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. 2024 Feb 14;15(2):e0308023.
doi: 10.1128/mbio.03080-23. Epub 2024 Jan 9.

Candida auris detected in the oral cavity of a dog in Kansas

Theodore C White  1 , Brooke D Esquivel  1 , Elisa M Rouse Salcido  1 , Allison M Schweiker  1 , Amanda R Dos Santos  2 , Lalitha Gade  2 , Erin Petro  3 , Butch KuKanich  4 , Kate S KuKanich  5
Affiliations

Candida auris detected in the oral cavity of a dog in Kansas

Theodore C White et al. mBio. .

Abstract

Candida auris is an emerging human fungal pathogen, first described in Japan in 2009, and first detected in the United States in 2016. Here, we report the first-ever description of C. auris colonizing a human pet, the first identification of C. auris in a non-human mammal in the United States and the first C. auris isolate from the state of Kansas. While analyzing the oral mycobiome of dogs from a shelter in Kansas, the oral swab from one dog was found to contain C. auris as well as three other fungal species. The presence of C. auris in a dog suggests the possibility of zoonotic transmission to humans. The isolate is a member of Clade IV, which has been found in patients in Chicago and Florida, while Clades I and III are the most prevalent in the United States. The isolate is resistant to fluconazole, terbinafine, and amphotericin B but susceptible to caspofungin, consistent with the drug-resistant characteristics of many human C. auris isolates. The source of C. auris transient colonization in this dog is unknown, and there is no evidence that it was further transmitted to humans, other dogs in the shelter, or pets in its adopted household. Isolation of C. auris from a dog in Kansas has public health implications as a potential emerging source for the zoonotic spread of this pathogenic fungus, and for the development of antifungal resistance.IMPORTANCECandida auris is an emerging fungal infection of humans and is particularly problematic because it is multi-drug resistant and difficult to treat. It is also known to be spread from person to person by contact and can remain on surfaces for long periods of time. In this report, a dog in a shelter in Kansas is found to be colonized with Candida auris. This is the first study to document the presence of Candida auris on a pet, the first to document C. auris presence on a non-human mammal in the United States, and the first to report an isolate of C. auris within the state of Kansas. The presence of C. auris in a pet dog raises the possibility of zoonotic transmission from pets to human or vice versa.

Keywords: Candida auris; Kansas; dog; phylogeny; resistance; zoonotic transmission.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig 1
Fig 1
Neighbor-Joining phylogenetic tree of C. auris isolates. Square colors represent the different C. auris clades. Branch lengths represent single nucleotide polymorphisms. The C. auris isolate from the dog in Kansas is starred (B24973). The 109 random isolates are being used in a collaboration with the CDC and the White laboratory.
See this image and copyright information in PMC

Comment in

References

    1. Lockhart SR. 2019. Candida auris and multidrug resistance: defining the new normal. Fungal Genet Biol 131:103243. doi:10.1016/j.fgb.2019.103243 - DOI - PMC - PubMed
    1. Joseph Sexton D, Bentz ML, Welsh RM, Derado G, Furin W, Rose LJ, Noble-Wang J, Pacilli M, McPherson TD, Black S, Kemble SK, Herzegh O, Ahmad A, Forsberg K, Jackson B, Litvintseva AP. 2021. Positive correlation between Candida auris skin-colonization burden and environmental contamination at a ventilator-capable skilled nursing facility in Chicago. Clin Infect Dis 73:1142–1148. doi:10.1093/cid/ciab327 - DOI - PMC - PubMed
    1. Forsberg K, Woodworth K, Walters M, Berkow EL, Jackson B, Chiller T, Vallabhaneni S. 2019. Candida auris: the recent emergence of a multidrug-resistant fungal pathogen. Med Mycol 57:1–12. doi:10.1093/mmy/myy054 - DOI - PubMed
    1. Arora P, Singh P, Wang Y, Yadav A, Pawar K, Singh A, Padmavati G, Xu J, Chowdhary A. 2021. Environmental isolation of Candida auris from the coastal wetlands of Andaman Islands, India. mBio 12:e03181-20. doi:10.1128/mBio.03181-20 - DOI - PMC - PubMed
    1. Yadav A, Jain K, Wang Y, Pawar K, Kaur H, Sharma KK, Tripathy V, Singh A, Xu J, Chowdhary A. 2022. Candida auris on apples: diversity and clinical significance. mBio 13:e0051822. doi:10.1128/mbio.00518-22 - DOI - PMC - PubMed

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