ECSP12011632A - PROPHARMS THAT INCLUDE AN INSULIN-CONNECTOR CONJUGATE - Google Patents
PROPHARMS THAT INCLUDE AN INSULIN-CONNECTOR CONJUGATEInfo
- Publication number
- ECSP12011632A ECSP12011632A ECSP12011632A ECSP12011632A EC SP12011632 A ECSP12011632 A EC SP12011632A EC SP12011632 A ECSP12011632 A EC SP12011632A EC SP12011632 A ECSP12011632 A EC SP12011632A
- Authority
- EC
- Ecuador
- Prior art keywords
- insulin
- conjugate
- propharms
- moiety
- connector conjugate
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical group N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 6
- 102000004877 Insulin Human genes 0.000 abstract 3
- 108090001061 Insulin Proteins 0.000 abstract 3
- 229940125396 insulin Drugs 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a un profármaco o una sal del mismo farmacéuticamente aceptable, que comprende un conjugado de insulina-conector D-L, en el que D representa un resto de insulina; y -L es un resto conector que no es biológicamente activo -L1 representado por la fórmula (I), en la que la línea de trazos indica la unión a uno de los grupos amino de la insulina formando un enlace amida. La invención se refiere además a composiciones farmacéuticas que comprenden dichos profármacos así como a su uso como un medicamento para tratar o prevenir enfermedades o trastornos que se pueden tratar mediante la insulina.The present invention relates to a pharmaceutically acceptable prodrug or salt thereof, comprising an insulin-conjugate conjugate D-L, wherein D represents an insulin moiety; and -L is a linker moiety that is not biologically active -L1 represented by formula (I), in which the dashed line indicates the binding to one of the amino groups of insulin forming an amide bond. The invention further relates to pharmaceutical compositions comprising said prodrugs as well as their use as a medicament for treating or preventing diseases or disorders that can be treated by insulin.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09167027 | 2009-07-31 | ||
| EP09174525 | 2009-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP12011632A true ECSP12011632A (en) | 2012-02-29 |
Family
ID=52449854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP12011632 ECSP12011632A (en) | 2009-07-31 | 2012-01-30 | PROPHARMS THAT INCLUDE AN INSULIN-CONNECTOR CONJUGATE |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP12011632A (en) |
-
2012
- 2012-01-30 EC ECSP12011632 patent/ECSP12011632A/en unknown
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