Let $u,a,b,n$ be nonnegative integers such that $n\le a+b$. Define the quantity $$ L(u,a,b,n):= (u+a+b-n)!\times\sum_{i,k,\ell}\ \frac{(-1)^k\ \ (u+a+b-i)!\ (k+\ell)!\ (a+b-k-\ell)!\ (u+a+b-k-\ell)!}{i!\ (n-i)!\ k!\ (a-k)!\ \ell!\ (b-\ell)!\ (a+b-k-\ell-i)!\ (k+\ell-n+i)!\ (u+a+b-k-\ell-i)!} $$ where the range of summation is $i,k,\ell\in\mathbb{Z}$ such that the arguments of all the factorials are nonnegative. Namely, this means the inequalities $$ 0\le i\le n\ ,\ 0\le k\le a\ , $$ and $$ \max(0,n-i-k)\le \ell\le\min(b,a+b-i-k)\ . $$
My question is: how to show that $L(u,a,b,n)$ is always nonnegative?
As per Timothy's comment, let me add some context.
Let $\mathbb{C}^{N}$ be equipped with the Hermitian inner product (with the physics convention of linearity on the right, and antilinearity on the left) $$ \langle v,w\rangle:=\sum_{i=1}^{N}\overline{v_i} w_i\ . $$ Let $v,w,\tilde{v},\tilde{w}$ be four independent uniform random vectors on the unit sphere of $\mathbb{C}^{N}$. Define the two independent random variables (or $U(N)$ invariant observables) $$ X:=|\langle v,w\rangle|^2\ ,\ Y:=|\langle \tilde{v},\tilde{w}\rangle|^2 $$ and consider the expectation $$ G(u,a,b):=\mathbb{E}\left[ X^u Y^u(X-Y)^a (X+Y)^b \right]\ . $$ With a bit of work, one can show that $$ G(u,a,b)=a! b!\ (N)_{u+a+b}^{-2}\sum_{n=0}^{a+b} L(u,a,b,n)\ (N-1)_{n} $$ where $(x)_n=x(x+1)\cdots(x+n-1)$ is the Pochhammer symbol.
If $a$ is odd then $G(u,a,b)=0$. If $a$ is even, then the integrand is nonnegative, and therefore we always have $G(u,a,b)\ge 0$. The case $u=0$, is the Ginibre inequality for the $\mathbb{C}\mathbb{P}^{N-1}$ model of statistical mechanics, with only two lattice sites. The consideration of the case $u>0$ was introduced in my paper "Non-Abelian correlation inequalities and stable determinantal polynomials".
If my conjecture on the positivity of the $L$'s is true, this would establish the positivity of $G$, even when $N\ge 1$ is not an integer, somewhat in the spirit of the work of Deligne on representations of the symmetric group of non-integer order, or the article "Deligne categories in lattice models and quantum field theory, or making sense of O(N) symmetry with non-integer N" by Binder and Rychkov.
Update: In the extreme case $n=a+b$, with $a$ even, I was able to prove $$ L(u,a,b,a+b)=u!^2 \binom{2u+a+b+1}{b} \binom{u+\frac{a}{2}}{\frac{a}{2}}\ . $$ This is in line with the predictions in the comments by Peter Taylor about the degree as a polynomial in $u$.