GB1036368A - Method for the manufacture of lactose-containing tablets - Google Patents
Method for the manufacture of lactose-containing tabletsInfo
- Publication number
- GB1036368A GB1036368A GB4247964A GB4247964A GB1036368A GB 1036368 A GB1036368 A GB 1036368A GB 4247964 A GB4247964 A GB 4247964A GB 4247964 A GB4247964 A GB 4247964A GB 1036368 A GB1036368 A GB 1036368A
- Authority
- GB
- United Kingdom
- Prior art keywords
- lactose
- syrup
- beta
- water
- tablets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 title abstract 14
- 239000008101 lactose Substances 0.000 title abstract 14
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 14
- GUBGYTABKSRVRQ-DCSYEGIMSA-N Beta-Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-DCSYEGIMSA-N 0.000 abstract 5
- 239000006188 syrup Substances 0.000 abstract 5
- 235000020357 syrup Nutrition 0.000 abstract 5
- 229930195724 β-lactose Natural products 0.000 abstract 5
- 238000001035 drying Methods 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000005862 Whey Substances 0.000 abstract 1
- 102000007544 Whey Proteins Human genes 0.000 abstract 1
- 108010046377 Whey Proteins Proteins 0.000 abstract 1
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 1
- 235000008504 concentrate Nutrition 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 229930195727 α-lactose Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K5/00—Lactose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Lactose, which contains at least 50% by weight beta-lactose, is prepared by drying or crystallizing a syrup or solution of lactose in water at a temperature above 200 DEG F. The preferred method comprises roll drying a syrup preprepared by dissolving in water lactose that has been recrystallized from whey concentrate, the syrup containing about 35 to 50% by weight of lactose. The syrup is fed into the bite of a double drum dryer, whose rollers are steam heated to 265 DEG to 340 DEG F., and thus dried to give a product containing about 0.3% of water, and about 75% of beta-lactose, the remainder being alpha-lactose.ALSO:Lactose-containing tablets, wherein the lactose comprises a major proportion of beta-lactose, and constitutes at least 25% by weight of the tablet, are prepared by forming a free-flowing mixture of an active ingredient and the lactose, and forming into tablets in the absence of added moisture. Suitable lactose, having a beta-lactose content of at least 50%, may be prepared by crystallising the lactose from aqueous solution, preferably a syrup, at a temperature above 200 DEG F. (e.g. by roll-drying on steam-heated rollers; see Division C2). The lactose may be colored by adding a water-soluble dye to the aqueous solution. An example is given for preparing tablets containing aspirin or soy-flour as the active ingredient, using a 75% by weight beta-lactose-containing roll-dried lactose. The tablets made from such lactose are said to be more resistant to capping and more readily water-soluble than those of the usual, mainly alpha, lactose.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32050563A | 1963-10-31 | 1963-10-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1036368A true GB1036368A (en) | 1966-07-20 |
Family
ID=23246735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4247964A Expired GB1036368A (en) | 1963-10-31 | 1964-10-19 | Method for the manufacture of lactose-containing tablets |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE1258549B (en) |
| GB (1) | GB1036368A (en) |
| NL (1) | NL145140B (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2042386A1 (en) * | 1969-04-29 | 1971-02-12 | Sucrest Corp | |
| WO1994012200A1 (en) * | 1992-12-02 | 1994-06-09 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids |
| US5935602A (en) * | 1991-11-22 | 1999-08-10 | The Procter & Gamble Company | Dosage forms of risedronate |
| US6406714B1 (en) | 1992-12-02 | 2002-06-18 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids |
| US6596710B1 (en) | 1991-11-22 | 2003-07-22 | The Procter & Gamble Company | Dosage forms of risedronate |
| US6623755B2 (en) | 1999-07-01 | 2003-09-23 | Merck & Co., Inc. | Pharmaceutical tablets |
| EP1498498A1 (en) * | 2003-07-15 | 2005-01-19 | Kraft Foods R & D, Inc. | Whey powders of improved taste |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL9100691A (en) * | 1991-04-19 | 1992-11-16 | Dmv Campina Bv | TABLETING AUXILIARY. |
-
1964
- 1964-10-19 GB GB4247964A patent/GB1036368A/en not_active Expired
- 1964-10-30 DE DEN25753A patent/DE1258549B/en active Pending
- 1964-10-30 NL NL6412650A patent/NL145140B/en unknown
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2042386A1 (en) * | 1969-04-29 | 1971-02-12 | Sucrest Corp | |
| US6596710B1 (en) | 1991-11-22 | 2003-07-22 | The Procter & Gamble Company | Dosage forms of risedronate |
| US5935602A (en) * | 1991-11-22 | 1999-08-10 | The Procter & Gamble Company | Dosage forms of risedronate |
| EP0690719A1 (en) | 1992-12-02 | 1996-01-10 | Merck & Co. Inc. | Dry mix formulation for bisphosphonic acids |
| US5681590A (en) * | 1992-12-02 | 1997-10-28 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids |
| US5882656A (en) * | 1992-12-02 | 1999-03-16 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids |
| US5358941A (en) * | 1992-12-02 | 1994-10-25 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids with lactose |
| US6090410A (en) * | 1992-12-02 | 2000-07-18 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids |
| US6194004B1 (en) | 1992-12-02 | 2001-02-27 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids |
| US6406714B1 (en) | 1992-12-02 | 2002-06-18 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids |
| US6517867B2 (en) | 1992-12-02 | 2003-02-11 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids |
| WO1994012200A1 (en) * | 1992-12-02 | 1994-06-09 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids |
| US6623755B2 (en) | 1999-07-01 | 2003-09-23 | Merck & Co., Inc. | Pharmaceutical tablets |
| EP1498498A1 (en) * | 2003-07-15 | 2005-01-19 | Kraft Foods R & D, Inc. | Whey powders of improved taste |
Also Published As
| Publication number | Publication date |
|---|---|
| NL145140B (en) | 1975-03-17 |
| DE1258549B (en) | 1968-01-11 |
| NL6412650A (en) | 1965-05-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1022923A (en) | Polypyrrolidone solutions | |
| GB963992A (en) | Process and apparatus for the treatment of cereals | |
| GB1036368A (en) | Method for the manufacture of lactose-containing tablets | |
| PT79899B (en) | PROCESS FOR THE PREPARATION OF A DISPERSIBLE STARCH IN BOTTLING WATER | |
| GB1055385A (en) | Improvements in or relating to a sugar product and method of making same | |
| GB998649A (en) | Sodium perborate | |
| KR890009961A (en) | High purity crystalline lactulose and preparation method thereof | |
| GB1106139A (en) | Production of juice from sugar containing plant material | |
| GB1232554A (en) | ||
| GB1434061A (en) | Process for purification | |
| GB438436A (en) | Improvements in the production of cellulose and cellulosic products | |
| GB779262A (en) | Process for fractionating starch | |
| GB1277067A (en) | Process for the manufacture of partially hydrated sodium tripolyphosphate | |
| US2324113A (en) | Method of making dextrose | |
| GB838667A (en) | Process for forming sodium perborate crumbs | |
| GB992742A (en) | Preparation of permonosulphates | |
| ES393213A1 (en) | A PROCEDURE FOR THE MANUFACTURE OF DRY HYDROPHOBIC STARCH DERIVATIVES. | |
| GB973874A (en) | Process for the drying of solid products mixed with or dissolved in liquid | |
| SU137887A1 (en) | The method of boiling down the tomato mass and similar products in a vacuum apparatus | |
| GB883255A (en) | Preparation of chloro-substituted gamma-phenoxy butyric acids | |
| BE561234A (en) | PROCESS FOR THE PREPARATION OF NEW DERIVATIVES OF 1-AZA- (2.3: 5.6) -DIBENZOCYCLOHEPTADIENE, THEIR ACID SALTS AND THEIR QUATERNARY SALTS. | |
| SU459958A1 (en) | Method of obtaining n-phenyl-2-naphthylamine | |
| GB1202670A (en) | Process for dehydrating hydrated salts | |
| GB913442A (en) | Improvements in or relating to the preparation of urea suitable for granulation | |
| HAYASHI et al. | Constitution of Meratin |