Fosfenitoin

Fosfenitoin
Klinički podaci
Prodajno ime	Cerebyx, Prodilantin
Drugs.com	Monografija
Način primene	Intravenozno
Farmakokinetički podaci
Poluvreme eliminacije	15 minuta
Izlučivanje	Renalno
Identifikatori
CAS broj	93390-81-9
ATC kod	N03AB05 (WHO)
PubChem	CID 56339
DrugBank	DB01320
ChemSpider	50839
KEGG	C07840
ChEMBL	CHEMBL919
Hemijski podaci
Formula	C16H15N2O6P
Molarna masa	362,274
	SMILES OP(O)(=O)OCN1C(=O)NC(C1=O)(C1=CC=CC=C1)C1=CC=CC=C1; ;
	InChI InChI=1S/C16H15N2O6P/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23/h1-10H,11H2,(H,17,20)(H2,21,22,23) ; Key:XWLUWCNOOVRFPX-UHFFFAOYSA-N ;

Fosfenitoin je organsko jedinjenje, koje sadrži 16 atoma ugljenika i ima molekulsku masu od 362,274 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	6
Broj donora vodonika	3
Broj rotacionih veza	5
Particioni koeficijent^[8] (ALogP)	1,7
Rastvorljivost^[9] (logS, log(mol/L))	-2,7
Polarna površina^[10] (PSA, Å²)	126,0

Reference

^ Johnson J, Wrenn K. Johnson, Jeffrey; Wrenn, Keith (2001 Jul). . „Inappropriate fosphenytoin use in the ED”. Am J Emerg Med. 19 (4): 293—4. PMID 11447516. doi:10.1053/ajem.2001.24471. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Applebaum J, Levine J, Belmaker RH. Applebaum, Julia; Levine, Joseph; Belmaker, R. H. (2003 Apr). . „Intravenous fosphenytoin in acute mania”. J Clin Psychiatry. 64 (4): 408—9. PMID 12716241. doi:10.4088/JCP.v64n0408. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ McCleane GJ. McCleane, Gary J. (2002 Apr). . „Intravenous infusion of fosphenytoin produces prolonged pain relief: a case report”. J Pain. 3 (2): 156—8. PMID 14622802. doi:10.1054/jpai.2002.123004. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Browne TR, Kugler AR, Eldon MA: Pharmacology and pharmacokinetics of fosphenytoin. Neurology. 1996 Jun;46(6 Suppl 1):S3-7. PMID 8649612 8649612
^ Luszczki JJ: Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions. Pharmacol Rep. 2009 Mar-Apr;. . 61 (2): 197—216. PMID 19443931. Недостаје или је празан параметар |title= (помоћ)
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). . „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). . „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Fosphenytoin

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Johnson J, Wrenn K. Johnson, Jeffrey; Wrenn, Keith (2001 Jul). . „Inappropriate fosphenytoin use in the ED”. Am J Emerg Med. 19 (4): 293—4. PMID 11447516. doi:10.1053/ajem.2001.24471. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[2] Applebaum J, Levine J, Belmaker RH. Applebaum, Julia; Levine, Joseph; Belmaker, R. H. (2003 Apr). . „Intravenous fosphenytoin in acute mania”. J Clin Psychiatry. 64 (4): 408—9. PMID 12716241. doi:10.4088/JCP.v64n0408. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[3] McCleane GJ. McCleane, Gary J. (2002 Apr). . „Intravenous infusion of fosphenytoin produces prolonged pain relief: a case report”. J Pain. 3 (2): 156—8. PMID 14622802. doi:10.1054/jpai.2002.123004. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[4] Browne TR, Kugler AR, Eldon MA: Pharmacology and pharmacokinetics of fosphenytoin. Neurology. 1996 Jun;46(6 Suppl 1):S3-7. PMID 8649612 8649612

[5] Luszczki JJ: Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions. Pharmacol Rep. 2009 Mar-Apr;. . 61 (2): 197—216. PMID 19443931. Недостаје или је празан параметар |title= (помоћ)

[6] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[7] Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[8] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[9] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). . „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[10] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). . „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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