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Randomized Controlled Trial
. 2018 Jan 9;10(1):54.
doi: 10.3390/nu10010054.

Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention-A Preview Sub-Study

Grith Møller  1 , Jens Rikardt Andersen  2 , Christian Ritz  3 , Marta P Silvestre  4 , Santiago Navas-Carretero  5   6 , Elli Jalo  7 , Pia Christensen  8 , Elizabeth Simpson  9 , Moira Taylor  10 , J Alfredo Martinez  11   12   13 , Ian Macdonald  14 , Nils Swindell  15 , Kelly A Mackintosh  16 , Gareth Stratton  17 , Mikael Fogelholm  18 , Thomas M Larsen  19 , Sally D Poppitt  20 , Lars O Dragsted  21 , Anne Raben  22
Affiliations
Randomized Controlled Trial

Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention-A Preview Sub-Study

Grith Møller et al. Nutrients. .

Abstract

Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-year data in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention and kidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There were no associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.

Keywords: albumin; creatinine clearance; dietary protein; glomerular filtration rate; pre-diabetes; urea.

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Conflict of interest statement

Sally D. Poppitt holds the Fonterra Chair in Human Nutrition at the University of Auckland. None of the other authors declared a conflict of interest.

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