We encourage you to check out NCBI’s suite of assembly and annotation tools including the genome assembler SKESA, the taxonomic assignment tool ANI, and the prokaryotic genome annotation pipeline (PGAP).
The GO terms between NCBI HMMs and the corresponding Interpro entries were compared and evaluated over a substantial number of HMMs and updated (added: 307; deleted: 39; updated: 1,482).
Release 13.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the Prokaryotic Genome Annotation Pipeline (PGAP) is now available for download. You can search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package.
What’s new?
The 13.0 release contains:
16,143 HMMs maintained by NCBI
315 new HMMs since release 12.0
286 HMMs with better names, EC numbers, Gene Ontology (GO) terms, gene symbols or publications
This version has an improved user interface that takes the genome FASTA file and associated organism name directly on the command line. For example, to annotate a Vibrio cholerae genome sequence in the file Vchol.fasta:
Release 12.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the Prokaryotic Genome Annotation Pipeline (PGAP) is now available for download. You can search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package.
What’s new?
The 12.0 release contains:
15,849 HMMs maintained by NCBI
271 new HMMs since release 11.0
1,248 HMMs with better names, EC numbers, Gene Ontology (GO) terms, gene symbols or publications