Donepezil
 | |
| Klinički podaci | |
|---|---|
| Prodajno ime | Aricept, Aricept ODT, Eranz |
| Drugs.com | Monografija |
| Način primene | Oralno |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 70 h |
| Izlučivanje | Renalno |
| Identifikatori | |
| CAS broj | 120014-06-4  |
| ATC kod | N06DA02 (WHO) |
| PubChem | CID 3152 |
| DrugBank | DB00843 |
| ChemSpider | 3040 |
| ChEBI | CHEBI:53289 |
| ChEMBL | CHEMBL502 |
| Hemijski podaci | |
| Formula | C24H29NO3 |
| Molarna masa | 379,492 |
| |
| |
| Fizički podaci | |
| Tačka topljenja | 20.672 °C (37.242 °F) |
Donepezil je organsko jedinjenje, koje sadrži 24 atoma ugljenika i ima molekulsku masu od 379,492 Da.[1][2][3][4][5]
Osobine
[уреди | уреди извор]| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 4 |
| Broj donora vodonika | 0 |
| Broj rotacionih veza | 6 |
| Particioni koeficijent[6] (ALogP) | 4,6 |
| Rastvorljivost[7] (logS, log(mol/L)) | -5,8 |
| Polarna površina[8] (PSA, Å2) | 38,8 |
Reference
[уреди | уреди извор]- ^ Xiong, G.; Doraiswamy, P. M. (2005). „Combination drug therapy for Alzheimer's disease: What is evidence-based, and what is not?”. Geriatrics. 60 (6): 22—6. PMID 15948662.
- ^ Yesavage, J. A.; Mumenthaler, M. S.; Taylor, J. L.; Friedman, L.; O'Hara, R.; Sheikh, J.; Tinklenberg, J.; Whitehouse, P. J. (2002). „Donepezil and flight simulator performance: Effects on retention of complex skills”. Neurology. 59 (1): 123—5. PMID 12105320. S2CID 964825. doi:10.1212/wnl.59.1.123.
- ^ Sugimoto, H. (2001). „Donepezil hydrochloride: A treatment drug for Alzheimer's disease”. Chemical Record (New York, N.Y.). 1 (1): 63—73. PMID 11893059. doi:10.1002/1528-0691(2001)1:1<63::AID-TCR9>3.0.CO;2-J.
- ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
- ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
- ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
[уреди | уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
[уреди | уреди извор]
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
