 1 and their color changes are limited to polar solvents. The influence of the solvent polarity and counter ions on the wave length maxima, max values of the d-d bands of the complexes have been investigated by visible spectroscopy. A multi-parametric equation has been utilized to explain the solvent effect on the d-d transition of [(tmen)Cu(dike H2O)]ClO4 using SPSS/PC software. The stepwise multiple linear regression (SMLR) method demonstrated that the donor power of the solvent plays the most impor...
A series of new heteroleptic chelated copper(II) complexes that encompass N,N-dibezyl substituted... more A series of new heteroleptic chelated copper(II) complexes that encompass N,N-dibezyl substituted derivative of ethylenediamine (X-diamine) and acetylacetonate (acac) were prepared. The IR and electronic absorption spectra and the molar conductivity of the complexes are presented and discussed. The molar conductivity values of the complexes in different solvents reveals a predominance of electrostatic interactions between [Cu(X-diamine)(acac)]+ entity and tetraphenylborate anions that counterbalance the positive charge. The resulting complexes with local symmetry of CuO2N2 attain a square-coplanar structure and exhibit the tendency for axial ligation, which is enhanced when an electron-attracting substituent is attached to the phenyl ring of the ethylenediamine chelate. The tendency for axial ligation is particularly fulfilled when suitable nucleophiles (solvents) with different donor abilities exist, leading to solvatochromism. The solute-solvent interactions are revealed by s...
Journal of Coordination Chemistry, 2016
X-ray Structure Analysis Online, 2009
The crystal structure of N,N¢-dipyridyl-N, N¢-ethylenedi(5-bromo-3-formyl-2-hydroxybenzylamine) w... more The crystal structure of N,N¢-dipyridyl-N, N¢-ethylenedi(5-bromo-3-formyl-2-hydroxybenzylamine) was determined by single-crystal X-ray diffraction. The compound crystallizes in a monoclinic system and was characterized thus: C2/c, a = 17.6158( ), b = 9.2327(7), c = 17.6983(13)Å, b = 102.771(2)˚, Z = 4, V = 2807.3(4)Å 3 . The crystal structure was solved by direct methods and refined by full-matrix least-squares on F 2 to final values of R1 = 0.0557 and wR2 = 0.0648. The complex consists of monomeric units with a coordination sphere of CoN4O2 type. The geometry around cobalt(II) is distorted octahedral with two amine nitrogen donors, two cis-phenolic oxygen donors, and two trans-pyridine nitrogen atoms.
X-ray Structure Analysis Online, 2009
Analytical Sciences: X-ray Structure Analysis Online, 2008
C21H25Br2ClCuN2O6 is tetragonal, P43212; the unit-cell parameters at 120(2)K are a = 13.5447(3)Å,... more C21H25Br2ClCuN2O6 is tetragonal, P43212; the unit-cell parameters at 120(2)K are a = 13.5447(3)Å, c = 13.6524(7)Å, Z = 4, V = 2504.65(15)Å 3 and Dx = 1.751 g cm -3 . The final R value was R1 = 0.0259 for 2480 reflections with I > 2s(I). The complex cation is nearly planar and has a 2-fold symmetry and constructed from mixed-chelates of diamine and acetylacetonate. Two ClO4 -ions are bound weakly above and below of the chelate plane, so that the coordination environment around the copper ion is approximately octahedral. The five-membered ring containing nitrogen and carbon atoms is puckered.
Analytical Sciences: X-ray Structure Analysis Online, 2008
The title compound was synthesized and characterized by single-crystal X-ray diffraction. This co... more The title compound was synthesized and characterized by single-crystal X-ray diffraction. This complex was solved in the tetragonal system, space group P41212, with the following unit-cell parameters: a = 13.6010(3)Å, c = 13.1885(6)Å, Z = 4, V = 2439.70(13)Å 3 . The final R value was R1 = 0.0259 for 27567 measured reflections.
Iranica Journal of Energy & Environment, 2012
Solvatochromic properties of a series of bis(3-substituted derivatives of acetylacetone)copper(II... more Solvatochromic properties of a series of bis(3-substituted derivatives of acetylacetone)copper(II) (X-acacH , X = Cl, H. CH ) complexes were studied. All the complexes demonstrated negative solvatochromism. 3 Among the complexes the Cu(Cl-acac) , demonstrated the most solvatochromism. A multi-parametric equation 2 has been utilized to explain the solvent effect on the d-d transition of the complexes using SPSS/PC software. The stepwise multiple linear regression (SMLR) method demonstrated that the donor power of the solvent plays the most important role in the solvatochromism of the compounds.
Bulletin of the Chemical Society of Ethiopia, 2010
A convenient and more efficient method for the preparation of 1,6-bis(2-pyridyl)-2,5-bis(2hydroxy... more A convenient and more efficient method for the preparation of 1,6-bis(2-pyridyl)-2,5-bis(2hydroxy-3-formyl-5-methyl benzyl)-2,5-diazahexane, L 1 H2 and 1,7-bis(2-pyridyl)-2,6-bis(2-hydroxy-3-formyl-5methyl benzyl)-2,6-diazaheptane, L 2 H2 are described. The ligands were prepared by reaction of two moles of 3-(chloromethyl)-2-hydroxy-5-methyl benzaldehyde with a mole of N,N'-bis(2-pyridyl)dopamine in THF at ambient conditions in high yield (75-80%).
Crystal and Molecular Structure of a Cu(II) Complex with Macrocyclic Ligand of 10,12-dibromo-6-ethylcyanide-3,6,14,18-tetraazapentaicosa-1(25), 8(24),10,12,13,19,21,23-octaene-24,25-diol X-ray Structure Analysis Online, 2011
X-ray Structure Analysis Online, 2009
Aminonitriles, resulting from the reaction between carbonyl compounds and amines, and a cyanide s... more Aminonitriles, resulting from the reaction between carbonyl compounds and amines, and a cyanide source are significantly important intermediates for the synthesis of a wide variety of amino acids, amides, diamines and nitrogen-containing heterocycles. 1 Despite this high level of interest, the majority of studies in the synthesis of aminonitriles are focused to utilize aromatic amines or their derivatives in the Strecker reaction, and only few reports are available involving the use of aliphatic amines. 2,3 Additionally, based on our knowledge, there are only a few reports on the preparation and study of diaminonitriles. 4 Diaminonitriles are of interest due to their tetra-dentate bifunctional nature and chelating effects as well as their applications in coordination chemistry via different coordination modes of the cyanide group to metal ions. 5 Herein, we wish to report on the crystal structure of a new diaminonitrile, shown below (Fig. ). The title compound, N,N-butylene-bis(2-phenyl)glycinonitrile, was synthesized in good yield by mixing two equivalents, benzaldehyde and an equivalent 1,4-diaminobutane, in an aqueous solution of sodium hydrogensulfite (two equivalents). The resultant mixture was heated to 50 -60˚C until a homogenous solution was formed. Subsequently, an aqueous solution of sodium cyanide (two equivalents) was added thereto. The desired diaminonitrile was precipitated almost immediately. A crystal suitable for X-ray structural determination was grown from hot ethanol. The structure was solved by automated direct methods using SHELXS-2001, and refined by a full-matrix least squares analysis on F 2 with SHELXL-2001. 6 The absorption was performed semi-empirically from an equivalent by means of the SADABS program. 7 The non-hydrogen atoms were refined anisotropically, and all of the hydrogen atoms participating in hydrogen bonds were located from the difference Fourier X-ray Structure Analysis Online
Spectroscopic studies on Solvatochromism of mixed-chelate copper(II) complexes using MLR technique
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2012
Mixed-chelate copper(II) complexes with a general formula [Cu(acac)(diamine)]X where acac=acetyla... more Mixed-chelate copper(II) complexes with a general formula [Cu(acac)(diamine)]X where acac=acetylacetonate ion, diamine=N,N-dimethyl,N'-benzyl-1,2-diaminoethane and X=BPh(4)(-), PF(6)(-), ClO(4)(-) and BF(4)(-) have been prepared. The complexes were characterized on the basis of elemental analysis, molar conductance, UV-vis and IR spectroscopies. The complexes are solvatochromic and their solvatochromism were investigated by visible spectroscopy. All complexes demonstrated the positive solvatochromism and among the complexes [Cu(acac)(diamine)]BPh(4)·H(2)O showed the highest Δν(max) value. To explore the mechanism of interaction between solvent molecules and the complexes, different solvent parameters such as DN, AN, α and β using multiple linear regression (MLR) method were employed. The statistical results suggested that the DN parameter of the solvent plays a dominate contribution to the shift of the d-d absorption band of the complexes.
Synthesis of Dinuclear Thiolate-Bridged Macrocyclic Nickel(II) Complexes with C2 Linker Diimine
Phosphorus, Sulfur, and Silicon and the Related Elements, 2006
... Fatemeh Farsavi Hamid Golchoubian Department of Chemistry, University of Mazandaran, Babolsar... more ... Fatemeh Farsavi Hamid Golchoubian Department of Chemistry, University of Mazandaran, Babolsar, Iran ... set to N4S2 might increase the ligand-field strength of the macrocyclic due to the potential π back-donation and the weaker σ-donor abilities of RS − compared to RO − . ...
Molecules, 2007
A "green" highly selective oxidation of organic sulfides to the corresponding sulfoxides was deve... more A "green" highly selective oxidation of organic sulfides to the corresponding sulfoxides was developed using hydrogen peroxide and glacial acetic acid under transition metal-free and mild conditions. The oxidation procedure is very simple and the products are easily isolated in excellent yields (90-99%).
Chemoselective and Efficient Method for Deprotection of THP and Silyl Ethers with H2O2/ Mn(III) Schiff-Base Complex
Letters in Organic Chemistry, 2008
... Chemoselective and Efficient Method for Deprotection of THP and Silyl Ethers with H2O2/ Mn(II... more ... Chemoselective and Efficient Method for Deprotection of THP and Silyl Ethers with H2O2/ Mn(III) Schiff-Base Complex Mahmood Tajbakhsh*, Rahman Hosseinzadeh, Hamid Golchoubian and Raheleh Razavian ... Chem., 2004, 12, 903. [23] Mardani, HR; Golchoubian, H. J. Mol. ...
Production, quality control and pharmacokinetic studies of 177Lu–zoledronate for bone pain palliation therapy
Journal of Radioanalytical and Nuclear Chemistry, 2013
ABSTRACT Developing new bone pain palliation agents are a mandate in handling end-stage cancer pa... more ABSTRACT Developing new bone pain palliation agents are a mandate in handling end-stage cancer patient’s around the world. 177Lu (1-hydroxy-2-imidazol-1-yl-phosphonoethyl)phosphonic acid (177Lu–ZLD) is a possible therapeutic agent which can be used in bone palliation therapy. In this study, 177Lu–ZLD complex was prepared successfully using commercial ZLD ligand and 177LuCl3 at 25 and 60 °C at various ligand:metal ratios for 60–360 min. 177Lu chloride was obtained by thermal neutron irradiation (4 × 1013 n cm−2s−1) of natural Lu2O3 samples. Radiochemical purity of 177Lu–ZLD was checked by ITLC and HPLC. Stability studies of final preparation in the presence of human serum were performed as well as protein binding studies and hydroxyapatite (HA) binding test. The biodistribution of 177Lu–ZLD and 177LuCl3 in mice were determined for 7 days. A comparative accumulation study for 177Lu–ZLD and 177Lu–EDTMP was performed for vital organs up to 7 days. The complex was obtained in high radiochemical purity ITLC (>97 %) and HPLC (>99.9 %) and satisfactory stability in presence of human serum and final formulations were obtained (≈90 % in 48 h). HA binding assay demonstrated >95 % binding from 5 to 20 mg of HA in 24 h at room temperature. The complex protein binding was about 55–58 %. The high bone uptake ratios at all time intervals was obtained (>9 % at day 7), bone:kidney and bone:liver uptake ratios were significantly high for ZLD at 7 day post injection but not superior to 177Lu–EDTMP. Due to longer physical half life of 177Lu compared to 153Sm and comparable ratios for 177Lu–ZLD compared to 177Lu–EDTMP, 177Lu–ZLD can be an interesting new candidate for clinical trials for bone pain palliation therapy.
Substituent and solvent effects in the spectra of new mixed-chelate copper (II) complexes containing N,N′-disubstituted ethylenediimine and acetylacetonate ligands
Journal of Molecular Structure, 2006
Four mixed-chelate copper (II) complexes containing acetylacetonate ion and various diimine ligan... more Four mixed-chelate copper (II) complexes containing acetylacetonate ion and various diimine ligand were prepared and characterized by elemental analysis, spectroscopic and molar conductance measurements. These complexes are fairly soluble in various solvents and show positive solvatochromism. The examinations of the electronic properties of the groups attached to the diimine chelate on the solvatochromic behavior of these complexes were investigated.
Chromotropism of a new mixed-chelate copper(II) complex
Journal of Molecular Structure, 2009
... Selected IR data (ν/cm −1 using KBr): 3370 (m, NH str.), 2810 (s, CH str. aliphatic), 1475 ... more ... Selected IR data (ν/cm −1 using KBr): 3370 (m, NH str.), 2810 (s, CH str. aliphatic), 1475 (s, PhO str.), 680 (m, CCH 3 + ring def. + CuO). 1 H NMR (500 MHz, CDCl 3 ), δ: 2.19 (s, 6H, CH 3 ); 2.42 (t, J = 6.0 Hz, 2H, CH 2 ); 2.69 (t, J = 6.0 Hz, H, CH 2 ); 3.80 (s, 2H, CH 2 Ph ...
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Papers by Hamid Golchoubian