BankIt Submitters: Upcoming Changes to How You Submit to GenBank

Are you a GenBank submitter? Do you use BankIt or the GenBank app in the NCBI Submission Portal to submit your sequences? Or do you split your data between the two systems?

Starting this spring, you will be able to complete all GenBank submissions in the portal! The Submission Portal GenBank will support data types that you currently submit through BankIt. You will no longer need to use BankIt, which will be phased out.

What is changing?

We are enhancing your submission experience by transitioning workflows from BankIt to the Submission Portal, creating a single-entry point for all your GenBank web submissions. Our modern and streamlined interface will offer: Continue reading “BankIt Submitters: Upcoming Changes to How You Submit to GenBank” →

GenBank Now Supports EGAPx-Based Annotation

With the latest release of EGAPx, we’re excited to announce that you can now submit genome assemblies with EGAPx annotations directly to GenBank. We’re making it easier for researchers to share richly annotated eukaryotic genomes, complete with structural and functional features generated by the EGAPx pipeline.

What’s new?

Easily integrate your EGAPx annotations into GenBank: You can now attach the EGAPx-generated ASN.1 annotation file as part of a submission package.

Continue reading “GenBank Now Supports EGAPx-Based Annotation” →

An Updated Bacterial and Archaeal Reference Genome Collection is Available!

Download the updated bacterial and archaeal reference genome collection! We built this collection of 22,420 genomes by selecting the “best” genome assembly for each species among the 450,000+ prokaryotic genomes in RefSeq.

What’s new?

One species is represented in this collection for the first time
323 species are represented by a better assembly
Six species were removed because of changes in NCBI Taxonomy or uncertainty in their species assignment

Continue reading “An Updated Bacterial and Archaeal Reference Genome Collection is Available!” →

Candidozyma and Cryptococcus Fungal Data now in the Multiple Comparative Genome Viewer (MCGV)!

NCBI’s Multiple Comparative Genome Viewer (MCGV) continues to expand available alignments! We are excited to announce the addition of two new fungal datasets: Candidozyma auris and Cryptococcus multigenome sequence alignments.

You can now visualize and compare multiple whole genome assemblies for these human pathogens, zooming in on specific genes, tracking evolutionary changes, and identifying critical nucleotide differences across a variety of fungal strains. Continue reading “Candidozyma and Cryptococcus Fungal Data now in the Multiple Comparative Genome Viewer (MCGV)!” →

Coming Soon: Updated PubMed Central (PMC) E-Utilities

PubMed Central (PMC) is moving to an updated version of the E-utilities API in early February 2026. This version of E-utilities will use the same technology as the updated PMC website search, which was released in September 2025. This change means search results returned by the updated ESearch E-utility will now match those of the PMC website.

Next steps

If you manage code that creates PMC E-utility requests, review the changes below to ensure that your code will continue to function after the update. This update only affects E-utility calls when the request specifies the PMC database, &db=pmc. There are no changes to the E-utilities for other databases. Continue reading “Coming Soon: Updated PubMed Central (PMC) E-Utilities” →

Top Posts of 2025: A Look at the NCBI Insights Blog

GenBank Release 269.0

GenBank release 269.0 (12/16/2025) is now available on the NCBI FTP site. This release has 49.73 trillion bases and 6.03 billion records.

The current release has:

259,677,058 traditional records containing 6,651,459,875,408 base pairs of sequence data
4,540,323,299 WGS records containing 42,125,323,988,215 base pairs of sequence data
1,033,885,396 bulk-oriented TSA records containing 878,730,431,459 base pairs of sequence data
190,904,203 bulk-oriented TLS records containing 78,916,795,339 base pairs of sequence data Continue reading “GenBank Release 269.0” →

Upcoming Change in My Bibliography

Use of earliest publication date for determining NIH Public Access compliance

As shared in the July National Center for Biotechnology Information (NCBI) Insights post, NCBI at the National Library of Medicine (NLM) is making ongoing improvements to several offerings to support implementation of the 2024 NIH Public Access Policy.

Effective October 1, 2025, My Bibliography will begin using the earliest publication date listed in PubMed records (whether print or electronic) in support of implementation of the 2024 NIH Public Access Policy update, which defines the Official Date of Publication as:

“The date on which the Final Published Article is first made available in final, edited form, whether in print or electronic (i.e., online) format.” Continue reading “Upcoming Change in My Bibliography” →

An Updated Bacterial and Archaeal Reference Genome Collection is Available!

Download the updated bacterial and archaeal reference genome collection! We built this collection of 22,082 genomes by selecting the “best” genome assembly for each species among the 440,000+ prokaryotic genomes in RefSeq.

What’s new?

28 species are represented in this collection for the first time
228 species are represented by a better assembly
Six species were removed because of changes in NCBI Taxonomy or uncertainty in their species assignment

Continue reading “An Updated Bacterial and Archaeal Reference Genome Collection is Available!” →

GenBank Release 268.0 is Available!

GenBank release 268.0 (8/18/2025) is now available on the NCBI FTP site. This release has 47.01 trillion bases and 5.90 billion records.

The current release has:

258,320,620 traditional records containing 5,676,067,778,413 base pairs of sequence data
4,441,331,387 WGS records containing 40,390,433,406,298 base pairs of sequence data
1,010,159,820 bulk-oriented TSA records containing 864,483,775,194 base pairs of sequence data
190,505,830 bulk-oriented TLS records containing 78,568,415,110 base pairs of sequence data

Continue reading “GenBank Release 268.0 is Available!” →