CN112138280B - Therapeutic apparatus with infinite electric stimulation function for resisting gastroesophageal reflux disease - Google Patents

Abstract

The invention particularly discloses a therapeutic apparatus with an infinite electric stimulation function for treating gastroesophageal reflux disease, which comprises a contraction device, an in-vivo control device, an operation device and an in-vitro control device, and is characterized in that the contraction device is attached to the outer wall of an esophagus and is close to the position of a cardiac, the contraction device comprises a tubular shell with an open end, a flexible lining symmetrically arranged on the inner wall of the tubular shell, and a plurality of electric elements integrated on the inner surface of the flexible lining, an inner cavity is formed between the inner surface of the tubular shell and the inner surface of the flexible lining, the upper end and the lower end of the inner cavity are encapsulated to form a closed cavity, and the in-vivo control unit responds to a control instruction sent by the in-vitro control device to control the operation device to change the flexible lining to contract the sphincter of the lower section of the esophagus so as to play a role of preventing reflux.

Description

A therapeutic instrument for anti-gastroesophageal reflux disease with infinite electric stimulation function

technical field

The invention relates to the technical field of bioengineering, in particular to a therapeutic instrument for resisting gastroesophageal reflux disease with infinite electric stimulation function.

Background technique

Gastroesophageal reflux disease (GERD) refers to the general term for gastroesophageal reflux and esophageal mucosal injury diseases caused by excessive contact (or exposure) of the esophageal lumen to the contents of the upper gastrointestinal tract; A disease in which duodenal contents reflux into the esophagus or even the oral cavity, causing clinical symptoms and/or esophageal inflammation. Reflux is mainly gastric acid, pepsin, duodenal juice, bile acid, pancreatic juice, etc. This disease is more common in clinical practice. Patients after subtotal gastrectomy, gastrointestinal anastomosis, and esophagoenterostomy more likely to happen. The occurrence of gastroesophageal reflux and its complications is multifactorial, including defects in the anti-reflux mechanism of the esophagus itself, such as dysfunction of the lower esophageal sphincter and abnormal movement of the esophageal body; there are also dysfunctions of many mechanical factors outside the esophagus, etc. .

GERD is very common in western countries. About 7%-15% of the population has gastroesophageal reflux symptoms. The incidence increases with age. The peak age of onset is 40-60 years old. Among patients with reflux disease, male patients are significantly more than female patients. The survey showed that the ratio of male to female incidence was 2.4:1. In recent years, GERD has shown a clear upward trend in the Asia-Pacific region. GERD can seriously affect the quality of life of patients. Patients with GERD often present with acid reflux, heartburn, throat and retrosternal discomfort; related symptoms outside the esophagus may also occur, such as chest pain, cough, hoarseness, and aspiration pneumonia. symptoms, and even death by suffocation.

About half of GERD patients see esophageal mucosal erosions, ulcers and other inflammatory lesions under the endoscope, which is called reflux esophagitis; The epidemic is called endoscopy-negative gastroesophageal reflux disease.

At present, there are three main treatment methods for GERD: (1) Drug therapy is the main treatment for GERD, but it is difficult to maintain long-term efficacy; (2) Fundoplication is a traumatic operation, and some patients have obvious dysphagia or abdominal distension after operation; (3) The radiofrequency treatment of the lower esophageal sphincter is a minimally invasive treatment under the endoscope. The radiofrequency ablation electrode needle currently used clinically uses a balloon to insert the electrode needle into the tissue to be treated by radiofrequency ablation, which will block the esophagus during treatment, and use Cooled by flushing water, the cooling water in the esophagus may flow out to the pharynx, and there is a risk of being inhaled by the patient into the trachea.

Contents of the invention

Aiming at the technical problems in the above-mentioned treatment, the present invention provides an anti-gastroesophageal reflux disease treatment instrument with unlimited electrical stimulation function. The device is operated by controlling the internal device through an external remote control, and the internal device can be safely stored in the body for a long time , has the function of timely assisting esophageal contraction and preventing gastroesophageal reflux.

The technical scheme adopted in the present invention:

A therapeutic instrument for anti-gastroesophageal reflux disease with infinite electrical stimulation function, comprising a contraction device, an internal control device, an operating device and an external control device, the contraction device is located on the outside of the lower esophageal sphincter and is attached to the outer wall of the esophagus and close to the cardia position, the shrinking device includes a tubular housing with an open end, a flexible lining symmetrically arranged on the inner wall of the tubular housing, a plurality of electrical components integrated on the inner surface of the flexible lining, the inner surface of the tubular housing and the flexible lining An inner cavity is formed between the inner surfaces and the upper and lower ends of the inner cavity are sealed to form a closed chamber. The in vivo control unit controls the operating device to change the flexible inner lining to shrink the esophagus wall in response to the control command issued by the external control device.

Preferably, the operating device hydraulically operates the constriction device, the operating device includes a bidirectional pump and a fluid reservoir, the fluid reservoir is connected to the bidirectional pump, and the control device in the body controls the bidirectional pump to transfer hydraulic fluid from the expandable reservoir Inner pumping into the two lumens within the tubular housing moves the two flexible linings against the esophageal wall.

Preferably, the tubular housing is made of polytetrachlorethylene material, an opening is provided on the side wall of the tubular housing and the opening runs through the longitudinal side wall of the tubular housing, and the two sides of the opening are connected in a locking manner, Easy to set on the esophagus.

Preferably, the flexible lining is made of polytetrafluoroethylene film, and the width of the flexible lining is 2/3 of the diameter of the tubular shell.

Preferably, the electrical elements are arranged laterally along the inner surface of the flexible lining to form at least 4 rows of electrical element paths, and each electrical element path includes at least 4 electrical elements arranged longitudinally along the inner surface of the inner lining.

Preferably, a pressure sensor attached to the wall of the esophagus is also arranged on the inner surface of the flexible lining.

The present invention compares with prior art, and its beneficial effect is:

When the present invention implants a constriction device for anti-reflux esophagitis with unlimited electrical stimulation function through laparoscopy to compress the esophagus wall to contract and stop the flow in the lumen, the internal control device is suitable for controlling the electrical components to stimulate simultaneously and cyclically The wall part is compressed, and the control device can control the electric element to change the stimulation to the esophagus wall in response to the sensed physiological parameter of the patient or the function parameter of the device, ie, the pressure parameter of the esophagus wall. It can effectively prevent gastroesophageal reflux, significantly improve the quality of life, avoid the long course of drug treatment, poor compliance and various complications caused by surgery. It greatly improves the safety and flexibility of treatment.

Description of drawings

In order to illustrate the technical solutions of the embodiments of the present invention more clearly, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention, and thus It should be regarded as a limitation on the scope, and those skilled in the art can also obtain other related drawings based on these drawings without creative work.

Fig. 1 is the structural representation of the therapeutic apparatus of the present invention implanted in the patient's body;

Fig. 2-4 is the longitudinal section of shrinking device among the present invention;

Fig. 5 is a block diagram of the hydraulic operation principle of the compression device.

Among them, 1-constriction device; 101-tubular shell; 102-flexible inner lining; 103-inner cavity; 104-electrical components; 2-operating device; 201-expandable reservoir; 202-bidirectional pump; 3-body control device; 4 - in vitro control device.

Detailed ways

In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments It is a part of embodiments of the present invention, but not all embodiments. The components of the embodiments of the invention generally described and illustrated in the figures herein may be arranged and designed in a variety of different configurations.

Accordingly, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

As shown in FIG. 1 , an anti-gastroesophageal reflux disease therapeutic instrument with infinite electrical stimulation function includes a constriction device 1 , an internal control device 3 , an operating device 2 and an external control device 4 .

Specifically, the control device 3 in the body is pasted with a polytetrafluoroethylene patch and fixed on the diaphragm with sutures. The casing of the control device 3 in the body is provided with an external interface, which is provided with a wireless transceiver integrated in the same control board. module, in vivo control module, stimulation signal generation module, energy supply module and pressure signal processing module. Among them, the energy supply module includes an energy collection unit, a power management unit, and an energy storage unit. The wireless transceiver module in the body is connected to the control module in the body for two-way wireless communication between the control device outside the body and the control device inside the body. The stimulation signal parameters and various control instructions are sent to the internal control module, and the esophageal wall pressure parameters output by the internal control module are sent to the external control device for storage. In addition, the internal wireless transceiver module is also connected with the energy harvesting module. The energy is extracted from the high-frequency electromagnetic wave signal received by the receiving device, and this part of the energy is processed by the power management module into a stable direct current suitable for charging, and temporarily stored in the energy storage module (such as a flexible battery). It is supplied to the control module in the body for related operations.

The control module in the body is also connected with the operating device 2. The operating device 2 hydraulically operates the contraction device 1. The operating device 2 includes a bidirectional pump 202 and a fluid reservoir 201. The fluid reservoir 201 is connected with the bidirectional pump 202. The control module will receive the control command sent by the extracorporeal control device and then control the two-way pump 202 to pump the hydraulic fluid in the fluid reservoir 201 to the constriction device to gently compress the esophageal wall in a compressed state (as shown in FIG. 5 ).

Wherein, the contraction device 1 is located on the outside of the lower esophageal sphincter and the outer wall of the esophagus and close to the cardia. The contraction device 1 includes a tubular shell 101 with an open end, and a flexible lining 102 symmetrically arranged on the inner wall of the tubular shell 101. A plurality of electrical components 104 integrated on the inner surface of the flexible lining 102, an inner cavity 103 is formed between the inner surface of the tubular housing 101 and the inner surface of the flexible inner lining 102, and the upper and lower ends of the inner cavity are sealed to form a closed chamber. The flexible lining 102 is made of polytetrafluoroethylene film, and the width of the flexible lining 102 is set to 2/3 of the diameter of the tubular shell 101, so that when the flexible lining expands, it squeezes the esophageal wall to form a contracted state. The two-way pump 202 communicates with the two lumens 103 through a hose, pumps hydraulic fluid into the lumen 103, increases the volume of the lumen 103, and then forces the flexible lining 102 to squeeze the esophageal wall, reducing the distance between the lumens of the esophagus , and the current pressure parameters of the esophageal wall measured by the pressure sensor arranged on the inner surface of the flexible lining 102 are fed back to the pressure signal processing module, which is used to amplify the original signal output by the pressure sensor and convert it into a digital signal for internal control The module is controlled by the control module in the body, and the electrical pulse signal with adjustable output parameters is output through the stimulation signal generation module to control the electrical element 104 to stimulate the esophageal wall to achieve contraction. The process is shown in Figure 2-4.

In the present invention, the electrical elements 104 are arranged laterally along the inner surface of the flexible lining to form at least 4 rows of electrical element paths, and each electrical element path includes at least 4 electrical elements arranged longitudinally along the inner surface of the inner lining. When the therapy device is in its stimulating state, it is important to stimulate the different parts of the esophageal wall in such a way that it basically maintains its natural physiological properties over time to prevent injury to said area, therefore, the internal control unit controls the pulse signal to occur The module uses bi-directional electric pulses (that is, a combination of positive and negative pulses) to function on the electrical components, and achieves the desired stimulation effect by changing different pulse parameters. The pulse current should be 1 to 30mA, and the pulse repetition frequency is suitably about 10Hz. To maintain the stimulating effect at all times, the internal control unit controls the pulse generating module to continuously energize each electrical element path in the series in a direction opposite to the flow direction in the lumen of the patient's esophagus. Each electrical element pathway that is not currently being stimulated is allowed to return to substantially normal blood circulation before it is re-stimulated.

In order to facilitate fixing the constriction device 1 to the wall of the esophagus, an opening is provided on the side wall of the tubular housing 101 and the opening runs through the longitudinal side wall of the tubular housing 101, and the two sides of the opening are connected in a locking manner. The tubular housing 101 is made of polytetrachlorethylene.

In the present invention, the external control device 4 can adopt a hand-held wireless remote controller, which can be conveniently operated by the patient to turn on and off the contraction device, and the wireless remote controller can also be designed to be applied to patient body. Such a watch-type remote controller may send out control signals that cause the patient's body to comply with the implanted device's signal-responsive equipment.

The above descriptions are only preferred embodiments of the present invention, and do not limit the present invention in any way. All simple modifications, changes and equivalent changes made to the above embodiments according to the technical essence of the invention still belong to the protection scope of the technical solution of the invention.

Claims (3)

1. The utility model provides a therapeutic apparatus with infinite electric stimulation function for treating gastroesophageal reflux disease, includes constriction device, internal controlling means, operating means and external controlling means, characterized in that, constriction device is located the lower esophageal sphincter outside and the outer wall laminating of esophagus and is close to the position of cardiac, constriction device includes tubular casing that has open end, the flexible inside lining of symmetrical arrangement in tubular casing inner wall, a plurality of electric elements of integration in flexible inside lining internal surface, form the inner chamber between tubular casing internal surface and the flexible inside lining internal surface and encapsulate the inner chamber upper and lower extreme and form sealed cavity, internal controlling means responds to the control command that external controlling means sent and controls operating means to change flexible inside lining and contract lower esophageal sphincter;

the operating device hydraulically operates the constriction device, the operating device comprising a bi-directional pump and a fluid reservoir, the fluid reservoir being connected to the bi-directional pump, the in-body control device controlling the bi-directional pump to pump hydraulic fluid from within the expandable reservoir into two lumens within the tubular housing to move the two flexible liners against the esophageal wall;

the tubular shell is made of polytetrafluoroethylene, an opening is formed in the side wall of the tubular shell and penetrates through the longitudinal side wall of the tubular shell, and two sides of the opening are connected in a locking manner, so that the tubular shell is conveniently sleeved on an esophagus;

the flexible lining is made of polytetrafluoroethylene film, and the width of the flexible lining is 2/3 of the diameter of the tubular shell.

2. A gastroesophageal reflux disease-resistant therapeutic device with electro-static stimulation function according to claim 1, wherein the electrical elements are arranged transversely along the inner surface of the flexible liner to form at least 4 rows of electrical element paths, each electrical element path comprising at least 4 electrical elements arranged longitudinally along the inner surface of the liner.

3. The therapeutic apparatus for gastroesophageal reflux disease with an infinite electric stimulation function according to claim 1, wherein the inner surface of the flexible lining is further provided with a pressure sensor attached to the esophageal wall.

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