SG10201801503XA - e-POLYLYSINE CONJUGATES AND USE THEREOF - Google Patents

e-POLYLYSINE CONJUGATES AND USE THEREOF

Info

Publication number
SG10201801503XA
SG10201801503XA SG10201801503XA SG10201801503XA SG10201801503XA SG 10201801503X A SG10201801503X A SG 10201801503XA SG 10201801503X A SG10201801503X A SG 10201801503XA SG 10201801503X A SG10201801503X A SG 10201801503XA SG 10201801503X A SG10201801503X A SG 10201801503XA
Authority
SG
Singapore
Prior art keywords
polylysine conjugates
polylysine
conjugates
Prior art date
Application number
SG10201801503XA
Inventor
Armin Kuebelbeck
Gregor Larbig
Walter Mier
Barbro Beijer
Uwe Haberkorn
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SG10201801503XA publication Critical patent/SG10201801503XA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542Carboxylic acids, e.g. a fatty acid or an amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • A61K49/14Peptides, e.g. proteins
    • A61K49/146Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0497Organic compounds conjugates with a carrier being an organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
SG10201801503XA 2009-07-20 2010-07-09 e-POLYLYSINE CONJUGATES AND USE THEREOF SG10201801503XA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09009393A EP2277547A1 (en) 2009-07-20 2009-07-20 Epsilon-polylysine conjugates and their utilisation

Publications (1)

Publication Number Publication Date
SG10201801503XA true SG10201801503XA (en) 2018-04-27

Family

ID=41278643

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2012002283A SG177629A1 (en) 2009-07-20 2010-07-09 e-POLYLYSINE CONJUGATES AND USE THEREOF
SG10201801503XA SG10201801503XA (en) 2009-07-20 2010-07-09 e-POLYLYSINE CONJUGATES AND USE THEREOF

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2012002283A SG177629A1 (en) 2009-07-20 2010-07-09 e-POLYLYSINE CONJUGATES AND USE THEREOF

Country Status (22)

Country Link
US (1) US9078929B2 (en)
EP (2) EP2277547A1 (en)
JP (1) JP5819824B2 (en)
KR (2) KR101946070B1 (en)
CN (1) CN102470181B (en)
AU (1) AU2010275778B2 (en)
BR (1) BR112012001260B1 (en)
CA (1) CA2768547C (en)
DK (1) DK2456467T3 (en)
EA (1) EA022137B1 (en)
ES (1) ES2689147T3 (en)
HR (1) HRP20181493T1 (en)
HU (1) HUE039397T2 (en)
IL (1) IL217603A (en)
LT (1) LT2456467T (en)
MX (1) MX2012000575A (en)
PL (1) PL2456467T3 (en)
PT (1) PT2456467T (en)
SG (2) SG177629A1 (en)
SI (1) SI2456467T1 (en)
WO (1) WO2011009539A1 (en)
ZA (1) ZA201201218B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2971713B1 (en) * 2011-02-18 2019-03-29 Laboratoire De La Mer AQUEOUS IONIC SOLUTION CONTAINING SEA WATER AND AT LEAST ONE COMPOUND ORIGINALLY UNMISCIBLE TO SEA WATER.
GB201106742D0 (en) * 2011-04-20 2011-06-01 Spheritech Ltd Cross-linked poly-e-lysine
EP2826785B1 (en) * 2012-03-13 2017-08-09 National University Corporation Okayama University Lysine oligomer derivative and cartilage tissue marker made thereof
CN103421187A (en) * 2012-05-18 2013-12-04 华中科技大学同济医学院附属协和医院 Method for preparing cyclosporin A holoantigen
WO2014094312A1 (en) * 2012-12-21 2014-06-26 上海迪赛诺化学制药有限公司 Method for synthesizing nucleoside amino acid derivatives through enzyme catalysis
ES2697250T3 (en) * 2013-05-07 2019-01-22 Merck Patent Gmbh Conjugates for the protection of substances with nephrotoxic effect
HRP20181882T1 (en) 2013-05-07 2019-01-11 Merck Patent Gmbh PEPTIDES AND CONJUGATES PEPTIDES-ACTIVE INGREDIENT FOR DRUG TARGETING
CN104055787B (en) * 2013-07-25 2017-04-26 北京蓝贝望生物医药科技股份有限公司 Medicinal water-soluble antifungal macromolecular compound
GB201409451D0 (en) 2014-05-28 2014-07-09 Ipabc Ltd Antimicrobial preparations, methods for preparing the same and uses thereof to combat microorganisms
JP6398419B2 (en) * 2014-07-23 2018-10-03 コニカミノルタ株式会社 Labeling agent containing sorafenib
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
JP7123414B2 (en) * 2017-08-23 2022-08-23 公立大学法人福井県立大学 ε-POLY-L-LYSINE DERIVATIVE WITH CLICK FUNCTIONAL GROUP, PRODUCTION METHOD THEREOF, AND USE THEREOF
US10799138B2 (en) 2018-04-05 2020-10-13 University Of Maryland, Baltimore Method of administering sotalol IV/switch
US11344518B2 (en) 2018-08-14 2022-05-31 AltaThera Pharmaceuticals LLC Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame
US12396970B2 (en) 2021-08-20 2025-08-26 AltaThera Pharmaceuticals LLC Anti-arrhythmic compositions and methods
US11696902B2 (en) 2018-08-14 2023-07-11 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
US10512620B1 (en) 2018-08-14 2019-12-24 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
US11610660B1 (en) 2021-08-20 2023-03-21 AltaThera Pharmaceuticals LLC Antiarrhythmic drug dosing methods, medical devices, and systems
KR102300091B1 (en) 2019-11-07 2021-09-08 가톨릭대학교 산학협력단 ε-poly(L-lysine) polymer nanogel which has endosomolytic activity and reductive degradability, Its synthesis, and Use thereof
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections
CN114159461A (en) * 2021-11-23 2022-03-11 同济大学 Penicillin-modified epsilon-polylysine antibacterial peptide and preparation method thereof
CN114350590B (en) * 2021-12-24 2024-06-25 大连大学 Ion response microcapsule and preparation method and application thereof
WO2024177082A1 (en) * 2023-02-22 2024-08-29 公立大学法人福井県立大学 Oral pharmaceutical composition containing cell membrane-penetrating polycationic isopeptide, polyion complex composite, production method thereof, and oral insulin formulation
CN119679969A (en) * 2025-02-11 2025-03-25 南京康舟医药科技有限公司 A teriparatide oral preparation and its preparation method and application

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0471790A4 (en) * 1989-05-04 1992-07-08 Wisconsin Alumni Research Foundation Method for localization and treatment of tumors and complexes therefor
AU2003221699A1 (en) * 2002-04-09 2003-10-27 Taisho Pharmaceutical Co., Ltd. Pharmaceutical preparation for taste masking
US8173840B2 (en) 2003-07-29 2012-05-08 Signature R&D Holdings, Llc Compounds with high therapeutic index
EP1888115A2 (en) * 2005-05-16 2008-02-20 Universite De Geneve Compounds for photochemotherapy
EP2076557A4 (en) * 2006-08-11 2012-08-29 Starpharma Pty Ltd Polylysine dendrimer contrast agent
WO2009151687A2 (en) * 2008-03-12 2009-12-17 The Regents Of The University Of Michigan Dendrimer conjugates

Also Published As

Publication number Publication date
ES2689147T3 (en) 2018-11-08
WO2011009539A8 (en) 2011-03-24
AU2010275778B2 (en) 2016-05-05
IL217603A (en) 2017-04-30
US9078929B2 (en) 2015-07-14
PT2456467T (en) 2018-10-24
CN102470181A (en) 2012-05-23
EA201200122A1 (en) 2012-07-30
MX2012000575A (en) 2012-03-06
WO2011009539A1 (en) 2011-01-27
SG177629A1 (en) 2012-03-29
KR20170037674A (en) 2017-04-04
HRP20181493T1 (en) 2018-11-16
AU2010275778A1 (en) 2012-03-08
JP5819824B2 (en) 2015-11-24
KR101946070B1 (en) 2019-02-08
PL2456467T3 (en) 2018-11-30
LT2456467T (en) 2018-09-25
SI2456467T1 (en) 2018-11-30
CA2768547C (en) 2018-10-23
BR112012001260B1 (en) 2022-05-24
JP2012533579A (en) 2012-12-27
CA2768547A1 (en) 2011-01-27
ZA201201218B (en) 2012-11-28
HUE039397T2 (en) 2018-12-28
US20120122788A1 (en) 2012-05-17
EP2456467A1 (en) 2012-05-30
KR20120047263A (en) 2012-05-11
EP2456467B1 (en) 2018-06-27
DK2456467T3 (en) 2018-10-08
BR112012001260A2 (en) 2016-02-10
EA022137B1 (en) 2015-11-30
EP2277547A1 (en) 2011-01-26
CN102470181B (en) 2014-12-03

Similar Documents

Publication Publication Date Title
SG10201801503XA (en) e-POLYLYSINE CONJUGATES AND USE THEREOF
ZA201107757B (en) Anti-mesothelin immunoconjugates and uses thereof
IL216719A0 (en) Pure-peg-lipid conjugates
SG2014012918A (en) Albumin variants and conjugates
GB0914644D0 (en) Novel agents and uses thereof
ZA201204700B (en) Optimized endonucleases and uses thereof
ZA201109034B (en) Aminopyrrolidinone derivatives and uses thereof
IL210804A (en) Benzylidenehydrazides and uses thereof
SG173666A1 (en) Isoxazole-isoxazole and isoxazole-isothiazole derivatives
ZA201106702B (en) Sceletium extract and uses thereof
EP2291377A4 (en) Imidazopyrimidinones and uses thereof
ZA201103456B (en) Leukolectins and uses thereof
PL2247601T3 (en) Thiazopyrimidinones and uses thereof
IL213207A0 (en) Dihydroetorphines and their preparation
IL220427A (en) Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof
IL216626A0 (en) Albumin-amyloid peptide conjugates and uses thereof
GB0902173D0 (en) Compounds and their use
GB0912744D0 (en) Methods and uses
IL218869A (en) Oligomer-calcimimetic conjugates and compositions comprising the same
GB0922510D0 (en) Compound and use
ZA201200260B (en) Polyphenylsulphone-polytetrafluroethylene compositions and use thereof
GB0906023D0 (en) Insulin-Nanoparticle conjugates
GB0906115D0 (en) Antibody and uses thereof
GB0909792D0 (en) Composition and uses thereof
GB0910620D0 (en) Agents and uses thereof