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Intelligence And Longevity Share Genetic Roots, Shows Study Of 400,000 People
In A Nutshell
- Genes that boost childhood intelligence also predict longer lifespans in parents; about a third of the genetic influences overlap between the two traits.
- Kids who score higher on intelligence tests tend to live longer, and this new study shows inherited DNA helps explain why.
- The genetic link could work two ways: either certain genes directly build healthier bodies and brains, or intelligence genes lead to better education and life circumstances that add years.
- The study analyzed nearly 400,000 people but can’t yet pinpoint which specific genes create this connection—that’s the next step for researchers.
The same genes that make kids score higher on intelligence tests are also linked to parents living longer lives. That’s the finding from a new study that analyzed genetic data from nearly 400,000 people. The results suggest intelligence and longevity aren’t just connected by lifestyle choices; rather, they may share biological roots.
Researchers at the University of Edinburgh looked at genetic data from 12,441 children who took cognitive tests and compared it with how long 389,166 parents lived. They found that about a third of the genetic influences on childhood intelligence overlap with those affecting how long people live.
Here’s the key: Parents pass their genes to their kids. Some of those genes affect how well children do on thinking tests. The study found that those same genes (the ones parents carry) are also tied to parents living longer. It’s not that smart kids somehow make their parents live longer. Instead, certain genes seem to influence both traits at once.
Scientists have known for decades that kids who score higher on intelligence tests tend to live longer, healthier lives. But figuring out why has been tricky. This study, published in Genomic Psychiatry, adds genetic evidence to the puzzle, showing that at least part of the answer lies in shared DNA.

Why Children’s Intelligence Predicts Parents’ Lifespans
Earlier genetic studies looked at intelligence measured in adults and found similar patterns. But those studies left an important question open: What if declining health in middle age was affecting both test scores and lifespan at the same time?
The Edinburgh researchers sidestepped that problem by focusing on intelligence tests taken in childhood, long before most health problems show up. They then looked at how long the parents of those children lived. Since the same genes pass from parent to child, finding a link between kids’ intelligence genes and parents’ lifespans reveals a real genetic connection, one that exists regardless of later-life health issues.
The research team used a technique that examines patterns across the entire genome to calculate how much genetic overlap exists between two traits. They didn’t need to identify specific genes, just measure how much the overall genetic patterns matched up.
The results showed that common genetic differences explained about 27% of the variation in children’s test scores. Similar genetic differences explained about 29% of the variation in how long parents lived. When they compared these patterns, they found significant overlap.
An earlier study that looked at adult intelligence and longevity found nearly identical results. That consistency across different age groups strengthens the case that shared genetics help connect intelligence to lifespan.
How Genes Might Link Smarts to Survival
The genetic overlap between children’s intelligence and parental longevity could work through two different mechanisms, both involving what scientists call pleiotropy. Pleiotropy occurs when a single gene or genetic variant influences multiple traits simultaneously.
In the first scenario, some genes directly affect both your brain and your overall health. Think of it as genetic quality control. People who inherit certain genetic variants might get bodies and brains that simply run better and last longer. Scientists call this the “system integrity” hypothesis; some genetic profiles just produce healthier systems all around.
The second scenario is more indirect. Genes that boost childhood intelligence might lead to better education, which opens doors to higher-paying jobs, safer neighborhoods, and healthier lifestyles. Those advantages pile up over time and contribute to longer lives. Research has shown that intelligence does appear to cause higher educational achievement, and education is one of the strongest predictors of better health.
The current study can’t tell which explanation is right. Most likely, both are playing a role.
What A Million People Tell Us
The genetic findings match up with decades of traditional research on intelligence and longevity. Long-term studies from the UK, Denmark, Israel, and Sweden have tracked participants for anywhere from 17 to 69 years, and they all show the same pattern.
A review of 16 studies pooled data from over 1 million people, including 22,453 deaths. The finding: For every standard deviation increase in childhood intelligence test scores (roughly the difference between an average score and a good score) mortality risk dropped by 24% on average. That pattern held across different intelligence levels and showed up in both men and women. It persisted even when researchers accounted for family income in childhood, and only weakened slightly when they factored in education and career.
The genetic correlation found in the new study provides evidence that inherited DNA helps drive this pattern. The same genetic variants that help kids score higher on tests are also helping their parents live longer lives.
What We Still Don’t Know
The research comes with important caveats. The genetic correlation describes an average effect across most of the genome but doesn’t pinpoint which specific genes or biological systems create this connection. The analysis can’t determine whether one mechanism or both are at work.
The study looked only at regular chromosomes, not sex chromosomes (X and Y). Any genetic effects specific to those chromosomes would have been missed. Future research will need to identify the exact genes involved and figure out how they actually work.
It’s also worth remembering that longevity depends on many factors beyond genetics. Access to healthcare, lifestyle choices, accidents, and plain luck all play major roles. Genes account for less than a third of the differences in how long people live, based on this study’s estimates.
Still, the findings move us forward. Earlier genetic studies relied on intelligence measured in adults, which left open the possibility that poor health in middle age might be dragging down both test scores and lifespan. This study shows the genetic link exists even when intelligence is measured in childhood, a time when kids are typically healthy and their test scores reflect abilities that haven’t been affected by chronic disease. Yet those same genetic variants also predict longer lives for their parents. That points to a biological connection that starts early and lasts across generations.
Disclaimer: This article is for general informational purposes only and does not constitute medical, genetic, or professional advice. Consult qualified professionals for personalized guidance regarding health, genetics, or medical decisions.
Paper Summary
Methodology
Researchers used genome-wide association study (GWAS) data from two large samples. The childhood cognitive function data came from 12,441 individuals who completed intelligence tests during childhood. The longevity data included 389,166 individuals and measured combined parental attained age (how long both mothers and fathers lived). The team applied linkage disequilibrium score regression (LDSC) to estimate the genetic correlation between these two traits. This statistical method examines patterns of genetic variation across the genome to determine how much genetic overlap exists between different characteristics. The LDSC intercepts were close to 1 for both traits, indicating minimal inflation from population stratification.
Results
The analysis revealed a positive genetic correlation of rg = 0.35 (SE = 0.14, P = 0.01) between childhood cognitive function and parental longevity. Genetic variants associated with higher childhood cognitive test scores were also associated with parents living longer. The SNP-based heritability estimates showed that 27.3% (SE = 4.7) of variation in childhood cognitive function and 28.9% (SE = 0.7) of variation in parental longevity could be attributed to common genetic variants measured in the study.
Limitations
The study has several limitations. First, the genetic correlation represents an average shared effect across all autosomal genetic variants and does not identify which specific genomic regions or genes contribute to this relationship. Second, the analysis cannot distinguish between different models of pleiotropy (horizontal versus vertical) that might explain the genetic overlap. Third, the study excluded sex chromosomes, potentially missing genetic effects specific to those chromosomes. Finally, while the genetic correlation is consistent with shared genetic influences, it does not prove causation or reveal the biological mechanisms behind the association.
Funding and Disclosures
W. David Hill received support from a Career Development Award from the Medical Research Council (MRC) [MR/T030852/1] for the project titled “From genetic sequence to phenotypic consequence: genetic and environmental links between cognitive ability, socioeconomic position, and health.” Ian J. Deary received support from grants from the National Institutes of Health (NIH) (R01AG054628 and U01AG083829) and from BBSRC and ESRC (BB/W008793/1). The authors reported no conflicts of interest.
Publication Details
Hill, W. D., & Deary, I. J. (2025). Shared genetic etiology between childhood cognitive function and longevity. Genomic Psychiatry. doi:10.61373/gp025l.0098. Published online October 21, 2025. The article is licensed under the Creative Commons Attribution 4.0 International Public License (CC BY 4.0).








12K kids have 396K parents?