FUT8

FUT8
Available structures PDB Pretraga ortologa: PDBe RCSB List of PDB id codes 2DE0
Identifikatori
Alijasi	FUT8
Spoljašnji ID	OMIM: 602589 MGI: 1858901 HomoloGene: 9650 GeneCards: FUT8
Genska lokacija (miš) Hr. Chromosome 12 (mouse) Band 12|12 C3 Start 77,284,899 bp Kraj 77,523,112 bp
Obrazac RNK izražavanja More reference expression data
Genska ontologija Molecular function • transferase activity • glycosyltransferase activity • SH3 domain binding • glycoprotein 6-alpha-L-fucosyltransferase activity • alpha-(1->6)-fucosyltransferase activity Cellular component • саставни део мембране • Голџијев апарат • мембрана • Golgi membrane • Golgi cisterna membrane • extracellular exosome • цитосол Biological process • GDP-L-fucose metabolic process • regulation of cellular response to oxidative stress • N-glycan fucosylation • N-glycan processing • in utero embryonic development • respiratory gaseous exchange by respiratory system • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation • oligosaccharide biosynthetic process • Regulacija genske ekspresije • integrin-mediated signaling pathway • protein N-linked glycosylation • transforming growth factor beta receptor signaling pathway • cell migration • L-fucose catabolic process • receptor metabolic process • protein N-linked glycosylation via asparagine Sources:Amigo / QuickGO
Ortolozi
Vrste	Čovek	Miš
Entrez	2530	53618
Ensembl	ENSG00000033170	ENSMUSG00000021065
UniProt	Q9BYC5	Q9WTS2
RefSeq (mRNA)	NM_004480 NM_178154 NM_178155 NM_178156 NM_178157 NM_001371533 NM_001371534 NM_001371536	NM_001252614 NM_001252615 NM_001252616 NM_016893
RefSeq (protein)	NP_004471 NP_835368 NP_835369 NP_001358462 NP_001358463 NP_001358465	NP_001239543 NP_001239544 NP_001239545 NP_058589
Location (UCSC)	n/a	Chr 12: 77.28 – 77.52 Mb
PubMed search
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Alfa-(1,6)-fukoziltransferaza je enzim koji je kod ljudi kodiran genom FUT8.

Ovaj enzim pripada porodici fukoziltransferaza. Proizvod ovog gena katalizuje transfer fukoze sa GDP-fukoze na kompleksne glikopeptide N-vezanog tipa. Ovaj enzim se razlikuje od drugih fukoziltransferaza koje katalizuju dodavanje alfa1-2, alfa1-3 i alfa1-4 fukoze. Izražavanje ovog gena može doprineti malignitetu ćelija raka i njihovim invazivnim i metastatskim sposobnostima. Identifikovane su alternativno spojene varijante koje kodiraju različite izoforme.

„Potelligent“ platforma kompanije Kyowa Hakko Kirin koristi CHO ćelijsku liniju u kojoj je FUT8 izbačen da bi se napravila afukozilovana monoklonska antitela.

Literatura

• Miyoshi E, Noda K, Yamaguchi Y, et al. (2000). . „The alpha1-6-fucosyltransferase gene and its biological significance.”. Biochim. Biophys. Acta. 1473 (1): 9—20. PMID 10580126. doi:10.1016/s0304-4165(99)00166-x. 
• Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). . „Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.”. AIDS Res. Hum. Retroviruses. 6 (3): 371—80. PMID 2187500. doi:10.1089/aid.1990.6.371. 
• Pal R, Hoke GM, Sarngadharan MG (1989). . „Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.”. Proc. Natl. Acad. Sci. U.S.A.. 86 (9): 3384—8. Bibcode:1989PNAS...86.3384P. PMC 287137 . PMID 2541446. doi:10.1073/pnas.86.9.3384 . 
• Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). . „Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.”. J. Virol.. 63 (6): 2452—6. PMC 250699 . PMID 2542563. doi:10.1128/jvi.63.6.2452-2456.1989. 
• Kozarsky K, Penman M, Basiripour L, et al. (1989). . „Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein.”. J. Acquir. Immune Defic. Syndr.. 2 (2): 163—9. PMID 2649653. 
• Robinson WE, Montefiori DC, Mitchell WM (1988). . „Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.”. AIDS Res. Hum. Retroviruses. 3 (3): 265—82. PMID 2829950. doi:10.1089/aid.1987.3.265. 
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). . „A "double adaptor" method for improved shotgun library construction.”. Anal. Biochem.. 236 (1): 107—13. PMID 8619474. doi:10.1006/abio.1996.0138. 
• Yu W, Andersson B, Worley KC, et al. (1997). . „Large-scale concatenation cDNA sequencing.”. Genome Res.. 7 (4): 353—8. PMC 139146 . PMID 9110174. doi:10.1101/gr.7.4.353. 
• Yanagidani S, Uozumi N, Ihara Y, et al. (1997). . „Purification and cDNA cloning of GDP-L-Fuc:N-acetyl-beta-D-glucosaminide:alpha1-6 fucosyltransferase (alpha1-6 FucT) from human gastric cancer MKN45 cells.”. J. Biochem.. 121 (3): 626—32. PMID 9133635. doi:10.1093/oxfordjournals.jbchem.a021631. 
• Yamaguchi Y, Fujii J, Inoue S, et al. (1999). . „Mapping of the alpha-1,6-fucosyltransferase gene, FUT8, to human chromosome 14q24.3.”. Cytogenet. Cell Genet.. 84 (1–2): 58—60. PMID 10343104. S2CID 85305954. doi:10.1159/000015215. 
• Takahashi T, Ikeda Y, Tateishi A, et al. (2000). . „A sequence motif involved in the donor substrate binding by alpha1,6-fucosyltransferase: the role of the conserved arginine residues.”. Glycobiology. 10 (5): 503—10. PMID 10764839. doi:10.1093/glycob/10.5.503 . 
• Yamaguchi Y, Ikeda Y, Takahashi T, et al. (2000). . „Genomic structure and promoter analysis of the human alpha1, 6-fucosyltransferase gene (FUT8).”. Glycobiology. 10 (6): 637—43. PMID 10814706. doi:10.1093/glycob/10.6.637 . 
• Takahashi T, Ikeda Y, Miyoshi E, et al. (2000). . „alpha1,6fucosyltransferase is highly and specifically expressed in human ovarian serous adenocarcinomas.”. Int. J. Cancer. 88 (6): 914—9. PMID 11093814. S2CID 22110674. doi:10.1002/1097-0215(20001215)88:6<914::AID-IJC12>3.0.CO;2-1. 
• Roos C, Kolmer M, Mattila P, Renkonen R (2002). . „Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism.”. J. Biol. Chem.. 277 (5): 3168—75. PMID 11698403. doi:10.1074/jbc.M107927200 . 
• Coullin P, Crooijmans RP, Groenen MA, et al. (2003). . „Assignment of FUT8 to chicken chromosome band 5q1.4 and to human chromosome 14q23.2→q24.1 by in situ hybridization. Conserved and compared synteny between human and chicken.”. Cytogenet. Genome Res.. 97 (3–4): 234—8. PMID 12438718. S2CID 27532607. doi:10.1159/000066611. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). . „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 . 
• Martinez-Duncker I, Michalski JC, Bauvy C, et al. (2004). . „Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.”. Glycobiology. 14 (1): 13—25. PMID 14514715. doi:10.1093/glycob/cwh006 . 
• Ito Y, Miyauchi A, Yoshida H, et al. (2003). . „Expression of alpha1,6-fucosyltransferase (FUT8) in papillary carcinoma of the thyroid: its linkage to biological aggressiveness and anaplastic transformation.”. Cancer Lett.. 200 (2): 167—72. PMID 14568171. doi:10.1016/S0304-3835(03)00383-5. 

Spoljašnje veze

• Overview of all the structural information available in the PDB for UniProt: Q9BYC5 (Human FUT8) at the PDBe-KB.