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Review
. 2008 Aug 31;136(1-2):3-10.
doi: 10.1016/j.jbiotec.2008.03.021. Epub 2008 Jun 21.

The Genome Sequencer FLX System--longer reads, more applications, straight forward bioinformatics and more complete data sets

Marcus Droege  1 , Brendon Hill
Affiliations
Review

The Genome Sequencer FLX System--longer reads, more applications, straight forward bioinformatics and more complete data sets

Marcus Droege et al. J Biotechnol. .

Abstract

The Genome Sequencer FLX System (GS FLX), powered by 454 Sequencing, is a next-generation DNA sequencing technology featuring a unique mix of long reads, exceptional accuracy, and ultra-high throughput. It has been proven to be the most versatile of all currently available next-generation sequencing technologies, supporting many high-profile studies in over seven applications categories. GS FLX users have pursued innovative research in de novo sequencing, re-sequencing of whole genomes and target DNA regions, metagenomics, and RNA analysis. 454 Sequencing is a powerful tool for human genetics research, having recently re-sequenced the genome of an individual human, currently re-sequencing the complete human exome and targeted genomic regions using the NimbleGen sequence capture process, and detected low-frequency somatic mutations linked to cancer.

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