CN118161749B - Wearable multi-point distributed brain stimulation system - Google Patents
Wearable multi-point distributed brain stimulation system Download PDFInfo
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Abstract
Description
技术领域Technical Field
本发明涉及射频通信技术领域,更为具体来说,本发明为一种可穿戴多点分布式脑刺激系统。The present invention relates to the field of radio frequency communication technology, and more specifically, the present invention is a wearable multi-point distributed brain stimulation system.
背景技术Background Art
现在帕金森患者和癫痫患者前期可进行药物治疗,缓解疾病发展及改善患者症状,但是药物长期使用后会面临药效降低,以及产生副作用,当药物选择无效、效果不佳或产生无法忍受的副作用时,可采用深部脑刺激来治疗震颤和其他症状。Currently, Parkinson's disease patients and epilepsy patients can receive early drug treatment to alleviate disease progression and improve patient symptoms. However, long-term use of drugs will lead to reduced efficacy and side effects. When drug options are ineffective, ineffective, or produce intolerable side effects, deep brain stimulation can be used to treat tremors and other symptoms.
植入式刺激器DBS可以提供精确的电刺激,持续激活大脑,但这些植入电极需要复杂的外科手术,成本和复杂性可能会限制患者的采用。植入式刺激器由电池供电的植入式脉冲发生器组成,该发生器通过电线连接到刺激部位。例如:中国发明专利说明书CN104189995B公开了脑深部刺激电极、装置及方法,当发生器植入胸部时,导线必须穿过头部和颈部,据报道,有4%至15%的植入导线频繁移动会导致导线位移和断裂,而且发生器中的电池经过几年使用必须进行更换,会再次使患者进行手术。Implantable stimulators DBS can provide precise electrical stimulation to continuously activate the brain, but these implanted electrodes require complex surgical procedures, and the cost and complexity may limit patient adoption. The implantable stimulator consists of a battery-powered implantable pulse generator that is connected to the stimulation site by wires. For example: Chinese invention patent specification CN104189995B discloses deep brain stimulation electrodes, devices and methods. When the generator is implanted in the chest, the wires must pass through the head and neck. It is reported that 4% to 15% of the implanted wires are frequently moved, causing the wires to move and break, and the batteries in the generator must be replaced after several years of use, which will cause the patient to undergo surgery again.
发明内容Summary of the invention
为解决背景技术中存在的技术问题,本发明创新地提供了一种可穿戴多点分布式脑刺激系统,从分体设计的角度出发,将刺激器本体与控制主机采用分体连接方式,摆脱了传统有线连接的风险与弊端,刺激器本体多点位部署分布式组网,形成多维度脑部刺激。In order to solve the technical problems existing in the background technology, the present invention innovatively provides a wearable multi-point distributed brain stimulation system. From the perspective of split design, the stimulator body and the control host are connected in a split manner, getting rid of the risks and disadvantages of traditional wired connections. The stimulator body is deployed at multiple points in a distributed network to form multi-dimensional brain stimulation.
为实现上述的技术目的,本发明实施例公开了一种可穿戴多点分布式脑刺激系统,包括:To achieve the above technical objectives, the embodiment of the present invention discloses a wearable multi-point distributed brain stimulation system, comprising:
刺激器本体,设置为多个,多个所述刺激器本体按需固定在患者的颅骨的各个点位,每个所述刺激器本体均设有至少一个电极,所述电极与患者大脑表面接触;以及,The stimulator bodies are provided in a plurality, and the plurality of stimulator bodies are fixed at various points of the patient's skull as required, and each of the stimulator bodies is provided with at least one electrode, and the electrode contacts the surface of the patient's brain; and
穿戴设备,佩戴于患者头部,穿戴设备的内侧安装有多个与刺激器本体一一对接的控制主机,每个所述控制主机均采用电磁无线传输的方式为刺激器本体供电,并且每个所述控制主机均采用无线通讯的方式控制对应刺激器本体的电极按需放电执行电刺激。The wearable device is worn on the patient's head. A plurality of control hosts connected one by one with the stimulator body are installed on the inner side of the wearable device. Each of the control hosts uses electromagnetic wireless transmission to power the stimulator body, and each of the control hosts uses wireless communication to control the electrodes of the corresponding stimulator body to discharge on demand and perform electrical stimulation.
进一步的,本发明一种可穿戴多点分布式脑刺激系统,其中所述刺激器本体的上端设有第一磁性线圈,所述控制主机的下端设有第二磁性线圈,所述控制主机与刺激器本体对接后第二磁性线圈将第一磁性线圈覆盖,使第一磁性线圈与第二磁性线圈耦合,从第二磁性线圈向第一磁性线圈传递电能为刺激器本体供电。Furthermore, the present invention provides a wearable multi-point distributed brain stimulation system, wherein a first magnetic coil is provided at the upper end of the stimulator body, and a second magnetic coil is provided at the lower end of the control host. After the control host is docked with the stimulator body, the second magnetic coil covers the first magnetic coil, so that the first magnetic coil is coupled with the second magnetic coil, and electrical energy is transferred from the second magnetic coil to the first magnetic coil to power the stimulator body.
进一步的,本发明一种可穿戴多点分布式脑刺激系统,其中所述第一磁性线圈电性连接有储能电池,所述储能电池用于存储第二磁性线圈向第一磁性线圈传递的电能,所述储能电池还电性连接有第一电源管理电路,所述第一电源管理电路用于为刺激器本体提供所需的工作电压。Furthermore, the present invention provides a wearable multi-point distributed brain stimulation system, wherein the first magnetic coil is electrically connected to an energy storage battery, and the energy storage battery is used to store the electrical energy transmitted from the second magnetic coil to the first magnetic coil. The energy storage battery is also electrically connected to a first power management circuit, and the first power management circuit is used to provide the required operating voltage for the stimulator body.
进一步的,本发明一种可穿戴多点分布式脑刺激系统,其中所述控制主机的下端设有一环形磁铁,所述第二磁性线圈固定于所述环形磁铁的内周壁下端,所述刺激器本体包括一壳体和一上盖,所述壳体的形状为桶状,所述上盖由铁磁性材料制作,所述上盖密封扣合在壳体的开口处,所述第一磁性线圈固定于上盖的内侧壁上。Furthermore, the present invention provides a wearable multi-point distributed brain stimulation system, wherein the lower end of the control host is provided with an annular magnet, the second magnetic coil is fixed to the lower end of the inner circumferential wall of the annular magnet, the stimulator body includes a shell and an upper cover, the shell is barrel-shaped, the upper cover is made of ferromagnetic material, the upper cover is sealed and fastened at the opening of the shell, and the first magnetic coil is fixed to the inner wall of the upper cover.
进一步的,本发明一种可穿戴多点分布式脑刺激系统,其中所述刺激器本体的壳体内还设有电刺激电路、脑电采集电路、脑电放大电路、脑电滤波电路、脑电AD转换电路和第一蓝牙主控电路,所述电刺激电路与电极连接,用于控制电极放电执行电刺激;所述脑电采集电路与电极连接,用于采集脑电信号,所述脑电放大电路与脑电采集电路连接,用于将采集的脑电信号按设定倍率进行放大;所述脑电滤波电路与脑电放大电路连接,用于去除放大后的脑电信号中的工频干扰信号;所述脑电AD转换电路的输入端与脑电滤波电路连接,用于将滤波后的脑电信号由模拟信号转换为数字信号,脑电AD转换电路的输出与第一蓝牙主控电路连接,用于将数字化的脑电信号转送至第一蓝牙主控电路;所述第一蓝牙主控电路通过蓝牙通信协议与控制主机构建通信链路,用于将脑电信号上传至控制主机;所述第一蓝牙主控电路还与电刺激电路连接,用于接收控制主机下发的刺激指令控制与电刺激电路连接的电极放电,所述电刺激电路、脑电采集电路、脑电放大电路、脑电滤波电路、脑电AD转换电路和第一蓝牙主控电路所需的工作电压由第一电源管理电路提供。Furthermore, the present invention provides a wearable multi-point distributed brain stimulation system, wherein the housing of the stimulator body is further provided with an electric stimulation circuit, an EEG acquisition circuit, an EEG amplification circuit, an EEG filtering circuit, an EEG AD conversion circuit and a first Bluetooth main control circuit, wherein the electric stimulation circuit is connected to the electrode to control the electrode discharge to perform electric stimulation; the EEG acquisition circuit is connected to the electrode to acquire EEG signals, the EEG amplification circuit is connected to the EEG acquisition circuit to amplify the acquired EEG signals at a set magnification; the EEG filtering circuit is connected to the EEG amplification circuit to remove the power frequency interference signal in the amplified EEG signal; the input end of the EEG AD conversion circuit is connected to the EEG filtering circuit The device is connected to a first Bluetooth main control circuit for converting the filtered EEG signal from an analog signal to a digital signal. The output of the EEG AD conversion circuit is connected to a first Bluetooth main control circuit for transferring the digitized EEG signal to the first Bluetooth main control circuit. The first Bluetooth main control circuit establishes a communication link with a control host via a Bluetooth communication protocol for uploading the EEG signal to the control host. The first Bluetooth main control circuit is also connected to an electric stimulation circuit for receiving stimulation instructions issued by the control host to control the discharge of electrodes connected to the electric stimulation circuit. The operating voltage required by the electric stimulation circuit, the EEG acquisition circuit, the EEG amplification circuit, the EEG filtering circuit, the EEG AD conversion circuit and the first Bluetooth main control circuit is provided by a first power management circuit.
进一步的,本发明一种可穿戴多点分布式脑刺激系统,其中所述刺激器本体的壳体内由上至下堆叠布置的第一柔性电路板、第二柔性电路板、第三柔性电路板和第四柔性电路板,所述第一蓝牙主控电路印刷在所述第一柔性电路板上,所述脑电AD转换电路印刷在所述第二柔性电路板上,所述脑电采集电路、脑电放大电路和脑电滤波电路印刷在所述第三柔性电路板上,所述电刺激电路印刷在所述第四柔性电路板上,所述第一柔性电路板、第二柔性电路板、第三柔性电路板和第四柔性电路板通过穿层导电柱连接。Furthermore, the present invention provides a wearable multi-point distributed brain stimulation system, wherein a first flexible circuit board, a second flexible circuit board, a third flexible circuit board and a fourth flexible circuit board are stacked from top to bottom in the shell of the stimulator body, the first Bluetooth main control circuit is printed on the first flexible circuit board, the EEG AD conversion circuit is printed on the second flexible circuit board, the EEG acquisition circuit, the EEG amplification circuit and the EEG filtering circuit are printed on the third flexible circuit board, the electrical stimulation circuit is printed on the fourth flexible circuit board, and the first flexible circuit board, the second flexible circuit board, the third flexible circuit board and the fourth flexible circuit board are connected by through-layer conductive columns.
进一步的,本发明一种可穿戴多点分布式脑刺激系统,其中所述电刺激电路第一MOS开关管Q1、第二MOS开关管Q2、第三MOS开关管Q3和第四MOS开关管Q4,所述第一MOS开关管Q1的栅极与第一蓝牙主控电路的第一信号输出端连接,第一MOS开关管Q1的漏极与电极的阳极连接,第一MOS开关管Q1的源极通过耦合电容C1与电极的阴极连接;所述第二MOS开关管Q2的栅极与第一蓝牙主控电路的第二信号输出端连接,第二MOS开关管Q2的漏极通过耦合电容C1与电极的阴极连接;所述第三MOS开关管Q3和第四MOS开关管Q4的栅极均与第一蓝牙主控电路的第三信号输出端连接,第三MOS开关管Q3的漏极与电源连接,第三MOS开关管Q3的源极和第四MOS开关管Q4的漏极均通过罐式电容C2与第二MOS开关管Q2的源极连接,所述第四MOS开关管Q4的源极接地,第一蓝牙主控电路的第一信号输出端、第二信号输出端和第三信号输出端用于输出电平信号。Furthermore, the present invention provides a wearable multi-point distributed brain stimulation system, wherein the electrical stimulation circuit comprises a first MOS switch tube Q1, a second MOS switch tube Q2, a third MOS switch tube Q3 and a fourth MOS switch tube Q4, the gate of the first MOS switch tube Q1 is connected to the first signal output end of the first Bluetooth main control circuit, the drain of the first MOS switch tube Q1 is connected to the anode of the electrode, and the source of the first MOS switch tube Q1 is connected to the cathode of the electrode through a coupling capacitor C1; the gate of the second MOS switch tube Q2 is connected to the second signal output end of the first Bluetooth main control circuit, and ... second MOS switch tube Q1 is connected to the anode of the electrode, and the source of the first MOS switch tube Q1 is connected to the cathode of the electrode through a coupling capacitor C1. The drain of the S switch tube Q2 is connected to the cathode of the electrode through the coupling capacitor C1; the gates of the third MOS switch tube Q3 and the fourth MOS switch tube Q4 are both connected to the third signal output end of the first Bluetooth main control circuit, the drain of the third MOS switch tube Q3 is connected to the power supply, the source of the third MOS switch tube Q3 and the drain of the fourth MOS switch tube Q4 are both connected to the source of the second MOS switch tube Q2 through the tank capacitor C2, the source of the fourth MOS switch tube Q4 is grounded, and the first signal output end, the second signal output end and the third signal output end of the first Bluetooth main control circuit are used to output level signals.
进一步的,本发明一种可穿戴多点分布式脑刺激系统,其中所述电极的阴极和阳极之间并联有电阻R1。Furthermore, the present invention provides a wearable multi-point distributed brain stimulation system, wherein a resistor R1 is connected in parallel between the cathode and anode of the electrode.
进一步的,本发明一种可穿戴多点分布式脑刺激系统,其中所述控制主机内还设有锂电池和第二蓝牙主控电路,所述锂电池与第二磁性线圈电性连接,所述第二蓝牙主控电路通过第二电源管理电路与锂电池电性连接,第二蓝牙主控电路通过蓝牙通信协议与第一蓝牙主控电路构建通信链路。Furthermore, the present invention provides a wearable multi-point distributed brain stimulation system, wherein the control host is also provided with a lithium battery and a second Bluetooth main control circuit, the lithium battery is electrically connected to the second magnetic coil, the second Bluetooth main control circuit is electrically connected to the lithium battery through a second power management circuit, and the second Bluetooth main control circuit establishes a communication link with the first Bluetooth main control circuit through a Bluetooth communication protocol.
进一步的,本发明一种可穿戴多点分布式脑刺激系统,其中所述锂电池还连接有充电电路,所述充电电路设有USB充电接口。Furthermore, the present invention provides a wearable multi-point distributed brain stimulation system, wherein the lithium battery is also connected to a charging circuit, and the charging circuit is provided with a USB charging interface.
本发明与现有技术的区别在于:本发明将多个刺激器本体按需固定在患者的颅骨的各个点位,每个刺激器本体均设有至少一个电极,固定后电极与患者大脑表面接触,利用佩戴于患者头部穿戴设备内侧安装的多个控制主机与刺激器本体一一对接,每个控制主机均采用电磁无线传输的方式为刺激器本体供电,并且每个控制主机均采用无线通讯的方式控制对应刺激器本体的电极按需放电执行电刺激。采用这种设置方式无需在患者体内植入复杂的引线,极大的简化了手术时间,同时可以避免后期风险。可以对刺激器本体进行多点位部署,可根据疾病分布式组网覆盖全脑表面,形成脑网络神经调控,可以对大脑不同区域在不同时间,实现多个点位刺激,提高预后效果。使用时只需将穿戴设备内侧控制主机与刺激器本体对齐,这一过程无需专业医生的亲自操作,患者可以自行在家完成,极大地便利了病患的生活,避免了频繁往返医院所带来的时间和金钱损失,让患者在家就能享受到高质量的医疗服务,节省了患者的宝贵时间,还大大降低了就医成本让患者在舒适的家庭环境中就能享受到安全、高效的大脑监测和治疗服务。The difference between the present invention and the prior art is that the present invention fixes multiple stimulator bodies on demand at various points of the patient's skull, and each stimulator body is provided with at least one electrode. After fixation, the electrode contacts the surface of the patient's brain, and multiple control hosts installed on the inner side of the wearable device worn on the patient's head are connected one by one with the stimulator bodies. Each control host uses electromagnetic wireless transmission to power the stimulator body, and each control host uses wireless communication to control the electrodes of the corresponding stimulator body to discharge and perform electrical stimulation on demand. This setting method does not require the implantation of complex leads in the patient's body, greatly simplifies the operation time, and can avoid later risks. The stimulator body can be deployed at multiple points, and can be distributed networked to cover the entire brain surface according to the disease to form brain network neural regulation. Multiple point stimulation can be achieved in different areas of the brain at different times to improve the prognosis effect. When using, you only need to align the control host on the inside of the wearable device with the stimulator body. This process does not require personal operation by a professional doctor, and the patient can complete it at home. It greatly facilitates the life of the patient and avoids the loss of time and money caused by frequent trips to the hospital. It allows patients to enjoy high-quality medical services at home, saving patients' precious time and greatly reducing medical costs, allowing patients to enjoy safe and efficient brain monitoring and treatment services in a comfortable home environment.
附图说明BRIEF DESCRIPTION OF THE DRAWINGS
图1为本发明一种可穿戴多点分布式脑刺激系统中刺激器本体的结构示意图;FIG1 is a schematic diagram of the structure of a stimulator body in a wearable multi-point distributed brain stimulation system of the present invention;
图2为本发明一种可穿戴多点分布式脑刺激系统中穿戴装备的结构示意图;FIG2 is a schematic diagram of the structure of wearable equipment in a wearable multi-point distributed brain stimulation system of the present invention;
图3为本发明一种可穿戴多点分布式脑刺激系统中控制主机的环形磁铁与刺激器本体对接的结构示意图;FIG3 is a schematic diagram of the structure of the connection between the annular magnet of the control host and the stimulator body in a wearable multi-point distributed brain stimulation system of the present invention;
图4为本发明一种可穿戴多点分布式脑刺激系统中以线架图方式展示的控制主机的环形磁铁与刺激器本体对接的结构示意图;FIG4 is a schematic diagram of the structure of the connection between the annular magnet of the control host and the stimulator body in a wearable multi-point distributed brain stimulation system of the present invention, shown in the form of a wireframe diagram;
图5为在图1基础上隐去刺激器本体外壳后的立体结构示意图;FIG5 is a schematic diagram of the three-dimensional structure of the stimulator without the housing of the stimulator body on the basis of FIG1;
图6为在图5基础上旋转后另一角度的立体结构示意图;FIG6 is a schematic diagram of a three-dimensional structure rotated from another angle based on FIG5;
图7为刺激器本体内第一电源管理电路的电路结构示意图;FIG7 is a schematic diagram of the circuit structure of the first power management circuit in the stimulator body;
图8为刺激器本体的结构框图;FIG8 is a block diagram of the structure of the stimulator body;
图9为刺激器本体内第一蓝牙主控电路的电路结构示意图;FIG9 is a schematic diagram of the circuit structure of the first Bluetooth main control circuit in the stimulator body;
图10为刺激器本体内脑电采集电路的电路结构示意图;FIG10 is a schematic diagram of the circuit structure of the EEG acquisition circuit in the stimulator body;
图11为刺激器本体内脑电滤波电路的电路结构示意图;FIG11 is a schematic diagram of the circuit structure of the EEG filter circuit in the stimulator body;
图12为刺激器本体内脑电放大电路的电路结构示意图;FIG12 is a schematic diagram of the circuit structure of the electroencephalogram amplifying circuit in the stimulator body;
图13为刺激器本体内电刺激电路的电路结构示意图。FIG. 13 is a schematic diagram of the circuit structure of the electrical stimulation circuit in the stimulator body.
具体实施方式DETAILED DESCRIPTION
下面结合说明书附图对本发明的一种可穿戴多点分布式脑刺激系统进行详细的解释和说明。A wearable multi-point distributed brain stimulation system of the present invention is explained and illustrated in detail below in conjunction with the drawings in the specification.
如图1-3所示,本发明实施例公开了一种可穿戴多点分布式脑刺激系统,包括:As shown in FIGS. 1-3 , an embodiment of the present invention discloses a wearable multi-point distributed brain stimulation system, comprising:
刺激器本体1,设置为多个,多个刺激器本体1按需固定在患者的颅骨的各个点位,每个刺激器本体1均设有至少一个电极11,电极11与患者大脑表面接触;以及,The stimulator body 1 is provided in multiple numbers, and the multiple stimulator bodies 1 are fixed at various points of the patient's skull as required, and each stimulator body 1 is provided with at least one electrode 11, and the electrode 11 contacts the surface of the patient's brain; and,
穿戴设备2,佩戴于患者头部,穿戴设备2的内侧安装有多个与刺激器本体1一一对接的控制主机3,每个控制主机3均采用电磁无线传输的方式为刺激器本体1供电,并且每个控制主机3均采用无线通讯的方式控制对应刺激器本体1的电极11按需放电执行电刺激。The wearable device 2 is worn on the patient's head. A plurality of control hosts 3 are installed on the inner side of the wearable device 2, which are connected one by one with the stimulator body 1. Each control host 3 uses electromagnetic wireless transmission to power the stimulator body 1, and each control host 3 uses wireless communication to control the electrode 11 of the corresponding stimulator body 1 to discharge and perform electrical stimulation as needed.
在本实施例中,将多个刺激器本体1按需固定在患者的颅骨的各个点位,每个刺激器本体1均设有至少一个电极11,固定后电极11与患者大脑表面接触,利用佩戴于患者头部穿戴设备2内侧安装的多个控制主机3与刺激器本体1一一对接,穿戴设备2可以为帽子、头盔等头部佩戴设备,每个控制主机3均采用电磁无线传输的方式为刺激器本体1供电,并且每个控制主机3均采用无线通讯的方式控制对应刺激器本体1的电极11按需放电执行电刺激。采用这种设置方式无需在患者体内植入复杂的引线,极大的简化了手术时间,同时可以避免后期风险。可以对刺激器本体1进行多点位部署,可根据疾病分布式组网覆盖全脑表面,形成脑网络神经调控,可以对大脑不同区域在不同时间,实现多个点位刺激,提高预后效果。使用时只需将穿戴设备2内侧控制主机3与刺激器本体1对齐,这一过程无需专业医生的亲自操作,患者可以自行在家完成,极大地便利了病患的生活,避免了频繁往返医院所带来的时间和金钱损失,让患者在家就能享受到高质量的医疗服务,节省了患者的宝贵时间,还大大降低了就医成本让患者在舒适的家庭环境中就能享受到安全、高效的大脑监测和治疗服务。In this embodiment, multiple stimulator bodies 1 are fixed on demand at various points of the patient's skull, and each stimulator body 1 is provided with at least one electrode 11. After fixation, the electrode 11 contacts the surface of the patient's brain, and multiple control hosts 3 installed on the inner side of the patient's head wearable device 2 are connected to the stimulator body 1 one by one. The wearable device 2 can be a head-worn device such as a hat or a helmet. Each control host 3 uses electromagnetic wireless transmission to power the stimulator body 1, and each control host 3 uses wireless communication to control the electrode 11 of the corresponding stimulator body 1 to discharge and perform electrical stimulation on demand. This setting method does not require the implantation of complex leads in the patient's body, greatly simplifies the operation time, and can avoid later risks. The stimulator body 1 can be deployed at multiple points, and can be distributed networked according to the disease to cover the entire brain surface, forming brain network neural regulation, and can achieve multiple point stimulation at different times for different areas of the brain to improve the prognosis effect. When in use, it is only necessary to align the control host 3 on the inside of the wearable device 2 with the stimulator body 1. This process does not require personal operation by a professional doctor, and the patient can complete it at home by himself, which greatly facilitates the life of the patient and avoids the loss of time and money caused by frequent trips to the hospital. It allows patients to enjoy high-quality medical services at home, saves patients' precious time, and greatly reduces the cost of medical treatment, allowing patients to enjoy safe and efficient brain monitoring and treatment services in a comfortable home environment.
如图4、图6并结合图7所示,在本发明一实施例中,提供了控制主机3向刺激器本体1供电的实现方式。更为具体地,该方式具体通过如下结构实现:在刺激器本体1的上端设有第一磁性线圈12,并在控制主机3的下端设有第二磁性线圈31,当控制主机3与刺激器本体1对接后第二磁性线圈31将第一磁性线圈12覆盖,使得第一磁性线圈12与第二磁性线圈31耦合,这种耦合方式充分利用了电磁感应原理,从而实现从第二个磁性线圈向第一个磁性线圈传递电能,为刺激器本体1供电。这种供电方式使得刺激器本体1能够在没有导线连接的情况下获取足够的能量,确保了刺激器本体1的正常工作。As shown in Fig. 4, Fig. 6 and Fig. 7, in one embodiment of the present invention, a method for realizing that the control host 3 supplies power to the stimulator body 1 is provided. More specifically, the method is realized by the following structure: a first magnetic coil 12 is provided at the upper end of the stimulator body 1, and a second magnetic coil 31 is provided at the lower end of the control host 3. When the control host 3 is docked with the stimulator body 1, the second magnetic coil 31 covers the first magnetic coil 12, so that the first magnetic coil 12 is coupled with the second magnetic coil 31. This coupling method makes full use of the principle of electromagnetic induction, thereby realizing the transfer of electric energy from the second magnetic coil to the first magnetic coil, and supplying power to the stimulator body 1. This power supply method enables the stimulator body 1 to obtain sufficient energy without wire connection, thereby ensuring the normal operation of the stimulator body 1.
在电能分配时,第一磁性线圈12电性连接有储能电池13,储能电池13用于存储第二磁性线圈31向第一磁性线圈12传递的电能,为了确保刺激器本体1各元器件的正常工作,储能电池13还可以选用纽扣电池。此外,储能电池13还电性连接有第一电源管理电路14(如图7所示),第一电源管理电路14的主要作用是为刺激器本体1提供所需的工作电压,第一电源管理电路14可以将储能电池13电压转换成刺激器本体1各元器件所需的工作电压,例如3.3V。When distributing electric energy, the first magnetic coil 12 is electrically connected to an energy storage battery 13, and the energy storage battery 13 is used to store the electric energy transmitted from the second magnetic coil 31 to the first magnetic coil 12. In order to ensure the normal operation of the components of the stimulator body 1, the energy storage battery 13 can also be a button battery. In addition, the energy storage battery 13 is also electrically connected to a first power management circuit 14 (as shown in FIG. 7 ). The main function of the first power management circuit 14 is to provide the required working voltage for the stimulator body 1. The first power management circuit 14 can convert the voltage of the energy storage battery 13 into the working voltage required by the components of the stimulator body 1, such as 3.3V.
在本实施例中,利用第一磁性线圈12与第二磁性线圈31耦合的方式实现了对刺激器本体1高效、可靠的供电,并解决了电能分配的问题。可以彻底摆脱传统有线供电方式,并且可以节省手术时的埋线步骤,大幅节省手术时间。In this embodiment, the first magnetic coil 12 and the second magnetic coil 31 are coupled to realize efficient and reliable power supply to the stimulator body 1, and solve the problem of power distribution. It can completely get rid of the traditional wired power supply method, save the wire embedding step during surgery, and greatly save surgery time.
如图4-6所示,在本发明一实施例中,其中控制主机3的下端设有一环形磁铁32,第二磁性线圈31固定于环形磁铁32的内周壁下端,刺激器本体1包括一壳体14和一上盖15,壳体14的形状为桶状,上盖15由铁磁性材料制作,上盖15密封扣合在壳体14的开口处,第一磁性线圈12固定于上盖15的内侧壁上。在实际使用时,穿戴设备2佩戴于患者头部,通过环形磁铁32和上盖15的磁吸作用使得穿戴设备2内的控制主机3与刺激器本体1轻松对接。此时,第二磁性线圈31正好覆盖在第一磁性线圈12的上方,确保了刺激器本体1的稳定供电。刺激器本体1和控制主机3对应设置为多对,因此可以形成多点位磁吸作用,通过多点位的磁吸作用可以有效防止对接后的控制主机3相对于刺激器本体1产生偏移。无需人为对接,可以为患者提供舒适、安全的使用体验。As shown in Fig. 4-6, in one embodiment of the present invention, the lower end of the control host 3 is provided with an annular magnet 32, the second magnetic coil 31 is fixed to the lower end of the inner peripheral wall of the annular magnet 32, the stimulator body 1 includes a shell 14 and an upper cover 15, the shell 14 is in the shape of a barrel, the upper cover 15 is made of ferromagnetic material, the upper cover 15 is sealed and buckled at the opening of the shell 14, and the first magnetic coil 12 is fixed to the inner side wall of the upper cover 15. In actual use, the wearable device 2 is worn on the patient's head, and the control host 3 in the wearable device 2 is easily docked with the stimulator body 1 through the magnetic attraction of the annular magnet 32 and the upper cover 15. At this time, the second magnetic coil 31 just covers the top of the first magnetic coil 12, ensuring the stable power supply of the stimulator body 1. The stimulator body 1 and the control host 3 are correspondingly set to multiple pairs, so that a multi-point magnetic attraction can be formed, and the control host 3 after docking can be effectively prevented from being offset relative to the stimulator body 1 through the magnetic attraction of the multi-point position. No artificial docking is required, and a comfortable and safe use experience can be provided for patients.
如图8至图13所示,在本发明一实施例中,其中刺激器本体1的壳体14内还设有电刺激电路16(如图13所示)、脑电采集电路17(如图10所示)、脑电放大电路18(如图12所示)、脑电滤波电路19(如图11所示)、脑电AD转换电路110和第一蓝牙主控电路111(如图9所示),电刺激电路16与电极11连接,用于控制电极11放电执行电刺激;脑电采集电路17与电极11连接,用于采集脑电信号,脑电放大电路18与脑电采集电路17连接,用于将采集的脑电信号按设定倍率进行放大;脑电滤波电路19与脑电放大电路18连接,用于去除放大后的脑电信号中的工频干扰信号;脑电AD转换电路110的输入端与脑电滤波电路19连接,用于将滤波后的脑电信号由模拟信号转换为数字信号,脑电AD转换电路110的输出与第一蓝牙主控电路111连接,用于将数字化的脑电信号转送至第一蓝牙主控电路111;第一蓝牙主控电路111通过蓝牙通信协议与控制主机3构建通信链路,用于将脑电信号上传至控制主机3;第一蓝牙主控电路111还与电刺激电路16连接,用于接收控制主机3下发的刺激指令控制与电刺激电路16连接的电极11放电,电刺激电路16、脑电采集电路17、脑电放大电路18、脑电滤波电路19、脑电AD转换电路110和第一蓝牙主控电路111所需的工作电压由第一电源管理电路14提供。As shown in Figures 8 to 13, in one embodiment of the present invention, an electric stimulation circuit 16 (as shown in Figure 13), an EEG acquisition circuit 17 (as shown in Figure 10), an EEG amplification circuit 18 (as shown in Figure 12), an EEG filtering circuit 19 (as shown in Figure 11), an EEG AD conversion circuit 110 and a first Bluetooth main control circuit 111 (as shown in Figure 9) are also provided in the shell 14 of the stimulator body 1. The electric stimulation circuit 16 is connected to the electrode 11 to control the discharge of the electrode 11 to perform electric stimulation; the EEG acquisition circuit 17 is connected to the electrode 11 to collect EEG signals; the EEG amplification circuit 18 is connected to the EEG acquisition circuit 17 to amplify the collected EEG signals according to a set magnification; the EEG filtering circuit 19 is connected to the EEG amplification circuit 18 to remove the industrial frequency interference signal in the amplified EEG signals; the EEG AD conversion circuit 11 The input end of 0 is connected to the EEG filter circuit 19, which is used to convert the filtered EEG signal from an analog signal to a digital signal. The output of the EEG AD conversion circuit 110 is connected to the first Bluetooth main control circuit 111, which is used to transfer the digitized EEG signal to the first Bluetooth main control circuit 111; the first Bluetooth main control circuit 111 establishes a communication link with the control host 3 through the Bluetooth communication protocol, which is used to upload the EEG signal to the control host 3; the first Bluetooth main control circuit 111 is also connected to the electric stimulation circuit 16, which is used to receive the stimulation instruction issued by the control host 3 to control the discharge of the electrode 11 connected to the electric stimulation circuit 16, and the working voltage required by the electric stimulation circuit 16, the EEG acquisition circuit 17, the EEG amplification circuit 18, the EEG filter circuit 19, the EEG AD conversion circuit 110 and the first Bluetooth main control circuit 111 is provided by the first power management circuit 14.
在本实施例中,可以自动巡查各个点位的无线刺激器,然后进行组网连接,实时采集脑部的脑电信号,根据脑部的实际情况,实时调整刺激参数。可以利用控制主机3可以将大脑分成不同的区域,并将每个区域分配一个或多个电极11,通过控制主机3下发刺激指令控制对应区域电极11放电,实现对不同脑区的空间维度的可选择调控。也可以通过控制主机3在不同时间点选择激活指定电极11,实现时间多路复用效果,对多个点位进行刺激。还可以通过控制主机3调整各个电极11的刺激频率、强度和波形,实现对同时工作的多个电极11进行精确控制,对不同电极11应用不同刺激参数,进而提高脑部电刺激的精确性,并优化治疗效果。In this embodiment, the wireless stimulators at various points can be automatically inspected, and then networked and connected, and the brain's electroencephalogram signals can be collected in real time, and the stimulation parameters can be adjusted in real time according to the actual situation of the brain. The control host 3 can be used to divide the brain into different areas, and each area can be assigned one or more electrodes 11. The control host 3 sends stimulation instructions to control the discharge of the corresponding regional electrodes 11, so as to realize the optional regulation of the spatial dimensions of different brain areas. It is also possible to select and activate the designated electrodes 11 at different time points by controlling the host 3 to realize the time multiplexing effect and stimulate multiple points. It is also possible to adjust the stimulation frequency, intensity and waveform of each electrode 11 by controlling the host 3, realize accurate control of multiple electrodes 11 working simultaneously, apply different stimulation parameters to different electrodes 11, and thus improve the accuracy of brain electrical stimulation and optimize the therapeutic effect.
如图5、图6并结合图8所示,在本发明一实施例中,其中刺激器本体1的壳体14内由上至下堆叠布置的第一柔性电路板112、第二柔性电路板113、第三柔性电路板114和第四柔性电路板115,第一蓝牙主控电路111印刷在第一柔性电路板112上,脑电AD转换电路110印刷在第二柔性电路板113上,脑电采集电路17、脑电放大电路18和脑电滤波电路19印刷在第三柔性电路板114上,电刺激电路16印刷在第四柔性电路板115上,第一柔性电路板112、第二柔性电路板113、第三柔性电路板114和第四柔性电路板115通过穿层导电柱116连接。As shown in Figures 5 and 6 in combination with Figure 8, in one embodiment of the present invention, a first flexible circuit board 112, a second flexible circuit board 113, a third flexible circuit board 114 and a fourth flexible circuit board 115 are stacked from top to bottom in the shell 14 of the stimulator body 1, the first Bluetooth main control circuit 111 is printed on the first flexible circuit board 112, the EEG AD conversion circuit 110 is printed on the second flexible circuit board 113, the EEG acquisition circuit 17, the EEG amplification circuit 18 and the EEG filtering circuit 19 are printed on the third flexible circuit board 114, the electrical stimulation circuit 16 is printed on the fourth flexible circuit board 115, and the first flexible circuit board 112, the second flexible circuit board 113, the third flexible circuit board 114 and the fourth flexible circuit board 115 are connected by a through-layer conductive column 116.
在本实施例中,刺激器本体1内部各个器件采用堆叠方式布置,可以极大的缩减刺激器本体1的体积,把刺激器本体1的直径控制在15毫米之内,高度控制在10毫米之内,进而可以减小颅骨开孔的大小,并减小伤口,同时也能降低手术操作难度。In this embodiment, the various components inside the stimulator body 1 are arranged in a stacked manner, which can greatly reduce the volume of the stimulator body 1, control the diameter of the stimulator body 1 within 15 mm, and control the height within 10 mm, thereby reducing the size of the skull opening and the wound, while also reducing the difficulty of surgical operation.
如图9并结合图13所示,在本发明一实施例中,其中电刺激电路16第一MOS开关管Q1、第二MOS开关管Q2、第三MOS开关管Q3和第四MOS开关管Q4,第一MOS开关管Q1的栅极与第一蓝牙主控电路111的第一信号输出端连接,第一MOS开关管Q1的漏极与电极11的阳极连接,第一MOS开关管Q1的源极通过耦合电容C1与电极11的阴极连接;第二MOS开关管Q2的栅极与第一蓝牙主控电路111的第二信号输出端连接,第二MOS开关管Q2的漏极通过耦合电容C1与电极11的阴极连接;第三MOS开关管Q3和第四MO S开关管Q4的栅极均与第一蓝牙主控电路111的第三信号输出端连接,第三MOS开关管Q3的漏极与电源连接,第三MOS开关管Q3的源极和第四MOS开关管Q4的漏极均通过罐式电容C2与第二MOS开关管Q2的源极连接,第四MOS开关管Q4的源极接地,第一蓝牙主控电路111的第一信号输出端、第二信号输出端和第三信号输出端用于输出电平信号,电极11的阴极和阳极之间并联有电阻R1。As shown in FIG. 9 and in combination with FIG. 13, in one embodiment of the present invention, the electrical stimulation circuit 16 includes a first MOS switch tube Q1, a second MOS switch tube Q2, a third MOS switch tube Q3 and a fourth MOS switch tube Q4, the gate of the first MOS switch tube Q1 is connected to the first signal output end of the first Bluetooth main control circuit 111, the drain of the first MOS switch tube Q1 is connected to the anode of the electrode 11, and the source of the first MOS switch tube Q1 is connected to the cathode of the electrode 11 through the coupling capacitor C1; the gate of the second MOS switch tube Q2 is connected to the second signal output end of the first Bluetooth main control circuit 111, and the drain of the second MOS switch tube Q2 is connected to the cathode of the electrode 11 through the coupling capacitor C1; the third MOS switch tube Q3 and the fourth MO The gate of the S switch tube Q4 is connected to the third signal output terminal of the first Bluetooth main control circuit 111, the drain of the third MOS switch tube Q3 is connected to the power supply, the source of the third MOS switch tube Q3 and the drain of the fourth MOS switch tube Q4 are connected to the source of the second MOS switch tube Q2 through the tank capacitor C2, the source of the fourth MOS switch tube Q4 is grounded, the first signal output terminal, the second signal output terminal and the third signal output terminal of the first Bluetooth main control circuit 111 are used to output level signals, and a resistor R1 is connected in parallel between the cathode and the anode of the electrode 11.
在本实施例中,第一蓝牙主控电路111的第一信号输出端为图9中的P0.11引脚,第二信号输出端为图9中的P0.12引脚,第三信号输出端为图9中的P0.13引脚,其输出为高电平信号或低电平信号。VDD电压为3V,当刺激器本体1处于激活状态时,第一蓝牙主控电路111的第一信号输出端、第二信号输出端和第三信号输出端均保持低电平,此时第一MOS开关管Q1、第二MOS开关管Q2、第三MOS开关管Q3和第四MOS开关管Q4均处于截止状态,罐式电容C2充电至电压VDD,耦合电容C1通过电阻R1缓慢放电,放电电流经过连接在V+和V-两端的电极11流过人体组织,而不会产生电刺激。第三信号输出端用于决定刺激幅值的大小,更为具体地,如果刺激幅值选定为6V,那么第三信号输出端输出高电平,使第三MOS开关管Q3导通,第四MOS开关管Q4截止,使罐式电容C2的正极与电源负极相连,此时罐式电容C2负极与VDD之间的电压差为6V。如果刺激幅值选定为3V,那么第三信号输出端输出低电平,使得罐式电容C2的正极与电源的正极相连,此时罐式电容C2与VDD之间的电压差为3V。当第二信号输出端变为高电平时,第二MOS开关管Q2导通,使罐式电容C2的负极与耦合电容C1连接,于是刺激器本体1向脑部发出刺激信号,并且施加在电极11V+和V-两端的脉冲信号的前沿电压就等于所选定的3V或者6V电压。在刺激脉冲发送期间,随着罐式电容C2的放电和耦合电容C1的充电,这个电压逐渐衰减。刺激脉冲发送结束时,将所有与刺激相关的信号输出端重新设置为未激活状态。In this embodiment, the first signal output terminal of the first Bluetooth main control circuit 111 is the P0.11 pin in Figure 9, the second signal output terminal is the P0.12 pin in Figure 9, and the third signal output terminal is the P0.13 pin in Figure 9, and the output is a high level signal or a low level signal. The VDD voltage is 3V. When the stimulator body 1 is in an activated state, the first signal output terminal, the second signal output terminal and the third signal output terminal of the first Bluetooth main control circuit 111 all maintain a low level. At this time, the first MOS switch tube Q1, the second MOS switch tube Q2, the third MOS switch tube Q3 and the fourth MOS switch tube Q4 are all in a cut-off state, and the tank capacitor C2 is charged to the voltage VDD, and the coupling capacitor C1 is slowly discharged through the resistor R1. The discharge current flows through the electrodes 11 connected to the V+ and V- ends through the human tissue without generating electrical stimulation. The third signal output terminal is used to determine the magnitude of the stimulation amplitude. More specifically, if the stimulation amplitude is selected as 6V, the third signal output terminal outputs a high level, so that the third MOS switch tube Q3 is turned on, and the fourth MOS switch tube Q4 is turned off, so that the positive electrode of the can capacitor C2 is connected to the negative electrode of the power supply. At this time, the voltage difference between the negative electrode of the can capacitor C2 and VDD is 6V. If the stimulation amplitude is selected as 3V, the third signal output terminal outputs a low level, so that the positive electrode of the can capacitor C2 is connected to the positive electrode of the power supply. At this time, the voltage difference between the can capacitor C2 and VDD is 3V. When the second signal output terminal becomes a high level, the second MOS switch tube Q2 is turned on, so that the negative electrode of the can capacitor C2 is connected to the coupling capacitor C1, so that the stimulator body 1 sends a stimulation signal to the brain, and the leading edge voltage of the pulse signal applied to the two ends of the electrode 11V+ and V- is equal to the selected 3V or 6V voltage. During the transmission of the stimulation pulse, this voltage gradually decays with the discharge of the can capacitor C2 and the charging of the coupling capacitor C1. When the stimulation pulse is sent, all stimulation-related signal outputs are reset to the inactive state.
在本发明一实施例中,控制主机3内还设有锂电池和第二蓝牙主控电路,锂电池与第二磁性线圈31电性连接,第二蓝牙主控电路通过第二电源管理电路与锂电池电性连接,第二蓝牙主控电路通过蓝牙通信协议与第一蓝牙主控电路111构建通信链路。锂电池还连接有充电电路,充电电路设有USB充电接口。In one embodiment of the present invention, a lithium battery and a second Bluetooth main control circuit are also provided in the control host 3, the lithium battery is electrically connected to the second magnetic coil 31, the second Bluetooth main control circuit is electrically connected to the lithium battery through the second power management circuit, and the second Bluetooth main control circuit establishes a communication link with the first Bluetooth main control circuit 111 through the Bluetooth communication protocol. The lithium battery is also connected to a charging circuit, and the charging circuit is provided with a USB charging interface.
在本实施例中,锂电池为控制主机3的电源来源,为控制主机3提供稳定的电力供应,为了提高充电效率和使用的便捷性,锂电池还连接了充电电路。充电电路设有USB充电接口,患者或用户可以使用常见的USB数据线为设备充电,并通过第二磁性线圈31实现无线充电功能。控制主机3内还设有第二蓝牙主控电路。第二蓝牙主控电路通过第二电源管理电路与锂电池电性连接,从而获得稳定的电力供应。此外,第二蓝牙主控电路还通过蓝牙通信协议与第一蓝牙主控电路111构建通信链路。进而共同构成了一个高效、稳定的通信系统。通过这个通信系统,可以轻松实现无线充电、蓝牙通信功能。In this embodiment, the lithium battery is the power source of the control host 3, providing a stable power supply for the control host 3. In order to improve the charging efficiency and convenience of use, the lithium battery is also connected to the charging circuit. The charging circuit is provided with a USB charging interface, and the patient or user can use a common USB data cable to charge the device, and realize the wireless charging function through the second magnetic coil 31. A second Bluetooth main control circuit is also provided in the control host 3. The second Bluetooth main control circuit is electrically connected to the lithium battery through the second power management circuit to obtain a stable power supply. In addition, the second Bluetooth main control circuit also establishes a communication link with the first Bluetooth main control circuit 111 through the Bluetooth communication protocol. And then together constitute an efficient and stable communication system. Through this communication system, wireless charging and Bluetooth communication functions can be easily realized.
在本发明的描述中,需要理解的是,术语“中心”、“纵向”、“横向”、“长度”、“宽度”、“厚度”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”“内”、“外”、“顺时针”、“逆时针”、“轴向”、“径向”、“周向”等指示的方位或位置关系为基于附图所示的方位或位置关系,仅是为了便于描述本发明和简化描述,而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作,因此不能理解为对本发明的限制。In the description of the present invention, it is to be understood that the terms “center”, “longitudinal”, “lateral”, “length”, “width”, “thickness”, “up”, “down”, “front”, “back”, “left”, “right”, “vertical”, “horizontal”, “top”, “bottom”, “inside”, “outside”, “clockwise”, “counterclockwise”, “axial”, “radial”, “circumferential”, etc., indicating orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.
在本发明中,除非另有明确的规定和限定,术语“安装”、“相连”、“连接”、“固定”等术语应做广义理解,例如,可以是固定连接,也可以是可拆卸连接,或成一体;可以是机械连接,也可以是电连接;可以是直接相连,也可以通过中间媒介间接相连,可以是两个元件内部的连通或两个元件的相互作用关系,除非另有明确的限定。对于本领域的普通技术人员而言,可以根据具体情况理解上述术语在本发明中的具体含义。In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.
此外,术语“第一”、“第二”仅用于描述目的,而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此,限定有“第一”、“第二”的特征可以明示或者隐含地包括至少一个该特征。在本发明的描述中,“多个”的含义是至少两个,例如两个,三个等,除非另有明确具体的限定。In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of the present invention, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.
以上所述仅为本发明的较佳实施例而已,并不用以限制本发明,凡在本发明实质内容上所作的任何修改、等同替换和简单改进等,均应包含在本发明的保护范围之内。The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and simple improvements made to the essential contents of the present invention shall be included in the protection scope of the present invention.
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