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Observational Study
. 2024 Feb 16;22(1):165.
doi: 10.1186/s12967-024-04969-3.

Association between dietary vitamin B1 intake and cognitive function among older adults: a cross-sectional study

Weiai Jia #  1 , Hemei Wang #  1 , Chao Li  1 , Jingpu Shi  1 , Fangfang Yong  1 , Huiqun Jia  2
Affiliations
Observational Study

Association between dietary vitamin B1 intake and cognitive function among older adults: a cross-sectional study

Weiai Jia et al. J Transl Med. .

Abstract

Background: This study aims to investigate the relationship between vitamin B1 intake and cognitive function in older adults.

Methods: This cross-sectional observational study utilized data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. A total of 2422 participants were included in the analysis, with dietary vitamin B1 intake being determined by averaging two 24-h dietary recalls. Cognitive function was assessed using three cognitive function tests: the Digit Symbol Substitution Test (DSST) for processing speed, the Animal Fluency Test (AFT) for executive function, a Consortium to Establish a Registry for Alzheimer's disease (CERAD) subtest for memory. Test-specific and global cognition z score was created. Multivariate linear regression models were used to explore the association between vitamin B1 and cognitive function.

Results: 2422 participants, aged 60 years and older, were included from NHANES across two survey cycles (2011-2014). Higher vitamin B1 intake was associated with higher DSST, AFT scores (P < 0.001) as well as the global cognition z score (P = 0.008). In the fully adjusted model, as compared to the lowest quartile (Q1), the highest quartile (Q4) of vitamin B1 intake was related to higher DSST score (β = 2.23, 95% CI 0.79 ~ 3.67) and global cognition z sore (β = 0.09, 95% CI 0.02 ~ 0.16). The association between dietary vitamin B1 intake and cognitive function scores in US adults is linear. There was no detected significant statistical interaction between these variables.

Conclusions: Increased dietary intake of vitamin B1 was associated with better cognitive function in individuals aged over 60.

Keywords: Cognitive function; Cross-sectional study; NHANES; Vitamin B1 intake.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart detailing the selection process for patients included in this retrospective analysis
Fig. 2
Fig. 2
Association between dietary vitamin B1 intake and cognitive performance in DSST, AFT, CERAD-IRT, CERAD-DRT and z score. Solid and dashed lines represent the predicted value and 95% confidence intervals. Adjusted for age, gender, race/ethnicity, poverty income ratio, marital status, education level, body mass index, smoking status, alcohol status, hypertension, diabetes mellitus, cardiovascular disease history and stroke. Only 99% of the data is shown
Fig. 3
Fig. 3
Stratified analyses of the association between cognitive performance and dietary vitamin B1 intake according to baseline characteristics in z score test. The P value for interaction represents the likelihood of interaction between the variable and vitamin B1. CI confidence interval
See this image and copyright information in PMC

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