Metilnaltrekson

Metilnaltrekson
Klinički podaci
Drugs.com	Monografija
Način primene	Subkutano
Farmakokinetički podaci
Poluvreme eliminacije	8,89 ± 2,59 h
Izlučivanje	Renalno
Identifikatori
CAS broj	73232-52-7
ATC kod	A06AH01 (WHO)
PubChem	CID 5361918
DrugBank	DB06800
ChemSpider	4514884
ChEMBL	CHEMBL1186579
Hemijski podaci
Formula	C21H26NO4
Molarna masa	356,435
	SMILES [H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CC[N+](C)(CC3CC3)[C@]([H])(C4)[C@]1(O)CCC2=O; ;
	InChI InChI=1S/C21H25NO4/c1-22(11-12-2-3-12)9-8-20-17-13-4-5-14(23)18(17)26-19(20)15(24)6-7-21(20,25)16(22)10-13/h4-5,12,16,19,25H,2-3,6-11H2,1H3/p+1/t16-,19+,20+,21-,22?/m1/s1 ; Key:JVLBPIPGETUEET-GAAHOAFPSA-O ;

Metilnaltrekson je organsko jedinjenje, koje sadrži 21 atom ugljenika i ima molekulsku masu od 356,435 Da.^[1]^[2]^[3]^[4]^[5]^[6]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	4
Broj donora vodonika	2
Broj rotacionih veza	2
Particioni koeficijent^[7] (ALogP)	0,3
Rastvorljivost^[8] (logS, log(mol/L))	-4,1
Polarna površina^[9] (PSA, Å²)	66,8

Reference

^ Thomas J: Opioid-induced bowel dysfunction. Thomas, J. (јануар 2008). . „Opioid-induced bowel dysfunction”. J Pain Symptom Manage. 35 (1): 103—13. PMID 17981003. doi:10.1016/j.jpainsymman.2007.01.017. . Epub 2007 Nov 5. PMID 17981003
^ Rotshteyn, Yakov; Boyd, Thomas A.; Yuan, Chun-Su (фебруар 2011). . „Methylnaltrexone bromide: Research update of pharmacokinetics following parenteral administration”. Expert Opinion on Drug Metabolism & Toxicology. 7 (2): 227—235. PMID 21222554. doi:10.1517/17425255.2011.549824.
^ Chandrasekaran A, Tong Z, Li H, Erve JC, DeMaio W, Goljer I, McConnell O, Rotshteyn Y, Hultin T, Talaat R, Scatina J: Metabolism of intravenous methylnaltrexone in mice, rats, dogs, and humans. Chandrasekaran, Appavu; Tong, Zeen; Li, Hongshan; Erve, John C.L.; Demaio, William; Goljer, Igor; McConnell, Oliver; Rotshteyn, Yakov; Hultin, Theresa; Talaat, Rasmy; Scatina, Joann (април 2010). . „Metabolism of Intravenous Methylnaltrexone in Mice, Rats, Dogs, and Humans”. Drug Metabolism and Disposition. 38 (4): 606—616. PMID 20053817. doi:10.1124/dmd.109.031179. .. Epub 2010 Jan 6. PMID 20053817
^ Bader S, Jaroslawski K, Blum HE, Becker G: Opioid-induced constipation in advanced illness: safety and efficacy of methylnaltrexone bromide. Bader, S.; Jaroslawski, K.; Blum, H. E.; Becker, G. (2011). . „Opioid-induced constipation in advanced illness: Safety and efficacy of methylnaltrexone bromide”. Clinical Medicine Insights: Oncology. 5: 201—11. PMC 3153119 . PMID 21836816. doi:10.4137/CMO. . S4867. Epub 2011 Jul 14. PMID 21836816
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ . . doi:10.1021/jp980230o. Недостаје или је празан параметар |title= (помоћ)
^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). . „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, P.; Rohde, B.; Selzer, P. (2000). . „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Methylnaltrexone

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Thomas J: Opioid-induced bowel dysfunction. Thomas, J. (јануар 2008). . „Opioid-induced bowel dysfunction”. J Pain Symptom Manage. 35 (1): 103—13. PMID 17981003. doi:10.1016/j.jpainsymman.2007.01.017. . Epub 2007 Nov 5. PMID 17981003

[2] Rotshteyn, Yakov; Boyd, Thomas A.; Yuan, Chun-Su (фебруар 2011). . „Methylnaltrexone bromide: Research update of pharmacokinetics following parenteral administration”. Expert Opinion on Drug Metabolism & Toxicology. 7 (2): 227—235. PMID 21222554. doi:10.1517/17425255.2011.549824.

[3] Chandrasekaran A, Tong Z, Li H, Erve JC, DeMaio W, Goljer I, McConnell O, Rotshteyn Y, Hultin T, Talaat R, Scatina J: Metabolism of intravenous methylnaltrexone in mice, rats, dogs, and humans. Chandrasekaran, Appavu; Tong, Zeen; Li, Hongshan; Erve, John C.L.; Demaio, William; Goljer, Igor; McConnell, Oliver; Rotshteyn, Yakov; Hultin, Theresa; Talaat, Rasmy; Scatina, Joann (април 2010). . „Metabolism of Intravenous Methylnaltrexone in Mice, Rats, Dogs, and Humans”. Drug Metabolism and Disposition. 38 (4): 606—616. PMID 20053817. doi:10.1124/dmd.109.031179. .. Epub 2010 Jan 6. PMID 20053817

[4] Bader S, Jaroslawski K, Blum HE, Becker G: Opioid-induced constipation in advanced illness: safety and efficacy of methylnaltrexone bromide. Bader, S.; Jaroslawski, K.; Blum, H. E.; Becker, G. (2011). . „Opioid-induced constipation in advanced illness: Safety and efficacy of methylnaltrexone bromide”. Clinical Medicine Insights: Oncology. 5: 201—11. PMC 3153119 . PMID 21836816. doi:10.4137/CMO. . S4867. Epub 2011 Jul 14. PMID 21836816

[5] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[6] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[7] . . doi:10.1021/jp980230o. Недостаје или је празан параметар |title= (помоћ)

[8] Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). . „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[9] Ertl, P.; Rohde, B.; Selzer, P. (2000). . „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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