CN115120499B - Drug release capsules - Google Patents
Drug release capsules Download PDFInfo
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- CN115120499B CN115120499B CN202210741710.4A CN202210741710A CN115120499B CN 115120499 B CN115120499 B CN 115120499B CN 202210741710 A CN202210741710 A CN 202210741710A CN 115120499 B CN115120499 B CN 115120499B
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- releasing
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- 239000003814 drug Substances 0.000 title claims abstract description 399
- 229940079593 drug Drugs 0.000 title claims abstract description 260
- 239000002775 capsule Substances 0.000 title claims abstract description 81
- 230000007246 mechanism Effects 0.000 claims abstract description 37
- 230000009471 action Effects 0.000 claims abstract description 13
- 238000005452 bending Methods 0.000 claims description 130
- 238000012377 drug delivery Methods 0.000 claims description 59
- 238000007906 compression Methods 0.000 claims description 53
- 230000006835 compression Effects 0.000 claims description 50
- 238000010438 heat treatment Methods 0.000 claims description 15
- 230000005489 elastic deformation Effects 0.000 claims description 12
- 238000009434 installation Methods 0.000 claims description 10
- 239000012943 hotmelt Substances 0.000 claims description 9
- 230000001681 protective effect Effects 0.000 claims description 6
- 230000000903 blocking effect Effects 0.000 claims description 5
- 238000004891 communication Methods 0.000 claims description 5
- 238000002844 melting Methods 0.000 claims description 5
- 230000008018 melting Effects 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 230000010355 oscillation Effects 0.000 claims 1
- 238000007789 sealing Methods 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 23
- 230000008569 process Effects 0.000 abstract description 23
- 230000000694 effects Effects 0.000 abstract description 9
- 238000001647 drug administration Methods 0.000 abstract description 5
- 238000007920 subcutaneous administration Methods 0.000 abstract description 3
- 230000003902 lesion Effects 0.000 abstract 1
- 238000010586 diagram Methods 0.000 description 4
- 239000007901 soft capsule Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 238000013270 controlled release Methods 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公开了释药胶囊，包括：形成有内腔的壳体、设置在内腔中的释药弹片和控制机构，壳体具有连通内腔内外的释药口，释药弹片上设置有与释药口相对的释药部；其中，释药弹片具有初始状态和释药状态，在初始状态时，释药弹片的释药部朝背离释药口的方向突伸设置；在释药状态时，释药弹片在控制机构的作用下形变以使释药部朝靠近释药口的方向移动。本发明通过释药弹片的在形变过程中产生的推动力驱动药物从释药口释放出去，方便操控，且通过弹片的方式能够对药物起到弹射作用，使药物在出射的瞬间初速度更大，释药效率更高，并且待释放药物如果为含药微针，药物在释放后能够深入的插到病灶区皮下，使给药效果更好。
The present invention discloses a drug-releasing capsule, comprising: a shell formed with an inner cavity, a drug-releasing shrapnel arranged in the inner cavity, and a control mechanism, wherein the shell has a drug-releasing port connecting the inner and outer cavity, and the drug-releasing shrapnel is provided with a drug-releasing portion opposite to the drug-releasing port; wherein the drug-releasing shrapnel has an initial state and a drug-releasing state, and in the initial state, the drug-releasing portion of the drug-releasing shrapnel is protruded in a direction away from the drug-releasing port; in the drug-releasing state, the drug-releasing shrapnel is deformed under the action of the control mechanism so that the drug-releasing portion moves toward the drug-releasing port. The present invention drives the drug to be released from the drug-releasing port through the driving force generated by the drug-releasing shrapnel during the deformation process, which is convenient for control, and the shrapnel can play a catapulting role on the drug, so that the drug has a greater initial velocity at the moment of ejection, and the drug-releasing efficiency is higher, and if the drug to be released is a drug-containing microneedle, the drug can be deeply inserted into the subcutaneous part of the lesion area after release, so that the drug administration effect is better.
Description
Technical Field
The invention relates to the technical field of medical appliances, in particular to a drug release capsule.
Background
The controlled release of the drug can improve the therapeutic effect of the drug, reduce side effects, and especially for difficult-to-reach digestive tract sections, the capsule administration scheme is more and more concerned, and the drug has the advantages of no damage, no pain, wide coverage, accurate controlled release of the drug and the like.
At present, some designs of medicine releasing capsules are provided, a soft capsule is generally arranged in the capsule, medicines are stored in the soft capsule, meanwhile, the soft capsule is placed in an inner cavity of a shell, pressurized gas is released into the inner cavity in the medicine releasing process to change the air pressure of the inner cavity, and the air pressure of the inner cavity is increased to compress the soft capsule, so that medicine delivery is realized. In the existing scheme, the medicine wrapped in the soft bag is extruded out mainly by controlling the change of the pressure difference between the inside and the outside of the soft bag, and the medicine release efficiency of the medicine release mode is lower.
Disclosure of Invention
The invention aims to provide the drug release capsule which can play a role in ejecting a drug in a mode of an elastic sheet, so that the initial speed of the drug at the moment of emergence is higher, and the drug release efficiency is higher.
The invention provides a medicine release capsule which comprises a shell, a medicine release elastic sheet and a control mechanism, wherein the shell is provided with an inner cavity, the medicine release elastic sheet is arranged in the inner cavity, the shell is provided with a medicine release opening communicated with the inner cavity and the outer cavity, and the medicine release elastic sheet is provided with a medicine release part opposite to the medicine release opening;
The medicine releasing elastic sheet is provided with an initial state and a medicine releasing state, the medicine releasing part of the medicine releasing elastic sheet is arranged in a protruding mode in the direction away from the medicine releasing opening in the initial state, and the medicine releasing elastic sheet deforms under the action of the control mechanism in the medicine releasing state so that the medicine releasing part moves in the direction close to the medicine releasing opening.
Further, the medicine releasing elastic sheet is provided with an elastic sheet body, two ends of the elastic sheet body are respectively fixed on the shell, in an initial state, the elastic sheet body arches towards the direction deviating from the medicine releasing opening and is positioned at a first bending position, in a medicine releasing state, the elastic sheet body arches towards the direction of the medicine releasing opening and is positioned at a second bending position, and the medicine releasing part is arranged on the elastic sheet body.
Further, the shell is provided with a columnar structure and comprises a top wall, a bottom wall and side walls, wherein the top wall and the bottom wall are oppositely arranged along the axial direction of the shell, the side walls are connected with the top wall and the bottom wall, and the medicine release opening is arranged on the side walls of the shell;
The two ends of the elastic sheet body are respectively fixed on the top wall and the side wall, and a gap part is formed between the elastic sheet body and the shell in an initial state.
Further, a mounting part protruding towards the inner cavity is arranged on the side wall of the shell, and the first end of the elastic sheet body is fixed on the mounting part;
The top wall is provided with a top installation part protruding towards the inner cavity, the second end of the elastic sheet body is fixed on the top installation part, and after the elastic sheet body is fixed, the distance between the second end of the elastic sheet body and the plane where the medicine release opening is located is greater than the distance between the first end of the elastic sheet body and the plane where the medicine release opening is located.
Further, in the initial state, the elastic sheet body is provided with a first bending sheet and a second bending sheet, the first bending sheet and the second bending sheet are both bent towards the direction deviating from the drug release opening so as to generate elastic deformation, and the drug release part is arranged at the joint position of the first bending sheet and the second bending sheet.
The other embodiment of the invention also discloses a drug release capsule which comprises a shell with an inner cavity, a drug release elastic sheet and a control mechanism, wherein the drug release elastic sheet and the control mechanism are arranged in the inner cavity, and the shell is provided with a drug release port communicated with the inner and outer parts of the inner cavity;
The medicine release elastic sheet is provided with a first bending sheet which bends towards the direction away from the medicine release opening and generates elastic deformation, and a medicine release part is formed on the first bending sheet at the position opposite to the medicine release opening;
When the medicine is released, the first bending piece resets and swings under the action of the control mechanism so that the medicine releasing part moves towards the direction close to the medicine releasing opening.
Furthermore, the drug release elastic sheet is further provided with a second bending sheet, and in an initial state, the second bending sheet is matched with the first bending sheet to limit the reset swing of the drug release elastic sheet.
Further, in the initial state, the second bending piece bends towards the direction deviating from the drug release opening and generates elastic deformation, the second bending piece and the first bending piece are mutually extruded to form an arch towards the direction deviating from the drug release opening at the joint, and in the drug release state, the second bending piece synchronously resets and swings along with the drug release elastic piece.
Further, the control mechanism comprises a pushing piece and a driving assembly for driving the pushing piece to move, the pushing piece is arranged on one side, away from the drug release opening, of the drug release elastic piece, and the drug release elastic piece is pushed to move and deform in the moving process of the pushing piece.
Further, the driving assembly comprises a compression spring arranged in the inner cavity, the compression spring is provided with a spring fixing end used for fixing the compression spring and an extension end arranged opposite to the spring fixing end, and the pushing piece is fixed on the extension end;
The compression spring has a compressed state in which the compression spring is compressed and accumulates a return force, and an extended state in which the return force accumulated by the compression spring is released and drives the extended end to move in a direction away from the fixed end of the spring.
Further, the control mechanism further includes a compression second bending tab for maintaining the compression spring in a compressed state, the compression second bending tab including a fusible link, and a compression release for heating the fusible link and melting the fusible link, the fusible link cooperating with the expansion end prior to melting to limit movement of the expansion end.
Further, the driving assembly comprises an elastically deformable bin body with a gas cavity and an air inlet channel communicated with the gas cavity, wherein the gas cavity is used for containing pressurized gas, and the elastically deformable bin body is arranged to expand and stretch under the action of the pressurized gas so as to drive the pushing piece to move towards the direction close to the drug release elastic sheet.
Further, a gas storage cavity is formed in the shell, the air inlet channel is communicated with the gas storage cavity, and the driving assembly is further provided with a valve body assembly for controlling the air inlet channel to be conducted or closed.
Further, the valve body assembly includes a hot melt film for blocking the air intake passage and a film heating member for heating the hot melt film.
Further, the moving direction of the pushing piece is perpendicular to the opening direction of the drug release opening, the drug release opening is opened along the radial direction of the drug release capsule, and the pushing piece moves along the axial direction of the drug release capsule.
Further, a plurality of medicine releasing openings are formed in the shell, each medicine releasing opening is provided with a corresponding medicine releasing elastic sheet, the control mechanism simultaneously controls the plurality of medicine releasing elastic sheets, and the plurality of medicine releasing openings are annularly distributed along the circumference of the medicine releasing capsule.
Furthermore, an exit guide part is further arranged on the shell, the exit guide part is arranged in the inner cavity and positioned at the edge of the drug release opening, and a drug outlet channel is formed in the middle of the exit guide part and at the position opposite to the drug release opening.
Furthermore, a gap part for storing a substance to be released is formed between the emergent guide part and the drug release elastic sheet, the drug release capsule is also provided with drug-containing micro-needles arranged in the gap part, part of the drug-containing micro-needles extend into the drug outlet channel, and the drug-containing micro-needles are opposite to the drug release part.
Furthermore, the drug release capsule is also provided with a protective film for blocking the drug release opening, and the protective film is a biocompatible piece.
Further, the drug delivery capsule also has an endoscopic mechanism disposed in the lumen.
The invention has the advantages that the driving force generated in the deformation process of the drug release elastic sheet drives the drug to release from the drug release port, the operation is convenient, the ejection effect on the drug can be realized in the elastic sheet mode, the initial speed of the drug at the emergent moment is higher, the drug release efficiency is higher, and if the drug to be released is a drug-containing microneedle, the drug can be deeply inserted into the subcutaneous of the focus area after being released, so that the drug administration effect is better.
Drawings
Fig. 1 is a schematic structural diagram of a first drug release capsule disclosed in an embodiment of the present invention before drug release;
Fig. 2 is a schematic structural diagram of a first drug delivery capsule according to an embodiment of the present invention during a drug delivery process;
fig. 3 is a schematic diagram illustrating a deformation process of a drug release elastic sheet of a drug release capsule from a first bending position to a second bending position according to an embodiment of the present invention;
fig. 4 is a schematic structural view of a drug delivery capsule according to an embodiment of the present invention provided with a plurality of groups of drug delivery ports;
fig. 5 is a schematic view of an internal loading structure of a drug delivery capsule provided with a plurality of groups of drug delivery ports according to an embodiment of the present invention;
Fig. 6 is a schematic structural diagram of a second drug delivery capsule disclosed in the embodiment of the present invention before drug delivery;
FIG. 7 is a schematic view showing the structure of a valve body assembly in a second drug delivery capsule according to an embodiment of the present invention;
the reference numerals indicate 1-shell, 10-inner cavity, 101-top wall, 102-bottom wall, 103-side wall, 11-drug release port, 12-exit guide part, 120-exit channel, 13-gap space, 14-gas storage cavity, 15-mounting part, 16-top mounting part,
2-A drug release elastic sheet, 21-a first bending sheet, 22-a second bending sheet,
3-Control mechanism, 31-pushing member, 32-driving assembly, 320-gas chamber, 321-compression spring, 3211-spring fixed end, 3212-extension end, 322-compression second bending piece, 323-compression release member, 324-elastically deformable chamber body, 325-gas inlet channel, 326-valve body assembly, 3261-hot melt film, 3262-film heating member, 327-waterproof film,
4-Medicated microneedle, 5-endoscope mechanism,
100-First bending position, 200-second bending position.
Detailed Description
The embodiments described below by referring to the drawings are illustrative only and are not to be construed as limiting the invention.
The embodiment of the invention discloses a drug release capsule, wherein the drug is stored in the drug release capsule, and the drug is stored in the drug release capsule and enters a drug administration area along with the drug release capsule, and is released when reaching the drug administration area, namely a focus area. After entering the focus area, the drug delivery outlet is aligned to the focus, so that the drug is ejected from the drug release capsule and sprayed on the focus, and accurate drug delivery can be realized.
As shown in fig. 1-5, the disclosed capsule comprises a shell 1 with an inner cavity 10, a drug release elastic sheet 2 and a control mechanism 3, wherein the drug release elastic sheet 2 is arranged in the inner cavity 10, the shell 1 is provided with a drug release opening 11 communicated with the inner and outer sides of the inner cavity 10, and the drug release elastic sheet 2 is provided with a drug release part opposite to the drug release opening 11;
The medicine releasing elastic sheet 2 is provided with an initial state and a medicine releasing state, the medicine releasing part of the medicine releasing elastic sheet 2 is arranged in a protruding mode in a direction away from the medicine releasing opening in the initial state, and the medicine releasing elastic sheet 2 deforms under the action of the control mechanism in the medicine releasing state so that the medicine releasing part moves in a direction close to the medicine releasing opening.
In the use state, the drug to be released is placed in the inner cavity, and before the drug release capsule in this embodiment is released, the drug placement position is located on the moving track of the drug release part when moving in the drug release state, and the object to be released is opposite to the position of the drug release port 11. Therefore, in the drug release state, the control mechanism drives the drug release elastic sheet 2 to deform, and in the deformation process of the drug release elastic sheet 2, the drug release part is driven to move towards the drug release opening, and the drug release part drives the drug to release from the drug release opening in the moving process.
According to the embodiment, the medicine is driven to be released from the medicine release opening through the pushing force generated in the deformation process of the medicine release elastic sheet, the operation is convenient, the medicine can be ejected through the elastic sheet, the instantaneous initial speed of the medicine in emergent is higher, the medicine release efficiency is higher, and if the medicine to be released is a medicine-containing microneedle, the medicine can be deeply inserted into the focus area subcutaneous after being released, so that the medicine administration effect is better.
Some drugs, such as macromolecular drugs, can only be injected subcutaneously during use due to the nature of their biochemical components. The macromolecular drugs can be made into a drug-containing microneedle form through a soluble film, then the drug-releasing capsule technology is utilized, and the drugs are injected under the mucosa of the alimentary canal after being ejected through the drug-releasing elastic sheet through oral administration, so that the drugs can be protected from being damaged by enzyme environment and the like in the alimentary canal, the effect similar to subcutaneous injection is achieved, and meanwhile, the compliance of patients is improved.
In this embodiment, the drug release elastic sheet 2 has an elastic sheet body, two ends of the elastic sheet body are respectively fixed on the housing 1, in an initial state, the elastic sheet body arches in a direction away from the drug release opening 11 and is located at a first bending position 100, in a drug release state, the elastic sheet body arches in a direction toward the drug release opening 11 and is located at a second bending position 200, and the drug release portion is disposed on the elastic sheet body.
The control mechanism 3 drives the elastic sheet body to deform and move from the first bending position 100 to the second bending position 200. The medicine releasing part arranged on the elastic sheet body moves towards the direction close to the medicine releasing opening 11 in the moving process of the elastic sheet body, and drives the medicine to be released from the medicine releasing opening 11 in the moving process.
The shell 1 has a columnar structure and comprises a top wall 101, a bottom wall 102 and a side wall 103 which are oppositely arranged along the axial direction of the shell 1, wherein the side wall 103 is connected with the top wall and the bottom wall, and the medicine release opening 11 is arranged on the side wall 103 of the shell 1;
The two ends of the spring body are respectively fixed on the top wall 101 and the side wall 103, and a gap part is formed between the spring body and the housing 1 in an initial state. The clearance space forms a space between the spring body and the side wall 103 of the housing 1, which space can provide a movable space for the spring body when bending towards the second bending position.
Specifically, a mounting portion 15 protruding toward the inner cavity is provided on the side wall 103 of the housing 1, and the first end of the elastic sheet body is fixed on the mounting portion 15;
As shown in fig. 1, the top wall 101 is provided with a top mounting portion 16 protruding toward the inner cavity, the second end of the elastic sheet body is fixed on the top mounting portion 16, and after the elastic sheet body is fixed, the distance L2 between the second end of the elastic sheet body and the plane of the drug release opening 11 is greater than the distance L1 between the first end of the elastic sheet body and the plane of the drug release opening 11.
The installation and fixation of the elastic sheet body can be conveniently realized by arranging the top installation part 16 and the installation part 15, and the installation part 15 and the top installation part 16 protrude from the inner wall of the shell body 1 to the inner cavity, so that the clearance space formed between the elastic sheet body 2 and the shell body 1 after the installation and fixation is large enough, and the shell body 1 is prevented from interfering with the deformation process of the elastic sheet body, and the movement of the elastic sheet body is further influenced.
The mounting portion 15 and the top mounting portion 16 may each be a mounting post or a mounting block provided on an inner sidewall of the housing 1.
Further, in order to better realize ejection release of the drug, in the initial state, the elastic sheet body has a first bending sheet 21 and a second bending sheet 22, the first bending sheet 21 and the second bending sheet 22 are integrally formed, and the first bending portion 21 and the second bending portion 22 may be formed by bending a spring sheet.
The drug release portion is disposed at a joint position of the first bending piece 21 and the second bending piece 22, and the first bending piece 21 and the second bending piece 22 are both bent towards a direction away from the drug release opening 11 to generate elastic deformation, and the first bending piece 21 and the second bending piece 22 are mutually pressed and generate forces that mutually restrict respective elastic deformation and reset.
In this embodiment, the first bending piece 21 and the second bending piece 22 that form the drug release elastic piece 2 in the initial state are both bent and elastically deformed, and elastic force is accumulated on both the first bending piece 21 and the second bending piece 22 in the initial state, and the elastic force can drive the drug release portion at the combined position of the first bending piece 21 and the second bending piece 22 to move toward the drug release opening 11. Thus, when the control mechanism 3 pushes the drug release elastic sheet 2 to deform, the resilience force accumulated on the first bending sheet 21 and the second bending sheet 22 also acts on the drug and drives the drug to release, so that the drug has a sufficiently large initial speed in the initial stage of release, and the drug is more efficient in the release process.
Of course, in another embodiment, the first bending piece 21 and the second bending piece 22 may not generate elastic deformation, that is, the elastic force is not accumulated, the drug release elastic piece 2 is simply an elastic piece arched towards the direction away from the drug release opening, after the elastic piece receives the acting force on the side away from the drug release opening, the elastic piece deforms to make the drug release portion move towards the direction close to the drug release opening 11, and after the elastic piece is pushed, the elastic piece deforms to arch towards the opposite direction, and pushes the drug to be released in the process.
In this embodiment, in order to better achieve the effect on the drug release elastic sheet 2, the control mechanism 3 includes a pushing member 31 and a driving component 32 that drives the pushing member 31 to move, where the pushing member 31 is disposed on a side of the drug release elastic sheet 2 away from the drug release opening 11, and the pushing member 31 pushes the drug release elastic sheet 2 to move and deform in the moving process.
In a specific embodiment, the driving assembly 32 includes a compression spring 321 disposed in the inner cavity, the compression spring 321 having a spring fixing end 3211 for fixing the compression spring 321 and a stretching end 3212 disposed opposite to the spring fixing end 3211, and the pushing member 31 is fixed on the stretching end 3212, where the spring fixing end 3211 is fixed on the housing 1;
The compression spring 321 has a compressed state in which the compression spring 321 is compressed and accumulates a repulsive force, and an extended state. In the extended state, the return force accumulated in the compression spring 321 is released and drives the extension end 3212 to move in a direction away from the spring fixed end 3211.
The compression spring 321 compresses and accumulates the rebound force in advance, and when releasing the medicine, the rebound force accumulated by the compression spring 321 is controlled to release so as to drive the pushing piece 31, and the pushing piece 31 realizes the pushing deformation of the medicine release elastic sheet 2 in the moving process.
For better control of drug release, the control mechanism 3 further has a compression second bending piece 322 and a compression release piece 323, the compression second bending piece 322 being used for controlling the compression spring 321 to be maintained in a compressed state.
The compression second bending piece 322 includes a fusible link, the compression release piece 323 is used for heating the fusible link and fusing the fusible link, the fusible link is matched with the extension end 3212 before fusing to limit the movement of the extension end 3212, and the fusible link has a lower melting point, such as nylon, low melting point metal and the like, and is quickly softened by heating.
When the compression spring 321 is in a compressed state, one end of the fusible link may be connected and fixed with the extension end 3212, and the other end of the fusible link may be fixed on the spring fixed end 3211, or the other end of the fusible link may be directly fixed on the housing 1. The fusible link pulls the stretch end 3212 and the tension of the fusible link on the stretch end 3212 is opposite to the return spring force of the compression spring 321 on the stretch end 3212.
The release of the resilience force accumulated in the compression spring 321 is controlled by simply canceling the pulling force of the fusible link on the extension end 3212. For convenience of handling, this embodiment is realized by heating the fusible link by compressing the release piece 323 to melt the fusible link.
Specifically, the compression release piece 323 includes the heater strip of setting in fusible yarn side and with the fixed electrical control unit is connected to the heater strip, the electrical control unit is used for controlling the heater strip and generates heat, thereby the heater strip heats the fusible yarn and makes the fusible yarn fuse. The electric control unit is arranged in the shell 1, and the release of the resilience force accumulated by the spring can be realized through the cooperation of the heating component and the fuse wire, so that the control can be realized more conveniently.
In another embodiment, in order to better control the fusible link, the fusible link is directly connected and fixed with the compression release piece 323, and the compression release piece 323 is fixed on the shell, so that heat can be directly released to the fusible link in the heating process, and therefore the fusing of the fusible link is achieved. The compression release 323 may be a heater wire or a heater tray.
It will be appreciated that, in order to avoid the fuse being affected by the digestive juice or the like by the associated electronic control unit, the compression spring 321 is further covered with a waterproof film 327, and the waterproof film 327 may be configured to be stretchable, so that the waterproof film 327 also simultaneously expands and stretches during the process of expanding along with the compression spring 321. Of course, in another embodiment, the length of the waterproof membrane 327 is not smaller than the height of the compressed spring after the compressed spring is stretched, so that the compressed spring still has a good waterproof effect after the compressed spring is stretched.
The pushing piece 31 can move along the opening direction of the medicine release opening to push the medicine release elastic sheet 2, in this case, the medicine is actually released under the dual elastic action of the compression spring 321 and the medicine release elastic sheet 2, the resilience force of the compression spring 321 acts on the medicine release elastic sheet 2, and the medicine release elastic sheet 2 deforms again to release the medicine, so that the medicine has a higher initial speed at the moment of release, and the medicine release is better realized.
In this embodiment, the drug release capsule is columnar as a whole, has an axial direction, and has a circular cross section. The moving direction of the pushing member 31 is perpendicular to the opening direction of the drug release opening 11, the drug release opening 11 is opened along the radial direction of the drug release capsule, and the pushing member 31 moves along the axial direction of the drug release capsule.
Correspondingly, the extension direction of the compression spring 321 in the extension process is along the axial direction of the drug release capsule, the embodiment realizes the release of the drug through the cooperation of the compression spring 321 and the drug release elastic sheet 2, and the arrangement of the drug release elastic sheet 2 converts the thrust of the compression spring 321 in the axial direction into the elasticity for releasing the drug along the radial direction, so that the time of the drug in the release process is shorter, the initial speed is higher, and the drug release operation is more conveniently realized.
In this embodiment, the casing 1 is provided with a plurality of drug release openings 11, each drug release opening 11 is provided with a corresponding drug release elastic sheet 2, and the plurality of drug release openings 11 are provided to release drugs from a plurality of positions of the drug release capsule simultaneously, and to release drugs from a plurality of directions.
In order to better control the plurality of drug release shrapnel 2, the pushing member 31 in the control mechanism 3 for driving the deformation of the drug release shrapnel 2 is set to move along the axial direction of the drug release capsule, and the drug release shrapnel 2 is along the radial direction of the drug release capsule when ejecting the drug to release the drug. Therefore, the control mechanism 3 can control the plurality of the drug release elastic sheets 2 to deform and push the drug to release simultaneously.
Further, the drug release openings 11 are arranged in a ring shape along the circumferential direction of the drug release capsule. The medicine release openings 11 are arranged in a ring shape along the circumferential direction of the medicine release capsule, so that the heights of the medicine release openings 11 in the axial direction are consistent, and therefore, when the pushing piece 31 moves in the vertical direction, the medicine release openings can be simultaneously applied to all the medicine release elastic pieces 2, and the medicine release synchronism is realized.
Furthermore, since the drug release ports 11 are provided in the circumferential direction of the drug release capsule, drug release of the drug release capsule in a plurality of directions can be achieved. Can store a plurality of different types of medicines in a medicine release capsule, thereby realizing the release of a plurality of medicines by the medicine release capsule.
Further, in this embodiment, in order to better control the direction of drug release, the housing is further provided with an exit guiding portion 12, where the exit guiding portion 12 is disposed in the inner cavity 10 and located at the edge of the drug release port 11, and a drug outlet channel 120 is formed in the middle of the exit guiding portion 12 and opposite to the drug release port 11.
The exit guide 12 is used for guiding the medicine during the process of being ejected, so as to prevent the medicine from deviating from the medicine release port 11 before exiting the inner cavity 10, and enable the medicine to move along the medicine outlet channel 120 before reaching the medicine release port 11.
In this embodiment, a gap portion for storing the substance to be released is formed between the exit guiding portion 12 and the release elastic sheet 2, the release capsule further has a drug-containing microneedle 4 disposed in the gap portion 13, a portion of the drug-containing microneedle 4 extends in the drug outlet channel 120, and the drug-containing microneedle 4 is opposite to the drug release portion.
In this embodiment, the drug-containing microneedle 4 is used to load the drug, the drug-releasing elastic sheet 2 ejects the drug-containing microneedle 4 from the drug-releasing opening 11, the drug-containing microneedle 4 can be inserted into the skin after being ejected at a relatively high initial speed, the drug-containing microneedle 4 wraps the drug by a layer of soluble film, and the film wrapping the drug after the drug-containing microneedle 4 is injected into the skin is melted, so that the drug administration under the skin is realized.
The drug-containing microneedles 4 are positioned in the gap portion 13 in advance and part of the drug-containing microneedles 4 are positioned in the drug outlet channel 120 in an extending manner, so that the drug-containing microneedles 4 can effectively play a guiding role in the drug release process. It can be understood that the drug-containing microneedle 4 is opposite to the drug release part, so that the drug-containing microneedle can be conveniently ejected by the drug release elastic sheet.
The drug-containing microneedle 4 can also be loaded in the using process, specifically, when in use, a drug-releasing capsule is firstly obtained, then the drug-containing microneedle 4 is loaded in the gap part 13 of the drug-releasing capsule, and after the loading is completed, the drug-releasing capsule is sent into the intestinal tract for releasing.
After the drug-containing microneedle 4 is loaded, the drug release capsule is further provided with a protective film for blocking the drug release port 11, and the protective film is a biocompatible piece. The biocompatible film is covered on the drug release port 11 to effectively protect the drug.
According to the embodiment, the fuse wire is melted by the heating element, the rebound force accumulated by the compression spring is released at the instant when the fuse wire is melted, the compression spring drives the pushing element to move and acts on the medicine release elastic sheet 2 when the compression spring is released, so that the elastic sheet which is originally protruded in the direction away from the medicine release opening 11 deforms and protrudes towards the medicine release opening 11, the medicine release part on the medicine release elastic sheet 2 moves from the position away from the medicine release opening 11 to the medicine release opening 11, the medicine is released in the moving process, and the medicine is ejected under the action of elastic force of the elastic sheet at the instant when the used elastic sheet is reset, so that the medicine has a larger initial speed at the instant of release, and the medicine-containing microneedle can be penetrated into the skin after being emitted from the medicine release capsule, thereby better realizing medicine administration.
In this embodiment, the drug delivery capsule further has an endoscope mechanism 5 disposed in the inner cavity, and the endoscope mechanism 5 can obtain image information outside the drug delivery capsule, thereby achieving drug delivery accurately.
It can be appreciated that the endoscope mechanism 5 includes that the camera module, the power supply unit, the communication module and the control unit that set up in the casing 1, for convenient realization acquire the outer image information of medicine release capsule, the casing 1 sets up to the transparent body, and power supply unit is for camera module, communication module and the control unit supplies power, and communication module is used for establishing the convenient realization with the external control to medicine release capsule, and camera module is used for gathering the outer image information of capsule after getting into the alimentary canal. It should be noted that the specific operation manner of the specific endoscope mechanism 5 is the prior art, and will not be described herein.
In the above embodiment, a compression spring is used as a driving member to move, as shown in fig. 6-7, in another embodiment, the driving assembly 32 includes an elastically deformable chamber body 324 with a gas cavity 320 and an air inlet channel 325 in communication with the gas cavity 320, where the gas cavity 320 is used to accommodate pressurized gas, and the elastically deformable chamber body 324 is configured to expand and stretch under the action of the pressurized gas to drive the driving member 31 to move toward the drug release dome 2. It will be appreciated that the pushing member 31 is secured to the resiliently deformable cartridge body 324, thereby facilitating the pushing of the pushing member 31 when the resiliently deformable cartridge body 324 expands and stretches.
In the above embodiment, the pressurized gas may enter the gas chamber 320 through the gas inlet channel 325, and after entering the gas chamber 320, the pressurized gas may expand the elastically deformable chamber 324, and when the elastically deformable chamber 324 expands, the pushing member 31 is driven to move. Therefore, the movement of the pushing piece 31 can be controlled by controlling the pressurized gas entering the gas cavity 30, and the release of the medicine by the medicine releasing elastic sheet 2 can be conveniently controlled.
The housing 1 has a gas storage chamber 14 formed therein, the gas inlet passage 325 communicates with the gas storage chamber 14, and the driving assembly 32 further has a valve body assembly 326 for controlling the gas inlet passage 325 to be opened or closed. The gas entering the gas chamber 320 can be pre-filled in the gas storage chamber 14 in the housing 1, when the medicine needs to be released, the valve body assembly 326 is controlled to be communicated with the gas inlet channel 325, pressurized gas enters the gas chamber 320 from the gas outlet chamber 14, and then the elastically deformable chamber body 324 is deformed and drives the pushing member 31.
The valve body assembly 326 includes a hot melt film 3261 for blocking the air inlet passage 325 and a film heating member 3262 for heating the hot melt film 3261 for convenience of implementation. The hot melt film 3261 closes the air inlet channel 325 in the initial state, and the hot melt film 3261 is heated and melted by the film heating member 3262 in the drug release state to conduct the air inlet channel 325, so that the pressurized gas can flow from the air outlet chamber 14 into the gas chamber 320.
The invention discloses a drug release capsule as shown in fig. 1, which comprises a shell 1 with an inner cavity 10, a drug release elastic sheet 2 and a control mechanism 3, wherein the drug release elastic sheet 2 is arranged in the inner cavity 10, and the shell 1 is provided with a drug release port 11 communicated with the inner and outer sides of the inner cavity 10;
the drug release elastic sheet 2 has an initial state and a drug release state, in the initial state, the drug release elastic sheet 2 has a first bending sheet 21 bending towards a direction away from the drug release opening 11 and generating elastic deformation, and a drug release part is formed on the first bending sheet 21 opposite to the drug release opening 11;
in the drug release state, the first bending piece 21 resets and swings under the action of the control mechanism 3 to enable the drug release part to move towards the direction approaching the drug release opening 11.
In this embodiment, the elastic force is accumulated by the pre-bending deformation of the first bending piece 21, and the medicine is released by the restoring resilience force of the elastic deformation.
It can be understood that, in order to maintain the elastic deformation of the drug delivery elastic sheet 2 in the initial state, the drug delivery capsule further has a second bending piece 22, and in the initial state, the second bending piece 22 cooperates with the first bending piece 21 to limit the reset swing of the drug delivery elastic sheet 2.
In this embodiment, the second bending piece 22 is a spring piece connected and fixed with the first bending piece 21, in an initial state, the second bending piece 22 bends in a direction away from the drug release opening 11 and generates elastic deformation, the second bending piece 22 and the drug release spring piece 2 are mutually pressed to form an arch at a joint in a direction away from the drug release opening 11, and in a drug release state, the second bending piece 22 synchronously resets and swings along with the first bending piece 21.
The second bending piece 22 and the first bending piece 21 may be integrally formed and bent by a spring piece, a first end of the first bending piece 21 is fixed on the housing 1, and a second end of the first bending piece 21 connected with the second bending piece 22 moves along with the direction of the elastic change direction of the first bending piece 21 away from the drug release port 11 and along with the reset swing of the first bending piece 21 toward the direction close to the drug release port 11. The first end of the second bending piece 22 is fixed on the casing 1, the second end of the second bending piece 22 is connected and fixed with the second end of the first bending piece 21, and the second end of the second bending piece 22 and the second end of the first bending piece 21 can move synchronously due to the fact that the second bending piece 22 is also an elastic piece and can deform along with the deformation of the first bending piece 21.
In the initial state, both the second bending piece 22 and the first bending piece 21 are bent in a direction away from the drug delivery port 11 and elastically deformed, the second bending piece 22 and the first bending piece 21 are pressed against each other to form mutual restriction to avoid the reset swing, and the second bending piece 22 can be regarded as an elastic piece supported on the reset swing path of the first bending piece 21.
In this embodiment, the second bending piece 22 swings synchronously with the first bending piece 21 when the first bending piece 21 resets and swings, and in other embodiments, the second bending piece 22 may avoid the first bending piece 21 when the first bending piece 21 resets and moves, so that the first bending piece 21 is not blocked when resetting and swinging. In this case, the first bending piece 21 and the second bending piece 22 are separated, and the second bending piece 22 is brought into contact with the first bending piece 21 in the initial state so that the second bending piece 22 is supported between the first bending piece 21 and the case 1, and in the drug release state, the second bending piece 22 is separated from the first bending piece 21 and is deviated from the reset movement locus of the first bending piece 21.
It is to be understood that the driving assembly 32 may be configured as in the above embodiment, and will not be described herein. The balance between the first bending piece 21 and the second bending piece is broken under the pushing action of the driving component 32, and after the balance is broken, the first bending piece 21 can reset and swing towards the direction of the drug release opening 11.
The construction, features and effects of the present invention have been described in detail with reference to the embodiments shown in the drawings, but the above description is only a preferred embodiment of the present invention, but the present invention is not limited to the embodiments shown in the drawings, all changes, or modifications to the teachings of the invention, which fall within the meaning and range of equivalents are intended to be embraced therein, are intended to be embraced therein.
Claims (20)
1. The medicine releasing capsule is characterized by comprising a shell with an inner cavity, a medicine releasing elastic sheet and a control mechanism, wherein the medicine releasing elastic sheet is arranged in the inner cavity, the shell is provided with a medicine releasing port communicated with the inner side and the outer side of the inner cavity, and the medicine releasing elastic sheet is provided with a medicine releasing part opposite to the medicine releasing port;
The medicine releasing elastic sheet is provided with an initial state and a medicine releasing state, the medicine releasing part of the medicine releasing elastic sheet is arranged in a protruding mode in the direction away from the medicine releasing opening in the initial state, and the medicine releasing elastic sheet deforms under the action of the control mechanism in the medicine releasing state so that the medicine releasing part moves in the direction close to the medicine releasing opening.
2. The capsule of claim 1, wherein the elastic sheet has an elastic sheet body, two ends of the elastic sheet body are respectively fixed on the shell, the elastic sheet body arches in a direction away from the drug release opening and is positioned at a first bending position in an initial state, and the elastic sheet body arches in a direction toward the drug release opening and is positioned at a second bending position in a drug release state, and the drug release part is arranged on the elastic sheet body.
3. The drug delivery capsule according to claim 2, wherein the housing has a columnar structure and includes a top wall, a bottom wall, and side walls connecting the top wall and the bottom wall, which are oppositely disposed in an axial direction of the housing, and the drug delivery port is provided on the side walls of the housing;
The two ends of the elastic sheet body are respectively fixed on the top wall and the side wall, and a gap part is formed between the elastic sheet body and the shell in an initial state.
4. A drug release capsule according to claim 3, wherein a mounting portion protruding toward the inner cavity is provided on a side wall of the housing, and the first end of the elastic sheet body is fixed on the mounting portion;
The top wall is provided with a top installation part protruding towards the inner cavity, the second end of the elastic sheet body is fixed on the top installation part, and after the elastic sheet body is fixed, the distance between the second end of the elastic sheet body and the plane where the medicine release opening is located is greater than the distance between the first end of the elastic sheet body and the plane where the medicine release opening is located.
5. The drug delivery capsule according to claim 2, wherein the elastic sheet body has a first bending piece and a second bending piece in an initial state, and the first bending piece and the second bending piece are both bent in a direction away from the drug delivery port to generate elastic deformation, and the drug delivery portion is disposed at a position where the first bending piece and the second bending piece are engaged.
6. The medicine releasing capsule is characterized by comprising a shell with an inner cavity, a medicine releasing elastic sheet and a control mechanism, wherein the medicine releasing elastic sheet and the control mechanism are arranged in the inner cavity;
The medicine release elastic sheet is provided with a first bending sheet which bends towards the direction away from the medicine release opening and generates elastic deformation, and a medicine release part is formed on the first bending sheet at the position opposite to the medicine release opening;
When the medicine is released, the first bending piece resets and swings under the action of the control mechanism so that the medicine releasing part moves towards the direction close to the medicine releasing opening.
7. The drug delivery capsule of claim 6, wherein the drug delivery dome further comprises a second curved tab that cooperates with the first curved tab to limit the reset oscillation of the drug delivery dome in an initial state.
8. The drug delivery capsule according to claim 7, wherein in an initial state, the second bending piece is bent in a direction away from the drug delivery opening and elastically deforms, the second bending piece and the first bending piece are mutually pressed to form an arch at a joint in a direction away from the drug delivery opening, and in a drug delivery state, the second bending piece is synchronously reset and swung along with the drug delivery elastic piece.
9. The drug delivery capsule of any one of claims 1 to 8, wherein the control mechanism comprises a pushing member and a driving assembly for driving the pushing member to move, the pushing member is arranged on one side of the drug delivery elastic sheet away from the drug delivery opening, and the drug delivery elastic sheet is pushed to move and deform during the movement of the pushing member.
10. The drug delivery capsule of claim 9, wherein the drive assembly comprises a compression spring disposed in the interior cavity, the compression spring having a spring-securing end for securing the compression spring and an extension end disposed opposite the spring-securing end, the pusher member being secured to the extension end;
The compression spring has a compressed state in which the compression spring is compressed and accumulates a return force, and an extended state in which the return force accumulated by the compression spring is released and drives the extended end to move in a direction away from the fixed end of the spring.
11. The drug delivery capsule of claim 10, wherein the control mechanism further comprises a compressed second bending tab to maintain the compression spring in a compressed state, the compressed second bending tab including a fusible strand, and a compression release to heat the fusible strand and melt the fusible strand, the fusible strand cooperating with the expansion end prior to melting to limit movement of the expansion end.
12. The drug delivery capsule of claim 9, wherein the driving assembly comprises an elastically deformable bin body with a gas cavity and an air inlet channel communicated with the gas cavity, the gas cavity is used for containing pressurized gas, and the elastically deformable bin body is arranged to expand and stretch under the action of the pressurized gas so as to drive the pushing piece to move towards the direction approaching the drug delivery elastic sheet.
13. The drug delivery capsule of claim 12, wherein a gas storage cavity is formed in the housing, the gas inlet channel is in communication with the gas storage cavity, and the drive assembly further comprises a valve body assembly for controlling the gas inlet channel to be turned on or off.
14. The drug delivery capsule of claim 13, wherein the valve body assembly comprises a hot melt film for blocking the air inlet passage and a film heating member for heating the hot melt film.
15. The drug delivery capsule of claim 9, wherein the pushing member moves in a direction perpendicular to the opening direction of the drug delivery port, the drug delivery port opens in the radial direction of the drug delivery capsule, and the pushing member moves in the axial direction of the drug delivery capsule.
16. The drug release capsule of claim 15, wherein a plurality of drug release openings are formed in the shell, each drug release opening is provided with a corresponding drug release elastic sheet, the control mechanism simultaneously controls the plurality of drug release elastic sheets, and the plurality of drug release openings are annularly arranged along the circumferential direction of the drug release capsule.
17. The drug delivery capsule according to any one of claims 1 to 8, wherein an exit guide portion is further provided on the housing, the exit guide portion is disposed in the inner cavity and located at an edge of the drug delivery port, and a drug delivery channel is formed in a position opposite to the drug delivery port in the middle of the exit guide portion.
18. The drug delivery capsule of claim 17, wherein a gap portion for storing a substance to be released is formed between the exit guide portion and the drug delivery elastic sheet, the drug delivery capsule further has drug-containing microneedles disposed in the gap portion, a portion of the drug-containing microneedles extends in the drug-delivery channel, and the drug-containing microneedles are located opposite to the drug-delivery site.
19. The drug delivery capsule of claim 18, further comprising a protective membrane for sealing the drug delivery port, the protective membrane being a biocompatible member.
20. The drug delivery capsule of any one of claims 1 to 8, further having an endoscopic mechanism disposed in the lumen.
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| CN202210741710.4A CN115120499B (en) | 2022-06-27 | 2022-06-27 | Drug release capsules |
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| CN202210741710.4A CN115120499B (en) | 2022-06-27 | 2022-06-27 | Drug release capsules |
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| CN109171618A (en) * | 2018-10-31 | 2019-01-11 | 自贡德西玛医疗设备有限公司 | A kind of capsule endoscopic of releasable medicaments |
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| WO2005067783A1 (en) * | 2004-01-19 | 2005-07-28 | Olympus Corporation | Imaging device for endoscope and capsule type endoscope |
| JP2008079671A (en) * | 2006-09-26 | 2008-04-10 | Matsushita Electric Works Ltd | Capsule camera |
| JP5251819B2 (en) * | 2009-10-09 | 2013-07-31 | 住友電装株式会社 | Female terminal bracket |
| CN111685715B (en) * | 2020-06-13 | 2021-10-19 | 西安交通大学 | A kind of visualization alimentary tract sampling drug release capsule |
| CN111700648B (en) * | 2020-07-17 | 2025-04-29 | 上海安翰医疗技术有限公司 | Liquid collection capsule, liquid collection system and capsule liquid collection method |
| CN111956940A (en) * | 2020-08-15 | 2020-11-20 | 潍坊医学院附属医院 | Disposable esophagus applicator for digestive system department |
| CN113558827B (en) * | 2021-08-27 | 2024-11-05 | 宁波健世科技股份有限公司 | A device for controlling the release of an implanted device |
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| CN109171618A (en) * | 2018-10-31 | 2019-01-11 | 自贡德西玛医疗设备有限公司 | A kind of capsule endoscopic of releasable medicaments |
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