Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec;23(12):7632-7642.
doi: 10.1111/1462-2920.15660. Epub 2021 Jul 16.

Azole-resistant Aspergillus fumigatus is highly prevalent in the environment of Vietnam, with marked variability by land use type

Tra-My N Duong  1   2 , Thanh-Van Le  2 , Khanh-Linh H Tran  2 , Phuong-Tuyen Nguyen  2 , Bich-Phuong T Nguyen  3 , Thu-Anh Nguyen  3 , Huong-Lan P Nguyen  4 , Bich-Ngoc T Nguyen  5   6 , Matthew C Fisher  7 , Johanna Rhodes  7 , Guy Marks  3 , Greg J Fox  1   3 , Sharon C-A Chen  8   9 , Michael G Walsh  1   8 , Vanessa R Barrs  8   10 , Jessica Talbot  11 , Catriona L Halliday  8   9 , Tania C Sorrell  1   8   12 , Jeremy N Day  2   13 , Justin Beardsley  1   2   8   12
Affiliations

Azole-resistant Aspergillus fumigatus is highly prevalent in the environment of Vietnam, with marked variability by land use type

Tra-My N Duong et al. Environ Microbiol. 2021 Dec.

Abstract

Azole-resistant environmental Aspergillus fumigatus presents a threat to public health but the extent of this threat in Southeast Asia is poorly described. We conducted environmental surveillance in the Mekong Delta region of Vietnam, collecting air and ground samples across key land-use types, and determined antifungal susceptibilities of Aspergillus section Fumigati (ASF) isolates and azole concentrations in soils. Of 119 ASF isolates, 55% were resistant (or non-wild type) to itraconazole, 65% to posaconazole and 50% to voriconazole. Azole resistance was more frequent in A. fumigatus sensu stricto isolates (95%) than other ASF species (32%). Resistant isolates and agricultural azole residues were overrepresented in samples from cultivated land. cyp51A gene sequence analysis showed 38/56 resistant A. fumigatus sensu stricto isolates carried known resistance mutations, with TR34 /L98H most frequent (34/38).

PubMed Disclaimer

Comment in

References

    1. Abdolrasouli, A., Rhodes, J., Beale, M.A., Hagen, F., Rogers, T.R., Chowdhary, A., et al. (2015) Genomic context of azole resistance mutations in Aspergillus fumigatus determined using whole-genome sequencing. MBio 6: e00536.
    1. Ahmad, S., Khan, Z., Hagen, F., and Meis, J.F. (2014) Occurrence of triazole-resistant Aspergillus fumigatus with TR34/L98H mutations in outdoor and hospital environment in Kuwait. Environ Res 133: 20-26.
    1. Altschul, S.F., Gish, W., Miller, W., Myers, E.W., and Lipman, D.J. (1990) Basic local alignment search tool. J Mol Biol 215: 403-410.
    1. Anastassiades, M., Lehotay, S.J., Stajnbaher, D., and Schenck, F.J. (2003) Fast and easy multiresidue method employing acetonitrile extraction/partitioning and “dispersive solid-phase extraction” for the determination of pesticide residues in produce. J AOAC Int 86: 412-431.
    1. Anuradha, C., Cheshta, S., Mara van den, B., Jan Bart, Y., Ferry, H., Paul E., V., and Jacques F., M. (2014) Multi-azole-resistant Aspergillus fumigatus in the environment in Tanzania. J Antimicrob Chemother 69: 2979-2983.

Publication types

LinkOut - more resources