Sulfatid

Sulfatid
	; Hemijska struktura sulfatida
Identifikacija
3D model (Jmol)	interaktivna slika;
DrugBank	DB04780;
PubChem C ID	5459389;
	SMILES CCCCCCCCCCCCCCCCCCCCCC[C@@H](O)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](OS(O)(=O)=O)[C@H]1O)[C@H](O)\C=C\CCCCCCCCCCCCC; ; ; ; ; ;
Svojstva
Hemijska formula	C48H93NO12S
Molarna masa	908,317
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Sulfatidi su klasa sulfatisanih galaktozilceramida koji se prvenstveno sintetišu u oligodendrocitima u centralnom nervnom sistemu. Sulfatidi su tip sulfolipida.^[3]^[4]

Klinički značaj

Alteracije sulfatidnog metabolizma, razmena i homeostaza su prisutni u najranijim klinički prepoznatljivim stepenima Alchajmerove bolesti i vezani su za metahromatsku leukodistrofiju (MLD).

Osobine

Osobina	Vrednost
Broj akceptora vodonika	12
Broj donora vodonika	7
Broj rotacionih veza	43
Particioni koeficijent^[5] (ALogP)	12,3
Rastvorljivost^[6] (logS, log(mol/L))	-17,2
Polarna površina^[7] (PSA, Å²)	220,7

Vidi još

Sulfatidoza

Reference

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Michael A Lieberman; Ricer, Rick (2010). Lippincott's Illustrated Q&A Review of Biochemistry (1. Pap/Psc изд.). Lippincott Williams & Wilkins. ISBN 978-1-60547-302-4.
^ Huang JQ, Trasler JM, Igdoura S, Michaud J, Hanal N, Gravel RA (1997). „Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases”. Human Molecular Genetics. 6 (11): 1879—85. PMID 9302266. doi:10.1093/hmg/6.11.1879.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Michael A Lieberman; Ricer, Rick (2010). Lippincott's Illustrated Q&A Review of Biochemistry (1. Pap/Psc изд.). Lippincott Williams & Wilkins. ISBN 978-1-60547-302-4.

Spoljašnje veze

Sulfatides на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[3] Michael A Lieberman; Ricer, Rick (2010). Lippincott's Illustrated Q&A Review of Biochemistry (1. Pap/Psc изд.). Lippincott Williams & Wilkins. ISBN 978-1-60547-302-4.

[4] Huang JQ, Trasler JM, Igdoura S, Michaud J, Hanal N, Gravel RA (1997). „Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases”. Human Molecular Genetics. 6 (11): 1879—85. PMID 9302266. doi:10.1093/hmg/6.11.1879.

[5] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[6] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[7] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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