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Meta-Analysis
. 2014 Mar;18(3):187-95.
doi: 10.1089/gtmb.2013.0425. Epub 2014 Feb 19.

Association between six genetic polymorphisms and colorectal cancer: a meta-analysis

Cheng Chen  1 , Lingyan Wang, Qi Liao, Leiting Xu, Yi Huang, Cheng Zhang, Huadan Ye, Xuting Xu, Meng Ye, Shiwei Duan
Affiliations
Meta-Analysis

Association between six genetic polymorphisms and colorectal cancer: a meta-analysis

Cheng Chen et al. Genet Test Mol Biomarkers. 2014 Mar.

Abstract

Objective: The aim of this study was to determine whether six genetic polymorphisms confer susceptibility to colorectal cancer (CRC).

Methods: A systematic search for candidate genes of CRC was performed among several online databases, including PubMed, Embase, Web of Science, the Cochrane Library, CNKI, and Wanfang online libraries. After a comprehensive filtering procedure, we harvested five genes, including MGMT (rs12917 and rs2308321), ADH1B (rs1229984), SOD2 (rs4880), XPC (rs2228001), and PPARG (rs1801282). Using the REVMAN and Stata software, six meta-analyses were conducted for associations between CRC and the just-mentioned genetic variants.

Results: A total of 34 comparative studies among 17,289 cases and 54,927 controls were involved in our meta-analyses. Significant association was found between ADH1B rs1229984 polymorphism and CRC (p=0.03, odds ratio [OR]=1.18, 95% confidence interval [CI]=1.01-1.36). We also found significant association between PPARG rs1801282 polymorphism and CRC (p=0.004, OR=1.498, 95% CI=1.139-1.970), and this significant association is specific in Caucasians (p=0.004, OR=1.603, 95% CI=1.165-2.205).

Conclusions: The current meta-analysis has established that ADH1B (rs1229984) and PPARG (rs1801282) are two risk variants of CRC.

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Figures

<b>FIG. 1.</b>
FIG. 1.
Flow diagram for selection of studies.
<b>FIG. 2.</b>
FIG. 2.
Forest plots for the case–control studies between five polymorphisms and colorectal cancer (CRC) in our meta-analysis.
<b>FIG. 3.</b>
FIG. 3.
Forest plots for the case–control studies between rs1801282 of PPARG and CRC in our meta-analysis.
<b>FIG. 4.</b>
FIG. 4.
Publication bias test of five polymorphisms in our meta-analysis. (A) Publication bias test of rs1229984 of the ADH1B gene. (B) Publication bias test of rs4880 of the SOD2 gene. (C) Publication bias test of rs12917 of the MGMT gene. (D) Publication bias test of rs2308321 of the MGMT gene. (E) Publication bias test of rs2228001 of the XPC gene.
<b>FIG. 5.</b>
FIG. 5.
Publication bias test of PPARG rs1801282 polymorphism in our meta-analysis. (A) Begg's funnel plot of rs1801282 of the PPARG gene. (B) Egger's funnel plot of rs1801282 of the PPARG gene.
See this image and copyright information in PMC

References

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