In this article, we show that a psychological view of global and situational meanings is inadequate for understanding meaning making in the context of breast cancer. We outline research that has illuminated breast cancer meanings that differ from standard illness meanings and we highlight impediments to meaning making for women with breast cancer. We conclude that it is less helpful to promote a particular kind of illness meaning for women with breast cancer than to: (a) create conditions that women with breast cancer have said are conducive to meaning making; (b) accept and acknowledge meanings that women with breast cancer themselves find valuable; and (c) actively work to change dominant discourses that constrain meaning making for women with breast cancer.