Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Aug 5;222(Suppl 3):S175-S198.
doi: 10.1093/infdis/jiaa394.

Core Recommendations for Antifungal Stewardship: A Statement of the Mycoses Study Group Education and Research Consortium

Melissa D Johnson  1 , Russell E Lewis  2 , Elizabeth S Dodds Ashley  1 , Luis Ostrosky-Zeichner  3 , Theoklis Zaoutis  4 , George R Thompson  5 , David R Andes  6 , Thomas J Walsh  7 , Peter G Pappas  8 , Oliver A Cornely  9   10   11   12 , John R Perfect  1 , Dimitrios P Kontoyiannis  13
Affiliations
Review

Core Recommendations for Antifungal Stewardship: A Statement of the Mycoses Study Group Education and Research Consortium

Melissa D Johnson et al. J Infect Dis. .

Abstract

In recent years, the global public health community has increasingly recognized the importance of antimicrobial stewardship (AMS) in the fight to improve outcomes, decrease costs, and curb increases in antimicrobial resistance around the world. However, the subject of antifungal stewardship (AFS) has received less attention. While the principles of AMS guidelines likely apply to stewarding of antifungal agents, there are additional considerations unique to AFS and the complex field of fungal infections that require specific recommendations. In this article, we review the literature on AMS best practices and discuss AFS through the lens of the global core elements of AMS. We offer recommendations for best practices in AFS based on a synthesis of this evidence by an interdisciplinary expert panel of members of the Mycoses Study Group Education and Research Consortium. We also discuss research directions in this rapidly evolving field. AFS is an emerging and important component of AMS, yet requires special considerations in certain areas such as expertise, education, interventions to optimize utilization, therapeutic drug monitoring, and data analysis and reporting.

Keywords: antifungal; aspergillosis; candidiasis; diagnostics; guidelines; stewardship.

PubMed Disclaimer

Comment in

References

    1. des Champs-Bro B, Leroy-Cotteau A, Mazingue F, et al. . Invasive fungal infections: epidemiology and analysis of antifungal prescriptions in onco-haematology. J Clin Pharm Ther 2011; 36:152–60. - PubMed
    1. Muñoz P, Valerio M, Vena A, Bouza E. Antifungal stewardship in daily practice and health economic implications. Mycoses 2015; 58(Suppl 2):14–25. - PubMed
    1. Valerio M, Rodriguez-Gonzalez CG, Muñoz P, Caliz B, Sanjurjo M, Bouza E; COMIC Study Group (Collaborative Group on Mycoses) Evaluation of antifungal use in a tertiary care institution: antifungal stewardship urgently needed. J Antimicrob Chemother 2014; 69:1993–9. - PubMed
    1. Azoulay E, Dupont H, Tabah A, et al. . Systemic antifungal therapy in critically ill patients without invasive fungal infection. Crit Care Med 2012; 40:813–22. - PubMed
    1. Stultz JS, Kohinke R, Pakyz AL. Variability in antifungal utilization among neonatal, pediatric, and adult inpatients in academic medical centers throughout the United States of America. BMC Infect Dis 2018; 18:501. - PMC - PubMed

Publication types

MeSH terms

Substances