Papers by raghupathi ramtwnki
Pinnacle Blooms Network of Bharath Healthcare Laboratories Technical Monograph Series, 2026
Background: AbilityScore is a standardized composite developmental index (0-1000) that quantifies... more Background: AbilityScore is a standardized composite developmental index (0-1000) that quantifies child developmental performance relative to age-normed expectations. Operational data from more than 18.6 million therapy sessions show inter-rater reliability r = 0.91 and ICC = 0.88. However, formal concurrent validity against established reference instruments, controlled test-retest reliability, and minimal clinically important difference (MCID) have not been published. Objective: To determine the concurrent validity of AbilityScore against Vineland-3, CARS-2, Bayley-4, and ABAS-3; to assess the reliability of the 7-day test-retest; and to estimate a preliminary MCID. Methods: Cross-sectional multi-center psychometric validation study with a nested prospective testretest substudy. Component A: n = 300 children aged 7 months to 7 years assessed with AbilityScore and comparator instruments in the same session by blinded raters in 6 Pinnacle Blooms Network centers. Component B: n = 60 subset, reassessed at 7 days. Primary analysis: Pearson correlation (Bonferroniadjusted α = 0.017). Pre-registered SAP on OSF. Discussion: This study addresses the single most important evidence gap for AbilityScore. It will determine whether the instrument meets the accepted thresholds for concurrent validity (r ≥ 0.50) and reliability (ICC ≥ 0.80), allowing the progression from operational evidence to formal psychometric validation. Trial registration: CTRI (to be registered prior to first enrollment). OSF pre-registration of SAP (to be completed prior to data collection).
Pinnacle Blooms Network of Bharath Healthcare Laboratories Technical Monograph Series, 2026
Background: Since the late nineteenth century, developmental assessment has relied on a series of... more Background: Since the late nineteenth century, developmental assessment has relied on a series of siloed instruments rather than a single developmental score. A child assessed with ADOS-2, Vineland and Bayley receives three separate reports on three incompatible scales, leaving families and clinicians without a unified picture of progress. Objective: To describe the architecture, computation methodology, and preliminary psychometric evidence for AbilityScore, a standardized composite developmental index (0-1000) that quantifies observed functional developmental performance relative to agenormed expectations in multiple validated constructs. Methods: AbilityScore synthesizes the clinical essence of 25 internationally validated assessments into a single metric, mapping 339 skills across 148 abilities through structured clinical observations. The scoring algorithm uses a Skill Index (60%) and Ability Index (40%) weighted composite with age-gender normalization. Seven domain-specific Readiness Indexes (Speech, Motor, Behaviour, Cognitive, School, Self-Sufficiency, Mainstream) provide multidimensional profiling. Preliminary psychometric evidence comes from operational data from approximately 18.6 million therapy sessions spanning more than 70 centers, 4 Indian states, 16 languages, and 28 diagnostic categories. Results: Operational data show inter-rater reliability r = 0.91 (p < 0.001), intraclass correlation coefficient ICC = 0.88 (95% CI 0.84-0.91), mean absolute percentage error MAPE = 6.7%, and bias variance ratio ≤ 1.05. These real-world scoring consistency metrics from routine operations across more than 70 centers provide a robust operational foundation for the formal validation study now in planning, but do not substitute for controlled psychometric validation. Conclusions: AbilityScore is a scientifically struc-tured, WHO ICF-aligned composite index for developmental measurement. Formal concurrent validity testing against Vineland-3, CARS-2, and Bayley-4, along with test-retest reliability studies, are now in planning (BHCL-VAL-2026-001). This monograph documents the instrument in sufficient detail to support the upcoming validation studies, regulatory submissions, and clinical use.
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Papers by raghupathi ramtwnki