CN113599716B

CN113599716B - Photo-medical device

Info

Publication number: CN113599716B
Application number: CN202111026832.7A
Authority: CN
Inventors: 康建喜; 贾长建; 张国辉; 朱映光; 胡永岚; 王静; 李栋栋
Original assignee: Beijing Yiguang Medical Technology Research Institute Co ltd
Current assignee: Beijing Yiguang Medical Technology Research Institute Co ltd
Priority date: 2021-09-02
Filing date: 2021-09-02
Publication date: 2024-06-21
Anticipated expiration: 2041-09-02
Also published as: CN113599716A

Abstract

The application discloses an optical medical device, comprising: a central shaft; the seal adjusting cavity is wrapped at the end part of the central shaft; the flexible light source is arranged on the outer surface of the seal adjusting cavity and used for providing a therapeutic light source; and the adjusting channel is arranged along the central shaft and used for injecting substances into the sealing adjusting cavity so as to prop up the sealing adjusting cavity. After entering the body, the device can be unfolded along with the unfolding of the sealed adjusting cavity, so that a large-area treatment light source is provided; since the flexible light sources are only arranged on the surface of the support structure, i.e. only distributed at positions corresponding to the treatment area, light source losses in the path are avoided.

Description

Photo-medical device

Technical Field

The present disclosure relates generally to the field of photomedical technology, and more particularly to a photomedical device.

Background

The flexible light source is changeable in shape, so that the flexible light source can be suitable for various occasions, such as indoor illumination, photodynamic therapy and the like. Photodynamic therapy is a method for treating diseases directly using light or using light and medicine in combination, and has been used in clinical practice. There are two main ways of photodynamic therapy, one is direct phototherapy and the other is the synergistic effect of light and a drug (also called photosensitizer). Photodynamic therapy is favored because of its advantages of good selectivity, minimal trauma, good tolerability, simple handling, etc. Photodynamic therapy can be divided into in vivo therapy and in vitro therapy, wherein the in vivo therapy comprises bladder cancer, throat cancer, bronchus cancer and the like, and the light source for in vivo therapy is mainly a laser optical fiber which has the advantages of easy insertion into the body and small wound. However, the optical fiber has large light energy loss and poor light emitting uniformity, and the light energy irradiated to the focus through the optical fiber is relatively low in the treatment process of a large organ, which is unfavorable for photodynamic therapy.

Disclosure of Invention

In view of the foregoing deficiencies or inadequacies of the prior art, it is desirable to provide an photomedical device that includes:

A central shaft;

the seal adjusting cavity is wrapped at the end part of the central shaft;

the flexible light source is arranged on the outer surface of the seal adjusting cavity and used for providing a therapeutic light source;

and the adjusting channel is arranged along the central shaft and used for injecting substances into the sealing adjusting cavity so as to prop up the sealing adjusting cavity.

According to the technical scheme provided by the embodiment of the application, the adjusting channel is formed by an injection pipe fixed outside the central shaft, and the injection pipe extends into the sealing adjusting cavity.

According to the technical scheme provided by the embodiment of the application, the central shaft is hollow, and the cavity forms the adjusting channel; the central shaft is provided with a radial outlet corresponding to the seal adjusting cavity.

According to the technical scheme provided by the embodiment of the application, the sealing adjusting cavity is formed by fixing the flexible substrate on the outer wall of the central shaft, and the flexible light source is fixedly attached to the surface of the flexible substrate.

According to the technical scheme provided by the embodiment of the application, the flexible light source is a flexible OLED (organic light emitting diode) which is in a fusiform shape, and the edge of the flexible light source is fixed on the flexible substrate.

According to the technical scheme provided by the embodiment of the application, a row of connecting ribs are fixed on the bottom surface of the substrate of the OLED in the direction perpendicular to the central axis.

According to the technical scheme provided by the embodiment of the application, the flexible light source comprises at least one of an OLED light source, an LED light source, a quantum dot light source, a miniLED light source, a microLED light source and an optical fiber, and the flexible light source is coated with a skin-friendly material layer.

According to the technical scheme provided by the embodiment of the application, the lamp strip is fixed with the flexible light source and is woven on the outer surface of the seal adjusting cavity.

According to the technical scheme provided by the embodiment of the application, the substance is gas or liquid; preferably, the thermal conductivity of the liquid is not less than 0.5W/(mK).

According to the technical scheme provided by the embodiment of the application, the two sides of the sealing adjusting cavity on the central shaft are respectively provided with a sealed convex adjusting cavity, and the sealed convex adjusting cavities are used for injecting substances into the convex adjusting cavities to prop up the auxiliary adjusting channels.

The application designs the central shaft, the sealing adjusting cavity and the flexible light source arranged on the outer surface of the sealing adjusting cavity; the sealing adjusting cavity is filled with substances to prop up the sealing adjusting cavity, so that the flexible light source on the sealing adjusting cavity can be contracted along with the contraction of the sealing adjusting cavity and expanded along with the expansion of the sealing adjusting cavity, the device can conveniently enter a body in a small-volume structure, and can be expanded along with the expansion of the sealing adjusting cavity after entering the body, so that a large-area therapeutic light source is provided; since the flexible light source is only provided with the surface of the support structure, i.e. only distributed at the positions corresponding to the treatment area, light source losses in the path are avoided.

Drawings

Other features, objects and advantages of the present application will become more apparent upon reading of the detailed description of non-limiting embodiments, made with reference to the accompanying drawings in which:

fig. 1a is a schematic structural view of a first embodiment of example 1 of the present application;

FIG. 1b is a schematic structural diagram of a second embodiment of example 1 of the present application;

FIG. 2a is a schematic structural diagram of embodiment 2 of the present application;

FIG. 3a is a schematic structural diagram of a first arrangement of a flexible OLED according to embodiment 3 of the present application;

FIG. 3b is a schematic diagram of a second arrangement of flexible OLED in embodiment 3;

FIG. 4a is a schematic view showing an expanded structure of a woven strip according to embodiment 4 of the present application;

FIG. 4b is a schematic cross-sectional view of a woven strip according to example 4 of the present application;

FIG. 5a is a schematic structural diagram illustrating a first working state in embodiment 5 of the present application;

FIG. 5b is a schematic structural diagram showing a second working state in embodiment 5 of the present application;

reference numerals in the drawings:

10. A central shaft; 21. sealing the adjusting cavity; 30. a flexible light source; 20. a flexible substrate; 40. an injection tube; 41. an injection pipe I;42. an injection tube II; 43. a flat layer; 11. a regulating channel; 31. a flexible OLED;31-1, connecting ribs; 45. a light strip; 45-1, a transverse lamp strip; 45-2, longitudinal lamp strips; 50. an outer convex adjusting cavity; 51. the outer convex adjusting cavity I;52. the outer convex adjusting cavity II.

Detailed Description

The application is described in further detail below with reference to the drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the application and are not limiting of the application. It should be noted that, for convenience of description, only the portions related to the application are shown in the drawings.

It should be noted that, without conflict, the embodiments of the present application and features of the embodiments may be combined with each other. The application will be described in detail below with reference to the drawings in connection with embodiments.

Example 1

Referring to fig. 1, the present embodiment provides an optical medical device, including:

a central shaft 10;

a seal adjusting cavity 21 wrapping the end of the central shaft 10;

A flexible light source 30 disposed on the outer surface of the seal adjusting cavity 21 for providing a therapeutic light source;

A conditioning channel is provided along the central shaft 10 for injecting a substance into the sealed conditioning cavity 21 to prop it up.

Wherein, in the present embodiment, the central shaft 10 is made of steel wire, thin deformable plastic rod or plastic tube, hollow or solid rubber tube; the end of the sealing adjusting cavity 21 is used for stretching into the body for treatment, and the other end is exposed outside the body.

In this embodiment, the seal adjusting cavity 21 is formed by fixing a flexible substrate on the outer wall of the central shaft 10, and the flexible light source 30 is fixed on the surface of the flexible substrate 20.

The flexible substrate 20 may be made of rubber, PMDS, PTFE, fibroin, etc., and when the flexible light source is made of a sheet-like OLED, each OLED may be fixed on the surface of the flexible substrate by means of gluing; the fixed connection between the flexible substrate 20 and the central shaft is fixed by ultrasonic welding, laser welding, electric welding, or is sealed by sealant connection.

In some embodiments, the seal adjusting cavity 21 may be directly formed by using a plurality of spliced sheet-shaped OLEDs, where the OLED substrate is made of organic polymer materials such as parylene, rubber, and nitrile.

Wherein the tuning channel is optionally formed in the following manner:

embodiment 1: as shown in fig. 1a, the adjustment channel is formed by an injection tube 40 fixed outside the central shaft 10, the injection tube 40 extending into the sealed adjustment chamber 21.

At this time, an opening is formed at one end of the injection pipe 40 far away from the seal adjusting cavity 21, air is injected into the seal adjusting cavity 21 through the opening, at this time, preferably, an air pump connecting port is arranged at the opening, and after the air outlet of the air pump is connected with the connecting port, the air pump is started to realize the inflation into the seal adjusting cavity 21; in a further preferred embodiment, a pressure sensor is provided in the filling pipe 40 and the air pump stops the inflation when the pressure sensor reaches the set pressure, so that the seal adjusting chamber 21 is in a state where the pressure is constant. Preferably, a valve capable of being manually or electrically controlled to open and close is arranged in the injection pipe 40, so that when the pressure of the seal adjusting cavity 21 reaches a set value, the injection pipe 40 is disconnected from the air supply path of the inflator pump, and air supply is stopped; when the treatment is completed, the valve may be opened to vent the gas within the seal-conditioning chamber 21.

When the treatment is completed, the air is discharged through the opening of the injection tube 40, so that the sealing adjusting cavity 21 is contracted, the volume is reduced, and the device is taken out of the body.

In other embodiments, the gas may be replaced with a liquid and, correspondingly, the air pump replaced with a water pump. At this time, preferably the liquid thermal conductivity is > 0.5W/(mK); for example, physiological saline, is convenient for cool down the light-emitting device through the circulation of liquid, so as to prolong the working time of the device in the body and improve the working efficiency. And avoid pain caused by high temperature.

Embodiment 2: as shown in fig. 1b, the central shaft 10 is hollow, wherein a cavity forms the adjustment channel 11; the central shaft is provided with a radial outlet corresponding to the seal adjusting cavity 21.

At this time, the central shaft 10 is opened at an end far from the seal adjusting chamber 21, and the use process is the same as that of embodiment 1, and is not repeated.

In this embodiment, the color of the flexible light source may be red light, blue-green light, or blue light, or a light source with a mixture of colors:

the light irradiation depth of yellow green light with the wave band of 510 nm-590 nm is between blue light and red light, so that the dredging and the expansion of capillary vessels with the skin depth can be promoted, the resistance of cells can be enhanced, and the treatment effect of an affected part can be accelerated.

Red light with the wave band of 590-810 nm can lead mitochondria to release cytochrome c oxidase, increase adenosine triphosphate, and the cells provide energy by using the adenosine triphosphate, thereby promoting the metabolism of the cells; meanwhile, the red light irradiation heats molecules in blood vessels, regulates the vasodilation and improves the blood circulation;

blue light irradiation in the 440-510 nm band can be used for relieving pain and swelling caused by inflammation. Therefore, the embodiment can achieve a plurality of different treatment effects by arranging different light sources.

The flexible light source can also be at least one of OLED light source, LED light source, quantum dot light source, miniLED light source, microLED light source, optical fiber or the combination of any two or three.

In other embodiments, the flexible light source 30 is coated with a layer of skin-friendly material, such as a material of silicone gel, polydimethylsiloxane (PDMS), silica gel, collagen (Collagen), silica gel (Silicone Hydrogel), hydrogel (Hydrogel), hydrocolloid (Hydrocolloid), polyurethane (PU), polymethyl methacrylate (PMMA), polymethylpentene polymer (PMP), polyethylene (PE), polycarbonate, polystyrene, acrylonitrile butadiene styrene, polyolefin, polyamide, polyvinyl chloride, polyethylene, polypropylene, nylon, polyester, silicone, polyimide, polytetrafluoroethylene, polyethersulfone, polysulfone, polyetheretherketone, chitosan, pectin, gelatin, nylon, fiber, and the like.

The OLED light source and the LED light source are directly arranged on the surface of the supporting structure, and compared with the mode of single optical fiber treatment in the prior art, the loss on the path is avoided.

When the flexible light source is arranged on the surface of the supporting structure, compared with the single optical fiber treatment mode in the prior art, the supporting structure is unfolded during treatment, so that the supporting structure is closer to a focus area, and the loss caused by liquid is avoided. For example, some lesions are relatively large in organs such as bladder, and sometimes can block the affected part, and the whole bladder is supported by filling liquid during treatment, and light loss is caused by the existence of the liquid, especially in the case of a single optical fiber, the liquid needs to be transmitted from the end part of the optical fiber to the lesion, and the light loss is very serious; in the technical scheme of the application, the light source can be closer to the focus part by the supporting structure, the distance of light penetrating through the liquid is shorter, and correspondingly, the light loss is much smaller.

When the photomedical device provided by the embodiment is used for in-vivo treatment, the supporting structure and the flexible light source can be sent into the body by pushing the central shaft. The photomedical device provided by this embodiment may also be used for extracorporeal treatment by selectively energizing portions of the flexible light source to effect localized treatment.

Example 2

On the basis of embodiment 1, as shown in fig. 2a, in this embodiment, the flexible light source is a flexible OLED31, which is in the shape of a shuttle, and the edge of which is fixed on the flexible substrate 20.

When the seal adjusting cavity 21 is contracted, the flexible light source is folded along with the central line, and the central shaft is rotated clockwise or anticlockwise at the moment, so that the folded flexible light source and the fusiform sheets can be curled; if the flexible light source is curled clockwise before treatment, the central shaft 10 is rotated anticlockwise after entering the body to turn on the flexible light source.

In this embodiment, the flexible OLED may be curled by rotating the central shaft during shrinkage, so as to further reduce the volume of the entry end of the device, and provide convenience for use.

Example 3

In this embodiment, as shown in fig. 3a, a row of connection ribs 31-1 are fixed on the bottom surface of the substrate of the flexible OLED31 in the direction perpendicular to the central axis on the basis of embodiment 2.

Therefore, when the supporting structure is contracted, the folded part of the flexible OLED31 can avoid the situation that the flexible OLED31 is damaged by being folded completely, and particularly for the whole OLED light source, the connecting rib 31-1 increases the bending angle.

In other embodiments, as shown in fig. 3b, the effect of expanding the folding angle of the connecting rib can also be achieved by providing a greater thickness in the middle of the flexible OLED31 substrate along the length direction.

Example 4

As shown in fig. 4a and 4b, this embodiment differs from embodiment 1 in that, on the basis of embodiment 1, it is: the fixing mode of the light source is changed into a flexible knitting structure, and the flexible knitting structure covers the outside of the flexible base material 20; the light source is fixed to the strip, which in this embodiment, as shown in fig. 4a, comprises a transverse strip 45-1 and a longitudinal strip 45-2; the transverse light strip 45-1 and the longitudinal light strip 45-2 are woven on the supporting structure, and the transverse light strip 45-1 and the longitudinal light strip 45-2 may be made of thin rubber sheets, for example.

In this embodiment, the light sources are LED beads, and are connected by parallel or serial circuits, and the horizontal light strip 45-1 and the vertical light strip 45-2 are provided with a flat layer 43 covering all the light sources, and the flat layer is made of an organic material, such as PMMA, parylene, etc., and has a thickness 10 μm-50 μm higher than that of the light sources. The flat layer 43 allows the strip to be relatively flat, improving comfort during use.

In other embodiments, the LED lamp beads can be replaced by optical fibers or OLED light sources, and the optical fibers are attached to the transverse lamp strip 45-1 and the longitudinal lamp strip 45-2 along the length direction;

Since the lamps arranged throughout the strip are independent individuals with consistent illumination, the overall braided strip form will have better illumination uniformity relative to a massive, monolithic flexible light source; because the part of the large-block flexible light source far away from the bonding area emits light with darker brightness, and the part near the bonding area emits light with brighter brightness.

Example 5

In this embodiment, on the basis of embodiment 1, the central shaft 10 is provided with sealed outer adjusting cavities on both sides of the sealed adjusting cavity 21, and a secondary adjusting channel is used for injecting substances into the outer adjusting cavities to prop the outer adjusting cavities.

Wherein the male tuning cavity 50 is also surrounded by a flexible substrate. The outer convex adjusting cavity near the end of the central shaft 10 is an outer convex adjusting cavity I51, and the other outer convex adjusting cavity is an outer convex adjusting cavity II52. The convex adjusting cavity I51 is used for injecting substances through the injection pipe I41, the convex adjusting cavity II52 is used for injecting substances through the injection pipe II42,

The outer convex adjusting cavity I51, the outer convex adjusting cavity II52 and the sealing adjusting cavity 21 are respectively and independently controlled to realize shrinkage independently and freely.

As shown in fig. 5a, when the photomedical device is introduced into the body, the outer convex adjusting cavity I51 is filled with a substance, slightly expands, the outer convex adjusting cavity II52 and the seal adjusting cavity 21 are evacuated, and in a contracted state, the outer convex adjusting cavity I51 expands a temporary space between the front end of the entering direction and the skin tissue, so that the flexible light source outside the seal adjusting cavity 21 is prevented from directly contacting the skin tissue, and the flexible light source is protected.

Accordingly, as shown in fig. 5b, when the photomedical device is taken out of the body, the outer convex adjusting cavity II52 is filled with a substance and slightly inflated, the outer convex adjusting cavity I51 and the seal adjusting cavity 21 are evacuated, and in a contracted state, the outer convex adjusting cavity II52 expands a temporary space between the front end of the entering direction and the skin tissue, so that the flexible light source outside the seal adjusting cavity 21 is prevented from directly contacting the skin tissue, and the flexible light source can be protected.

The above description is only illustrative of the preferred embodiments of the present application and of the principles of the technology employed. It will be appreciated by persons skilled in the art that the scope of the application referred to in the present application is not limited to the specific combinations of the technical features described above, but also covers other technical features formed by any combination of the technical features described above or their equivalents without departing from the inventive concept. Such as the above-mentioned features and the technical features disclosed in the present application (but not limited to) having similar functions are replaced with each other.

Claims

1. A photomedical device, comprising:

A central shaft;

the seal adjusting cavity is wrapped at the end part of the central shaft;

a conditioning channel disposed along the central axis for injecting a substance into the sealed conditioning cavity to prop up the sealed conditioning cavity;

The central shaft is provided with sealed outer convex adjusting cavities at two sides of the sealed adjusting cavity, and an auxiliary adjusting channel for injecting substances into the outer convex adjusting cavities to prop up the outer convex adjusting cavities is formed in the central shaft;

The outer convex adjusting cavity close to the end part of the central shaft is an outer convex adjusting cavity I, and the other outer convex adjusting cavity is an outer convex adjusting cavity II;

the outer convex adjusting cavity I, the outer convex adjusting cavity II and the sealing adjusting cavity are respectively and independently controlled, so that independent free shrinkage is realized, the flexible light source outside the sealing adjusting cavity is prevented from being directly contacted with skin tissues, and the flexible light source is protected.

2. The photomedical device of claim 1, wherein the adjustment channel is formed by an injection tube secured outside the central shaft, the injection tube extending into the sealed adjustment lumen.

3. The photomedical device of claim 1, wherein the central shaft is hollow, wherein a cavity forms the adjustment channel; the central shaft is provided with a radial outlet corresponding to the seal adjusting cavity.

4. The photomedical device of claim 1, wherein the seal adjustment chamber is formed by a flexible substrate secured to an outer wall of the central shaft, and the flexible light source is secured to a surface of the flexible substrate.

5. The photomedical device of claim 4, wherein the flexible light source is a flexible OLED having its edges secured to the flexible substrate.

6. The photomedical device of claim 5, wherein the bottom surface of the OLED substrate has attachment ribs affixed perpendicular to the central axis.

7. The photomedical device of claim 1, wherein the flexible light source comprises at least one of an OLED light source, an LED light source, a quantum dot light source, a miniLED light source, a microLED light source, an optical fiber; the flexible light source is coated with a skin-friendly material layer.

8. The photomedical device of any one of claims 1 to 4, 7, wherein the substance is a gas or a liquid; the thermal conductivity of the liquid is more than or equal to 0.5W/(m.K).

9. The photomedical device of any one of claims 1-4, 7, further comprising a light strip to which the flexible light source is secured, the light strip being woven on the exterior surface of the seal accommodating chamber.