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Comparative Study
. 1980;13(2):177-80.
doi: 10.1002/jso.2930130213.

Association between estrogen receptors and weight in women with breast cancer

A E Papatestas, D Panveliwalla, D Pertsemlidis, M Mulvihill, A H Aufses Jr
Comparative Study

Association between estrogen receptors and weight in women with breast cancer

A E Papatestas et al. J Surg Oncol. 1980.

Abstract

A significant association between body weight and estrogen receptor protein (ERP) was noted in 83 women with primary and metastatic breast cancer. Thirteen of 34 (54%) women with weight greater than 150 lb had low or absent receptor protein (less than 10 femtomoles/mg of cytoplasmic protein) compared to 15 of 59 (25%) women with weight less than 150 lb (P less than 0.025). The observed association was stronger in the group of 62 postmenopausal women (P less than 0.01). The findings suggest that the endocrine and metabolic milieu in women with increased weight favors autonomous growth of breast cancer, and adjuvant treatment in this group should be planned accordingly.

PIP: Body weight, as a parameter to be considered in the treatment of women with breast cancer, was studied to determine any association between it and estrogen receptor protein (ERP) content. ERP was determined in 83 women with primary or metastatic breast tumors. A strong association between ERP and body weight was noted among the 62 postmenopausal women with primary and metastatic tumors. 80% of those with weight equal to or less than 150 pounds had positive ERs, as opposed to only 43% of those of higher weight (P .01). A similar assocation was found among the 56 postmenopausal women with primary breast tumors. The corresponding percentages were 81 and 47 (P .01). There were 21 determinations of ERP among premenopausal women: 13 of 21 (61%) had positive ER as opposed to 42 of 62 (68%) in the postmenopausal group. In all 83 women combined, 11 of 24 overweight women had positive ERP determinations compared with 44 of 59 (75%) with lower weight (P .025).

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