OGFr
| Receptor opioidnog faktora rasta | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | OGFR; | ||||||||||
| Vanjski ID | OMIM: 606459 MGI: 1919325 HomoloGene: 7199 GeneCards: OGFR Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 11054 | 72075 | |||||||||
| Ensembl | ENSG00000060491 | ENSMUSG00000049401 | |||||||||
| UniProt | Q9NZT2 | Q80UU6 | |||||||||
| RefSeq (mRNA) | NM_007346 | NM_031373 | |||||||||
| RefSeq (protein) | NP_031372 | NP_113550 | |||||||||
| Lokacija (UCSC) |
Chr 20: 60.91 - 60.92 Mb |
Chr 2: 180.52 - 180.53 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Receptor opioidnog faktora rasta, OGFr ili ζ-opioidni receptor, je protein koji je kod čoveka kodiran OGFR genom.[1][2] On je receptor opioidnog faktora rasta (OGF), takođe poznatog kao Met-enkefalin. To je endogeni ligand ovog receptora. OGFr je originalno bio otkriven i nazvan kao novi opioidni receptor zeta (ζ). Međutim naknadno je utvrđeno da on ima neznatnu homologiju sekvence sa drugim opioidnim receptorima, i da ima veoma različitu funkciju.
Funkcija
[уреди | уреди извор]Prirodna funkcija ovog receptora je regulacija rasta tkiva,[3][4][5][6] i bilo je pokazano da je važan u embrionskom razvoju,[7] zarastanju rana,[8] i za pojedine tipove raka.[9][10][11][12]
OGF je negativni regulator ćelijske proliferacije i organizacije tkiva u nizu procesa. Utvrđeno je da je nevezani receptor lokalizovan na spoljašnjosti jedra, gde on vezuje OGF i naknadno biva translociran u jedro. Kodirajuća sekvenca ovog gena sadrži polimorfni region sa 60 nukleotidnim tandemom nesavršenih ponavljajućih jedinica. Iranskripti koji sadrže između nula i osam ponavljajućih jedinica su nađeni.[1]
Terapeutske primena
[уреди | уреди извор]Povišeno izražavanje OGFr-a i konsekventna stimulacija OGF-OGFr sistema su važni za antiproliferativne efekte imidazohinolinskih lekova kao što su imikuimod i rezikuimod, koji su modifikatori imunskog sistema sa potentnim antivirusnim i antitumorskim dejstvom. Oni se koriste kao topikalni kremovi za lečenje raka kože i bradavica.[13]
Literatura
[уреди | уреди извор]- ^ а б „Entrez Gene: OGFR opioid growth factor receptor”.
- ^ Zagon IS, Verderame MF, Allen SS, McLaughlin PJ (2000). . „Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans”. Brain Res.. 856 (1-2): 75—83. PMID 10677613. doi:10.1016/S0006-8993(99)02330-6.
- ^ Wu Y, McLaughlin PJ, Zagon IS (1998). . „Ontogeny of the opioid growth factor, Met5-enkephalin, preproenkephalin gene expression, and the zeta opioid receptor in the developing and adult aorta of rat”. Dev. Dyn.. 211 (4): 327—37. PMID 9566952. doi:10.1002/(SICI)1097-0177(199804)211:4<327::AID-AJA4>3.0.CO;2-J.
- ^ Zagon IS, Verderame MF, McLaughlin PJ (2002). . „The biology of the opioid growth factor receptor (OGFr)”. Brain Research. Brain Research Reviews. 38 (3): 351—76. PMID 11890982. doi:10.1016/S0165-0173(01)00160-6.
- ^ Malendowicz LK, Rebuffat P, Tortorella C, Nussdorfer GG, Ziolkowska A, Hochol A (2005). . „Effects of met-enkephalin on cell proliferation in different models of adrenocortical-cell growth”. Int. J. Mol. Med.. 15 (5): 841—5. PMID 15806307.
- ^ Cheng F, McLaughlin PJ, Verderame MF, Zagon IS (2009). . „The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferation”. Molecular Biology of the Cell. 20 (1): 319—27. PMC 2613082
. PMID 18923142. doi:10.1091/mbc.E08-07-0681.
- ^ Zagon IS, Wu Y, McLaughlin PJ (1999). . „Opioid growth factor and organ development in rat and human embryos”. Brain Res.. 839 (2): 313—22. PMID 10519055. doi:10.1016/S0006-8993(99)01753-9.
- ^ Sassani JW, Zagon IS, McLaughlin PJ (2003). . „Opioid growth factor modulation of corneal epithelium: uppers and downers”. Curr. Eye Res.. 26 (5): 249—62. PMID 12854052. doi:10.1076/ceyr.26.4.249.15427.
- ^ Zagon IS, Smith JP, McLaughlin PJ (1999). . „Human pancreatic cancer cell proliferation in tissue culture is tonically inhibited by opioid growth factor”. Int. J. Oncol.. 14 (3): 577—84. PMID 10024694.
- ^ McLaughlin PJ, Levin RJ, Zagon IS (1999). . „Regulation of human head and neck squamous cell carcinoma growth in tissue culture by opioid growth factor”. Int. J. Oncol.. 14 (5): 991—8. PMID 10200353.
- ^ Cheng F, Zagon IS, Verderame MF, McLaughlin PJ (2007). . „The opioid growth factor (OGF)-OGF receptor axis uses the p16 pathway to inhibit head and neck cancer”. Cancer Research. 67 (21): 10511—8. PMID 17974995. doi:10.1158/0008-5472.CAN-07-1922.
- ^ Donahue RN, McLaughlin PJ, Zagon IS (2009). . „Cell Proliferation of Human Ovarian Cancer is Regulated by the Opioid Growth Factor - Opioid Growth Factor Receptor Axis”. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 296 (6): R1716—25. PMID 19297547. doi:10.1152/ajpregu.00075.2009.
- ^ Zagon IS, Donahue RN, Rogosnitzky M, McLaughlin PJ (2008). . „Imiquimod upregulates the opioid growth factor receptor to inhibit cell proliferation independent of immune function”. Experimental Biology and Medicine (Maywood, N.J.). 233 (8): 968—79. PMID 18480416. doi:10.3181/0802-RM-58.
Dodatna literatura
[уреди | уреди извор]- Zagon IS, Verderame MF, McLaughlin PJ (2002). . „The biology of the opioid growth factor receptor (OGFr).”. Brain Res. Brain Res. Rev.. 38 (3): 351—76. PMID 11890982. doi:10.1016/S0165-0173(01)00160-6.
- Zagon IS, Verderame MF, Allen SS, McLaughlin PJ (2000). . „Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans.”. Brain Res.. 856 (1-2): 75—83. PMID 10677613. doi:10.1016/S0006-8993(99)02330-6.
- Wu CJ; Yang XF; McLaughlin S; et al. (2000). . „Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia.”. J. Clin. Invest.. 106 (5): 705—14. PMC 381287 . PMID 10974024. doi:10.1172/JCI10196.
- Hattori A; Okumura K; Nagase T; et al. (2001). . „Characterization of long cDNA clones from human adult spleen.”. DNA Res.. 7 (6): 357—66. PMID 11214971. doi:10.1093/dnares/7.6.357.
- Deloukas P; Matthews LH; Ashurst J; et al. (2002). . „The DNA sequence and comparative analysis of human chromosome 20.”. Nature. 414 (6866): 865—71. PMID 11780052. doi:10.1038/414865a.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). . „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Zagon IS; Ruth TB; Leure-duPree AE; et al. (2003). . „Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea.”. Brain Res.. 967 (1-2): 37—47. PMID 12650964. doi:10.1016/S0006-8993(02)04172-0.
- Ota T; Suzuki Y; Nishikawa T; et al. (2004). . „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet.. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). . „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res.. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- McLaughlin PJ, Zagon IS (2006). . „Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor.”. Int. J. Oncol.. 28 (6): 1577—83. PMID 16685459.
- Zagon IS, McLaughlin PJ (2006). . „Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers.”. Int. J. Oncol.. 29 (2): 489—94. PMID 16820893.
- Olsen JV; Blagoev B; Gnad F; et al. (2006). . „Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”. Cell. 127 (3): 635—48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.
- McLaughlin PJ, Verderame MF, Hankins JL, Zagon IS (2007). . „Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neck.”. Int. J. Mol. Med.. 19 (3): 421—8. PMID 17273790.
