CN113397507B - Epileptic monitoring device and method for reducing epileptic monitoring false positive rate - Google Patents
Epileptic monitoring device and method for reducing epileptic monitoring false positive rateInfo
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- CN113397507B CN113397507B CN202110836073.4A CN202110836073A CN113397507B CN 113397507 B CN113397507 B CN 113397507B CN 202110836073 A CN202110836073 A CN 202110836073A CN 113397507 B CN113397507 B CN 113397507B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
- A61B5/02055—Simultaneously evaluating both cardiovascular condition and temperature
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
- A61B5/4094—Diagnosing or monitoring seizure diseases, e.g. epilepsy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/024—Measuring pulse rate or heart rate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
- A61B5/1118—Determining activity level
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Abstract
本发明公开了一种癫痫监测装置及其降低癫痫监测假阳性率方法，该监测装置包括：信息采集器、信息处理器和脉冲发生器；所述信息采集器用于采集患者的生理信号和加速度信号，所述生理信号包括体温信号和心率信号；所述信息处理器对加速度信号和体温信号进行分析处理得到患者的运动状态信息，对心率信号分析处理得到患者的心率状态信息，将所述运动状态信息和所述心率状态信息与相应的判定阈值对比，根据对比结果判断是否生成开启脉冲刺激的指令，并将指令发送至脉冲发生器，所述脉冲发生器根据所述指令在适当的时机开启脉冲刺激。根据本发明，脉冲发生器可根据需要而开启脉冲刺激，进一步降低体内植入单元的能耗。
The present invention discloses an epilepsy monitoring device and a method for reducing the false positive rate of epilepsy monitoring. The monitoring device includes: an information collector, an information processor, and a pulse generator; the information collector is used to collect physiological signals and acceleration signals of the patient, and the physiological signals include body temperature signals and heart rate signals; the information processor analyzes and processes the acceleration signals and body temperature signals to obtain the patient's motion state information, analyzes and processes the heart rate signals to obtain the patient's heart rate state information, compares the motion state information and the heart rate state information with corresponding judgment thresholds, determines whether to generate an instruction to start pulse stimulation based on the comparison result, and sends the instruction to the pulse generator, which starts pulse stimulation at an appropriate time based on the instruction. According to the present invention, the pulse generator can start pulse stimulation as needed, further reducing the energy consumption of the implanted unit in the body.
Description
Technical Field
The invention belongs to the field of medical treatment, and relates to an epileptic monitoring device and a method for reducing the false positive rate of epileptic monitoring.
Background
There are currently vagal stimulators that attenuate or directly relieve seizure threat by monitoring heart rate changes to predict seizures and releasing impulse stimulation. However, the influence of exercise on heart rate variation cannot be avoided, so that the stimulation is automatically started under the condition that the epileptic seizure is not yet left, that is, the false positive rate of epileptic monitoring is high. This not only increases the power consumption of the stimulator, reduces the stimulator lifetime (shortens the charging interval for rechargeable stimulators), but also the multiple large doses of stimulation initiated by false positives may cause damage to the patient's nerves.
Object of the Invention
The invention aims to overcome the problems in the prior art, and provides an epileptic monitoring device and a method for reducing the false positive rate of epileptic monitoring by integrating heart rate data, acceleration data, body temperature data and the like of a patient, so that the service life of a stimulator (the charging interval of the rechargeable stimulator is prolonged), and the damage to nerves of the patient is reduced.
Disclosure of Invention
According to one aspect of the present invention, there is provided an epileptic monitoring device comprising an information collector, an information processor and a pulse generator;
the information collector is used for collecting physiological signals and acceleration signals of a patient, wherein the physiological signals comprise a body temperature signal and a heart rate signal;
The information processor is used for processing the acceleration signal and the body temperature signal to obtain the movement state information of the patient, comparing the movement state information with a set movement judgment threshold value and judging whether movement is invalid or valid; judging whether to generate an instruction for starting pulse stimulation according to whether the heart rate state information exceeds a heart rate threshold value or not and combining with the judgment of motion invalidity or validity, and sending the instruction to the pulse generator;
the pulse generator turns on pulse stimulation according to the instruction.
Preferably, the motion state information includes acceleration information and body temperature information, and the decision threshold includes an acceleration threshold and a body temperature threshold.
More preferably, the acceleration threshold value includes a first acceleration threshold value and a second acceleration threshold value, which are used for judging the motion state in combination with the acceleration information.
More preferably, the movement state comprises resting or walking, low intensity movement, high intensity movement.
More preferably, the body temperature threshold value comprises a body temperature threshold value I and a body temperature threshold value II, and the body temperature threshold value I and the body temperature threshold value II are used for judging whether movement is invalid or valid by combining the body temperature information and the acceleration information.
More preferably, the movement state information further includes time information, and the determination threshold further includes a time threshold for determining whether movement is invalid or valid in combination with the time information, the body temperature information, and the acceleration information.
Preferably, the heart rate status information is a heart rate increase value.
More preferably, the acceleration threshold is set according to the increase amplitude of the heart rate of the patient, wherein the acceleration threshold is a minimum acceleration corresponding to the increase of the heart rate of the patient to 140% -160% of the resting heart rate of the patient, and the acceleration threshold is a minimum acceleration corresponding to the increase of the heart rate of the patient to 190% -210% of the resting heart rate of the patient.
According to another aspect of the present invention, there is provided a method for reducing the false positive rate of epileptic monitoring using the above epileptic monitoring device, comprising the steps of:
Step 1, collecting heart rate signals and acceleration signals of a patient through the information collector, analyzing to obtain acceleration information through the information processor, and identifying the motion state of the patient, wherein when the acceleration information is smaller than an acceleration threshold value, the motion state is judged to be a motion state I, and the step 2 is entered;
Step 2, judging whether timing is performed or not, if not, entering step 3, otherwise, entering step 6;
Step3, judging that the motion state is an initial motion state I, not starting body temperature acquisition, marking the motion as invalid, and entering a step 7;
step 4, timing and body temperature acquisition are carried out, if the timing exceeds a first time threshold value and the body temperature information exceeds a first body temperature threshold value, the movement is marked as effective, and the step 7 is entered;
step 5, timing and body temperature acquisition are carried out, if the timing exceeds a second time threshold value and the body temperature information exceeds a second body temperature threshold value, the movement is marked as effective, and the step 7 is carried out;
Step 6, judging that the motion state is a motion state I returned from a motion state II or a motion state III, not starting body temperature acquisition, and recording the motion as invalid and stopping timing after the timing exceeds a time threshold III;
And 7, if the heart rate state information of the patient exceeds a heart rate threshold value and the movement marks are invalid, generating an instruction for starting pulse stimulation, and returning to the step 1.
Preferably, in the step 1, it further includes determining whether the motion state changes, if so, resetting the original timing, and re-timing, otherwise, continuing to time.
Compared with the prior art, the invention has the innovation point that the epileptic detection and the patient movement state are combined, the false positive rate of the epileptic detection is reduced, and the invention has the following advantages:
1. According to the invention, the exercise state of the patient can be judged according to the acceleration data and the body temperature data of the patient, and after the heart rate data of the patient exceeds a set threshold value, the exercise state of the patient is combined to judge whether to start stimulation, so that the false start of stimulation caused by the rise of the heart rate due to the exercise of the patient is avoided, the false positive rate of epileptic detection and the damage to the nerves of the patient are reduced, and meanwhile, the electric quantity of a pulse stimulation generator is saved.
2. The acceleration threshold value setting of the invention is different from person to person, and different threshold values can be set for different patients, thus not only ensuring the accuracy of monitoring the exercise intensity, but also being more in line with personal habits.
3. The invention starts the body temperature monitoring only after the acceleration exceeds the first threshold value, which not only accords with the actual use situation, but also can further save the electric quantity of the stimulator.
4. The invention sets different timing time thresholds and body temperature thresholds for the motions with different intensities, can be more in line with the actual use scene, and improves the monitoring efficiency on the basis of ensuring accurate monitoring of the motion intensity.
Drawings
Fig. 1 is a schematic structural diagram of an epileptic monitoring device according to an embodiment of the present invention;
Fig. 2 is a method of reducing the false positive rate of epileptic monitoring by an epileptic monitoring device in an embodiment of the present invention.
Detailed Description
The present invention will be described in detail with reference to the accompanying drawings.
Fig. 1 is a schematic structural view of an epileptic monitoring device according to the present invention. The device is used for monitoring the morbidity state of a patient and comprises an information collector, an information processor and a pulse generator, wherein the information collector can comprise an acceleration sensor, a body temperature sensor and a heart rate sensor and is used for collecting physiological signals and acceleration signals of the patient, the physiological signals comprise body temperature signals and heart rate signals, the information processor analyzes and processes the acceleration signals and the body temperature signals to obtain movement state information of the patient, analyzes and processes the heart rate signals to obtain heart rate state information of the patient, compares the movement state information and the heart rate state information with corresponding judging thresholds, judges whether an instruction for starting pulse stimulation is generated according to a comparison result, and sends the instruction to the pulse generator, and the pulse generator starts pulse stimulation at proper time according to the instruction.
In a preferred embodiment, the individual units of the device may be implanted entirely within the body, or partially within the body and partially outside the body. For example, the pulse generator is implanted in a body, the information collector and the information processor are used as an external unit for monitoring physiological signals and acceleration signals in real time, and when the external unit generates an instruction for starting pulse stimulation according to judgment, the external unit communicates with the pulse generator in the body and sends the instruction to the pulse generator, so that the pulse generator can start pulse stimulation according to the requirement, and the energy consumption of the implanted unit in the body is further reduced.
In a preferred embodiment, the motion state information at least comprises acceleration information and body temperature information, and the motion judgment threshold value corresponding to the motion state information at least comprises an acceleration threshold value and a body temperature threshold value. The acceleration threshold value at least comprises a first acceleration threshold value and a second acceleration threshold value, and the first acceleration threshold value and the second acceleration threshold value are used for judging the motion state by combining the acceleration information. Wherein the first acceleration threshold is less than the second acceleration threshold. Specifically, when the acceleration information is smaller than or equal to the acceleration threshold value, the motion state is judged to be stationary or walking, when the acceleration information is larger than the acceleration threshold value I and smaller than the acceleration threshold value II, the motion state is judged to be low-intensity motion, and when the acceleration information is larger than or equal to the acceleration threshold value II, the motion state is judged to be high-intensity motion. The body temperature threshold comprises at least: and the body temperature threshold I and the body temperature threshold II are used for combining the body temperature information and the acceleration information to judge whether the movement is invalid or valid. Wherein the second body temperature threshold is greater than the first body temperature threshold. Specifically, when the motion state is low-intensity motion, if the body temperature information is greater than the first body temperature threshold value, the motion is judged to be effective, otherwise, the motion is judged to be ineffective, and when the motion state is high-intensity motion, if the body temperature information is greater than the second body temperature threshold value, the motion is judged to be effective, otherwise, the motion is judged to be ineffective.
In a preferred embodiment, the acceleration threshold value may be set according to the magnitude of increase in the patient's heart rate, where one is the minimum acceleration corresponding to the patient's heart rate increasing to 140% -160% of the patient's resting heart rate, and two is the minimum acceleration corresponding to the patient's heart rate increasing to 190% -210% of the patient's resting heart rate.
In a preferred embodiment, the motion state information further comprises time information, and the motion determination threshold value corresponding to the time information further comprises a time threshold value. The time threshold at least comprises a time threshold I, a time threshold II and a time threshold III, and the time threshold I, the time threshold II and the time threshold III are used for judging whether the movement is invalid or valid by combining the time information, the body temperature information and the acceleration information. Wherein the second time threshold is less than the first time threshold. Specifically, when the motion state is low-intensity motion, starting timing and body temperature acquisition, when the timing exceeds a time threshold value, and the body temperature information exceeds a body temperature threshold value, judging that the motion is effective, otherwise judging that the motion is ineffective, when the motion state is high-intensity motion, starting timing and body temperature acquisition, when the timing exceeds a time threshold value II, and the body temperature information exceeds a body temperature threshold value II, judging that the motion is effective, otherwise judging that the motion is ineffective, when the motion state is from low-intensity motion or high-intensity motion to stationary or walking, stopping the body temperature acquisition, restarting the timing, and when the timing exceeds a time threshold value III, judging that the motion is ineffective, otherwise judging that the motion is effective. If the time interval between the "resting or walking" and other movement states exceeds the time threshold three, the state can be considered as initial "resting or walking", in which the timing is closed, the body temperature acquisition is stopped, and the movement is judged to be invalid. It should be noted that if the motion state changes, the original timing is cleared and the timing is re-timed.
In a preferred embodiment, the heart rate status information at least comprises a heart rate increment value, and the corresponding decision threshold value further comprises a heart rate threshold value. The epileptic monitoring device judges whether to generate an instruction for starting pulse stimulation according to whether the heart rate increasing value exceeds a heart rate threshold value and by combining the judgment of whether the movement is invalid or valid in the embodiment. The method comprises the steps of generating an instruction for starting pulse stimulation if heart rate state information of a patient exceeds a heart rate threshold value and motion is judged to be invalid, generating no instruction for starting pulse stimulation or generating no instruction for starting pulse stimulation if the heart rate state information of the patient does not exceed the heart rate threshold value, and generating no instruction for starting pulse stimulation or generating no instruction for starting pulse stimulation if the heart rate state information of the patient exceeds the heart rate threshold value and motion is judged to be valid.
In a preferred embodiment, the acceleration information, the body temperature information, and the heart rate status information should be averaged over a certain sliding window interval.
The invention relates to a method for reducing false positive rate of epileptic monitoring, which comprises the following steps:
Step 1, collecting heart rate signals and acceleration signals of a patient through the information collector, analyzing to obtain acceleration information through the information processor, identifying the motion state of the patient, judging the motion state to be the motion state I when the acceleration information is smaller than or equal to an acceleration threshold value one, entering step 2, judging the motion state to be the motion state III when the acceleration information is larger than or equal to an acceleration threshold value II, entering step 5, otherwise, judging the motion state to be the motion state II, entering step 4, wherein the acceleration threshold value I and the acceleration threshold value II are set according to the heart rate of the patient, and the acceleration threshold value I is smaller than the acceleration threshold value II.
Further, in the first step, the first movement state may be stationary or walking, the second movement state may be low-intensity movement, and the third movement state may be high-intensity movement.
Step 2, judging whether timing is performed or not, if not, entering step 3, otherwise, entering step 6;
Step3, judging that the motion state is an initial motion state I, not starting body temperature acquisition, marking the motion as invalid, and entering a step 7;
step 4, timing and body temperature acquisition are carried out, if the timing exceeds a first time threshold value and the body temperature information exceeds a first body temperature threshold value, the movement is marked as effective, and the step 7 is entered;
step 5, timing and body temperature acquisition are carried out, if the timing exceeds a second time threshold value and the body temperature information exceeds a second body temperature threshold value, the movement is marked as effective, and the step 7 is carried out;
Step 6, judging that the motion state is a motion state I returned from a motion state II or a motion state III, not starting body temperature acquisition, and recording the motion as invalid and stopping timing after the timing exceeds a time threshold III;
And 7, if the heart rate state information of the patient exceeds a heart rate threshold value and the movement marks are invalid, generating an instruction for starting pulse stimulation, and returning to the step 1.
Further, in the step 1, it further includes determining whether the motion state changes, if so, resetting the original timing, and re-timing, otherwise, continuing to time.
Further, before the step 1, the method further includes initializing an acceleration threshold value one and an acceleration threshold value two, and specifically includes:
Step 0, collecting the resting heart rate of the patient, drawing an acceleration-real-time heart rate curve, finding out the minimum acceleration corresponding to the heart rate increased to 140% -160% of the resting heart rate, namely an acceleration threshold I, and finding out the minimum acceleration corresponding to the heart rate increased to 190% -210% of the resting heart rate, namely an acceleration threshold II. Wherein, the real-time heart rate should take an average value within a certain sliding window interval. In order to make the sliding window interval compatible with the real-time performance and accuracy of heart rate acquisition, in this embodiment, the sliding window interval is preferably set to 10 heart rate values.
The above examples are given for clarity of illustration only and are not limiting of the embodiments. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor is it exhaustive of all embodiments. While still being apparent from variations or modifications that may be made by those skilled in the art are within the scope of the invention.
Claims (7)
1. The epileptic monitoring device is characterized by comprising an information collector, an information processor and a pulse generator;
the information collector is used for collecting physiological signals and acceleration signals of a patient, wherein the physiological signals comprise a body temperature signal and a heart rate signal;
the information processor is used for processing the acceleration signal and the body temperature signal to obtain movement state information of a patient, comparing the movement state information with a set movement judgment threshold value, judging whether movement is invalid or valid, processing the heart rate signal to obtain heart rate state information of the patient, judging whether to generate an instruction for starting pulse stimulation according to whether the heart rate state information exceeds the heart rate threshold value or not and combining with the judgment of invalid or valid movement, avoiding false starting stimulation caused by the rising of the heart rate of the patient due to movement of the patient, and sending the instruction to the pulse generator;
the pulse generator starts pulse stimulation according to the instruction;
The motion state information comprises acceleration information and body temperature information, and the judging threshold value comprises an acceleration threshold value and a body temperature threshold value;
The acceleration threshold value comprises a first acceleration threshold value and a second acceleration threshold value, and is used for judging a motion state by combining the acceleration information;
the motion state includes resting or walking, low intensity motion, high intensity motion.
2. The epileptic monitoring device of claim 1, wherein the body temperature threshold includes a first body temperature threshold and a second body temperature threshold for determining whether movement is invalid or valid in combination with the body temperature information and acceleration information.
3. The epileptic monitoring device according to claim 1, wherein the movement state information further includes time information, the determination threshold further includes a time threshold for determining whether movement is invalid or valid in combination with the time information, the body temperature information, and the acceleration information.
4. The epileptic monitoring device of claim 1, wherein the heart rate status information is a heart rate increment value.
5. The epileptic monitoring device of claim 1, wherein the acceleration threshold is set according to an increase in patient heart rate, wherein the acceleration threshold is a minimum acceleration corresponding to a patient heart rate that increases to 140% -160% of a patient resting heart rate, and wherein the acceleration threshold is a minimum acceleration corresponding to a patient heart rate that increases to 190% -210% of a patient resting heart rate.
6. A method of reducing the rate of false positives for seizure monitoring using the seizure monitoring device according to one of claims 1-5, comprising the steps of:
Step 1, collecting heart rate signals and acceleration signals of a patient through the information collector, analyzing to obtain acceleration information through the information processor, and identifying the motion state of the patient, wherein when the acceleration information is smaller than or equal to an acceleration threshold value, the motion state is judged to be a motion state I, and the step 2 is entered;
Step 2, judging whether timing is performed or not, if not, entering step 3, otherwise, entering step 6;
Step3, judging that the motion state is an initial motion state I, not starting body temperature acquisition, marking the motion as invalid, and entering a step 7;
step 4, timing and body temperature acquisition are carried out, if the timing exceeds a first time threshold value and the body temperature information exceeds a first body temperature threshold value, the movement is marked as effective, and the step 7 is entered;
step 5, timing and body temperature acquisition are carried out, if the timing exceeds a second time threshold value and the body temperature information exceeds a second body temperature threshold value, the movement is marked as effective, and the step 7 is carried out;
Step 6, judging that the motion state is a motion state I returned from a motion state II or a motion state III, not starting body temperature acquisition, and recording the motion as invalid and stopping timing after the timing exceeds a time threshold III;
And 7, if the heart rate state information of the patient exceeds a heart rate threshold value and the movement marks are invalid, generating an instruction for starting pulse stimulation, and returning to the step 1.
7. The method of claim 6, wherein in step 1, it is further determined whether the motion state is changed, if so, the original timing is cleared, and the timing is resumed, otherwise, the timing is continued.
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| US8337404B2 (en) * | 2010-10-01 | 2012-12-25 | Flint Hills Scientific, Llc | Detecting, quantifying, and/or classifying seizures using multimodal data |
| US11642527B2 (en) * | 2008-01-25 | 2023-05-09 | Flint Hills Scientific, L.L.C. | Contingent cardio-protection for epilepsy patients |
| US8641646B2 (en) * | 2010-07-30 | 2014-02-04 | Cyberonics, Inc. | Seizure detection using coordinate data |
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