HAS2

HAS2
Identifikatori
Alijasi	HAS2
Spoljašnji ID	OMIM: 601636 MGI: 107821 HomoloGene: 3892 GeneCards: HAS2
Genska lokacija (miš) Hr. Chromosome 15 (mouse) Band 15 D1|15 23.31 cM Start 56,529,023 bp Kraj 56,557,935 bp
Obrazac RNK izražavanja More reference expression data
Genska ontologija Molecular function • transferase activity • glycosyltransferase activity • hyaluronan synthase activity • GO:0001948, GO:0016582 везивање за протеине плазме • identical protein binding Cellular component • цитоплазма • саставни део мембране • мембрана • integral component of plasma membrane • plasma membrane raft Biological process • atrioventricular canal development • positive regulation of keratinocyte proliferation • hyaluronan biosynthetic process • positive regulation of urine volume • развој бубрега • estrous cycle • positive regulation of cell migration • cellular response to tumor necrosis factor • bone morphogenesis • cellular response to platelet-derived growth factor stimulus • cellular response to fluid shear stress • Васкулогенеза • positive regulation of smooth muscle cell migration • positive regulation of keratinocyte migration • positive regulation of substrate adhesion-dependent cell spreading • positive regulation of hyaluronan biosynthetic process • extracellular matrix assembly • cellular response to interleukin-1 • positive regulation of cell population proliferation • extracellular polysaccharide biosynthetic process • hyaluronan metabolic process • endocardial cushion to mesenchymal transition • renal water absorption • positive regulation of monocyte aggregation • regulation of extracellular matrix assembly Sources:Amigo / QuickGO
Ortolozi
Vrste	Čovek	Miš
Entrez	3037	15117
Ensembl	ENSG00000170961	ENSMUSG00000022367
UniProt	Q92819	P70312
RefSeq (mRNA)	NM_005328	NM_008216
RefSeq (protein)	NP_005319	NP_032242
Location (UCSC)	n/a	Chr 15: 56.53 – 56.56 Mb
PubMed search
Wikidata
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Hijaluronanska sintaza 2 je enzim koji je kod ljudi kodiran genom HAS2.

Literatura

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• Simpson MA, Wilson CM, Furcht LT, et al. (2002). . „Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells”. J. Biol. Chem.. 277 (12): 10050—7. PMID 11790779. doi:10.1074/jbc.M110069200 . 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). . „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 . 
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• Sussmann M, Sarbia M, Meyer-Kirchrath J, et al. (2004). . „Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins”. Circ. Res.. 94 (5): 592—600. PMID 14752026. doi:10.1161/01.RES.0000119169.87429.A0 . 
• Monslow J, Williams JD, Guy CA, et al. (2004). . „Identification and analysis of the promoter region of the human hyaluronan synthase 2 gene”. J. Biol. Chem.. 279 (20): 20576—81. PMID 14988410. doi:10.1074/jbc.M312666200 . 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). . „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res.. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504. 
• Morerio C, Rapella A, Rosanda C, et al. (2005). . „PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement”. Cancer Genet. Cytogenet.. 156 (2): 183—4. PMID 15642402. doi:10.1016/j.cancergencyto.2004.04.017. 
• Ducale AE, Ward SI, Dechert T, Yager DR (2005). . „Regulation of hyaluronan synthase-2 expression in human intestinal mesenchymal cells: mechanisms of interleukin-1beta-mediated induction”. Am. J. Physiol. Gastrointest. Liver Physiol.. 289 (3): G462—70. PMID 15677552. doi:10.1152/ajpgi.00494.2004. 
• Saavalainen K, Pasonen-Seppänen S, Dunlop TW, et al. (2005). . „The human hyaluronan synthase 2 gene is a primary retinoic acid and epidermal growth factor responding gene”. J. Biol. Chem.. 280 (15): 14636—44. PMID 15722343. doi:10.1074/jbc.M500206200 . 
• Chao H, Spicer AP (2005). . „Natural antisense mRNAs to hyaluronan synthase 2 inhibit hyaluronan biosynthesis and cell proliferation”. J. Biol. Chem.. 280 (30): 27513—22. PMID 15843373. doi:10.1074/jbc.M411544200 . 
• Nishida Y, Knudson W, Knudson CB, Ishiguro N (2005). . „Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity”. Exp. Cell Res.. 307 (1): 194—203. PMC 3182490 . PMID 15922739. doi:10.1016/j.yexcr.2005.03.026. 
• Grskovic B, Pollaschek C, Mueller MM, Stuhlmeier KM (2006). . „Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells”. Biochim. Biophys. Acta. 1760 (6): 890—5. PMID 16564133. doi:10.1016/j.bbagen.2006.02.002. 
• Monslow J, Williams JD, Fraser DJ, et al. (2006). . „Sp1 and Sp3 mediate constitutive transcription of the human hyaluronan synthase 2 gene”. J. Biol. Chem.. 281 (26): 18043—50. PMID 16603733. doi:10.1074/jbc.M510467200 . 
• Selbi W, Day AJ, Rugg MS, et al. (2007). . „Overexpression of hyaluronan synthase 2 alters hyaluronan distribution and function in proximal tubular epithelial cells”. J. Am. Soc. Nephrol.. 17 (6): 1553—67. PMID 16687630. doi:10.1681/ASN.2005080879 . 
• Campo GM, Avenoso A, Campo S, et al. (2007). . „TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate”. Mol. Cell. Biochem.. 292 (1–2): 169—78. PMID 16786194. S2CID 37598580. doi:10.1007/s11010-006-9230-7. 
• Cook AC, Chambers AF, Turley EA, Tuck AB (2006). . „Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy”. J. Biol. Chem.. 281 (34): 24381—9. PMID 16807238. doi:10.1074/jbc.M602694200 . 
• Klewer SE, Yatskievych T, Pogreba K, Stevens MV, Antin PB, Camenisch TD (2006). . „Has2 expression in heart forming regions is independent of BMP signaling”. Gene Expr Patterns. 6 (5): 462—70. PMID 16458617. doi:10.1016/j.modgep.2005.11.005. 
• Camenisch TD, Schroeder JA, Bradley J, Klewer SE, McDonald JA (2002). . „Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors”. Nat. Med.. 8 (8): 850—5. PMID 12134143. S2CID 6092884. doi:10.1038/nm742. 
• Camenisch TD, Spicer AP, Brehm-Gibson T, Biesterfeldt J, Augustine ML, Calabro A Jr, Kubalak S, Klewer SE, McDonald JA (2000). . „Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme”. J Clin Invest. 106 (3): 349—60. PMC 314332 . PMID 10930438. doi:10.1172/JCI10272.