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. 2017 Oct 24;61(11):e01102-17.
doi: 10.1128/AAC.01102-17. Print 2017 Nov.

Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species

Wiley A Schell  1 , A M Jones  2 , Katyna Borroto-Esoda  3 , Barbara D Alexander  4
Affiliations

Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species

Wiley A Schell et al. Antimicrob Agents Chemother. .

Abstract

SCY-078 in vitro activity was determined for 178 isolates of resistant or susceptible Candida albicans, Candida dubliniensis, Candida glabrata, Candida krusei, Candida lusitaniae, and Candida parapsilosis, including 44 Candida isolates with known genotypic (FKS1 or FKS2 mutations), phenotypic, or clinical resistance to echinocandins. Results were compared to those for anidulafungin, caspofungin, micafungin, fluconazole, and voriconazole. SCY-078 was shown to have excellent activity against both wild-type isolates and echinocandin- and azole-resistant isolates of Candida species.

Keywords: Candida; antifungal agents; antifungal resistance.

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