CN114795253A - A method and system for monitoring uterine contractions based on multi-dimensional information fusion - Google Patents
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Abstract
Description
技术领域technical field
本发明涉及宫缩监测技术领域,尤其涉及一种基于多维度信息融合的宫缩监测方法和系统。The invention relates to the technical field of uterine contraction monitoring, in particular to a uterine contraction monitoring method and system based on multi-dimensional information fusion.
背景技术Background technique
宫缩即子宫有规律地收缩,是临床上孕妇产检的一项重要监测指标。通过放置在孕妇腹部的电极可采集到孕妇宫缩过程中的子宫肌电信号(electrohysterogram,EHG),但是该信号会受到孕妇心电信号(Maternal Eletrocardiogram,MECG)、传感器运动伪迹等噪声干扰的影响,在动态监测过程中,同时会受到孕妇动作产生的肌电信号的干扰,难以有效对宫缩运动进行监测。Uterine contractions are the regular contractions of the uterus, which are an important monitoring index in the clinical obstetric examination of pregnant women. Electrohysterogram (EHG) during pregnancy can be collected through electrodes placed on the abdomen of pregnant women, but this signal will be disturbed by noises such as Maternal Eletrocardiogram (MECG) and sensor motion artifacts. Influence, in the process of dynamic monitoring, at the same time, it will be interfered by the electromyographic signal generated by the movements of pregnant women, so it is difficult to effectively monitor the uterine contractions.
现有的宫缩监测方法是使用三轴加速度传感器配合RMS算法进行监测。RMS算法是目前最常用的提取子宫肌电信号的方法之一,其原理是通过计算子宫肌电的标准差来反映整个EHG信号爆发段和非爆发段信号的能量变化趋势。该方法虽然能够得到较为平滑的EHG波形,有助于宫缩波的识别,但是容易受到传感器运动伪迹的干扰,从而影响宫缩运动的监测效果,且三轴加速度传感器无法在动态情况下得到体位信号信息,难以解决受到孕妇动作产生的肌电信号的干扰的问题。The existing method for monitoring uterine contractions is to use a triaxial acceleration sensor with an RMS algorithm for monitoring. The RMS algorithm is one of the most commonly used methods for extracting uterine EMG signals. Its principle is to reflect the energy change trend of the burst and non-burst EHG signals of the entire EHG signal by calculating the standard deviation of the uterine EMG. Although this method can obtain a relatively smooth EHG waveform, which is helpful for the identification of uterine contraction waves, it is easily interfered by the motion artifact of the sensor, which affects the monitoring effect of uterine contraction movement, and the three-axis acceleration sensor cannot be obtained under dynamic conditions. Body position signal information, it is difficult to solve the problem of interference by the electromyographic signals generated by the movements of pregnant women.
在当前的宫缩运动监测技术中,如何抑制子宫肌电信号的噪声干扰和在静态环境和动态环境下均可有效监测宫缩运动,仍是本领域技术人员亟待解决的技术问题。In the current uterine contraction movement monitoring technology, how to suppress the noise interference of the uterine EMG signal and effectively monitor the uterine contraction movement in a static environment and a dynamic environment is still a technical problem to be solved urgently by those skilled in the art.
发明内容SUMMARY OF THE INVENTION
本发明提供了一基于多维度信息融合的宫缩监测方法和系统,用于解决现有的宫缩运动监测方法难以做到抑制子宫肌电信号的噪声干扰和在静态环境和动态环境下均可有效监测宫缩运动的技术问题。The invention provides a uterine contraction monitoring method and system based on multi-dimensional information fusion, which is used to solve the problem that the existing uterine contraction movement monitoring method is difficult to suppress the noise interference of the uterine EMG signal and can be used in both static and dynamic environments. Technical aspects of effective monitoring of uterine contractions.
有鉴于此,本发明第一方面提供了一种基于多维度信息融合的宫缩监测方法,包括:In view of this, a first aspect of the present invention provides a method for monitoring uterine contractions based on multi-dimensional information fusion, including:
将通过六轴传感器获得的孕妇腹部的三轴加速度信号和三轴角速度信号进行信息融合,得到三轴线性加速度信号;The information fusion of the three-axis acceleration signal and the three-axis angular velocity signal of the pregnant woman's abdomen obtained by the six-axis sensor is performed to obtain the three-axis linear acceleration signal;
对三轴线性加速度信号的宫缩特征段进行标记,确定宫缩时间点集合;Mark the uterine contraction characteristic segment of the three-axis linear acceleration signal, and determine the set of uterine contraction time points;
根据三轴线性加速度信号和宫缩时间点集合构造宫缩运动曲线;Construct the contraction motion curve according to the triaxial linear acceleration signal and contraction time point set;
对获取到的孕妇腹部的混合生物电信号进行MECG信号分离,得到中间态信号;Perform MECG signal separation on the obtained mixed bioelectrical signals of the abdomen of pregnant women to obtain intermediate state signals;
对中间态信号进行EHG特征信号段标记,并根据标记的EHG特征信号段绘制EHG曲线;Mark the EHG characteristic signal segment for the intermediate state signal, and draw the EHG curve according to the marked EHG characteristic signal segment;
将宫缩运动曲线和EHG曲线进行曲线拟合,生成目标宫缩曲线。Curve fitting was performed on the contraction motion curve and the EHG curve to generate the target contraction curve.
可选地,目标宫缩曲线为:Optionally, the target contraction curve is:
其中,CTOCO为目标宫缩曲线,CEHG为EHG曲线,V为表征EHG信号强度的列向量,CACC为宫缩运动曲线,δ为宫缩时静止状态下腹部表面皮肤相对于躯干位移变化的最大值。Among them, C TOCO is the target contraction curve, C EHG is the EHG curve, V is the column vector representing the intensity of the EHG signal, C ACC is the contraction motion curve, and δ is the displacement change of the abdominal surface skin relative to the trunk in the resting state during contractions the maximum value of .
可选地,对三轴线性加速度信号的宫缩特征段进行标记,确定宫缩时间点,包括:Optionally, marking the uterine contraction characteristic segment of the three-axis linear acceleration signal to determine the uterine contraction time point, including:
对三轴线性加速度信号中满足预置约束条件的信号段标记为宫缩特征段;The signal segment that satisfies the preset constraint conditions in the three-axis linear acceleration signal is marked as the uterine contraction feature segment;
其中,预置约束条件为:Among them, the preset constraints are:
其中,t∈T,T为满足的时间点集合,m为T中的元素个数,vmin为最小宫缩速度,tmin为最短宫缩时间,tmax为最长宫缩时间,为三轴线性加速度,为宫缩强度,δ为宫缩时静止状态下腹部表面皮肤相对于躯干位移变化的最大值;Among them, t∈T, T is satisfying set of time points, m is the number of elements in T, v min is the minimum contraction speed, t min is the shortest contraction time, t max is the longest contraction time, is the three-axis linear acceleration, is the contraction intensity, and δ is the maximum displacement change of the abdominal surface skin relative to the trunk in the resting state during contractions;
获取宫缩特征段对应的宫缩时间点集合。Obtain the contraction time point set corresponding to the contraction feature segment.
可选地,宫缩运动曲线为:Optionally, the contraction motion curve is:
其中,CACC为宫缩运动曲线,Tα为由宫缩时间点构成的宫缩时间点集合,Tα∈T。Among them, C ACC is the contraction motion curve, T α is the contraction time point set composed of uterine contraction time points, and T α ∈T.
可选地,最小宫缩速度为0.1m/s,宫缩时静止状态下腹部表面皮肤相对于躯干位移变化的最大值为0.04m,最短宫缩时间为20s,最长宫缩时间为180s。Optionally, the minimum uterine contraction speed is 0.1 m/s, the maximum displacement change of the abdominal surface skin relative to the trunk in a resting state during uterine contractions is 0.04 m, the shortest uterine contraction time is 20s, and the longest uterine contraction time is 180s.
可选地,对获取到的孕妇腹部的混合生物电信号进行MECG信号分离,得到中间态信号,包括:Optionally, MECG signal separation is performed on the obtained mixed bioelectrical signals of the abdomen of pregnant women to obtain intermediate state signals, including:
获取孕妇腹部的混合生物电信号S;Obtain the mixed bioelectric signal S of the abdomen of the pregnant woman;
采用Pan&Tompkins算法检测混合生物电信号S中的MECG的R波位点;The R-wave site of MECG in the mixed bioelectrical signal S was detected by the Pan & Tompkins algorithm;
标记R波位点和对应的信号强度,生成单个的QRS波形;Mark the R wave site and the corresponding signal intensity to generate a single QRS waveform;
将混合生物电信号S与生成的单个的QRS波形在整个时间段上线性相减,得到中间态信号Sf。The mixed bioelectric signal S and the generated single QRS waveform are linearly subtracted over the entire time period to obtain the intermediate state signal S f .
可选地,标记R波位点和对应的信号强度,生成单个的QRS波形,包括:Optionally, mark R-wave sites and corresponding signal intensities to generate a single QRS waveform, including:
标记R波位点;mark the R wave site;
以R波位点为中心分别向左偏移预置数量个采样点和向右偏移预置数量个采样点确定QRS波采样点,根据QRS波采样点和QRS波采样点对应的信号强度构建QRS矩阵;Taking the R wave point as the center, offset the preset number of sampling points to the left and the preset number of sampling points to the right to determine the QRS wave sampling point, and construct the QRS wave sampling point according to the signal intensity corresponding to the QRS wave sampling point and the QRS wave sampling point. QRS matrix;
对QRS矩阵进行奇异值分解,得到QRS波模板矩阵;Perform singular value decomposition on the QRS matrix to obtain the QRS wave template matrix;
提取QRS波模板矩阵的列向量,得到单个的QRS波形。Extract the column vector of the QRS template matrix to obtain a single QRS waveform.
可选地,对中间态信号进行EHG特征信号段标记,并根据标记的EHG特征信号段绘制EHG曲线,包括:Optionally, mark the EHG characteristic signal segment on the intermediate state signal, and draw an EHG curve according to the marked EHG characteristic signal segment, including:
使用预置长度的汉宁窗口对中间态信号Sf进行短时傅里叶变换,得到复数信号矩阵,复数信号矩阵中的列向量为各个频率的信号强度;Use the Hanning window of preset length to perform short-time Fourier transform on the intermediate state signal S f to obtain a complex signal matrix, and the column vector in the complex signal matrix is the signal strength of each frequency;
从复数信号矩阵中取出EHG特征频率处的元素合集Cf;Extract the element set C f at the EHG eigenfrequency from the complex signal matrix;
将EHG特征频率处的元素合集Cf与对应的EHG频率特征阈值相减,得到特征频率矩阵W;The eigenfrequency matrix W is obtained by subtracting the element set C f at the EHG eigenfrequency and the corresponding EHG frequency eigenvalue threshold;
对特征频率矩阵W中的每一行的元素求和,得到表征EHG信号强度的列向量V,n为采样点总数;The elements of each row in the eigenfrequency matrix W are summed to obtain a column vector V representing the strength of the EHG signal, n is the total number of sampling points;
取列向量V中元素大于0且连续时间大于tmin小于tmax的下标集合为I,I为标记为EHG特征信号段的采样点的集合;Take the set of subscripts whose elements in the column vector V are greater than 0 and whose continuous time is greater than t min and less than t max as I, where I is the set of sampling points marked as the EHG feature signal segment;
绘制EHG曲线,EHG曲线为:Plot the EHG curve, the EHG curve is:
其中,i的取值为[1,n]。Among them, the value of i is [1,n].
可选地,EHG特征频率取2个或3个或4个或5个。Optionally, 2 or 3 or 4 or 5 EHG eigenfrequencies are selected.
本发明第二方面提供了一种基于多维度信息融合的宫缩监测系统,包括:A second aspect of the present invention provides a uterine contraction monitoring system based on multi-dimensional information fusion, including:
线性加速度获取模块,用于将通过六轴传感器获得的孕妇腹部的三轴加速度信号和三轴角速度信号进行信息融合,得到三轴线性加速度信号;The linear acceleration acquisition module is used for information fusion of the three-axis acceleration signal and the three-axis angular velocity signal of the pregnant woman's abdomen obtained by the six-axis sensor to obtain the three-axis linear acceleration signal;
宫缩特征标记模块,用于对三轴线性加速度信号的宫缩特征段进行标记,确定宫缩时间点集合;The uterine contraction feature marking module is used to mark the uterine contraction feature segment of the three-axis linear acceleration signal, and determine the set of uterine contraction time points;
宫缩运动曲线模块,用于根据三轴线性加速度信号和宫缩时间点集合构造宫缩运动曲线;The contraction movement curve module is used to construct the contraction movement curve according to the three-axis linear acceleration signal and the contraction time point set;
MECG信号分离模块,用于对获取到的孕妇腹部的混合生物电信号进行MECG信号分离,得到中间态信号;The MECG signal separation module is used to separate the MECG signal from the obtained mixed bioelectrical signal of the abdomen of the pregnant woman to obtain an intermediate state signal;
EHG曲线模块,用于对中间态信号进行EHG特征信号段标记,并根据标记的EHG特征信号段绘制EHG曲线;The EHG curve module is used to mark the EHG characteristic signal segment of the intermediate state signal, and draw the EHG curve according to the marked EHG characteristic signal segment;
宫缩曲线模块,用于将宫缩运动曲线和EHG曲线进行曲线拟合,生成目标宫缩曲线。从以上技术方案可以看出,本发明提供的基于多维度信息融合的宫缩监测方法和系统具有以下优点:The contraction curve module is used to perform curve fitting on the contraction motion curve and the EHG curve to generate the target contraction curve. As can be seen from the above technical solutions, the method and system for monitoring uterine contractions based on multi-dimensional information fusion provided by the present invention have the following advantages:
本发明提供的基于多维度信息融合的宫缩监测方法和系统,一方面利用六轴传感器分析宫缩过程中孕妇腹部的运动状态,绘制宫缩运动曲线,可以避免因孕妇动作发生的重力加速度干扰和不同姿态对于子宫肌电信号特征提取的干扰,在动态环境下同样可检测到宫缩运动,增加了监测宫缩的维度,有效拓展了使用场景,另一方面对混合生物电信号先进行MECG信号分离,然后再进行EHG特征信号段标记,提取出EHG信号,可有效抑制MECG信号的干扰和传感器的运动伪迹带来的干扰,解决了现有的宫缩运动监测方法难以做到抑制子宫肌电信号的噪声干扰和在静态环境和动态环境下均可有效监测宫缩运动的技术问题。The method and system for monitoring uterine contractions based on multi-dimensional information fusion provided by the present invention, on the one hand, utilizes a six-axis sensor to analyze the motion state of the abdomen of the pregnant woman during the uterine contraction, and draws the motion curve of the uterine contraction, which can avoid the interference of gravitational acceleration due to the movement of the pregnant woman And the interference of different postures on the feature extraction of uterine EMG signals, uterine contractions can also be detected in a dynamic environment, which increases the dimension of monitoring uterine contractions and effectively expands the usage scenarios. On the other hand, MECG is first performed on mixed bioelectric signals Signal separation, and then marking the EHG characteristic signal segment to extract the EHG signal, which can effectively suppress the interference of the MECG signal and the interference caused by the motion artifact of the sensor, and solve the problem that the existing uterine contraction motion monitoring method is difficult to suppress the uterus. The noise interference of EMG signals and the technical problems of effective monitoring of uterine contractions in both static and dynamic environments.
附图说明Description of drawings
为了更清楚的说明本发明实施例或现有技术中的技术方案,下面将对实施例或现有技术描述中所需要使用的附图作简单的介绍,显而易见地,下面描述中的附图仅仅是本发明的一些实施例,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据这些附图获得其他相关的附图。In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings that are required to be used in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only These are some embodiments of the present invention. For those of ordinary skill in the art, other related drawings can also be obtained according to these drawings without creative efforts.
图1为本发明中提供的一种基于多维度信息融合的宫缩监测方法的流程示意图;1 is a schematic flowchart of a method for monitoring uterine contractions based on multi-dimensional information fusion provided in the present invention;
图2为本发明中提供的一种基于多维度信息融合的宫缩监测系统的结构示意图。FIG. 2 is a schematic structural diagram of a uterine contraction monitoring system based on multi-dimensional information fusion provided in the present invention.
具体实施方式Detailed ways
为了使本技术领域的人员更好地理解本发明方案,下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。In order to make those skilled in the art better understand the solutions of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only These are some embodiments of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.
为了便于理解,请参阅图1,本发明中提供了一种基于多维度信息融合的宫缩监测方法的实施例,包括:For ease of understanding, please refer to FIG. 1, an embodiment of a method for monitoring uterine contractions based on multi-dimensional information fusion is provided in the present invention, including:
步骤101、将通过六轴传感器获得的孕妇腹部的三轴加速度信号和三轴角速度信号进行信息融合,得到三轴线性加速度信号。Step 101: Perform information fusion on the triaxial acceleration signal of the pregnant woman's abdomen obtained by the six-axis sensor and the triaxial angular velocity signal to obtain a triaxial linear acceleration signal.
需要说明的是,本申请实施例中,六轴传感器包括加速度传感器和陀螺仪传感器,通过加速度传感器获得三轴加速度信号,通过陀螺仪传感器获得三轴角速度信号。将三轴加速度信号和三轴角速度信号融合后得到欧拉角数据为其中,p、r、y分别对应俯仰角、翻滚角和偏航角。在此姿态下,重力加速度作用在加速度传感器上的分量为g为重力加速度。将加速度传感器测得的三轴加速度信号减去得到三轴线性加速度信号即排除了重力加速度干扰的三轴加速度。It should be noted that, in the embodiment of the present application, the six-axis sensor includes an acceleration sensor and a gyro sensor, the three-axis acceleration signal is obtained through the acceleration sensor, and the three-axis angular velocity signal is obtained through the gyro sensor. After fusing the three-axis acceleration signal and the three-axis angular velocity signal, the Euler angle data is obtained as Among them, p, r, y correspond to pitch angle, roll angle and yaw angle respectively. In this attitude, the component of gravitational acceleration acting on the acceleration sensor is g is the acceleration of gravity. Subtract the triaxial acceleration signal measured by the accelerometer Get the three-axis linear acceleration signal That is, the three-axis acceleration that excludes the interference of gravitational acceleration.
步骤102、对三轴线性加速度信号的宫缩特征段进行标记,确定宫缩时间点集合。
需要说明的是,宫缩在皮肤表面的主要特征为:(1)宫缩的速度小于最小宫缩速度;(2)孕妇静止状态下腹部皮肤表面相对于躯干的位移大于0小于宫缩时静止状态下腹部表面皮肤相对于躯干位移变化的最大值;(3)单次宫缩的时长大于最短宫缩时间小于最长宫缩时间。满足以上三个条件的运动表现为宫缩强度,标记为宫缩特征段。It should be noted that the main characteristics of uterine contractions on the skin surface are: (1) the speed of uterine contractions is less than the minimum uterine contraction speed; (2) the displacement of the abdominal skin surface relative to the trunk when the pregnant woman is at rest is greater than 0 and less than when the uterine contractions are at rest. The maximum value of the displacement of the abdominal surface skin relative to the trunk in the state; (3) the duration of a single contraction is greater than the shortest contraction time and less than the longest contraction time. The exercise that satisfies the above three conditions is expressed as the contraction intensity, which is marked as the contraction characteristic segment.
转换为数学表达形式则为:Converted to mathematical expression, it is:
其中,t∈T,T为满足的时间点集合,m为T中的元素个数,vmin为最小宫缩速度,tmin为最短宫缩时间,tmax为最长宫缩时间,为三轴线性加速度,为宫缩强度,δ为宫缩时静止状态下腹部表面皮肤相对于躯干位移变化的最大值。Among them, t∈T, T is satisfying set of time points, m is the number of elements in T, v min is the minimum contraction speed, t min is the shortest contraction time, t max is the longest contraction time, is the three-axis linear acceleration, is the contraction intensity, and δ is the maximum displacement change of the abdominal surface skin relative to the trunk in the resting state during contractions.
本发明实施例中最小宫缩速度优选0.1m/s,宫缩时静止状态下腹部表面皮肤相对于躯干位移变化的最大值优选0.04m,最短宫缩时间优选20s,最长宫缩时间优选180s。在算法上,三轴线性加速度表示为:In the embodiment of the present invention, the minimum uterine contraction speed is preferably 0.1m/s, the maximum value of the displacement change of the abdominal surface skin relative to the trunk in a static state during uterine contractions is preferably 0.04m, the shortest uterine contraction time is preferably 20s, and the longest uterine contraction time is preferably 180s . Algorithmically, the three-axis linear acceleration is expressed as:
其中,x、y、z分别表示x轴、y轴、z轴方向的线性加速度。Among them, x, y, and z represent the linear accelerations in the x-axis, y-axis, and z-axis directions, respectively.
以上三个条件可以转换为:The above three conditions can be transformed into:
(1)宫缩强度在时间上的积分<0.1m/s;(1) Strength of contractions Integral over time <0.1m/s;
(2)宫缩强度在时间上从0开始二次积分回到0的时间长度>20s且<180s;(2) Intensity of uterine contractions The time length for the second integration from 0 to return to 0 in time is >20s and <180s;
(3)宫缩强度在时间上的二次积分小于4cm。(3) Strength of contractions The quadratic integral over time is less than 4 cm.
具体的信号处理流程可以描述为:The specific signal processing flow can be described as:
存在一个集合T,t∈T,其中,t为时间,并且使得 There exists a set T, t ∈ T, where t is time such that
则有T={t1,t2,…,tl},l为T中元素的个数,tl为第l个时间点。Then there is T={t 1 ,t 2 ,...,t l }, where l is the number of elements in T, and t l is the lth time point.
存在一个集合Tα,Tα∈T,使得Tα中的元素满足:There exists a set T α , T α ∈ T such that the elements in T α satisfy:
那么,集合Tα={t1α,t2α,…,tkα}中的元素为宫缩时间点,k为Tα中的元素个数。Then, the elements in the set T α ={t 1α ,t 2α ,...,t kα } are the contraction time points, and k is the number of elements in T α .
步骤103、根据三轴线性加速度信号和宫缩时间点集合构造宫缩运动曲线。需要说明的是,宫缩运动曲线CACC可根据三轴线性加速度信号和由宫缩时间点构成的宫缩时间点集合Tα构造出来:
步骤104、对获取到的孕妇腹部的混合生物电信号进行MECG信号分离,得到中间态信号。Step 104: Perform MECG signal separation on the acquired mixed bioelectrical signals of the abdomen of the pregnant woman to obtain an intermediate state signal.
需要说明的是,通过采集电极取得孕妇腹部的混合生物电信号S,从混合生物电信号S中将MECG信号St分离出来,得到减掉了MECG信号St的混合生物电信号,即中间态信号Sf。It should be noted that the mixed bioelectrical signal S of the abdomen of the pregnant woman is obtained by collecting electrodes, and the MECG signal S t is separated from the mixed bioelectrical signal S to obtain the mixed bioelectrical signal minus the MECG signal S t , that is, the intermediate state. signal S f .
具体地,采用Pan&Tompkins算法检测混合生物电信号S中的MECG的R波位点,标记R波位点和对应的信号强度,生成单个的QRS波形,将混合生物电信号S与生成的单个的QRS波形在整个时间段上线性相减,得到中间态信号Sf。信号处理过程为:Specifically, the Pan & Tompkins algorithm is used to detect the R-wave site of MECG in the mixed bioelectrical signal S, mark the R-wave site and the corresponding signal intensity, generate a single QRS waveform, and compare the mixed bioelectrical signal S with the generated single QRS The waveforms are linearly subtracted over the entire time period to obtain the intermediate state signal S f . The signal processing process is:
(1)标记R波。使用模数转换器对混合生物电信号S采样,生成离散时间序列信号,记作:(1) Mark the R wave. The mixed bioelectrical signal S is sampled using an analog-to-digital converter to generate a discrete time series signal, denoted as:
其中,n为采样点总数,采样频率为fs,单位为Hz。Among them, n is the total number of sampling points, the sampling frequency is f s , and the unit is Hz.
使用Pan&Tompkins生成向量:Use Pan & Tompkins to generate vectors:
其中,K为混合生物电信号S中R波的个数,t1~tK为R波波峰的时间点,K<n。Among them, K is the number of R waves in the mixed bioelectric signal S, t 1 to t K are the time points of the R wave peaks, and K<n.
设α为QRS波以R波为中心的左边偏移采样点,β为QRS波以R波为中心的右边偏移采样点,矩阵IA为QRS波的采样点矩阵,IA表示为:Let α be the left offset sampling point of the QRS wave centered on the R wave, β be the right offset sampling point of the QRS wave centered on the R wave, and the matrix I A is the sampling point matrix of the QRS wave, and I A is expressed as:
(2)生成QRS矩阵。根据向量TR生成QRS矩阵AS:(2) Generate the QRS matrix. Generate the QRS matrix A S from the vector TR :
使元素a满足aq=sq,如果q∈IA且q∈{1,2,…,n}。Let element a satisfy a q =s q if q∈IA and q∈{1,2,...,n}.
其中,元素a∈S,AS为大小为(α+β+1)×K的矩阵,AS的单个列向量为单个QRS波的采样信号。Among them, the element a∈S, A S is a matrix of size (α+β+1)×K, and a single column vector of A S is the sampling signal of a single QRS wave.
α和β分别取经验值:α=0.25fs,β=0.45fs。α and β take empirical values respectively: α=0.25f s , β=0.45f s .
(3)构造QRS波模板矩阵。由AS为大小为(α+β+1)×K的矩阵,可以找到UYVT≈AS,U为AS的左奇异值向量,是大小为(α+β+1)×J的矩阵,J为奇异值向量的个数,取经验值为2。Y为AS的奇异值矩阵,大小为J×J,V为AS的右奇异值向量,是大小为K×J的矩阵。(3) Construct QRS template matrix. From A S as a matrix of size (α+β+1)×K, UYV T ≈A S can be found, and U is the left singular value vector of A S , which is a matrix of size (α+β+1)×J , J is the number of singular value vectors, and the empirical value is 2. Y is the singular value matrix of A S , the size is J × J, and V is the right singular value vector of A S , which is a matrix of size K × J.
可以求得:将At中的元素记作b,有:You can get: Denote the element in A t as b, we have:
矩阵At的大小为(α+β+1)×K。The size of the matrix At is (α+β+1)×K.
矩阵At中的列向量对应信号S中孕妇心电QRS波生成的模板,以此模板可以构建向量St:The column vector in the matrix A t corresponds to the template generated by the QRS wave of the pregnant woman's electrocardiogram in the signal S, and the vector S t can be constructed from this template:
(4)将信号S与向量St相减,得到Sf,Sf即为去除了孕妇心电MECG的电信号,可将该信号定义为中间态信号。(4) Subtract the signal S and the vector S t to obtain S f , which is the electrical signal from which the electrocardiogram MECG of the pregnant woman has been removed, which can be defined as an intermediate state signal.
若信号采集含有多个通道,那么可以使用同一个TR和不同通道的S,重复(1)-(4)步骤。If the signal acquisition contains multiple channels, the same TR and S of different channels can be used, and steps (1)-(4) can be repeated.
步骤105、对中间态信号进行EHG特征信号段标记,并根据标记的EHG特征信号段绘制EHG曲线。Step 105: Mark the EHG characteristic signal segment on the intermediate state signal, and draw an EHG curve according to the marked EHG characteristic signal segment.
需要说明的是,去除了孕妇心电MECG的电信号Sf中,主要混有传感器运动伪迹带来的干扰、胎儿心电信号干扰、子宫肌电信号和传感器内部噪声等。子宫肌电信号与其他干扰最简单明显的特征是频率特征。因此可以选择多个频率特征点作为参考点,标记EHG特征信号段。It should be noted that the electrical signal S f of the pregnant woman's ECG MECG is mainly mixed with interference caused by sensor motion artifacts, fetal ECG signal interference, uterine EMG signal, and internal noise of the sensor. The most simple and obvious feature of uterine EMG signal and other interference is the frequency feature. Therefore, multiple frequency characteristic points can be selected as reference points to mark the EHG characteristic signal segment.
具体地,本实施例使用短时傅里叶变换,取出频率特征点大于阈值的信号段,标记为EHG特征信号段。信号处理流程为:Specifically, in this embodiment, the short-time Fourier transform is used to extract the signal segment whose frequency characteristic point is greater than the threshold, and mark it as the EHG characteristic signal segment. The signal processing flow is:
使用预置长度N的汉宁窗口对中间态信号Sf进行短时傅里叶变换,得到复数信号矩阵和频率列向量。Use the Hanning window of preset length N to perform short-time Fourier transform on the intermediate state signal S f to obtain the complex signal matrix and frequency column vector.
复数信号矩阵记作C:The complex signal matrix is denoted by C:
频率列向量记作F:The frequency column vector is denoted F:
其中,频率列向量F为复数信号C对应的频率向量,E为频率个数,满足奈奎斯特定理,n为采用点总数。Among them, the frequency column vector F is the frequency vector corresponding to the complex signal C, E is the number of frequencies, which satisfies the Nyquist theorem, and n is the total number of points used.
从频率列向量中取出预置数量个(优选2个或3个或4个或5个)频率特征点大于频率特征阈值的信号段,记作:Take out a preset number (preferably 2 or 3 or 4 or 5) signal segments whose frequency feature points are greater than the frequency feature threshold from the frequency column vector, and denote it as:
设置频率特征阈值:Set the frequency feature threshold:
得到频率特征阈值矩阵:Get the frequency feature threshold matrix:
找到矩阵C中对应频率特征向量Ff的点求模,得到集合Cf:Find the point in the matrix C corresponding to the frequency eigenvector F f and take the modulus to get the set C f :
将EHG特征信号段的频率特征数值与频率特征阈值相减,得到特征频率矩阵W:The frequency characteristic value of the EHG characteristic signal segment is subtracted from the frequency characteristic threshold to obtain the characteristic frequency matrix W:
对特征频率矩阵W中的每一行的元素求和,得到表征EHG信号强度的列向量V:Summing the elements of each row in the eigenfrequency matrix W yields a column vector V representing the strength of the EHG signal:
其中,V中元素大于零的下标中满足连续个数大于20fs且小于180fs的集合为I,I标记为EHG特征信号段的采样点的集合。Among them, the set of subscripts with elements greater than zero in V satisfying the consecutive number greater than 20f s and less than 180f s is I, and I is marked as the set of sampling points of the EHG feature signal segment.
使用列向量V绘制EHG曲线,在未标记的区域置零。得到EHG曲线为:Use the column vector V to draw the EHG curve, zeroing in the unlabeled regions. The EHG curve is obtained as:
其中,i的取值为[1,n]。Among them, the value of i is [1,n].
需要说明的是,本申请实施例中,步骤101-步骤103可以与步骤104-步骤105同时进行,步骤101-步骤103和步骤104-步骤105之间不存在执行时间先后顺序关系,即可以在执行步骤101-步骤103时同时执行步骤104-步骤105,也可以先执行步骤101-步骤103后执行步骤104-步骤105。It should be noted that, in this embodiment of the present application, steps 101-
步骤106、将宫缩运动曲线和EHG曲线进行曲线拟合,生成目标宫缩曲线。Step 106: Perform curve fitting on the contraction motion curve and the EHG curve to generate a target contraction curve.
需要说明的是,在经过步骤103得到宫缩运动曲线和步骤105得到EHG曲线后,使用线性叠加的方式,将宫缩运动曲线和EHG曲线进行曲线拟合,生成目标宫缩曲线:It should be noted that, after obtaining the uterine contraction motion curve in
其中,CTOCO为目标宫缩曲线,CEHG为EHG曲线,V为表征EHG信号强度的列向量,CACC为宫缩运动曲线,δ为宫缩时静止状态下腹部表面皮肤相对于躯干位移变化的最大值,可取经验值0.04。Among them, C TOCO is the target contraction curve, C EHG is the EHG curve, V is the column vector representing the intensity of the EHG signal, C ACC is the contraction motion curve, and δ is the displacement change of the abdominal surface skin relative to the trunk in the resting state during contractions The maximum value of , and the empirical value is 0.04.
本发明实施例提供的基于多维度信息融合的宫缩监测方法,一方面利用六轴传感器分析宫缩过程中孕妇腹部的运动状态,绘制宫缩运动曲线,可以避免因孕妇动作发生的重力加速度干扰和不同姿态对于子宫肌电信号特征提取的干扰,在动态环境下同样可检测到宫缩运动,增加了监测宫缩的维度,有效拓展了使用场景,另一方面对混合生物电信号先进行MECG信号分离,然后再进行EHG特征信号段标记,提取出EHG信号,可有效抑制MECG信号的干扰和传感器的运动伪迹带来的干扰,解决了现有的宫缩运动监测方法难以做到抑制子宫肌电信号的噪声干扰和在静态环境和动态环境下均可有效监测宫缩运动的技术问题。In the method for monitoring uterine contractions based on multi-dimensional information fusion provided by the embodiments of the present invention, on the one hand, six-axis sensors are used to analyze the motion state of the abdomen of the pregnant woman during the uterine contraction, and the motion curve of the uterine contraction can be drawn, which can avoid the interference of gravitational acceleration due to the movement of the pregnant woman And the interference of different postures on the feature extraction of uterine EMG signals, uterine contractions can also be detected in a dynamic environment, which increases the dimension of monitoring uterine contractions and effectively expands the usage scenarios. On the other hand, MECG is first performed on mixed bioelectric signals Signal separation, and then marking the EHG characteristic signal segment to extract the EHG signal, which can effectively suppress the interference of the MECG signal and the interference caused by the motion artifact of the sensor, and solve the problem that the existing uterine contraction motion monitoring method is difficult to suppress the uterus. The noise interference of EMG signals and the technical problems of effective monitoring of uterine contractions in both static and dynamic environments.
本发明中还提供了一种基于多维度信息融合的宫缩监测系统的实施例,包括:The present invention also provides an embodiment of a uterine contraction monitoring system based on multi-dimensional information fusion, including:
线性加速度获取模块,用于将通过六轴传感器获得的孕妇腹部的三轴加速度信号和三轴角速度信号进行信息融合,得到三轴线性加速度信号;The linear acceleration acquisition module is used for information fusion of the three-axis acceleration signal and the three-axis angular velocity signal of the pregnant woman's abdomen obtained by the six-axis sensor to obtain the three-axis linear acceleration signal;
宫缩特征标记模块,用于对三轴线性加速度信号的宫缩特征段进行标记,确定宫缩时间点集合;The uterine contraction feature marking module is used to mark the uterine contraction feature segment of the three-axis linear acceleration signal, and determine the set of uterine contraction time points;
宫缩运动曲线模块,用于根据三轴线性加速度信号和宫缩时间点集合构造宫缩运动曲线;The contraction movement curve module is used to construct the contraction movement curve according to the three-axis linear acceleration signal and the contraction time point set;
MECG信号分离模块,用于对获取到的孕妇腹部的混合生物电信号进行MECG信号分离,得到中间态信号;The MECG signal separation module is used to separate the MECG signal from the obtained mixed bioelectrical signal of the abdomen of the pregnant woman to obtain an intermediate state signal;
EHG曲线模块,用于对中间态信号进行EHG特征信号段标记,并根据标记的EHG特征信号段绘制EHG曲线;The EHG curve module is used to mark the EHG characteristic signal segment of the intermediate state signal, and draw the EHG curve according to the marked EHG characteristic signal segment;
宫缩曲线模块,用于将宫缩运动曲线和EHG曲线进行曲线拟合,生成目标宫缩曲线。The contraction curve module is used to perform curve fitting on the contraction motion curve and the EHG curve to generate the target contraction curve.
目标宫缩曲线为:The target contraction curve is:
其中,CTOCO为目标宫缩曲线,CEHG为EHG曲线,V为表征EHG信号强度的列向量,CACC为宫缩运动曲线,δ为宫缩时静止状态下腹部表面皮肤相对于躯干位移变化的最大值。Among them, C TOCO is the target contraction curve, C EHG is the EHG curve, V is the column vector representing the intensity of the EHG signal, C ACC is the contraction motion curve, and δ is the displacement change of the abdominal surface skin relative to the trunk in the resting state during contractions the maximum value of .
宫缩特征标记模块具体用于:The contraction signature module is specifically used to:
对三轴线性加速度信号中满足预置约束条件的信号段标记为宫缩特征段;其中,预置约束条件为:The signal segment that satisfies the preset constraint conditions in the three-axis linear acceleration signal is marked as the uterine contraction feature segment; wherein, the preset constraint conditions are:
其中,t∈T,T为满足的时间点集合,m为T中的元素个数,vmin为最小宫缩速度,tmin为最短宫缩时间,tmax为最长宫缩时间,为三轴线性加速度,为宫缩强度,δ为宫缩时静止状态下腹部表面皮肤相对于躯干位移变化的最大值;Among them, t∈T, T is satisfying set of time points, m is the number of elements in T, v min is the minimum contraction speed, t min is the shortest contraction time, t max is the longest contraction time, is the three-axis linear acceleration, is the contraction intensity, and δ is the maximum displacement change of the abdominal surface skin relative to the trunk in the resting state during contractions;
获取宫缩特征段对应的宫缩时间点。Obtain the contraction time point corresponding to the contraction feature segment.
宫缩运动曲线为:The contraction motion curve is:
其中,CACC为宫缩运动曲线,Tα为由宫缩时间点构成的宫缩时间点集合,Tα∈T。Among them, C ACC is the contraction motion curve, T α is the contraction time point set composed of uterine contraction time points, and T α ∈T.
最小宫缩速度为0.1m/s,宫缩时静止状态下腹部表面皮肤相对于躯干位移变化的最大值为0.04m,最短宫缩时间为20s,最长宫缩时间为180s。The minimum uterine contraction speed was 0.1m/s, the maximum displacement of the abdominal surface skin relative to the trunk was 0.04m in the resting state during uterine contractions, the shortest uterine contraction time was 20s, and the longest uterine contraction time was 180s.
对获取到的孕妇腹部的混合生物电信号进行MECG信号分离,得到中间态信号,包括:Perform MECG signal separation on the obtained mixed bioelectrical signals of the abdomen of pregnant women to obtain intermediate state signals, including:
获取孕妇腹部的混合生物电信号S;Obtain the mixed bioelectric signal S of the abdomen of the pregnant woman;
采用Pan&Tompkins算法检测混合生物电信号S中的MECG的R波位点;The R-wave site of MECG in the mixed bioelectrical signal S was detected by the Pan & Tompkins algorithm;
标记R波位点和对应的信号强度,生成单个的QRS波形;Mark the R wave site and the corresponding signal intensity to generate a single QRS waveform;
将混合生物电信号S与生成的单个的QRS波形在整个时间段上线性相减,得到中间态信号Sf。The mixed bioelectric signal S and the generated single QRS waveform are linearly subtracted over the entire time period to obtain the intermediate state signal S f .
标记R波位点和对应的信号强度,生成单个的QRS波形,包括:Mark the R-wave site and the corresponding signal intensity to generate a single QRS waveform, including:
标记R波位点;mark the R wave site;
以R波位点为中心分别向左偏移预置数量个采样点和向右偏移预置数量个采样点确定QRS波采样点,根据QRS波采样点和QRS波采样点对应的信号强度构建QRS矩阵;Taking the R wave point as the center, offset the preset number of sampling points to the left and the preset number of sampling points to the right to determine the QRS wave sampling point, and construct the QRS wave sampling point according to the signal intensity corresponding to the QRS wave sampling point and the QRS wave sampling point. QRS matrix;
对QRS矩阵进行奇异值分解,得到QRS波模板矩阵;Perform singular value decomposition on the QRS matrix to obtain the QRS wave template matrix;
提取QRS波模板矩阵的列向量,得到单个的QRS波形。Extract the column vector of the QRS template matrix to obtain a single QRS waveform.
对中间态信号进行EHG特征信号段标记,并根据标记的EHG特征信号段绘制EHG曲线,包括:Mark the EHG characteristic signal segment for the intermediate state signal, and draw the EHG curve according to the marked EHG characteristic signal segment, including:
使用预置长度的汉宁窗口对中间态信号Sf进行短时傅里叶变换,得到复数信号矩阵复数信号矩阵中的列向量为各个频率的信号强度;Use the Hanning window of preset length to perform short-time Fourier transform on the intermediate state signal S f , and obtain the complex signal matrix The column vector in the complex signal matrix is the signal intensity of each frequency;
从复数信号矩阵中取出EHG特征频率处的元素合集Cf;Extract the element set C f at the EHG eigenfrequency from the complex signal matrix;
将EHG特征频率处的元素合集Cf与对应的EHG频率特征阈值相减,得到特征频率矩阵W;The eigenfrequency matrix W is obtained by subtracting the element set C f at the EHG eigenfrequency and the corresponding EHG frequency eigenvalue threshold;
对特征频率矩阵W中的每一行的元素求和,得到表征EHG信号强度的列向量V,n为采样点总数;The elements of each row in the eigenfrequency matrix W are summed to obtain a column vector V representing the strength of the EHG signal, n is the total number of sampling points;
取列向量V中元素大于0且连续时间大于tmin小于tmax的下标集合为I,I为标记为EHG特征信号段的采样点的集合;Take the set of subscripts whose elements in the column vector V are greater than 0 and whose continuous time is greater than t min and less than t max as I, where I is the set of sampling points marked as the EHG feature signal segment;
绘制EHG曲线,EHG曲线为:Plot the EHG curve, the EHG curve is:
其中,i的取值为[1,n]。Among them, the value of i is [1,n].
EHG特征频率取2个或3个或4个或5个。EHG eigenfrequencies take 2 or 3 or 4 or 5.
本发明实施例提供的基于多维度信息融合的宫缩监测系统,一方面利用六轴传感器分析宫缩过程中孕妇腹部的运动状态,绘制宫缩运动曲线,可以避免因孕妇动作发生的重力加速度干扰和不同姿态对于子宫肌电信号特征提取的干扰,在动态环境下同样可检测到宫缩运动,增加了监测宫缩的维度,有效拓展了使用场景,另一方面对混合生物电信号先进行MECG信号分离,然后再进行EHG特征信号段标记,提取出EHG信号,可有效抑制MECG信号的干扰和传感器的运动伪迹带来的干扰,解决了现有的宫缩运动监测方法难以做到抑制子宫肌电信号的噪声干扰和在静态环境和动态环境下均可有效监测宫缩运动的技术问题。The uterine contraction monitoring system based on multi-dimensional information fusion provided by the embodiment of the present invention uses six-axis sensors to analyze the motion state of the abdomen of the pregnant woman during the uterine contraction, and draws the motion curve of the uterine contraction, which can avoid the interference of the acceleration of gravity caused by the movement of the pregnant woman And the interference of different postures on the feature extraction of uterine EMG signals, uterine contractions can also be detected in a dynamic environment, which increases the dimension of monitoring uterine contractions and effectively expands the usage scenarios. Signal separation, and then marking the EHG characteristic signal segment to extract the EHG signal, which can effectively suppress the interference of the MECG signal and the interference caused by the motion artifact of the sensor, and solve the problem that the existing uterine contraction motion monitoring method is difficult to suppress the uterus. The noise interference of EMG signals and the technical problems of effective monitoring of uterine contractions in both static and dynamic environments.
本发明实施例提供的基于多维度信息融合的宫缩监测系统,用于执行前述基于多维度信息融合的宫缩监测方法实施例中的基于多维度信息融合的宫缩监测方法,其原理与前述基于多维度信息融合的宫缩监测方法实施例中的基于多维度信息融合的宫缩监测方法相同,在此不再进行赘述。The uterine contraction monitoring system based on multi-dimensional information fusion provided by the embodiment of the present invention is used to execute the uterine contraction monitoring method based on multi-dimensional information fusion in the foregoing embodiment of the uterine contraction monitoring method based on multi-dimensional information fusion. The method for monitoring uterine contractions based on multi-dimensional information fusion in the embodiment of the method for monitoring uterine contractions based on multi-dimensional information fusion is the same, which will not be repeated here.
以上所述,以上实施例仅用以说明本发明的技术方案,而非对其限制;尽管参照前述实施例对本发明进行了详细的说明,本领域的普通技术人员应当理解:其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换;而这些修改或者替换,并不使相应技术方案的本质脱离本发明各实施例技术方案的精神和范围。As mentioned above, the above embodiments are only used to illustrate the technical solutions of the present invention, but not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand: The technical solutions described in the embodiments are modified, or some technical features thereof are equivalently replaced; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions in the embodiments of the present invention.
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