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. 1988 Apr 27;149(1-2):171-4.
doi: 10.1016/0014-2999(88)90058-1.

Cocaine binding at sigma receptors

J Sharkey  1 , K A Glen, S Wolfe, M J Kuhar
Affiliations

Cocaine binding at sigma receptors

J Sharkey et al. Eur J Pharmacol. .

Abstract

Cocaine and some related psychostimulants interact with sigma receptors in binding assays. Their Ki values are compatible with blood concentrations reported to produce psychosis in human volunteers. It is proposed that the psychotomimetic effects of some psychostimulants may derive, at least in part, from their interaction with sigma receptors.

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