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Case Reports
. 1994 Jul;241(8):511-6.
doi: 10.1007/BF00919714.

Multiple sclerosis and mitochondrial myopathy: an unusual combination of diseases

L Bet  1 , M Moggio, G P Comi, C Mariani, A Prelle, N Checcarelli, A Bordoni, N Bresolin, E Scarpini, G Scarlato
Affiliations
Case Reports

Multiple sclerosis and mitochondrial myopathy: an unusual combination of diseases

L Bet et al. J Neurol. 1994 Jul.

Abstract

A woman with definite multiple sclerosis (MS) and mitochondrial myopathy is described. There were widespread white matter lesions on magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) abnormalities and evoked response changes. Muscle biopsy showed ragged red fibres (RRFs) and cytochrome c oxidase (CoX) deficiency. Southern blot analysis revealed a large deletion of mitochondrial DNA (mtDNA). The patient may be affected by two unrelated diseases, MS and mitochondrial myopathy, but this combination has never previously been reported.

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References

    1. Nature. 1981 Apr 9;290(5806):457-65 - PubMed
    1. J Neurol Sci. 1993 Jul;117(1-2):24-7 - PubMed
    1. Neurology. 1979 May;29(5):717-20 - PubMed
    1. Lancet. 1989 Apr 22;1(8643):902-3 - PubMed
    1. Science. 1988 Dec 9;242(4884):1427-30 - PubMed

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