Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 May-Jun;87(3):326-332.
doi: 10.25259/IJDVL_302_20.

The unprecedented epidemic-like scenario of dermatophytosis in India: II. Diagnostic methods and taxonomical aspects

Shyam B Verma  1 , Saumya Panda  2 , Pietro Nenoff  3 , Archana Singal  4 , Shivaprakash M Rudramurthy  5 , Silke Uhrlass  3 , Anupam Das  6 , Kavita Bisherwal  7 , Dipika Shaw  8 , Resham Vasani  9
Affiliations
Free article
Review

The unprecedented epidemic-like scenario of dermatophytosis in India: II. Diagnostic methods and taxonomical aspects

Shyam B Verma et al. Indian J Dermatol Venereol Leprol. 2021 May-Jun.
Free article

Abstract

Trichophyton (T.) mentagrophytes now accounts for an overwhelming majority of clinical cases in India, a new "Indian genotype" (T. mentagrophytes ITS genotype VIII) having been isolated from skin samples obtained from cases across a wide geographical distribution in this country. The conventional diagnostic methods, like fungal culture, are, however, inadequate for diagnosing this agent. Thus, molecular methods of diagnosis are necessary for proper characterization of the causative agent. The shift in the predominant agent of dermatophytosis from T. rubrum to T. mentagrophytes, within a relatively short span of time, is without historic parallel. The apparent ease of transmission of a zoophilic fungus among human hosts can also be explained by means of mycological phenomena, like anthropization.

Keywords: Anthropization; T. mentagrophytes ITS genotype VIII; Trichophyton mentagrophytes; phylogenetic tree.

PubMed Disclaimer

References

    1. Nenoff P, Krüger C, Schaller J, Ginter-Hanselmayer G, SchulteBeerbühl R, Tietz HJ,. Mycology-an update part 2: Dermatomycoses: Clinical picture and diagnostics. J Dtsch Dermatol Ges. 2014; 12:749-77 - DOI - PubMed
    1. Khurana A, Masih A, Chowdhary A, Sardana K, Borker S, Gupta A, et al. Correlation of in vitro susceptibility based on MICs and squalene epoxidase mutations with clinical response to terbinafine in patients with tinea corporis/cruris. Antimicrob Agents Chemother. 2018; 62:e01038-18 - DOI - PubMed
    1. Rudramurthy SM, Shankarnarayan SA, Dogra S, Shaw D, Mushtaq K, Paul RA, et al. Mutation in the squalene epoxidase gene of Trichophyton interdigitale and trichophyton rubrum associated with allylamine resistance. Antimicrob Agents Chemother. 2018; 62:e02522-17 - DOI - PubMed
    1. Singh A, Masih A, Khurana A, Singh PK, Gupta M, Hagen F, et al. High terbinafine resistance in Trichophyton interdigitale isolates in Delhi, India harbouring mutations in the squalene epoxidase gene. Mycoses. 2018; 61:477-84 - DOI - PubMed
    1. Rudramurthy S, Shaw D,. Overview and update on the laboratory diagnosis of dermatophytosis. Clin Dermatol Rev. 2017; 1:3 - DOI

LinkOut - more resources