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. 2018 Apr-Jun;12(2):114-122.
doi: 10.1590/1980-57642018dn12-020003.

Physical exercise, IGF-1 and cognition A systematic review of experimental studies in the elderly

Angelica Miki Stein  1 , Thays Martins Vital Silva  1   2 , Flávia Gomes de Melo Coelho  1   3 , Franciel José Arantes  1 , José Luiz Riani Costa  1 , Elizabeth Teodoro  4 , Ruth Ferreira Santos-Galduróz  4
Affiliations

Physical exercise, IGF-1 and cognition A systematic review of experimental studies in the elderly

Angelica Miki Stein et al. Dement Neuropsychol. 2018 Apr-Jun.

Abstract
in English, Portuguese

One of hypothetical mechanisms related to cognition is exercise-induced IGF-1.

Objective: The aim of this study was to analyze the effects of exercise on IGF-1 levels and cognition in the elderly.

Methods: The article searches were conducted on Pubmed, Web of Science, PsycINFO and Scielo databases and reviewed according to PRISMA guidelines. The inclusion criteria were: [1] original articles published up to 2017; [2] samples including elderly; [3] protocols including physical exercise; [4] longitudinal studies having exercise as main outcome; [5] assessment of IGF-1; [6] cognition assessment.

Results: Seven studies were included in this review. Three of the studies showed an exercise-induced increase in IGF-1; three found stable IGF-1 levels and one found a reduction in IGF-1; with and without improvement in cognition.

Conclusion: Disparities in the type of physical exercise, protocols and samples under different conditions hinder the establishment of a consensus on IGF-1, cognition and physical exercise.

Um dos mecanismos hipotéticos relacionados a cognição é o IGF-1 induzido pelo exercício.

Objetivo: O objetivo deste estudo foi analisar os efeitos do exercício físico nos níveis de IGF-1 e na cognição de idosos.

Métodos: A busca de artigos foi conduzida nas bases de dados Pubmed, Web of Science, PsycINFO e Scielo, revisada de acordo com as recomendações do PRISMA. O critério de inclusão adotado foi: [1] artigos originais publicados até 2017; [2] amostras incluindo idosos; [3] protocolos que incluíssem exercício físico; [4] ensaios randomizados, não randomizados, controlados e não controlados; [5] avaliação dos níveis de IGF-1; [6] avaliação cognitive.

Resultados: Sete estudos foram incluídos nesta revisão. Três deles mostraram aumento de IGF-1 por meio do exercício; três verificaram manutenção nos níveis de IGF-1 e um, verificou redução de IGF-1; com e sem melhora cognitive.

Conclusão: Diferenças nos tipos de exercício, protocolos, amostras em diferentes condições dificultam o estabelecimento de um consenso em relação ao IGF-1, cognição e exercício físico.

Keywords: cognition; exercise; older adults.

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Conflict of interest statement

Disclosure: The authors report no conflicts of interest.

Figures

Figure 1
Figure 1. The PRISMA flowchart of the systematic review.
See this image and copyright information in PMC

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