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Clinical Trial
. 2017 Mar;23(3):553-555.
doi: 10.3201/eid2303.161212.

Successful Treatment of Human Plague with Oral Ciprofloxacin

Titus Apangu, Kevin Griffith, Janet Abaru, Gordian Candini, Harriet Apio, Felix Okoth, Robert Okello, John Kaggwa, Sarah Acayo, Geoffrey Ezama, Brook Yockey, Christopher Sexton, Martin Schriefer, Edward Katongole Mbidde, Paul Mead
Clinical Trial

Successful Treatment of Human Plague with Oral Ciprofloxacin

Titus Apangu et al. Emerg Infect Dis. 2017 Mar.

Abstract

The US Food and Drug Administration recently approved ciprofloxacin for treatment of plague (Yersina pestis infection) based on animal studies. Published evidence of efficacy in humans is sparse. We report 5 cases of culture-confirmed human plague treated successfully with oral ciprofloxacin, including 1 case of pneumonic plague.

Keywords: FDA approval; Yersinia pestis; bacteria; bacterial infection; ciprofloxacin; human; infectious diseases; plague; treatment; vector-borne infections; zoonoses.

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