CN101301202A - Wrist-type non-invasive photoacoustic blood glucose monitor - Google Patents

Abstract

The invention relates to a watch-type non-invasive photoacoustic blood glucose monitor, which is provided with a display screen, control buttons, a controller, a battery and a measurement box, an acoustic insulation layer, a sound-absorbing pad, a semiconductor laser tube, and a Fourier lens in the watch-type housing. , light-transmitting protective film and hollow multi-ring array sensor are integrated in the measurement box, forming an integrated coaxial confocal structure. The watch-like case is equipped with a strap worn on the wrist of the person being tested. The photoacoustic excitation source and the optical path lens system generate a focused laser beam, which passes through the hollow multi-ring array sensor and shoots to the blood vessels in the wrist to achieve continuous A-type dynamics. Focused scanning photoacoustic blood glucose detection provides photoacoustic blood glucose results at multiple points in the depth direction of the wrist. The invention has the advantages of compact structure, easy portability, easy operation, real-time monitoring of photoacoustic blood sugar, no trauma during detection, no need to extract blood and provide test paper, and avoid cross-infection and environmental influence.

Description

Wrist-type non-invasive photoacoustic blood glucose monitor

technical field

The invention relates to the technical fields of biomedical measurement and medical equipment, in particular to a watch-type non-invasive photoacoustic blood sugar monitor.

Background technique

At present, invasive or minimally invasive interventional methods are still commonly used for blood glucose testing, which require a small amount of peripheral blood and corresponding test strips, and the future development direction should be non-invasive non-invasive blood glucose testing techniques, such as photoacoustic analysis , spectral analysis, Raman spectroscopy, light scattering spectroscopy and optical polarization spectroscopy and other optical means. There are still many difficulties in the current photoacoustic analysis method. For example, due to the need for non-destructive detection, the energy of the incident laser cannot exceed the threshold value. Therefore, it is an urgent problem to be solved to effectively improve the photoacoustic excitation efficiency. In addition, photoacoustic detection mostly uses solid-state lasers as excitation sources, and there are certain difficulties in system integration and miniaturization.

In 2001, Z.Zhao and R.Myllyla, "Photoacoustic determination of glucose concentration in whole blood by a near-infrared laser diode" Proc.SPIE, 4256, 77-83, 2001. Reported photoacoustic blood glucose based on near-infrared laser diode excitation Concentration measurement method, but the detection method of the forward mode is difficult to apply clinically, and the confocal structure cannot be realized, the sensitivity of the system is very low, and the collected photoacoustic signals need to be averaged thousands of times. In 2003, A.A.Bednov, E.V.Savateeva, A.A.Oraevsky, "Glucose monitoring in wholeblood by measuring laser-induced acoustic profiles" Proc.SPIE, 4960, 21-29, 2003. Reported a photoacoustic blood glucose detection method based on the lateral detection mode, A high-power Nd:YAG laser is used as the excitation source, and the collected photoacoustic signals hardly need to be averaged, but large-volume solid-state lasers cannot achieve true miniaturization and practicability [Non-Patent Document 2]. Moreover, there is still a problem in the above methods. Since a single detector is used as the sensing part, the photoacoustic excitation and sensing cannot achieve a coaxial confocal structure. Therefore, the efficiency of photoacoustic excitation and detection is not high, and a large power is required. The solid-state laser provides photoacoustic excitation energy, or the average of thousands of signals is required to improve the signal-to-noise ratio, while the large-volume solid-state laser cannot realize the integration and miniaturization of excitation and sensing, and the signal average of multiple times is extremely large. The time resolution of the system is greatly reduced, and the forward and side detection modes lack the convenience of actual operation, and the actual promotion and application prospects are greatly limited.

Contents of the invention

The technical problem to be solved by the present invention is to provide a watch-type non-invasive photoacoustic blood glucose monitor with compact structure, easy to carry and easy to operate, which can simultaneously provide photoacoustic blood glucose monitoring results at multiple points in the depth direction of the wrist.

In order to solve the above technical problems, the technical solution of the present invention is: a watch-type non-invasive photoacoustic blood glucose monitor, which is characterized in that: a display screen and control buttons are arranged on the surface of the shell, and the bottom surface of the shell is a multi-layer adhesive board. The measurement box is placed on a multi-layer bonded board, and a hollow acoustic insulating layer and a sound-absorbing pad are arranged in the measuring box; a semiconductor laser tube is arranged on the top of the acoustic insulating layer, and a Fourier lens is arranged under the semiconductor laser tube , the bottom of the Fourier lens is provided with a light-transmitting protective film and a hollow multi-ring array sensor installed on a multi-layer bonding board; the centers of the semiconductor laser tube, Fourier lens, light-transmitting protective film and hollow multi-ring array sensor are all located in the same center On the axis, it is integrated and packaged in the measurement box to form an integrated coaxial confocal structure, which can effectively reduce the requirement of laser energy and improve the detection depth; the side of the measurement box is equipped with a controller and battery, and a hollow multi-ring array sensor Each ring of the controller is connected to the terminal of the controller through wires. The shell is in the form of a watch, and is equipped with a strap worn on the wrist of the detected person. The semiconductor laser tube is a semiconductor pulsed laser diode, working at one or more wavelengths in the range from ultraviolet to infrared. The semiconductor laser tube and Fourier lens form a photoacoustic excitation source and an optical path lens system to generate a focused laser beam, which passes through the light-transmitting protective film and the hollow inner ring of the hollow multi-ring array sensor, and shoots to the blood vessels in the wrist. The hollow multi-ring array sensor is a hollow planar array or a concave-convex array, which is made of piezoelectric materials, including lithium niobate, composite materials, piezoelectric ceramics or PVDF films; the hollow multi-ring array sensor adopts a back mode serial Or receive photoacoustic signals in parallel in real time to realize photoacoustic blood glucose detection of continuous A-type dynamic focus scanning, and provide photoacoustic blood glucose results at multiple points in the depth direction of the wrist.

The working process of the present invention is: under the trigger of the controller, the semiconductor laser tube is excited to generate pulsed laser, the wavelength, pulse width and repetition frequency can be selected according to the needs, the laser energy is collimated and focused through the optical path lens, and then radiated to the The blood vessels under the skin of the wrist, blood sugar and other functional groups absorb light energy and excite to generate photoacoustic signals; the controller simultaneously triggers the multi-ring array sensor to detect photoacoustic signals in the back mode to realize the excitation and sensing of photoacoustic signals; through certain algorithm processing The collected photoacoustic data can realize continuous A-type dynamic focus scanning detection of photoacoustic blood glucose in the depth direction, and obtain photoacoustic blood glucose results at multiple points in the depth direction of the wrist.

The beneficial effects of the present invention are:

1) The method of the present invention integrates the photoacoustic back receiving mode, excitation and sensing, and effectively realizes a miniaturized and practical watch-type system structure, which has the advantages of compact structure, easy portability, easy operation, and the ability to realize optical It has the advantages of real-time monitoring of blood glucose, non-invasive detection, no need to extract blood and provide test strips, and avoid cross-infection and environmental influence.

2) The present invention forms a photoacoustic excitation source, an optical path lens system and a multi-ring array sensor into a coaxial confocal structure, which can greatly improve the photoacoustic excitation and sensing efficiency, effectively reduce the laser energy requirements and improve the detection depth, and realize The continuous A-type dynamic focus scanning detection of photoacoustic blood glucose provides photoacoustic blood glucose results at multiple points in the depth direction of the wrist.

3) The present invention uses a cheap semiconductor laser tube to realize photoacoustic blood sugar monitoring, and the cost of each component is relatively low, so the cost of the overall device is also relatively low, which is easy to apply and popularize.

Description of drawings

Fig. 1 is a three-dimensional schematic diagram of the structure of the present invention.

Fig. 2 is a schematic diagram of the structure (A-A section of Fig. 1 ) of the present invention.

Figure 3 is a schematic diagram of the wiring of the multi-ring array sensor.

Fig. 4 is a schematic diagram of the present invention worn on the wrist.

Detailed ways

The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

Embodiment: a watch-type non-invasive photoacoustic blood glucose monitor, a display screen 11 and control buttons 18 are arranged on the surface of the watch-type housing 13, the bottom surface of the housing 13 is a multi-layer adhesive board 12, and the measurement box 7 is placed on a multi-layer Bonding board 12. A hollow acoustic insulating layer 6 and a sound-absorbing pad 5 are arranged in the measuring box 7 . On the top of the acoustic insulating layer 6, there is a semiconductor pulse laser diode 155G4S14X, Laser Components 1, the working wavelength is 1550nm, the peak power is 45W, the pulse width is 150ns, the single pulse energy is about 6.75uJ, and the duty cycle DF is 0.1%. A Fourier lens 2 is provided below the semiconductor pulsed laser diode 1, and a light-transmitting protective film 3 and a hollow multi-ring array sensor 4 installed on a multilayer adhesive plate 12 are arranged under the Fourier lens 2; the semiconductor laser tube 1, the Fourier The centers of the lens 2, the light-transmitting protective film 3 and the hollow multi-ring array sensor 4 are all located on the same central axis 15, and are integrally packaged in the measurement box 7 to form an integrated coaxial confocal structure. The hollow multi-ring array sensor 4 is a hollow planar array or concave-convex array, made of piezoelectric ceramics, the working center frequency is 2.5MHz, and the number of rings is 6. It is designed as a hollow planar ring array structure with equal area and equal spacing. The spacing is not greater than half a wavelength, and the speed of sound is set at 1500m/s. Each ring is connected to the terminal 20 of the controller 9 through wires 19 to realize the sensing and processing of photoacoustic signals. The light-transmitting protective film 3 has light-transmitting and waterproof functions, and can protect internal optical devices; the acoustic insulating layer 6 is used to prevent ultrasonic energy from being transmitted to the outer shell 13 and causing reflection interference signals. A controller 9 and a battery 10 are provided on the side of the measurement box 7 .

The watch-like casing 13 is equipped with a watch strap 17 worn on the wrist 8 of the person to be detected. The semiconductor pulse laser diode 1 and the Fourier lens 2 form a photoacoustic excitation source and an optical path lens system to generate a focused laser beam 14, which passes through the light-transmitting protective film 3 and the hollow inner ring of the hollow multi-ring array sensor 4 shoot to the blood vessel 16 in the wrist 8; the hollow multi-ring array sensor 4 adopts serial or parallel real-time reception of photoacoustic signals in back mode to realize continuous A-type dynamic focus scanning The advanced photoacoustic blood glucose detection provides photoacoustic blood glucose results at multiple points in the depth direction of the wrist.

Claims (5)

1. A watch type non-invasive photoacoustic blood glucose monitor is characterized in that: a display screen (11) and a control button (18) are arranged on the surface of the shell (13), and the bottom surface of the shell (13) is a multi-layer bonded plate (12), the measuring box (7) is placed on the multi-layer bonded board (12), and a hollow acoustic insulating layer (6) and a sound-absorbing pad (5) are provided in the measuring box (7); The top of the layer (6) is provided with a semiconductor laser tube (1), and a Fourier lens (2) is provided under the semiconductor laser tube (1), and a light-transmitting protective film (3) and an installation are provided under the Fourier lens (2). Hollow multi-ring array sensor (4) on the multi-layer bonding board (12); semiconductor laser tube (1), Fourier lens (2), light-transmitting protective film (3) and hollow multi-ring array sensor (4) The centers are all located on the same central axis (15), and are integrally packaged in the measurement box (7), forming an integrated coaxial confocal structure; a controller (9) and a battery ( 10), the rings of the hollow multi-ring array sensor (4) are respectively connected to the terminal (20) of the controller (9) through wires (19); the hollow multi-ring array sensor (4) adopts the back mode to receive photoacoustic The signal realizes photoacoustic blood glucose detection of continuous A-type dynamic focus scanning, and provides photoacoustic blood glucose results at multiple points in the depth direction of the wrist (8). 2. The watch-type non-invasive photoacoustic blood glucose monitor according to claim 1, characterized in that: the housing (13) is a watch-type, equipped with a watch strap (17) worn on the wrist (8) of the detected person ). 3. The watch-type non-invasive photoacoustic blood glucose monitor according to claim 1, characterized in that: the semiconductor laser tube (1) is a semiconductor pulsed laser diode, working at one or more wavelengths in the range from ultraviolet to infrared . 4. The watch-type non-invasive photoacoustic blood glucose monitor according to claim 1, characterized in that: the hollow multi-ring array sensor (4) is a hollow planar array or a concave-convex array. 5. The watch-type non-invasive photoacoustic blood glucose monitor according to claim 1, characterized in that: said semiconductor laser tube (1) and Fourier lens (2) form a photoacoustic excitation source and an optical path lens system to generate focused laser light The beam (14) passes through the light-transmitting protective film (3) and the hollow inner ring of the hollow multi-ring array sensor (4), and shoots to the blood vessel (16) in the wrist (8).

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