Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2014:2014:197216.
doi: 10.1155/2014/197216. Epub 2014 Apr 17.

Lifestyle intervention involving calorie restriction with or without aerobic exercise training improves liver fat in adults with visceral adiposity

Eiichi Yoshimura  1 , Hideaki Kumahara  2 , Takuro Tobina  3 , Takuro Matsuda  4 , Makoto Ayabe  5 , Akira Kiyonaga  4 , Keizo Anzai  6 , Yasuki Higaki  4 , Hiroaki Tanaka  7
Affiliations
Randomized Controlled Trial

Lifestyle intervention involving calorie restriction with or without aerobic exercise training improves liver fat in adults with visceral adiposity

Eiichi Yoshimura et al. J Obes. 2014.

Abstract

Objective: To evaluate the effect of calorie restriction-induced weight loss with or without aerobic exercise on liver fat.

Methods: Thirty-three adults with visceral adiposity were divided into calorie restriction (CR; n = 18) or CR and aerobic exercise (CR + Ex; n = 15) groups. Target energy intake was 25 kcal/kg of ideal body weight. The CR + Ex group had a targeted exercise time of 300 min/wk or more at lactate threshold intensity for 12 weeks.

Results: Reductions in body weight (CR, -5.3 ± 0.8 kg; CR + Ex, -5.1 ± 0.7 kg), fat mass (CR, -4.9 ± 0.9 kg; CR + Ex, -4.4 ± 0.6 kg), and visceral fat (CR, -24 ± 5 cm2; CR + Ex, -37 ± 5 cm2) were not statistically different between groups. Liver fat decreased significantly in both groups, with no difference between groups. Change in maximal oxygen uptake was significantly greater in the CR + Ex group than in the CR group (CR, -0.7 ± 0.7 mL/kg/min; CR + Ex, 2.9 ± 1.0 mL/kg/min).

Conclusion: Both CR and CR + Ex resulted in an improved reduction in liver fat; however, there was no additive effect of exercise training.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow of participants through the study.
See this image and copyright information in PMC

References

    1. Stefan N, Kantartzis K, Häring H-U. Causes and metabolic consequences of fatty liver. Endocrine Reviews. 2008;29(7):939–960. - PubMed
    1. Johnson NA, George J. Fitness versus fatness: moving beyond weight loss in nonalcoholic fatty liver disease. Hepatology. 2010;52(1):370–381. - PubMed
    1. Johnson NA, Sachinwalla T, Walton DW, et al. Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss. Hepatology. 2009;50(4):1105–1112. - PubMed
    1. Sullivan S, Kirk EP, Mittendorfer B, Patterson BW, Klein S. Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease. Hepatology. 2012;55(6):1738–1745. - PMC - PubMed
    1. Keating SE, Hackett DA, George J, Johnson NA. Exercise and non-alcoholic fatty liver disease: a systematic review and meta-analysis. Journal of Hepatology. 2012;57(1):157–166. - PubMed

Publication types