CN112006670A - Control system for composite venous catheter and real-time monitoring of central venous pressure - Google Patents

Abstract

The application relates to the technical field of medical instruments, in particular to a control system for a composite venous catheter and a real-time monitoring central venous pressure. The composite intravenous catheter comprises: a peripheral lumen; a central lumen located in the inner space of the peripheral lumen, the central lumen being configured to receive a pressure sensor and a line for conducting a signal of the pressure sensor, the pressure sensor being located at the implanted end of the compound venous catheter; at least one diaphragm is arranged between the central lumen and the peripheral lumen; the at least one diaphragm is connected to the outer side wall of the central lumen on one side and the inner side wall of the peripheral lumen on the other side so as to form at least two channels between the outer side wall of the central lumen and the inner side wall of the peripheral lumen, and the channels in the at least two channels are independent of each other. The catheter is safe, reliable, long in service life, good in biocompatibility, capable of being processed in batches, and direct and accurate in real-time measurement.

Description

A composite venous catheter and a control system for real-time monitoring of central venous pressure

technical field

The application relates to the technical field of medical devices, in particular to a composite venous catheter and a control system for real-time monitoring of central venous pressure.

Background technique

Laparoscopic hepatectomy has attracted much attention due to its advantages of less surgical trauma and faster postoperative recovery. At present, with the development of laparoscopic technology and the improvement of surgical instruments, laparoscopic hepatectomy has been widely carried out, and the surgical indications have been continuously expanded. . Intraoperative bleeding that is difficult to control is the most common factor for converting laparoscopic hepatectomy to laparotomy. Therefore, effective prevention of intraoperative bleeding and timely and effective control of bleeding are the keys to the smooth implementation of laparoscopic hepatectomy. Intraoperative bleeding is more important.

Low central venous pressure technology is the key technology to prevent intraoperative bleeding, but it is difficult to monitor central venous pressure accurately in real time. The current method for detecting central venous pressure is to use transducers for conversion, because the volume of ordinary transducers is too large and can only be connected to a remote test device through a long line, that is, far from the venous pressure measurement position, and cannot be directly tested in situ. Moreover, the remote test will be interfered by factors such as the experience of the anesthesiologist, the position of the surgical patient, and the pressure of the laparoscopic pneumoperitoneum, and the accuracy needs to be strengthened. In order to perform laparoscopic hepatectomy more safely, a real-time and accurate device for monitoring central venous pressure is urgently needed in the clinical work of laparoscopic hepatectomy.

SUMMARY OF THE INVENTION

At present, there is no equipment that can urgently monitor central venous pressure in real time and accurately in the clinical work of laparoscopic hepatectomy, because of the following technical difficulties: the miniature pressure sensor chip based on optical fiber transmission that meets the volume requirements in the industry due to its processing technology The reason is that the sensor is easily damaged and the measurement range is not applicable, so it cannot be directly applied to the measurement of central venous pressure. Its measurement range is usually 6-42 cm H ₂ O, that is, it cannot cover the 0-5 cm H ₂ O range, (while the 0-5 cm H ₂ O pressure range is very important, especially when it is close to 0 cm H ₂ O, it is dangerous. monitoring area.) that is, does not cover the measurement range 0-15 cmH ₂ O required for low central venous pressure.

The present application provides a composite catheter suitable for in-situ measurement of central venous pressure and a manufacturing process thereof. The sensor offset can be adjusted arbitrarily manually to solve the problem of range mismatch in the production process. At the same time, the present application also has good biocompatibility, and the improvement of biocompatibility is completed simultaneously with the assembly of the sensor, thereby improving performance and saving production costs. In summary, the catheter uses a micro pressure sensor chip attached to the tip of the optical fiber to detect central venous pressure, and can perform in-situ pressure detection; the adjustable offset structure design can adjust the offset of the sensors on the market to reach the central vein range required for pressure measurement. The solutions of the embodiments of the present application are safe, reliable, have a long service life, have good biocompatibility, can be processed in batches, and are directly and accurately measured in real time. Because the intervention of the human body is a passive period, it does not involve R&D and design related to electromagnetic compatibility safety, which has the advantages of simpler approval than active pressure sensors and faster time to market.

In a first aspect, the embodiments of the present application provide a composite venous catheter, comprising: a peripheral lumen; a central lumen located in the inner space of the peripheral lumen, the central lumen being used for accommodating a pressure sensor and conducting The circuit of the pressure sensor signal, the pressure sensor is located at the implantation end of the composite venous catheter; there is at least one diaphragm between the central lumen and the peripheral lumen; the at least one diaphragm is connected on one side to the outer sidewall of the central lumen, and the other side is connected to the inner sidewall of the peripheral lumen to form at least two between the outer sidewall of the central lumen and the inner sidewall of the peripheral lumen channel, each of the at least two channels is independent of each other; wherein, in the use state of the composite venous catheter, the implantation end is used for implanting into the venous blood vessel of the subject, and the pressure sensor Used to detect venous pressure; the at least two channels are used to deliver medical fluid.

In some embodiments, the pressure sensor is an optical fiber pressure sensor, and the line for conducting the signal of the pressure sensor is a signal conducting optical fiber of the optical fiber pressure sensor; when the composite venous catheter is not in use, The included angle between the first diaphragm and the first tangent is not 90 degrees, the first diaphragm is any one of the at least one diaphragm, and the first tangent is the first diaphragm A tangent to the junction of the diaphragm and the lateral wall of the central lumen.

In some embodiments, in the non-use state of the composite venous catheter, the angle between the first diaphragm and the first tangent is 30 degrees to 60 degrees, or, the first diaphragm and the The included angle between the first tangents is 120°-150°.

In some embodiments, the pressure sensor is or includes a silicon sensor chip.

In some embodiments, the pressure sensor has an original sensing surface of the sensor, and the original sensing surface of the sensor is in a convex state under the action of the hydrogel.

In some embodiments, a sensor package sensing surface is also provided outside the original sensing surface of the sensor, the sensor package sensing surface is coated with medical Parylene series materials, and the thickness of the sensor package sensing surface is 1-10µm.

In some embodiments, the at least one diaphragm is three diaphragms evenly distributed between the central lumen and the peripheral lumen, and the at least two channels are between the central lumen and the peripheral lumen. 4 channels evenly distributed between the peripheral lumens.

In some embodiments, the first channel has a plurality of outlets at the implant end, and the first channel is any one of the at least two channels.

In a second aspect, an embodiment of the present application provides a control system for real-time monitoring of central venous pressure, including the composite venous catheter, the infusion pump and the interferometric pressure detector described in the first aspect; wherein the insertion end of the composite venous catheter is inserted into the To the infusion pump port, the line in the composite venous catheter for conducting the pressure sensor signal is connected to the interferometric pressure probe.

In some embodiments, the infusion pump is a motor-controlled peristaltic pump.

The solutions provided in the examples of the present application have the following solutions.

1. Small in size, it only needs one minimally invasive insertion into the blood vessel to simultaneously detect the pressure and give a variety of liquid medicines, which can reduce the number of trauma compared with the traditional method. The independent input of multiple drug solutions can be independently controlled, which overcomes the problem of the residual amount remaining in the lumen of the previous drug injection when the traditional intravenous catheter is used to inject drugs, and improves the accuracy of drug dose control. The system can realize closed-loop measurement and automatically control the central venous pressure in a safe range, so that the surgeon can focus on the minimally invasive surgery itself.

2. When preparing for laparoscopic hepatectomy, anesthesiologists routinely insert a central venous catheter. The application of this composite venous catheter can serve two birds with one stone, including rapid infusion and real-time monitoring of central venous pressure. Reduced trauma and increased load cell stability.

3. The composite venous catheter provided in the embodiment of the present application uses a silicon sensor chip attached to the tip of the optical fiber to detect central venous pressure, which has a direct, accurate and real-time effect, avoiding the experience of anesthesiologists, the position of the surgical patient, and laparoscopic pneumoperitoneum. stress and other factors. In particular, a micro pressure guiding channel for lateral pressure measurement is designed, so that the sensitive surface of the sensor can be stored in the composite tube to detect the central venous pressure and prevent the sensitive surface of the sensor from being damaged.

4. The solutions provided by the embodiments of the present application have the effect of protecting the optical fiber pressure sensor from bending, so that the bending stability of the optical fiber pressure sensor is improved.

5. The embodiment of the present application proposes a package design and processing technology of a sensing surface of a sensor. Combined with the specific fine-tuning structure of the review tube, this process has the effect of protecting the sensor from physical and chemical damage, while increasing or decreasing the offset to adjust the sensor range to make it suitable for intraoperative central venous pressure measurement.

Description of drawings

1 is a perspective view of a composite venous catheter provided by an embodiment of the application;

2 is a cross-sectional view of a composite venous catheter provided in an embodiment of the application;

3 is a cross-sectional view of the composite venous catheter provided in an embodiment of the application in a bent state;

4 is a schematic structural diagram of a sensor module in a composite venous catheter provided by an embodiment of the present application;

FIG. 5 is a schematic structural diagram of a pressure sensor in a composite venous catheter provided by an embodiment of the present application.

Detailed ways

The following examples are intended to illustrate the present application only and should not be construed as limiting the scope of the present application. If the specific conditions are not indicated in the examples, it is carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used without the manufacturer's indication are conventional products that can be purchased from the market.

Before further describing the specific embodiments of the present application, it should be understood that the protection scope of the present application is not limited to the following specific specific embodiments; it should also be understood that the terms used in the examples of the present application are for describing specific specific embodiments, Rather than limiting the scope of protection of this application; in the specification and claims of this application, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise.

When numerical ranges are given in the examples, it is to be understood that, unless otherwise indicated herein, both endpoints of each numerical range and any number between the two endpoints may be selected. Unless otherwise defined, all technical and scientific terms used in this application have the same meaning as commonly understood by one of ordinary skill in the art. In addition to the specific methods, equipment, and materials used in the examples, those skilled in the art can also use the methods, equipment, and materials described in the examples of the present application, according to the mastery of the prior art by those skilled in the art and the records of the present application. Any methods, devices and materials of the similar or equivalent prior art to carry out the present application.

The embodiment of the present application provides a composite venous catheter and a control system for real-time monitoring of central venous pressure. During laparoscopic liver resection, while intravenously injecting drugs, the central venous pressure can be monitored in real time and accurately, allowing laparoscopic liver resection Surgery is safer. Small in size, it only needs one minimally invasive procedure to detect pressure and administer multiple liquid medicines at the same time, thereby reducing the number of traumas. The independent input of multiple drug solutions can be independently controlled, which overcomes the problem of the residual amount remaining in the lumen of the previous drug injection when the traditional intravenous catheter is used to inject drugs, and improves the accuracy of drug dose control. The system can realize closed-loop measurement and automatically control the central venous pressure in a safe range, so that the surgeon can focus on the minimally invasive surgery itself.

In some embodiments, the composite venous catheter has a front-end pressure measurement function, and has the functions of multiple infusion tubes, pressure measurement, drug administration, and closed-loop control of central venous pressure. The overall design has the characteristics of good robustness, accurate measurement and small volume, and its implementation effect can reduce trauma, simplify surgical steps, and thus reduce surgical risks; the composite venous catheter structure includes a central lumen and a peripheral lumen, and the peripheral lumen wall It is inclined relative to the axial direction. The central lumen is used to store the fiber optic pressure sensor and its signal conducting fibers. The peripheral lumen is used to conduct the liquid medicine and play the role of isolation buffer to protect the optical fiber pressure sensor. There are also the following advantages: since the peripheral lumen wall is inclined relative to the axial direction, it allows a larger range of motion of the fiber optic pressure sensor to relieve bending pressure. At the same time, there are multiple infusion channels in the peripheral lumen, allowing independent input and independent control of various liquid medicines; each lumen in the peripheral lumen has multiple outlets, which can prevent thrombus blockage and reduce medical risks; support continuous or pulsatile dosing The pulsatile type can clear the thrombus blocking the liquid outlet and reduce the medical risk; the composite venous catheter has good biocompatibility and can correct the offset of the sensor tip protection structure and its processing technology, and its implementation effect can solve the current problem. The existing silicon pressure sensors on the market cannot be applied to the problem of central venous pressure measurement.

Next, the solutions of the embodiments of the present application will be described in detail with reference to FIGS. 1 to 5 .

As shown in FIG. 1 , the embodiment of the present application provides a composite venous catheter 1, including: a peripheral lumen; a central lumen located in the inner space of the peripheral lumen, the central lumen is used for accommodating a pressure sensor and a a line for conducting the signal of the pressure sensor, the pressure sensor is located at the implantation end of the composite venous catheter; there is at least one diaphragm between the central lumen and the peripheral lumen; the at least one diaphragm One side is connected to the outer sidewall of the central lumen and the other side is connected to the inner sidewall of the peripheral lumen so as to form between the central lumen and the outer sidewall and the inner sidewall of the peripheral lumen At least two channels, each channel in the at least two channels is independent of each other; wherein, in the use state of the composite venous catheter, the implantation end is used to implant into the vein blood vessel of the subject, so The pressure sensor is used to detect the venous pressure; the at least two channels are used to deliver the medicinal liquid.

The central lumen can be the sensing channel 11 shown in FIG. 1 , and the outlet of the sensing channel 11 at the implantation end is the sensing channel outlet 111 . The channel in the at least two channels may be the infusion channel 12 shown in FIG. 1 , and the outlet of the infusion channel 12 at the implantation end is the infusion channel outlet 121 . The pressure sensor and the lines for conducting the signal of the pressure sensor belong to the sensor module 2 in FIG. 1 .

The peripheral lumen, the central lumen and the diaphragm in the composite venous catheter 1 can be made of special medical materials, such as fluoroplastics, PU, etc., which are suitable for the porous extrusion molding process.

In some embodiments, the pressure sensor is an optical fiber pressure sensor, and the line for conducting the signal of the pressure sensor is a signal conducting optical fiber of the optical fiber pressure sensor; when the composite venous catheter is not in use, The included angle between the first diaphragm and the first tangent is not 90 degrees, the first diaphragm is any one of the at least one diaphragm, and the first tangent is the first diaphragm A tangent to the junction of the diaphragm and the lateral wall of the central lumen. The signal conducting fibers may be sensor conducting fibers 23 as shown in FIG. 4 .

As shown in Figures 2 and 3, the diaphragm between the central lumen and the outer sidewall of the peripheral lumen and the inner sidewall of the peripheral lumen is inclined relative to the axial direction of the central lumen, so that when the composite venous catheter is bent, the fiber is in The interior of the composite venous catheter is free to move in multiple directions to reduce the bend radius.

In some embodiments, in the non-use state of the composite venous catheter, the angle between the first diaphragm and the first tangent is 30 degrees to 60 degrees, or, the first diaphragm and the The included angle between the first tangents is 120°-150°.

By controlling the inclination angle of the diaphragm relative to the central lumen, when the composite venous catheter is bent, the optical fiber moves freely in multiple directions inside the composite venous catheter, so as to reduce the bending radius.

In some embodiments, the pressure sensor is or includes a silicon sensor chip.

In some embodiments, referring to FIGS. 4 and 5 , the pressure sensor has a sensor original sensing surface 21 , and the sensor original sensing surface 21 is in a convex state under the action of the hydrogel. The original sensing surface 21 of the sensor is the first layer of protective material, which exhibits a raised state as shown in FIG. 4 under the action of the sensor encapsulation hydrogel 24 . The sensor encapsulating hydrogel 24 may be a low stiffness PDMS material.

In some embodiments, a sensor package sensing surface 22 is further provided outside the original sensing surface of the sensor. The sensor package sensing surface 22 is coated with medical Parylene series materials. The sensor package sensing surface 22 The thickness is 1-10µm. The sensing surface 22 of the sensor package adopts medical Parylene series materials, such as Parylene-C, Parylene-N, Parylene-D and so on. The sensing surface 22 of the sensor package can be prepared by a Parylene CVD coating process.

In some embodiments, the at least one diaphragm is three diaphragms evenly distributed between the central lumen and the peripheral lumen, and the at least two channels are between the central lumen and the peripheral lumen. 4 channels evenly distributed between the peripheral lumens. There are multiple infusion channels, which allow independent input and independent control of multiple liquid medicines.

In some embodiments, the first channel has a plurality of outlets at the implant end, and the first channel is any one of the at least two channels. Each infusion channel has multiple outlets, which can prevent thrombus blockage and reduce medical risks.

The embodiment of the present application also proposes a control system for monitoring central venous pressure in real time, including a composite venous catheter 1, an infusion pump (not shown) and an interferometric pressure detector (not shown); wherein, the composite venous catheter 1 The insertion end is inserted into the infusion pump port, and the line in the composite venous catheter 1 for conducting the pressure sensor signal is connected to the interferometric pressure detector.

In some embodiments, the infusion pump is a motor-controlled peristaltic pump.

Next, the composite venous catheter and the use of the control system are introduced.

First, connect the insertion end of the composite venous catheter to the port of the infusion pump, and connect the optical fiber to the interferometric pressure probe. Calibrate the zero point and input the liquid medicine to the infusion pump. Set the desired central venous pressure range, and after the composite tube is implanted in the appropriate location, the automatic pressure control function can be turned on.

Optical fiber protection principle: Because the diameter of the composite tube is slender, the internal space needs to be reserved as much as possible for the delivery of the liquid medicine. This is because of the surface tension of the liquid medicine, which requires a strong pressure to deliver the liquid medicine, and the amount of the medicine is difficult to control. Drug delivery device design has long been difficult. Therefore, the optical fiber cannot be protected by the traditional method of adding a casing, that is, the optical fiber is no longer a neutral area when bending. The structure of the present invention allows the optical fiber to move freely in multiple directions inside the composite tube to reduce the bend radius. As shown in Figures 2 and 3, when the composite tube is bent, the fiber is deflected to one side to reduce bending stress.

The manufacturing and assembling process of the composite venous catheter 1 is as follows.

Assembly process of sensor module 2:

First, a traction sleeve (not shown) is placed over the sensor module 2 .

Then, the traction cannula is passed through the sensing channel 11 of the composite venous catheter 1. Since the traction cannula is relatively rigid and thin, it can easily enter the sensing channel 11 and pass through the sensing channel outlet 111).

Next, the sensor module 2 is pulled through the sensing channel 11 through the pulling sleeve, and the sensing surface 22 of the sensor package is made to reach the position close to the port inside the outlet 111 of the sensing channel.

Finally, continue to pull the pulling sleeve 3 to make it withdraw from the sensing channel 11 .

Thereby, the composite venous catheter 1 shown in FIG. 1 can be obtained.

Next, the packaging process of the sensor module 2 is introduced.

The separation can be achieved by slowly pulling the sensor module 2 away from the composite venous catheter 1 .

Next, the packaging and processing technology of the original sensing surface 21 of the sensor (need to be specified) is introduced.

First, the original sensing surface 21 of the sensor can use a glue dispenser to add an appropriate amount of PDMS hydrogel. Store in a vacuum at room temperature, and keep the original sensing surface 21 of the sensor to form a protrusion vertically downward until the hydrogel solidifies. If the hydrogel does not form bulges, this step can be repeated again. Next, the sensor module 2 with the sensor package sensing surface 22 is subjected to the ParyleneCVD coating process. The thickness of the coating is 1-10µm, which should not affect the sensitivity of the sensor.

The original sensing surface 21 of the sensor and the conductive optical fiber 23 of the sensor can be commercially available and can be purchased in one piece. The maximum outer diameter of the original sensing surface 21 of the sensor and the conducting fiber 23 of the sensor does not exceed 0.25mm.

The package structure of the sensor module 2 is shown in FIG. 4 , including: the original sensor surface 21 of the sensor, the sensor package sensor surface 22 , the sensor conductive fiber 23 , and the sensor package hydrogel 24 . The original sensing surface 21 of the sensor is connected to the sensor package hydrogel 2.4 , the sensor package hydrogel 24 is connected to the sensor package sensing surface 22 , and the sensor package sensing surface 22 is connected to the sensor conductive fiber 23 . The sensor conducting fiber 2.3 is connected to the back-end test system.

Next, the sensor offset adjustment procedure is described.

The diameter of the central lumen port is enlarged by the lumen expansion cone, and a tapered tip port is formed. The fiber optic pressure sensor fiber was inserted into the composite tube from the tapered tip port by pulling the guide wire, and the optical fiber was introduced and passed through the central lumen of the composite tube by pulling the pulling wire. The pulling wire was removed and the fiber was inserted into the interferometric pressure detector. Under standard atmospheric pressure, by pulling the fiber, the pressure sensor enters the tapered port, continue to pull the fiber, and observe the pressure reading, when the reading is a suitable offset such as 10 cmH ₂ O, stop pulling, use medical epoxy Fix the optical fiber, sensor and composite lumen with glue, and observe the pressure offset.

Next, the mode of administration is described.

The peristaltic pump is controlled by a private service motor, and the peristaltic pump is controlled by squeezing the liquid storage chamber. Among them, in the state of continuous administration, the peristaltic pump is driven by a constant torque mode; in the state of pulsatile administration, the peristaltic pump is driven by a constant speed mode.

In the embodiment of the present application, a composite venous catheter for real-time monitoring of central venous pressure is used to monitor central venous pressure in real time and accurately during laparoscopic liver resection. The composite venous catheter has the characteristics of stable performance, small volume, parallel administration and pressure measurement, and small trauma. In the described process, the multiplexed infusion channel is used as the protection channel of the pressure sensor and its conducting optical fiber; on the other hand, the packaging method of the sensor proposed by the present invention not only protects the sensor, but also meets the biocompatibility requirement of short-term contact with blood ; Again, the proposed packaging method combined with the special structure of the composite tube can adjust the offset of the pressure sensor so that it is not affected by the processing technology.

The implementation effect of the present application can make laparoscopic liver resection safer, reduce intraoperative bleeding, and improve patient outcomes.

The specific embodiments described above further describe the purpose, technical solutions and beneficial effects of the present application in detail. It should be understood that the above descriptions are only specific embodiments of the present application, and are not intended to limit the Within the scope of protection, any modification, equivalent replacement, improvement, etc. made within the spirit and principle of this application shall be included in the protection scope of this application.

Claims (10)

1. a composite venous catheter, is characterized in that, comprises: peripheral lumen; a central lumen located in the inner space of the peripheral lumen, the central lumen is used for accommodating a pressure sensor and a line for conducting a signal of the pressure sensor, and the pressure sensor is located at the implantation end of the composite venous catheter; There is at least one diaphragm between the central lumen and the peripheral lumen; one side of the at least one diaphragm is connected to the outer side wall of the central lumen, and the other side is connected to the inner side of the peripheral lumen a wall so as to form at least two channels between the outer sidewall of the central lumen and the inner sidewall of the peripheral lumen, each of the at least two channels being independent of each other; Wherein, when the composite venous catheter is in use, the implantation end is used for implanting into the venous blood vessel of the subject, the pressure sensor is used for detecting venous pressure; the at least two channels are used for delivering drugs liquid. 2. The composite venous catheter according to claim 1, wherein the pressure sensor is an optical fiber pressure sensor, and the line for conducting the signal of the pressure sensor is a signal conducting fiber of the optical fiber pressure sensor; In the non-use state of the composite venous catheter, the angle between the first diaphragm and the first tangent is not 90 degrees, and the first diaphragm is any one of the at least one diaphragm , the first tangent is the tangent at the connection between the first diaphragm and the outer sidewall of the central lumen. 3. The composite venous catheter according to claim 2, wherein in the non-use state of the composite venous catheter, the angle between the first diaphragm and the first tangent is 30°-60° degrees, or, the included angle between the first diaphragm and the first tangent is 120°-150°. 4. The composite venous catheter according to claim 2, wherein the pressure sensor is or comprises a silicon sensor chip. 5 . The composite venous catheter according to claim 2 , wherein the pressure sensor has an original sensing surface of the sensor, and the original sensing surface of the sensor is in a convex state under the action of the hydrogel. 6 . 6 . The composite venous catheter according to claim 5 , wherein a sensor packaged sensing surface is further provided outside the original sensing surface of the sensor, and the sensor packaged sensing surface is coated with medical Parylene series materials. 7 . , the thickness of the sensing surface of the sensor package is 1-10µm. 7. The composite venous catheter according to claim 1, wherein the at least one diaphragm is three diaphragms evenly distributed between the central lumen and the peripheral lumen, and the at least two diaphragms are The channels are 4 channels evenly distributed between the central lumen and the peripheral lumen. 8 . The composite venous catheter according to claim 1 , wherein the first channel has a plurality of outlets at the implantation end, and the first channel is any one of the at least two channels. 9 . 9. A control system for monitoring central venous pressure in real time, comprising the composite venous catheter according to any one of claims 1-8, an infusion pump and an interferometric pressure detector; wherein, the insertion end of the composite venous catheter Inserted into the infusion pump port, the line in the composite venous catheter for conducting the pressure sensor signal is connected to the interferometric pressure probe. 10 . The control system according to claim 9 , wherein the infusion pump is a peristaltic pump controlled by a private server. 11 .

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